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USPatent US8796330

Compile data set for download or QSAR
Found 80 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Histone deacetylase 1


(Homo sapiens (Human))		BDBM50123975
PNG
(3-[4-(biphenyl-4-sulfonylamino)-phenyl]-N-hydroxy-...)
Show SMILES ONC(=O)\C=C\c1ccc(NS(=O)(=O)c2ccc(cc2)-c2ccccc2)cc1
Show InChI InChI=1S/C21H18N2O4S/c24-21(22-25)15-8-16-6-11-19(12-7-16)23-28(26,27)20-13-9-18(10-14-20)17-4-2-1-3-5-17/h1-15,23,25H,(H,22,24)/b15-8+
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US Patent
n/an/a 10n/an/an/an/an/a37



Methylgene Inc.

US Patent


Assay Description
For deacetylase assays, 20,000 cpm of the [3H]-metabolically labeled acetylated histone substrate (M. Yoshida et al., J. Biol. Chem. 265(28): 17174-1...

US Patent US8796330 (2014)


BindingDB Entry DOI: 10.7270/Q22B8WQW
More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))		BDBM128069
PNG
(US8796330, 94)
Show SMILES ONC(=O)\C=C\c1ccc(NS(=O)(=O)c2ccc3ccccc3c2)cc1
Show InChI InChI=1S/C19H16N2O4S/c22-19(20-23)12-7-14-5-9-17(10-6-14)21-26(24,25)18-11-8-15-3-1-2-4-16(15)13-18/h1-13,21,23H,(H,20,22)/b12-7+
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n/an/a 30n/an/an/an/an/a37



Methylgene Inc.

US Patent


Assay Description
For deacetylase assays, 20,000 cpm of the [3H]-metabolically labeled acetylated histone substrate (M. Yoshida et al., J. Biol. Chem. 265(28): 17174-1...

US Patent US8796330 (2014)


BindingDB Entry DOI: 10.7270/Q22B8WQW
More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))		BDBM50123967
PNG
(3-[4-(Biphenyl-4-ylsulfamoyl)-phenyl]-N-hydroxy-ac...)
Show SMILES ONC(=O)\C=C\c1ccc(cc1)S(=O)(=O)Nc1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C21H18N2O4S/c24-21(22-25)15-8-16-6-13-20(14-7-16)28(26,27)23-19-11-9-18(10-12-19)17-4-2-1-3-5-17/h1-15,23,25H,(H,22,24)/b15-8+
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n/an/a 40n/an/an/an/an/a37



Methylgene Inc.

US Patent


Assay Description
For deacetylase assays, 20,000 cpm of the [3H]-metabolically labeled acetylated histone substrate (M. Yoshida et al., J. Biol. Chem. 265(28): 17174-1...

US Patent US8796330 (2014)


BindingDB Entry DOI: 10.7270/Q22B8WQW
More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))		BDBM128072
PNG
(US8796330, 101)
Show SMILES ONC(=O)\C=C\c1ccc(NS(=O)(=O)c2ccc3oc4ccccc4c3c2)cc1
Show InChI InChI=1S/C21H16N2O5S/c24-21(22-25)12-7-14-5-8-15(9-6-14)23-29(26,27)16-10-11-20-18(13-16)17-3-1-2-4-19(17)28-20/h1-13,23,25H,(H,22,24)/b12-7+
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n/an/a 40n/an/an/an/an/a37



Methylgene Inc.

US Patent


Assay Description
For deacetylase assays, 20,000 cpm of the [3H]-metabolically labeled acetylated histone substrate (M. Yoshida et al., J. Biol. Chem. 265(28): 17174-1...

US Patent US8796330 (2014)


BindingDB Entry DOI: 10.7270/Q22B8WQW
More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))		BDBM50123965
PNG
(CHEMBL353839 | N-Hydroxy-3-[4-(quinoline-8-sulfony...)
Show SMILES ONC(=O)\C=C\c1ccc(NS(=O)(=O)c2cccc3cccnc23)cc1
Show InChI InChI=1S/C18H15N3O4S/c22-17(20-23)11-8-13-6-9-15(10-7-13)21-26(24,25)16-5-1-3-14-4-2-12-19-18(14)16/h1-12,21,23H,(H,20,22)/b11-8+
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n/an/a 50n/an/an/an/an/a37



Methylgene Inc.

US Patent


Assay Description
For deacetylase assays, 20,000 cpm of the [3H]-metabolically labeled acetylated histone substrate (M. Yoshida et al., J. Biol. Chem. 265(28): 17174-1...

US Patent US8796330 (2014)


BindingDB Entry DOI: 10.7270/Q22B8WQW
More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))		BDBM50123974
PNG
(CHEMBL149534 | N-Hydroxy-3-(4-p-tolylsulfamoyl-phe...)
Show SMILES Cc1ccc(NS(=O)(=O)c2ccc(\C=C\C(=O)NO)cc2)cc1
Show InChI InChI=1S/C16H16N2O4S/c1-12-2-7-14(8-3-12)18-23(21,22)15-9-4-13(5-10-15)6-11-16(19)17-20/h2-11,18,20H,1H3,(H,17,19)/b11-6+
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n/an/a 50n/an/an/an/an/a37



Methylgene Inc.

US Patent


Assay Description
For deacetylase assays, 20,000 cpm of the [3H]-metabolically labeled acetylated histone substrate (M. Yoshida et al., J. Biol. Chem. 265(28): 17174-1...

US Patent US8796330 (2014)


BindingDB Entry DOI: 10.7270/Q22B8WQW
More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))		BDBM50123970
PNG
(CHEMBL168961 | N-Hydroxy-3-[4-(naphthalene-1-sulfo...)
Show SMILES ONC(=O)\C=C\c1ccc(NS(=O)(=O)c2cccc3ccccc23)cc1
Show InChI InChI=1S/C19H16N2O4S/c22-19(20-23)13-10-14-8-11-16(12-9-14)21-26(24,25)18-7-3-5-15-4-1-2-6-17(15)18/h1-13,21,23H,(H,20,22)/b13-10+
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n/an/a 50n/an/an/an/an/a37



Methylgene Inc.

US Patent


Assay Description
For deacetylase assays, 20,000 cpm of the [3H]-metabolically labeled acetylated histone substrate (M. Yoshida et al., J. Biol. Chem. 265(28): 17174-1...

US Patent US8796330 (2014)


BindingDB Entry DOI: 10.7270/Q22B8WQW
More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))		BDBM128073
PNG
(US8796330, 103)
Show SMILES ONC(=O)\C=C\c1ccc(NS(=O)(=O)c2ccc(s2)-c2cccs2)cc1
Show InChI InChI=1S/C17H14N2O4S3/c20-16(18-21)9-5-12-3-6-13(7-4-12)19-26(22,23)17-10-8-15(25-17)14-2-1-11-24-14/h1-11,19,21H,(H,18,20)/b9-5+
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n/an/a 50n/an/an/an/an/a37



Methylgene Inc.

US Patent


Assay Description
For deacetylase assays, 20,000 cpm of the [3H]-metabolically labeled acetylated histone substrate (M. Yoshida et al., J. Biol. Chem. 265(28): 17174-1...

US Patent US8796330 (2014)


BindingDB Entry DOI: 10.7270/Q22B8WQW
More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))		BDBM50123958
PNG
(3-[4-(3,4-Dimethoxy-phenylsulfamoyl)-phenyl]-N-hyd...)
Show SMILES COc1ccc(NS(=O)(=O)c2ccc(\C=C\C(=O)NO)cc2)cc1OC
Show InChI InChI=1S/C17H18N2O6S/c1-24-15-9-6-13(11-16(15)25-2)19-26(22,23)14-7-3-12(4-8-14)5-10-17(20)18-21/h3-11,19,21H,1-2H3,(H,18,20)/b10-5+
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n/an/a 60n/an/an/an/an/a37



Methylgene Inc.

US Patent


Assay Description
For deacetylase assays, 20,000 cpm of the [3H]-metabolically labeled acetylated histone substrate (M. Yoshida et al., J. Biol. Chem. 265(28): 17174-1...

US Patent US8796330 (2014)


BindingDB Entry DOI: 10.7270/Q22B8WQW
More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))		BDBM50105675
PNG
((E)-3-[4-(4-Chloro-benzenesulfonylamino)-phenyl]-N...)
Show SMILES ONC(=O)\C=C\c1ccc(NS(=O)(=O)c2ccc(Cl)cc2)cc1
Show InChI InChI=1S/C15H13ClN2O4S/c16-12-4-8-14(9-5-12)23(21,22)18-13-6-1-11(2-7-13)3-10-15(19)17-20/h1-10,18,20H,(H,17,19)/b10-3+
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US Patent
n/an/a 75n/an/an/an/an/a37



Methylgene Inc.

US Patent


Assay Description
For deacetylase assays, 20,000 cpm of the [3H]-metabolically labeled acetylated histone substrate (M. Yoshida et al., J. Biol. Chem. 265(28): 17174-1...

