Found 98 hits of Enzyme Inhibition Constant Data Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM144689
(US8952037, 62)Show SMILES NC(=O)c1ccc(cn1)-c1cccnc1O[C@@H]1C[C@@H](C1)Nc1nc2ccccc2s1 |r,wD:16.17,18.22,(-4.65,5,;-5.98,4.23,;-7.32,5,;-5.98,2.69,;-4.65,1.93,;-4.65,.38,;-5.98,-.38,;-7.32,.38,;-7.32,1.93,;-5.98,-1.93,;-7.32,-2.69,;-7.32,-4.23,;-5.98,-5,;-4.65,-4.23,;-4.65,-2.69,;-3.32,-1.93,;-1.98,-2.69,;-.5,-2.3,;-.1,-3.78,;-1.58,-4.18,;1.24,-4.55,;2.57,-3.78,;2.73,-2.25,;4.24,-1.93,;5.01,-.6,;6.55,-.6,;7.32,-1.93,;6.55,-3.27,;5.01,-3.27,;3.98,-4.41,)| Show InChI InChI=1S/C22H19N5O2S/c23-20(28)18-8-7-13(12-25-18)16-4-3-9-24-21(16)29-15-10-14(11-15)26-22-27-17-5-1-2-6-19(17)30-22/h1-9,12,14-15H,10-11H2,(H2,23,28)(H,26,27)/t14-,15+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 0.129 | n/a | n/a | n/a | n/a | n/a | 25 |
Amgen Inc.
US Patent
| Assay Description
Enzyme Activity. An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 uL, of serial diluted P... |
US Patent US8952037 (2015)
BindingDB Entry DOI: 10.7270/Q23X85CW |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM47125
(US8952027, 63)Show SMILES NC(=O)c1ccc(cn1)-c1cccnc1O[C@@H]1C[C@@H](C1)Nc1ccc2ccccc2n1 |r,wD:16.17,18.22,(-4.94,5,;-6.28,4.23,;-7.61,5,;-6.28,2.69,;-4.94,1.93,;-4.94,.38,;-6.28,-.38,;-7.61,.38,;-7.61,1.93,;-6.28,-1.93,;-7.61,-2.69,;-7.61,-4.23,;-6.28,-5,;-4.94,-4.23,;-4.94,-2.69,;-3.61,-1.93,;-2.28,-2.69,;-.79,-2.3,;-.39,-3.78,;-1.88,-4.18,;.94,-4.55,;2.28,-3.78,;2.28,-2.24,;3.61,-1.47,;4.94,-2.24,;6.28,-1.47,;7.61,-2.24,;7.61,-3.78,;6.28,-4.55,;4.94,-3.78,;3.61,-4.55,)| Show InChI InChI=1S/C24H21N5O2/c25-23(30)21-9-7-16(14-27-21)19-5-3-11-26-24(19)31-18-12-17(13-18)28-22-10-8-15-4-1-2-6-20(15)29-22/h1-11,14,17-18H,12-13H2,(H2,25,30)(H,28,29)/t17-,18+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 0.260 | n/a | n/a | n/a | n/a | n/a | 25 |
Amgen Inc.
US Patent
| Assay Description
Enzyme Activity. An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 uL, of serial diluted P... |
US Patent US8952037 (2015)
BindingDB Entry DOI: 10.7270/Q23X85CW |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM144650
(US8952037, 17)Show SMILES O=C([C@H]1CC(C1)Oc1ncccc1C1CCOCC1)c1nc2ccccc2[nH]1 |r,wD:2.1,(1.24,-4.39,;1.24,-2.85,;-.1,-2.08,;-.5,-.6,;-1.98,-1,;-1.58,-2.48,;-3.32,-.23,;-4.65,-1,;-4.65,-2.54,;-5.98,-3.31,;-7.32,-2.54,;-7.32,-1,;-5.98,-.23,;-5.98,1.31,;-4.65,2.08,;-4.65,3.62,;-5.98,4.39,;-7.32,3.62,;-7.32,2.08,;2.57,-2.08,;2.73,-.55,;4.24,-.23,;5.01,1.1,;6.55,1.1,;7.32,-.23,;6.55,-1.57,;5.01,-1.57,;3.98,-2.71,)| | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 0.413 | n/a | n/a | n/a | n/a | n/a | 25 |
Amgen Inc.
