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PubMed code 9572880

Compile data set for download or QSAR
Found 44 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Sigma non-opioid intracellular receptor 1


(Homo sapiens (Human))		BDBM50064172
PNG
(1-benzylspiro[hexahydropyridine-4,2'-(3',4'-dihydr...)
Show SMILES C(N1CCC2(CC1)CCc1ccccc1S2)c1ccccc1
Show InChI InChI=1S/C20H23NS/c1-2-6-17(7-3-1)16-21-14-12-20(13-15-21)11-10-18-8-4-5-9-19(18)22-20/h1-9H,10-16H2
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 0.5n/an/an/an/an/an/an/an/a



University of Camerino

Curated by ChEMBL


Assay Description
Compound was tested for its binding affinity towards sigma 1 receptor using [3H]-(+)-pentazocine from guinea pig brain

J Med Chem 41: 1557-60 (1998)


Article DOI: 10.1021/jm970740r
BindingDB Entry DOI: 10.7270/Q2N29W3Q
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Homo sapiens (Human))		BDBM50064171
PNG
(1'-benzylspiro[3,4-dihydro-2H-chromene-2,4'-(hexah...)
Show SMILES C(N1CCC2(CC1)CCc1ccccc1O2)c1ccccc1
Show InChI InChI=1S/C20H23NO/c1-2-6-17(7-3-1)16-21-14-12-20(13-15-21)11-10-18-8-4-5-9-19(18)22-20/h1-9H,10-16H2
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 0.620n/an/an/an/an/an/an/an/a



University of Camerino

Curated by ChEMBL


Assay Description
Compound was tested for its binding affinity towards sigma 1 receptor using [3H]-(+)-pentazocine from guinea pig brain

J Med Chem 41: 1557-60 (1998)


Article DOI: 10.1021/jm970740r
BindingDB Entry DOI: 10.7270/Q2N29W3Q
More data for this
Ligand-Target Pair
Alpha-1A adrenergic receptor


(Rattus norvegicus (Rat))		BDBM29568
PNG
(CHEMBL2 | PRAZOSIN | PRAZOSIN HYDROCHLORIDE | [3H]...)
Show SMILES COc1cc2nc(nc(N)c2cc1OC)N1CCN(CC1)C(=O)c1ccco1
Show InChI InChI=1S/C19H21N5O4/c1-26-15-10-12-13(11-16(15)27-2)21-19(22-17(12)20)24-7-5-23(6-8-24)18(25)14-4-3-9-28-14/h3-4,9-11H,5-8H2,1-2H3,(H2,20,21,22)
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 1.05n/an/an/an/an/an/an/an/a



University of Camerino

Curated by ChEMBL


Assay Description
Compound was tested for its binding affinity towards Alpha-1A adrenergic receptor using [3H]-prazosin from rat submaxillary gland

J Med Chem 41: 1557-60 (1998)


Article DOI: 10.1021/jm970740r
BindingDB Entry DOI: 10.7270/Q2N29W3Q
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Homo sapiens (Human))		BDBM50036764
PNG
(1'-benzylspiro[1,2,3,4-tetrahydronaphthalene-2,4'-...)
Show SMILES O=C1c2ccccc2CCC11CCN(Cc2ccccc2)CC1
Show InChI InChI=1S/C21H23NO/c23-20-19-9-5-4-8-18(19)10-11-21(20)12-14-22(15-13-21)16-17-6-2-1-3-7-17/h1-9H,10-16H2
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 1.40n/an/an/an/an/an/an/an/a



University of Camerino

Curated by ChEMBL


Assay Description
Compound was tested for its binding affinity towards sigma 1 receptor using [3H]-(+)-pentazocine from guinea pig brain

J Med Chem 41: 1557-60 (1998)


Article DOI: 10.1021/jm970740r
BindingDB Entry DOI: 10.7270/Q2N29W3Q
More data for this
Ligand-Target Pair
Alpha-1B adrenergic receptor


(Rattus norvegicus (rat))		BDBM29568
PNG
(CHEMBL2 | PRAZOSIN | PRAZOSIN HYDROCHLORIDE | [3H]...)
Show SMILES COc1cc2nc(nc(N)c2cc1OC)N1CCN(CC1)C(=O)c1ccco1
Show InChI InChI=1S/C19H21N5O4/c1-26-15-10-12-13(11-16(15)27-2)21-19(22-17(12)20)24-7-5-23(6-8-24)18(25)14-4-3-9-28-14/h3-4,9-11H,5-8H2,1-2H3,(H2,20,21,22)
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 2.93n/an/an/an/an/an/an/an/a



University of Camerino

Curated by ChEMBL


Assay Description
Compound was tested for its binding affinity towards Alpha-1B adrenergic receptor using [3H]-prazosin from rat liver

J Med Chem 41: 1557-60 (1998)