US Patent US8796330 (2014)


BindingDB Entry DOI: 10.7270/Q22B8WQW
More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))		BDBM50105689
PNG
((E)-3-[4-(3,4-Dimethoxy-benzenesulfonylamino)-phen...)
Show SMILES COc1ccc(cc1OC)S(=O)(=O)Nc1ccc(\C=C\C(=O)NO)cc1
Show InChI InChI=1S/C17H18N2O6S/c1-24-15-9-8-14(11-16(15)25-2)26(22,23)19-13-6-3-12(4-7-13)5-10-17(20)18-21/h3-11,19,21H,1-2H3,(H,18,20)/b10-5+
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n/an/a 90n/an/an/an/an/a37



Methylgene Inc.

US Patent


Assay Description
For deacetylase assays, 20,000 cpm of the [3H]-metabolically labeled acetylated histone substrate (M. Yoshida et al., J. Biol. Chem. 265(28): 17174-1...

US Patent US8796330 (2014)


BindingDB Entry DOI: 10.7270/Q22B8WQW
More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))		BDBM128075
PNG
(US8796330, 111)
Show SMILES ONC(=O)\C=C\c1ccc(NS(=O)(=O)c2cc(Cl)cc(Cl)c2O)cc1
Show InChI InChI=1S/C15H12Cl2N2O5S/c16-10-7-12(17)15(21)13(8-10)25(23,24)19-11-4-1-9(2-5-11)3-6-14(20)18-22/h1-8,19,21-22H,(H,18,20)/b6-3+
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n/an/a 95n/an/an/an/an/a37



Methylgene Inc.

US Patent


Assay Description
For deacetylase assays, 20,000 cpm of the [3H]-metabolically labeled acetylated histone substrate (M. Yoshida et al., J. Biol. Chem. 265(28): 17174-1...

US Patent US8796330 (2014)


BindingDB Entry DOI: 10.7270/Q22B8WQW
More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))		BDBM50105686
PNG
((E)-N-Hydroxy-3-[4-(toluene-3-sulfonylamino)-pheny...)
Show SMILES Cc1cccc(c1)S(=O)(=O)Nc1ccc(\C=C\C(=O)NO)cc1
Show InChI InChI=1S/C16H16N2O4S/c1-12-3-2-4-15(11-12)23(21,22)18-14-8-5-13(6-9-14)7-10-16(19)17-20/h2-11,18,20H,1H3,(H,17,19)/b10-7+
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n/an/a 100n/an/an/an/an/a37



Methylgene Inc.

US Patent


Assay Description
For deacetylase assays, 20,000 cpm of the [3H]-metabolically labeled acetylated histone substrate (M. Yoshida et al., J. Biol. Chem. 265(28): 17174-1...

US Patent US8796330 (2014)


BindingDB Entry DOI: 10.7270/Q22B8WQW
More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))		BDBM50105688
PNG
((E)-N-Hydroxy-3-[4-(3-trifluoromethyl-benzenesulfo...)
Show SMILES ONC(=O)\C=C\c1ccc(NS(=O)(=O)c2cccc(c2)C(F)(F)F)cc1
Show InChI InChI=1S/C16H13F3N2O4S/c17-16(18,19)12-2-1-3-14(10-12)26(24,25)21-13-7-4-11(5-8-13)6-9-15(22)20-23/h1-10,21,23H,(H,20,22)/b9-6+
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n/an/a 100n/an/an/an/an/a37



Methylgene Inc.

US Patent


Assay Description
For deacetylase assays, 20,000 cpm of the [3H]-metabolically labeled acetylated histone substrate (M. Yoshida et al., J. Biol. Chem. 265(28): 17174-1...

US Patent US8796330 (2014)


BindingDB Entry DOI: 10.7270/Q22B8WQW
More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))		BDBM128084
PNG
(US8796330, 149)
Show SMILES ONC(=O)c1ccc(CCCC(O)c2ccc3ccccc3c2)cc1
Show InChI InChI=1S/C21H21NO3/c23-20(19-13-12-16-5-1-2-6-18(16)14-19)7-3-4-15-8-10-17(11-9-15)21(24)22-25/h1-2,5-6,8-14,20,23,25H,3-4,7H2,(H,22,24)
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n/an/a 100n/an/an/an/an/a37



Methylgene Inc.

US Patent


Assay Description
For deacetylase assays, 20,000 cpm of the [3H]-metabolically labeled acetylated histone substrate (M. Yoshida et al., J. Biol. Chem. 265(28): 17174-1...

US Patent US8796330 (2014)


BindingDB Entry DOI: 10.7270/Q22B8WQW
More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))		BDBM50105684
PNG
(3-(4-Benzenesulfonylamino-phenyl)-N-hydroxy-propio...)
Show SMILES ONC(=O)CCc1ccc(NS(=O)(=O)c2ccccc2)cc1
Show InChI InChI=1S/C15H16N2O4S/c18-15(16-19)11-8-12-6-9-13(10-7-12)17-22(20,21)14-4-2-1-3-5-14/h1-7,9-10,17,19H,8,11H2,(H,16,18)
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n/an/a 100n/an/an/an/an/a37



Methylgene Inc.

US Patent


Assay Description
For deacetylase assays, 20,000 cpm of the [3H]-metabolically labeled acetylated histone substrate (M. Yoshida et al., J. Biol. Chem. 265(28): 17174-1...

US Patent US8796330 (2014)


BindingDB Entry DOI: 10.7270/Q22B8WQW
More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))		BDBM50105696
PNG
((E)-3-[4-(3,4-Dichloro-benzenesulfonylamino)-pheny...)
Show SMILES ONC(=O)\C=C\c1ccc(NS(=O)(=O)c2ccc(Cl)c(Cl)c2)cc1
Show InChI InChI=1S/C15H12Cl2N2O4S/c16-13-7-6-12(9-14(13)17)24(22,23)19-11-4-1-10(2-5-11)3-8-15(20)18-21/h1-9,19,21H,(H,18,20)/b8-3+
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n/an/a 120n/an/an/an/an/a37



Methylgene Inc.

US Patent


Assay Description
For deacetylase assays, 20,000 cpm of the [3H]-metabolically labeled acetylated histone substrate (M. Yoshida et al., J. Biol. Chem. 265(28): 17174-1...

US Patent US8796330 (2014)


BindingDB Entry DOI: 10.7270/Q22B8WQW
More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))		BDBM50105691
PNG
((E)-3-(4-Benzenesulfonylamino-phenyl)-N-hydroxy-ac...)
Show SMILES ONC(=O)\C=C\c1ccc(NS(=O)(=O)c2ccccc2)cc1
Show InChI InChI=1S/C15H14N2O4S/c18-15(16-19)11-8-12-6-9-13(10-7-12)17-22(20,21)14-4-2-1-3-5-14/h1-11,17,19H,(H,16,18)/b11-8+
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US Patent
n/an/a 200n/an/an/an/an/a37



Methylgene Inc.

US Patent


Assay Description
For deacetylase assays, 20,000 cpm of the [3H]-metabolically labeled acetylated histone substrate (M. Yoshida et al., J. Biol. Chem. 265(28): 17174-1...

US Patent US8796330 (2014)


BindingDB Entry DOI: 10.7270/Q22B8WQW
More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))		BDBM50105692
PNG
((E)-3-[4-(4-tert-Butyl-benzenesulfonylamino)-pheny...)
Show SMILES CC(C)(C)c1ccc(cc1)S(=O)(=O)Nc1ccc(\C=C\C(=O)NO)cc1
Show InChI InChI=1S/C19H22N2O4S/c1-19(2,3)15-7-11-17(12-8-15)26(24,25)21-16-9-4-14(5-10-16)6-13-18(22)20-23/h4-13,21,23H,1-3H3,(H,20,22)/b13-6+
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n/an/a 200n/an/an/an/an/a37



Methylgene Inc.

US Patent


Assay Description
For deacetylase assays, 20,000 cpm of the [3H]-metabolically labeled acetylated histone substrate (M. Yoshida et al., J. Biol. Chem. 265(28): 17174-1...

US Patent US8796330 (2014)


BindingDB Entry DOI: 10.7270/Q22B8WQW
More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))		BDBM128099
PNG
(US8796330, 187)
Show SMILES ONC(=O)Cc1ccc(CCCCc2ccc3OCOc3c2)cc1
Show InChI InChI=1S/C19H21NO4/c21-19(20-22)12-16-7-5-14(6-8-16)3-1-2-4-15-9-10-17-18(11-15)24-13-23-17/h5-11,22H,1-4,12-13H2,(H,20,21)
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n/an/a 200n/an/an/an/an/a37



Methylgene Inc.

US Patent


Assay Description
For deacetylase assays, 20,000 cpm of the [3H]-metabolically labeled acetylated histone substrate (M. Yoshida et al., J. Biol. Chem. 265(28): 17174-1...

