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USPatent US8497265

Compile Data Set for Download or QSAR

Found 327 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Rattus norvegicus (rat))		BDBM99011
PNG
(US8497265, 467)
Show SMILES Cc1ccc(cn1)-c1cnc(nc1OC1CN(C1)c1ccc2ccccc2n1)N1CCC(CO)CC1
Show InChI InChI=1S/C28H30N6O2/c1-19-6-7-22(14-29-19)24-15-30-28(33-12-10-20(18-35)11-13-33)32-27(24)36-23-16-34(17-23)26-9-8-21-4-2-3-5-25(21)31-26/h2-9,14-15,20,23,35H,10-13,16-18H2,1H3
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n/an/a 0.200n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
Enzyme activity: An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale, Calif).

US Patent US8497265 (2013)


BindingDB Entry DOI: 10.7270/Q2VD6X39
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Rattus norvegicus (rat))		BDBM98900
PNG
(US8497265, 226)
Show SMILES OCC1CCN(CC1)c1ccc(Br)c(OC2CN(C2)c2ccc3ccccc3n2)n1
Show InChI InChI=1S/C23H25BrN4O2/c24-19-6-8-22(27-11-9-16(15-29)10-12-27)26-23(19)30-18-13-28(14-18)21-7-5-17-3-1-2-4-20(17)25-21/h1-8,16,18,29H,9-15H2
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n/an/a 0.229n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
Enzyme activity: An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale, Calif).

US Patent US8497265 (2013)


BindingDB Entry DOI: 10.7270/Q2VD6X39
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Rattus norvegicus (rat))		BDBM99009
PNG
(US8497265, 465)
Show SMILES Cc1cc(ccn1)-c1cnc(nc1OC1CN(C1)c1ccc2ccccc2n1)N1CCC(CO)CC1
Show InChI InChI=1S/C28H30N6O2/c1-19-14-22(8-11-29-19)24-15-30-28(33-12-9-20(18-35)10-13-33)32-27(24)36-23-16-34(17-23)26-7-6-21-4-2-3-5-25(21)31-26/h2-8,11,14-15,20,23,35H,9-10,12-13,16-18H2,1H3
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Amgen Inc.

US Patent


Assay Description
Enzyme activity: An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale, Calif).

US Patent US8497265 (2013)


BindingDB Entry DOI: 10.7270/Q2VD6X39
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Rattus norvegicus (rat))		BDBM99013
PNG
(US8497265, 469)
Show SMILES CC(C)(C)OC(=O)N1CCC(=CC1)c1cnc(nc1OC1CN(C1)c1ccc2ccccc2n1)N1CCC(CO)CC1 |c:10|
Show InChI InChI=1S/C32H40N6O4/c1-32(2,3)42-31(40)37-16-12-23(13-17-37)26-18-33-30(36-14-10-22(21-39)11-15-36)35-29(26)41-25-19-38(20-25)28-9-8-24-6-4-5-7-27(24)34-28/h4-9,12,18,22,25,39H,10-11,13-17,19-21H2,1-3H3
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Amgen Inc.

US Patent


Assay Description
Enzyme activity: An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale, Calif).

US Patent US8497265 (2013)


BindingDB Entry DOI: 10.7270/Q2VD6X39
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Rattus norvegicus (rat))		BDBM99048
PNG
(US8497265, 688)
Show SMILES CC(=O)N1CCC(CC1)c1cnc(nc1OC1CN(C1)c1ccc2ccccc2n1)N1CCC(CO)CC1
Show InChI InChI=1S/C29H36N6O3/c1-20(37)33-14-10-22(11-15-33)25-16-30-29(34-12-8-21(19-36)9-13-34)32-28(25)38-24-17-35(18-24)27-7-6-23-4-2-3-5-26(23)31-27/h2-7,16,21-22,24,36H,8-15,17-19H2,1H3
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Amgen Inc.

US Patent


Assay Description
Enzyme activity: An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale, Calif).

US Patent US8497265 (2013)


BindingDB Entry DOI: 10.7270/Q2VD6X39
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Rattus norvegicus (rat))		BDBM99010
PNG
(US8497265, 466 | US8497265, 470)
Show SMILES COc1ncccc1-c1cnc(nc1OC1CN(C1)c1ccc2ccccc2n1)N1CCC(CO)CC1
Show InChI InChI=1S/C28H30N6O3/c1-36-26-22(6-4-12-29-26)23-15-30-28(33-13-10-19(18-35)11-14-33)32-27(23)37-21-16-34(17-21)25-9-8-20-5-2-3-7-24(20)31-25/h2-9,12,15,19,21,35H,10-11,13-14,16-18H2,1H3
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Amgen Inc.

