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PubMed code 9876115

Compile data set for download or QSAR
Found 183 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM3847
PNG
(1-Phenylbenzimidazole deriv. 64 | 5-Substituted 1-...)
Show SMILES COc1ccc2n(cnc2c1)-c1ccccc1
Show InChI InChI=1S/C14H12N2O/c1-17-12-7-8-14-13(9-12)15-10-16(14)11-5-3-2-4-6-11/h2-10H,1H3
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n/an/a 430n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 5457-65 (1998)


Article DOI: 10.1021/jm9804681
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM3848
PNG
(1-Phenylbenzimidazole deriv. 65 | 1-phenyl-1H-1,3-...)
Show SMILES Oc1ccc2n(cnc2c1)-c1ccccc1
Show InChI InChI=1S/C13H10N2O/c16-11-6-7-13-12(8-11)14-9-15(13)10-4-2-1-3-5-10/h1-9,16H
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n/an/a 440n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 5457-65 (1998)


Article DOI: 10.1021/jm9804681
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM3878
PNG
(1-Phenylbenzimidazole deriv. 95 | 5-methoxy-1-(thi...)
Show SMILES COc1ccc2n(cnc2c1)-c1ccsc1
Show InChI InChI=1S/C12H10N2OS/c1-15-10-2-3-12-11(6-10)13-8-14(12)9-4-5-16-7-9/h2-8H,1H3
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n/an/a 700n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 5457-65 (1998)


Article DOI: 10.1021/jm9804681
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM3851
PNG
(1-Phenylbenzimidazole deriv. 68 | methyl 1-phenyl-...)
Show SMILES COC(=O)c1ccc2n(cnc2c1)-c1ccccc1
Show InChI InChI=1S/C15H12N2O2/c1-19-15(18)11-7-8-14-13(9-11)16-10-17(14)12-5-3-2-4-6-12/h2-10H,1H3
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n/an/a 830n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 5457-65 (1998)


Article DOI: 10.1021/jm9804681
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM3855
PNG
(1-(1-phenyl-1H-1,3-benzodiazol-5-yl)ethan-1-one | ...)
Show SMILES CC(=O)c1ccc2n(cnc2c1)-c1ccccc1
Show InChI InChI=1S/C15H12N2O/c1-11(18)12-7-8-15-14(9-12)16-10-17(15)13-5-3-2-4-6-13/h2-10H,1H3
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n/an/a 860n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 5457-65 (1998)


Article DOI: 10.1021/jm9804681
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM3823
PNG
(1-Phenylbenzimidazole deriv. 40 | 4-(1H-1,3-benzod...)
Show SMILES Oc1ccc(cc1)-n1cnc2ccccc12
Show InChI InChI=1S/C13H10N2O/c16-11-7-5-10(6-8-11)15-9-14-12-3-1-2-4-13(12)15/h1-9,16H
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n/an/a 1.80E+3n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 5457-65 (1998)


Article DOI: 10.1021/jm9804681
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM3860
PNG
(1-Phenylbenzimidazole deriv. 77 | 1-phenyl-1H-1,3-...)
Show SMILES Oc1ccc2ncn(-c3ccccc3)c2c1
Show InChI InChI=1S/C13H10N2O/c16-11-6-7-12-13(8-11)15(9-14-12)10-4-2-1-3-5-10/h1-9,16H
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n/an/a 2.10E+3n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 5457-65 (1998)


Article DOI: 10.1021/jm9804681
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM3877
PNG
(1-Phenylbenzimidazole deriv. 94 | 5-methoxy-1-(thi...)
Show SMILES COc1ccc2n(cnc2c1)-c1cccs1
Show InChI InChI=1S/C12H10N2OS/c1-15-9-4-5-11-10(7-9)13-8-14(11)12-3-2-6-16-12/h2-8H,1H3
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n/an/a 2.50E+3n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 5457-65 (1998)


Article DOI: 10.1021/jm9804681
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM3854
PNG
(1-Phenylbenzimidazole deriv. 71 | 1-phenyl-1H-1,3-...)
Show SMILES Nc1ccc2n(cnc2c1)-c1ccccc1
Show InChI InChI=1S/C13H11N3/c14-10-6-7-13-12(8-10)15-9-16(13)11-4-2-1-3-5-11/h1-9H,14H2
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n/an/a 2.70E+3n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 5457-65 (1998)


Article DOI: 10.1021/jm9804681
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM3816
PNG
(1-Phenylbenzimidazole deriv. 33 | 3-(1H-1,3-benzod...)
Show SMILES Nc1cccc(c1)-n1cnc2ccccc12
Show InChI InChI=1S/C13H11N3/c14-10-4-3-5-11(8-10)16-9-15-12-6-1-2-7-13(12)16/h1-9H,14H2
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n/an/a 3.60E+3n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 5457-65 (1998)


Article DOI: 10.1021/jm9804681
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM3810
PNG
(1-Phenylbenzimidazole deriv. 27 | 3-(1H-1,3-benzod...)
Show SMILES Oc1cccc(c1)-n1cnc2ccccc12
Show InChI InChI=1S/C13H10N2O/c16-11-5-3-4-10(8-11)15-9-14-12-6-1-2-7-13(12)15/h1-9,16H
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n/an/a 3.80E+3n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 5457-65 (1998)


Article DOI: 10.1021/jm9804681
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM3849
PNG
(1-Phenylbenzimidazole deriv. 66 | 5-chloro-1-pheny...)
Show SMILES Clc1ccc2n(cnc2c1)-c1ccccc1
Show InChI InChI=1S/C13H9ClN2/c14-10-6-7-13-12(8-10)15-9-16(13)11-4-2-1-3-5-11/h1-9H
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n/an/a 4.00E+3n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 5457-65 (1998)


Article DOI: 10.1021/jm9804681
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM3846
PNG
(1-Phenylbenzimidazole deriv. 63 | 5-methyl-1-pheny...)
Show SMILES Cc1ccc2n(cnc2c1)-c1ccccc1
Show InChI InChI=1S/C14H12N2/c1-11-7-8-14-13(9-11)15-10-16(14)12-5-3-2-4-6-12/h2-10H,1H3
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n/an/a 4.40E+3n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 5457-65 (1998)


Article DOI: 10.1021/jm9804681
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM3877
PNG
(1-Phenylbenzimidazole deriv. 94 | 5-methoxy-1-(thi...)
Show SMILES COc1ccc2n(cnc2c1)-c1cccs1
Show InChI InChI=1S/C12H10N2OS/c1-15-9-4-5-11-10(7-9)13-8-14(11)12-3-2-6-16-12/h2-8H,1H3
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n/an/a 5.30E+3n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 5457-65 (1998)


Article DOI: 10.1021/jm9804681
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM3861
PNG
(1-Phenylbenzimidazole deriv. 78 | 6-chloro-1-pheny...)
Show SMILES Clc1ccc2ncn(-c3ccccc3)c2c1
Show InChI InChI=1S/C13H9ClN2/c14-10-6-7-12-13(8-10)16(9-15-12)11-4-2-1-3-5-11/h1-9H
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n/an/a 5.40E+3n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 5457-65 (1998)


Article DOI: 10.1021/jm9804681
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM3829
PNG
(1-Phenylbenzimidazole deriv. 46 | 4-(1H-1,3-benzod...)
Show SMILES Nc1ccc(cc1)-n1cnc2ccccc12
Show InChI InChI=1S/C13H11N3/c14-10-5-7-11(8-6-10)16-9-15-12-3-1-2-4-13(12)16/h1-9H,14H2
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n/an/a 5.60E+3n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 5457-65 (1998)


Article DOI: 10.1021/jm9804681
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM3823
PNG
(1-Phenylbenzimidazole deriv. 40 | 4-(1H-1,3-benzod...)
Show SMILES Oc1ccc(cc1)-n1cnc2ccccc12
Show InChI InChI=1S/C13H10N2O/c16-11-7-5-10(6-8-11)15-9-14-12-3-1-2-4-13(12)15/h1-9,16H
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n/an/a 5.80E+3n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 5457-65 (1998)


Article DOI: 10.1021/jm9804681
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM3848
PNG
(1-Phenylbenzimidazole deriv. 65 | 1-phenyl-1H-1,3-...)
Show SMILES Oc1ccc2n(cnc2c1)-c1ccccc1
Show InChI InChI=1S/C13H10N2O/c16-11-6-7-13-12(8-11)14-9-15(13)10-4-2-1-3-5-10/h1-9,16H
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n/an/a 6.40E+3n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 5457-65 (1998)


Article DOI: 10.1021/jm9804681
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM3859
PNG
(1-Phenylbenzimidazole deriv. 76 | 6-methoxy-1-phen...)
Show SMILES COc1ccc2ncn(-c3ccccc3)c2c1
Show InChI InChI=1S/C14H12N2O/c1-17-12-7-8-13-14(9-12)16(10-15-13)11-5-3-2-4-6-11/h2-10H,1H3
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n/an/a 6.40E+3n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 5457-65 (1998)


Article DOI: 10.1021/jm9804681
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM3878
PNG
(1-Phenylbenzimidazole deriv. 95 | 5-methoxy-1-(thi...)
Show SMILES COc1ccc2n(cnc2c1)-c1ccsc1
Show InChI InChI=1S/C12H10N2OS/c1-15-10-2-3-12-11(6-10)13-8-14(12)9-4-5-16-7-9/h2-8H,1H3
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n/an/a 6.50E+3n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 5457-65 (1998)


Article DOI: 10.1021/jm9804681
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM3851
PNG
(1-Phenylbenzimidazole deriv. 68 | methyl 1-phenyl-...)
Show SMILES COC(=O)c1ccc2n(cnc2c1)-c1ccccc1
Show InChI InChI=1S/C15H12N2O2/c1-19-15(18)11-7-8-14-13(9-11)16-10-17(14)12-5-3-2-4-6-12/h2-10H,1H3
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n/an/a 6.60E+3n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 5457-65 (1998)


Article DOI: 10.1021/jm9804681
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM3818
PNG
(1-(3-Formylphenyl)benzimidazole | 1-Phenylbenzimid...)
Show SMILES O=Cc1cccc(c1)-n1cnc2ccccc12
Show InChI InChI=1S/C14H10N2O/c17-9-11-4-3-5-12(8-11)16-10-15-13-6-1-2-7-14(13)16/h1-10H
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n/an/a 6.80E+3n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 5457-65 (1998)


Article DOI: 10.1021/jm9804681
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM3826
PNG
(1-Phenylbenzimidazole deriv. 43 | methyl 4-(1H-1,3...)
Show SMILES COC(=O)c1ccc(cc1)-n1cnc2ccccc12
Show InChI InChI=1S/C15H12N2O2/c1-19-15(18)11-6-8-12(9-7-11)17-10-16-13-4-2-3-5-14(13)17/h2-10H,1H3
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n/an/a 7.20E+3n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 5457-65 (1998)


