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PubMed code 9438024

Compile data set for download or QSAR
Found 94 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Platelet-activating factor receptor


(Cavia porcellus)		BDBM50062051
PNG
(1-Dimethylcarbamoyl-6-(4-fluoro-phenyl)-3-[4-(2-me...)
Show SMILES COC(=O)c1cc(cc2n(cc(C(=O)c3ccc(Cn4c(C)nc5cnccc45)cc3)c12)C(=O)N(C)C)-c1ccc(F)cc1
Show InChI InChI=1S/C34H28FN5O4/c1-20-37-28-17-36-14-13-29(28)39(20)18-21-5-7-23(8-6-21)32(41)27-19-40(34(43)38(2)3)30-16-24(22-9-11-25(35)12-10-22)15-26(31(27)30)33(42)44-4/h5-17,19H,18H2,1-4H3
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 0.150n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Binding potency against Platelet activating factor (PAF) receptor using [3H]-C18-PAF as radioligand on rabbit platelet membranes

J Med Chem 41: 74-95 (1998)


Article DOI: 10.1021/jm970389+
BindingDB Entry DOI: 10.7270/Q2MC8Z4D
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Cavia porcellus)		BDBM50062066
PNG
(3-[4-(2-Methyl-imidazo[4,5-c]pyridin-1-ylmethyl)-b...)
Show SMILES COC(=O)c1cccc2n(cc(C(=O)c3ccc(Cn4c(C)nc5cnccc45)cc3)c12)S(=O)(=O)C(C)C
Show InChI InChI=1S/C28H26N4O5S/c1-17(2)38(35,36)32-16-22(26-21(28(34)37-4)6-5-7-25(26)32)27(33)20-10-8-19(9-11-20)15-31-18(3)30-23-14-29-13-12-24(23)31/h5-14,16-17H,15H2,1-4H3
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 0.190n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Binding potency against Platelet activating factor (PAF) receptor using [3H]-C18-PAF as radioligand on rabbit platelet membranes

J Med Chem 41: 74-95 (1998)


Article DOI: 10.1021/jm970389+
BindingDB Entry DOI: 10.7270/Q2MC8Z4D
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Cavia porcellus)		BDBM50048485
PNG
((S)-4-Methyl-2-{methyl-[4-(2-methyl-imidazo[4,5-c]...)
Show SMILES CCOC(=O)[C@H](CC(C)C)N(C)S(=O)(=O)c1ccc(Cn2c(C)nc3cnccc23)cc1
Show InChI InChI=1S/C23H30N4O4S/c1-6-31-23(28)22(13-16(2)3)26(5)32(29,30)19-9-7-18(8-10-19)15-27-17(4)25-20-14-24-12-11-21(20)27/h7-12,14,16,22H,6,13,15H2,1-5H3/t22-/m0/s1
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 0.400n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
The compound was evaluated for its binding affinity against PAF receptor in rabbit platelet

J Med Chem 41: 74-95 (1998)


Article DOI: 10.1021/jm970389+
BindingDB Entry DOI: 10.7270/Q2MC8Z4D
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Cavia porcellus)		BDBM50048485
PNG
((S)-4-Methyl-2-{methyl-[4-(2-methyl-imidazo[4,5-c]...)
Show SMILES CCOC(=O)[C@H](CC(C)C)N(C)S(=O)(=O)c1ccc(Cn2c(C)nc3cnccc23)cc1
Show InChI InChI=1S/C23H30N4O4S/c1-6-31-23(28)22(13-16(2)3)26(5)32(29,30)19-9-7-18(8-10-19)15-27-17(4)25-20-14-24-12-11-21(20)27/h7-12,14,16,22H,6,13,15H2,1-5H3/t22-/m0/s1
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 0.400n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
The compound was evaluated for its binding affinity against PAF receptor in rabbit platelet

J Med Chem 41: 74-95 (1998)


Article DOI: 10.1021/jm970389+
BindingDB Entry DOI: 10.7270/Q2MC8Z4D
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Cavia porcellus)		BDBM50062069
PNG
(4-Methoxy-3-[4-(2-methyl-imidazo[4,5-c]pyridin-1-y...)
Show SMILES COC(=O)c1[nH]c2cccc(OC)c2c1C(=O)c1ccc(Cn2c(C)nc3cnccc23)cc1
Show InChI InChI=1S/C26H22N4O4/c1-15-28-19-13-27-12-11-20(19)30(15)14-16-7-9-17(10-8-16)25(31)23-22-18(5-4-6-21(22)33-2)29-24(23)26(32)34-3/h4-13,29H,14H2,1-3H3
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 0.510n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Binding potency against Platelet activating factor (PAF) receptor using [3H]-C18-PAF as radioligand on rabbit platelet membranes

J Med Chem 41: 74-95 (1998)


Article DOI: 10.1021/jm970389+
BindingDB Entry DOI: 10.7270/Q2MC8Z4D
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Cavia porcellus)		BDBM50062056
PNG
(1-Dimethylcarbamoyl-3-{2-[4-(2-methyl-imidazo[4,5-...)
Show SMILES COC(=O)c1cccc2n(cc(C(=O)Cc3ccc(cc3)-n3c(C)nc4cnccc34)c12)C(=O)N(C)C
Show InChI InChI=1S/C28H25N5O4/c1-17-30-22-15-29-13-12-23(22)33(17)19-10-8-18(9-11-19)14-25(34)21-16-32(28(36)31(2)3)24-7-5-6-20(26(21)24)27(35)37-4/h5-13,15-16H,14H2,1-4H3
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 0.630n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Binding potency against Platelet activating factor (PAF) receptor using [3H]-C18-PAF as radioligand on rabbit platelet membranes

J Med Chem 41: 74-95 (1998)


Article DOI: 10.1021/jm970389+
BindingDB Entry DOI: 10.7270/Q2MC8Z4D
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Cavia porcellus)		BDBM50062101
PNG
(4-Ethynyl-3-[3-fluoro-4-(2-methyl-imidazo[4,5-c]py...)
Show SMILES CNC(=O)n1cc(C(=O)c2ccc(Cn3c(C)nc4cnccc34)c(F)c2)c2c(cccc12)C#C
Show InChI InChI=1S/C27H20FN5O2/c1-4-17-6-5-7-24-25(17)20(15-33(24)27(35)29-3)26(34)18-8-9-19(21(28)12-18)14-32-16(2)31-22-13-30-11-10-23(22)32/h1,5-13,15H,14H2,2-3H3,(H,29,35)
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 0.630n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Binding potency against Platelet activating factor (PAF) receptor using [3H]-C18-PAF as radioligand on rabbit platelet membranes

J Med Chem 41: 74-95 (1998)


Article DOI: 10.1021/jm970389+
BindingDB Entry DOI: 10.7270/Q2MC8Z4D
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Cavia porcellus)		BDBM50062061
PNG
(1-(3,3-Dimethyl-2-oxo-butyl)-3-[4-(2-methyl-imidaz...)
Show SMILES COC(=O)c1cccc2n(CC(=O)C(C)(C)C)cc(C(=O)c3ccc(Cn4c(C)nc5cnccc45)cc3)c12
Show InChI InChI=1S/C31H30N4O4/c1-19-33-24-15-32-14-13-25(24)35(19)16-20-9-11-21(12-10-20)29(37)23-17-34(18-27(36)31(2,3)4)26-8-6-7-22(28(23)26)30(38)39-5/h6-15,17H,16,18H2,1-5H3
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 0.670n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Binding potency against Platelet activating factor (PAF) receptor using [3H]-C18-PAF as radioligand on rabbit platelet membranes

J Med Chem 41: 74-95 (1998)


Article DOI: 10.1021/jm970389+
BindingDB Entry DOI: 10.7270/Q2MC8Z4D
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Cavia porcellus)		BDBM50062045
PNG
(6-Benzofuran-2-yl-1-dimethylcarbamoyl-3-[4-(2-meth...)
Show SMILES COC(=O)c1cc(cc2n(cc(C(=O)c3ccc(Cn4c(C)nc5cnccc45)cc3)c12)C(=O)N(C)C)-c1cc2ccccc2o1
Show InChI InChI=1S/C36H29N5O5/c1-21-38-28-18-37-14-13-29(28)40(21)19-22-9-11-23(12-10-22)34(42)27-20-41(36(44)39(2)3)30-16-25(15-26(33(27)30)35(43)45-4)32-17-24-7-5-6-8-31(24)46-32/h5-18,20H,19H2,1-4H3
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 0.780n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Binding potency against Platelet activating factor (PAF) receptor using [3H]-C18-PAF as radioligand on rabbit platelet membranes

J Med Chem 41: 74-95 (1998)


Article DOI: 10.1021/jm970389+
BindingDB Entry DOI: 10.7270/Q2MC8Z4D
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Cavia porcellus)		BDBM50062082
PNG
(4-Methyl-3-[4-(2-methyl-imidazo[4,5-c]pyridin-1-yl...)
Show SMILES CN(C)C(=O)n1cc(C(=O)c2ccc(Cn3c(C)nc4cnccc34)cc2)c2c(C)cccc12
Show InChI InChI=1S/C27H25N5O2/c1-17-6-5-7-24-25(17)21(16-32(24)27(34)30(3)4)26(33)20-10-8-19(9-11-20)15-31-18(2)29-22-14-28-13-12-23(22)31/h5-14,16H,15H2,1-4H3
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 0.820n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Binding potency against Platelet activating factor (PAF) receptor using [3H]-C18-PAF as radioligand on rabbit platelet membranes

J Med Chem 41: 74-95 (1998)


Article DOI: 10.1021/jm970389+
BindingDB Entry DOI: 10.7270/Q2MC8Z4D
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Cavia porcellus)		BDBM50062113
PNG
(1-Dimethylcarbamoyl-3-[4-(2-methyl-imidazo[4,5-c]p...)
Show SMILES COC(=O)c1cccc2n(cc(C(=O)c3ccc(Cn4c(C)nc5cnccc45)cc3)c12)C(=O)N(C)C
Show InChI InChI=1S/C28H25N5O4/c1-17-30-22-14-29-13-12-23(22)32(17)15-18-8-10-19(11-9-18)26(34)21-16-33(28(36)31(2)3)24-7-5-6-20(25(21)24)27(35)37-4/h5-14,16H,15H2,1-4H3
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 0.850n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Binding potency against Platelet activating factor (PAF) receptor using [3H]-C18-PAF as radioligand on rabbit platelet membranes

J Med Chem 41: 74-95 (1998)


Article DOI: 10.1021/jm970389+
BindingDB Entry DOI: 10.7270/Q2MC8Z4D
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Cavia porcellus)		BDBM50062064
PNG
(1-Dimethylcarbamoyl-3-[4-(2-methyl-imidazo[4,5-c]p...)
Show SMILES CN(C)C(=O)n1cc(C(=O)c2ccc(Cn3c(C)nc4cnccc34)cc2)c2c(cccc12)C(=O)OCc1ccccc1
Show InChI InChI=1S/C34H29N5O4/c1-22-36-28-18-35-17-16-29(28)38(22)19-23-12-14-25(15-13-23)32(40)27-20-39(34(42)37(2)3)30-11-7-10-26(31(27)30)33(41)43-21-24-8-5-4-6-9-24/h4-18,20H,19,21H2,1-3H3
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 0.860n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Binding potency against Platelet activating factor (PAF) receptor using [3H]-C18-PAF as radioligand on rabbit platelet membranes

