Affinity Data by PubMed id=8917645

PubMed code 8917645

Found 20 hits of Enzyme Inhibition Constant Data
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Thymidylate synthase (Mus musculus)	BDBM50022238 ((R)-5-Fluoro-1-((4S,5R)-4-hydroxy-5-methylphosphat...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	8	n/a	n/a	n/a	n/a	n/a	n/a
University of Minnesota Curated by ChEMBL					Assay Description Inhibition of cellular thymidylate synthase activity of mouse fibroblast (L929 TK-) in permeabilised cells.				J Med Chem 39: 4569-75 (1996) Article DOI: 10.1021/jm9603680 BindingDB Entry DOI: 10.7270/Q2445N57
University of Minnesota Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Thymidylate synthase (Mus musculus)	BDBM50022238 ((R)-5-Fluoro-1-((4S,5R)-4-hydroxy-5-methylphosphat...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	17	n/a	n/a	n/a	n/a	n/a	n/a
University of Minnesota Curated by ChEMBL					Assay Description Inhibition of cellular thymidylate synthase activity of murine leukemia cell line (L1210) in intact cells.				J Med Chem 39: 4569-75 (1996) Article DOI: 10.1021/jm9603680 BindingDB Entry DOI: 10.7270/Q2445N57
University of Minnesota Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Thymidylate synthase (Mus musculus)	BDBM50022238 ((R)-5-Fluoro-1-((4S,5R)-4-hydroxy-5-methylphosphat...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	42	n/a	n/a	n/a	n/a	n/a	n/a
University of Minnesota Curated by ChEMBL					Assay Description Inhibition of cellular thymidylate synthase activity of murine leukemia cell line (L1210) in permeabilised cells.				J Med Chem 39: 4569-75 (1996) Article DOI: 10.1021/jm9603680 BindingDB Entry DOI: 10.7270/Q2445N57
University of Minnesota Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Thymidylate synthase (Mus musculus)	BDBM50340678 (1-(beta-D-2-deoxy-erythro-pentofuranosyl)-5-fluoro...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	43	n/a	n/a	n/a	n/a	n/a	n/a
University of Minnesota Curated by ChEMBL					Assay Description Inhibition of cellular thymidylate synthase activity of murine leukemia cell line (L1210) in intact cells.				J Med Chem 39: 4569-75 (1996) Article DOI: 10.1021/jm9603680 BindingDB Entry DOI: 10.7270/Q2445N57
University of Minnesota Curated by ChEMBL					More data for this Ligand-Target Pair
Thymidylate synthase (Mus musculus)	BDBM50369176 (CHEMBL1791078) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	670	n/a	n/a	n/a	n/a	n/a	n/a
University of Minnesota Curated by ChEMBL					Assay Description Inhibition of cellular thymidylate synthase activity of mouse fibroblast (L929 TK-) in intact cells.				J Med Chem 39: 4569-75 (1996) Article DOI: 10.1021/jm9603680 BindingDB Entry DOI: 10.7270/Q2445N57
University of Minnesota Curated by ChEMBL					More data for this Ligand-Target Pair
Thymidylate synthase (Homo sapiens (Human))	BDBM50369176 (CHEMBL1791078) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	890	n/a	n/a	n/a	n/a	n/a	n/a
University of Minnesota Curated by ChEMBL					Assay Description Inhibition of cellular thymidylate synthase activity of mouse fibroblast (L929 TK-) in permeabilised cells.				J Med Chem 39: 4569-75 (1996) Article DOI: 10.1021/jm9603680 BindingDB Entry DOI: 10.7270/Q2445N57
University of Minnesota Curated by ChEMBL					More data for this Ligand-Target Pair
Thymidylate synthase (Mus musculus)	BDBM50054517 ((S)-2-{[5-(5-Fluoro-2,4-dioxo-3,4-dihydro-2H-pyrim...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Minnesota Curated by ChEMBL					Assay Description Inhibition of cellular thymidylate synthase activity of mouse fibroblast (L929 TK-) in intact cells.				J Med Chem 39: 4569-75 (1996) Article DOI: 10.1021/jm9603680 BindingDB Entry DOI: 10.7270/Q2445N57