Article DOI: 10.1021/jm9804681
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM3856
PNG
(1-Phenylbenzimidazole deriv. 73 | 1-phenyl-1H-1,3-...)
Show SMILES O=Cc1ccc2n(cnc2c1)-c1ccccc1
Show InChI InChI=1S/C14H10N2O/c17-9-11-6-7-14-13(8-11)15-10-16(14)12-4-2-1-3-5-12/h1-10H
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n/an/a 8.40E+3n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 5457-65 (1998)


Article DOI: 10.1021/jm9804681
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM3794
PNG
(1-Phenylbenzimidazole 3 | 1-Phenylbenzimidazole de...)
Show SMILES c1nc2ccccc2n1-c1ccccc1
Show InChI InChI=1S/C13H10N2/c1-2-6-11(7-3-1)15-10-14-12-8-4-5-9-13(12)15/h1-10H
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n/an/a 9.30E+3n/an/an/an/a7.425



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 5457-65 (1998)


Article DOI: 10.1021/jm9804681
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM3850
PNG
(1-Phenylbenzimidazole deriv. 67 | 1-phenyl-1H-1,3-...)
Show SMILES OC(=O)c1ccc2n(cnc2c1)-c1ccccc1
Show InChI InChI=1S/C14H10N2O2/c17-14(18)10-6-7-13-12(8-10)15-9-16(13)11-4-2-1-3-5-11/h1-9H,(H,17,18)
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n/an/a 9.30E+3n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 5457-65 (1998)


Article DOI: 10.1021/jm9804681
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM3857
PNG
(1-Phenylbenzimidazole deriv. 74 | 1-Phenylimidazo-...)
Show SMILES c1nc2cnccc2n1-c1ccccc1
Show InChI InChI=1S/C12H9N3/c1-2-4-10(5-3-1)15-9-14-11-8-13-7-6-12(11)15/h1-9H
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n/an/a 1.00E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 5457-65 (1998)


Article DOI: 10.1021/jm9804681
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM3852
PNG
(1-Phenylbenzimidazole deriv. 69 | 1-phenyl-1H-1,3-...)
Show SMILES NC(=O)c1ccc2n(cnc2c1)-c1ccccc1
Show InChI InChI=1S/C14H11N3O/c15-14(18)10-6-7-13-12(8-10)16-9-17(13)11-4-2-1-3-5-11/h1-9H,(H2,15,18)
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n/an/a 1.00E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 5457-65 (1998)


Article DOI: 10.1021/jm9804681
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM3839
PNG
(1-Phenylbenzimidazole 4 | 1-Phenylbenzimidazole de...)
Show SMILES Oc1cccc2n(cnc12)-c1ccccc1
Show InChI InChI=1S/C13H10N2O/c16-12-8-4-7-11-13(12)14-9-15(11)10-5-2-1-3-6-10/h1-9,16H
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n/an/a 1.10E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 5457-65 (1998)


Article DOI: 10.1021/jm9804681
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM3833
PNG
(1-(pyridin-4-yl)-1H-1,3-benzodiazole | 1-Phenylben...)
Show SMILES c1nc2ccccc2n1-c1ccncc1
Show InChI InChI=1S/C12H9N3/c1-2-4-12-11(3-1)14-9-15(12)10-5-7-13-8-6-10/h1-9H
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n/an/a 1.20E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 5457-65 (1998)


Article DOI: 10.1021/jm9804681
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM3831
PNG
(1-Phenylbenzimidazole deriv. 48 | 4-(1H-1,3-benzod...)
Show SMILES O=Cc1ccc(cc1)-n1cnc2ccccc12
Show InChI InChI=1S/C14H10N2O/c17-9-11-5-7-12(8-6-11)16-10-15-13-3-1-2-4-14(13)16/h1-10H
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n/an/a 1.30E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 5457-65 (1998)


Article DOI: 10.1021/jm9804681
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM3822
PNG
(1-(4-methoxyphenyl)-1H-1,3-benzodiazole | 1-Phenyl...)
Show SMILES COc1ccc(cc1)-n1cnc2ccccc12
Show InChI InChI=1S/C14H12N2O/c1-17-12-8-6-11(7-9-12)16-10-15-13-4-2-3-5-14(13)16/h2-10H,1H3
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n/an/a 1.30E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 5457-65 (1998)


Article DOI: 10.1021/jm9804681
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM3863
PNG
(1-Phenylbenzimidazole deriv. 80 | methyl 1-phenyl-...)
Show SMILES COC(=O)c1ccc2ncn(-c3ccccc3)c2c1
Show InChI InChI=1S/C15H12N2O2/c1-19-15(18)11-7-8-13-14(9-11)17(10-16-13)12-5-3-2-4-6-12/h2-10H,1H3
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n/an/a 1.30E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 5457-65 (1998)


Article DOI: 10.1021/jm9804681
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM3855
PNG
(1-(1-phenyl-1H-1,3-benzodiazol-5-yl)ethan-1-one | ...)
Show SMILES CC(=O)c1ccc2n(cnc2c1)-c1ccccc1
Show InChI InChI=1S/C15H12N2O/c1-11(18)12-7-8-15-14(9-12)16-10-17(15)13-5-3-2-4-6-13/h2-10H,1H3
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n/an/a 1.40E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 5457-65 (1998)


Article DOI: 10.1021/jm9804681
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM3853
PNG
(1-Phenylbenzimidazole deriv. 70 | 5-nitro-1-phenyl...)
Show SMILES [O-][N+](=O)c1ccc2n(cnc2c1)-c1ccccc1
Show InChI InChI=1S/C13H9N3O2/c17-16(18)11-6-7-13-12(8-11)14-9-15(13)10-4-2-1-3-5-10/h1-9H
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n/an/a 1.60E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 5457-65 (1998)


Article DOI: 10.1021/jm9804681
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM3852
PNG
(1-Phenylbenzimidazole deriv. 69 | 1-phenyl-1H-1,3-...)
Show SMILES NC(=O)c1ccc2n(cnc2c1)-c1ccccc1
Show InChI InChI=1S/C14H11N3O/c15-14(18)10-6-7-13-12(8-10)16-9-17(13)11-4-2-1-3-5-11/h1-9H,(H2,15,18)
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n/an/a 1.60E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 5457-65 (1998)


Article DOI: 10.1021/jm9804681
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM3832
PNG
(1-Phenylbenzimidazole deriv. 49 | 4-(1H-1,3-benzod...)
Show SMILES N#Cc1ccc(cc1)-n1cnc2ccccc12
Show InChI InChI=1S/C14H9N3/c15-9-11-5-7-12(8-6-11)17-10-16-13-3-1-2-4-14(13)17/h1-8,10H
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n/an/a 1.60E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 5457-65 (1998)


Article DOI: 10.1021/jm9804681
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM3815
PNG
(1-(3-nitrophenyl)-1H-1,3-benzodiazole | 1-Phenylbe...)
Show SMILES [O-][N+](=O)c1cccc(c1)-n1cnc2ccccc12
Show InChI InChI=1S/C13H9N3O2/c17-16(18)11-5-3-4-10(8-11)15-9-14-12-6-1-2-7-13(12)15/h1-9H
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n/an/a 1.60E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 5457-65 (1998)


Article DOI: 10.1021/jm9804681
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM3817
PNG
(1-Phenylbenzimidazole deriv. 34 | 1-[3-(1H-1,3-ben...)
Show SMILES CC(=O)c1cccc(c1)-n1cnc2ccccc12
Show InChI InChI=1S/C15H12N2O/c1-11(18)12-5-4-6-13(9-12)17-10-16-14-7-2-3-8-15(14)17/h2-10H,1H3
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n/an/a 1.90E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 5457-65 (1998)


Article DOI: 10.1021/jm9804681
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM3847
PNG
(1-Phenylbenzimidazole deriv. 64 | 5-Substituted 1-...)
Show SMILES COc1ccc2n(cnc2c1)-c1ccccc1
Show InChI InChI=1S/C14H12N2O/c1-17-12-7-8-14-13(9-12)15-10-16(14)11-5-3-2-4-6-11/h2-10H,1H3
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n/an/a 2.20E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 5457-65 (1998)


Article DOI: 10.1021/jm9804681
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM3827
PNG
(1-(4-Carboxamidophenyl)benzimidazole | 1-Phenylben...)
Show SMILES NC(=O)c1ccc(cc1)-n1cnc2ccccc12
Show InChI InChI=1S/C14H11N3O/c15-14(18)10-5-7-11(8-6-10)17-9-16-12-3-1-2-4-13(12)17/h1-9H,(H2,15,18)
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n/an/a 2.30E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 5457-65 (1998)


Article DOI: 10.1021/jm9804681
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM3866
PNG
(1-Phenylbenzimidazole deriv. 83 | 1-phenyl-1H-1,3-...)
Show SMILES Nc1ccc2ncn(-c3ccccc3)c2c1
Show InChI InChI=1S/C13H11N3/c14-10-6-7-12-13(8-10)16(9-15-12)11-4-2-1-3-5-11/h1-9H,14H2
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n/an/a 2.30E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 5457-65 (1998)


Article DOI: 10.1021/jm9804681
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM3830
PNG
(1-Phenylbenzimidazole deriv. 47 | 1-[4-(1H-1,3-ben...)
Show SMILES CC(=O)c1ccc(cc1)-n1cnc2ccccc12
Show InChI InChI=1S/C15H12N2O/c1-11(18)12-6-8-13(9-7-12)17-10-16-14-4-2-3-5-15(14)17/h2-10H,1H3
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n/an/a 2.40E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 5457-65 (1998)


Article DOI: 10.1021/jm9804681
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM3864
PNG
(1-Phenylbenzimidazole deriv. 81 | 1-phenyl-1H-1,3-...)
Show SMILES NC(=O)c1ccc2ncn(-c3ccccc3)c2c1
Show InChI InChI=1S/C14H11N3O/c15-14(18)10-6-7-12-13(8-10)17(9-16-12)11-4-2-1-3-5-11/h1-9H,(H2,15,18)
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n/an/a 2.50E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 5457-65 (1998)


Article DOI: 10.1021/jm9804681
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM3809
PNG
(1-(3-methoxyphenyl)-1H-1,3-benzodiazole | 1-Phenyl...)
Show SMILES COc1cccc(c1)-n1cnc2ccccc12
Show InChI InChI=1S/C14H12N2O/c1-17-12-6-4-5-11(9-12)16-10-15-13-7-2-3-8-14(13)16/h2-10H,1H3
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n/an/a 2.50E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 5457-65 (1998)