J Med Chem 41: 74-95 (1998)


Article DOI: 10.1021/jm970389+
BindingDB Entry DOI: 10.7270/Q2MC8Z4D
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Cavia porcellus)		BDBM50062092
PNG
((4,7-Dimethyl-1H-indol-3-yl)-[4-(2-methyl-imidazo[...)
Show SMILES Cc1nc2cnccc2n1Cc1ccc(cc1)C(=O)c1c[nH]c2c(C)ccc(C)c12
Show InChI InChI=1S/C25H22N4O/c1-15-4-5-16(2)24-23(15)20(12-27-24)25(30)19-8-6-18(7-9-19)14-29-17(3)28-21-13-26-11-10-22(21)29/h4-13,27H,14H2,1-3H3
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 0.870n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Binding potency against Platelet activating factor (PAF) receptor using [3H]-C18-PAF as radioligand on rabbit platelet membranes

J Med Chem 41: 74-95 (1998)


Article DOI: 10.1021/jm970389+
BindingDB Entry DOI: 10.7270/Q2MC8Z4D
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Cavia porcellus)		BDBM50062106
PNG
(4-Chloro-3-[4-(2-methyl-imidazo[4,5-b]pyridin-1-yl...)
Show SMILES CN(C)C(=O)n1cc(C(=O)c2ccc(Cn3c(C)nc4ncccc34)cc2)c2c(Cl)cccc12
Show InChI InChI=1S/C26H22ClN5O2/c1-16-29-25-22(8-5-13-28-25)31(16)14-17-9-11-18(12-10-17)24(33)19-15-32(26(34)30(2)3)21-7-4-6-20(27)23(19)21/h4-13,15H,14H2,1-3H3
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 0.900n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Binding potency against Platelet activating factor (PAF) receptor using [3H]-C18-PAF as radioligand on rabbit platelet membranes

J Med Chem 41: 74-95 (1998)


Article DOI: 10.1021/jm970389+
BindingDB Entry DOI: 10.7270/Q2MC8Z4D
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Cavia porcellus)		BDBM50062118
PNG
(4-Ethyl-3-[4-(2-methyl-imidazo[4,5-c]pyridin-1-ylm...)
Show SMILES CCc1cccc2n(cc(C(=O)c3ccc(Cn4c(C)nc5cnccc45)cc3)c12)C(=O)N(C)C
Show InChI InChI=1S/C28H27N5O2/c1-5-20-7-6-8-25-26(20)22(17-33(25)28(35)31(3)4)27(34)21-11-9-19(10-12-21)16-32-18(2)30-23-15-29-14-13-24(23)32/h6-15,17H,5,16H2,1-4H3
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 0.910n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Binding potency against Platelet activating factor (PAF) receptor using [3H]-C18-PAF as radioligand on rabbit platelet membranes

J Med Chem 41: 74-95 (1998)


Article DOI: 10.1021/jm970389+
BindingDB Entry DOI: 10.7270/Q2MC8Z4D
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Cavia porcellus)		BDBM50062048
PNG
(1-Dimethylcarbamoyl-3-[4-(2-methyl-benzoimidazol-1...)
Show SMILES COC(=O)c1cccc2n(cc(C(=O)c3ccc(Cn4c(C)nc5ccccc45)cc3)c12)C(=O)N(C)C
Show InChI InChI=1S/C29H26N4O4/c1-18-30-23-9-5-6-10-24(23)32(18)16-19-12-14-20(15-13-19)27(34)22-17-33(29(36)31(2)3)25-11-7-8-21(26(22)25)28(35)37-4/h5-15,17H,16H2,1-4H3
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 0.920n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Binding potency against Platelet activating factor (PAF) receptor using [3H]-C18-PAF as radioligand on rabbit platelet membranes

J Med Chem 41: 74-95 (1998)


Article DOI: 10.1021/jm970389+
BindingDB Entry DOI: 10.7270/Q2MC8Z4D
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Cavia porcellus)		BDBM50062098
PNG
(1-Dimethylcarbamoyl-3-[4-(2-methyl-imidazo[4,5-c]p...)
Show SMILES COC(=O)c1cc(cc2n(cc(C(=O)c3ccc(Cn4c(C)nc5cnccc45)cc3)c12)C(=O)N(C)C)C#Cc1ccccc1
Show InChI InChI=1S/C36H29N5O4/c1-23-38-30-20-37-17-16-31(30)40(23)21-25-12-14-27(15-13-25)34(42)29-22-41(36(44)39(2)3)32-19-26(11-10-24-8-6-5-7-9-24)18-28(33(29)32)35(43)45-4/h5-9,12-20,22H,21H2,1-4H3
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 0.950n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Binding potency against Platelet activating factor (PAF) receptor using [3H]-C18-PAF as radioligand on rabbit platelet membranes

J Med Chem 41: 74-95 (1998)


Article DOI: 10.1021/jm970389+
BindingDB Entry DOI: 10.7270/Q2MC8Z4D
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Cavia porcellus)		BDBM50062054
PNG
(4-Ethynyl-3-[3-fluoro-4-(2-methyl-imidazo[4,5-c]py...)
Show SMILES CN(C)C(=O)n1cc(C(=O)c2ccc(Cn3c(C)nc4cnccc34)c(F)c2)c2c(cccc12)C#C
Show InChI InChI=1S/C28H22FN5O2/c1-5-18-7-6-8-25-26(18)21(16-34(25)28(36)32(3)4)27(35)19-9-10-20(22(29)13-19)15-33-17(2)31-23-14-30-12-11-24(23)33/h1,6-14,16H,15H2,2-4H3
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 1n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Binding potency against Platelet activating factor (PAF) receptor using [3H]-C18-PAF as radioligand on rabbit platelet membranes

J Med Chem 41: 74-95 (1998)


Article DOI: 10.1021/jm970389+
BindingDB Entry DOI: 10.7270/Q2MC8Z4D
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Cavia porcellus)		BDBM50062054
PNG
(4-Ethynyl-3-[3-fluoro-4-(2-methyl-imidazo[4,5-c]py...)
Show SMILES CN(C)C(=O)n1cc(C(=O)c2ccc(Cn3c(C)nc4cnccc34)c(F)c2)c2c(cccc12)C#C
Show InChI InChI=1S/C28H22FN5O2/c1-5-18-7-6-8-25-26(18)21(16-34(25)28(36)32(3)4)27(35)19-9-10-20(22(29)13-19)15-33-17(2)31-23-14-30-12-11-24(23)33/h1,6-14,16H,15H2,2-4H3
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 1n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Binding potency against Platelet activating factor (PAF) receptor using [3H]-C18-PAF as radioligand on rabbit platelet membranes

J Med Chem 41: 74-95 (1998)


Article DOI: 10.1021/jm970389+
BindingDB Entry DOI: 10.7270/Q2MC8Z4D
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Cavia porcellus)		BDBM50062091
PNG
(1-(2-Ethoxy-ethyl)-3-[4-(2-methyl-imidazo[4,5-c]py...)
Show SMILES CCOCCn1cc(C(=O)c2ccc(Cn3c(C)nc4cnccc34)cc2)c2c(cccc12)C(=O)OC
Show InChI InChI=1S/C29H28N4O4/c1-4-37-15-14-32-18-23(27-22(29(35)36-3)6-5-7-26(27)32)28(34)21-10-8-20(9-11-21)17-33-19(2)31-24-16-30-13-12-25(24)33/h5-13,16,18H,4,14-15,17H2,1-3H3
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 1.10n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Binding potency against Platelet activating factor (PAF) receptor using [3H]-C18-PAF as radioligand on rabbit platelet membranes

J Med Chem 41: 74-95 (1998)


Article DOI: 10.1021/jm970389+
BindingDB Entry DOI: 10.7270/Q2MC8Z4D
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Cavia porcellus)		BDBM50062058
PNG
(6-(4-Fluoro-phenyl)-3-[4-(2-methyl-imidazo[4,5-c]p...)
Show SMILES CN(C)C(=O)n1cc(c2ccc(cc12)-c1ccc(F)cc1)S(=O)(=O)N1CCN(Cn2c(C)nc3cnccc23)CC1
Show InChI InChI=1S/C29H30FN7O3S/c1-20-32-25-17-31-11-10-26(25)37(20)19-34-12-14-35(15-13-34)41(39,40)28-18-36(29(38)33(2)3)27-16-22(6-9-24(27)28)21-4-7-23(30)8-5-21/h4-11,16-18H,12-15,19H2,1-3H3
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 1.20n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Binding potency against Platelet activating factor (PAF) receptor using [3H]-C18-PAF as radioligand on rabbit platelet membranes

J Med Chem 41: 74-95 (1998)


Article DOI: 10.1021/jm970389+
BindingDB Entry DOI: 10.7270/Q2MC8Z4D
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Cavia porcellus)		BDBM50062049
PNG
(CHEMBL367964 | [7-(4-Fluoro-phenyl)-1H-indol-3-yl]...)
Show SMILES Cc1nc2cnccc2n1Cc1ccc(cc1)C(=O)c1c[nH]c2c(cccc12)-c1ccc(F)cc1
Show InChI InChI=1S/C29H21FN4O/c1-18-33-26-16-31-14-13-27(26)34(18)17-19-5-7-21(8-6-19)29(35)25-15-32-28-23(3-2-4-24(25)28)20-9-11-22(30)12-10-20/h2-16,32H,17H2,1H3
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 1.30n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Binding potency against Platelet activating factor (PAF) receptor using [3H]-C18-PAF as radioligand on rabbit platelet membranes

J Med Chem 41: 74-95 (1998)


Article DOI: 10.1021/jm970389+
BindingDB Entry DOI: 10.7270/Q2MC8Z4D
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Cavia porcellus)		BDBM50062084
PNG
(4-Ethynyl-3-[4-(2-methyl-imidazo[4,5-c]pyridin-1-y...)
Show SMILES CN(C)C(=O)n1cc(C(=O)c2ccc(Cn3c(C)nc4cnccc34)cc2)c2c(cccc12)C#C
Show InChI InChI=1S/C28H23N5O2/c1-5-20-7-6-8-25-26(20)22(17-33(25)28(35)31(3)4)27(34)21-11-9-19(10-12-21)16-32-18(2)30-23-15-29-14-13-24(23)32/h1,6-15,17H,16H2,2-4H3
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 1.30n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Binding potency against Platelet activating factor (PAF) receptor using [3H]-C18-PAF as radioligand on rabbit platelet membranes

J Med Chem 41: 74-95 (1998)


Article DOI: 10.1021/jm970389+
BindingDB Entry DOI: 10.7270/Q2MC8Z4D
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Cavia porcellus)		BDBM50062110
PNG
(1-Isopropyl-3-[4-(2-methyl-imidazo[4,5-c]pyridin-1...)
Show SMILES COC(=O)c1cccc2n(cc(C(=O)c3ccc(Cn4c(C)nc5cnccc45)cc3)c12)C(C)C
Show InChI InChI=1S/C28H26N4O3/c1-17(2)31-16-22(26-21(28(34)35-4)6-5-7-25(26)31)27(33)20-10-8-19(9-11-20)15-32-18(3)30-23-14-29-13-12-24(23)32/h5-14,16-17H,15H2,1-4H3
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 1.30n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Binding potency against Platelet activating factor (PAF) receptor using [3H]-C18-PAF as radioligand on rabbit platelet membranes