US Patent


Assay Description
Enzyme activity: An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale, Calif).

US Patent US8497265 (2013)


BindingDB Entry DOI: 10.7270/Q2VD6X39
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Rattus norvegicus (rat))		BDBM98928
PNG
(US8497265, 254)
Show SMILES OCC1CCN(CC1)c1cncc(OC2CN(C2)c2ccc3ccccc3n2)n1
Show InChI InChI=1S/C22H25N5O2/c28-15-16-7-9-26(10-8-16)21-11-23-12-22(25-21)29-18-13-27(14-18)20-6-5-17-3-1-2-4-19(17)24-20/h1-6,11-12,16,18,28H,7-10,13-15H2
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Amgen Inc.

US Patent


Assay Description
Enzyme activity: An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale, Calif).

US Patent US8497265 (2013)


BindingDB Entry DOI: 10.7270/Q2VD6X39
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Rattus norvegicus (rat))		BDBM99052
PNG
(US8497265, 736 | US8497265, 797)
Show SMILES O=C(N1CC(C1)Oc1ncccc1C1=CCOCC1)c1nc2ccccc2[nH]1 |t:15|
Show InChI InChI=1S/C21H20N4O3/c26-21(19-23-17-5-1-2-6-18(17)24-19)25-12-15(13-25)28-20-16(4-3-9-22-20)14-7-10-27-11-8-14/h1-7,9,15H,8,10-13H2,(H,23,24)
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Amgen Inc.

US Patent


Assay Description
Enzyme activity: An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale, Calif).

US Patent US8497265 (2013)


BindingDB Entry DOI: 10.7270/Q2VD6X39
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Rattus norvegicus (rat))		BDBM99052
PNG
(US8497265, 736 | US8497265, 797)
Show SMILES O=C(N1CC(C1)Oc1ncccc1C1=CCOCC1)c1nc2ccccc2[nH]1 |t:15|
Show InChI InChI=1S/C21H20N4O3/c26-21(19-23-17-5-1-2-6-18(17)24-19)25-12-15(13-25)28-20-16(4-3-9-22-20)14-7-10-27-11-8-14/h1-7,9,15H,8,10-13H2,(H,23,24)
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Amgen Inc.

US Patent


Assay Description
Enzyme activity: An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale, Calif).

US Patent US8497265 (2013)


BindingDB Entry DOI: 10.7270/Q2VD6X39
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Rattus norvegicus (rat))		BDBM99012
PNG
(US8497265, 468)
Show SMILES OCC1CCN(CC1)c1ncc(C2=CCOCC2)c(OC2CN(C2)c2ccc3ccccc3n2)n1 |t:13|
Show InChI InChI=1S/C27H31N5O3/c33-18-19-7-11-31(12-8-19)27-28-15-23(20-9-13-34-14-10-20)26(30-27)35-22-16-32(17-22)25-6-5-21-3-1-2-4-24(21)29-25/h1-6,9,15,19,22,33H,7-8,10-14,16-18H2
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Amgen Inc.

US Patent


Assay Description
Enzyme activity: An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale, Calif).

US Patent US8497265 (2013)


BindingDB Entry DOI: 10.7270/Q2VD6X39
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Rattus norvegicus (rat))		BDBM98931
PNG
(US8497265, 343)
Show SMILES Cc1cnc(OC2CN(C2)c2ccc3ccccc3n2)c(c1)N1CCC(CO)CC1
Show InChI InChI=1S/C24H28N4O2/c1-17-12-22(27-10-8-18(16-29)9-11-27)24(25-13-17)30-20-14-28(15-20)23-7-6-19-4-2-3-5-21(19)26-23/h2-7,12-13,18,20,29H,8-11,14-16H2,1H3
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Amgen Inc.

US Patent


Assay Description
Enzyme activity: An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale, Calif).

US Patent US8497265 (2013)


BindingDB Entry DOI: 10.7270/Q2VD6X39
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Rattus norvegicus (rat))		BDBM98932
PNG
(US8497265, 344)
Show SMILES OCC1CCN(CC1)c1cc(F)cnc1OC1CN(C1)c1ccc2ccccc2n1
Show InChI InChI=1S/C23H25FN4O2/c24-18-11-21(27-9-7-16(15-29)8-10-27)23(25-12-18)30-19-13-28(14-19)22-6-5-17-3-1-2-4-20(17)26-22/h1-6,11-12,16,19,29H,7-10,13-15H2
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Amgen Inc.

US Patent


Assay Description
Enzyme activity: An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale, Calif).

