Found 17 hits of Enzyme Inhibition Constant Data Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
5-hydroxytryptamine receptor 1F
(Homo sapiens (Human)) | BDBM85195
(CAS_5311097 | LY 344864 | NSC_5311097)Show SMILES CN(C)C1CCc2[nH]c3ccc(NC(=O)c4ccc(F)cc4)cc3c2C1 Show InChI InChI=1S/C21H22FN3O/c1-25(2)16-8-10-20-18(12-16)17-11-15(7-9-19(17)24-20)23-21(26)13-3-5-14(22)6-4-13/h3-7,9,11,16,24H,8,10,12H2,1-2H3,(H,23,26) | PDB
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| 6 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Eli Lilly and Co.
Curated by PDSP Ki Database
| |
Life Sci 61: 2117-26 (1997)
Article DOI: 10.1016/s0024-3205(97)00885-0
BindingDB Entry DOI: 10.7270/Q2F47MNN |
More data for this
Ligand-Target Pair | |
5-hydroxytryptamine receptor 1B
(Homo sapiens (Human)) | BDBM85195
(CAS_5311097 | LY 344864 | NSC_5311097)Show SMILES CN(C)C1CCc2[nH]c3ccc(NC(=O)c4ccc(F)cc4)cc3c2C1 Show InChI InChI=1S/C21H22FN3O/c1-25(2)16-8-10-20-18(12-16)17-11-15(7-9-19(17)24-20)23-21(26)13-3-5-14(22)6-4-13/h3-7,9,11,16,24H,8,10,12H2,1-2H3,(H,23,26) | PDB
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PubMed
| 549 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Eli Lilly and Co.
Curated by PDSP Ki Database
| |
Life Sci 61: 2117-26 (1997)
Article DOI: 10.1016/s0024-3205(97)00885-0
BindingDB Entry DOI: 10.7270/Q2F47MNN |
More data for this
Ligand-Target Pair | |
5-hydroxytryptamine receptor 1D
(Homo sapiens (Human)) | BDBM85195
(CAS_5311097 | LY 344864 | NSC_5311097)Show SMILES CN(C)C1CCc2[nH]c3ccc(NC(=O)c4ccc(F)cc4)cc3c2C1 Show InChI InChI=1S/C21H22FN3O/c1-25(2)16-8-10-20-18(12-16)17-11-15(7-9-19(17)24-20)23-21(26)13-3-5-14(22)6-4-13/h3-7,9,11,16,24H,8,10,12H2,1-2H3,(H,23,26) | PDB
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| 575 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Eli Lilly and Co.
Curated by PDSP Ki Database
| |
Life Sci 61: 2117-26 (1997)
Article DOI: 10.1016/s0024-3205(97)00885-0
BindingDB Entry DOI: 10.7270/Q2F47MNN |
More data for this
Ligand-Target Pair | |
5-hydroxytryptamine receptor 1E
(Homo sapiens (Human)) | BDBM85195
(CAS_5311097 | LY 344864 | NSC_5311097)Show SMILES CN(C)C1CCc2[nH]c3ccc(NC(=O)c4ccc(F)cc4)cc3c2C1 Show InChI InChI=1S/C21H22FN3O/c1-25(2)16-8-10-20-18(12-16)17-11-15(7-9-19(17)24-20)23-21(26)13-3-5-14(22)6-4-13/h3-7,9,11,16,24H,8,10,12H2,1-2H3,(H,23,26) | PDB
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| 1.42E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Eli Lilly and Co.