Article DOI: 10.1021/jm970740r
BindingDB Entry DOI: 10.7270/Q2N29W3Q
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Homo sapiens (Human))		BDBM21398
PNG
(4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1...)
Show SMILES OC1(CCN(CCCC(=O)c2ccc(F)cc2)CC1)c1ccc(Cl)cc1
Show InChI InChI=1S/C21H23ClFNO2/c22-18-7-5-17(6-8-18)21(26)11-14-24(15-12-21)13-1-2-20(25)16-3-9-19(23)10-4-16/h3-10,26H,1-2,11-15H2
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 3.20n/an/an/an/an/an/an/an/a



University of Camerino

Curated by ChEMBL


Assay Description
Compound was tested for its binding affinity towards sigma 1 receptor using [3H]-(+)-pentazocine from guinea pig brain

J Med Chem 41: 1557-60 (1998)


Article DOI: 10.1021/jm970740r
BindingDB Entry DOI: 10.7270/Q2N29W3Q
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM21398
PNG
(4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1...)
Show SMILES OC1(CCN(CCCC(=O)c2ccc(F)cc2)CC1)c1ccc(Cl)cc1
Show InChI InChI=1S/C21H23ClFNO2/c22-18-7-5-17(6-8-18)21(26)11-14-24(15-12-21)13-1-2-20(25)16-3-9-19(23)10-4-16/h3-10,26H,1-2,11-15H2
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 4.80n/an/an/an/an/an/an/an/a



University of Camerino

Curated by ChEMBL


Assay Description
Compound was tested for its binding affinity towards Dopamine receptor D2 using [3H]-spiperone from rat striatum

J Med Chem 41: 1557-60 (1998)


Article DOI: 10.1021/jm970740r
BindingDB Entry DOI: 10.7270/Q2N29W3Q
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Homo sapiens (Human))		BDBM50035131
PNG
((+)-(6R,11S)-6,11-dimethyl-3-(3-methyl-but-2-enyl)...)
Show SMILES [#6]-[#6@@H]1-[#6@@H]-2-[#6]-c3ccc(-[#8])cc3[C@@]1([#6])[#6]-[#6]-[#7]-2-[#6]\[#6]=[#6](/[#6])-[#6] |r,TLB:16:15:10.4.3:1|
Show InChI InChI=1S/C19H27NO/c1-13(2)7-9-20-10-8-19(4)14(3)18(20)11-15-5-6-16(21)12-17(15)19/h5-7,12,14,18,21H,8-11H2,1-4H3/t14-,18+,19+/m1/s1
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 6.10n/an/an/an/an/an/an/an/a



University of Camerino

Curated by ChEMBL


Assay Description
Compound was tested for its binding affinity towards sigma 1 receptor using [3H]-(+)-pentazocine from guinea pig brain

J Med Chem 41: 1557-60 (1998)


Article DOI: 10.1021/jm970740r
BindingDB Entry DOI: 10.7270/Q2N29W3Q
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Muscarinic acetylcholine receptor M2


(RAT)		BDBM50064176
PNG
(CHEMBL27673 | CHEMBL500996 | METHOCTRAMINE | N,N''...)
Show SMILES COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC
Show InChI InChI=1S/C36H62N4O2/c1-41-35-23-13-11-21-33(35)31-39-29-19-9-7-17-27-37-25-15-5-3-4-6-16-26-38-28-18-8-10-20-30-40-32-34-22-12-14-24-36(34)42-2/h11-14,21-24,37-40H,3-10,15-20,25-32H2,1-2H3
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 15n/an/an/an/an/an/an/an/a



University of Camerino

Curated by ChEMBL


Assay Description
Compound was tested for its binding affinity towards Muscarinic acetylcholine receptor M2 using [3H]-NMS from rat heart

J Med Chem 41: 1557-60 (1998)


Article DOI: 10.1021/jm970740r
BindingDB Entry DOI: 10.7270/Q2N29W3Q
More data for this
Ligand-Target Pair
Lysosomal Pro-X carboxypeptidase


(Homo sapiens (Human))		BDBM50044426
PNG
(1-[1-(3-Isothiocyanato-phenyl)-cyclohexyl]-piperid...)
Show SMILES S=C=Nc1cccc(c1)C1(CCCCC1)N1CCCCC1
Show InChI InChI=1S/C18H24N2S/c21-15-19-17-9-7-8-16(14-17)18(10-3-1-4-11-18)20-12-5-2-6-13-20/h7-9,14H,1-6,10-13H2
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 16n/an/an/an/an/an/an/an/a



University of Camerino

Curated by ChEMBL


Assay Description
Compound was tested for its binding affinity towards PCP receptor using [3H]-(+)-NANM in the presence of 5 microM haloperidol from rat brain

J Med Chem 41: 1557-60 (1998)


Article DOI: 10.1021/jm970740r
BindingDB Entry DOI: 10.7270/Q2N29W3Q
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Homo sapiens (Human))		BDBM50064173
PNG
(1-benzylspiro[hexahydropyridine-4,2'-(3',4'-dihydr...)
Show SMILES O=S1(=O)c2ccccc2CCC11CCN(Cc2ccccc2)CC1
Show InChI InChI=1S/C20H23NO2S/c22-24(23)19-9-5-4-8-18(19)10-11-20(24)12-14-21(15-13-20)16-17-6-2-1-3-7-17/h1-9H,10-16H2
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 20n/an/an/an/an/an/an/an/a