US Patent US8497265 (2013)


BindingDB Entry DOI: 10.7270/Q2VD6X39
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Rattus norvegicus (rat))		BDBM98891
PNG
(US8497265, 217 | US8497265, 239)
Show SMILES OCC1CCN(CC1)c1nccnc1OC1CN(C1)c1ccc2ccccc2n1
Show InChI InChI=1S/C22H25N5O2/c28-15-16-7-11-26(12-8-16)21-22(24-10-9-23-21)29-18-13-27(14-18)20-6-5-17-3-1-2-4-19(17)25-20/h1-6,9-10,16,18,28H,7-8,11-15H2
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Amgen Inc.

US Patent


Assay Description
Enzyme activity: An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale, Calif).

US Patent US8497265 (2013)


BindingDB Entry DOI: 10.7270/Q2VD6X39
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Rattus norvegicus (rat))		BDBM99037
PNG
(US8497265, 677)
Show SMILES CC(=O)N1CCC(CC1)c1nc2ccccc2nc1OC1CN(C1)c1ccc2ccccc2n1
Show InChI InChI=1S/C27H27N5O2/c1-18(33)31-14-12-20(13-15-31)26-27(30-24-9-5-4-8-23(24)29-26)34-21-16-32(17-21)25-11-10-19-6-2-3-7-22(19)28-25/h2-11,20-21H,12-17H2,1H3
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n/an/a 2.90n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
Enzyme activity: An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale, Calif).

US Patent US8497265 (2013)


BindingDB Entry DOI: 10.7270/Q2VD6X39
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Rattus norvegicus (rat))		BDBM99010
PNG
(US8497265, 466 | US8497265, 470)
Show SMILES COc1ncccc1-c1cnc(nc1OC1CN(C1)c1ccc2ccccc2n1)N1CCC(CO)CC1
Show InChI InChI=1S/C28H30N6O3/c1-36-26-22(6-4-12-29-26)23-15-30-28(33-13-10-19(18-35)11-14-33)32-27(23)37-21-16-34(17-21)25-9-8-20-5-2-3-7-24(20)31-25/h2-9,12,15,19,21,35H,10-11,13-14,16-18H2,1H3
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Amgen Inc.

US Patent


Assay Description
Enzyme activity: An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale, Calif).

US Patent US8497265 (2013)


BindingDB Entry DOI: 10.7270/Q2VD6X39
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Rattus norvegicus (rat))		BDBM99008
PNG
(US8497265, 464)
Show SMILES COc1cccc(c1)-c1cnc(nc1OC1CN(C1)c1ccc2ccccc2n1)N1CCC(CO)CC1
Show InChI InChI=1S/C29H31N5O3/c1-36-23-7-4-6-22(15-23)25-16-30-29(33-13-11-20(19-35)12-14-33)32-28(25)37-24-17-34(18-24)27-10-9-21-5-2-3-8-26(21)31-27/h2-10,15-16,20,24,35H,11-14,17-19H2,1H3
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Amgen Inc.

US Patent


Assay Description
Enzyme activity: An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale, Calif).

US Patent US8497265 (2013)


BindingDB Entry DOI: 10.7270/Q2VD6X39
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Rattus norvegicus (rat))		BDBM98990
PNG
(US8497265, 446)
Show SMILES Nc1ncc2cc(ccc2n1)-c1nccnc1OC1CN(C1)c1ccc2ccccc2n1
Show InChI InChI=1S/C24H19N7O/c25-24-28-12-17-11-16(5-7-20(17)30-24)22-23(27-10-9-26-22)32-18-13-31(14-18)21-8-6-15-3-1-2-4-19(15)29-21/h1-12,18H,13-14H2,(H2,25,28,30)
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Amgen Inc.

US Patent


Assay Description
Enzyme activity: An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale, Calif).

US Patent US8497265 (2013)


BindingDB Entry DOI: 10.7270/Q2VD6X39
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Rattus norvegicus (rat))		BDBM99146
PNG
(US8497265, 895)
Show SMILES CC(=O)N1CCC(=CC1)c1nccnc1OC1CN(C1)c1ccc2ccccc2n1 |c:6|
Show InChI InChI=1S/C23H23N5O2/c1-16(29)27-12-8-18(9-13-27)22-23(25-11-10-24-22)30-19-14-28(15-19)21-7-6-17-4-2-3-5-20(17)26-21/h2-8,10-11,19H,9,12-15H2,1H3
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Amgen Inc.

US Patent


Assay Description
Enzyme activity: An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale, Calif).