Curated by PDSP Ki Database
| |
Life Sci 61: 2117-26 (1997)
Article DOI: 10.1016/s0024-3205(97)00885-0
BindingDB Entry DOI: 10.7270/Q2F47MNN |
More data for this
Ligand-Target Pair | |
5-hydroxytryptamine receptor 2B
(Homo sapiens (Human)) | BDBM85195
(CAS_5311097 | LY 344864 | NSC_5311097)Show SMILES CN(C)C1CCc2[nH]c3ccc(NC(=O)c4ccc(F)cc4)cc3c2C1 Show InChI InChI=1S/C21H22FN3O/c1-25(2)16-8-10-20-18(12-16)17-11-15(7-9-19(17)24-20)23-21(26)13-3-5-14(22)6-4-13/h3-7,9,11,16,24H,8,10,12H2,1-2H3,(H,23,26) | PDB
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| 1.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Eli Lilly and Co.
Curated by PDSP Ki Database
| |
Life Sci 61: 2117-26 (1997)
Article DOI: 10.1016/s0024-3205(97)00885-0
BindingDB Entry DOI: 10.7270/Q2F47MNN |
More data for this
Ligand-Target Pair | |
5-hydroxytryptamine receptor 2C
(Homo sapiens (Human)) | BDBM85195
(CAS_5311097 | LY 344864 | NSC_5311097)Show SMILES CN(C)C1CCc2[nH]c3ccc(NC(=O)c4ccc(F)cc4)cc3c2C1 Show InChI InChI=1S/C21H22FN3O/c1-25(2)16-8-10-20-18(12-16)17-11-15(7-9-19(17)24-20)23-21(26)13-3-5-14(22)6-4-13/h3-7,9,11,16,24H,8,10,12H2,1-2H3,(H,23,26) | PDB
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| 3.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Eli Lilly and Co.
Curated by PDSP Ki Database
| |
Life Sci 61: 2117-26 (1997)
Article DOI: 10.1016/s0024-3205(97)00885-0
BindingDB Entry DOI: 10.7270/Q2F47MNN |
More data for this
Ligand-Target Pair | |
Alpha-2C adrenergic receptor
(RAT) | BDBM85195
(CAS_5311097 | LY 344864 | NSC_5311097)Show SMILES CN(C)C1CCc2[nH]c3ccc(NC(=O)c4ccc(F)cc4)cc3c2C1 Show InChI InChI=1S/C21H22FN3O/c1-25(2)16-8-10-20-18(12-16)17-11-15(7-9-19(17)24-20)23-21(26)13-3-5-14(22)6-4-13/h3-7,9,11,16,24H,8,10,12H2,1-2H3,(H,23,26) | PDB
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| 3.69E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Eli Lilly and Co.
Curated by PDSP Ki Database
| |
Life Sci 61: 2117-26 (1997)
Article DOI: 10.1016/s0024-3205(97)00885-0
BindingDB Entry DOI: 10.7270/Q2F47MNN |
More data for this
Ligand-Target Pair | |
5-hydroxytryptamine receptor 2A
(Homo sapiens (Human)) | BDBM85195
(CAS_5311097 | LY 344864 | NSC_5311097)Show SMILES CN(C)C1CCc2[nH]c3ccc(NC(=O)c4ccc(F)cc4)cc3c2C1 Show InChI InChI=1S/C21H22FN3O/c1-25(2)16-8-10-20-18(12-16)17-11-15(7-9-19(17)24-20)23-21(26)13-3-5-14(22)6-4-13/h3-7,9,11,16,24H,8,10,12H2,1-2H3,(H,23,26) | PDB
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| 3.94E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Eli Lilly and Co.
Curated by PDSP Ki Database
| |
Life Sci 61: 2117-26 (1997)
Article DOI: 10.1016/s0024-3205(97)00885-0
BindingDB Entry DOI: 10.7270/Q2F47MNN |
More data for this
Ligand-Target Pair | |
5-hydroxytryptamine receptor 7
(Homo sapiens (Human)) | BDBM85195
(CAS_5311097 | LY 344864 | NSC_5311097)Show SMILES CN(C)C1CCc2[nH]c3ccc(NC(=O)c4ccc(F)cc4)cc3c2C1 Show InChI InChI=1S/C21H22FN3O/c1-25(2)16-8-10-20-18(12-16)17-11-15(7-9-19(17)24-20)23-21(26)13-3-5-14(22)6-4-13/h3-7,9,11,16,24H,8,10,12H2,1-2H3,(H,23,26) | PDB
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| 4.85E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Eli Lilly and Co.