J Med Chem 41: 74-95 (1998)


Article DOI: 10.1021/jm970389+
BindingDB Entry DOI: 10.7270/Q2MC8Z4D
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Cavia porcellus)		BDBM50062128
PNG
(6-Bromo-1-dimethylcarbamoyl-3-[4-(2-methyl-imidazo...)
Show SMILES COC(=O)c1cc(Br)cc2n(cc(C(=O)c3ccc(Cn4c(C)nc5cnccc45)cc3)c12)C(=O)N(C)C
Show InChI InChI=1S/C28H24BrN5O4/c1-16-31-22-13-30-10-9-23(22)33(16)14-17-5-7-18(8-6-17)26(35)21-15-34(28(37)32(2)3)24-12-19(29)11-20(25(21)24)27(36)38-4/h5-13,15H,14H2,1-4H3
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 1.40n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Binding potency against Platelet activating factor (PAF) receptor using [3H]-C18-PAF as radioligand on rabbit platelet membranes

J Med Chem 41: 74-95 (1998)


Article DOI: 10.1021/jm970389+
BindingDB Entry DOI: 10.7270/Q2MC8Z4D
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Cavia porcellus)		BDBM50062126
PNG
(1-Carbamoyl-3-[4-(2-methyl-imidazo[4,5-c]pyridin-1...)
Show SMILES COC(=O)c1cccc2n(cc(C(=O)c3ccc(Cn4c(C)nc5cnccc45)cc3)c12)C(N)=O
Show InChI InChI=1S/C26H21N5O4/c1-15-29-20-12-28-11-10-21(20)30(15)13-16-6-8-17(9-7-16)24(32)19-14-31(26(27)34)22-5-3-4-18(23(19)22)25(33)35-2/h3-12,14H,13H2,1-2H3,(H2,27,34)
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 1.5n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Binding potency against Platelet activating factor (PAF) receptor using [3H]-C18-PAF as radioligand on rabbit platelet membranes

J Med Chem 41: 74-95 (1998)


Article DOI: 10.1021/jm970389+
BindingDB Entry DOI: 10.7270/Q2MC8Z4D
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Cavia porcellus)		BDBM50062107
PNG
(1-Methylcarbamoyl-3-[4-(2-methyl-imidazo[4,5-c]pyr...)
Show SMILES CNC(=O)n1cc(C(=O)c2ccc(Cn3c(C)nc4cnccc34)cc2)c2c(cccc12)C(=O)OC
Show InChI InChI=1S/C27H23N5O4/c1-16-30-21-13-29-12-11-22(21)31(16)14-17-7-9-18(10-8-17)25(33)20-15-32(27(35)28-2)23-6-4-5-19(24(20)23)26(34)36-3/h4-13,15H,14H2,1-3H3,(H,28,35)
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 1.5n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Binding potency against Platelet activating factor (PAF) receptor using [3H]-C18-PAF as radioligand on rabbit platelet membranes

J Med Chem 41: 74-95 (1998)


Article DOI: 10.1021/jm970389+
BindingDB Entry DOI: 10.7270/Q2MC8Z4D
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Cavia porcellus)		BDBM50062108
PNG
(4-Ethynyl-3-{[3-fluoro-4-(2-methyl-imidazo[4,5-c]p...)
Show SMILES CN(C)C(=O)n1cc(C(O)c2ccc(Cn3c(C)nc4cnccc34)c(F)c2)c2c(cccc12)C#C
Show InChI InChI=1S/C28H24FN5O2/c1-5-18-7-6-8-25-26(18)21(16-34(25)28(36)32(3)4)27(35)19-9-10-20(22(29)13-19)15-33-17(2)31-23-14-30-12-11-24(23)33/h1,6-14,16,27,35H,15H2,2-4H3
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 1.5n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Binding potency against Platelet activating factor (PAF) receptor using [3H]-C18-PAF as radioligand on rabbit platelet membranes

J Med Chem 41: 74-95 (1998)


Article DOI: 10.1021/jm970389+
BindingDB Entry DOI: 10.7270/Q2MC8Z4D
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Cavia porcellus)		BDBM50062081
PNG
(3-[4-(2-Methyl-benzoimidazol-1-ylmethyl)-benzoyl]-...)
Show SMILES COC(=O)c1cccc2n(cc(C(=O)c3ccc(Cn4c(C)nc5ccccc45)cc3)c12)C(=O)N1CCCC1
Show InChI InChI=1S/C31H28N4O4/c1-20-32-25-9-3-4-10-26(25)34(20)18-21-12-14-22(15-13-21)29(36)24-19-35(31(38)33-16-5-6-17-33)27-11-7-8-23(28(24)27)30(37)39-2/h3-4,7-15,19H,5-6,16-18H2,1-2H3
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 1.70n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Binding potency against Platelet activating factor (PAF) receptor using [3H]-C18-PAF as radioligand on rabbit platelet membranes

J Med Chem 41: 74-95 (1998)


Article DOI: 10.1021/jm970389+
BindingDB Entry DOI: 10.7270/Q2MC8Z4D
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Cavia porcellus)		BDBM50062121
PNG
(3-[4-(4-Chloro-2-methyl-imidazo[4,5-c]pyridin-1-yl...)
Show SMILES COC(=O)c1cccc2n(cc(C(=O)c3ccc(Cn4c(C)nc5c(Cl)nccc45)cc3)c12)C(=O)N(C)C
Show InChI InChI=1S/C28H24ClN5O4/c1-16-31-24-22(12-13-30-26(24)29)33(16)14-17-8-10-18(11-9-17)25(35)20-15-34(28(37)32(2)3)21-7-5-6-19(23(20)21)27(36)38-4/h5-13,15H,14H2,1-4H3
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 1.80n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Binding potency against Platelet activating factor (PAF) receptor using [3H]-C18-PAF as radioligand on rabbit platelet membranes

J Med Chem 41: 74-95 (1998)


Article DOI: 10.1021/jm970389+
BindingDB Entry DOI: 10.7270/Q2MC8Z4D
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Cavia porcellus)		BDBM50062054
PNG
(4-Ethynyl-3-[3-fluoro-4-(2-methyl-imidazo[4,5-c]py...)
Show SMILES CN(C)C(=O)n1cc(C(=O)c2ccc(Cn3c(C)nc4cnccc34)c(F)c2)c2c(cccc12)C#C
Show InChI InChI=1S/C28H22FN5O2/c1-5-18-7-6-8-25-26(18)21(16-34(25)28(36)32(3)4)27(35)19-9-10-20(22(29)13-19)15-33-17(2)31-23-14-30-12-11-24(23)33/h1,6-14,16H,15H2,2-4H3
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 1.80n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
The compound was evaluated for its binding affinity against PAF receptor in rabbit platelet

J Med Chem 41: 74-95 (1998)


Article DOI: 10.1021/jm970389+
BindingDB Entry DOI: 10.7270/Q2MC8Z4D
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Cavia porcellus)		BDBM50062077
PNG
(4-Benzoylamino-3-[4-(2-methyl-imidazo[4,5-c]pyridi...)
Show SMILES CN(C)C(=O)n1cc(C(=O)c2ccc(Cn3c(C)nc4cnccc34)cc2)c2c(NC(=O)c3ccccc3)cccc12
Show InChI InChI=1S/C33H28N6O3/c1-21-35-27-18-34-17-16-28(27)38(21)19-22-12-14-23(15-13-22)31(40)25-20-39(33(42)37(2)3)29-11-7-10-26(30(25)29)36-32(41)24-8-5-4-6-9-24/h4-18,20H,19H2,1-3H3,(H,36,41)
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 2n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Binding potency against Platelet activating factor (PAF) receptor using [3H]-C18-PAF as radioligand on rabbit platelet membranes

J Med Chem 41: 74-95 (1998)


Article DOI: 10.1021/jm970389+
BindingDB Entry DOI: 10.7270/Q2MC8Z4D
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Cavia porcellus)		BDBM50062095
PNG
(4-Methyl-3-{2-[4-(2-methyl-imidazo[4,5-c]pyridin-1...)
Show SMILES CN(C)C(=O)n1cc(C(=O)CN2CCC(CC2)n2c(C)nc3cnccc23)c2c(C)cccc12
Show InChI InChI=1S/C26H30N6O2/c1-17-6-5-7-23-25(17)20(15-31(23)26(34)29(3)4)24(33)16-30-12-9-19(10-13-30)32-18(2)28-21-14-27-11-8-22(21)32/h5-8,11,14-15,19H,9-10,12-13,16H2,1-4H3
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 2n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Binding potency against Platelet activating factor (PAF) receptor using [3H]-C18-PAF as radioligand on rabbit platelet membranes

J Med Chem 41: 74-95 (1998)


Article DOI: 10.1021/jm970389+
BindingDB Entry DOI: 10.7270/Q2MC8Z4D
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Cavia porcellus)		BDBM50062042
PNG
(4-Methoxy-3-[4-(2-methyl-imidazo[4,5-c]pyridin-1-y...)
Show SMILES COc1cccc2n(cc(C(=O)c3ccc(Cn4c(C)nc5cnccc45)cc3)c12)C(=O)N(C)C
Show InChI InChI=1S/C27H25N5O3/c1-17-29-21-14-28-13-12-22(21)31(17)15-18-8-10-19(11-9-18)26(33)20-16-32(27(34)30(2)3)23-6-5-7-24(35-4)25(20)23/h5-14,16H,15H2,1-4H3
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 2n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Binding potency against Platelet activating factor (PAF) receptor using [3H]-C18-PAF as radioligand on rabbit platelet membranes

J Med Chem 41: 74-95 (1998)


Article DOI: 10.1021/jm970389+
BindingDB Entry DOI: 10.7270/Q2MC8Z4D
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Cavia porcellus)		BDBM50062093
PNG
((4-Ethynyl-1H-indol-3-yl)-[3-fluoro-4-(2-methyl-im...)
Show SMILES Cc1nc2cnccc2n1Cc1ccc(cc1F)C(=O)c1c[nH]c2cccc(C#C)c12
Show InChI InChI=1S/C25H17FN4O/c1-3-16-5-4-6-21-24(16)19(12-28-21)25(31)17-7-8-18(20(26)11-17)14-30-15(2)29-22-13-27-10-9-23(22)30/h1,4-13,28H,14H2,2H3
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 2.20n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Binding potency against Platelet activating factor (PAF) receptor using [3H]-C18-PAF as radioligand on rabbit platelet membranes

J Med Chem 41: 74-95 (1998)


Article DOI: 10.1021/jm970389+
BindingDB Entry DOI: 10.7270/Q2MC8Z4D
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Cavia porcellus)		BDBM50062112
PNG
(6-(4-Fluoro-phenyl)-3-[4-(2-methyl-imidazo[4,5-c]p...)
Show SMILES CN(C)C(=O)n1cc(C(=O)c2ccc(Cn3c(C)nc4cnccc34)cc2)c2ccc(cc12)-c1ccc(F)cc1
Show InChI InChI=1S/C32H26FN5O2/c1-20-35-28-17-34-15-14-29(28)37(20)18-21-4-6-23(7-5-21)31(39)27-19-38(32(40)36(2)3)30-16-24(10-13-26(27)30)22-8-11-25(33)12-9-22/h4-17,19H,18H2,1-3H3
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 2.30n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Binding potency against Platelet activating factor (PAF) receptor using [3H]-C18-PAF as radioligand on rabbit platelet membranes