University of Camerino

Curated by ChEMBL


Assay Description
Compound was tested for its binding affinity towards sigma 1 receptor using [3H]-(+)-pentazocine from guinea pig brain

J Med Chem 41: 1557-60 (1998)


Article DOI: 10.1021/jm970740r
BindingDB Entry DOI: 10.7270/Q2N29W3Q
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Homo sapiens (Human))		BDBM50064175
PNG
(1-benzylspiro[hexahydropyridine-4,2'-(3',4'-dihydr...)
Show SMILES O=S1c2ccccc2CCC11CCN(Cc2ccccc2)CC1
Show InChI InChI=1S/C20H23NOS/c22-23-19-9-5-4-8-18(19)10-11-20(23)12-14-21(15-13-20)16-17-6-2-1-3-7-17/h1-9H,10-16H2
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 25n/an/an/an/an/an/an/an/a



University of Camerino

Curated by ChEMBL


Assay Description
Compound was tested for its binding affinity towards sigma 1 receptor using [3H]-(+)-pentazocine from guinea pig brain

J Med Chem 41: 1557-60 (1998)


Article DOI: 10.1021/jm970740r
BindingDB Entry DOI: 10.7270/Q2N29W3Q
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(RAT)		BDBM50064176
PNG
(CHEMBL27673 | CHEMBL500996 | METHOCTRAMINE | N,N''...)
Show SMILES COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC
Show InChI InChI=1S/C36H62N4O2/c1-41-35-23-13-11-21-33(35)31-39-29-19-9-7-17-27-37-25-15-5-3-4-6-16-26-38-28-18-8-10-20-30-40-32-34-22-12-14-24-36(34)42-2/h11-14,21-24,37-40H,3-10,15-20,25-32H2,1-2H3
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 998n/an/an/an/an/an/an/an/a



University of Camerino

Curated by ChEMBL


Assay Description
Compound was tested for its binding affinity towards Muscarinic acetylcholine receptor M3 using [3H]-NMS from rat submaxillary gland

J Med Chem 41: 1557-60 (1998)


Article DOI: 10.1021/jm970740r
BindingDB Entry DOI: 10.7270/Q2N29W3Q
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(RAT)		BDBM50036764
PNG
(1'-benzylspiro[1,2,3,4-tetrahydronaphthalene-2,4'-...)
Show SMILES O=C1c2ccccc2CCC11CCN(Cc2ccccc2)CC1
Show InChI InChI=1S/C21H23NO/c23-20-19-9-5-4-8-18(19)10-11-21(20)12-14-22(15-13-21)16-17-6-2-1-3-7-17/h1-9H,10-16H2
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 2.70E+3n/an/an/an/an/an/an/an/a



University of Camerino

Curated by ChEMBL


Assay Description
Compound was tested for its binding affinity towards Muscarinic acetylcholine receptor M2 using [3H]-NMS from rat heart

J Med Chem 41: 1557-60 (1998)


Article DOI: 10.1021/jm970740r
BindingDB Entry DOI: 10.7270/Q2N29W3Q
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50036764
PNG
(1'-benzylspiro[1,2,3,4-tetrahydronaphthalene-2,4'-...)
Show SMILES O=C1c2ccccc2CCC11CCN(Cc2ccccc2)CC1
Show InChI InChI=1S/C21H23NO/c23-20-19-9-5-4-8-18(19)10-11-21(20)12-14-22(15-13-21)16-17-6-2-1-3-7-17/h1-9H,10-16H2
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 5.50E+3n/an/an/an/an/an/an/an/a



University of Camerino

Curated by ChEMBL


Assay Description
Compound was tested for its binding affinity towards Dopamine receptor D2 using [3H]-spiperone from rat striatum

J Med Chem 41: 1557-60 (1998)


Article DOI: 10.1021/jm970740r
BindingDB Entry DOI: 10.7270/Q2N29W3Q
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Homo sapiens (Human))		BDBM50001884
PNG
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
Show SMILES CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2ccccc12 |t:8|
Show InChI InChI=1S/C18H19ClN4/c1-22-8-10-23(11-9-22)18-14-4-2-3-5-15(14)20-16-7-6-13(19)12-17(16)21-18/h2-7,12,20H,8-11H2,1H3
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 8.50E+3n/an/an/an/an/an/an/an/a



University of Camerino

Curated by ChEMBL


Assay Description
Compound was tested for its binding affinity towards sigma 1 receptor using [3H]-(+)-pentazocine from guinea pig brain

J Med Chem 41: 1557-60 (1998)


Article DOI: 10.1021/jm970740r
BindingDB Entry DOI: 10.7270/Q2N29W3Q
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2C