US Patent
| Assay Description
Enzyme Activity. An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 uL, of serial diluted P... |
US Patent US8952037 (2015)
BindingDB Entry DOI: 10.7270/Q23X85CW |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM144685
(US8952037, 58 | US8952037, 59)Show SMILES N#Cc1ccc(cn1)-c1cccnc1O[C@H]1C[C@@H](C1)Nc1nc2ccccc2s1 |r,wU:17.21,wD:15.16,(-5.98,5.45,;-5.98,3.91,;-5.98,2.37,;-4.65,1.54,;-4.65,,;-5.98,-.77,;-7.32,,;-7.32,1.54,;-5.98,-2.31,;-7.32,-3.08,;-7.32,-4.62,;-5.98,-5.39,;-4.65,-4.62,;-4.65,-3.08,;-3.32,-2.31,;-1.98,-3.08,;-1.58,-4.57,;-.1,-4.17,;-.5,-2.68,;1.24,-4.94,;2.57,-4.17,;2.73,-2.64,;4.24,-2.32,;5.01,-.98,;6.55,-.98,;7.32,-2.32,;6.55,-3.65,;5.01,-3.65,;3.98,-4.8,)| Show InChI InChI=1S/C22H17N5OS/c23-12-15-8-7-14(13-25-15)18-4-3-9-24-21(18)28-17-10-16(11-17)26-22-27-19-5-1-2-6-20(19)29-22/h1-9,13,16-17H,10-11H2,(H,26,27)/t16-,17- | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 0.560 | n/a | n/a | n/a | n/a | n/a | 25 |
Amgen Inc.
US Patent
| Assay Description
Enzyme Activity. An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 uL, of serial diluted P... |
US Patent US8952037 (2015)
BindingDB Entry DOI: 10.7270/Q23X85CW |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM144718
(US8952037, 95)Show SMILES N#C[C@@H]1CCN(C1)c1nccnc1O[C@@H]1C[C@@H](C1)Nc1nc2ccccc2s1 |r,wU:2.1,wD:14.15,16.20,(-3.42,10.22,;-4.31,8.96,;-5.19,7.7,;-6.75,7.61,;-7.23,6.15,;-5.98,5.24,;-4.74,6.15,;-5.98,3.7,;-7.32,2.93,;-7.32,1.39,;-5.98,.62,;-4.65,1.39,;-4.65,2.93,;-3.32,3.7,;-1.98,2.93,;-.5,3.33,;-.1,1.84,;-1.58,1.44,;1.24,1.07,;2.57,1.84,;2.73,3.37,;4.24,3.69,;5.01,5.03,;6.55,5.03,;7.32,3.69,;6.55,2.36,;5.01,2.36,;3.98,1.22,)| Show InChI InChI=1S/C20H20N6OS/c21-11-13-5-8-26(12-13)18-19(23-7-6-22-18)27-15-9-14(10-15)24-20-25-16-3-1-2-4-17(16)28-20/h1-4,6-7,13-15H,5,8-10,12H2,(H,24,25)/t13-,14-,15+/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 0.728 | n/a | n/a | n/a | n/a | n/a | 25 |
Amgen Inc.
US Patent
| Assay Description
Enzyme Activity. An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 uL, of serial diluted P... |
US Patent US8952037 (2015)
BindingDB Entry DOI: 10.7270/Q23X85CW |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM144659
(US8952037, 26)Show SMILES C1[C@@H](C[C@@H]1Oc1ncccc1C1CCOCC1)Nc1nc2ccccc2s1 |r,wU:3.4,1.19,(-1.73,-3.03,;-.24,-2.63,;-.64,-1.14,;-2.12,-1.54,;-3.46,-.77,;-4.79,-1.54,;-4.79,-3.08,;-6.12,-3.85,;-7.46,-3.08,;-7.46,-1.54,;-6.12,-.77,;-6.12,.77,;-4.79,1.54,;-4.79,3.08,;-6.12,3.85,;-7.46,3.08,;-7.46,1.54,;1.1,-3.4,;2.43,-2.63,;2.91,-1.16,;4.45,-1.16,;5.48,-.02,;6.98,-.34,;7.46,-1.8,;6.43,-2.95,;4.92,-2.63,;3.68,-3.53,)| Show InChI InChI=1S/C21H23N3O2S/c1-2-6-19-18(5-1)24-21(27-19)23-15-12-16(13-15)26-20-17(4-3-9-22-20)14-7-10-25-11-8-14/h1-6,9,14-16H,7-8,10-13H2,(H,23,24)/t15-,16+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 0.751 | n/a | n/a | n/a | n/a | n/a | 25 |
Amgen Inc.