J Med Chem 41: 74-95 (1998)


Article DOI: 10.1021/jm970389+
BindingDB Entry DOI: 10.7270/Q2MC8Z4D
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Cavia porcellus)		BDBM50062071
PNG
(1-Dimethylcarbamoyl-3-[4-(2-methyl-imidazo[4,5-c]p...)
Show SMILES COC(=O)c1cccc2n(cc(C(=O)C3CCC(Cn4c(C)nc5cnccc45)CC3)c12)C(=O)N(C)C |(5.2,-3.63,;5.2,-5.17,;3.88,-5.94,;2.54,-5.18,;3.88,-7.46,;2.55,-8.26,;2.55,-9.82,;3.88,-10.59,;5.23,-9.82,;6.71,-10.3,;7.63,-9.02,;6.71,-7.76,;7.18,-6.29,;6.41,-4.95,;8.71,-6.13,;9.75,-5.41,;11.56,-5.59,;11.95,-4.1,;12.85,-2.85,;14.38,-2.69,;15.47,-3.77,;15.24,-5.3,;16.83,-3.06,;16.57,-1.55,;17.53,-.36,;16.98,1.06,;15.46,1.3,;14.52,.11,;15.06,-1.31,;10.83,-4.82,;9.11,-4.64,;5.23,-8.26,;7.2,-11.75,;6.42,-13.08,;8.72,-11.91,;9.35,-13.31,;9.63,-10.67,)|
Show InChI InChI=1S/C28H31N5O4/c1-17-30-22-14-29-13-12-23(22)32(17)15-18-8-10-19(11-9-18)26(34)21-16-33(28(36)31(2)3)24-7-5-6-20(25(21)24)27(35)37-4/h5-7,12-14,16,18-19H,8-11,15H2,1-4H3
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 2.40n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Binding potency against Platelet activating factor (PAF) receptor using [3H]-C18-PAF as radioligand on rabbit platelet membranes

J Med Chem 41: 74-95 (1998)


Article DOI: 10.1021/jm970389+
BindingDB Entry DOI: 10.7270/Q2MC8Z4D
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Cavia porcellus)		BDBM50062127
PNG
(6-(4-Fluoro-phenyl)-3-[4-(2-methyl-imidazo[4,5-c]p...)
Show SMILES CN(C)C(=O)n1cc(C(=O)N2CCC(Cn3c(C)nc4cnccc34)CC2)c2ccc(cc12)-c1ccc(F)cc1
Show InChI InChI=1S/C31H31FN6O2/c1-20-34-27-17-33-13-10-28(27)37(20)18-21-11-14-36(15-12-21)30(39)26-19-38(31(40)35(2)3)29-16-23(6-9-25(26)29)22-4-7-24(32)8-5-22/h4-10,13,16-17,19,21H,11-12,14-15,18H2,1-3H3
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 2.5n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Binding potency against Platelet activating factor (PAF) receptor using [3H]-C18-PAF as radioligand on rabbit platelet membranes

J Med Chem 41: 74-95 (1998)


Article DOI: 10.1021/jm970389+
BindingDB Entry DOI: 10.7270/Q2MC8Z4D
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Cavia porcellus)		BDBM50062102
PNG
(1-Dimethylcarbamoyl-3-[4-(2-methyl-imidazo[4,5-b]p...)
Show SMILES COC(=O)c1cccc2n(cc(C(=O)c3ccc(Cn4c(C)nc5ncccc45)cc3)c12)C(=O)N(C)C
Show InChI InChI=1S/C28H25N5O4/c1-17-30-26-23(9-6-14-29-26)32(17)15-18-10-12-19(13-11-18)25(34)21-16-33(28(36)31(2)3)22-8-5-7-20(24(21)22)27(35)37-4/h5-14,16H,15H2,1-4H3
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 2.90n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Binding potency against Platelet activating factor (PAF) receptor using [3H]-C18-PAF as radioligand on rabbit platelet membranes

J Med Chem 41: 74-95 (1998)


Article DOI: 10.1021/jm970389+
BindingDB Entry DOI: 10.7270/Q2MC8Z4D
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Cavia porcellus)		BDBM50062125
PNG
(3-[4-(2-Methyl-imidazo[4,5-c]pyridin-1-ylmethyl)-b...)
Show SMILES COC(=O)c1ccc(C(=O)OC)c2c(c[nH]c12)C(=O)c1ccc(Cn2c(C)nc3cnccc23)cc1
Show InChI InChI=1S/C27H22N4O5/c1-15-30-21-13-28-11-10-22(21)31(15)14-16-4-6-17(7-5-16)25(32)20-12-29-24-19(27(34)36-3)9-8-18(23(20)24)26(33)35-2/h4-13,29H,14H2,1-3H3
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 2.90n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Binding potency against Platelet activating factor (PAF) receptor using [3H]-C18-PAF as radioligand on rabbit platelet membranes

J Med Chem 41: 74-95 (1998)


Article DOI: 10.1021/jm970389+
BindingDB Entry DOI: 10.7270/Q2MC8Z4D
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Cavia porcellus)		BDBM50062067
PNG
(4-(4-Fluoro-phenyl)-3-[4-(2-methyl-imidazo[4,5-c]p...)
Show SMILES CN(C)C(=O)n1cc(C(=O)c2ccc(Cn3c(C)nc4cnccc34)cc2)c2c(cccc12)-c1ccc(F)cc1
Show InChI InChI=1S/C32H26FN5O2/c1-20-35-27-17-34-16-15-28(27)37(20)18-21-7-9-23(10-8-21)31(39)26-19-38(32(40)36(2)3)29-6-4-5-25(30(26)29)22-11-13-24(33)14-12-22/h4-17,19H,18H2,1-3H3
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 2.90n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Binding potency against Platelet activating factor (PAF) receptor using [3H]-C18-PAF as radioligand on rabbit platelet membranes

J Med Chem 41: 74-95 (1998)


Article DOI: 10.1021/jm970389+
BindingDB Entry DOI: 10.7270/Q2MC8Z4D
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Cavia porcellus)		BDBM50062052
PNG
(4-(4-Fluoro-phenyl)-3-[6-(2-methyl-imidazo[4,5-c]p...)
Show SMILES CN(C)C(=O)n1cc(C(=O)CCCCCn2c(C)nc3cnccc23)c2c(cccc12)-c1ccc(F)cc1
Show InChI InChI=1S/C30H30FN5O2/c1-20-33-25-18-32-16-15-26(25)35(20)17-6-4-5-10-28(37)24-19-36(30(38)34(2)3)27-9-7-8-23(29(24)27)21-11-13-22(31)14-12-21/h7-9,11-16,18-19H,4-6,10,17H2,1-3H3
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 3.20n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Binding potency against Platelet activating factor (PAF) receptor using [3H]-C18-PAF as radioligand on rabbit platelet membranes

J Med Chem 41: 74-95 (1998)


Article DOI: 10.1021/jm970389+
BindingDB Entry DOI: 10.7270/Q2MC8Z4D
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Cavia porcellus)		BDBM50062090
PNG
(6-(4-Fluoro-phenyl)-3-[4-(2-methyl-imidazo[4,5-c]p...)
Show SMILES CN(C)C(=O)n1cc(C(=O)N2CCC(CC2)n2c(C)nc3cnccc23)c2ccc(cc12)-c1ccc(F)cc1
Show InChI InChI=1S/C30H29FN6O2/c1-19-33-26-17-32-13-10-27(26)37(19)23-11-14-35(15-12-23)29(38)25-18-36(30(39)34(2)3)28-16-21(6-9-24(25)28)20-4-7-22(31)8-5-20/h4-10,13,16-18,23H,11-12,14-15H2,1-3H3
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 3.40n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Binding potency against Platelet activating factor (PAF) receptor using [3H]-C18-PAF as radioligand on rabbit platelet membranes

J Med Chem 41: 74-95 (1998)


Article DOI: 10.1021/jm970389+
BindingDB Entry DOI: 10.7270/Q2MC8Z4D
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Cavia porcellus)		BDBM50062074
PNG
(CHEMBL174104 | Dimethyl-carbamic acid 1-dimethylca...)
Show SMILES CN(C)C(=O)Oc1cccc2n(cc(C(=O)c3ccc(Cn4c(C)nc5cnccc45)cc3)c12)C(=O)N(C)C
Show InChI InChI=1S/C29H28N6O4/c1-18-31-22-15-30-14-13-23(22)34(18)16-19-9-11-20(12-10-19)27(36)21-17-35(28(37)32(2)3)24-7-6-8-25(26(21)24)39-29(38)33(4)5/h6-15,17H,16H2,1-5H3
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 3.60n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Binding potency against Platelet activating factor (PAF) receptor using [3H]-C18-PAF as radioligand on rabbit platelet membranes

J Med Chem 41: 74-95 (1998)


Article DOI: 10.1021/jm970389+
BindingDB Entry DOI: 10.7270/Q2MC8Z4D
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Cavia porcellus)		BDBM50062086
PNG
(1-Acetoxymethyl-3-{(R)-7-[1-dimethylcarbamoyl-6-(4...)
Show SMILES CN(C)C(=O)n1cc(C(=O)c2ccn3[C@H](SCc23)c2ccc[n+](COC(C)=O)c2)c2ccc(cc12)-c1ccc(F)cc1
Show InChI InChI=1S/C32H28FN4O4S/c1-20(38)41-19-35-13-4-5-23(16-35)31-36-14-12-26(29(36)18-42-31)30(39)27-17-37(32(40)34(2)3)28-15-22(8-11-25(27)28)21-6-9-24(33)10-7-21/h4-17,31H,18-19H2,1-3H3/q+1/t31-/m1/s1
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 3.80n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
The compound was evaluated for its binding affinity against PAF receptor in rabbit platelet

J Med Chem 41: 74-95 (1998)


Article DOI: 10.1021/jm970389+
BindingDB Entry DOI: 10.7270/Q2MC8Z4D
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Cavia porcellus)		BDBM50062086
PNG
(1-Acetoxymethyl-3-{(R)-7-[1-dimethylcarbamoyl-6-(4...)
Show SMILES CN(C)C(=O)n1cc(C(=O)c2ccn3[C@H](SCc23)c2ccc[n+](COC(C)=O)c2)c2ccc(cc12)-c1ccc(F)cc1
Show InChI InChI=1S/C32H28FN4O4S/c1-20(38)41-19-35-13-4-5-23(16-35)31-36-14-12-26(29(36)18-42-31)30(39)27-17-37(32(40)34(2)3)28-15-22(8-11-25(27)28)21-6-9-24(33)10-7-21/h4-17,31H,18-19H2,1-3H3/q+1/t31-/m1/s1
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 3.80n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
The compound was evaluated for its binding affinity against PAF receptor in rabbit platelet

J Med Chem 41: 74-95 (1998)