US Patent US8497265 (2013)


BindingDB Entry DOI: 10.7270/Q2VD6X39
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Rattus norvegicus (rat))		BDBM99026
PNG
(US8497265, 659)
Show SMILES FC1(F)CCN(CC1)c1nccnc1OC1CN(C1)c1ccc2ccccc2n1
Show InChI InChI=1S/C21H21F2N5O/c22-21(23)7-11-27(12-8-21)19-20(25-10-9-24-19)29-16-13-28(14-16)18-6-5-15-3-1-2-4-17(15)26-18/h1-6,9-10,16H,7-8,11-14H2
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Amgen Inc.

US Patent


Assay Description
Enzyme activity: An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale, Calif).

US Patent US8497265 (2013)


BindingDB Entry DOI: 10.7270/Q2VD6X39
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Rattus norvegicus (rat))		BDBM98872
PNG
(US8497265, 198)
Show SMILES OCC1CCN(CC1)c1nccnc1OC1CCN(CC1)c1ccc2ccccc2n1
Show InChI InChI=1S/C24H29N5O2/c30-17-18-7-13-29(14-8-18)23-24(26-12-11-25-23)31-20-9-15-28(16-10-20)22-6-5-19-3-1-2-4-21(19)27-22/h1-6,11-12,18,20,30H,7-10,13-17H2
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n/an/a 4.35n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
Enzyme activity: An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale, Calif).

US Patent US8497265 (2013)


BindingDB Entry DOI: 10.7270/Q2VD6X39
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Rattus norvegicus (rat))		BDBM99023
PNG
(US8497265, 479)
Show SMILES COc1ncccc1-c1nc2ccccc2nc1OC1CN(C1)c1ccc2ccccc2n1
Show InChI InChI=1S/C26H21N5O2/c1-32-25-19(8-6-14-27-25)24-26(30-22-11-5-4-10-21(22)29-24)33-18-15-31(16-18)23-13-12-17-7-2-3-9-20(17)28-23/h2-14,18H,15-16H2,1H3
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n/an/a 5.5n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
Enzyme activity: An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale, Calif).

US Patent US8497265 (2013)


BindingDB Entry DOI: 10.7270/Q2VD6X39
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Rattus norvegicus (rat))		BDBM98892
PNG
(US8497265, 218 | US8497265, 241)
Show SMILES N#CC1CCN(CC1)c1nccnc1OC1CN(C1)c1ccc2ccccc2n1
Show InChI InChI=1S/C22H22N6O/c23-13-16-7-11-27(12-8-16)21-22(25-10-9-24-21)29-18-14-28(15-18)20-6-5-17-3-1-2-4-19(17)26-20/h1-6,9-10,16,18H,7-8,11-12,14-15H2
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n/an/a 6.08n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
Enzyme activity: An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale, Calif).

US Patent US8497265 (2013)


BindingDB Entry DOI: 10.7270/Q2VD6X39
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Rattus norvegicus (rat))		BDBM99044
PNG
(US8497265, 684)
Show SMILES CC(=O)N1CCCC(C1)c1cccnc1OC1CN(C1)C(=O)c1nc2ccccc2[nH]1
Show InChI InChI=1S/C23H25N5O3/c1-15(29)27-11-5-6-16(12-27)18-7-4-10-24-22(18)31-17-13-28(14-17)23(30)21-25-19-8-2-3-9-20(19)26-21/h2-4,7-10,16-17H,5-6,11-14H2,1H3,(H,25,26)
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n/an/a 6.47n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
Enzyme activity: An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale, Calif).

US Patent US8497265 (2013)


BindingDB Entry DOI: 10.7270/Q2VD6X39
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Rattus norvegicus (rat))		BDBM99022
PNG
(US8497265, 478)
Show SMILES COc1cccc(c1)-c1nc2ccccc2nc1OC1CN(C1)c1ccc2ccccc2n1
Show InChI InChI=1S/C27H22N4O2/c1-32-20-9-6-8-19(15-20)26-27(30-24-12-5-4-11-23(24)29-26)33-21-16-31(17-21)25-14-13-18-7-2-3-10-22(18)28-25/h2-15,21H,16-17H2,1H3
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n/an/a 6.68n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
Enzyme activity: An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale, Calif).

US Patent US8497265 (2013)


BindingDB Entry DOI: 10.7270/Q2VD6X39
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Rattus norvegicus (rat))		BDBM98934
PNG
(US8497265, 346)
Show SMILES OCC1CCN(CC1)c1ncc(Br)c(OC2CN(C2)c2ccc3ccccc3n2)n1
Show InChI InChI=1S/C22H24BrN5O2/c23-18-11-24-22(27-9-7-15(14-29)8-10-27)26-21(18)30-17-12-28(13-17)20-6-5-16-3-1-2-4-19(16)25-20/h1-6,11,15,17,29H,7-10,12-14H2
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n/an/a 7n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
Enzyme activity: An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale, Calif).