US Patent US8796330 (2014)


BindingDB Entry DOI: 10.7270/Q22B8WQW
More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))		BDBM50105678
PNG
((E)-N-Hydroxy-3-[4-(4-methoxy-benzenesulfonylamino...)
Show SMILES COc1ccc(cc1)S(=O)(=O)Nc1ccc(\C=C\C(=O)NO)cc1
Show InChI InChI=1S/C16H16N2O5S/c1-23-14-7-9-15(10-8-14)24(21,22)18-13-5-2-12(3-6-13)4-11-16(19)17-20/h2-11,18,20H,1H3,(H,17,19)/b11-4+
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n/an/a 200n/an/an/an/an/a37



Methylgene Inc.

US Patent


Assay Description
For deacetylase assays, 20,000 cpm of the [3H]-metabolically labeled acetylated histone substrate (M. Yoshida et al., J. Biol. Chem. 265(28): 17174-1...

US Patent US8796330 (2014)


BindingDB Entry DOI: 10.7270/Q22B8WQW
More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))		BDBM128070
PNG
(US8796330, 95)
Show SMILES ONC(=O)\C=C\c1ccc(NS(=O)(=O)c2cc3ccccc3s2)cc1
Show InChI InChI=1S/C17H14N2O4S2/c20-16(18-21)10-7-12-5-8-14(9-6-12)19-25(22,23)17-11-13-3-1-2-4-15(13)24-17/h1-11,19,21H,(H,18,20)/b10-7+
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n/an/a 200n/an/an/an/an/a37



Methylgene Inc.

US Patent


Assay Description
For deacetylase assays, 20,000 cpm of the [3H]-metabolically labeled acetylated histone substrate (M. Yoshida et al., J. Biol. Chem. 265(28): 17174-1...

US Patent US8796330 (2014)


BindingDB Entry DOI: 10.7270/Q22B8WQW
More data for this
Ligand-Target Pair
Histone deacetylase 8


(Homo sapiens (Human))		BDBM128099
PNG
(US8796330, 187)
Show SMILES ONC(=O)Cc1ccc(CCCCc2ccc3OCOc3c2)cc1
Show InChI InChI=1S/C19H21NO4/c21-19(20-22)12-16-7-5-14(6-8-16)3-1-2-4-15-9-10-17-18(11-15)24-13-23-17/h5-11,22H,1-4,12-13H2,(H,20,21)
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n/an/a 210n/an/an/an/an/a37



Methylgene Inc.

US Patent


Assay Description
For deacetylase assays, 20,000 cpm of the [3H]-metabolically labeled acetylated histone substrate (M. Yoshida et al., J. Biol. Chem. 265(28): 17174-1...

US Patent US8796330 (2014)


BindingDB Entry DOI: 10.7270/Q22B8WQW
More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))		BDBM50123977
PNG
(3-[4-(5-Dimethylamino-naphthalene-1-sulfonylamino)...)
Show SMILES CN(C)c1cccc2c(cccc12)S(=O)(=O)Nc1ccc(\C=C\C(=O)NO)cc1
Show InChI InChI=1S/C21H21N3O4S/c1-24(2)19-7-3-6-18-17(19)5-4-8-20(18)29(27,28)23-16-12-9-15(10-13-16)11-14-21(25)22-26/h3-14,23,26H,1-2H3,(H,22,25)/b14-11+
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n/an/a 280n/an/an/an/an/a37



Methylgene Inc.

US Patent


Assay Description
For deacetylase assays, 20,000 cpm of the [3H]-metabolically labeled acetylated histone substrate (M. Yoshida et al., J. Biol. Chem. 265(28): 17174-1...

US Patent US8796330 (2014)


BindingDB Entry DOI: 10.7270/Q22B8WQW
More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))		BDBM50105677
PNG
((E)-N-Hydroxy-3-[4-(toluene-4-sulfonylamino)-pheny...)
Show SMILES Cc1ccc(cc1)S(=O)(=O)Nc1ccc(\C=C\C(=O)NO)cc1
Show InChI InChI=1S/C16H16N2O4S/c1-12-2-9-15(10-3-12)23(21,22)18-14-7-4-13(5-8-14)6-11-16(19)17-20/h2-11,18,20H,1H3,(H,17,19)/b11-6+
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n/an/a 300n/an/an/an/an/a37



Methylgene Inc.

US Patent


Assay Description
For deacetylase assays, 20,000 cpm of the [3H]-metabolically labeled acetylated histone substrate (M. Yoshida et al., J. Biol. Chem. 265(28): 17174-1...

US Patent US8796330 (2014)


BindingDB Entry DOI: 10.7270/Q22B8WQW
More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))		BDBM128077
PNG
(US8796330, 128)
Show SMILES ONC(=O)C#Cc1ccc(NS(=O)(=O)c2ccc(cc2)-c2ccccc2)cc1
Show InChI InChI=1S/C21H16N2O4S/c24-21(22-25)15-8-16-6-11-19(12-7-16)23-28(26,27)20-13-9-18(10-14-20)17-4-2-1-3-5-17/h1-7,9-14,23,25H,(H,22,24)
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n/an/a 300n/an/an/an/an/a37



Methylgene Inc.

US Patent


Assay Description
For deacetylase assays, 20,000 cpm of the [3H]-metabolically labeled acetylated histone substrate (M. Yoshida et al., J. Biol. Chem. 265(28): 17174-1...

US Patent US8796330 (2014)


BindingDB Entry DOI: 10.7270/Q22B8WQW
More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))		BDBM128065
PNG
(US8796330, 34)
Show SMILES ONC(=O)CCCCc1ccc(NS(=O)(=O)c2ccccc2)cc1
Show InChI InChI=1S/C17H20N2O4S/c20-17(18-21)9-5-4-6-14-10-12-15(13-11-14)19-24(22,23)16-7-2-1-3-8-16/h1-3,7-8,10-13,19,21H,4-6,9H2,(H,18,20)
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n/an/a 300n/an/an/an/an/a37



Methylgene Inc.

US Patent


Assay Description
For deacetylase assays, 20,000 cpm of the [3H]-metabolically labeled acetylated histone substrate (M. Yoshida et al., J. Biol. Chem. 265(28): 17174-1...

US Patent US8796330 (2014)


BindingDB Entry DOI: 10.7270/Q22B8WQW
More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))		BDBM50105681
PNG
((E)-3-[4-(2,4-Dichloro-benzenesulfonylamino)-pheny...)
Show SMILES ONC(=O)\C=C\c1ccc(NS(=O)(=O)c2ccc(Cl)cc2Cl)cc1
Show InChI InChI=1S/C15H12Cl2N2O4S/c16-11-4-7-14(13(17)9-11)24(22,23)19-12-5-1-10(2-6-12)3-8-15(20)18-21/h1-9,19,21H,(H,18,20)/b8-3+
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n/an/a 300n/an/an/an/an/a37



Methylgene Inc.

US Patent


Assay Description
For deacetylase assays, 20,000 cpm of the [3H]-metabolically labeled acetylated histone substrate (M. Yoshida et al., J. Biol. Chem. 265(28): 17174-1...

US Patent US8796330 (2014)


BindingDB Entry DOI: 10.7270/Q22B8WQW
More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))		BDBM128096
PNG
(US8796330, 183)
Show SMILES ONC(=O)Cc1ccc(CCCCc2ccc3[nH]ccc3c2)cc1
Show InChI InChI=1S/C20H22N2O2/c23-20(22-24)14-17-7-5-15(6-8-17)3-1-2-4-16-9-10-19-18(13-16)11-12-21-19/h5-13,21,24H,1-4,14H2,(H,22,23)
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n/an/a 380n/an/an/an/an/a37



Methylgene Inc.

US Patent


Assay Description
For deacetylase assays, 20,000 cpm of the [3H]-metabolically labeled acetylated histone substrate (M. Yoshida et al., J. Biol. Chem. 265(28): 17174-1...

US Patent US8796330 (2014)


BindingDB Entry DOI: 10.7270/Q22B8WQW
More data for this
Ligand-Target Pair
Histone deacetylase 8


(Homo sapiens (Human))		BDBM128097
PNG
(US8796330, 184)
Show SMILES ONC(=O)Cc1ccc(CCCCc2cccc(c2)C(F)(F)F)cc1
Show InChI InChI=1S/C19H20F3NO2/c20-19(21,22)17-7-3-6-15(12-17)5-2-1-4-14-8-10-16(11-9-14)13-18(24)23-25/h3,6-12,25H,1-2,4-5,13H2,(H,23,24)
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n/an/a 400n/an/an/an/an/a37



Methylgene Inc.

US Patent


Assay Description
For deacetylase assays, 20,000 cpm of the [3H]-metabolically labeled acetylated histone substrate (M. Yoshida et al., J. Biol. Chem. 265(28): 17174-1...