Article DOI: 10.1021/jm9804681
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM3849
PNG
(1-Phenylbenzimidazole deriv. 66 | 5-chloro-1-pheny...)
Show SMILES Clc1ccc2n(cnc2c1)-c1ccccc1
Show InChI InChI=1S/C13H9ClN2/c14-10-6-7-13-12(8-10)15-9-16(13)11-4-2-1-3-5-11/h1-9H
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PubMed
n/an/a 2.80E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 5457-65 (1998)


Article DOI: 10.1021/jm9804681
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM3808
PNG
(1-(3-methylphenyl)-1H-1,3-benzodiazole | 1-Phenylb...)
Show SMILES Cc1cccc(c1)-n1cnc2ccccc12
Show InChI InChI=1S/C14H12N2/c1-11-5-4-6-12(9-11)16-10-15-13-7-2-3-8-14(13)16/h2-10H,1H3
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n/an/a 2.80E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 5457-65 (1998)


Article DOI: 10.1021/jm9804681
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM3876
PNG
(1-Phenyl-1H-imidazo[5,4-b]pyridine Dihydrochloride...)
Show SMILES c1nc2cccnc2n1-c1ccccc1
Show InChI InChI=1S/C12H9N3/c1-2-5-10(6-3-1)15-9-14-11-7-4-8-13-12(11)15/h1-9H
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n/an/a 2.80E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 5457-65 (1998)


Article DOI: 10.1021/jm9804681
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM3828
PNG
(1-(4-nitrophenyl)-1H-1,3-benzodiazole | 1-Phenylbe...)
Show SMILES [O-][N+](=O)c1ccc(cc1)-n1cnc2ccccc12
Show InChI InChI=1S/C13H9N3O2/c17-16(18)11-7-5-10(6-8-11)15-9-14-12-3-1-2-4-13(12)15/h1-9H
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n/an/a 3.00E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 5457-65 (1998)


Article DOI: 10.1021/jm9804681
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM3815
PNG
(1-(3-nitrophenyl)-1H-1,3-benzodiazole | 1-Phenylbe...)
Show SMILES [O-][N+](=O)c1cccc(c1)-n1cnc2ccccc12
Show InChI InChI=1S/C13H9N3O2/c17-16(18)11-5-3-4-10(8-11)15-9-14-12-6-1-2-7-13(12)15/h1-9H
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n/an/a 3.50E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 5457-65 (1998)


Article DOI: 10.1021/jm9804681
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM3854
PNG
(1-Phenylbenzimidazole deriv. 71 | 1-phenyl-1H-1,3-...)
Show SMILES Nc1ccc2n(cnc2c1)-c1ccccc1
Show InChI InChI=1S/C13H11N3/c14-10-6-7-13-12(8-10)15-9-16(13)11-4-2-1-3-5-11/h1-9H,14H2
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n/an/a 3.60E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 5457-65 (1998)


Article DOI: 10.1021/jm9804681
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM3868
PNG
(1-Phenylbenzimidazole deriv. 85 | 7-methoxy-1-phen...)
Show SMILES COc1cccc2ncn(-c3ccccc3)c12
Show InChI InChI=1S/C14H12N2O/c1-17-13-9-5-8-12-14(13)16(10-15-12)11-6-3-2-4-7-11/h2-10H,1H3
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n/an/a 3.70E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 5457-65 (1998)


Article DOI: 10.1021/jm9804681
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM3865
PNG
(1-Phenylbenzimidazole deriv. 82 | 6-nitro-1-phenyl...)
Show SMILES [O-][N+](=O)c1ccc2ncn(-c3ccccc3)c2c1
Show InChI InChI=1S/C13H9N3O2/c17-16(18)11-6-7-12-13(8-11)15(9-14-12)10-4-2-1-3-5-10/h1-9H
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n/an/a 3.90E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 5457-65 (1998)


Article DOI: 10.1021/jm9804681
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM3858
PNG
(1-Phenylbenzimidazole deriv. 75 | 6-Methyl-1-pheny...)
Show SMILES Cc1ccc2ncn(-c3ccccc3)c2c1
Show InChI InChI=1S/C14H12N2/c1-11-7-8-13-14(9-11)16(10-15-13)12-5-3-2-4-6-12/h2-10H,1H3
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n/an/a 4.00E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 5457-65 (1998)


Article DOI: 10.1021/jm9804681
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM3874
PNG
(1-Phenylbenzimidazole deriv. 91 | 7-nitro-1-phenyl...)
Show SMILES [O-][N+](=O)c1cccc2ncn(-c3ccccc3)c12
Show InChI InChI=1S/C13H9N3O2/c17-16(18)12-8-4-7-11-13(12)15(9-14-11)10-5-2-1-3-6-10/h1-9H
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n/an/a 4.00E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 5457-65 (1998)


Article DOI: 10.1021/jm9804681
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM3811
PNG
(1-(3-chlorophenyl)-1H-1,3-benzodiazole | 1-Phenylb...)
Show SMILES Clc1cccc(c1)-n1cnc2ccccc12
Show InChI InChI=1S/C13H9ClN2/c14-10-4-3-5-11(8-10)16-9-15-12-6-1-2-7-13(12)16/h1-9H
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n/an/a 4.70E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 5457-65 (1998)


Article DOI: 10.1021/jm9804681
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM3857
PNG
(1-Phenylbenzimidazole deriv. 74 | 1-Phenylimidazo-...)
Show SMILES c1nc2cnccc2n1-c1ccccc1
Show InChI InChI=1S/C12H9N3/c1-2-4-10(5-3-1)15-9-14-11-8-13-7-6-12(11)15/h1-9H
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n/an/a 4.90E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 5457-65 (1998)


Article DOI: 10.1021/jm9804681
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM3788
PNG
(1-Phenylbenzimidazole deriv. 5 | 1-benzoyl-1H-1,3-...)
Show SMILES O=C(c1ccccc1)n1cnc2ccccc12
Show InChI InChI=1S/C14H10N2O/c17-14(11-6-2-1-3-7-11)16-10-15-12-8-4-5-9-13(12)16/h1-10H
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n/an/a>5.00E+4n/an/an/an/a7.425



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 5457-65 (1998)


Article DOI: 10.1021/jm9804681
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM3803
PNG
(1-Phenylbenzimidazole deriv. 20 | 2-(1H-1,3-benzod...)
Show SMILES Nc1ccccc1-n1cnc2ccccc12
Show InChI InChI=1S/C13H11N3/c14-10-5-1-3-7-12(10)16-9-15-11-6-2-4-8-13(11)16/h1-9H,14H2
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n/an/a>5.00E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 5457-65 (1998)


Article DOI: 10.1021/jm9804681
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM3799
PNG
(1-Phenylbenzimidazole deriv. 16 | 2-(1H-1,3-benzod...)
Show SMILES OC(=O)c1ccccc1-n1cnc2ccccc12
Show InChI InChI=1S/C14H10N2O2/c17-14(18)10-5-1-3-7-12(10)16-9-15-11-6-2-4-8-13(11)16/h1-9H,(H,17,18)
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n/an/a>5.00E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 5457-65 (1998)


Article DOI: 10.1021/jm9804681
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM3811
PNG
(1-(3-chlorophenyl)-1H-1,3-benzodiazole | 1-Phenylb...)
Show SMILES Clc1cccc(c1)-n1cnc2ccccc12
Show InChI InChI=1S/C13H9ClN2/c14-10-4-3-5-11(8-10)16-9-15-12-6-1-2-7-13(12)16/h1-9H
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n/an/a 5.00E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 5457-65 (1998)


Article DOI: 10.1021/jm9804681
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM3812
PNG
(1-Phenylbenzimidazole deriv. 29 | 3-(1H-1,3-benzod...)
Show SMILES OC(=O)c1cccc(c1)-n1cnc2ccccc12
Show InChI InChI=1S/C14H10N2O2/c17-14(18)10-4-3-5-11(8-10)16-9-15-12-6-1-2-7-13(12)16/h1-9H,(H,17,18)
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n/an/a>5.00E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 5457-65 (1998)


Article DOI: 10.1021/jm9804681
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM3821
PNG
(1-(4-methylphenyl)-1H-1,3-benzodiazole | 1-Phenylb...)
Show SMILES Cc1ccc(cc1)-n1cnc2ccccc12
Show InChI InChI=1S/C14H12N2/c1-11-6-8-12(9-7-11)16-10-15-13-4-2-3-5-14(13)16/h2-10H,1H3
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n/an/a>5.00E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 5457-65 (1998)


Article DOI: 10.1021/jm9804681
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM3825
PNG
(1-Phenylbenzimidazole deriv. 42 | 4-(1H-1,3-benzod...)
Show SMILES OC(=O)c1ccc(cc1)-n1cnc2ccccc12
Show InChI InChI=1S/C14H10N2O2/c17-14(18)10-5-7-11(8-6-10)16-9-15-12-3-1-2-4-13(12)16/h1-9H,(H,17,18)
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n/an/a>5.00E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 5457-65 (1998)


Article DOI: 10.1021/jm9804681
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM3818
PNG
(1-(3-Formylphenyl)benzimidazole | 1-Phenylbenzimid...)
Show SMILES O=Cc1cccc(c1)-n1cnc2ccccc12
Show InChI InChI=1S/C14H10N2O/c17-9-11-4-3-5-12(8-11)16-10-15-13-6-1-2-7-14(13)16/h1-10H
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n/an/a 5.00E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 5457-65 (1998)


Article DOI: 10.1021/jm9804681
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM3844
PNG
(1-Phenylbenzimidazole deriv. 61 | 4-Nitro-1-phenyl...)
Show SMILES [O-][N+](=O)c1cccc2n(cnc12)-c1ccccc1
Show InChI InChI=1S/C13H9N3O2/c17-16(18)12-8-4-7-11-13(12)14-9-15(11)10-5-2-1-3-6-10/h1-9H
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n/an/a>5.00E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 5457-65 (1998)


Article DOI: 10.1021/jm9804681
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM3870
PNG
(1-Phenylbenzimidazole deriv. 87 | 7-chloro-1-pheny...)
Show SMILES Clc1cccc2ncn(-c3ccccc3)c12
Show InChI InChI=1S/C13H9ClN2/c14-11-7-4-8-12-13(11)16(9-15-12)10-5-2-1-3-6-10/h1-9H
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n/an/a>5.00E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 5457-65 (1998)


Article DOI: 10.1021/jm9804681
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM3792
PNG
(1-Phenylbenzimidazole deriv. 9 | 1-phenyl-1H-indaz...)
Show SMILES c1nn(-c2ccccc2)c2ccccc12
Show InChI InChI=1S/C13H10N2/c1-2-7-12(8-3-1)15-13-9-5-4-6-11(13)10-14-15/h1-10H
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n/an/a>5.00E+4n/an/an/an/a7.425



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 5457-65 (1998)