(Rattus norvegicus (Rat))		BDBM50064171
PNG
(1'-benzylspiro[3,4-dihydro-2H-chromene-2,4'-(hexah...)
Show SMILES C(N1CCC2(CC1)CCc1ccccc1O2)c1ccccc1
Show InChI InChI=1S/C20H23NO/c1-2-6-17(7-3-1)16-21-14-12-20(13-15-21)11-10-18-8-4-5-9-19(18)22-20/h1-9H,10-16H2
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>1.00E+4n/an/an/an/an/an/an/an/a



University of Camerino

Curated by ChEMBL


Assay Description
Compound was tested for its binding affinity towards PCP receptor using [3H]-(+)-NANM in the presence of 5 microM haloperidol from rat brain

J Med Chem 41: 1557-60 (1998)


Article DOI: 10.1021/jm970740r
BindingDB Entry DOI: 10.7270/Q2N29W3Q
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50064171
PNG
(1'-benzylspiro[3,4-dihydro-2H-chromene-2,4'-(hexah...)
Show SMILES C(N1CCC2(CC1)CCc1ccccc1O2)c1ccccc1
Show InChI InChI=1S/C20H23NO/c1-2-6-17(7-3-1)16-21-14-12-20(13-15-21)11-10-18-8-4-5-9-19(18)22-20/h1-9H,10-16H2
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>1.00E+4n/an/an/an/an/an/an/an/a



University of Camerino

Curated by ChEMBL


Assay Description
Compound was tested for its binding affinity towards Dopamine receptor D2 using [3H]-spiperone from rat striatum

J Med Chem 41: 1557-60 (1998)


Article DOI: 10.1021/jm970740r
BindingDB Entry DOI: 10.7270/Q2N29W3Q
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(RAT)		BDBM50064172
PNG
(1-benzylspiro[hexahydropyridine-4,2'-(3',4'-dihydr...)
Show SMILES C(N1CCC2(CC1)CCc1ccccc1S2)c1ccccc1
Show InChI InChI=1S/C20H23NS/c1-2-6-17(7-3-1)16-21-14-12-20(13-15-21)11-10-18-8-4-5-9-19(18)22-20/h1-9H,10-16H2
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>1.00E+4n/an/an/an/an/an/an/an/a



University of Camerino

Curated by ChEMBL


Assay Description
Compound was tested for its binding affinity towards Muscarinic acetylcholine receptor M3 using [3H]-NMS from rat submaxillary gland

J Med Chem 41: 1557-60 (1998)


Article DOI: 10.1021/jm970740r
BindingDB Entry DOI: 10.7270/Q2N29W3Q
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(RAT)		BDBM50064173
PNG
(1-benzylspiro[hexahydropyridine-4,2'-(3',4'-dihydr...)
Show SMILES O=S1(=O)c2ccccc2CCC11CCN(Cc2ccccc2)CC1
Show InChI InChI=1S/C20H23NO2S/c22-24(23)19-9-5-4-8-18(19)10-11-20(24)12-14-21(15-13-20)16-17-6-2-1-3-7-17/h1-9H,10-16H2
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>1.00E+4n/an/an/an/an/an/an/an/a



University of Camerino

Curated by ChEMBL


Assay Description
Compound was tested for its binding affinity towards Muscarinic acetylcholine receptor M3 using [3H]-NMS from rat submaxillary gland

J Med Chem 41: 1557-60 (1998)


Article DOI: 10.1021/jm970740r
BindingDB Entry DOI: 10.7270/Q2N29W3Q
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(RAT)		BDBM50064171
PNG
(1'-benzylspiro[3,4-dihydro-2H-chromene-2,4'-(hexah...)
Show SMILES C(N1CCC2(CC1)CCc1ccccc1O2)c1ccccc1
Show InChI InChI=1S/C20H23NO/c1-2-6-17(7-3-1)16-21-14-12-20(13-15-21)11-10-18-8-4-5-9-19(18)22-20/h1-9H,10-16H2
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>1.00E+4n/an/an/an/an/an/an/an/a



University of Camerino

Curated by ChEMBL


Assay Description
Compound was tested for its binding affinity towards Muscarinic acetylcholine receptor M3 using [3H]-NMS from rat submaxillary gland

J Med Chem 41: 1557-60 (1998)


Article DOI: 10.1021/jm970740r
BindingDB Entry DOI: 10.7270/Q2N29W3Q
More data for this
Ligand-Target Pair
Alpha-1A adrenergic receptor


(Rattus norvegicus (Rat))		BDBM50064171
PNG
(1'-benzylspiro[3,4-dihydro-2H-chromene-2,4'-(hexah...)
Show SMILES C(N1CCC2(CC1)CCc1ccccc1O2)c1ccccc1
Show InChI InChI=1S/C20H23NO/c1-2-6-17(7-3-1)16-21-14-12-20(13-15-21)11-10-18-8-4-5-9-19(18)22-20/h1-9H,10-16H2
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>1.00E+4n/an/an/an/an/an/an/an/a



University of Camerino

Curated by ChEMBL


Assay Description
Compound was tested for its binding affinity towards Alpha-1A adrenergic receptor using [3H]-prazosin from rat submaxillary gland

J Med Chem 41: 1557-60 (1998)


Article DOI: 10.1021/jm970740r
BindingDB Entry DOI: 10.7270/Q2N29W3Q
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2C