US Patent US8497265 (2013)


BindingDB Entry DOI: 10.7270/Q2VD6X39
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Rattus norvegicus (rat))		BDBM98933
PNG
(US8497265, 345)
Show SMILES OCC1CCN(CC1)c1cnccc1OC1CN(C1)c1ccc2ccccc2n1
Show InChI InChI=1S/C23H26N4O2/c28-16-17-8-11-26(12-9-17)21-13-24-10-7-22(21)29-19-14-27(15-19)23-6-5-18-3-1-2-4-20(18)25-23/h1-7,10,13,17,19,28H,8-9,11-12,14-16H2
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Amgen Inc.

US Patent


Assay Description
Enzyme activity: An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale, Calif).

US Patent US8497265 (2013)


BindingDB Entry DOI: 10.7270/Q2VD6X39
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Rattus norvegicus (rat))		BDBM99007
PNG
(US8497265, 463)
Show SMILES Cc1ccc(cn1)-c1nccnc1OC1CN(C1)c1ccc2ccccc2n1
Show InChI InChI=1S/C22H19N5O/c1-15-6-7-17(12-25-15)21-22(24-11-10-23-21)28-18-13-27(14-18)20-9-8-16-4-2-3-5-19(16)26-20/h2-12,18H,13-14H2,1H3
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Amgen Inc.

US Patent


Assay Description
Enzyme activity: An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale, Calif).

US Patent US8497265 (2013)


BindingDB Entry DOI: 10.7270/Q2VD6X39
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Rattus norvegicus (rat))		BDBM99145
PNG
(US8497265, 894)
Show SMILES CC(=O)N1CCC(CC1)c1nccnc1OC1CN(C1)c1ccc2ccccc2n1
Show InChI InChI=1S/C23H25N5O2/c1-16(29)27-12-8-18(9-13-27)22-23(25-11-10-24-22)30-19-14-28(15-19)21-7-6-17-4-2-3-5-20(17)26-21/h2-7,10-11,18-19H,8-9,12-15H2,1H3
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n/an/a 8.39n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
Enzyme activity: An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale, Calif).

US Patent US8497265 (2013)


BindingDB Entry DOI: 10.7270/Q2VD6X39
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Rattus norvegicus (rat))		BDBM99025
PNG
(US8497265, 481)
Show SMILES OCc1ccc(cc1)-c1nccc(OC2CN(C2)c2ccc3ccccc3n2)n1
Show InChI InChI=1S/C23H20N4O2/c28-15-16-5-7-18(8-6-16)23-24-12-11-22(26-23)29-19-13-27(14-19)21-10-9-17-3-1-2-4-20(17)25-21/h1-12,19,28H,13-15H2
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n/an/a 8.45n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
Enzyme activity: An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale, Calif).

US Patent US8497265 (2013)


BindingDB Entry DOI: 10.7270/Q2VD6X39
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Rattus norvegicus (rat))		BDBM98890
PNG
(US8497265, 216)
Show SMILES NC(=O)C1CCN(CC1)c1nccnc1OC1CN(C1)c1ccc2ccccc2n1
Show InChI InChI=1S/C22H24N6O2/c23-20(29)16-7-11-27(12-8-16)21-22(25-10-9-24-21)30-17-13-28(14-17)19-6-5-15-3-1-2-4-18(15)26-19/h1-6,9-10,16-17H,7-8,11-14H2,(H2,23,29)
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n/an/a 9.68n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
Enzyme activity: An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale, Calif).

US Patent US8497265 (2013)


BindingDB Entry DOI: 10.7270/Q2VD6X39
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Rattus norvegicus (rat))		BDBM98993
PNG
(US8497265, 449)
Show SMILES Clc1ccc(cn1)-c1nccnc1OC1CN(C1)c1ccc2ccccc2n1
Show InChI InChI=1S/C21H16ClN5O/c22-18-7-5-15(11-25-18)20-21(24-10-9-23-20)28-16-12-27(13-16)19-8-6-14-3-1-2-4-17(14)26-19/h1-11,16H,12-13H2
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Amgen Inc.

US Patent


Assay Description
Enzyme activity: An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale, Calif).