Article DOI: 10.1021/jm9804681
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM3792
PNG
(1-Phenylbenzimidazole deriv. 9 | 1-phenyl-1H-indaz...)
Show SMILES c1nn(-c2ccccc2)c2ccccc12
Show InChI InChI=1S/C13H10N2/c1-2-7-12(8-3-1)15-13-9-5-4-6-11(13)10-14-15/h1-10H
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n/an/a>5.00E+4n/an/an/an/a7.425



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 5457-65 (1998)


Article DOI: 10.1021/jm9804681
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM3795
PNG
(1-(2-methylphenyl)-1H-1,3-benzodiazole | 1-Phenylb...)
Show SMILES Cc1ccccc1-n1cnc2ccccc12
Show InChI InChI=1S/C14H12N2/c1-11-6-2-4-8-13(11)16-10-15-12-7-3-5-9-14(12)16/h2-10H,1H3
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n/an/a>5.00E+4n/an/an/an/a7.425



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 5457-65 (1998)


Article DOI: 10.1021/jm9804681
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM3798
PNG
(1-(2-chlorophenyl)-1H-1,3-benzodiazole | 1-Phenylb...)
Show SMILES Clc1ccccc1-n1cnc2ccccc12
Show InChI InChI=1S/C13H9ClN2/c14-10-5-1-3-7-12(10)16-9-15-11-6-2-4-8-13(11)16/h1-9H
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University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 5457-65 (1998)


Article DOI: 10.1021/jm9804681
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM3797
PNG
(1-Phenylbenzimidazole deriv. 14 | 2-(1H-1,3-benzod...)
Show SMILES Oc1ccccc1-n1cnc2ccccc12
Show InChI InChI=1S/C13H10N2O/c16-13-8-4-3-7-12(13)15-9-14-10-5-1-2-6-11(10)15/h1-9,16H
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n/an/a>5.00E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 5457-65 (1998)


Article DOI: 10.1021/jm9804681
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM3802
PNG
(1-(2-nitrophenyl)-1H-1,3-benzodiazole | 1-Phenylbe...)
Show SMILES [O-][N+](=O)c1ccccc1-n1cnc2ccccc12
Show InChI InChI=1S/C13H9N3O2/c17-16(18)13-8-4-3-7-12(13)15-9-14-10-5-1-2-6-11(10)15/h1-9H
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n/an/a>5.00E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 5457-65 (1998)


Article DOI: 10.1021/jm9804681
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM3805
PNG
(1-Phenylbenzimidazole deriv. 22 | 2-(1H-1,3-benzod...)
Show SMILES O=Cc1ccccc1-n1cnc2ccccc12
Show InChI InChI=1S/C14H10N2O/c17-9-11-5-1-3-7-13(11)16-10-15-12-6-2-4-8-14(12)16/h1-10H
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University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 5457-65 (1998)


Article DOI: 10.1021/jm9804681
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM3812
PNG
(1-Phenylbenzimidazole deriv. 29 | 3-(1H-1,3-benzod...)
Show SMILES OC(=O)c1cccc(c1)-n1cnc2ccccc12
Show InChI InChI=1S/C14H10N2O2/c17-14(18)10-4-3-5-11(8-10)16-9-15-12-6-1-2-7-13(12)16/h1-9H,(H,17,18)
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n/an/a>5.00E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 5457-65 (1998)


Article DOI: 10.1021/jm9804681
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM3816
PNG
(1-Phenylbenzimidazole deriv. 33 | 3-(1H-1,3-benzod...)
Show SMILES Nc1cccc(c1)-n1cnc2ccccc12
Show InChI InChI=1S/C13H11N3/c14-10-4-3-5-11(8-10)16-9-15-12-6-1-2-7-13(12)16/h1-9H,14H2
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n/an/a>5.00E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 5457-65 (1998)


Article DOI: 10.1021/jm9804681
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM3796
PNG
(1-(2-Methoxyphenyl)benzimidazole Hydrochloride | 1...)
Show SMILES COc1ccccc1-n1cnc2ccccc12
Show InChI InChI=1S/C14H12N2O/c1-17-14-9-5-4-8-13(14)16-10-15-11-6-2-3-7-12(11)16/h2-10H,1H3
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n/an/a>5.00E+4n/an/an/an/a7.425



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 5457-65 (1998)


Article DOI: 10.1021/jm9804681
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM3817
PNG
(1-Phenylbenzimidazole deriv. 34 | 1-[3-(1H-1,3-ben...)
Show SMILES CC(=O)c1cccc(c1)-n1cnc2ccccc12
Show InChI InChI=1S/C15H12N2O/c1-11(18)12-5-4-6-13(9-12)17-10-16-14-7-2-3-8-15(14)17/h2-10H,1H3
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n/an/a>5.00E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 5457-65 (1998)


Article DOI: 10.1021/jm9804681
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM3838
PNG
(1-Phenylbenzimidazole deriv. 55 | 4-Methoxy-1-phen...)
Show SMILES COc1cccc2n(cnc12)-c1ccccc1
Show InChI InChI=1S/C14H12N2O/c1-17-13-9-5-8-12-14(13)15-10-16(12)11-6-3-2-4-7-11/h2-10H,1H3
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n/an/a 5.00E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 5457-65 (1998)


Article DOI: 10.1021/jm9804681
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM3845
PNG
(1-Phenylbenzimidazole deriv. 62 | 1-phenyl-1H-1,3-...)
Show SMILES Nc1cccc2n(cnc12)-c1ccccc1
Show InChI InChI=1S/C13H11N3/c14-11-7-4-8-12-13(11)15-9-16(12)10-5-2-1-3-6-10/h1-9H,14H2
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University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 5457-65 (1998)


Article DOI: 10.1021/jm9804681
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM3841
PNG
(1-Phenylbenzimidazole deriv. 58 | 1-Phenylbenzimid...)
Show SMILES OC(=O)c1cccc2n(cnc12)-c1ccccc1
Show InChI InChI=1S/C14H10N2O2/c17-14(18)11-7-4-8-12-13(11)15-9-16(12)10-5-2-1-3-6-10/h1-9H,(H,17,18)
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n/an/a>5.00E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 5457-65 (1998)


Article DOI: 10.1021/jm9804681
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM3842
PNG
(1-Phenylbenzimidazole deriv. 59 | Methyl 1-Phenylb...)
Show SMILES COC(=O)c1cccc2n(cnc12)-c1ccccc1
Show InChI InChI=1S/C15H12N2O2/c1-19-15(18)12-8-5-9-13-14(12)16-10-17(13)11-6-3-2-4-7-11/h2-10H,1H3
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n/an/a>5.00E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 5457-65 (1998)


Article DOI: 10.1021/jm9804681
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM3845
PNG
(1-Phenylbenzimidazole deriv. 62 | 1-phenyl-1H-1,3-...)
Show SMILES Nc1cccc2n(cnc12)-c1ccccc1
Show InChI InChI=1S/C13H11N3/c14-11-7-4-8-12-13(11)15-9-16(12)10-5-2-1-3-6-10/h1-9H,14H2
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University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 5457-65 (1998)


Article DOI: 10.1021/jm9804681
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM3846
PNG
(1-Phenylbenzimidazole deriv. 63 | 5-methyl-1-pheny...)
Show SMILES Cc1ccc2n(cnc2c1)-c1ccccc1
Show InChI InChI=1S/C14H12N2/c1-11-7-8-14-13(9-11)15-10-16(14)12-5-3-2-4-6-12/h2-10H,1H3
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University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 5457-65 (1998)


Article DOI: 10.1021/jm9804681
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM3862
PNG
(1-Phenylbenzimidazole deriv. 79 | 1-phenyl-1H-1,3-...)
Show SMILES OC(=O)c1ccc2ncn(-c3ccccc3)c2c1
Show InChI InChI=1S/C14H10N2O2/c17-14(18)10-6-7-12-13(8-10)16(9-15-12)11-4-2-1-3-5-11/h1-9H,(H,17,18)
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n/an/a 5.00E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 5457-65 (1998)


Article DOI: 10.1021/jm9804681
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM3858
PNG
(1-Phenylbenzimidazole deriv. 75 | 6-Methyl-1-pheny...)
Show SMILES Cc1ccc2ncn(-c3ccccc3)c2c1
Show InChI InChI=1S/C14H12N2/c1-11-7-8-13-14(9-11)16(10-15-13)12-5-3-2-4-6-12/h2-10H,1H3
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n/an/a>5.00E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 5457-65 (1998)


Article DOI: 10.1021/jm9804681
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM3866
PNG
(1-Phenylbenzimidazole deriv. 83 | 1-phenyl-1H-1,3-...)
Show SMILES Nc1ccc2ncn(-c3ccccc3)c2c1
Show InChI InChI=1S/C13H11N3/c14-10-6-7-12-13(8-10)16(9-15-12)11-4-2-1-3-5-11/h1-9H,14H2
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University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 5457-65 (1998)


Article DOI: 10.1021/jm9804681
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM3872
PNG
(1-Phenylbenzimidazole deriv. 89 | methyl 1-phenyl-...)
Show SMILES COC(=O)c1cccc2ncn(-c3ccccc3)c12
Show InChI InChI=1S/C15H12N2O2/c1-19-15(18)12-8-5-9-13-14(12)17(10-16-13)11-6-3-2-4-7-11/h2-10H,1H3
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University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 5457-65 (1998)


Article DOI: 10.1021/jm9804681
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM3789
PNG
(1-Phenylbenzimidazole Analog 6 | 2-phenyl-1H-1,3-b...)
Show SMILES c1ccc(cc1)-c1nc2ccccc2[nH]1
Show InChI InChI=1S/C13H10N2/c1-2-6-10(7-3-1)13-14-11-8-4-5-9-12(11)15-13/h1-9H,(H,14,15)
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n/an/a>5.00E+4n/an/an/an/a7.425



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 5457-65 (1998)


Article DOI: 10.1021/jm9804681
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM3791
PNG
(1-Phenylbenzimidazole deriv. 8 | 1-phenyl-1H-indol...)
Show SMILES c1cc2ccccc2n1-c1ccccc1
Show InChI InChI=1S/C14H11N/c1-2-7-13(8-3-1)15-11-10-12-6-4-5-9-14(12)15/h1-11H
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n/an/a>5.00E+4n/an/an/an/a7.425



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 5457-65 (1998)


Article DOI: 10.1021/jm9804681
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM3796
PNG
(1-(2-Methoxyphenyl)benzimidazole Hydrochloride | 1...)
Show SMILES COc1ccccc1-n1cnc2ccccc12
Show InChI InChI=1S/C14H12N2O/c1-17-14-9-5-4-8-13(14)16-10-15-11-6-2-3-7-12(11)16/h2-10H,1H3
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n/an/a>5.00E+4n/an/an/an/a7.425



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 5457-65 (1998)


