Affinity Data by PubMed id=9934454

PubMed code 9934454

Found 15 hits of Enzyme Inhibition Constant Data
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Histamine H1 receptor (RAT)	BDBM35938 (1-(p-chlorophenyl)-1-(2-pyridyl)-3-N,N-dimethylpro...) Show SMILES CN(C)CCC(c1ccc(Cl)cc1)c1ccccn1 Show InChI	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid UniChem Patents Similars	PubMed	5.5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Schering-Plough Research Institute Curated by ChEMBL					Assay Description Binding affinity against Histamine H1 receptor using receptor binding assay in rat brain membranes				Bioorg Med Chem Lett 8: 3469-74 (1999) BindingDB Entry DOI: 10.7270/Q21J98X8
Schering-Plough Research Institute Curated by ChEMBL					More data for this Ligand-Target Pair
Histamine H1 receptor (RAT)	BDBM50063449 (8-Chloro-11-piperazin-1-yl-6,11-dihydro-5H-benzo[5...) Show SMILES Clc1ccc2C(N3CCNCC3)c3ncccc3CCc2c1 Show InChI	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	6.40	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Schering-Plough Research Institute Curated by ChEMBL					Assay Description Binding affinity against Histamine H1 receptor using receptor binding assay in rat brain membranes				Bioorg Med Chem Lett 8: 3469-74 (1999) BindingDB Entry DOI: 10.7270/Q21J98X8
Schering-Plough Research Institute Curated by ChEMBL					More data for this Ligand-Target Pair
Histamine H1 receptor (RAT)	BDBM50073184 (8-Chloro-11-(4-methyl-piperazin-1-yl)-6,11-dihydro...) Show SMILES CN1CCN(CC1)C1c2ccc(Cl)cc2CCc2cccnc12 Show InChI	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	6.5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Schering-Plough Research Institute Curated by ChEMBL					Assay Description Binding affinity against Histamine H1 receptor using receptor binding assay in rat brain membranes				Bioorg Med Chem Lett 8: 3469-74 (1999) BindingDB Entry DOI: 10.7270/Q21J98X8
Schering-Plough Research Institute Curated by ChEMBL					More data for this Ligand-Target Pair
Histamine H1 receptor (RAT)	BDBM50073186 (4-(8-Chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1...) Show SMILES CN1CCN(CC1=O)C1c2ccc(Cl)cc2CCc2cccnc12 Show InChI	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	49	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Schering-Plough Research Institute Curated by ChEMBL					Assay Description Binding affinity against Histamine H1 receptor using receptor binding assay in rat brain membranes				Bioorg Med Chem Lett 8: 3469-74 (1999) BindingDB Entry DOI: 10.7270/Q21J98X8
Schering-Plough Research Institute Curated by ChEMBL					More data for this Ligand-Target Pair
Histamine H1 receptor (RAT)	BDBM50073172 (4-(8-Chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1...) Show SMILES Clc1ccc2C(N3CCNC(=O)C3)c3ncccc3CCc2c1 Show InChI	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	140	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Schering-Plough Research Institute Curated by ChEMBL					Assay Description Binding affinity against Histamine H1 receptor using receptor binding assay in rat brain membranes				Bioorg Med Chem Lett 8: 3469-74 (1999) BindingDB Entry DOI: 10.7270/Q21J98X8
Schering-Plough Research Institute Curated by ChEMBL					More data for this Ligand-Target Pair
Histamine H1 receptor (RAT)	BDBM50073180 (4-(8-Chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1...) Show SMILES Clc1ccc2C(N3CCN(CC3)C=O)c3ncccc3CCc2c1 Show InChI	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	290	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Schering-Plough Research Institute Curated by ChEMBL					Assay Description Binding affinity against Histamine H1 receptor using receptor binding assay in rat brain membranes				Bioorg Med Chem Lett 8: 3469-74 (1999) BindingDB Entry DOI: 10.7270/Q21J98X8
Schering-Plough Research Institute Curated by ChEMBL					More data for this Ligand-Target Pair
Histamine H1 receptor (RAT)	BDBM50007473 (1-[4-(8-Chloro-5,6-dihydro-benzo[5,6]cyclohepta[1,...) Show SMILES Show InChI	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	PubMed	320	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Schering-Plough Research Institute Curated by ChEMBL					Assay Description Binding affinity against Histamine H1 receptor using receptor binding assay in rat brain membranes				Bioorg Med Chem Lett 8: 3469-74 (1999) BindingDB Entry DOI: 10.7270/Q21J98X8
Schering-Plough Research Institute Curated by ChEMBL					More data for this Ligand-Target Pair