(Rattus norvegicus (Rat))		BDBM50064172
PNG
(1-benzylspiro[hexahydropyridine-4,2'-(3',4'-dihydr...)
Show SMILES C(N1CCC2(CC1)CCc1ccccc1S2)c1ccccc1
Show InChI InChI=1S/C20H23NS/c1-2-6-17(7-3-1)16-21-14-12-20(13-15-21)11-10-18-8-4-5-9-19(18)22-20/h1-9H,10-16H2
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>1.00E+4n/an/an/an/an/an/an/an/a



University of Camerino

Curated by ChEMBL


Assay Description
Compound was tested for its binding affinity towards PCP receptor using [3H]-(+)-NANM in the presence of 5 microM haloperidol from rat brain

J Med Chem 41: 1557-60 (1998)


Article DOI: 10.1021/jm970740r
BindingDB Entry DOI: 10.7270/Q2N29W3Q
More data for this
Ligand-Target Pair
Alpha-1B adrenergic receptor


(Rattus norvegicus (rat))		BDBM50064172
PNG
(1-benzylspiro[hexahydropyridine-4,2'-(3',4'-dihydr...)
Show SMILES C(N1CCC2(CC1)CCc1ccccc1S2)c1ccccc1
Show InChI InChI=1S/C20H23NS/c1-2-6-17(7-3-1)16-21-14-12-20(13-15-21)11-10-18-8-4-5-9-19(18)22-20/h1-9H,10-16H2
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>1.00E+4n/an/an/an/an/an/an/an/a



University of Camerino

Curated by ChEMBL


Assay Description
Compound was tested for its binding affinity towards Alpha-1B adrenergic receptor using [3H]-prazosin from rat liver

J Med Chem 41: 1557-60 (1998)


Article DOI: 10.1021/jm970740r
BindingDB Entry DOI: 10.7270/Q2N29W3Q
More data for this
Ligand-Target Pair
Alpha-1B adrenergic receptor


(Rattus norvegicus (rat))		BDBM50064173
PNG
(1-benzylspiro[hexahydropyridine-4,2'-(3',4'-dihydr...)
Show SMILES O=S1(=O)c2ccccc2CCC11CCN(Cc2ccccc2)CC1
Show InChI InChI=1S/C20H23NO2S/c22-24(23)19-9-5-4-8-18(19)10-11-20(24)12-14-21(15-13-20)16-17-6-2-1-3-7-17/h1-9H,10-16H2
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>1.00E+4n/an/an/an/an/an/an/an/a



University of Camerino

Curated by ChEMBL


Assay Description
Compound was tested for its binding affinity towards Alpha-1B adrenergic receptor using [3H]-prazosin from rat liver

J Med Chem 41: 1557-60 (1998)


Article DOI: 10.1021/jm970740r
BindingDB Entry DOI: 10.7270/Q2N29W3Q
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50064173
PNG
(1-benzylspiro[hexahydropyridine-4,2'-(3',4'-dihydr...)
Show SMILES O=S1(=O)c2ccccc2CCC11CCN(Cc2ccccc2)CC1
Show InChI InChI=1S/C20H23NO2S/c22-24(23)19-9-5-4-8-18(19)10-11-20(24)12-14-21(15-13-20)16-17-6-2-1-3-7-17/h1-9H,10-16H2
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>1.00E+4n/an/an/an/an/an/an/an/a



University of Camerino

Curated by ChEMBL


Assay Description
Compound was tested for its binding affinity towards Dopamine receptor D2 using [3H]-spiperone from rat striatum

J Med Chem 41: 1557-60 (1998)


Article DOI: 10.1021/jm970740r
BindingDB Entry DOI: 10.7270/Q2N29W3Q
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(RAT)		BDBM50036764
PNG
(1'-benzylspiro[1,2,3,4-tetrahydronaphthalene-2,4'-...)
Show SMILES O=C1c2ccccc2CCC11CCN(Cc2ccccc2)CC1
Show InChI InChI=1S/C21H23NO/c23-20-19-9-5-4-8-18(19)10-11-21(20)12-14-22(15-13-21)16-17-6-2-1-3-7-17/h1-9H,10-16H2
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>1.00E+4n/an/an/an/an/an/an/an/a



University of Camerino

Curated by ChEMBL


Assay Description
Compound was tested for its binding affinity towards Muscarinic acetylcholine receptor M3 using [3H]-NMS from rat submaxillary gland

J Med Chem 41: 1557-60 (1998)


Article DOI: 10.1021/jm970740r
BindingDB Entry DOI: 10.7270/Q2N29W3Q
More data for this
Ligand-Target Pair
Alpha-1A adrenergic receptor


(Rattus norvegicus (Rat))		BDBM50064175
PNG
(1-benzylspiro[hexahydropyridine-4,2'-(3',4'-dihydr...)
Show SMILES O=S1c2ccccc2CCC11CCN(Cc2ccccc2)CC1
Show InChI InChI=1S/C20H23NOS/c22-23-19-9-5-4-8-18(19)10-11-20(23)12-14-21(15-13-20)16-17-6-2-1-3-7-17/h1-9H,10-16H2
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>1.00E+4n/an/an/an/an/an/an/an/a



