Found 18 hits of Enzyme Inhibition Constant Data Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Retinoic acid receptor gamma
(Homo sapiens (Human)) | BDBM31883
(9-cis-retinoic acid (9cRA) | ALL-TRANS-RETINOIC AC...)Show SMILES C\C(\C=C\C1=C(C)CCCC1(C)C)=C/C=C/C(/C)=C/C(O)=O |c:4| Show InChI InChI=1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/b9-6+,12-11+,15-8+,16-14+ | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL MCE KEGG MMDB PC cid PC sid UniChem
Patents
Similars
| MMDB Article PubMed
| n/a | n/a | n/a | n/a | 20 | n/a | n/a | n/a | n/a |
Allergan Inc.
Curated by ChEMBL
| Assay Description Transcriptional activation in CV-1 cells expressing Retinoic acid receptor RAR gamma |
J Med Chem 39: 5027-30 (1997)
Article DOI: 10.1021/jm960687r BindingDB Entry DOI: 10.7270/Q2TT4Q2F |
More data for this Ligand-Target Pair | |
Retinoic acid receptor gamma
(Homo sapiens (Human)) | BDBM50055112
(4-[(5,5-Dimethyl-8-thiophen-2-yl-5,6-dihydro-napht...)Show SMILES CC1(C)CC=C(c2cccs2)c2cc(ccc12)C(=O)Nc1ccc(cc1)C(O)=O |t:4| Show InChI InChI=1S/C24H21NO3S/c1-24(2)12-11-18(21-4-3-13-29-21)19-14-16(7-10-20(19)24)22(26)25-17-8-5-15(6-9-17)23(27)28/h3-11,13-14H,12H2,1-2H3,(H,25,26)(H,27,28) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | n/a | >10 | n/a | n/a | n/a | n/a | n/a |
Allergan Inc.
Curated by ChEMBL
| Assay Description Inhibition of [3H]-ATRA binding to baculovirus expressed Retinoic acid receptor RAR gamma |
J Med Chem 39: 5027-30 (1997)
Article DOI: 10.1021/jm960687r BindingDB Entry DOI: 10.7270/Q2TT4Q2F |
More data for this Ligand-Target Pair | |
Retinoic acid receptor beta
(Homo sapiens (Human)) | BDBM50055112
(4-[(5,5-Dimethyl-8-thiophen-2-yl-5,6-dihydro-napht...)Show SMILES CC1(C)CC=C(c2cccs2)c2cc(ccc12)C(=O)Nc1ccc(cc1)C(O)=O |t:4| Show InChI InChI=1S/C24H21NO3S/c1-24(2)12-11-18(21-4-3-13-29-21)19-14-16(7-10-20(19)24)22(26)25-17-8-5-15(6-9-17)23(27)28/h3-11,13-14H,12H2,1-2H3,(H,25,26)(H,27,28) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | n/a | n/a | 115 | n/a | n/a | n/a | n/a |
Allergan Inc.
Curated by ChEMBL
| Assay Description Transcriptional activation in CV-1 cells expressing Retinoic acid receptor RAR beta |
J Med Chem 39: 5027-30 (1997)
Article DOI: 10.1021/jm960687r BindingDB Entry DOI: 10.7270/Q2TT4Q2F |
More data for this Ligand-Target Pair | |
Retinoic acid receptor beta
(Homo sapiens (Human)) | BDBM31883
(9-cis-retinoic acid (9cRA) | ALL-TRANS-RETINOIC AC...)Show SMILES C\C(\C=C\C1=C(C)CCCC1(C)C)=C/C=C/C(/C)=C/C(O)=O |c:4| Show InChI InChI=1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/b9-6+,12-11+,15-8+,16-14+ | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL MCE KEGG MMDB PC cid PC sid UniChem
Patents
Similars
| MMDB Article PubMed
| n/a | n/a | n/a | 13 | n/a | n/a | n/a | n/a | n/a |
Allergan Inc.