Article DOI: 10.1021/jm970389+
BindingDB Entry DOI: 10.7270/Q2MC8Z4D
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Cavia porcellus)		BDBM50062119
PNG
(1-Dimethylcarbamoyl-3-[4-(2-methyl-4-oxo-4,5-dihyd...)
Show SMILES COC(=O)c1cccc2n(cc(C(=O)c3ccc(Cn4c(C)nc5c4cc[nH]c5=O)cc3)c12)C(=O)N(C)C
Show InChI InChI=1S/C28H25N5O5/c1-16-30-24-22(12-13-29-26(24)35)32(16)14-17-8-10-18(11-9-17)25(34)20-15-33(28(37)31(2)3)21-7-5-6-19(23(20)21)27(36)38-4/h5-13,15H,14H2,1-4H3,(H,29,35)
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 4n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Binding potency against Platelet activating factor (PAF) receptor using [3H]-C18-PAF as radioligand on rabbit platelet membranes

J Med Chem 41: 74-95 (1998)


Article DOI: 10.1021/jm970389+
BindingDB Entry DOI: 10.7270/Q2MC8Z4D
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Cavia porcellus)		BDBM50062062
PNG
(1-Dimethylsulfamoyl-3-[4-(2-methyl-imidazo[4,5-c]p...)
Show SMILES COC(=O)c1cccc2n(cc(C(=O)c3ccc(Cn4c(C)nc5cnccc45)cc3)c12)S(=O)(=O)N(C)C
Show InChI InChI=1S/C27H25N5O5S/c1-17-29-22-14-28-13-12-23(22)31(17)15-18-8-10-19(11-9-18)26(33)21-16-32(38(35,36)30(2)3)24-7-5-6-20(25(21)24)27(34)37-4/h5-14,16H,15H2,1-4H3
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 4.30n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Binding potency against Platelet activating factor (PAF) receptor using [3H]-C18-PAF as radioligand on rabbit platelet membranes

J Med Chem 41: 74-95 (1998)


Article DOI: 10.1021/jm970389+
BindingDB Entry DOI: 10.7270/Q2MC8Z4D
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Cavia porcellus)		BDBM50062060
PNG
(1-Dimethylcarbamoylmethyl-3-[4-(2-methyl-imidazo[4...)
Show SMILES COC(=O)c1cccc2n(CC(=O)N(C)C)cc(C(=O)c3ccc(Cn4c(C)nc5cnccc45)cc3)c12
Show InChI InChI=1S/C29H27N5O4/c1-18-31-23-14-30-13-12-24(23)34(18)15-19-8-10-20(11-9-19)28(36)22-16-33(17-26(35)32(2)3)25-7-5-6-21(27(22)25)29(37)38-4/h5-14,16H,15,17H2,1-4H3
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 4.40n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Binding potency against Platelet activating factor (PAF) receptor using [3H]-C18-PAF as radioligand on rabbit platelet membranes

J Med Chem 41: 74-95 (1998)


Article DOI: 10.1021/jm970389+
BindingDB Entry DOI: 10.7270/Q2MC8Z4D
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Cavia porcellus)		BDBM50062124
PNG
(1-Dimethylcarbamoyl-3-[4-(2-methyl-imidazo[4,5-c]p...)
Show SMILES CC(C)OC(=O)c1cccc2n(cc(C(=O)c3ccc(Cn4c(C)nc5cnccc45)cc3)c12)C(=O)N(C)C
Show InChI InChI=1S/C30H29N5O4/c1-18(2)39-29(37)22-7-6-8-26-27(22)23(17-35(26)30(38)33(4)5)28(36)21-11-9-20(10-12-21)16-34-19(3)32-24-15-31-14-13-25(24)34/h6-15,17-18H,16H2,1-5H3
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 4.70n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Binding potency against Platelet activating factor (PAF) receptor using [3H]-C18-PAF as radioligand on rabbit platelet membranes

J Med Chem 41: 74-95 (1998)


Article DOI: 10.1021/jm970389+
BindingDB Entry DOI: 10.7270/Q2MC8Z4D
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Cavia porcellus)		BDBM50062104
PNG
(1-Dimethylcarbamoyl-3-[3-fluoro-4-(2-methyl-imidaz...)
Show SMILES COC(=O)c1cccc2n(cc(C(=O)c3ccc(Cn4c(C)nc5cnccc45)c(F)c3)c12)C(=O)N(C)C
Show InChI InChI=1S/C28H24FN5O4/c1-16-31-22-13-30-11-10-23(22)33(16)14-18-9-8-17(12-21(18)29)26(35)20-15-34(28(37)32(2)3)24-7-5-6-19(25(20)24)27(36)38-4/h5-13,15H,14H2,1-4H3
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 5n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Binding potency against Platelet activating factor (PAF) receptor using [3H]-C18-PAF as radioligand on rabbit platelet membranes

J Med Chem 41: 74-95 (1998)


Article DOI: 10.1021/jm970389+
BindingDB Entry DOI: 10.7270/Q2MC8Z4D
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Cavia porcellus)		BDBM50062099
PNG
(4-Fluoro-3-[4-(2-methyl-imidazo[4,5-c]pyridin-1-yl...)
Show SMILES CN(C)C(=O)n1cc(C(=O)c2ccc(Cn3c(C)nc4cnccc34)cc2)c2c(F)cccc12
Show InChI InChI=1S/C26H22FN5O2/c1-16-29-21-13-28-12-11-22(21)31(16)14-17-7-9-18(10-8-17)25(33)19-15-32(26(34)30(2)3)23-6-4-5-20(27)24(19)23/h4-13,15H,14H2,1-3H3
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 5.10n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Binding potency against Platelet activating factor (PAF) receptor using [3H]-C18-PAF as radioligand on rabbit platelet membranes

J Med Chem 41: 74-95 (1998)


Article DOI: 10.1021/jm970389+
BindingDB Entry DOI: 10.7270/Q2MC8Z4D
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Cavia porcellus)		BDBM50062114
PNG
(1-Dimethylcarbamoyl-3-[4-(2-methyl-imidazo[4,5-c]p...)
Show SMILES CCOC(=O)c1cccc2n(cc(C(=O)c3ccc(Cn4c(C)nc5cnccc45)cc3)c12)C(=O)N(C)C
Show InChI InChI=1S/C29H27N5O4/c1-5-38-28(36)21-7-6-8-25-26(21)22(17-34(25)29(37)32(3)4)27(35)20-11-9-19(10-12-20)16-33-18(2)31-23-15-30-14-13-24(23)33/h6-15,17H,5,16H2,1-4H3
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 5.20n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Binding potency against Platelet activating factor (PAF) receptor using [3H]-C18-PAF as radioligand on rabbit platelet membranes

J Med Chem 41: 74-95 (1998)


Article DOI: 10.1021/jm970389+
BindingDB Entry DOI: 10.7270/Q2MC8Z4D
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Cavia porcellus)		BDBM50062059
PNG
(4-Chloro-3-[4-(2-methyl-imidazo[4,5-c]pyridin-1-yl...)
Show SMILES CN(C)C(=O)n1cc(C(=O)c2ccc(Cn3c(C)nc4cnccc34)cc2)c2c(Cl)cccc12
Show InChI InChI=1S/C26H22ClN5O2/c1-16-29-21-13-28-12-11-22(21)31(16)14-17-7-9-18(10-8-17)25(33)19-15-32(26(34)30(2)3)23-6-4-5-20(27)24(19)23/h4-13,15H,14H2,1-3H3
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 5.40n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Binding potency against Platelet activating factor (PAF) receptor using [3H]-C18-PAF as radioligand on rabbit platelet membranes

J Med Chem 41: 74-95 (1998)


Article DOI: 10.1021/jm970389+
BindingDB Entry DOI: 10.7270/Q2MC8Z4D
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Cavia porcellus)		BDBM50062041
PNG
(3-[4-(2-Methyl-imidazo[4,5-c]pyridin-1-ylmethyl)-b...)
Show SMILES COC(=O)c1cccc2[nH]cc(C(=O)c3ccc(Cn4c(C)nc5cnccc45)cc3)c12
Show InChI InChI=1S/C25H20N4O3/c1-15-28-21-13-26-11-10-22(21)29(15)14-16-6-8-17(9-7-16)24(30)19-12-27-20-5-3-4-18(23(19)20)25(31)32-2/h3-13,27H,14H2,1-2H3
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 6n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Binding potency against Platelet activating factor (PAF) receptor using [3H]-C18-PAF as radioligand on rabbit platelet membranes

J Med Chem 41: 74-95 (1998)


Article DOI: 10.1021/jm970389+
BindingDB Entry DOI: 10.7270/Q2MC8Z4D
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Cavia porcellus)		BDBM50062075
PNG
(1-Dimethylcarbamoyl-3-[6-(2-methyl-imidazo[4,5-c]p...)
Show SMILES COC(=O)c1cccc2n(cc(C(=O)CCCCCn3c(C)nc4cnccc34)c12)C(=O)N(C)C
Show InChI InChI=1S/C26H29N5O4/c1-17-28-20-15-27-13-12-21(20)30(17)14-7-5-6-11-23(32)19-16-31(26(34)29(2)3)22-10-8-9-18(24(19)22)25(33)35-4/h8-10,12-13,15-16H,5-7,11,14H2,1-4H3
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 6.10n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Binding potency against Platelet activating factor (PAF) receptor using [3H]-C18-PAF as radioligand on rabbit platelet membranes

J Med Chem 41: 74-95 (1998)


Article DOI: 10.1021/jm970389+
BindingDB Entry DOI: 10.7270/Q2MC8Z4D
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Cavia porcellus)		BDBM50062065
PNG
(4-Hydroxy-3-[4-(2-methyl-imidazo[4,5-c]pyridin-1-y...)
Show SMILES CN(C)C(=O)n1cc(C(=O)c2ccc(Cn3c(C)nc4cnccc34)cc2)c2c(O)cccc12
Show InChI InChI=1S/C26H23N5O3/c1-16-28-20-13-27-12-11-21(20)30(16)14-17-7-9-18(10-8-17)25(33)19-15-31(26(34)29(2)3)22-5-4-6-23(32)24(19)22/h4-13,15,32H,14H2,1-3H3
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 6.10n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Binding potency against Platelet activating factor (PAF) receptor using [3H]-C18-PAF as radioligand on rabbit platelet membranes

J Med Chem 41: 74-95 (1998)


Article DOI: 10.1021/jm970389+
BindingDB Entry DOI: 10.7270/Q2MC8Z4D
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Cavia porcellus)		BDBM50062072
PNG
(3-[4-(2-Methyl-imidazo[4,5-c]pyridin-1-ylmethyl)-b...)
Show SMILES CN(C)C(=O)n1cc(C(=O)c2ccc(Cn3c(C)nc4cnccc34)cc2)c2ccccc12
Show InChI InChI=1S/C26H23N5O2/c1-17-28-22-14-27-13-12-24(22)30(17)15-18-8-10-19(11-9-18)25(32)21-16-31(26(33)29(2)3)23-7-5-4-6-20(21)23/h4-14,16H,15H2,1-3H3
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 6.80n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Binding potency against Platelet activating factor (PAF) receptor using [3H]-C18-PAF as radioligand on rabbit platelet membranes

J Med Chem 41: 74-95 (1998)


Article DOI: 10.1021/jm970389+
BindingDB Entry DOI: 10.7270/Q2MC8Z4D
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Cavia porcellus)		BDBM50062063
PNG
(1-Dimethylcarbamoyl-3-[5-(2-methyl-imidazo[4,5-c]p...)
Show SMILES COC(=O)c1cccc2n(cc(C(=O)c3ccc(Cn4c(C)nc5cnccc45)s3)c12)C(=O)N(C)C
Show InChI InChI=1S/C26H23N5O4S/c1-15-28-19-12-27-11-10-20(19)30(15)13-16-8-9-22(36-16)24(32)18-14-31(26(34)29(2)3)21-7-5-6-17(23(18)21)25(33)35-4/h5-12,14H,13H2,1-4H3
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 8.20n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Binding potency against Platelet activating factor (PAF) receptor using [3H]-C18-PAF as radioligand on rabbit platelet membranes