Article DOI: 10.1021/jm9804681
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM3797
PNG
(1-Phenylbenzimidazole deriv. 14 | 2-(1H-1,3-benzod...)
Show SMILES Oc1ccccc1-n1cnc2ccccc12
Show InChI InChI=1S/C13H10N2O/c16-13-8-4-3-7-12(13)15-9-14-10-5-1-2-6-11(10)15/h1-9,16H
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University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 5457-65 (1998)


Article DOI: 10.1021/jm9804681
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM3800
PNG
(1-Phenylbenzimidazole deriv. 17 | ethyl 2-(1H-1,3-...)
Show SMILES CCOC(=O)c1ccccc1-n1cnc2ccccc12
Show InChI InChI=1S/C16H14N2O2/c1-2-20-16(19)12-7-3-5-9-14(12)18-11-17-13-8-4-6-10-15(13)18/h3-11H,2H2,1H3
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n/an/a>5.00E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 5457-65 (1998)


Article DOI: 10.1021/jm9804681
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM3805
PNG
(1-Phenylbenzimidazole deriv. 22 | 2-(1H-1,3-benzod...)
Show SMILES O=Cc1ccccc1-n1cnc2ccccc12
Show InChI InChI=1S/C14H10N2O/c17-9-11-5-1-3-7-13(11)16-10-15-12-6-2-4-8-14(12)16/h1-10H
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n/an/a>5.00E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 5457-65 (1998)


Article DOI: 10.1021/jm9804681
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM3807
PNG
(1-(pyridin-2-yl)-1H-1,3-benzodiazole | 1-Phenylben...)
Show SMILES c1nc2ccccc2n1-c1ccccn1
Show InChI InChI=1S/C12H9N3/c1-2-6-11-10(5-1)14-9-15(11)12-7-3-4-8-13-12/h1-9H
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n/an/a>5.00E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 5457-65 (1998)


Article DOI: 10.1021/jm9804681
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM3827
PNG
(1-(4-Carboxamidophenyl)benzimidazole | 1-Phenylben...)
Show SMILES NC(=O)c1ccc(cc1)-n1cnc2ccccc12
Show InChI InChI=1S/C14H11N3O/c15-14(18)10-5-7-11(8-6-10)17-9-16-12-3-1-2-4-13(12)17/h1-9H,(H2,15,18)
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n/an/a>5.00E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 5457-65 (1998)


Article DOI: 10.1021/jm9804681
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM3828
PNG
(1-(4-nitrophenyl)-1H-1,3-benzodiazole | 1-Phenylbe...)
Show SMILES [O-][N+](=O)c1ccc(cc1)-n1cnc2ccccc12
Show InChI InChI=1S/C13H9N3O2/c17-16(18)11-7-5-10(6-8-11)15-9-14-12-3-1-2-4-13(12)15/h1-9H
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University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 5457-65 (1998)


Article DOI: 10.1021/jm9804681
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM3829
PNG
(1-Phenylbenzimidazole deriv. 46 | 4-(1H-1,3-benzod...)
Show SMILES Nc1ccc(cc1)-n1cnc2ccccc12
Show InChI InChI=1S/C13H11N3/c14-10-5-7-11(8-6-10)16-9-15-12-3-1-2-4-13(12)16/h1-9H,14H2
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n/an/a>5.00E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 5457-65 (1998)


Article DOI: 10.1021/jm9804681
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM3838
PNG
(1-Phenylbenzimidazole deriv. 55 | 4-Methoxy-1-phen...)
Show SMILES COc1cccc2n(cnc12)-c1ccccc1
Show InChI InChI=1S/C14H12N2O/c1-17-13-9-5-8-12-14(13)15-10-16(12)11-6-3-2-4-7-11/h2-10H,1H3
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University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 5457-65 (1998)


Article DOI: 10.1021/jm9804681
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM3839
PNG
(1-Phenylbenzimidazole 4 | 1-Phenylbenzimidazole de...)
Show SMILES Oc1cccc2n(cnc12)-c1ccccc1
Show InChI InChI=1S/C13H10N2O/c16-12-8-4-7-11-13(12)14-9-15(11)10-5-2-1-3-6-10/h1-9,16H
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n/an/a>5.00E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 5457-65 (1998)


Article DOI: 10.1021/jm9804681
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM3840
PNG
(1-Phenylbenzimidazole deriv. 57 | 4-Chloro-1-pheny...)
Show SMILES Clc1cccc2n(cnc12)-c1ccccc1
Show InChI InChI=1S/C13H9ClN2/c14-11-7-4-8-12-13(11)15-9-16(12)10-5-2-1-3-6-10/h1-9H
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University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 5457-65 (1998)


Article DOI: 10.1021/jm9804681
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM3853
PNG
(1-Phenylbenzimidazole deriv. 70 | 5-nitro-1-phenyl...)
Show SMILES [O-][N+](=O)c1ccc2n(cnc2c1)-c1ccccc1
Show InChI InChI=1S/C13H9N3O2/c17-16(18)11-6-7-13-12(8-11)14-9-15(13)10-4-2-1-3-5-10/h1-9H
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University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 5457-65 (1998)


Article DOI: 10.1021/jm9804681
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM3865
PNG
(1-Phenylbenzimidazole deriv. 82 | 6-nitro-1-phenyl...)
Show SMILES [O-][N+](=O)c1ccc2ncn(-c3ccccc3)c2c1
Show InChI InChI=1S/C13H9N3O2/c17-16(18)11-6-7-12-13(8-11)15(9-14-12)10-4-2-1-3-5-10/h1-9H
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n/an/a 5.00E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 5457-65 (1998)


Article DOI: 10.1021/jm9804681
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM3867
PNG
(1-Phenylbenzimidazole deriv. 84 | 7-methyl-1-pheny...)
Show SMILES Cc1cccc2ncn(-c3ccccc3)c12
Show InChI InChI=1S/C14H12N2/c1-11-6-5-9-13-14(11)16(10-15-13)12-7-3-2-4-8-12/h2-10H,1H3
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n/an/a>5.00E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 5457-65 (1998)


Article DOI: 10.1021/jm9804681
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM3860
PNG
(1-Phenylbenzimidazole deriv. 77 | 1-phenyl-1H-1,3-...)
Show SMILES Oc1ccc2ncn(-c3ccccc3)c2c1
Show InChI InChI=1S/C13H10N2O/c16-11-6-7-12-13(8-11)15(9-14-12)10-4-2-1-3-5-10/h1-9,16H
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University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 5457-65 (1998)


Article DOI: 10.1021/jm9804681
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM3873
PNG
(1-Phenylbenzimidazole deriv. 90 | 1-phenyl-1H-1,3-...)
Show SMILES NC(=O)c1cccc2ncn(-c3ccccc3)c12
Show InChI InChI=1S/C14H11N3O/c15-14(18)11-7-4-8-12-13(11)17(9-16-12)10-5-2-1-3-6-10/h1-9H,(H2,15,18)
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University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 5457-65 (1998)


Article DOI: 10.1021/jm9804681
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM3874
PNG
(1-Phenylbenzimidazole deriv. 91 | 7-nitro-1-phenyl...)
Show SMILES [O-][N+](=O)c1cccc2ncn(-c3ccccc3)c12
Show InChI InChI=1S/C13H9N3O2/c17-16(18)12-8-4-7-11-13(12)15(9-14-11)10-5-2-1-3-6-10/h1-9H
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University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 5457-65 (1998)


Article DOI: 10.1021/jm9804681
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM3789
PNG
(1-Phenylbenzimidazole Analog 6 | 2-phenyl-1H-1,3-b...)
Show SMILES c1ccc(cc1)-c1nc2ccccc2[nH]1
Show InChI InChI=1S/C13H10N2/c1-2-6-10(7-3-1)13-14-11-8-4-5-9-12(11)15-13/h1-9H,(H,14,15)
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n/an/a>5.00E+4n/an/an/an/a7.425



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 5457-65 (1998)


Article DOI: 10.1021/jm9804681
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM3790
PNG
(1-Phenylbenzimidazole Analog 7 | 4-phenyl-2,3-dihy...)
Show SMILES C1CC(=Nc2ccccc2N1)c1ccccc1 |c:2|
Show InChI InChI=1S/C15H14N2/c1-2-6-12(7-3-1)13-10-11-16-14-8-4-5-9-15(14)17-13/h1-9,16H,10-11H2
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n/an/a>5.00E+4n/an/an/an/a7.425



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 5457-65 (1998)


Article DOI: 10.1021/jm9804681
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM3793
PNG
(1-Phenylbenzimidazole deriv. 10 | 1-phenyl-1H-1,2,...)
Show SMILES c1ccc(cc1)-n1nnc2ccccc12
Show InChI InChI=1S/C12H9N3/c1-2-6-10(7-3-1)15-12-9-5-4-8-11(12)13-14-15/h1-9H
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n/an/a>5.00E+4n/an/an/an/a7.425



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 5457-65 (1998)


Article DOI: 10.1021/jm9804681
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM3801
PNG
(1-Phenylbenzimidazole deriv. 18 | 2-(1H-1,3-benzod...)
Show SMILES NC(=O)c1ccccc1-n1cnc2ccccc12
Show InChI InChI=1S/C14H11N3O/c15-14(18)10-5-1-3-7-12(10)17-9-16-11-6-2-4-8-13(11)17/h1-9H,(H2,15,18)
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University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 5457-65 (1998)


Article DOI: 10.1021/jm9804681
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM3813
PNG
(1-Phenylbenzimidazole deriv. 30 | ethyl 3-(1H-1,3-...)
Show SMILES CCOC(=O)c1cccc(c1)-n1cnc2ccccc12
Show InChI InChI=1S/C16H14N2O2/c1-2-20-16(19)12-6-5-7-13(10-12)18-11-17-14-8-3-4-9-15(14)18/h3-11H,2H2,1H3
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University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 5457-65 (1998)


Article DOI: 10.1021/jm9804681
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM3824
PNG
(1-(4-chlorophenyl)-1H-1,3-benzodiazole | 1-Phenylb...)
Show SMILES Clc1ccc(cc1)-n1cnc2ccccc12
Show InChI InChI=1S/C13H9ClN2/c14-10-5-7-11(8-6-10)16-9-15-12-3-1-2-4-13(12)16/h1-9H
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n/an/a 5.00E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 5457-65 (1998)


Article DOI: 10.1021/jm9804681
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM3834
PNG
(1-Phenylbenzimidazole deriv. 51 | 2-methyl-1-pheny...)
Show SMILES Cc1nc2ccccc2n1-c1ccccc1
Show InChI InChI=1S/C14H12N2/c1-11-15-13-9-5-6-10-14(13)16(11)12-7-3-2-4-8-12/h2-10H,1H3
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University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 5457-65 (1998)


Article DOI: 10.1021/jm9804681
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM3832
PNG
(1-Phenylbenzimidazole deriv. 49 | 4-(1H-1,3-benzod...)
Show SMILES N#Cc1ccc(cc1)-n1cnc2ccccc12
Show InChI InChI=1S/C14H9N3/c15-9-11-5-7-12(8-6-11)17-10-16-13-3-1-2-4-14(13)17/h1-8,10H
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University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 5457-65 (1998)