Curated by ChEMBL
| Assay Description Inhibition of [3H]-ATRA binding to baculovirus expressed Retinoic acid receptor RAR beta |
J Med Chem 39: 5027-30 (1997)
Article DOI: 10.1021/jm960687r BindingDB Entry DOI: 10.7270/Q2TT4Q2F |
More data for this Ligand-Target Pair | |
Retinoic acid receptor alpha
(Homo sapiens (Human)) | BDBM50055114
(4-(5,5-Dimethyl-8-thiophen-2-yl-5,6-dihydro-naphth...)Show SMILES CC1(C)CC=C(c2cccs2)c2cc(ccc12)C#Cc1ccc(cc1)C(O)=O |t:4| Show InChI InChI=1S/C25H20O2S/c1-25(2)14-13-20(23-4-3-15-28-23)21-16-18(9-12-22(21)25)6-5-17-7-10-19(11-8-17)24(26)27/h3-4,7-13,15-16H,14H2,1-2H3,(H,26,27) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
| Article PubMed
| n/a | n/a | n/a | 129 | n/a | n/a | n/a | n/a | n/a |
Allergan Inc.
Curated by ChEMBL
| Assay Description Inhibition of [3H]-ATRA binding to baculovirus expressed Retinoic acid receptor RAR alpha |
J Med Chem 39: 5027-30 (1997)
Article DOI: 10.1021/jm960687r BindingDB Entry DOI: 10.7270/Q2TT4Q2F |
More data for this Ligand-Target Pair | |
Retinoic acid receptor beta
(Homo sapiens (Human)) | BDBM50055113
(5,5-Dimethyl-8-thiophen-2-yl-5,6-dihydro-naphthale...)Show SMILES CC1(C)CC=C(c2cccs2)c2cc(ccc12)C(=O)Oc1ccc(cc1)C(O)=O |t:4| Show InChI InChI=1S/C24H20O4S/c1-24(2)12-11-18(21-4-3-13-29-21)19-14-16(7-10-20(19)24)23(27)28-17-8-5-15(6-9-17)22(25)26/h3-11,13-14H,12H2,1-2H3,(H,25,26) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
| Article PubMed
| n/a | n/a | n/a | n/a | 26 | n/a | n/a | n/a | n/a |
Allergan Inc.
Curated by ChEMBL
| Assay Description Transcriptional activation in CV-1 cells expressing Retinoic acid receptor RAR beta |
J Med Chem 39: 5027-30 (1997)
Article DOI: 10.1021/jm960687r BindingDB Entry DOI: 10.7270/Q2TT4Q2F |
More data for this Ligand-Target Pair | |
Retinoic acid receptor beta
(Homo sapiens (Human)) | BDBM50055113
(5,5-Dimethyl-8-thiophen-2-yl-5,6-dihydro-naphthale...)Show SMILES CC1(C)CC=C(c2cccs2)c2cc(ccc12)C(=O)Oc1ccc(cc1)C(O)=O |t:4| Show InChI InChI=1S/C24H20O4S/c1-24(2)12-11-18(21-4-3-13-29-21)19-14-16(7-10-20(19)24)23(27)28-17-8-5-15(6-9-17)22(25)26/h3-11,13-14H,12H2,1-2H3,(H,25,26) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
| Article PubMed
| n/a | n/a | n/a | 189 | n/a | n/a | n/a | n/a | n/a |
Allergan Inc.