J Med Chem 41: 74-95 (1998)


Article DOI: 10.1021/jm970389+
BindingDB Entry DOI: 10.7270/Q2MC8Z4D
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Cavia porcellus)		BDBM50062115
PNG
(1-Dimethylcarbamoyl-3-[7-(2-methyl-imidazo[4,5-c]p...)
Show SMILES COC(=O)c1cccc2n(cc(C(=O)CCCCCCn3c(C)nc4cnccc34)c12)C(=O)N(C)C
Show InChI InChI=1S/C27H31N5O4/c1-18-29-21-16-28-14-13-22(21)31(18)15-8-6-5-7-12-24(33)20-17-32(27(35)30(2)3)23-11-9-10-19(25(20)23)26(34)36-4/h9-11,13-14,16-17H,5-8,12,15H2,1-4H3
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 9.40n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Binding potency against Platelet activating factor (PAF) receptor using [3H]-C18-PAF as radioligand on rabbit platelet membranes

J Med Chem 41: 74-95 (1998)


Article DOI: 10.1021/jm970389+
BindingDB Entry DOI: 10.7270/Q2MC8Z4D
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Cavia porcellus)		BDBM50062055
PNG
(1-Dimethylcarbamoyl-3-[3-methoxy-4-(2-methyl-imida...)
Show SMILES COC(=O)c1cccc2n(cc(C(=O)c3ccc(Cn4c(C)nc5cnccc45)c(OC)c3)c12)C(=O)N(C)C
Show InChI InChI=1S/C29H27N5O5/c1-17-31-22-14-30-12-11-23(22)33(17)15-19-10-9-18(13-25(19)38-4)27(35)21-16-34(29(37)32(2)3)24-8-6-7-20(26(21)24)28(36)39-5/h6-14,16H,15H2,1-5H3
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 10n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Binding potency against Platelet activating factor (PAF) receptor using [3H]-C18-PAF as radioligand on rabbit platelet membranes

J Med Chem 41: 74-95 (1998)


Article DOI: 10.1021/jm970389+
BindingDB Entry DOI: 10.7270/Q2MC8Z4D
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Cavia porcellus)		BDBM50062070
PNG
(1-Dimethylcarbamoyl-3-[4-(2-methyl-imidazo[4,5-b]p...)
Show SMILES COC(=O)c1cccc2n(cc(C(=O)c3ccc(Cn4c(C)nc5cccnc45)cc3)c12)C(=O)N(C)C
Show InChI InChI=1S/C28H25N5O4/c1-17-30-22-8-6-14-29-26(22)32(17)15-18-10-12-19(13-11-18)25(34)21-16-33(28(36)31(2)3)23-9-5-7-20(24(21)23)27(35)37-4/h5-14,16H,15H2,1-4H3
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 10n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Binding potency against Platelet activating factor (PAF) receptor using [3H]-C18-PAF as radioligand on rabbit platelet membranes

J Med Chem 41: 74-95 (1998)


Article DOI: 10.1021/jm970389+
BindingDB Entry DOI: 10.7270/Q2MC8Z4D
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Cavia porcellus)		BDBM50062087
PNG
(1-Dimethylcarbamoyl-3-[5-(2-methyl-imidazo[4,5-c]p...)
Show SMILES COC(=O)c1cccc2n(cc(C(=O)CCCCn3c(C)nc4cnccc34)c12)C(=O)N(C)C
Show InChI InChI=1S/C25H27N5O4/c1-16-27-19-14-26-12-11-20(19)29(16)13-6-5-10-22(31)18-15-30(25(33)28(2)3)21-9-7-8-17(23(18)21)24(32)34-4/h7-9,11-12,14-15H,5-6,10,13H2,1-4H3
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 11n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Binding potency against Platelet activating factor (PAF) receptor using [3H]-C18-PAF as radioligand on rabbit platelet membranes

J Med Chem 41: 74-95 (1998)


Article DOI: 10.1021/jm970389+
BindingDB Entry DOI: 10.7270/Q2MC8Z4D
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Cavia porcellus)		BDBM50062116
PNG
(4-Bromo-3-[4-(2-methyl-imidazo[4,5-c]pyridin-1-ylm...)
Show SMILES CN(C)C(=O)n1cc(C(=O)c2ccc(Cn3c(C)nc4cnccc34)cc2)c2c(Br)cccc12
Show InChI InChI=1S/C26H22BrN5O2/c1-16-29-21-13-28-12-11-22(21)31(16)14-17-7-9-18(10-8-17)25(33)19-15-32(26(34)30(2)3)23-6-4-5-20(27)24(19)23/h4-13,15H,14H2,1-3H3
MMDB

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 11n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Binding potency against Platelet activating factor (PAF) receptor using [3H]-C18-PAF as radioligand on rabbit platelet membranes

J Med Chem 41: 74-95 (1998)


Article DOI: 10.1021/jm970389+
BindingDB Entry DOI: 10.7270/Q2MC8Z4D
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Cavia porcellus)		BDBM50062073
PNG
(4-Furan-2-yl-3-[4-(2-methyl-imidazo[4,5-c]pyridin-...)
Show SMILES CN(C)C(=O)n1cc(C(=O)c2ccc(Cn3c(C)nc4cnccc34)cc2)c2c(cccc12)-c1ccco1
Show InChI InChI=1S/C30H25N5O3/c1-19-32-24-16-31-14-13-25(24)34(19)17-20-9-11-21(12-10-20)29(36)23-18-35(30(37)33(2)3)26-7-4-6-22(28(23)26)27-8-5-15-38-27/h4-16,18H,17H2,1-3H3
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 11n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Binding potency against Platelet activating factor (PAF) receptor using [3H]-C18-PAF as radioligand on rabbit platelet membranes

J Med Chem 41: 74-95 (1998)


Article DOI: 10.1021/jm970389+
BindingDB Entry DOI: 10.7270/Q2MC8Z4D
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Cavia porcellus)		BDBM50062057
PNG
(3-[4-(2-Methyl-imidazo[4,5-c]pyridin-1-ylmethyl)-b...)
Show SMILES COC(=O)c1cccc2n(cc(C(=O)c3ccc(Cn4c(C)nc5cnccc45)cc3)c12)C(=O)N1CCCC1
Show InChI InChI=1S/C30H27N5O4/c1-19-32-24-16-31-13-12-25(24)34(19)17-20-8-10-21(11-9-20)28(36)23-18-35(30(38)33-14-3-4-15-33)26-7-5-6-22(27(23)26)29(37)39-2/h5-13,16,18H,3-4,14-15,17H2,1-2H3
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 11n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Binding potency against Platelet activating factor (PAF) receptor using [3H]-C18-PAF as radioligand on rabbit platelet membranes

J Med Chem 41: 74-95 (1998)


Article DOI: 10.1021/jm970389+
BindingDB Entry DOI: 10.7270/Q2MC8Z4D
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Cavia porcellus)		BDBM50062122
PNG
(3-[4-(2-Methyl-imidazo[4,5-c]pyridin-1-ylmethyl)-b...)
Show SMILES CN(C)C(=O)c1cccc2n(cc(C(=O)c3ccc(Cn4c(C)nc5cnccc45)cc3)c12)C(=O)N(C)C
Show InChI InChI=1S/C29H28N6O3/c1-18-31-23-15-30-14-13-24(23)34(18)16-19-9-11-20(12-10-19)27(36)22-17-35(29(38)33(4)5)25-8-6-7-21(26(22)25)28(37)32(2)3/h6-15,17H,16H2,1-5H3
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 11n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Binding potency against Platelet activating factor (PAF) receptor using [3H]-C18-PAF as radioligand on rabbit platelet membranes

J Med Chem 41: 74-95 (1998)


Article DOI: 10.1021/jm970389+
BindingDB Entry DOI: 10.7270/Q2MC8Z4D
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Cavia porcellus)		BDBM50062117
PNG
((7-Benzyloxy-1H-indol-3-yl)-[4-(2-methyl-imidazo[4...)
Show SMILES Cc1nc2cnccc2n1Cc1ccc(cc1)C(=O)c1c[nH]c2c(OCc3ccccc3)cccc12
Show InChI InChI=1S/C30H24N4O2/c1-20-33-26-17-31-15-14-27(26)34(20)18-21-10-12-23(13-11-21)30(35)25-16-32-29-24(25)8-5-9-28(29)36-19-22-6-3-2-4-7-22/h2-17,32H,18-19H2,1H3
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 12n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Binding potency against Platelet activating factor (PAF) receptor using [3H]-C18-PAF as radioligand on rabbit platelet membranes

J Med Chem 41: 74-95 (1998)


Article DOI: 10.1021/jm970389+
BindingDB Entry DOI: 10.7270/Q2MC8Z4D
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Cavia porcellus)		BDBM50062078
PNG
(3-[4-(2-Methyl-imidazo[4,5-c]pyridin-1-ylmethyl)-b...)
Show SMILES CN(C)C(=O)n1cc(c2ccccc12)S(=O)(=O)c1ccc(Cn2c(C)nc3cnccc23)cc1
Show InChI InChI=1S/C25H23N5O3S/c1-17-27-21-14-26-13-12-23(21)29(17)15-18-8-10-19(11-9-18)34(32,33)24-16-30(25(31)28(2)3)22-7-5-4-6-20(22)24/h4-14,16H,15H2,1-3H3
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 12n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Binding potency against Platelet activating factor (PAF) receptor using [3H]-C18-PAF as radioligand on rabbit platelet membranes

J Med Chem 41: 74-95 (1998)


Article DOI: 10.1021/jm970389+
BindingDB Entry DOI: 10.7270/Q2MC8Z4D
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Cavia porcellus)		BDBM50062120
PNG
(1-Dimethylcarbamoyl-3-[4-(2-methyl-imidazo[4,5-c]p...)
Show SMILES COC(=O)c1cccc2n(cc(c12)S(=O)(=O)c1ccc(Cn2c(C)nc3cnccc23)cc1)C(=O)N(C)C
Show InChI InChI=1S/C27H25N5O5S/c1-17-29-21-14-28-13-12-22(21)31(17)15-18-8-10-19(11-9-18)38(35,36)24-16-32(27(34)30(2)3)23-7-5-6-20(25(23)24)26(33)37-4/h5-14,16H,15H2,1-4H3
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 13n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Binding potency against Platelet activating factor (PAF) receptor using [3H]-C18-PAF as radioligand on rabbit platelet membranes

J Med Chem 41: 74-95 (1998)


Article DOI: 10.1021/jm970389+
BindingDB Entry DOI: 10.7270/Q2MC8Z4D
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Cavia porcellus)		BDBM50062046
PNG
(1-Dimethylcarbamoyl-3-[4-(2-methyl-imidazo[4,5-c]p...)
Show SMILES CN(C)C(=O)n1cc(C(=O)c2ccc(Cn3c(C)nc4cnccc34)cc2)c2c(cccc12)C(O)=O
Show InChI InChI=1S/C27H23N5O4/c1-16-29-21-13-28-12-11-22(21)31(16)14-17-7-9-18(10-8-17)25(33)20-15-32(27(36)30(2)3)23-6-4-5-19(24(20)23)26(34)35/h4-13,15H,14H2,1-3H3,(H,34,35)
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 14n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Binding potency against Platelet activating factor (PAF) receptor using [3H]-C18-PAF as radioligand on rabbit platelet membranes