Curated by PDSP Ki Database
| |
Life Sci 61: 2117-26 (1997)
Article DOI: 10.1016/s0024-3205(97)00885-0
BindingDB Entry DOI: 10.7270/Q2F47MNN |
More data for this
Ligand-Target Pair | |
Alpha-1A adrenergic receptor
(Rattus norvegicus (Rat)) | BDBM85195
(CAS_5311097 | LY 344864 | NSC_5311097)Show SMILES CN(C)C1CCc2[nH]c3ccc(NC(=O)c4ccc(F)cc4)cc3c2C1 Show InChI InChI=1S/C21H22FN3O/c1-25(2)16-8-10-20-18(12-16)17-11-15(7-9-19(17)24-20)23-21(26)13-3-5-14(22)6-4-13/h3-7,9,11,16,24H,8,10,12H2,1-2H3,(H,23,26) | PDB
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| 5.06E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Eli Lilly and Co.
Curated by PDSP Ki Database
| |
Life Sci 61: 2117-26 (1997)
Article DOI: 10.1016/s0024-3205(97)00885-0
BindingDB Entry DOI: 10.7270/Q2F47MNN |
More data for this
Ligand-Target Pair | |
Gamma-aminobutyric acid receptor subunit alpha-1
(Rattus norvegicus (Rat)) | BDBM85195
(CAS_5311097 | LY 344864 | NSC_5311097)Show SMILES CN(C)C1CCc2[nH]c3ccc(NC(=O)c4ccc(F)cc4)cc3c2C1 Show InChI InChI=1S/C21H22FN3O/c1-25(2)16-8-10-20-18(12-16)17-11-15(7-9-19(17)24-20)23-21(26)13-3-5-14(22)6-4-13/h3-7,9,11,16,24H,8,10,12H2,1-2H3,(H,23,26) | PDB
UniProtKB/SwissProt
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| >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Eli Lilly and Co.
Curated by PDSP Ki Database
| |
Life Sci 61: 2117-26 (1997)
Article DOI: 10.1016/s0024-3205(97)00885-0
BindingDB Entry DOI: 10.7270/Q2F47MNN |
More data for this
Ligand-Target Pair | |
Histamine H1 receptor
(RAT) | BDBM85195
(CAS_5311097 | LY 344864 | NSC_5311097)Show SMILES CN(C)C1CCc2[nH]c3ccc(NC(=O)c4ccc(F)cc4)cc3c2C1 Show InChI InChI=1S/C21H22FN3O/c1-25(2)16-8-10-20-18(12-16)17-11-15(7-9-19(17)24-20)23-21(26)13-3-5-14(22)6-4-13/h3-7,9,11,16,24H,8,10,12H2,1-2H3,(H,23,26) | KEGG
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| >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Eli Lilly and Co.
Curated by PDSP Ki Database
| |
Life Sci 61: 2117-26 (1997)
Article DOI: 10.1016/s0024-3205(97)00885-0
BindingDB Entry DOI: 10.7270/Q2F47MNN |
More data for this
Ligand-Target Pair | |
D(1A) dopamine receptor
(RAT) | BDBM85195
(CAS_5311097 | LY 344864 | NSC_5311097)Show SMILES CN(C)C1CCc2[nH]c3ccc(NC(=O)c4ccc(F)cc4)cc3c2C1 Show InChI InChI=1S/C21H22FN3O/c1-25(2)16-8-10-20-18(12-16)17-11-15(7-9-19(17)24-20)23-21(26)13-3-5-14(22)6-4-13/h3-7,9,11,16,24H,8,10,12H2,1-2H3,(H,23,26) | PDB
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| >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Eli Lilly and Co.