Curated by ChEMBL
| Assay Description Inhibition of [3H]-ATRA binding to baculovirus expressed Retinoic acid receptor RAR beta |
J Med Chem 39: 5027-30 (1997)
Article DOI: 10.1021/jm960687r BindingDB Entry DOI: 10.7270/Q2TT4Q2F |
More data for this Ligand-Target Pair | |
Retinoic acid receptor beta
(Homo sapiens (Human)) | BDBM50055114
(4-(5,5-Dimethyl-8-thiophen-2-yl-5,6-dihydro-naphth...)Show SMILES CC1(C)CC=C(c2cccs2)c2cc(ccc12)C#Cc1ccc(cc1)C(O)=O |t:4| Show InChI InChI=1S/C25H20O2S/c1-25(2)14-13-20(23-4-3-15-28-23)21-16-18(9-12-22(21)25)6-5-17-7-10-19(11-8-17)24(26)27/h3-4,7-13,15-16H,14H2,1-2H3,(H,26,27) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
| Article PubMed
| n/a | n/a | n/a | 20 | n/a | n/a | n/a | n/a | n/a |
Allergan Inc.
Curated by ChEMBL
| Assay Description Inhibition of [3H]-ATRA binding to baculovirus expressed Retinoic acid receptor RAR beta |
J Med Chem 39: 5027-30 (1997)
Article DOI: 10.1021/jm960687r BindingDB Entry DOI: 10.7270/Q2TT4Q2F |
More data for this Ligand-Target Pair | |
Retinoic acid receptor beta
(Homo sapiens (Human)) | BDBM31883
(9-cis-retinoic acid (9cRA) | ALL-TRANS-RETINOIC AC...)Show SMILES C\C(\C=C\C1=C(C)CCCC1(C)C)=C/C=C/C(/C)=C/C(O)=O |c:4| Show InChI InChI=1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/b9-6+,12-11+,15-8+,16-14+ | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL MCE KEGG MMDB PC cid PC sid UniChem
Patents
Similars
| MMDB Article PubMed
| n/a | n/a | n/a | n/a | 87 | n/a | n/a | n/a | n/a |
Allergan Inc.
Curated by ChEMBL
| Assay Description Transcriptional activation in CV-1 cells expressing Retinoic acid receptor RAR beta |
J Med Chem 39: 5027-30 (1997)
Article DOI: 10.1021/jm960687r BindingDB Entry DOI: 10.7270/Q2TT4Q2F |
More data for this Ligand-Target Pair | |
Retinoic acid receptor beta
(Homo sapiens (Human)) | BDBM50055112
(4-[(5,5-Dimethyl-8-thiophen-2-yl-5,6-dihydro-napht...)Show SMILES CC1(C)CC=C(c2cccs2)c2cc(ccc12)C(=O)Nc1ccc(cc1)C(O)=O |t:4| Show InChI InChI=1S/C24H21NO3S/c1-24(2)12-11-18(21-4-3-13-29-21)19-14-16(7-10-20(19)24)22(26)25-17-8-5-15(6-9-17)23(27)28/h3-11,13-14H,12H2,1-2H3,(H,25,26)(H,27,28) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | n/a | 996 | n/a | n/a | n/a | n/a | n/a |
Allergan Inc.
Curated by ChEMBL
| Assay Description Inhibition of [3H]-ATRA binding to baculovirus expressed Retinoic acid receptor RAR beta |
J Med Chem 39: 5027-30 (1997)
Article DOI: 10.1021/jm960687r BindingDB Entry DOI: 10.7270/Q2TT4Q2F |
More data for this Ligand-Target Pair | |
Retinoic acid receptor alpha
(Homo sapiens (Human)) | BDBM31883
(9-cis-retinoic acid (9cRA) | ALL-TRANS-RETINOIC AC...)Show SMILES C\C(\C=C\C1=C(C)CCCC1(C)C)=C/C=C/C(/C)=C/C(O)=O |c:4| Show InChI InChI=1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/b9-6+,12-11+,15-8+,16-14+ | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL MCE KEGG MMDB PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | n/a | n/a | 459 | n/a | n/a | n/a | n/a |
Allergan Inc.