Article DOI: 10.1021/jm9804681
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM3834
PNG
(1-Phenylbenzimidazole deriv. 51 | 2-methyl-1-pheny...)
Show SMILES Cc1nc2ccccc2n1-c1ccccc1
Show InChI InChI=1S/C14H12N2/c1-11-15-13-9-5-6-10-14(13)16(11)12-7-3-2-4-8-12/h2-10H,1H3
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n/an/a>5.00E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 5457-65 (1998)


Article DOI: 10.1021/jm9804681
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM3837
PNG
(1-Phenylbenzimidazole deriv. 54 | 4-Methyl-1-pheny...)
Show SMILES Cc1cccc2n(cnc12)-c1ccccc1
Show InChI InChI=1S/C14H12N2/c1-11-6-5-9-13-14(11)15-10-16(13)12-7-3-2-4-8-12/h2-10H,1H3
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n/an/a>5.00E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 5457-65 (1998)


Article DOI: 10.1021/jm9804681
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM3843
PNG
(1-Phenylbenzimidazole deriv. 60 | 1-Phenylbenzimid...)
Show SMILES NC(=O)c1cccc2n(cnc12)-c1ccccc1
Show InChI InChI=1S/C14H11N3O/c15-14(18)11-7-4-8-12-13(11)16-9-17(12)10-5-2-1-3-6-10/h1-9H,(H2,15,18)
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n/an/a>5.00E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 5457-65 (1998)


Article DOI: 10.1021/jm9804681
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM3856
PNG
(1-Phenylbenzimidazole deriv. 73 | 1-phenyl-1H-1,3-...)
Show SMILES O=Cc1ccc2n(cnc2c1)-c1ccccc1
Show InChI InChI=1S/C14H10N2O/c17-9-11-6-7-14-13(8-11)15-10-16(14)12-4-2-1-3-5-12/h1-10H
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n/an/a>5.00E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 5457-65 (1998)


Article DOI: 10.1021/jm9804681
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM3861
PNG
(1-Phenylbenzimidazole deriv. 78 | 6-chloro-1-pheny...)
Show SMILES Clc1ccc2ncn(-c3ccccc3)c2c1
Show InChI InChI=1S/C13H9ClN2/c14-10-6-7-12-13(8-10)16(9-15-12)11-4-2-1-3-5-11/h1-9H
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n/an/a>5.00E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 5457-65 (1998)


Article DOI: 10.1021/jm9804681
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM3867
PNG
(1-Phenylbenzimidazole deriv. 84 | 7-methyl-1-pheny...)
Show SMILES Cc1cccc2ncn(-c3ccccc3)c12
Show InChI InChI=1S/C14H12N2/c1-11-6-5-9-13-14(11)16(10-15-13)12-7-3-2-4-8-12/h2-10H,1H3
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n/an/a>5.00E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 5457-65 (1998)


Article DOI: 10.1021/jm9804681
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM3871
PNG
(1-Phenylbenzimidazole deriv. 88 | 1-phenyl-1H-1,3-...)
Show SMILES OC(=O)c1cccc2ncn(-c3ccccc3)c12
Show InChI InChI=1S/C14H10N2O2/c17-14(18)11-7-4-8-12-13(11)16(9-15-12)10-5-2-1-3-6-10/h1-9H,(H,17,18)
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n/an/a>5.00E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 5457-65 (1998)


Article DOI: 10.1021/jm9804681
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM3868
PNG
(1-Phenylbenzimidazole deriv. 85 | 7-methoxy-1-phen...)
Show SMILES COc1cccc2ncn(-c3ccccc3)c12
Show InChI InChI=1S/C14H12N2O/c1-17-13-9-5-8-12-14(13)16(10-15-12)11-6-3-2-4-7-11/h2-10H,1H3
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n/an/a 5.00E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 5457-65 (1998)


Article DOI: 10.1021/jm9804681
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM3790
PNG
(1-Phenylbenzimidazole Analog 7 | 4-phenyl-2,3-dihy...)
Show SMILES C1CC(=Nc2ccccc2N1)c1ccccc1 |c:2|
Show InChI InChI=1S/C15H14N2/c1-2-6-12(7-3-1)13-10-11-16-14-8-4-5-9-15(14)17-13/h1-9,16H,10-11H2
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n/an/a>5.00E+4n/an/an/an/a7.425



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 5457-65 (1998)


Article DOI: 10.1021/jm9804681
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM3791
PNG
(1-Phenylbenzimidazole deriv. 8 | 1-phenyl-1H-indol...)
Show SMILES c1cc2ccccc2n1-c1ccccc1
Show InChI InChI=1S/C14H11N/c1-2-7-13(8-3-1)15-11-10-12-6-4-5-9-14(12)15/h1-11H
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n/an/a>5.00E+4n/an/an/an/a7.425



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 5457-65 (1998)


Article DOI: 10.1021/jm9804681
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM3793
PNG
(1-Phenylbenzimidazole deriv. 10 | 1-phenyl-1H-1,2,...)
Show SMILES c1ccc(cc1)-n1nnc2ccccc12
Show InChI InChI=1S/C12H9N3/c1-2-6-10(7-3-1)15-12-9-5-4-8-11(12)13-14-15/h1-9H
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n/an/a>5.00E+4n/an/an/an/a7.425



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 5457-65 (1998)


Article DOI: 10.1021/jm9804681
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM3788
PNG
(1-Phenylbenzimidazole deriv. 5 | 1-benzoyl-1H-1,3-...)
Show SMILES O=C(c1ccccc1)n1cnc2ccccc12
Show InChI InChI=1S/C14H10N2O/c17-14(11-6-2-1-3-7-11)16-10-15-12-8-4-5-9-13(12)16/h1-10H
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n/an/a>5.00E+4n/an/an/an/a7.425



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 5457-65 (1998)


Article DOI: 10.1021/jm9804681
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM3806
PNG
(1-Phenylbenzimidazole deriv. 23 | 2-(1H-1,3-benzod...)
Show SMILES N#Cc1ccccc1-n1cnc2ccccc12
Show InChI InChI=1S/C14H9N3/c15-9-11-5-1-3-7-13(11)17-10-16-12-6-2-4-8-14(12)17/h1-8,10H
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n/an/a>5.00E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 5457-65 (1998)


Article DOI: 10.1021/jm9804681
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM3807
PNG
(1-(pyridin-2-yl)-1H-1,3-benzodiazole | 1-Phenylben...)
Show SMILES c1nc2ccccc2n1-c1ccccn1
Show InChI InChI=1S/C12H9N3/c1-2-6-11-10(5-1)14-9-15(11)12-7-3-4-8-13-12/h1-9H
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n/an/a>5.00E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 5457-65 (1998)


Article DOI: 10.1021/jm9804681
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM3809
PNG
(1-(3-methoxyphenyl)-1H-1,3-benzodiazole | 1-Phenyl...)
Show SMILES COc1cccc(c1)-n1cnc2ccccc12
Show InChI InChI=1S/C14H12N2O/c1-17-12-6-4-5-11(9-12)16-10-15-13-7-2-3-8-14(13)16/h2-10H,1H3
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n/an/a 5.00E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 5457-65 (1998)


Article DOI: 10.1021/jm9804681
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM3810
PNG
(1-Phenylbenzimidazole deriv. 27 | 3-(1H-1,3-benzod...)
Show SMILES Oc1cccc(c1)-n1cnc2ccccc12
Show InChI InChI=1S/C13H10N2O/c16-11-5-3-4-10(8-11)15-9-14-12-6-1-2-7-13(12)15/h1-9,16H
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n/an/a 5.00E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 5457-65 (1998)


Article DOI: 10.1021/jm9804681
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM3824
PNG
(1-(4-chlorophenyl)-1H-1,3-benzodiazole | 1-Phenylb...)
Show SMILES Clc1ccc(cc1)-n1cnc2ccccc12
Show InChI InChI=1S/C13H9ClN2/c14-10-5-7-11(8-6-10)16-9-15-12-3-1-2-4-13(12)16/h1-9H
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n/an/a>5.00E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 5457-65 (1998)


Article DOI: 10.1021/jm9804681
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM3825
PNG
(1-Phenylbenzimidazole deriv. 42 | 4-(1H-1,3-benzod...)
Show SMILES OC(=O)c1ccc(cc1)-n1cnc2ccccc12
Show InChI InChI=1S/C14H10N2O2/c17-14(18)10-5-7-11(8-6-10)16-9-15-12-3-1-2-4-13(12)16/h1-9H,(H,17,18)
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n/an/a>5.00E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 5457-65 (1998)


Article DOI: 10.1021/jm9804681
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM3836
PNG
(1-Phenylbenzimidazole deriv. 53 | 1-phenyl-1H-1,3-...)
Show SMILES Nc1nc2ccccc2n1-c1ccccc1
Show InChI InChI=1S/C13H11N3/c14-13-15-11-8-4-5-9-12(11)16(13)10-6-2-1-3-7-10/h1-9H,(H2,14,15)
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n/an/a>5.00E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 5457-65 (1998)


Article DOI: 10.1021/jm9804681
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM3831
PNG
(1-Phenylbenzimidazole deriv. 48 | 4-(1H-1,3-benzod...)
Show SMILES O=Cc1ccc(cc1)-n1cnc2ccccc12
Show InChI InChI=1S/C14H10N2O/c17-9-11-5-7-12(8-6-11)16-10-15-13-3-1-2-4-14(13)16/h1-10H
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n/an/a>5.00E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 5457-65 (1998)


Article DOI: 10.1021/jm9804681
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM3844
PNG
(1-Phenylbenzimidazole deriv. 61 | 4-Nitro-1-phenyl...)
Show SMILES [O-][N+](=O)c1cccc2n(cnc12)-c1ccccc1
Show InChI InChI=1S/C13H9N3O2/c17-16(18)12-8-4-7-11-13(12)14-9-15(11)10-5-2-1-3-6-10/h1-9H
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n/an/a>5.00E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 5457-65 (1998)


Article DOI: 10.1021/jm9804681
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM3862
PNG
(1-Phenylbenzimidazole deriv. 79 | 1-phenyl-1H-1,3-...)
Show SMILES OC(=O)c1ccc2ncn(-c3ccccc3)c2c1
Show InChI InChI=1S/C14H10N2O2/c17-14(18)10-6-7-12-13(8-10)16(9-15-12)11-4-2-1-3-5-11/h1-9H,(H,17,18)
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n/an/a 5.00E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 5457-65 (1998)