University of Camerino

Curated by ChEMBL


Assay Description
Compound was tested for its binding affinity towards Alpha-1A adrenergic receptor using [3H]-prazosin from rat submaxillary gland

J Med Chem 41: 1557-60 (1998)


Article DOI: 10.1021/jm970740r
BindingDB Entry DOI: 10.7270/Q2N29W3Q
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2C


(Rattus norvegicus (Rat))		BDBM50064175
PNG
(1-benzylspiro[hexahydropyridine-4,2'-(3',4'-dihydr...)
Show SMILES O=S1c2ccccc2CCC11CCN(Cc2ccccc2)CC1
Show InChI InChI=1S/C20H23NOS/c22-23-19-9-5-4-8-18(19)10-11-20(23)12-14-21(15-13-20)16-17-6-2-1-3-7-17/h1-9H,10-16H2
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>1.00E+4n/an/an/an/an/an/an/an/a



University of Camerino

Curated by ChEMBL


Assay Description
Compound was tested for its binding affinity towards PCP receptor using [3H]-(+)-NANM in the presence of 5 microM haloperidol from rat brain

J Med Chem 41: 1557-60 (1998)


Article DOI: 10.1021/jm970740r
BindingDB Entry DOI: 10.7270/Q2N29W3Q
More data for this
Ligand-Target Pair
Alpha-1B adrenergic receptor


(Rattus norvegicus (rat))		BDBM50064171
PNG
(1'-benzylspiro[3,4-dihydro-2H-chromene-2,4'-(hexah...)
Show SMILES C(N1CCC2(CC1)CCc1ccccc1O2)c1ccccc1
Show InChI InChI=1S/C20H23NO/c1-2-6-17(7-3-1)16-21-14-12-20(13-15-21)11-10-18-8-4-5-9-19(18)22-20/h1-9H,10-16H2
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>1.00E+4n/an/an/an/an/an/an/an/a



University of Camerino

Curated by ChEMBL


Assay Description
Compound was tested for its binding affinity towards Alpha-1B adrenergic receptor using [3H]-prazosin from rat liver

J Med Chem 41: 1557-60 (1998)


Article DOI: 10.1021/jm970740r
BindingDB Entry DOI: 10.7270/Q2N29W3Q
More data for this
Ligand-Target Pair
Alpha-1A adrenergic receptor


(Rattus norvegicus (Rat))		BDBM50064173
PNG
(1-benzylspiro[hexahydropyridine-4,2'-(3',4'-dihydr...)
Show SMILES O=S1(=O)c2ccccc2CCC11CCN(Cc2ccccc2)CC1
Show InChI InChI=1S/C20H23NO2S/c22-24(23)19-9-5-4-8-18(19)10-11-20(24)12-14-21(15-13-20)16-17-6-2-1-3-7-17/h1-9H,10-16H2
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>1.00E+4n/an/an/an/an/an/an/an/a



University of Camerino

Curated by ChEMBL


Assay Description
Compound was tested for its binding affinity towards Alpha-1A adrenergic receptor using [3H]-prazosin from rat submaxillary gland

J Med Chem 41: 1557-60 (1998)


Article DOI: 10.1021/jm970740r
BindingDB Entry DOI: 10.7270/Q2N29W3Q
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(RAT)		BDBM50064175
PNG
(1-benzylspiro[hexahydropyridine-4,2'-(3',4'-dihydr...)
Show SMILES O=S1c2ccccc2CCC11CCN(Cc2ccccc2)CC1
Show InChI InChI=1S/C20H23NOS/c22-23-19-9-5-4-8-18(19)10-11-20(23)12-14-21(15-13-20)16-17-6-2-1-3-7-17/h1-9H,10-16H2
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>1.00E+4n/an/an/an/an/an/an/an/a



University of Camerino

Curated by ChEMBL


Assay Description
Compound was tested for its binding affinity towards Muscarinic acetylcholine receptor M2 using [3H]-NMS from rat heart

J Med Chem 41: 1557-60 (1998)


Article DOI: 10.1021/jm970740r
BindingDB Entry DOI: 10.7270/Q2N29W3Q
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(RAT)		BDBM50064175
PNG
(1-benzylspiro[hexahydropyridine-4,2'-(3',4'-dihydr...)
Show SMILES O=S1c2ccccc2CCC11CCN(Cc2ccccc2)CC1
Show InChI InChI=1S/C20H23NOS/c22-23-19-9-5-4-8-18(19)10-11-20(23)12-14-21(15-13-20)16-17-6-2-1-3-7-17/h1-9H,10-16H2
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>1.00E+4n/an/an/an/an/an/an/an/a



University of Camerino

Curated by ChEMBL


Assay Description
Compound was tested for its binding affinity towards Muscarinic acetylcholine receptor M3 using [3H]-NMS from rat submaxillary gland

J Med Chem 41: 1557-60 (1998)