Curated by ChEMBL
| Assay Description Transcriptional activation in CV-1 cells expressing Retinoic acid receptor RAR alpha |
J Med Chem 39: 5027-30 (1997)
Article DOI: 10.1021/jm960687r BindingDB Entry DOI: 10.7270/Q2TT4Q2F |
More data for this Ligand-Target Pair | |
Retinoic acid receptor gamma
(Homo sapiens (Human)) | BDBM50055113
(5,5-Dimethyl-8-thiophen-2-yl-5,6-dihydro-naphthale...)Show SMILES CC1(C)CC=C(c2cccs2)c2cc(ccc12)C(=O)Oc1ccc(cc1)C(O)=O |t:4| Show InChI InChI=1S/C24H20O4S/c1-24(2)12-11-18(21-4-3-13-29-21)19-14-16(7-10-20(19)24)23(27)28-17-8-5-15(6-9-17)22(25)26/h3-11,13-14H,12H2,1-2H3,(H,25,26) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
| Article PubMed
| n/a | n/a | n/a | 1.49E+3 | n/a | n/a | n/a | n/a | n/a |
Allergan Inc.
Curated by ChEMBL
| Assay Description Inhibition of [3H]-ATRA binding to baculovirus expressed Retinoic acid receptor RAR gamma |
J Med Chem 39: 5027-30 (1997)
Article DOI: 10.1021/jm960687r BindingDB Entry DOI: 10.7270/Q2TT4Q2F |
More data for this Ligand-Target Pair | |
Retinoic acid receptor gamma
(Homo sapiens (Human)) | BDBM31883
(9-cis-retinoic acid (9cRA) | ALL-TRANS-RETINOIC AC...)Show SMILES C\C(\C=C\C1=C(C)CCCC1(C)C)=C/C=C/C(/C)=C/C(O)=O |c:4| Show InChI InChI=1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/b9-6+,12-11+,15-8+,16-14+ | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL MCE KEGG MMDB PC cid PC sid UniChem
Patents
Similars
| MMDB Article PubMed
| n/a | n/a | n/a | 18 | n/a | n/a | n/a | n/a | n/a |
Allergan Inc.
Curated by ChEMBL
| Assay Description Inhibition of [3H]-ATRA binding to baculovirus expressed Retinoic acid receptor RAR gamma |
J Med Chem 39: 5027-30 (1997)
Article DOI: 10.1021/jm960687r BindingDB Entry DOI: 10.7270/Q2TT4Q2F |
More data for this Ligand-Target Pair | |
Retinoic acid receptor alpha
(Homo sapiens (Human)) | BDBM50055113
(5,5-Dimethyl-8-thiophen-2-yl-5,6-dihydro-naphthale...)Show SMILES CC1(C)CC=C(c2cccs2)c2cc(ccc12)C(=O)Oc1ccc(cc1)C(O)=O |t:4| Show InChI InChI=1S/C24H20O4S/c1-24(2)12-11-18(21-4-3-13-29-21)19-14-16(7-10-20(19)24)23(27)28-17-8-5-15(6-9-17)22(25)26/h3-11,13-14H,12H2,1-2H3,(H,25,26) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
| Article PubMed
| n/a | n/a | n/a | 303 | n/a | n/a | n/a | n/a | n/a |
Allergan Inc.
Curated by ChEMBL
| Assay Description Inhibition of [3H]-ATRA binding to baculovirus expressed Retinoic acid receptor RAR alpha |
J Med Chem 39: 5027-30 (1997)
Article DOI: 10.1021/jm960687r BindingDB Entry DOI: 10.7270/Q2TT4Q2F |
More data for this Ligand-Target Pair | |
Retinoic acid receptor alpha
(Homo sapiens (Human)) | BDBM50055112
(4-[(5,5-Dimethyl-8-thiophen-2-yl-5,6-dihydro-napht...)Show SMILES CC1(C)CC=C(c2cccs2)c2cc(ccc12)C(=O)Nc1ccc(cc1)C(O)=O |t:4| Show InChI InChI=1S/C24H21NO3S/c1-24(2)12-11-18(21-4-3-13-29-21)19-14-16(7-10-20(19)24)22(26)25-17-8-5-15(6-9-17)23(27)28/h3-11,13-14H,12H2,1-2H3,(H,25,26)(H,27,28) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | n/a | 94 | n/a | n/a | n/a | n/a | n/a |
Allergan Inc.