US Patent US8796330 (2014)


BindingDB Entry DOI: 10.7270/Q22B8WQW
More data for this
Ligand-Target Pair
Histone deacetylase 8


(Homo sapiens (Human))		BDBM128096
PNG
(US8796330, 183)
Show SMILES ONC(=O)Cc1ccc(CCCCc2ccc3[nH]ccc3c2)cc1
Show InChI InChI=1S/C20H22N2O2/c23-20(22-24)14-17-7-5-15(6-8-17)3-1-2-4-16-9-10-19-18(13-16)11-12-21-19/h5-13,21,24H,1-4,14H2,(H,22,23)
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n/an/a 410n/an/an/an/an/a37



Methylgene Inc.

US Patent


Assay Description
For deacetylase assays, 20,000 cpm of the [3H]-metabolically labeled acetylated histone substrate (M. Yoshida et al., J. Biol. Chem. 265(28): 17174-1...

US Patent US8796330 (2014)


BindingDB Entry DOI: 10.7270/Q22B8WQW
More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))		BDBM50123973
PNG
(3-{4-[3-(3,4-Dimethoxy-phenyl)-ureido]-phenyl}-N-h...)
Show SMILES COc1ccc(NC(=O)Nc2ccc(\C=C\C(=O)NO)cc2)cc1OC
Show InChI InChI=1S/C18H19N3O5/c1-25-15-9-8-14(11-16(15)26-2)20-18(23)19-13-6-3-12(4-7-13)5-10-17(22)21-24/h3-11,24H,1-2H3,(H,21,22)(H2,19,20,23)/b10-5+
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n/an/a 480n/an/an/an/an/a37



Methylgene Inc.

US Patent


Assay Description
For deacetylase assays, 20,000 cpm of the [3H]-metabolically labeled acetylated histone substrate (M. Yoshida et al., J. Biol. Chem. 265(28): 17174-1...

US Patent US8796330 (2014)


BindingDB Entry DOI: 10.7270/Q22B8WQW
More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))		BDBM128095
PNG
(US8796330, 179)
Show SMILES ONC(=O)Cc1ccc(CCCCc2cc(F)c(F)cc2F)cc1
Show InChI InChI=1S/C18H18F3NO2/c19-15-11-17(21)16(20)10-14(15)4-2-1-3-12-5-7-13(8-6-12)9-18(23)22-24/h5-8,10-11,24H,1-4,9H2,(H,22,23)
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n/an/a 500n/an/an/an/an/a37



Methylgene Inc.

US Patent


Assay Description
For deacetylase assays, 20,000 cpm of the [3H]-metabolically labeled acetylated histone substrate (M. Yoshida et al., J. Biol. Chem. 265(28): 17174-1...

US Patent US8796330 (2014)


BindingDB Entry DOI: 10.7270/Q22B8WQW
More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))		BDBM128078
PNG
(US8796330, 136)
Show SMILES ONC(=O)\C=C\c1ccc(CC(O)c2ccccc2)o1
Show InChI InChI=1S/C15H15NO4/c17-14(11-4-2-1-3-5-11)10-13-7-6-12(20-13)8-9-15(18)16-19/h1-9,14,17,19H,10H2,(H,16,18)/b9-8+
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n/an/a 500n/an/an/an/an/a37



Methylgene Inc.

US Patent


Assay Description
For deacetylase assays, 20,000 cpm of the [3H]-metabolically labeled acetylated histone substrate (M. Yoshida et al., J. Biol. Chem. 265(28): 17174-1...

US Patent US8796330 (2014)


BindingDB Entry DOI: 10.7270/Q22B8WQW
More data for this
Ligand-Target Pair
Histone deacetylase 8


(Homo sapiens (Human))		BDBM128095
PNG
(US8796330, 179)
Show SMILES ONC(=O)Cc1ccc(CCCCc2cc(F)c(F)cc2F)cc1
Show InChI InChI=1S/C18H18F3NO2/c19-15-11-17(21)16(20)10-14(15)4-2-1-3-12-5-7-13(8-6-12)9-18(23)22-24/h5-8,10-11,24H,1-4,9H2,(H,22,23)
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n/an/a 530n/an/an/an/an/a37



Methylgene Inc.

US Patent


Assay Description
For deacetylase assays, 20,000 cpm of the [3H]-metabolically labeled acetylated histone substrate (M. Yoshida et al., J. Biol. Chem. 265(28): 17174-1...

US Patent US8796330 (2014)


BindingDB Entry DOI: 10.7270/Q22B8WQW
More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))		BDBM128074
PNG
(US8796330, 110)
Show SMILES CC(C)c1cc(C(C)C)c(c(c1)C(C)C)S(=O)(=O)Nc1ccc(\C=C\C(=O)NO)cc1
Show InChI InChI=1S/C24H32N2O4S/c1-15(2)19-13-21(16(3)4)24(22(14-19)17(5)6)31(29,30)26-20-10-7-18(8-11-20)9-12-23(27)25-28/h7-17,26,28H,1-6H3,(H,25,27)/b12-9+
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n/an/a 550n/an/an/an/an/a37



Methylgene Inc.

US Patent


Assay Description
For deacetylase assays, 20,000 cpm of the [3H]-metabolically labeled acetylated histone substrate (M. Yoshida et al., J. Biol. Chem. 265(28): 17174-1...

US Patent US8796330 (2014)


BindingDB Entry DOI: 10.7270/Q22B8WQW
More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))		BDBM50105685
PNG
((E)-3-[4-(Benzenesulfonyl-methyl-amino)-phenyl]-N-...)
Show SMILES CN(c1ccc(\C=C\C(=O)NO)cc1)S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C16H16N2O4S/c1-18(23(21,22)15-5-3-2-4-6-15)14-10-7-13(8-11-14)9-12-16(19)17-20/h2-12,20H,1H3,(H,17,19)/b12-9+
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n/an/a 570n/an/an/an/an/a37



Methylgene Inc.

US Patent


Assay Description
For deacetylase assays, 20,000 cpm of the [3H]-metabolically labeled acetylated histone substrate (M. Yoshida et al., J. Biol. Chem. 265(28): 17174-1...

US Patent US8796330 (2014)


BindingDB Entry DOI: 10.7270/Q22B8WQW
More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))		BDBM50105683
PNG
((E)-N-Hydroxy-3-[4-(4-trifluoromethoxy-benzenesulf...)
Show SMILES ONC(=O)\C=C\c1ccc(NS(=O)(=O)c2ccc(OC(F)(F)F)cc2)cc1
Show InChI InChI=1S/C16H13F3N2O5S/c17-16(18,19)26-13-6-8-14(9-7-13)27(24,25)21-12-4-1-11(2-5-12)3-10-15(22)20-23/h1-10,21,23H,(H,20,22)/b10-3+
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n/an/a 600n/an/an/an/an/a37



Methylgene Inc.

US Patent


Assay Description
For deacetylase assays, 20,000 cpm of the [3H]-metabolically labeled acetylated histone substrate (M. Yoshida et al., J. Biol. Chem. 265(28): 17174-1...

US Patent US8796330 (2014)


BindingDB Entry DOI: 10.7270/Q22B8WQW
More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))		BDBM128068
PNG
(US8796330, 87)
Show SMILES ONC(=O)\C=C\c1ccc(NS(=O)(=O)c2cccs2)cc1
Show InChI InChI=1S/C13H12N2O4S2/c16-12(14-17)8-5-10-3-6-11(7-4-10)15-21(18,19)13-2-1-9-20-13/h1-9,15,17H,(H,14,16)/b8-5+
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n/an/a 600n/an/an/an/an/a37



Methylgene Inc.

US Patent


Assay Description
For deacetylase assays, 20,000 cpm of the [3H]-metabolically labeled acetylated histone substrate (M. Yoshida et al., J. Biol. Chem. 265(28): 17174-1...

US Patent US8796330 (2014)


BindingDB Entry DOI: 10.7270/Q22B8WQW
More data for this
Ligand-Target Pair
Histone deacetylase 8


(Homo sapiens (Human))		BDBM128098
PNG
(US8796330, 185)
Show SMILES ONC(=O)Cc1ccc(CCCCc2ccccc2C(F)(F)F)cc1
Show InChI InChI=1S/C19H20F3NO2/c20-19(21,22)17-8-4-3-7-16(17)6-2-1-5-14-9-11-15(12-10-14)13-18(24)23-25/h3-4,7-12,25H,1-2,5-6,13H2,(H,23,24)
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n/an/a 610n/an/an/an/an/a37



Methylgene Inc.

US Patent


Assay Description
For deacetylase assays, 20,000 cpm of the [3H]-metabolically labeled acetylated histone substrate (M. Yoshida et al., J. Biol. Chem. 265(28): 17174-1...