US Patent US8497265 (2013)


BindingDB Entry DOI: 10.7270/Q2VD6X39
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Rattus norvegicus (rat))		BDBM98898
PNG
(US8497265, 224)
Show SMILES OCC1CCN(CC1)c1nc2ccccc2nc1OC1CN(C1)c1ccc2ccccc2n1
Show InChI InChI=1S/C26H27N5O2/c32-17-18-11-13-30(14-12-18)25-26(29-23-8-4-3-7-22(23)28-25)33-20-15-31(16-20)24-10-9-19-5-1-2-6-21(19)27-24/h1-10,18,20,32H,11-17H2
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n/an/a 9.75n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
Enzyme activity: An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale, Calif).

US Patent US8497265 (2013)


BindingDB Entry DOI: 10.7270/Q2VD6X39
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Rattus norvegicus (rat))		BDBM99126
PNG
(US8497265, 875)
Show SMILES C1CC(CCO1)c1cccnc1OC1CCN(CC1)c1ccc2ccccc2n1
Show InChI InChI=1S/C24H27N3O2/c1-2-6-22-19(4-1)7-8-23(26-22)27-14-9-20(10-15-27)29-24-21(5-3-13-25-24)18-11-16-28-17-12-18/h1-8,13,18,20H,9-12,14-17H2
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Amgen Inc.

US Patent


Assay Description
Enzyme activity: An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale, Calif).

US Patent US8497265 (2013)


BindingDB Entry DOI: 10.7270/Q2VD6X39
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Rattus norvegicus (rat))		BDBM98901
PNG
(US8497265, 227)
Show SMILES OCC1CCN(CC1)c1ncc(Cl)c(OC2CN(C2)c2ccc3ccccc3n2)n1
Show InChI InChI=1S/C22H24ClN5O2/c23-18-11-24-22(27-9-7-15(14-29)8-10-27)26-21(18)30-17-12-28(13-17)20-6-5-16-3-1-2-4-19(16)25-20/h1-6,11,15,17,29H,7-10,12-14H2
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n/an/a 10n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
Enzyme activity: An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale, Calif).

US Patent US8497265 (2013)


BindingDB Entry DOI: 10.7270/Q2VD6X39
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Rattus norvegicus (rat))		BDBM99042
PNG
(US8497265, 682)
Show SMILES CC(=O)N1CCC(=CC1)c1nccnc1OC1CN(C1)C(=O)c1nc2ccccc2[nH]1 |c:6|
Show InChI InChI=1S/C22H22N6O3/c1-14(29)27-10-6-15(7-11-27)19-21(24-9-8-23-19)31-16-12-28(13-16)22(30)20-25-17-4-2-3-5-18(17)26-20/h2-6,8-9,16H,7,10-13H2,1H3,(H,25,26)
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n/an/a 10.4n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
Enzyme activity: An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale, Calif).

US Patent US8497265 (2013)


BindingDB Entry DOI: 10.7270/Q2VD6X39
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Rattus norvegicus (rat))		BDBM98996
PNG
(US8497265, 452)
Show SMILES OCc1ccc(cc1)-c1nccnc1OC1CN(C1)c1ccc2ccccc2n1
Show InChI InChI=1S/C23H20N4O2/c28-15-16-5-7-18(8-6-16)22-23(25-12-11-24-22)29-19-13-27(14-19)21-10-9-17-3-1-2-4-20(17)26-21/h1-12,19,28H,13-15H2
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n/an/a 10.5n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
Enzyme activity: An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale, Calif).

US Patent US8497265 (2013)


BindingDB Entry DOI: 10.7270/Q2VD6X39
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Rattus norvegicus (rat))		BDBM98970
PNG
(US8497265, 426)
Show SMILES CC(=O)c1cccc(c1)-c1nccnc1OC1CN(C1)c1ccc2ccccc2n1
Show InChI InChI=1S/C24H20N4O2/c1-16(29)18-6-4-7-19(13-18)23-24(26-12-11-25-23)30-20-14-28(15-20)22-10-9-17-5-2-3-8-21(17)27-22/h2-13,20H,14-15H2,1H3
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Amgen Inc.

US Patent


Assay Description
Enzyme activity: An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale, Calif).

US Patent US8497265 (2013)


BindingDB Entry DOI: 10.7270/Q2VD6X39
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Rattus norvegicus (rat))		BDBM99050
PNG
(US8497265, 734)
Show SMILES C1C(CN1c1ccc2ccccc2n1)Oc1ncccc1N1CCOCC1
Show InChI InChI=1S/C21H22N4O2/c1-2-5-18-16(4-1)7-8-20(23-18)25-14-17(15-25)27-21-19(6-3-9-22-21)24-10-12-26-13-11-24/h1-9,17H,10-15H2
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n/an/a 12n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
Enzyme activity: An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale, Calif).