Curated by ChEMBL
| Assay Description Inhibition of [3H]-ATRA binding to baculovirus expressed Retinoic acid receptor RAR alpha |
J Med Chem 39: 5027-30 (1997)
Article DOI: 10.1021/jm960687r BindingDB Entry DOI: 10.7270/Q2TT4Q2F |
More data for this Ligand-Target Pair | |
Retinoic acid receptor gamma
(Homo sapiens (Human)) | BDBM50055114
(4-(5,5-Dimethyl-8-thiophen-2-yl-5,6-dihydro-naphth...)Show SMILES CC1(C)CC=C(c2cccs2)c2cc(ccc12)C#Cc1ccc(cc1)C(O)=O |t:4| Show InChI InChI=1S/C25H20O2S/c1-25(2)14-13-20(23-4-3-15-28-23)21-16-18(9-12-22(21)25)6-5-17-7-10-19(11-8-17)24(26)27/h3-4,7-13,15-16H,14H2,1-2H3,(H,26,27) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
| Article PubMed
| n/a | n/a | n/a | 104 | n/a | n/a | n/a | n/a | n/a |
Allergan Inc.
Curated by ChEMBL
| Assay Description Inhibition of [3H]-ATRA binding to baculovirus expressed Retinoic acid receptor RAR gamma |
J Med Chem 39: 5027-30 (1997)
Article DOI: 10.1021/jm960687r BindingDB Entry DOI: 10.7270/Q2TT4Q2F |
More data for this Ligand-Target Pair | |
Retinoic acid receptor beta
(Homo sapiens (Human)) | BDBM50055114
(4-(5,5-Dimethyl-8-thiophen-2-yl-5,6-dihydro-naphth...)Show SMILES CC1(C)CC=C(c2cccs2)c2cc(ccc12)C#Cc1ccc(cc1)C(O)=O |t:4| Show InChI InChI=1S/C25H20O2S/c1-25(2)14-13-20(23-4-3-15-28-23)21-16-18(9-12-22(21)25)6-5-17-7-10-19(11-8-17)24(26)27/h3-4,7-13,15-16H,14H2,1-2H3,(H,26,27) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
| Article PubMed
| n/a | n/a | n/a | n/a | 25 | n/a | n/a | n/a | n/a |
Allergan Inc.
Curated by ChEMBL
| Assay Description Transcriptional activation in CV-1 cells expressing Retinoic acid receptor RAR beta |
J Med Chem 39: 5027-30 (1997)
Article DOI: 10.1021/jm960687r BindingDB Entry DOI: 10.7270/Q2TT4Q2F |
More data for this Ligand-Target Pair | |
Retinoic acid receptor alpha
(Homo sapiens (Human)) | BDBM31883
(9-cis-retinoic acid (9cRA) | ALL-TRANS-RETINOIC AC...)Show SMILES C\C(\C=C\C1=C(C)CCCC1(C)C)=C/C=C/C(/C)=C/C(O)=O |c:4| Show InChI InChI=1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/b9-6+,12-11+,15-8+,16-14+ | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL MCE KEGG MMDB PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | n/a | 15 | n/a | n/a | n/a | n/a | n/a |
Allergan Inc.
Curated by ChEMBL
| Assay Description Inhibition of [3H]-ATRA binding to baculovirus expressed Retinoic acid receptor RAR alpha |
J Med Chem 39: 5027-30 (1997)
Article DOI: 10.1021/jm960687r BindingDB Entry DOI: 10.7270/Q2TT4Q2F |
More data for this Ligand-Target Pair | |