University of Minnesota Curated by ChEMBL					More data for this Ligand-Target Pair
Thymidylate synthase (Mus musculus)	BDBM50369176 (CHEMBL1791078) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Minnesota Curated by ChEMBL					Assay Description Inhibition of cellular thymidylate synthase activity of murine leukemia cell line (L1210) in permeabilised cells.				J Med Chem 39: 4569-75 (1996) Article DOI: 10.1021/jm9603680 BindingDB Entry DOI: 10.7270/Q2445N57
University of Minnesota Curated by ChEMBL					More data for this Ligand-Target Pair
Thymidylate synthase (Mus musculus)	BDBM50054517 ((S)-2-{[5-(5-Fluoro-2,4-dioxo-3,4-dihydro-2H-pyrim...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Minnesota Curated by ChEMBL					Assay Description Inhibition of cellular thymidylate synthase activity of murine leukemia cell line (L1210) in permeabilised cells.				J Med Chem 39: 4569-75 (1996) Article DOI: 10.1021/jm9603680 BindingDB Entry DOI: 10.7270/Q2445N57
University of Minnesota Curated by ChEMBL					More data for this Ligand-Target Pair
Thymidylate synthase (Mus musculus)	BDBM50340678 (1-(beta-D-2-deoxy-erythro-pentofuranosyl)-5-fluoro...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	7.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Minnesota Curated by ChEMBL					Assay Description Inhibition of cellular thymidylate synthase activity of mouse fibroblast (L929 TK-) in intact cells.				J Med Chem 39: 4569-75 (1996) Article DOI: 10.1021/jm9603680 BindingDB Entry DOI: 10.7270/Q2445N57
University of Minnesota Curated by ChEMBL					More data for this Ligand-Target Pair
Thymidylate synthase (Mus musculus)	BDBM50022238 ((R)-5-Fluoro-1-((4S,5R)-4-hydroxy-5-methylphosphat...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Minnesota Curated by ChEMBL					Assay Description Inhibition of cellular thymidylate synthase activity of mouse fibroblast (L929 TK-) in intact cells.				J Med Chem 39: 4569-75 (1996) Article DOI: 10.1021/jm9603680 BindingDB Entry DOI: 10.7270/Q2445N57
University of Minnesota Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Thymidylate synthase (Mus musculus)	BDBM50340678 (1-(beta-D-2-deoxy-erythro-pentofuranosyl)-5-fluoro...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.10E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Minnesota Curated by ChEMBL					Assay Description Inhibition of cellular thymidylate synthase activity of mouse fibroblast (L929 TK-) in permeabilised cells.				J Med Chem 39: 4569-75 (1996) Article DOI: 10.1021/jm9603680 BindingDB Entry DOI: 10.7270/Q2445N57
University of Minnesota Curated by ChEMBL					More data for this Ligand-Target Pair
Thymidylate synthase (Mus musculus)	BDBM50369176 (CHEMBL1791078) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.20E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Minnesota Curated by ChEMBL					Assay Description Inhibition of cellular thymidylate synthase activity of murine leukemia cell line (L1210) in intact cells.				J Med Chem 39: 4569-75 (1996) Article DOI: 10.1021/jm9603680 BindingDB Entry DOI: 10.7270/Q2445N57
University of Minnesota Curated by ChEMBL					More data for this Ligand-Target Pair