Article DOI: 10.1021/jm970740r
BindingDB Entry DOI: 10.7270/Q2N29W3Q
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50064175
PNG
(1-benzylspiro[hexahydropyridine-4,2'-(3',4'-dihydr...)
Show SMILES O=S1c2ccccc2CCC11CCN(Cc2ccccc2)CC1
Show InChI InChI=1S/C20H23NOS/c22-23-19-9-5-4-8-18(19)10-11-20(23)12-14-21(15-13-20)16-17-6-2-1-3-7-17/h1-9H,10-16H2
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>1.00E+4n/an/an/an/an/an/an/an/a



University of Camerino

Curated by ChEMBL


Assay Description
Compound was tested for its binding affinity towards Dopamine receptor D2 using [3H]-spiperone from rat striatum

J Med Chem 41: 1557-60 (1998)


Article DOI: 10.1021/jm970740r
BindingDB Entry DOI: 10.7270/Q2N29W3Q
More data for this
Ligand-Target Pair
Alpha-1B adrenergic receptor


(Rattus norvegicus (rat))		BDBM50064175
PNG
(1-benzylspiro[hexahydropyridine-4,2'-(3',4'-dihydr...)
Show SMILES O=S1c2ccccc2CCC11CCN(Cc2ccccc2)CC1
Show InChI InChI=1S/C20H23NOS/c22-23-19-9-5-4-8-18(19)10-11-20(23)12-14-21(15-13-20)16-17-6-2-1-3-7-17/h1-9H,10-16H2
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>1.00E+4n/an/an/an/an/an/an/an/a



University of Camerino

Curated by ChEMBL


Assay Description
Compound was tested for its binding affinity towards Alpha-1B adrenergic receptor using [3H]-prazosin from rat liver

J Med Chem 41: 1557-60 (1998)


Article DOI: 10.1021/jm970740r
BindingDB Entry DOI: 10.7270/Q2N29W3Q
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2C


(Rattus norvegicus (Rat))		BDBM50064173
PNG
(1-benzylspiro[hexahydropyridine-4,2'-(3',4'-dihydr...)
Show SMILES O=S1(=O)c2ccccc2CCC11CCN(Cc2ccccc2)CC1
Show InChI InChI=1S/C20H23NO2S/c22-24(23)19-9-5-4-8-18(19)10-11-20(24)12-14-21(15-13-20)16-17-6-2-1-3-7-17/h1-9H,10-16H2
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>1.00E+4n/an/an/an/an/an/an/an/a



University of Camerino

Curated by ChEMBL


Assay Description
Compound was tested for its binding affinity towards PCP receptor using [3H]-(+)-NANM in the presence of 5 microM haloperidol from rat brain

J Med Chem 41: 1557-60 (1998)


Article DOI: 10.1021/jm970740r
BindingDB Entry DOI: 10.7270/Q2N29W3Q
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2C


(Rattus norvegicus (Rat))		BDBM50036764
PNG
(1'-benzylspiro[1,2,3,4-tetrahydronaphthalene-2,4'-...)
Show SMILES O=C1c2ccccc2CCC11CCN(Cc2ccccc2)CC1
Show InChI InChI=1S/C21H23NO/c23-20-19-9-5-4-8-18(19)10-11-21(20)12-14-22(15-13-21)16-17-6-2-1-3-7-17/h1-9H,10-16H2
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>1.00E+4n/an/an/an/an/an/an/an/a



University of Camerino

Curated by ChEMBL


Assay Description
Compound was tested for its binding affinity towards PCP receptor using [3H]-(+)-NANM in the presence of 5 microM haloperidol from rat brain

J Med Chem 41: 1557-60 (1998)


Article DOI: 10.1021/jm970740r
BindingDB Entry DOI: 10.7270/Q2N29W3Q
More data for this
Ligand-Target Pair
Alpha-1B adrenergic receptor


(Rattus norvegicus (rat))		BDBM50036764
PNG
(1'-benzylspiro[1,2,3,4-tetrahydronaphthalene-2,4'-...)
Show SMILES O=C1c2ccccc2CCC11CCN(Cc2ccccc2)CC1
Show InChI InChI=1S/C21H23NO/c23-20-19-9-5-4-8-18(19)10-11-21(20)12-14-22(15-13-21)16-17-6-2-1-3-7-17/h1-9H,10-16H2
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>1.00E+4n/an/an/an/an/an/an/an/a



University of Camerino

Curated by ChEMBL


Assay Description
Compound was tested for its binding affinity towards Alpha-1B adrenergic receptor using [3H]-prazosin from rat liver

J Med Chem 41: 1557-60 (1998)


Article DOI: 10.1021/jm970740r
BindingDB Entry DOI: 10.7270/Q2N29W3Q
More data for this
Ligand-Target Pair
Alpha-1A adrenergic receptor