US Patent US8796330 (2014)


BindingDB Entry DOI: 10.7270/Q22B8WQW
More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))		BDBM128067
PNG
(US8796330, 77)
Show SMILES ONC(=O)CCc1ccc(CCCc2ccccc2)cc1
Show InChI InChI=1S/C18H21NO2/c20-18(19-21)14-13-17-11-9-16(10-12-17)8-4-7-15-5-2-1-3-6-15/h1-3,5-6,9-12,21H,4,7-8,13-14H2,(H,19,20)
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n/an/a 650n/an/an/an/an/a37



Methylgene Inc.

US Patent


Assay Description
For deacetylase assays, 20,000 cpm of the [3H]-metabolically labeled acetylated histone substrate (M. Yoshida et al., J. Biol. Chem. 265(28): 17174-1...

US Patent US8796330 (2014)


BindingDB Entry DOI: 10.7270/Q22B8WQW
More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))		BDBM128100
PNG
(US8796330, 182)
Show SMILES ONC(=O)Cc1ccc(CCCCc2ccc(cc2)C(F)(F)F)cc1
Show InChI InChI=1S/C19H20F3NO2/c20-19(21,22)17-11-9-15(10-12-17)4-2-1-3-14-5-7-16(8-6-14)13-18(24)23-25/h5-12,25H,1-4,13H2,(H,23,24)
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n/an/a 700n/an/an/an/an/a37



Methylgene Inc.

US Patent


Assay Description
For deacetylase assays, 20,000 cpm of the [3H]-metabolically labeled acetylated histone substrate (M. Yoshida et al., J. Biol. Chem. 265(28): 17174-1...

US Patent US8796330 (2014)


BindingDB Entry DOI: 10.7270/Q22B8WQW
More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))		BDBM128071
PNG
(US8796330, 100)
Show SMILES ONC(=O)\C=C\c1ccc(NS(=O)(=O)Cc2ccccc2)cc1
Show InChI InChI=1S/C16H16N2O4S/c19-16(17-20)11-8-13-6-9-15(10-7-13)18-23(21,22)12-14-4-2-1-3-5-14/h1-11,18,20H,12H2,(H,17,19)/b11-8+
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n/an/a 750n/an/an/an/an/a37



Methylgene Inc.

US Patent


Assay Description
For deacetylase assays, 20,000 cpm of the [3H]-metabolically labeled acetylated histone substrate (M. Yoshida et al., J. Biol. Chem. 265(28): 17174-1...

US Patent US8796330 (2014)


BindingDB Entry DOI: 10.7270/Q22B8WQW
More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))		BDBM128089
PNG
(US8796330, 156)
Show SMILES ONC(=O)CCCc1ccc(CCCCc2ccccc2)cc1
Show InChI InChI=1S/C20H25NO2/c22-20(21-23)12-6-11-19-15-13-18(14-16-19)10-5-4-9-17-7-2-1-3-8-17/h1-3,7-8,13-16,23H,4-6,9-12H2,(H,21,22)
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n/an/a 750n/an/an/an/an/a37



Methylgene Inc.

US Patent


Assay Description
For deacetylase assays, 20,000 cpm of the [3H]-metabolically labeled acetylated histone substrate (M. Yoshida et al., J. Biol. Chem. 265(28): 17174-1...

US Patent US8796330 (2014)


BindingDB Entry DOI: 10.7270/Q22B8WQW
More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))		BDBM50105693
PNG
((E)-N-Hydroxy-3-[4-(4-sulfamoyl-benzenesulfonylami...)
Show SMILES NS(=O)(=O)c1ccc(cc1)S(=O)(=O)Nc1ccc(\C=C\C(=O)NO)cc1
Show InChI InChI=1S/C15H15N3O6S2/c16-25(21,22)13-6-8-14(9-7-13)26(23,24)18-12-4-1-11(2-5-12)3-10-15(19)17-20/h1-10,18,20H,(H,17,19)(H2,16,21,22)/b10-3+
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n/an/a 800n/an/an/an/an/a37



Methylgene Inc.

US Patent


Assay Description
For deacetylase assays, 20,000 cpm of the [3H]-metabolically labeled acetylated histone substrate (M. Yoshida et al., J. Biol. Chem. 265(28): 17174-1...

US Patent US8796330 (2014)


BindingDB Entry DOI: 10.7270/Q22B8WQW
More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))		BDBM128098
PNG
(US8796330, 185)
Show SMILES ONC(=O)Cc1ccc(CCCCc2ccccc2C(F)(F)F)cc1
Show InChI InChI=1S/C19H20F3NO2/c20-19(21,22)17-8-4-3-7-16(17)6-2-1-5-14-9-11-15(12-10-14)13-18(24)23-25/h3-4,7-12,25H,1-2,5-6,13H2,(H,23,24)
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n/an/a 840n/an/an/an/an/a37



Methylgene Inc.

US Patent


Assay Description
For deacetylase assays, 20,000 cpm of the [3H]-metabolically labeled acetylated histone substrate (M. Yoshida et al., J. Biol. Chem. 265(28): 17174-1...

US Patent US8796330 (2014)


BindingDB Entry DOI: 10.7270/Q22B8WQW
More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))		BDBM128081
PNG
(US8796330, 145)
Show SMILES ONC(=O)\C=C\c1ccc(NC(=O)Nc2ccc(Cl)cc2)cc1
Show InChI InChI=1S/C16H14ClN3O3/c17-12-4-8-14(9-5-12)19-16(22)18-13-6-1-11(2-7-13)3-10-15(21)20-23/h1-10,23H,(H,20,21)(H2,18,19,22)/b10-3+
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n/an/a 840n/an/an/an/an/a37



Methylgene Inc.

US Patent


Assay Description
For deacetylase assays, 20,000 cpm of the [3H]-metabolically labeled acetylated histone substrate (M. Yoshida et al., J. Biol. Chem. 265(28): 17174-1...

US Patent US8796330 (2014)


BindingDB Entry DOI: 10.7270/Q22B8WQW
More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))		BDBM128066
PNG
(US8796330, 70)
Show SMILES ONC(=O)c1ccc(CCSc2ccccc2)cc1
Show InChI InChI=1S/C15H15NO2S/c17-15(16-18)13-8-6-12(7-9-13)10-11-19-14-4-2-1-3-5-14/h1-9,18H,10-11H2,(H,16,17)
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n/an/a 900n/an/an/an/an/a37



Methylgene Inc.

US Patent


Assay Description
For deacetylase assays, 20,000 cpm of the [3H]-metabolically labeled acetylated histone substrate (M. Yoshida et al., J. Biol. Chem. 265(28): 17174-1...

US Patent US8796330 (2014)


BindingDB Entry DOI: 10.7270/Q22B8WQW
More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))		BDBM50105679
PNG
((E)-N-Hydroxy-3-[4-(4-nitro-benzenesulfonylamino)-...)
Show SMILES ONC(=O)\C=C\c1ccc(NS(=O)(=O)c2ccc(cc2)[N+]([O-])=O)cc1
Show InChI InChI=1S/C15H13N3O6S/c19-15(16-20)10-3-11-1-4-12(5-2-11)17-25(23,24)14-8-6-13(7-9-14)18(21)22/h1-10,17,20H,(H,16,19)/b10-3+
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n/an/a 900n/an/an/an/an/a37



Methylgene Inc.

US Patent


Assay Description
For deacetylase assays, 20,000 cpm of the [3H]-metabolically labeled acetylated histone substrate (M. Yoshida et al., J. Biol. Chem. 265(28): 17174-1...

US Patent US8796330 (2014)


BindingDB Entry DOI: 10.7270/Q22B8WQW
More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))		BDBM128088
PNG
(US8796330, 154)
Show SMILES ONC(=O)CCc1ccc(CCCCc2ccccc2)cc1
Show InChI InChI=1S/C19H23NO2/c21-19(20-22)15-14-18-12-10-17(11-13-18)9-5-4-8-16-6-2-1-3-7-16/h1-3,6-7,10-13,22H,4-5,8-9,14-15H2,(H,20,21)
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n/an/a 900n/an/an/an/an/a37



Methylgene Inc.

US Patent


Assay Description
For deacetylase assays, 20,000 cpm of the [3H]-metabolically labeled acetylated histone substrate (M. Yoshida et al., J. Biol. Chem. 265(28): 17174-1...

US Patent US8796330 (2014)


BindingDB Entry DOI: 10.7270/Q22B8WQW
More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))		BDBM128082
PNG
(US8796330, 146)
Show SMILES ONC(=O)\C=C\c1ccc(NC(=O)Nc2cccc3ccccc23)cc1
Show InChI InChI=1S/C20H17N3O3/c24-19(23-26)13-10-14-8-11-16(12-9-14)21-20(25)22-18-7-3-5-15-4-1-2-6-17(15)18/h1-13,26H,(H,23,24)(H2,21,22,25)/b13-10+
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n/an/a 910n/an/an/an/an/a37



Methylgene Inc.