Thymidylate synthase (Mus musculus)	BDBM50054517 ((S)-2-{[5-(5-Fluoro-2,4-dioxo-3,4-dihydro-2H-pyrim...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.10E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Minnesota Curated by ChEMBL					Assay Description Inhibition of cellular thymidylate synthase activity of murine leukemia cell line (L1210) in intact cells.				J Med Chem 39: 4569-75 (1996) Article DOI: 10.1021/jm9603680 BindingDB Entry DOI: 10.7270/Q2445N57
University of Minnesota Curated by ChEMBL					More data for this Ligand-Target Pair
Thymidylate synthase (Homo sapiens (Human))	BDBM50369176 (CHEMBL1791078) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.70E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Minnesota Curated by ChEMBL					Assay Description Inhibition of cellular thymidylate synthase activity of mouse fibroblast (L929 TK-) in intact cells.				J Med Chem 39: 4569-75 (1996) Article DOI: 10.1021/jm9603680 BindingDB Entry DOI: 10.7270/Q2445N57
University of Minnesota Curated by ChEMBL					More data for this Ligand-Target Pair
Thymidylate synthase (Mus musculus)	BDBM50340678 (1-(beta-D-2-deoxy-erythro-pentofuranosyl)-5-fluoro...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	5.90E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Minnesota Curated by ChEMBL					Assay Description Inhibition of cellular thymidylate synthase activity of murine leukemia cell line (L1210) in permeabilised cells.				J Med Chem 39: 4569-75 (1996) Article DOI: 10.1021/jm9603680 BindingDB Entry DOI: 10.7270/Q2445N57
University of Minnesota Curated by ChEMBL					More data for this Ligand-Target Pair
Thymidylate synthase (Homo sapiens (Human))	BDBM50054517 ((S)-2-{[5-(5-Fluoro-2,4-dioxo-3,4-dihydro-2H-pyrim...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.90E+5	n/a	n/a	n/a	n/a	n/a	n/a
University of Minnesota Curated by ChEMBL					Assay Description Inhibition of cellular thymidylate synthase activity of human leukemia cell line(CCRF-CEM) .				J Med Chem 39: 4569-75 (1996) Article DOI: 10.1021/jm9603680 BindingDB Entry DOI: 10.7270/Q2445N57
University of Minnesota Curated by ChEMBL					More data for this Ligand-Target Pair
Thymidylate synthase (Homo sapiens (Human))	BDBM50054517 ((S)-2-{[5-(5-Fluoro-2,4-dioxo-3,4-dihydro-2H-pyrim...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.90E+5	n/a	n/a	n/a	n/a	n/a	n/a
University of Minnesota Curated by ChEMBL					Assay Description Inhibition of cellular thymidylate synthase activity of human leukemia cell line(CCRF-CEM) .				J Med Chem 39: 4569-75 (1996) Article DOI: 10.1021/jm9603680 BindingDB Entry DOI: 10.7270/Q2445N57
University of Minnesota Curated by ChEMBL					More data for this Ligand-Target Pair
Thymidylate synthase (Mus musculus)	BDBM50054517 ((S)-2-{[5-(5-Fluoro-2,4-dioxo-3,4-dihydro-2H-pyrim...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+6	n/a	n/a	n/a	n/a	n/a	n/a
University of Minnesota Curated by ChEMBL					Assay Description Inhibition of cellular thymidylate synthase activity of mouse fibroblast (L929 TK-) in permeabilised cells				J Med Chem 39: 4569-75 (1996) Article DOI: 10.1021/jm9603680 BindingDB Entry DOI: 10.7270/Q2445N57
University of Minnesota Curated by ChEMBL					More data for this Ligand-Target Pair
Thymidylate synthase (Mus musculus)	BDBM50369176 (CHEMBL1791078) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+6	n/a	n/a	n/a	n/a	n/a	n/a
University of Minnesota Curated by ChEMBL					Assay Description Inhibition of cellular thymidylate synthase activity of mouse fibroblast (L929 TK-) in permeabilised cells				J Med Chem 39: 4569-75 (1996) Article DOI: 10.1021/jm9603680 BindingDB Entry DOI: 10.7270/Q2445N57
University of Minnesota Curated by ChEMBL					More data for this Ligand-Target Pair

* indicates data uncertainty>20%