Curated by PDSP Ki Database
| |
Life Sci 61: 2117-26 (1997)
Article DOI: 10.1016/s0024-3205(97)00885-0
BindingDB Entry DOI: 10.7270/Q2F47MNN |
More data for this
Ligand-Target Pair | |
Muscarinic acetylcholine receptor M2
(RAT) | BDBM85195
(CAS_5311097 | LY 344864 | NSC_5311097)Show SMILES CN(C)C1CCc2[nH]c3ccc(NC(=O)c4ccc(F)cc4)cc3c2C1 Show InChI InChI=1S/C21H22FN3O/c1-25(2)16-8-10-20-18(12-16)17-11-15(7-9-19(17)24-20)23-21(26)13-3-5-14(22)6-4-13/h3-7,9,11,16,24H,8,10,12H2,1-2H3,(H,23,26) | PDB
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| >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Eli Lilly and Co.
Curated by PDSP Ki Database
| |
Life Sci 61: 2117-26 (1997)
Article DOI: 10.1016/s0024-3205(97)00885-0
BindingDB Entry DOI: 10.7270/Q2F47MNN |
More data for this
Ligand-Target Pair | |
Beta-2 adrenergic receptor
(Rattus norvegicus) | BDBM85195
(CAS_5311097 | LY 344864 | NSC_5311097)Show SMILES CN(C)C1CCc2[nH]c3ccc(NC(=O)c4ccc(F)cc4)cc3c2C1 Show InChI InChI=1S/C21H22FN3O/c1-25(2)16-8-10-20-18(12-16)17-11-15(7-9-19(17)24-20)23-21(26)13-3-5-14(22)6-4-13/h3-7,9,11,16,24H,8,10,12H2,1-2H3,(H,23,26) | PDB
MMDB
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| >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Eli Lilly and Co.
Curated by PDSP Ki Database
| |
Life Sci 61: 2117-26 (1997)
Article DOI: 10.1016/s0024-3205(97)00885-0
BindingDB Entry DOI: 10.7270/Q2F47MNN |
More data for this
Ligand-Target Pair | |
Gamma-aminobutyric acid receptor subunit alpha-1
(Rattus norvegicus (Rat)) | BDBM85195
(CAS_5311097 | LY 344864 | NSC_5311097)Show SMILES CN(C)C1CCc2[nH]c3ccc(NC(=O)c4ccc(F)cc4)cc3c2C1 Show InChI InChI=1S/C21H22FN3O/c1-25(2)16-8-10-20-18(12-16)17-11-15(7-9-19(17)24-20)23-21(26)13-3-5-14(22)6-4-13/h3-7,9,11,16,24H,8,10,12H2,1-2H3,(H,23,26) | PDB
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| >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Eli Lilly and Co.
Curated by PDSP Ki Database
| |
Life Sci 61: 2117-26 (1997)
Article DOI: 10.1016/s0024-3205(97)00885-0
BindingDB Entry DOI: 10.7270/Q2F47MNN |
More data for this
Ligand-Target Pair | |
D(2) dopamine receptor
(Rattus norvegicus (rat)) | BDBM85195
(CAS_5311097 | LY 344864 | NSC_5311097)Show SMILES CN(C)C1CCc2[nH]c3ccc(NC(=O)c4ccc(F)cc4)cc3c2C1 Show InChI InChI=1S/C21H22FN3O/c1-25(2)16-8-10-20-18(12-16)17-11-15(7-9-19(17)24-20)23-21(26)13-3-5-14(22)6-4-13/h3-7,9,11,16,24H,8,10,12H2,1-2H3,(H,23,26) | PDB
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| >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Eli Lilly and Co.
Curated by PDSP Ki Database
| |
Life Sci 61: 2117-26 (1997)
Article DOI: 10.1016/s0024-3205(97)00885-0
BindingDB Entry DOI: 10.7270/Q2F47MNN |
More data for this
Ligand-Target Pair | |
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