US Patent


Assay Description
For deacetylase assays, 20,000 cpm of the [3H]-metabolically labeled acetylated histone substrate (M. Yoshida et al., J. Biol. Chem. 265(28): 17174-1...

US Patent US8796330 (2014)


BindingDB Entry DOI: 10.7270/Q22B8WQW
More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))		BDBM128097
PNG
(US8796330, 184)
Show SMILES ONC(=O)Cc1ccc(CCCCc2cccc(c2)C(F)(F)F)cc1
Show InChI InChI=1S/C19H20F3NO2/c20-19(21,22)17-7-3-6-15(12-17)5-2-1-4-14-8-10-16(11-9-14)13-18(24)23-25/h3,6-12,25H,1-2,4-5,13H2,(H,23,24)
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n/an/a 930n/an/an/an/an/a37



Methylgene Inc.

US Patent


Assay Description
For deacetylase assays, 20,000 cpm of the [3H]-metabolically labeled acetylated histone substrate (M. Yoshida et al., J. Biol. Chem. 265(28): 17174-1...

US Patent US8796330 (2014)


BindingDB Entry DOI: 10.7270/Q22B8WQW
More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))		BDBM50105694
PNG
(4-(4-Benzenesulfonylamino-phenyl)-N-hydroxy-butyra...)
Show SMILES ONC(=O)CCCc1ccc(NS(=O)(=O)c2ccccc2)cc1
Show InChI InChI=1S/C16H18N2O4S/c19-16(17-20)8-4-5-13-9-11-14(12-10-13)18-23(21,22)15-6-2-1-3-7-15/h1-3,6-7,9-12,18,20H,4-5,8H2,(H,17,19)
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n/an/a 1.00E+3n/an/an/an/an/a37



Methylgene Inc.

US Patent


Assay Description
For deacetylase assays, 20,000 cpm of the [3H]-metabolically labeled acetylated histone substrate (M. Yoshida et al., J. Biol. Chem. 265(28): 17174-1...

US Patent US8796330 (2014)


BindingDB Entry DOI: 10.7270/Q22B8WQW
More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))		BDBM128085
PNG
(US8796330, 150)
Show SMILES ONC(=O)c1ccc(CCc2ccccc2)cc1
Show InChI InChI=1S/C15H15NO2/c17-15(16-18)14-10-8-13(9-11-14)7-6-12-4-2-1-3-5-12/h1-5,8-11,18H,6-7H2,(H,16,17)
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n/an/a 1.00E+3n/an/an/an/an/a37



Methylgene Inc.

US Patent


Assay Description
For deacetylase assays, 20,000 cpm of the [3H]-metabolically labeled acetylated histone substrate (M. Yoshida et al., J. Biol. Chem. 265(28): 17174-1...

US Patent US8796330 (2014)


BindingDB Entry DOI: 10.7270/Q22B8WQW
More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))		BDBM50123964
PNG
((E)-N-(2-Amino-phenyl)-3-[4-(biphenyl-4-sulfonylam...)
Show SMILES Nc1ccccc1NC(=O)\C=C\c1ccc(NS(=O)(=O)c2ccc(cc2)-c2ccccc2)cc1
Show InChI InChI=1S/C27H23N3O3S/c28-25-8-4-5-9-26(25)29-27(31)19-12-20-10-15-23(16-11-20)30-34(32,33)24-17-13-22(14-18-24)21-6-2-1-3-7-21/h1-19,30H,28H2,(H,29,31)/b19-12+
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n/an/a 1.00E+3n/an/an/an/an/a37



Methylgene Inc.

US Patent


Assay Description
For deacetylase assays, 20,000 cpm of the [3H]-metabolically labeled acetylated histone substrate (M. Yoshida et al., J. Biol. Chem. 265(28): 17174-1...

US Patent US8796330 (2014)


BindingDB Entry DOI: 10.7270/Q22B8WQW
More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))		BDBM50123966
PNG
((E)-N-(2-Amino-phenyl)-3-[4-(biphenyl-4-ylsulfamoy...)
Show SMILES Nc1ccccc1NC(=O)\C=C\c1ccc(cc1)S(=O)(=O)Nc1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C27H23N3O3S/c28-25-8-4-5-9-26(25)29-27(31)19-12-20-10-17-24(18-11-20)34(32,33)30-23-15-13-22(14-16-23)21-6-2-1-3-7-21/h1-19,30H,28H2,(H,29,31)/b19-12+
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n/an/a 1.20E+3n/an/an/an/an/a37



Methylgene Inc.

US Patent


Assay Description
For deacetylase assays, 20,000 cpm of the [3H]-metabolically labeled acetylated histone substrate (M. Yoshida et al., J. Biol. Chem. 265(28): 17174-1...

US Patent US8796330 (2014)


BindingDB Entry DOI: 10.7270/Q22B8WQW
More data for this
Ligand-Target Pair
Histone deacetylase 8


(Homo sapiens (Human))		BDBM128100
PNG
(US8796330, 182)
Show SMILES ONC(=O)Cc1ccc(CCCCc2ccc(cc2)C(F)(F)F)cc1
Show InChI InChI=1S/C19H20F3NO2/c20-19(21,22)17-11-9-15(10-12-17)4-2-1-3-14-5-7-16(8-6-14)13-18(24)23-25/h5-12,25H,1-4,13H2,(H,23,24)
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n/an/a 1.30E+3n/an/an/an/an/a37



Methylgene Inc.

US Patent


Assay Description
For deacetylase assays, 20,000 cpm of the [3H]-metabolically labeled acetylated histone substrate (M. Yoshida et al., J. Biol. Chem. 265(28): 17174-1...

US Patent US8796330 (2014)


BindingDB Entry DOI: 10.7270/Q22B8WQW
More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))		BDBM50123959
PNG
((E)-N-(2-Amino-phenyl)-3-(4-p-tolylsulfamoyl-pheny...)
Show SMILES Cc1ccc(NS(=O)(=O)c2ccc(\C=C\C(=O)Nc3ccccc3N)cc2)cc1
Show InChI InChI=1S/C22H21N3O3S/c1-16-6-11-18(12-7-16)25-29(27,28)19-13-8-17(9-14-19)10-15-22(26)24-21-5-3-2-4-20(21)23/h2-15,25H,23H2,1H3,(H,24,26)/b15-10+
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n/an/a 1.50E+3n/an/an/an/an/a37



Methylgene Inc.

US Patent


Assay Description
For deacetylase assays, 20,000 cpm of the [3H]-metabolically labeled acetylated histone substrate (M. Yoshida et al., J. Biol. Chem. 265(28): 17174-1...

US Patent US8796330 (2014)


BindingDB Entry DOI: 10.7270/Q22B8WQW
More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))		BDBM50123952
PNG
(CHEMBL353629 | N-(2-Amino-phenyl)-3-[4-(4-tert-but...)
Show SMILES CC(C)(C)c1ccc(cc1)S(=O)(=O)Nc1ccc(\C=C\C(=O)Nc2ccccc2N)cc1
Show InChI InChI=1S/C25H27N3O3S/c1-25(2,3)19-11-15-21(16-12-19)32(30,31)28-20-13-8-18(9-14-20)10-17-24(29)27-23-7-5-4-6-22(23)26/h4-17,28H,26H2,1-3H3,(H,27,29)/b17-10+
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n/an/a 1.90E+3n/an/an/an/an/a37



Methylgene Inc.

US Patent


Assay Description
For deacetylase assays, 20,000 cpm of the [3H]-metabolically labeled acetylated histone substrate (M. Yoshida et al., J. Biol. Chem. 265(28): 17174-1...

US Patent US8796330 (2014)


BindingDB Entry DOI: 10.7270/Q22B8WQW
More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))		BDBM50105695
PNG
((E)-3-(4-Benzenesulfonylamino-phenyl)-N-hydroxy-2-...)
Show SMILES C\C(=C/c1ccc(NS(=O)(=O)c2ccccc2)cc1)C(=O)NO
Show InChI InChI=1S/C16H16N2O4S/c1-12(16(19)17-20)11-13-7-9-14(10-8-13)18-23(21,22)15-5-3-2-4-6-15/h2-11,18,20H,1H3,(H,17,19)/b12-11+
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n/an/a 2.00E+3n/an/an/an/an/a37



Methylgene Inc.

US Patent


Assay Description
For deacetylase assays, 20,000 cpm of the [3H]-metabolically labeled acetylated histone substrate (M. Yoshida et al., J. Biol. Chem. 265(28): 17174-1...

US Patent US8796330 (2014)


BindingDB Entry DOI: 10.7270/Q22B8WQW
More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))		BDBM128083
PNG
(US8796330, 148)
Show SMILES ONC(=O)c1ccc(CCCS(=O)(=O)c2ccccc2)cc1
Show InChI InChI=1S/C16H17NO4S/c18-16(17-19)14-10-8-13(9-11-14)5-4-12-22(20,21)15-6-2-1-3-7-15/h1-3,6-11,19H,4-5,12H2,(H,17,18)
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n/an/a 2.00E+3n/an/an/an/an/a37



Methylgene Inc.