US Patent US8497265 (2013)


BindingDB Entry DOI: 10.7270/Q2VD6X39
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Rattus norvegicus (rat))		BDBM98914
PNG
(US8497265, 240)
Show SMILES OCCC1CCN(CC1)c1nccnc1OC1CN(C1)c1ccc2ccccc2n1
Show InChI InChI=1S/C23H27N5O2/c29-14-9-17-7-12-27(13-8-17)22-23(25-11-10-24-22)30-19-15-28(16-19)21-6-5-18-3-1-2-4-20(18)26-21/h1-6,10-11,17,19,29H,7-9,12-16H2
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n/an/a 12.4n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
Enzyme activity: An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale, Calif).

US Patent US8497265 (2013)


BindingDB Entry DOI: 10.7270/Q2VD6X39
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Rattus norvegicus (rat))		BDBM99004
PNG
(US8497265, 460)
Show SMILES Cc1cc(ccn1)-c1nccnc1OC1CN(C1)c1ccc2ccccc2n1
Show InChI InChI=1S/C22H19N5O/c1-15-12-17(8-9-23-15)21-22(25-11-10-24-21)28-18-13-27(14-18)20-7-6-16-4-2-3-5-19(16)26-20/h2-12,18H,13-14H2,1H3
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Amgen Inc.

US Patent


Assay Description
Enzyme activity: An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale, Calif).

US Patent US8497265 (2013)


BindingDB Entry DOI: 10.7270/Q2VD6X39
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Rattus norvegicus (rat))		BDBM98999
PNG
(US8497265, 455)
Show SMILES C1C(CN1c1ccc2ccccc2n1)Oc1nccnc1-c1cccnc1
Show InChI InChI=1S/C21H17N5O/c1-2-6-18-15(4-1)7-8-19(25-18)26-13-17(14-26)27-21-20(23-10-11-24-21)16-5-3-9-22-12-16/h1-12,17H,13-14H2
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n/an/a 13.7n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
Enzyme activity: An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale, Calif).

US Patent US8497265 (2013)


BindingDB Entry DOI: 10.7270/Q2VD6X39
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Rattus norvegicus (rat))		BDBM98894
PNG
(US8497265, 220)
Show SMILES OCC1CCN(CC1)c1nccnc1OC1CN(C1)c1ncc2ccccc2n1
Show InChI InChI=1S/C21H24N6O2/c28-14-15-5-9-26(10-6-15)19-20(23-8-7-22-19)29-17-12-27(13-17)21-24-11-16-3-1-2-4-18(16)25-21/h1-4,7-8,11,15,17,28H,5-6,9-10,12-14H2
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Amgen Inc.

US Patent


Assay Description
Enzyme activity: An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale, Calif).

US Patent US8497265 (2013)


BindingDB Entry DOI: 10.7270/Q2VD6X39
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Rattus norvegicus (rat))		BDBM99061
PNG
(US8497265, 762)
Show SMILES OCC1CCN(CC1)c1nccc(OC2CN(C2)c2ccc3ccccc3n2)n1
Show InChI InChI=1S/C22H25N5O2/c28-15-16-8-11-26(12-9-16)22-23-10-7-21(25-22)29-18-13-27(14-18)20-6-5-17-3-1-2-4-19(17)24-20/h1-7,10,16,18,28H,8-9,11-15H2
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Amgen Inc.

US Patent


Assay Description
Enzyme activity: An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale, Calif).

US Patent US8497265 (2013)


BindingDB Entry DOI: 10.7270/Q2VD6X39
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Rattus norvegicus (rat))		BDBM98908
PNG
(US8497265, 234)
Show SMILES OCC1CCN(CC1)c1ncc(Br)c(OC2CN(C2)c2ncc3ccccc3n2)n1
Show InChI InChI=1S/C21H23BrN6O2/c22-17-10-24-21(27-7-5-14(13-29)6-8-27)26-19(17)30-16-11-28(12-16)20-23-9-15-3-1-2-4-18(15)25-20/h1-4,9-10,14,16,29H,5-8,11-13H2
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Amgen Inc.

US Patent


Assay Description
Enzyme activity: An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale, Calif).

US Patent US8497265 (2013)


BindingDB Entry DOI: 10.7270/Q2VD6X39
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Rattus norvegicus (rat))		BDBM98988
PNG
(US8497265, 444)
Show SMILES C1C(CN1c1ccc2ccccc2n1)Oc1nccnc1C1=CCOCC1 |t:25|
Show InChI InChI=1S/C21H20N4O2/c1-2-4-18-15(3-1)5-6-19(24-18)25-13-17(14-25)27-21-20(22-9-10-23-21)16-7-11-26-12-8-16/h1-7,9-10,17H,8,11-14H2
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Amgen Inc.