(Rattus norvegicus (Rat))		BDBM50064172
PNG
(1-benzylspiro[hexahydropyridine-4,2'-(3',4'-dihydr...)
Show SMILES C(N1CCC2(CC1)CCc1ccccc1S2)c1ccccc1
Show InChI InChI=1S/C20H23NS/c1-2-6-17(7-3-1)16-21-14-12-20(13-15-21)11-10-18-8-4-5-9-19(18)22-20/h1-9H,10-16H2
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>1.00E+4n/an/an/an/an/an/an/an/a



University of Camerino

Curated by ChEMBL


Assay Description
Compound was tested for its binding affinity towards Alpha-1A adrenergic receptor using [3H]-prazosin from rat submaxillary gland

J Med Chem 41: 1557-60 (1998)


Article DOI: 10.1021/jm970740r
BindingDB Entry DOI: 10.7270/Q2N29W3Q
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(RAT)		BDBM50064173
PNG
(1-benzylspiro[hexahydropyridine-4,2'-(3',4'-dihydr...)
Show SMILES O=S1(=O)c2ccccc2CCC11CCN(Cc2ccccc2)CC1
Show InChI InChI=1S/C20H23NO2S/c22-24(23)19-9-5-4-8-18(19)10-11-20(24)12-14-21(15-13-20)16-17-6-2-1-3-7-17/h1-9H,10-16H2
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>1.00E+4n/an/an/an/an/an/an/an/a



University of Camerino

Curated by ChEMBL


Assay Description
Compound was tested for its binding affinity towards Muscarinic acetylcholine receptor M2 using [3H]-NMS from rat heart

J Med Chem 41: 1557-60 (1998)


Article DOI: 10.1021/jm970740r
BindingDB Entry DOI: 10.7270/Q2N29W3Q
More data for this
Ligand-Target Pair
Alpha-1A adrenergic receptor


(Rattus norvegicus (Rat))		BDBM50036764
PNG
(1'-benzylspiro[1,2,3,4-tetrahydronaphthalene-2,4'-...)
Show SMILES O=C1c2ccccc2CCC11CCN(Cc2ccccc2)CC1
Show InChI InChI=1S/C21H23NO/c23-20-19-9-5-4-8-18(19)10-11-21(20)12-14-22(15-13-21)16-17-6-2-1-3-7-17/h1-9H,10-16H2
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>1.00E+4n/an/an/an/an/an/an/an/a



University of Camerino

Curated by ChEMBL


Assay Description
Compound was tested for its binding affinity towards Alpha-1A adrenergic receptor using [3H]-prazosin from rat submaxillary gland

J Med Chem 41: 1557-60 (1998)


Article DOI: 10.1021/jm970740r
BindingDB Entry DOI: 10.7270/Q2N29W3Q
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(RAT)		BDBM50064171
PNG
(1'-benzylspiro[3,4-dihydro-2H-chromene-2,4'-(hexah...)
Show SMILES C(N1CCC2(CC1)CCc1ccccc1O2)c1ccccc1
Show InChI InChI=1S/C20H23NO/c1-2-6-17(7-3-1)16-21-14-12-20(13-15-21)11-10-18-8-4-5-9-19(18)22-20/h1-9H,10-16H2
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>1.00E+4n/an/an/an/an/an/an/an/a



University of Camerino

Curated by ChEMBL


Assay Description
Compound was tested for its binding affinity towards Muscarinic acetylcholine receptor M2 using [3H]-NMS from rat heart

J Med Chem 41: 1557-60 (1998)


Article DOI: 10.1021/jm970740r
BindingDB Entry DOI: 10.7270/Q2N29W3Q
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50064172
PNG
(1-benzylspiro[hexahydropyridine-4,2'-(3',4'-dihydr...)
Show SMILES C(N1CCC2(CC1)CCc1ccccc1S2)c1ccccc1
Show InChI InChI=1S/C20H23NS/c1-2-6-17(7-3-1)16-21-14-12-20(13-15-21)11-10-18-8-4-5-9-19(18)22-20/h1-9H,10-16H2
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 1.04E+4n/an/an/an/an/an/an/an/a



University of Camerino

Curated by ChEMBL


Assay Description
Compound was tested for its binding affinity towards Dopamine receptor D2 using [3H]-spiperone from rat striatum

J Med Chem 41: 1557-60 (1998)


Article DOI: 10.1021/jm970740r
BindingDB Entry DOI: 10.7270/Q2N29W3Q
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(RAT)		BDBM50064172
PNG
(1-benzylspiro[hexahydropyridine-4,2'-(3',4'-dihydr...)
Show SMILES C(N1CCC2(CC1)CCc1ccccc1S2)c1ccccc1
Show InChI InChI=1S/C20H23NS/c1-2-6-17(7-3-1)16-21-14-12-20(13-15-21)11-10-18-8-4-5-9-19(18)22-20/h1-9H,10-16H2
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 1.08E+4n/an/an/an/an/an/an/an/a



University of Camerino

Curated by ChEMBL


Assay Description
Compound was tested for its binding affinity towards Muscarinic acetylcholine receptor M2 using [3H]-NMS from rat heart

J Med Chem 41: 1557-60 (1998)


Article DOI: 10.1021/jm970740r
BindingDB Entry DOI: 10.7270/Q2N29W3Q
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%