Affinity Data by USPatent=US8835659

USPatent US8835659

Found 7 hits of Enzyme Inhibition Constant Data
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
NAD-dependent protein deacetylase sirtuin-1 (Homo sapiens (Human))	BDBM131030 (US8835659, 11) Show SMILES Oc1cc(O)c2cc(oc2c1)-c1cc(O)c(O)c(O)c1 Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.84E+3	n/a	n/a	n/a	n/a	8.0	n/a
Ikerchem, S.L.; Universidad del Pais Vasco US Patent					Assay Description 50 uM of substrate peptide (acetylated AMC-labeled peptide from p53 residues 379-382, RHKKAc, BioMol. Cat. #KI-177), 91 nM of human SIRT1 (full lengt...				US Patent US8835659 (2014) BindingDB Entry DOI: 10.7270/Q29K48ZN
Ikerchem, S.L.; Universidad del Pais Vasco US Patent					More data for this Ligand-Target Pair
NAD-dependent protein deacetylase sirtuin-1 (Homo sapiens (Human))	BDBM50336799 (5,5',5''-[1,3,6-naphthalenetriyltris(sulfonylimino...) Show SMILES Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem Patents Similars	US Patent	n/a	n/a	2.62E+3	n/a	n/a	n/a	n/a	8.0	n/a
Ikerchem, S.L.; Universidad del Pais Vasco US Patent					Assay Description 50 uM of substrate peptide (acetylated AMC-labeled peptide from p53 residues 379-382, RHKKAc, BioMol. Cat. #KI-177), 91 nM of human SIRT1 (full lengt...				US Patent US8835659 (2014) BindingDB Entry DOI: 10.7270/Q29K48ZN
Ikerchem, S.L.; Universidad del Pais Vasco US Patent					More data for this Ligand-Target Pair
NAD-dependent protein deacetylase sirtuin-1 (Homo sapiens (Human))	BDBM131032 (US8835659, 15) Show SMILES Oc1ccc(cc1)-c1coc2cc(O)cc(O)c12 Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	2.28E+4	n/a	n/a	n/a	n/a	8.0	n/a
Ikerchem, S.L.; Universidad del Pais Vasco US Patent					Assay Description 50 uM of substrate peptide (acetylated AMC-labeled peptide from p53 residues 379-382, RHKKAc, BioMol. Cat. #KI-177), 91 nM of human SIRT1 (full lengt...				US Patent US8835659 (2014) BindingDB Entry DOI: 10.7270/Q29K48ZN
Ikerchem, S.L.; Universidad del Pais Vasco US Patent					More data for this Ligand-Target Pair
NAD-dependent protein deacetylase sirtuin-1 (Homo sapiens (Human))	BDBM131031 (US8835659, 13) Show SMILES Oc1cc(O)c2cc(oc2c1)-c1cc(F)cc(F)c1 Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3.67E+4	n/a	n/a	n/a	n/a	8.0	n/a
Ikerchem, S.L.; Universidad del Pais Vasco US Patent					Assay Description 50 uM of substrate peptide (acetylated AMC-labeled peptide from p53 residues 379-382, RHKKAc, BioMol. Cat. #KI-177), 91 nM of human SIRT1 (full lengt...				US Patent US8835659 (2014) BindingDB Entry DOI: 10.7270/Q29K48ZN
Ikerchem, S.L.; Universidad del Pais Vasco US Patent					More data for this Ligand-Target Pair
NAD-dependent protein deacetylase sirtuin-1 (Homo sapiens (Human))	BDBM131035 (US8835659, 20) Show SMILES Oc1cc(O)c2c(c(Br)oc2c1)-c1cc(F)cc(F)c1 Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	7.63E+4	n/a	n/a	n/a	n/a	8.0	n/a
Ikerchem, S.L.; Universidad del Pais Vasco US Patent					Assay Description 50 uM of substrate peptide (acetylated AMC-labeled peptide from p53 residues 379-382, RHKKAc, BioMol. Cat. #KI-177), 91 nM of human SIRT1 (full lengt...				US Patent US8835659 (2014) BindingDB Entry DOI: 10.7270/Q29K48ZN
Ikerchem, S.L.; Universidad del Pais Vasco US Patent					More data for this Ligand-Target Pair
NAD-dependent protein deacetylase sirtuin-1 (Homo sapiens (Human))	BDBM131034 (US8835659, 19) Show SMILES Oc1cc(O)c2c(coc2c1)-c1ccc(F)cc1 Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.92E+5	n/a	n/a	n/a	n/a	8.0	n/a
Ikerchem, S.L.; Universidad del Pais Vasco US Patent					Assay Description 50 uM of substrate peptide (acetylated AMC-labeled peptide from p53 residues 379-382, RHKKAc, BioMol. Cat. #KI-177), 91 nM of human SIRT1 (full lengt...				US Patent US8835659 (2014) BindingDB Entry DOI: 10.7270/Q29K48ZN
Ikerchem, S.L.; Universidad del Pais Vasco US Patent					More data for this Ligand-Target Pair
NAD-dependent protein deacetylase sirtuin-1 (Homo sapiens (Human))	BDBM131033 (US8835659, 16) Show SMILES Oc1cc(O)c2c(coc2c1)-c1cc(F)cc(F)c1 Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	2.74E+5	n/a	n/a	n/a	n/a	8.0	n/a
Ikerchem, S.L.; Universidad del Pais Vasco US Patent					Assay Description 50 uM of substrate peptide (acetylated AMC-labeled peptide from p53 residues 379-382, RHKKAc, BioMol. Cat. #KI-177), 91 nM of human SIRT1 (full lengt...				US Patent US8835659 (2014) BindingDB Entry DOI: 10.7270/Q29K48ZN
Ikerchem, S.L.; Universidad del Pais Vasco US Patent					More data for this Ligand-Target Pair

* indicates data uncertainty>20%