J Med Chem 41: 74-95 (1998)


Article DOI: 10.1021/jm970389+
BindingDB Entry DOI: 10.7270/Q2MC8Z4D
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Cavia porcellus)		BDBM50062105
PNG
(1-[4-Chloro-1-(2-ethoxy-ethyl)-1H-indol-3-yl]-2-[4...)
Show SMILES CCOCCn1cc(C(=O)CN2CCC(CC2)n2c(C)nc3cnccc23)c2c(Cl)cccc12
Show InChI InChI=1S/C26H30ClN5O2/c1-3-34-14-13-31-16-20(26-21(27)5-4-6-24(26)31)25(33)17-30-11-8-19(9-12-30)32-18(2)29-22-15-28-10-7-23(22)32/h4-7,10,15-16,19H,3,8-9,11-14,17H2,1-2H3
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 15n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Binding potency against Platelet activating factor (PAF) receptor using [3H]-C18-PAF as radioligand on rabbit platelet membranes

J Med Chem 41: 74-95 (1998)


Article DOI: 10.1021/jm970389+
BindingDB Entry DOI: 10.7270/Q2MC8Z4D
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Cavia porcellus)		BDBM50062050
PNG
(1-Dimethylcarbamoyl-3-[4-(2-methyl-imidazo[4,5-c]p...)
Show SMILES COC(=O)c1cccc2n(cc(C(=O)c3ccc(Cn4c(C)nc5ccncc45)cc3)c12)C(=O)N(C)C
Show InChI InChI=1S/C28H25N5O4/c1-17-30-22-12-13-29-14-24(22)32(17)15-18-8-10-19(11-9-18)26(34)21-16-33(28(36)31(2)3)23-7-5-6-20(25(21)23)27(35)37-4/h5-14,16H,15H2,1-4H3
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 16n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Binding potency against Platelet activating factor (PAF) receptor using [3H]-C18-PAF as radioligand on rabbit platelet membranes

J Med Chem 41: 74-95 (1998)


Article DOI: 10.1021/jm970389+
BindingDB Entry DOI: 10.7270/Q2MC8Z4D
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Cavia porcellus)		BDBM50062044
PNG
(4-Ethynyl-3-[3-fluoro-4-(2-methyl-5-oxy-imidazo[4,...)
Show SMILES CN(C)C(=O)n1cc(C(=O)c2ccc(Cn3c(C)nc4c[n+]([O-])ccc34)c(F)c2)c2c(cccc12)C#C
Show InChI InChI=1S/C28H22FN5O3/c1-5-18-7-6-8-25-26(18)21(15-34(25)28(36)31(3)4)27(35)19-9-10-20(22(29)13-19)14-33-17(2)30-23-16-32(37)12-11-24(23)33/h1,6-13,15-16H,14H2,2-4H3
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 19n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Binding potency against Platelet activating factor (PAF) receptor using [3H]-C18-PAF as radioligand on rabbit platelet membranes

J Med Chem 41: 74-95 (1998)


Article DOI: 10.1021/jm970389+
BindingDB Entry DOI: 10.7270/Q2MC8Z4D
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Cavia porcellus)		BDBM50062094
PNG
(1-Dimethylcarbamoyl-3-{2-[4-(2-methyl-imidazo[4,5-...)
Show SMILES COC(=O)c1cccc2n(cc(C(=O)CN3CCC(CC3)n3c(C)nc4cnccc34)c12)C(=O)N(C)C
Show InChI InChI=1S/C27H30N6O4/c1-17-29-21-14-28-11-8-22(21)33(17)18-9-12-31(13-10-18)16-24(34)20-15-32(27(36)30(2)3)23-7-5-6-19(25(20)23)26(35)37-4/h5-8,11,14-15,18H,9-10,12-13,16H2,1-4H3
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 19n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Binding potency against Platelet activating factor (PAF) receptor using [3H]-C18-PAF as radioligand on rabbit platelet membranes

J Med Chem 41: 74-95 (1998)


Article DOI: 10.1021/jm970389+
BindingDB Entry DOI: 10.7270/Q2MC8Z4D
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Cavia porcellus)		BDBM50062088
PNG
(1-Dimethylcarbamoyl-3-[4-(2-methyl-5-oxy-imidazo[4...)
Show SMILES COC(=O)c1cccc2n(cc(C(=O)c3ccc(Cn4c(C)nc5c[n+]([O-])ccc45)cc3)c12)C(=O)N(C)C
Show InChI InChI=1S/C28H25N5O5/c1-17-29-22-16-31(37)13-12-23(22)32(17)14-18-8-10-19(11-9-18)26(34)21-15-33(28(36)30(2)3)24-7-5-6-20(25(21)24)27(35)38-4/h5-13,15-16H,14H2,1-4H3
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 23n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Binding potency against Platelet activating factor (PAF) receptor using [3H]-C18-PAF as radioligand on rabbit platelet membranes

J Med Chem 41: 74-95 (1998)


Article DOI: 10.1021/jm970389+
BindingDB Entry DOI: 10.7270/Q2MC8Z4D
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Cavia porcellus)		BDBM50062068
PNG
(CHEMBL174618 | Dimethyl-carbamic acid 1-dimethylca...)
Show SMILES CN(C)C(=O)Oc1cccc2n(cc(C(=O)c3ccc(Cn4c(C)nc5cnccc45)c(F)c3)c12)C(=O)N(C)C
Show InChI InChI=1S/C29H27FN6O4/c1-17-32-22-14-31-12-11-23(22)35(17)15-19-10-9-18(13-21(19)30)27(37)20-16-36(28(38)33(2)3)24-7-6-8-25(26(20)24)40-29(39)34(4)5/h6-14,16H,15H2,1-5H3
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 31n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Binding potency against Platelet activating factor (PAF) receptor using [3H]-C18-PAF as radioligand on rabbit platelet membranes

J Med Chem 41: 74-95 (1998)


Article DOI: 10.1021/jm970389+
BindingDB Entry DOI: 10.7270/Q2MC8Z4D
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Cavia porcellus)		BDBM50062083
PNG
(6-(4-Fluoro-phenyl)-3-[4-(2-methyl-imidazo[4,5-c]p...)
Show SMILES CN(C)C(=O)n1cc(C(=O)c2nc(Cn3c(C)nc4cnccc34)cs2)c2ccc(cc12)-c1ccc(F)cc1
Show InChI InChI=1S/C29H23FN6O2S/c1-17-32-24-13-31-11-10-25(24)35(17)14-21-16-39-28(33-21)27(37)23-15-36(29(38)34(2)3)26-12-19(6-9-22(23)26)18-4-7-20(30)8-5-18/h4-13,15-16H,14H2,1-3H3
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 39n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Binding potency against Platelet activating factor (PAF) receptor using [3H]-C18-PAF as radioligand on rabbit platelet membranes

J Med Chem 41: 74-95 (1998)


Article DOI: 10.1021/jm970389+
BindingDB Entry DOI: 10.7270/Q2MC8Z4D
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Cavia porcellus)		BDBM50062076
PNG
(6-(4-Fluoro-phenyl)-3-{4-[2-(2-methyl-imidazo[4,5-...)
Show SMILES CN(C)C(=O)n1cc(C(=O)N2CCN(CCn3c(C)nc4cnccc34)CC2)c2ccc(cc12)-c1ccc(F)cc1
Show InChI InChI=1S/C31H32FN7O2/c1-21-34-27-19-33-11-10-28(27)38(21)17-14-36-12-15-37(16-13-36)30(40)26-20-39(31(41)35(2)3)29-18-23(6-9-25(26)29)22-4-7-24(32)8-5-22/h4-11,18-20H,12-17H2,1-3H3
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 39n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Binding potency against Platelet activating factor (PAF) receptor using [3H]-C18-PAF as radioligand on rabbit platelet membranes

J Med Chem 41: 74-95 (1998)


Article DOI: 10.1021/jm970389+
BindingDB Entry DOI: 10.7270/Q2MC8Z4D
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Cavia porcellus)		BDBM50062079
PNG
(CHEMBL352872 | [4-(2-Methyl-imidazo[4,5-c]pyridin-...)
Show SMILES Cc1[nH]c2ccccc2c1C(=O)c1ccc(Cn2c(C)nc3cnccc23)cc1
Show InChI InChI=1S/C24H20N4O/c1-15-23(19-5-3-4-6-20(19)26-15)24(29)18-9-7-17(8-10-18)14-28-16(2)27-21-13-25-12-11-22(21)28/h3-13,26H,14H2,1-2H3
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 48n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Binding potency against Platelet activating factor (PAF) receptor using [3H]-C18-PAF as radioligand on rabbit platelet membranes

J Med Chem 41: 74-95 (1998)


Article DOI: 10.1021/jm970389+
BindingDB Entry DOI: 10.7270/Q2MC8Z4D
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Cavia porcellus)		BDBM50062040
PNG
(4-Cyano-3-[4-(2-methyl-imidazo[4,5-c]pyridin-1-ylm...)
Show SMILES CN(C)C(=O)n1cc(C(=O)c2ccc(Cn3c(C)nc4cnccc34)cc2)c2c(cccc12)C#N
Show InChI InChI=1S/C27H22N6O2/c1-17-30-22-14-29-12-11-23(22)32(17)15-18-7-9-19(10-8-18)26(34)21-16-33(27(35)31(2)3)24-6-4-5-20(13-28)25(21)24/h4-12,14,16H,15H2,1-3H3
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 51n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Binding potency against Platelet activating factor (PAF) receptor using [3H]-C18-PAF as radioligand on rabbit platelet membranes

J Med Chem 41: 74-95 (1998)


Article DOI: 10.1021/jm970389+
BindingDB Entry DOI: 10.7270/Q2MC8Z4D
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Cavia porcellus)		BDBM50062053
PNG
(6-(4-Fluoro-phenyl)-3-{4-[2-(2-methyl-imidazo[4,5-...)
Show SMILES CN(C)C(=O)n1cc(c2ccc(cc12)-c1ccc(F)cc1)S(=O)(=O)N1CCN(CCn2c(C)nc3cnccc23)CC1
Show InChI InChI=1S/C30H32FN7O3S/c1-21-33-26-19-32-11-10-27(26)37(21)17-14-35-12-15-36(16-13-35)42(40,41)29-20-38(30(39)34(2)3)28-18-23(6-9-25(28)29)22-4-7-24(31)8-5-22/h4-11,18-20H,12-17H2,1-3H3
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 53n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Binding potency against Platelet activating factor (PAF) receptor using [3H]-C18-PAF as radioligand on rabbit platelet membranes

J Med Chem 41: 74-95 (1998)