Histamine H1 receptor (RAT)	BDBM50073176 (1-[4-(8-Chloro-6,11-dihydro-5H-benzo[5,6]cyclohept...) Show SMILES Show InChI	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	970	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Schering-Plough Research Institute Curated by ChEMBL					Assay Description Binding affinity against Histamine H1 receptor using receptor binding assay in rat brain membranes				Bioorg Med Chem Lett 8: 3469-74 (1999) BindingDB Entry DOI: 10.7270/Q21J98X8
Schering-Plough Research Institute Curated by ChEMBL					More data for this Ligand-Target Pair
Histamine H1 receptor (RAT)	BDBM50073182 (1-[4-(8-Chloro-6,11-dihydro-5H-benzo[5,6]cyclohept...) Show SMILES Show InChI	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	2.50E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Schering-Plough Research Institute Curated by ChEMBL					Assay Description Binding affinity against Histamine H1 receptor using receptor binding assay in rat brain membranes				Bioorg Med Chem Lett 8: 3469-74 (1999) BindingDB Entry DOI: 10.7270/Q21J98X8
Schering-Plough Research Institute Curated by ChEMBL					More data for this Ligand-Target Pair
Histamine H1 receptor (RAT)	BDBM50403681 (CHEMBL2111767) Show SMILES Show InChI	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	3.60E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Schering-Plough Research Institute Curated by ChEMBL					Assay Description Binding affinity against Histamine H1 receptor using receptor binding assay in rat brain membranes				Bioorg Med Chem Lett 8: 3469-74 (1999) BindingDB Entry DOI: 10.7270/Q21J98X8
Schering-Plough Research Institute Curated by ChEMBL					More data for this Ligand-Target Pair
Histamine H1 receptor (RAT)	BDBM50073175 (1-[4-(8-Chloro-6,11-dihydro-5H-benzo[5,6]cyclohept...) Show SMILES Show InChI	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	3.60E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Schering-Plough Research Institute Curated by ChEMBL					Assay Description Binding affinity against Histamine H1 receptor using receptor binding assay in rat brain membranes				Bioorg Med Chem Lett 8: 3469-74 (1999) BindingDB Entry DOI: 10.7270/Q21J98X8
Schering-Plough Research Institute Curated by ChEMBL					More data for this Ligand-Target Pair
Histamine H1 receptor (RAT)	BDBM50073185 (2-(8-Chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1...) Show SMILES Show InChI	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	3.60E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Schering-Plough Research Institute Curated by ChEMBL					Assay Description Binding affinity against Histamine H1 receptor using receptor binding assay in rat brain membranes				Bioorg Med Chem Lett 8: 3469-74 (1999) BindingDB Entry DOI: 10.7270/Q21J98X8
Schering-Plough Research Institute Curated by ChEMBL					More data for this Ligand-Target Pair
Histamine H1 receptor (RAT)	BDBM50073181 (1-[4-(10,11-Dihydro-5H-dibenzo[a,d]cyclohepten-5-y...) Show SMILES CC(=O)N1CCN(CC1)C1c2ccccc2CCc2ccccc12 Show InChI	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	PubMed	3.70E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Schering-Plough Research Institute Curated by ChEMBL					Assay Description Binding affinity against Histamine H1 receptor using receptor binding assay in rat brain membranes				Bioorg Med Chem Lett 8: 3469-74 (1999) BindingDB Entry DOI: 10.7270/Q21J98X8
Schering-Plough Research Institute Curated by ChEMBL					More data for this Ligand-Target Pair
Histamine H1 receptor (RAT)	BDBM50073173 (1-[4-(8-Chloro-6,11-dihydro-5H-benzo[5,6]cyclohept...) Show SMILES Show InChI	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	5.40E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Schering-Plough Research Institute Curated by ChEMBL					Assay Description Binding affinity against Histamine H1 receptor using receptor binding assay in rat brain membranes				Bioorg Med Chem Lett 8: 3469-74 (1999) BindingDB Entry DOI: 10.7270/Q21J98X8
Schering-Plough Research Institute Curated by ChEMBL					More data for this Ligand-Target Pair
Histamine H1 receptor (RAT)	BDBM50450777 (CHEMBL2448125) Show SMILES Show InChI	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Schering-Plough Research Institute Curated by ChEMBL					Assay Description Binding affinity against Histamine H1 receptor using receptor binding assay in rat brain membranes				Bioorg Med Chem Lett 8: 3469-74 (1999) BindingDB Entry DOI: 10.7270/Q21J98X8
Schering-Plough Research Institute Curated by ChEMBL					More data for this Ligand-Target Pair

* indicates data uncertainty>20%