Article DOI: 10.1021/jm9804681
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM3869
PNG
(1-Phenylbenzimidazole deriv. 86 | 1-phenyl-1H-1,3-...)
Show SMILES Oc1cccc2ncn(-c3ccccc3)c12
Show InChI InChI=1S/C13H10N2O/c16-12-8-4-7-11-13(12)15(9-14-11)10-5-2-1-3-6-10/h1-9,16H
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University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 5457-65 (1998)


Article DOI: 10.1021/jm9804681
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM3875
PNG
(1-Phenylbenzimidazole deriv. 92 | 1-phenyl-1H-1,3-...)
Show SMILES Nc1cccc2ncn(-c3ccccc3)c12
Show InChI InChI=1S/C13H11N3/c14-11-7-4-8-12-13(11)16(9-15-12)10-5-2-1-3-6-10/h1-9H,14H2
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n/an/a>5.00E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 5457-65 (1998)


Article DOI: 10.1021/jm9804681
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM3804
PNG
(1-Phenylbenzimidazole deriv. 21 | 1-[2-(1H-1,3-ben...)
Show SMILES CC(=O)c1ccccc1-n1cnc2ccccc12
Show InChI InChI=1S/C15H12N2O/c1-11(18)12-6-2-4-8-14(12)17-10-16-13-7-3-5-9-15(13)17/h2-10H,1H3
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n/an/a>5.00E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 5457-65 (1998)


Article DOI: 10.1021/jm9804681
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM3806
PNG
(1-Phenylbenzimidazole deriv. 23 | 2-(1H-1,3-benzod...)
Show SMILES N#Cc1ccccc1-n1cnc2ccccc12
Show InChI InChI=1S/C14H9N3/c15-9-11-5-1-3-7-13(11)17-10-16-12-6-2-4-8-14(12)17/h1-8,10H
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n/an/a>5.00E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 5457-65 (1998)


Article DOI: 10.1021/jm9804681
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM3803
PNG
(1-Phenylbenzimidazole deriv. 20 | 2-(1H-1,3-benzod...)
Show SMILES Nc1ccccc1-n1cnc2ccccc12
Show InChI InChI=1S/C13H11N3/c14-10-5-1-3-7-12(10)16-9-15-11-6-2-4-8-13(11)16/h1-9H,14H2
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n/an/a>5.00E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 5457-65 (1998)


Article DOI: 10.1021/jm9804681
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM3813
PNG
(1-Phenylbenzimidazole deriv. 30 | ethyl 3-(1H-1,3-...)
Show SMILES CCOC(=O)c1cccc(c1)-n1cnc2ccccc12
Show InChI InChI=1S/C16H14N2O2/c1-2-20-16(19)12-6-5-7-13(10-12)18-11-17-14-8-3-4-9-15(14)18/h3-11H,2H2,1H3
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n/an/a>5.00E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 5457-65 (1998)


Article DOI: 10.1021/jm9804681
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM3814
PNG
(1-Phenylbenzimidazole deriv. 31 | 3-(1H-1,3-benzod...)
Show SMILES NC(=O)c1cccc(c1)-n1cnc2ccccc12
Show InChI InChI=1S/C14H11N3O/c15-14(18)10-4-3-5-11(8-10)17-9-16-12-6-1-2-7-13(12)17/h1-9H,(H2,15,18)
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n/an/a>5.00E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 5457-65 (1998)


Article DOI: 10.1021/jm9804681
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM3795
PNG
(1-(2-methylphenyl)-1H-1,3-benzodiazole | 1-Phenylb...)
Show SMILES Cc1ccccc1-n1cnc2ccccc12
Show InChI InChI=1S/C14H12N2/c1-11-6-2-4-8-13(11)16-10-15-12-7-3-5-9-14(12)16/h2-10H,1H3
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n/an/a>5.00E+4n/an/an/an/a7.425



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 5457-65 (1998)


Article DOI: 10.1021/jm9804681
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM3819
PNG
(1-Phenylbenzimidazole deriv. 36 | 3-(1H-1,3-benzod...)
Show SMILES N#Cc1cccc(c1)-n1cnc2ccccc12
Show InChI InChI=1S/C14H9N3/c15-9-11-4-3-5-12(8-11)17-10-16-13-6-1-2-7-14(13)17/h1-8,10H
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n/an/a>5.00E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 5457-65 (1998)


Article DOI: 10.1021/jm9804681
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM3820
PNG
(1-(pyridin-3-yl)-1H-1,3-benzodiazole | 1-Phenylben...)
Show SMILES c1nc2ccccc2n1-c1cccnc1
Show InChI InChI=1S/C12H9N3/c1-2-6-12-11(5-1)14-9-15(12)10-4-3-7-13-8-10/h1-9H
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n/an/a>5.00E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 5457-65 (1998)


Article DOI: 10.1021/jm9804681
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM3821
PNG
(1-(4-methylphenyl)-1H-1,3-benzodiazole | 1-Phenylb...)
Show SMILES Cc1ccc(cc1)-n1cnc2ccccc12
Show InChI InChI=1S/C14H12N2/c1-11-6-8-12(9-7-11)16-10-15-13-4-2-3-5-14(13)16/h2-10H,1H3
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n/an/a>5.00E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 5457-65 (1998)


Article DOI: 10.1021/jm9804681
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM3822
PNG
(1-(4-methoxyphenyl)-1H-1,3-benzodiazole | 1-Phenyl...)
Show SMILES COc1ccc(cc1)-n1cnc2ccccc12
Show InChI InChI=1S/C14H12N2O/c1-17-12-8-6-11(7-9-12)16-10-15-13-4-2-3-5-14(13)16/h2-10H,1H3
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n/an/a>5.00E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 5457-65 (1998)


Article DOI: 10.1021/jm9804681
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM3826
PNG
(1-Phenylbenzimidazole deriv. 43 | methyl 4-(1H-1,3...)
Show SMILES COC(=O)c1ccc(cc1)-n1cnc2ccccc12
Show InChI InChI=1S/C15H12N2O2/c1-19-15(18)11-6-8-12(9-7-11)17-10-16-13-4-2-3-5-14(13)17/h2-10H,1H3
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n/an/a 5.00E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 5457-65 (1998)


Article DOI: 10.1021/jm9804681
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM3835
PNG
(1-Phenylbenzimidazole deriv. 52 | 1-phenyl-1H-1,3-...)
Show SMILES O=c1[nH]c2ccccc2n1-c1ccccc1
Show InChI InChI=1S/C13H10N2O/c16-13-14-11-8-4-5-9-12(11)15(13)10-6-2-1-3-7-10/h1-9H,(H,14,16)
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n/an/a>5.00E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 5457-65 (1998)


Article DOI: 10.1021/jm9804681
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM3840
PNG
(1-Phenylbenzimidazole deriv. 57 | 4-Chloro-1-pheny...)
Show SMILES Clc1cccc2n(cnc12)-c1ccccc1
Show InChI InChI=1S/C13H9ClN2/c14-11-7-4-8-12-13(11)15-9-16(12)10-5-2-1-3-6-10/h1-9H
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n/an/a>5.00E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 5457-65 (1998)


Article DOI: 10.1021/jm9804681
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM3843
PNG
(1-Phenylbenzimidazole deriv. 60 | 1-Phenylbenzimid...)
Show SMILES NC(=O)c1cccc2n(cnc12)-c1ccccc1
Show InChI InChI=1S/C14H11N3O/c15-14(18)11-7-4-8-12-13(11)16-9-17(12)10-5-2-1-3-6-10/h1-9H,(H2,15,18)
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n/an/a>5.00E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 5457-65 (1998)


Article DOI: 10.1021/jm9804681
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM3864
PNG
(1-Phenylbenzimidazole deriv. 81 | 1-phenyl-1H-1,3-...)
Show SMILES NC(=O)c1ccc2ncn(-c3ccccc3)c2c1
Show InChI InChI=1S/C14H11N3O/c15-14(18)10-6-7-12-13(8-10)17(9-16-12)11-4-2-1-3-5-11/h1-9H,(H2,15,18)
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n/an/a>5.00E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 5457-65 (1998)


Article DOI: 10.1021/jm9804681
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM3869
PNG
(1-Phenylbenzimidazole deriv. 86 | 1-phenyl-1H-1,3-...)
Show SMILES Oc1cccc2ncn(-c3ccccc3)c12
Show InChI InChI=1S/C13H10N2O/c16-12-8-4-7-11-13(12)15(9-14-11)10-5-2-1-3-6-10/h1-9,16H
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n/an/a>5.00E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 5457-65 (1998)


Article DOI: 10.1021/jm9804681
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM3870
PNG
(1-Phenylbenzimidazole deriv. 87 | 7-chloro-1-pheny...)
Show SMILES Clc1cccc2ncn(-c3ccccc3)c12
Show InChI InChI=1S/C13H9ClN2/c14-11-7-4-8-12-13(11)16(9-15-12)10-5-2-1-3-6-10/h1-9H
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n/an/a>5.00E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 5457-65 (1998)


Article DOI: 10.1021/jm9804681
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM3787
PNG
(1-Phenylbenzimidazole deriv. 4 | 1-benzyl-1H-1,3-b...)
Show SMILES C(c1ccccc1)n1cnc2ccccc12
Show InChI InChI=1S/C14H12N2/c1-2-6-12(7-3-1)10-16-11-15-13-8-4-5-9-14(13)16/h1-9,11H,10H2
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n/an/a>5.00E+4n/an/an/an/a7.425



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 5457-65 (1998)


Article DOI: 10.1021/jm9804681
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM3787
PNG
(1-Phenylbenzimidazole deriv. 4 | 1-benzyl-1H-1,3-b...)
Show SMILES C(c1ccccc1)n1cnc2ccccc12
Show InChI InChI=1S/C14H12N2/c1-2-6-12(7-3-1)10-16-11-15-13-8-4-5-9-14(13)16/h1-9,11H,10H2
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n/an/a>5.00E+4n/an/an/an/a7.425



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 5457-65 (1998)


Article DOI: 10.1021/jm9804681
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM3798
PNG
(1-(2-chlorophenyl)-1H-1,3-benzodiazole | 1-Phenylb...)
Show SMILES Clc1ccccc1-n1cnc2ccccc12
Show InChI InChI=1S/C13H9ClN2/c14-10-5-1-3-7-12(10)16-9-15-11-6-2-4-8-13(11)16/h1-9H
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University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 5457-65 (1998)


Article DOI: 10.1021/jm9804681
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM3804
PNG
(1-Phenylbenzimidazole deriv. 21 | 1-[2-(1H-1,3-ben...)
Show SMILES CC(=O)c1ccccc1-n1cnc2ccccc12
Show InChI InChI=1S/C15H12N2O/c1-11(18)12-6-2-4-8-14(12)17-10-16-13-7-3-5-9-15(13)17/h2-10H,1H3
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University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 5457-65 (1998)