US Patent


Assay Description
For deacetylase assays, 20,000 cpm of the [3H]-metabolically labeled acetylated histone substrate (M. Yoshida et al., J. Biol. Chem. 265(28): 17174-1...

US Patent US8796330 (2014)


BindingDB Entry DOI: 10.7270/Q22B8WQW
More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))		BDBM128092
PNG
(US8796330, 165)
Show SMILES Sc1nnc(NC(=O)C=Cc2ccc(NS(=O)(=O)c3ccc(cc3)-c3ccccc3)cc2)s1 |w:9.9|
Show InChI InChI=1S/C23H18N4O3S3/c28-21(24-22-25-26-23(31)32-22)15-8-16-6-11-19(12-7-16)27-33(29,30)20-13-9-18(10-14-20)17-4-2-1-3-5-17/h1-15,27H,(H,26,31)(H,24,25,28)
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n/an/a 2.00E+3n/an/an/an/an/a37



Methylgene Inc.

US Patent


Assay Description
For deacetylase assays, 20,000 cpm of the [3H]-metabolically labeled acetylated histone substrate (M. Yoshida et al., J. Biol. Chem. 265(28): 17174-1...

US Patent US8796330 (2014)


BindingDB Entry DOI: 10.7270/Q22B8WQW
More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))		BDBM128086
PNG
(US8796330, 151)
Show SMILES ONC(=O)c1ccc(\C=C\c2ccccc2)cc1
Show InChI InChI=1S/C15H13NO2/c17-15(16-18)14-10-8-13(9-11-14)7-6-12-4-2-1-3-5-12/h1-11,18H,(H,16,17)/b7-6+
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n/an/a 2.30E+3n/an/an/an/an/a37



Methylgene Inc.

US Patent


Assay Description
For deacetylase assays, 20,000 cpm of the [3H]-metabolically labeled acetylated histone substrate (M. Yoshida et al., J. Biol. Chem. 265(28): 17174-1...

US Patent US8796330 (2014)


BindingDB Entry DOI: 10.7270/Q22B8WQW
More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))		BDBM50123953
PNG
(CHEMBL353658 | N-(2-Amino-phenyl)-3-[4-(4-methoxy-...)
Show SMILES COc1ccc(cc1)S(=O)(=O)Nc1ccc(\C=C\C(=O)Nc2ccccc2N)cc1
Show InChI InChI=1S/C22H21N3O4S/c1-29-18-11-13-19(14-12-18)30(27,28)25-17-9-6-16(7-10-17)8-15-22(26)24-21-5-3-2-4-20(21)23/h2-15,25H,23H2,1H3,(H,24,26)/b15-8+
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n/an/a 2.30E+3n/an/an/an/an/a37



Methylgene Inc.

US Patent


Assay Description
For deacetylase assays, 20,000 cpm of the [3H]-metabolically labeled acetylated histone substrate (M. Yoshida et al., J. Biol. Chem. 265(28): 17174-1...

US Patent US8796330 (2014)


BindingDB Entry DOI: 10.7270/Q22B8WQW
More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))		BDBM50123954
PNG
((E)-N-(2-Amino-phenyl)-3-[4-(3,4-dimethoxy-phenyls...)
Show SMILES COc1ccc(NS(=O)(=O)c2ccc(\C=C\C(=O)Nc3ccccc3N)cc2)cc1OC
Show InChI InChI=1S/C23H23N3O5S/c1-30-21-13-10-17(15-22(21)31-2)26-32(28,29)18-11-7-16(8-12-18)9-14-23(27)25-20-6-4-3-5-19(20)24/h3-15,26H,24H2,1-2H3,(H,25,27)/b14-9+
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n/an/a 2.30E+3n/an/an/an/an/a37



Methylgene Inc.

US Patent


Assay Description
For deacetylase assays, 20,000 cpm of the [3H]-metabolically labeled acetylated histone substrate (M. Yoshida et al., J. Biol. Chem. 265(28): 17174-1...

US Patent US8796330 (2014)


BindingDB Entry DOI: 10.7270/Q22B8WQW
More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))		BDBM128090
PNG
(US8796330, 157)
Show SMILES ONC(=O)CCc1ccc(CCc2ccccc2)cc1
Show InChI InChI=1S/C17H19NO2/c19-17(18-20)13-12-16-10-8-15(9-11-16)7-6-14-4-2-1-3-5-14/h1-5,8-11,20H,6-7,12-13H2,(H,18,19)
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n/an/a 2.40E+3n/an/an/an/an/a37



Methylgene Inc.

US Patent


Assay Description
For deacetylase assays, 20,000 cpm of the [3H]-metabolically labeled acetylated histone substrate (M. Yoshida et al., J. Biol. Chem. 265(28): 17174-1...

US Patent US8796330 (2014)


BindingDB Entry DOI: 10.7270/Q22B8WQW
More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))		BDBM128079
PNG
(US8796330, 143)
Show SMILES ONC(=O)CCc1ccc(CC(=O)c2ccccc2)o1
Show InChI InChI=1S/C15H15NO4/c17-14(11-4-2-1-3-5-11)10-13-7-6-12(20-13)8-9-15(18)16-19/h1-7,19H,8-10H2,(H,16,18)
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n/an/a 2.40E+3n/an/an/an/an/a37



Methylgene Inc.

US Patent


Assay Description
For deacetylase assays, 20,000 cpm of the [3H]-metabolically labeled acetylated histone substrate (M. Yoshida et al., J. Biol. Chem. 265(28): 17174-1...

US Patent US8796330 (2014)


BindingDB Entry DOI: 10.7270/Q22B8WQW
More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))		BDBM50123961
PNG
((E)-N-(2-Amino-phenyl)-3-[4-(toluene-4-sulfonylami...)
Show SMILES Cc1ccc(cc1)S(=O)(=O)Nc1ccc(\C=C\C(=O)Nc2ccccc2N)cc1
Show InChI InChI=1S/C22H21N3O3S/c1-16-6-13-19(14-7-16)29(27,28)25-18-11-8-17(9-12-18)10-15-22(26)24-21-5-3-2-4-20(21)23/h2-15,25H,23H2,1H3,(H,24,26)/b15-10+
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n/an/a 3.00E+3n/an/an/an/an/a37



Methylgene Inc.

US Patent


Assay Description
For deacetylase assays, 20,000 cpm of the [3H]-metabolically labeled acetylated histone substrate (M. Yoshida et al., J. Biol. Chem. 265(28): 17174-1...

US Patent US8796330 (2014)


BindingDB Entry DOI: 10.7270/Q22B8WQW
More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))		BDBM128093
PNG
(US8796330, 168)
Show SMILES Nc1ccccc1NC(=O)\C=C\C#Cc1cccc(NS(=O)(=O)c2ccccc2)c1
Show InChI InChI=1S/C23H19N3O3S/c24-21-14-5-6-15-22(21)25-23(27)16-7-4-9-18-10-8-11-19(17-18)26-30(28,29)20-12-2-1-3-13-20/h1-3,5-8,10-17,26H,24H2,(H,25,27)/b16-7+
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n/an/a 3.00E+3n/an/an/an/an/a37



Methylgene Inc.

US Patent


Assay Description
For deacetylase assays, 20,000 cpm of the [3H]-metabolically labeled acetylated histone substrate (M. Yoshida et al., J. Biol. Chem. 265(28): 17174-1...

US Patent US8796330 (2014)


BindingDB Entry DOI: 10.7270/Q22B8WQW
More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))		BDBM50123963
PNG
(3-[4-(Biphenyl-4-sulfonylamino)-phenyl]-propynoic ...)
Show SMILES Nc1ccccc1NC(=O)C#Cc1ccc(NS(=O)(=O)c2ccc(cc2)-c2ccccc2)cc1
Show InChI InChI=1S/C27H21N3O3S/c28-25-8-4-5-9-26(25)29-27(31)19-12-20-10-15-23(16-11-20)30-34(32,33)24-17-13-22(14-18-24)21-6-2-1-3-7-21/h1-11,13-18,30H,28H2,(H,29,31)
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n/an/a 3.00E+3n/an/an/an/an/a37



Methylgene Inc.

US Patent


Assay Description
For deacetylase assays, 20,000 cpm of the [3H]-metabolically labeled acetylated histone substrate (M. Yoshida et al., J. Biol. Chem. 265(28): 17174-1...