US Patent


Assay Description
Enzyme activity: An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale, Calif).

US Patent US8497265 (2013)


BindingDB Entry DOI: 10.7270/Q2VD6X39
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Rattus norvegicus (rat))		BDBM98974
PNG
(US8497265, 430)
Show SMILES CNC(=O)c1ccc(cc1)-c1nccnc1OC1CN(C1)c1ccc2ccccc2n1
Show InChI InChI=1S/C24H21N5O2/c1-25-23(30)18-8-6-17(7-9-18)22-24(27-13-12-26-22)31-19-14-29(15-19)21-11-10-16-4-2-3-5-20(16)28-21/h2-13,19H,14-15H2,1H3,(H,25,30)
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Amgen Inc.

US Patent


Assay Description
Enzyme activity: An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale, Calif).

US Patent US8497265 (2013)


BindingDB Entry DOI: 10.7270/Q2VD6X39
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Rattus norvegicus (rat))		BDBM98969
PNG
(US8497265, 425)
Show SMILES CN(C)C(=O)c1ccc(cc1)-c1nccnc1OC1CN(C1)c1ccc2ccccc2n1
Show InChI InChI=1S/C25H23N5O2/c1-29(2)25(31)19-9-7-18(8-10-19)23-24(27-14-13-26-23)32-20-15-30(16-20)22-12-11-17-5-3-4-6-21(17)28-22/h3-14,20H,15-16H2,1-2H3
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Amgen Inc.

US Patent


Assay Description
Enzyme activity: An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale, Calif).

US Patent US8497265 (2013)


BindingDB Entry DOI: 10.7270/Q2VD6X39
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Rattus norvegicus (rat))		BDBM98929
PNG
(US8497265, 341)
Show SMILES Fc1cnc(OC2CN(C2)c2ccc3ccccc3n2)c(c1)N1CCC(CC1)C#N
Show InChI InChI=1S/C23H22FN5O/c24-18-11-21(28-9-7-16(12-25)8-10-28)23(26-13-18)30-19-14-29(15-19)22-6-5-17-3-1-2-4-20(17)27-22/h1-6,11,13,16,19H,7-10,14-15H2
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Amgen Inc.

US Patent


Assay Description
Enzyme activity: An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale, Calif).

US Patent US8497265 (2013)


BindingDB Entry DOI: 10.7270/Q2VD6X39
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Rattus norvegicus (rat))		BDBM99055
PNG
(US8497265, 739)
Show SMILES CC(C)(C)OC(=O)N1CC(C1)Oc1ncccc1[C@H]1CC[C@H](O)CC1 |r,wU:18.19,wD:21.23,(6.28,-2.85,;4.94,-3.62,;4.94,-5.16,;6.28,-4.39,;3.61,-2.85,;2.28,-3.62,;2.28,-5.16,;.94,-2.85,;-.54,-3.25,;-.94,-1.77,;.54,-1.37,;-2.28,-1,;-3.61,-1.77,;-3.61,-3.31,;-4.94,-4.08,;-6.28,-3.31,;-6.28,-1.77,;-4.94,-1,;-4.94,.54,;-6.28,1.31,;-6.28,2.85,;-4.94,3.62,;-4.94,5.16,;-3.61,2.85,;-3.61,1.31,)|
Show InChI InChI=1S/C19H28N2O4/c1-19(2,3)25-18(23)21-11-15(12-21)24-17-16(5-4-10-20-17)13-6-8-14(22)9-7-13/h4-5,10,13-15,22H,6-9,11-12H2,1-3H3/t13-,14-
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n/an/a 15.8n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
Enzyme activity: An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale, Calif).

US Patent US8497265 (2013)


BindingDB Entry DOI: 10.7270/Q2VD6X39
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Rattus norvegicus (rat))		BDBM98937
PNG
(US8497265, 349)
Show SMILES OCC1CCN(CC1)c1ncc(N2CCCCC2)c(OC2CN(C2)c2ccc3ccccc3n2)n1
Show InChI InChI=1S/C27H34N6O2/c34-19-20-10-14-32(15-11-20)27-28-16-24(31-12-4-1-5-13-31)26(30-27)35-22-17-33(18-22)25-9-8-21-6-2-3-7-23(21)29-25/h2-3,6-9,16,20,22,34H,1,4-5,10-15,17-19H2
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n/an/a 18.4n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
Enzyme activity: An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale, Calif).

US Patent US8497265 (2013)


BindingDB Entry DOI: 10.7270/Q2VD6X39
More data for this
Ligand-Target Pair
Displayed 1 to 50 (of 327 total )  |  Next  |  Last  >>
* indicates data uncertainty>20%