Article DOI: 10.1021/jm9804681
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM3819
PNG
(1-Phenylbenzimidazole deriv. 36 | 3-(1H-1,3-benzod...)
Show SMILES N#Cc1cccc(c1)-n1cnc2ccccc12
Show InChI InChI=1S/C14H9N3/c15-9-11-4-3-5-12(8-11)17-10-16-13-6-1-2-7-14(13)17/h1-8,10H
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University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 5457-65 (1998)


Article DOI: 10.1021/jm9804681
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM3830
PNG
(1-Phenylbenzimidazole deriv. 47 | 1-[4-(1H-1,3-ben...)
Show SMILES CC(=O)c1ccc(cc1)-n1cnc2ccccc12
Show InChI InChI=1S/C15H12N2O/c1-11(18)12-6-8-13(9-7-12)17-10-16-14-4-2-3-5-15(14)17/h2-10H,1H3
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n/an/a>5.00E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 5457-65 (1998)


Article DOI: 10.1021/jm9804681
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM3833
PNG
(1-(pyridin-4-yl)-1H-1,3-benzodiazole | 1-Phenylben...)
Show SMILES c1nc2ccccc2n1-c1ccncc1
Show InChI InChI=1S/C12H9N3/c1-2-4-12-11(3-1)14-9-15(12)10-5-7-13-8-6-10/h1-9H
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n/an/a>5.00E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 5457-65 (1998)


Article DOI: 10.1021/jm9804681
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM3836
PNG
(1-Phenylbenzimidazole deriv. 53 | 1-phenyl-1H-1,3-...)
Show SMILES Nc1nc2ccccc2n1-c1ccccc1
Show InChI InChI=1S/C13H11N3/c14-13-15-11-8-4-5-9-12(11)16(13)10-6-2-1-3-7-10/h1-9H,(H2,14,15)
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n/an/a>5.00E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 5457-65 (1998)


Article DOI: 10.1021/jm9804681
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM3841
PNG
(1-Phenylbenzimidazole deriv. 58 | 1-Phenylbenzimid...)
Show SMILES OC(=O)c1cccc2n(cnc12)-c1ccccc1
Show InChI InChI=1S/C14H10N2O2/c17-14(18)11-7-4-8-12-13(11)15-9-16(12)10-5-2-1-3-6-10/h1-9H,(H,17,18)
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n/an/a>5.00E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 5457-65 (1998)


Article DOI: 10.1021/jm9804681
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM3859
PNG
(1-Phenylbenzimidazole deriv. 76 | 6-methoxy-1-phen...)
Show SMILES COc1ccc2ncn(-c3ccccc3)c2c1
Show InChI InChI=1S/C14H12N2O/c1-17-12-7-8-13-14(9-12)16(10-15-13)11-5-3-2-4-6-11/h2-10H,1H3
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n/an/a>5.00E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 5457-65 (1998)


Article DOI: 10.1021/jm9804681
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM3863
PNG
(1-Phenylbenzimidazole deriv. 80 | methyl 1-phenyl-...)
Show SMILES COC(=O)c1ccc2ncn(-c3ccccc3)c2c1
Show InChI InChI=1S/C15H12N2O2/c1-19-15(18)11-7-8-13-14(9-11)17(10-16-13)12-5-3-2-4-6-12/h2-10H,1H3
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n/an/a>5.00E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 5457-65 (1998)


Article DOI: 10.1021/jm9804681
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM3872
PNG
(1-Phenylbenzimidazole deriv. 89 | methyl 1-phenyl-...)
Show SMILES COC(=O)c1cccc2ncn(-c3ccccc3)c12
Show InChI InChI=1S/C15H12N2O2/c1-19-15(18)12-8-5-9-13-14(12)17(10-16-13)11-6-3-2-4-7-11/h2-10H,1H3
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n/an/a>5.00E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 5457-65 (1998)


Article DOI: 10.1021/jm9804681
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM3876
PNG
(1-Phenyl-1H-imidazo[5,4-b]pyridine Dihydrochloride...)
Show SMILES c1nc2cccnc2n1-c1ccccc1
Show InChI InChI=1S/C12H9N3/c1-2-5-10(6-3-1)15-9-14-11-7-4-8-13-12(11)15/h1-9H
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n/an/a>5.00E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 5457-65 (1998)


Article DOI: 10.1021/jm9804681
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM3794
PNG
(1-Phenylbenzimidazole 3 | 1-Phenylbenzimidazole de...)
Show SMILES c1nc2ccccc2n1-c1ccccc1
Show InChI InChI=1S/C13H10N2/c1-2-6-11(7-3-1)15-10-14-12-8-4-5-9-13(12)15/h1-10H
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n/an/a>5.00E+4n/an/an/an/a7.425



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 5457-65 (1998)


Article DOI: 10.1021/jm9804681
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM3799
PNG
(1-Phenylbenzimidazole deriv. 16 | 2-(1H-1,3-benzod...)
Show SMILES OC(=O)c1ccccc1-n1cnc2ccccc12
Show InChI InChI=1S/C14H10N2O2/c17-14(18)10-5-1-3-7-12(10)16-9-15-11-6-2-4-8-13(11)16/h1-9H,(H,17,18)
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n/an/a>5.00E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 5457-65 (1998)


Article DOI: 10.1021/jm9804681
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM3802
PNG
(1-(2-nitrophenyl)-1H-1,3-benzodiazole | 1-Phenylbe...)
Show SMILES [O-][N+](=O)c1ccccc1-n1cnc2ccccc12
Show InChI InChI=1S/C13H9N3O2/c17-16(18)13-8-4-3-7-12(13)15-9-14-10-5-1-2-6-11(10)15/h1-9H
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n/an/a>5.00E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 5457-65 (1998)


Article DOI: 10.1021/jm9804681
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM3800
PNG
(1-Phenylbenzimidazole deriv. 17 | ethyl 2-(1H-1,3-...)
Show SMILES CCOC(=O)c1ccccc1-n1cnc2ccccc12
Show InChI InChI=1S/C16H14N2O2/c1-2-20-16(19)12-7-3-5-9-14(12)18-11-17-13-8-4-6-10-15(13)18/h3-11H,2H2,1H3
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n/an/a>5.00E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 5457-65 (1998)


Article DOI: 10.1021/jm9804681
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM3801
PNG
(1-Phenylbenzimidazole deriv. 18 | 2-(1H-1,3-benzod...)
Show SMILES NC(=O)c1ccccc1-n1cnc2ccccc12
Show InChI InChI=1S/C14H11N3O/c15-14(18)10-5-1-3-7-12(10)17-9-16-11-6-2-4-8-13(11)17/h1-9H,(H2,15,18)
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n/an/a>5.00E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 5457-65 (1998)


Article DOI: 10.1021/jm9804681
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM3814
PNG
(1-Phenylbenzimidazole deriv. 31 | 3-(1H-1,3-benzod...)
Show SMILES NC(=O)c1cccc(c1)-n1cnc2ccccc12
Show InChI InChI=1S/C14H11N3O/c15-14(18)10-4-3-5-11(8-10)17-9-16-12-6-1-2-7-13(12)17/h1-9H,(H2,15,18)
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n/an/a>5.00E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 5457-65 (1998)


Article DOI: 10.1021/jm9804681
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM3808
PNG
(1-(3-methylphenyl)-1H-1,3-benzodiazole | 1-Phenylb...)
Show SMILES Cc1cccc(c1)-n1cnc2ccccc12
Show InChI InChI=1S/C14H12N2/c1-11-5-4-6-12(9-11)16-10-15-13-7-2-3-8-14(13)16/h2-10H,1H3
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n/an/a>5.00E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 5457-65 (1998)


Article DOI: 10.1021/jm9804681
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM3820
PNG
(1-(pyridin-3-yl)-1H-1,3-benzodiazole | 1-Phenylben...)
Show SMILES c1nc2ccccc2n1-c1cccnc1
Show InChI InChI=1S/C12H9N3/c1-2-6-12-11(5-1)14-9-15(12)10-4-3-7-13-8-10/h1-9H
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n/an/a>5.00E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 5457-65 (1998)


Article DOI: 10.1021/jm9804681
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM3835
PNG
(1-Phenylbenzimidazole deriv. 52 | 1-phenyl-1H-1,3-...)
Show SMILES O=c1[nH]c2ccccc2n1-c1ccccc1
Show InChI InChI=1S/C13H10N2O/c16-13-14-11-8-4-5-9-12(11)15(13)10-6-2-1-3-7-10/h1-9H,(H,14,16)
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n/an/a>5.00E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 5457-65 (1998)


Article DOI: 10.1021/jm9804681
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM3842
PNG
(1-Phenylbenzimidazole deriv. 59 | Methyl 1-Phenylb...)
Show SMILES COC(=O)c1cccc2n(cnc12)-c1ccccc1
Show InChI InChI=1S/C15H12N2O2/c1-19-15(18)12-8-5-9-13-14(12)16-10-17(13)11-6-3-2-4-7-11/h2-10H,1H3
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n/an/a>5.00E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 5457-65 (1998)


Article DOI: 10.1021/jm9804681
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM3837
PNG
(1-Phenylbenzimidazole deriv. 54 | 4-Methyl-1-pheny...)
Show SMILES Cc1cccc2n(cnc12)-c1ccccc1
Show InChI InChI=1S/C14H12N2/c1-11-6-5-9-13-14(11)15-10-16(13)12-7-3-2-4-8-12/h2-10H,1H3
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n/an/a>5.00E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 5457-65 (1998)


Article DOI: 10.1021/jm9804681
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM3875
PNG
(1-Phenylbenzimidazole deriv. 92 | 1-phenyl-1H-1,3-...)
Show SMILES Nc1cccc2ncn(-c3ccccc3)c12
Show InChI InChI=1S/C13H11N3/c14-11-7-4-8-12-13(11)16(9-15-12)10-5-2-1-3-6-10/h1-9H,14H2
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n/an/a>5.00E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 5457-65 (1998)


Article DOI: 10.1021/jm9804681
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM3873
PNG
(1-Phenylbenzimidazole deriv. 90 | 1-phenyl-1H-1,3-...)
Show SMILES NC(=O)c1cccc2ncn(-c3ccccc3)c12
Show InChI InChI=1S/C14H11N3O/c15-14(18)11-7-4-8-12-13(11)17(9-16-12)10-5-2-1-3-6-10/h1-9H,(H2,15,18)
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n/an/a>5.00E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 5457-65 (1998)


Article DOI: 10.1021/jm9804681
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM3849
PNG
(1-Phenylbenzimidazole deriv. 66 | 5-chloro-1-pheny...)
Show SMILES Clc1ccc2n(cnc2c1)-c1ccccc1
Show InChI InChI=1S/C13H9ClN2/c14-10-6-7-13-12(8-10)15-9-16(13)11-4-2-1-3-5-11/h1-9H
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n/an/a 5.10E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 5457-65 (1998)


Article DOI: 10.1021/jm9804681
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%