Article DOI: 10.1021/jm970389+
BindingDB Entry DOI: 10.7270/Q2MC8Z4D
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Cavia porcellus)		BDBM50062103
PNG
(CHEMBL174454 | [6-(4-Fluoro-phenyl)-1H-indol-3-yl]...)
Show SMILES Cc1nc2cnccc2n1Cc1ccc(cc1)C(=O)c1c[nH]c2cc(ccc12)-c1ccc(F)cc1
Show InChI InChI=1S/C29H21FN4O/c1-18-33-27-16-31-13-12-28(27)34(18)17-19-2-4-21(5-3-19)29(35)25-15-32-26-14-22(8-11-24(25)26)20-6-9-23(30)10-7-20/h2-16,32H,17H2,1H3
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 75n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Binding potency against Platelet activating factor (PAF) receptor using [3H]-C18-PAF as radioligand on rabbit platelet membranes

J Med Chem 41: 74-95 (1998)


Article DOI: 10.1021/jm970389+
BindingDB Entry DOI: 10.7270/Q2MC8Z4D
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Cavia porcellus)		BDBM50062085
PNG
(1-Dimethylcarbamoyl-3-[4-(2-methyl-imidazo[4,5-c]p...)
Show SMILES COC(=O)c1ccc2n(cc(C(=O)c3ccc(Cn4c(C)nc5cnccc45)cc3)c2c1)C(=O)N(C)C
Show InChI InChI=1S/C28H25N5O4/c1-17-30-23-14-29-12-11-25(23)32(17)15-18-5-7-19(8-6-18)26(34)22-16-33(28(36)31(2)3)24-10-9-20(13-21(22)24)27(35)37-4/h5-14,16H,15H2,1-4H3
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 110n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Binding potency against Platelet activating factor (PAF) receptor using [3H]-C18-PAF as radioligand on rabbit platelet membranes

J Med Chem 41: 74-95 (1998)


Article DOI: 10.1021/jm970389+
BindingDB Entry DOI: 10.7270/Q2MC8Z4D
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Cavia porcellus)		BDBM50062043
PNG
(6-(4-Fluoro-phenyl)-3-[4-(2-methyl-imidazo[4,5-c]p...)
Show SMILES CN(C)C(=O)n1cc(c2ccc(cc12)-c1ccc(F)cc1)S(=O)(=O)N1CCN(CC1)n1c(C)nc2cnccc12
Show InChI InChI=1S/C28H28FN7O3S/c1-19-31-24-17-30-11-10-25(24)36(19)33-12-14-34(15-13-33)40(38,39)27-18-35(28(37)32(2)3)26-16-21(6-9-23(26)27)20-4-7-22(29)8-5-20/h4-11,16-18H,12-15H2,1-3H3
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 120n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Binding potency against Platelet activating factor (PAF) receptor using [3H]-C18-PAF as radioligand on rabbit platelet membranes

J Med Chem 41: 74-95 (1998)


Article DOI: 10.1021/jm970389+
BindingDB Entry DOI: 10.7270/Q2MC8Z4D
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Cavia porcellus)		BDBM50062111
PNG
(1-Dimethylcarbamoyl-3-[4-(2,4,6-trimethyl-imidazo[...)
Show SMILES COC(=O)c1cccc2n(cc(C(=O)c3ccc(Cn4c(C)nc5c(C)nc(C)cc45)cc3)c12)C(=O)N(C)C
Show InChI InChI=1S/C30H29N5O4/c1-17-14-25-27(18(2)31-17)32-19(3)34(25)15-20-10-12-21(13-11-20)28(36)23-16-35(30(38)33(4)5)24-9-7-8-22(26(23)24)29(37)39-6/h7-14,16H,15H2,1-6H3
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 120n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Binding potency against Platelet activating factor (PAF) receptor using [3H]-C18-PAF as radioligand on rabbit platelet membranes

J Med Chem 41: 74-95 (1998)


Article DOI: 10.1021/jm970389+
BindingDB Entry DOI: 10.7270/Q2MC8Z4D
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Cavia porcellus)		BDBM50062097
PNG
(6-(4-Fluoro-phenyl)-3-(2-{methyl-[3-(2-methyl-imid...)
Show SMILES CN(CCCn1c(C)nc2cnccc12)CC(=O)c1cn(C(=O)N(C)C)c2cc(ccc12)-c1ccc(F)cc1
Show InChI InChI=1S/C30H31FN6O2/c1-20-33-26-17-32-13-12-27(26)36(20)15-5-14-35(4)19-29(38)25-18-37(30(39)34(2)3)28-16-22(8-11-24(25)28)21-6-9-23(31)10-7-21/h6-13,16-18H,5,14-15,19H2,1-4H3
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 140n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Binding potency against Platelet activating factor (PAF) receptor using [3H]-C18-PAF as radioligand on rabbit platelet membranes

J Med Chem 41: 74-95 (1998)


Article DOI: 10.1021/jm970389+
BindingDB Entry DOI: 10.7270/Q2MC8Z4D
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Cavia porcellus)		BDBM50062123
PNG
(6-(4-Fluoro-phenyl)-3-[3-(2-methyl-imidazo[4,5-c]p...)
Show SMILES CN(C)C(=O)n1cc(C(=O)c2cccc(Cn3c(C)nc4cnccc34)c2)c2ccc(cc12)-c1ccc(F)cc1
Show InChI InChI=1S/C32H26FN5O2/c1-20-35-28-17-34-14-13-29(28)37(20)18-21-5-4-6-24(15-21)31(39)27-19-38(32(40)36(2)3)30-16-23(9-12-26(27)30)22-7-10-25(33)11-8-22/h4-17,19H,18H2,1-3H3
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 180n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Binding potency against Platelet activating factor (PAF) receptor using [3H]-C18-PAF as radioligand on rabbit platelet membranes

J Med Chem 41: 74-95 (1998)


Article DOI: 10.1021/jm970389+
BindingDB Entry DOI: 10.7270/Q2MC8Z4D
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Cavia porcellus)		BDBM50062096
PNG
(5-(4-Fluoro-phenyl)-3-[4-(2-methyl-imidazo[4,5-c]p...)
Show SMILES CN(C)C(=O)n1cc(C(=O)c2ccc(Cn3c(C)nc4cnccc34)cc2)c2cc(ccc12)-c1ccc(F)cc1
Show InChI InChI=1S/C32H26FN5O2/c1-20-35-28-17-34-15-14-30(28)37(20)18-21-4-6-23(7-5-21)31(39)27-19-38(32(40)36(2)3)29-13-10-24(16-26(27)29)22-8-11-25(33)12-9-22/h4-17,19H,18H2,1-3H3
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 190n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Binding potency against Platelet activating factor (PAF) receptor using [3H]-C18-PAF as radioligand on rabbit platelet membranes

J Med Chem 41: 74-95 (1998)


Article DOI: 10.1021/jm970389+
BindingDB Entry DOI: 10.7270/Q2MC8Z4D
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Cavia porcellus)		BDBM50062100
PNG
(6-(4-Fluoro-phenyl)-3-[4-(2-methyl-imidazo[4,5-c]p...)
Show SMILES CN(C)C(=O)n1cc(C(=O)c2ccc(cc2)-n2c(C)nc3cnccc23)c2ccc(cc12)-c1ccc(F)cc1
Show InChI InChI=1S/C31H24FN5O2/c1-19-34-27-17-33-15-14-28(27)37(19)24-11-6-21(7-12-24)30(38)26-18-36(31(39)35(2)3)29-16-22(8-13-25(26)29)20-4-9-23(32)10-5-20/h4-18H,1-3H3
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 260n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Binding potency against Platelet activating factor (PAF) receptor using [3H]-C18-PAF as radioligand on rabbit platelet membranes

J Med Chem 41: 74-95 (1998)


Article DOI: 10.1021/jm970389+
BindingDB Entry DOI: 10.7270/Q2MC8Z4D
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Cavia porcellus)		BDBM50062089
PNG
(6-(4-Fluoro-phenyl)-3-[4-(2-methyl-imidazo[4,5-c]p...)
Show SMILES CN(C)C(=O)n1cc(C(=O)c2ccc(Cn3c(C)nc4ccncc34)cc2)c2ccc(cc12)-c1ccc(F)cc1
Show InChI InChI=1S/C32H26FN5O2/c1-20-35-28-14-15-34-17-30(28)37(20)18-21-4-6-23(7-5-21)31(39)27-19-38(32(40)36(2)3)29-16-24(10-13-26(27)29)22-8-11-25(33)12-9-22/h4-17,19H,18H2,1-3H3
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 610n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Binding potency against Platelet activating factor (PAF) receptor using [3H]-C18-PAF as radioligand on rabbit platelet membranes

J Med Chem 41: 74-95 (1998)


Article DOI: 10.1021/jm970389+
BindingDB Entry DOI: 10.7270/Q2MC8Z4D
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Cavia porcellus)		BDBM50062047
PNG
(6-(4-Fluoro-phenyl)-3-[4-(2-methyl-imidazo[4,5-c]p...)
Show SMILES CN(C)C(=O)n1cc(C(=O)c2ccc(Cn3ccc4nc(C)nc4c3)cc2)c2ccc(cc12)-c1ccc(F)cc1
Show InChI InChI=1S/C32H26FN5O2/c1-20-34-28-14-15-37(19-29(28)35-20)17-21-4-6-23(7-5-21)31(39)27-18-38(32(40)36(2)3)30-16-24(10-13-26(27)30)22-8-11-25(33)12-9-22/h4-16,18-19H,17H2,1-3H3
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>1.00E+3n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Binding potency against Platelet activating factor (PAF) receptor using [3H]-C18-PAF as radioligand on rabbit platelet membranes

J Med Chem 41: 74-95 (1998)


Article DOI: 10.1021/jm970389+
BindingDB Entry DOI: 10.7270/Q2MC8Z4D
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Cavia porcellus)		BDBM50062109
PNG
(1-Dimethylcarbamoyl-3-[4-(2-methyl-imidazo[4,5-c]p...)
Show SMILES COC(=O)c1cccc2n(cc(C(=O)c3ccc(Cn4ccc5nc(C)nc5c4)cc3)c12)C(=O)N(C)C
Show InChI InChI=1S/C28H25N5O4/c1-17-29-22-12-13-32(16-23(22)30-17)14-18-8-10-19(11-9-18)26(34)21-15-33(28(36)31(2)3)24-7-5-6-20(25(21)24)27(35)37-4/h5-13,15-16H,14H2,1-4H3
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>1.00E+3n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Binding potency against Platelet activating factor (PAF) receptor using [3H]-C18-PAF as radioligand on rabbit platelet membranes

J Med Chem 41: 74-95 (1998)


Article DOI: 10.1021/jm970389+
BindingDB Entry DOI: 10.7270/Q2MC8Z4D
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Cavia porcellus)		BDBM50062080
PNG
(6-(4-Fluoro-phenyl)-3-[2-(2-methyl-imidazo[4,5-c]p...)
Show SMILES CN(C)C(=O)n1cc(C(=O)Cn2c(C)nc3cnccc23)c2ccc(cc12)-c1ccc(F)cc1
Show InChI InChI=1S/C26H22FN5O2/c1-16-29-22-13-28-11-10-23(22)31(16)15-25(33)21-14-32(26(34)30(2)3)24-12-18(6-9-20(21)24)17-4-7-19(27)8-5-17/h4-14H,15H2,1-3H3
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>1.00E+3n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Binding potency against Platelet activating factor (PAF) receptor using [3H]-C18-PAF as radioligand on rabbit platelet membranes

J Med Chem 41: 74-95 (1998)


Article DOI: 10.1021/jm970389+
BindingDB Entry DOI: 10.7270/Q2MC8Z4D
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%