US Patent US8796330 (2014)


BindingDB Entry DOI: 10.7270/Q22B8WQW
More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))		BDBM50123968
PNG
(CHEMBL166883 | N-(2-Amino-phenyl)-3-[6-(biphenyl-4...)
Show SMILES Nc1ccccc1NC(=O)\C=C\c1ccc(NS(=O)(=O)c2ccc(cc2)-c2ccccc2)nc1
Show InChI InChI=1S/C26H22N4O3S/c27-23-8-4-5-9-24(23)29-26(31)17-11-19-10-16-25(28-18-19)30-34(32,33)22-14-12-21(13-15-22)20-6-2-1-3-7-20/h1-18H,27H2,(H,28,30)(H,29,31)/b17-11+
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n/an/a 3.80E+3n/an/an/an/an/a37



Methylgene Inc.

US Patent


Assay Description
For deacetylase assays, 20,000 cpm of the [3H]-metabolically labeled acetylated histone substrate (M. Yoshida et al., J. Biol. Chem. 265(28): 17174-1...

US Patent US8796330 (2014)


BindingDB Entry DOI: 10.7270/Q22B8WQW
More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))		BDBM50123960
PNG
((E)-N-(2-Amino-phenyl)-3-[4-(3,4-dimethoxy-benzene...)
Show SMILES COc1ccc(cc1OC)S(=O)(=O)Nc1ccc(\C=C\C(=O)Nc2ccccc2N)cc1
Show InChI InChI=1S/C23H23N3O5S/c1-30-21-13-12-18(15-22(21)31-2)32(28,29)26-17-10-7-16(8-11-17)9-14-23(27)25-20-6-4-3-5-19(20)24/h3-15,26H,24H2,1-2H3,(H,25,27)/b14-9+
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n/an/a 4.00E+3n/an/an/an/an/a37



Methylgene Inc.

US Patent


Assay Description
For deacetylase assays, 20,000 cpm of the [3H]-metabolically labeled acetylated histone substrate (M. Yoshida et al., J. Biol. Chem. 265(28): 17174-1...

US Patent US8796330 (2014)


BindingDB Entry DOI: 10.7270/Q22B8WQW
More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))		BDBM128087
PNG
(US8796330, 153)
Show SMILES ONC(=O)c1ccc(CCCCCc2ccccc2)cc1
Show InChI InChI=1S/C18H21NO2/c20-18(19-21)17-13-11-16(12-14-17)10-6-2-5-9-15-7-3-1-4-8-15/h1,3-4,7-8,11-14,21H,2,5-6,9-10H2,(H,19,20)
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n/an/a 4.80E+3n/an/an/an/an/a37



Methylgene Inc.

US Patent


Assay Description
For deacetylase assays, 20,000 cpm of the [3H]-metabolically labeled acetylated histone substrate (M. Yoshida et al., J. Biol. Chem. 265(28): 17174-1...

US Patent US8796330 (2014)


BindingDB Entry DOI: 10.7270/Q22B8WQW
More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))		BDBM50123978
PNG
(CHEMBL169352 | N-(2-Amino-phenyl)-3-[4-(naphthalen...)
Show SMILES Nc1ccccc1NC(=O)\C=C\c1ccc(NS(=O)(=O)c2cccc3ccccc23)cc1
Show InChI InChI=1S/C25H21N3O3S/c26-22-9-3-4-10-23(22)27-25(29)17-14-18-12-15-20(16-13-18)28-32(30,31)24-11-5-7-19-6-1-2-8-21(19)24/h1-17,28H,26H2,(H,27,29)/b17-14+
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n/an/a 5.00E+3n/an/an/an/an/a37



Methylgene Inc.

US Patent


Assay Description
For deacetylase assays, 20,000 cpm of the [3H]-metabolically labeled acetylated histone substrate (M. Yoshida et al., J. Biol. Chem. 265(28): 17174-1...

US Patent US8796330 (2014)


BindingDB Entry DOI: 10.7270/Q22B8WQW
More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))		BDBM128091
PNG
(US8796330, 164)
Show SMILES COc1ccc(NS(=O)(=O)c2ccc(C=CC(=O)Nc3nnc(S)s3)cc2)cc1OC |w:14.13|
Show InChI InChI=1S/C19H18N4O5S3/c1-27-15-9-6-13(11-16(15)28-2)23-31(25,26)14-7-3-12(4-8-14)5-10-17(24)20-18-21-22-19(29)30-18/h3-11,23H,1-2H3,(H,22,29)(H,20,21,24)
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n/an/a 5.00E+3n/an/an/an/an/a37



Methylgene Inc.

US Patent


Assay Description
For deacetylase assays, 20,000 cpm of the [3H]-metabolically labeled acetylated histone substrate (M. Yoshida et al., J. Biol. Chem. 265(28): 17174-1...

US Patent US8796330 (2014)


BindingDB Entry DOI: 10.7270/Q22B8WQW
More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))		BDBM128080
PNG
(US8796330, 144)
Show SMILES Nc1ccccc1NC(=O)CCc1ccc(CC(=O)c2ccccc2)o1
Show InChI InChI=1S/C21H20N2O3/c22-18-8-4-5-9-19(18)23-21(25)13-12-16-10-11-17(26-16)14-20(24)15-6-2-1-3-7-15/h1-11H,12-14,22H2,(H,23,25)
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n/an/a 6.90E+3n/an/an/an/an/a37



Methylgene Inc.

US Patent


Assay Description
For deacetylase assays, 20,000 cpm of the [3H]-metabolically labeled acetylated histone substrate (M. Yoshida et al., J. Biol. Chem. 265(28): 17174-1...

US Patent US8796330 (2014)


BindingDB Entry DOI: 10.7270/Q22B8WQW
More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))		BDBM50105680
PNG
(3-(4-Benzenesulfonylamino-phenyl)-N-hydroxy-2-meth...)
Show SMILES CC(Cc1ccc(NS(=O)(=O)c2ccccc2)cc1)C(=O)NO
Show InChI InChI=1S/C16H18N2O4S/c1-12(16(19)17-20)11-13-7-9-14(10-8-13)18-23(21,22)15-5-3-2-4-6-15/h2-10,12,18,20H,11H2,1H3,(H,17,19)
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n/an/a 1.70E+4n/an/an/an/an/a37



Methylgene Inc.

US Patent


Assay Description
For deacetylase assays, 20,000 cpm of the [3H]-metabolically labeled acetylated histone substrate (M. Yoshida et al., J. Biol. Chem. 265(28): 17174-1...

US Patent US8796330 (2014)


BindingDB Entry DOI: 10.7270/Q22B8WQW
More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))		BDBM128094
PNG
(US8796330, 178)
Show SMILES Nc1ccccc1NC(=O)c1ccc(CC(=O)c2ccccc2)o1
Show InChI InChI=1S/C19H16N2O3/c20-15-8-4-5-9-16(15)21-19(23)18-11-10-14(24-18)12-17(22)13-6-2-1-3-7-13/h1-11H,12,20H2,(H,21,23)
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n/an/a>2.00E+4n/an/an/an/an/a37



Methylgene Inc.

US Patent


Assay Description
For deacetylase assays, 20,000 cpm of the [3H]-metabolically labeled acetylated histone substrate (M. Yoshida et al., J. Biol. Chem. 265(28): 17174-1...

US Patent US8796330 (2014)


BindingDB Entry DOI: 10.7270/Q22B8WQW
More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))		BDBM128076
PNG
(US8796330, 121)
Show SMILES COc1ccc(cc1OC)S(=O)(=O)Nc1ccc(CCC(=O)Nc2ccccc2N)cc1
Show InChI InChI=1S/C23H25N3O5S/c1-30-21-13-12-18(15-22(21)31-2)32(28,29)26-17-10-7-16(8-11-17)9-14-23(27)25-20-6-4-3-5-19(20)24/h3-8,10-13,15,26H,9,14,24H2,1-2H3,(H,25,27)
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US Patent
n/an/a 2.30E+4n/an/an/an/an/a37



Methylgene Inc.

US Patent


Assay Description
For deacetylase assays, 20,000 cpm of the [3H]-metabolically labeled acetylated histone substrate (M. Yoshida et al., J. Biol. Chem. 265(28): 17174-1...

US Patent US8796330 (2014)


BindingDB Entry DOI: 10.7270/Q22B8WQW
More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))		BDBM50105676
PNG
(2-(4-Benzenesulfonylamino-benzyl)-N-hydroxy-3-meth...)
Show SMILES CC(C)C(Cc1ccc(NS(=O)(=O)c2ccccc2)cc1)C(=O)NO
Show InChI InChI=1S/C18H22N2O4S/c1-13(2)17(18(21)19-22)12-14-8-10-15(11-9-14)20-25(23,24)16-6-4-3-5-7-16/h3-11,13,17,20,22H,12H2,1-2H3,(H,19,21)
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US Patent
n/an/a>2.50E+4n/an/an/an/an/a37



Methylgene Inc.

US Patent


Assay Description
For deacetylase assays, 20,000 cpm of the [3H]-metabolically labeled acetylated histone substrate (M. Yoshida et al., J. Biol. Chem. 265(28): 17174-1...

US Patent US8796330 (2014)


BindingDB Entry DOI: 10.7270/Q22B8WQW
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%