US Patent
| Assay Description
Enzyme Activity. An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 uL, of serial diluted P... |
US Patent US8952037 (2015)
BindingDB Entry DOI: 10.7270/Q23X85CW |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM144699
(US8952037, 72)Show SMILES COCC(=O)N1CCC(CC1)c1cccnc1O[C@@H]1C[C@@H](C1)Nc1ccc2ccccc2n1 |r,wD:18.19,20.24,(-2.28,5.01,;-3.61,4.24,;-4.94,5,;-6.28,4.23,;-7.61,5,;-6.28,2.69,;-7.61,1.92,;-7.61,.38,;-6.28,-.39,;-4.94,.38,;-4.94,1.92,;-6.28,-1.93,;-7.61,-2.7,;-7.61,-4.24,;-6.28,-5.01,;-4.94,-4.24,;-4.94,-2.7,;-3.61,-1.93,;-2.28,-2.7,;-.79,-2.3,;-.39,-3.78,;-1.88,-4.18,;.94,-4.55,;2.28,-3.78,;2.28,-2.24,;3.61,-1.47,;4.94,-2.24,;6.28,-1.47,;7.61,-2.24,;7.61,-3.78,;6.28,-4.55,;4.94,-3.78,;3.61,-4.55,)| Show InChI InChI=1S/C26H30N4O3/c1-32-17-25(31)30-13-10-18(11-14-30)22-6-4-12-27-26(22)33-21-15-20(16-21)28-24-9-8-19-5-2-3-7-23(19)29-24/h2-9,12,18,20-21H,10-11,13-17H2,1H3,(H,28,29)/t20-,21+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 0.948 | n/a | n/a | n/a | n/a | n/a | 25 |
Amgen Inc.
US Patent
| Assay Description
Enzyme Activity. An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 uL, of serial diluted P... |
US Patent US8952037 (2015)
BindingDB Entry DOI: 10.7270/Q23X85CW |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM144703
(US8952037, 78)Show SMILES N#CC1CCN(C1)c1nccnc1O[C@@H]1C[C@@H](C1)Nc1nc2ccccc2s1 |r,wD:14.15,16.20,(-3.42,4.77,;-4.31,3.51,;-5.19,2.25,;-6.75,2.16,;-7.23,.7,;-5.98,-.21,;-4.74,.7,;-5.98,-1.75,;-7.32,-2.52,;-7.32,-4.06,;-5.98,-4.83,;-4.65,-4.06,;-4.65,-2.52,;-3.32,-1.75,;-1.98,-2.52,;-.5,-2.12,;-.1,-3.61,;-1.58,-4.01,;1.24,-4.38,;2.57,-3.61,;2.73,-2.08,;4.24,-1.76,;5.01,-.42,;6.55,-.42,;7.32,-1.76,;6.55,-3.09,;5.01,-3.09,;3.98,-4.23,)| Show InChI InChI=1S/C20H20N6OS/c21-11-13-5-8-26(12-13)18-19(23-7-6-22-18)27-15-9-14(10-15)24-20-25-16-3-1-2-4-17(16)28-20/h1-4,6-7,13-15H,5,8-10,12H2,(H,24,25)/t13?,14-,15+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 1.07 | n/a | n/a | n/a | n/a | n/a | 25 |
Amgen Inc.
US Patent
| Assay Description
Enzyme Activity. An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 uL, of serial diluted P... |
US Patent US8952037 (2015)
BindingDB Entry DOI: 10.7270/Q23X85CW |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM144721
(US8952037, 104)Show SMILES N#CC1CCN(CC1)c1cccnc1O[C@@H]1C[C@@H](C1)Nc1nc2ccccc2s1 |r,wD:15.16,17.21,(-5.71,5.83,;-5.71,4.29,;-5.71,2.75,;-4.37,1.93,;-4.37,.39,;-5.71,-.38,;-7.04,.39,;-7.04,1.93,;-5.71,-1.92,;-7.04,-2.69,;-7.04,-4.23,;-5.71,-5,;-4.37,-4.23,;-4.37,-2.69,;-3.04,-1.92,;-1.95,-3.01,;-.41,-3.01,;-.41,-4.55,;-1.95,-4.55,;.68,-5.64,;2.01,-4.87,;2.49,-3.41,;4.03,-3.41,;5.06,-2.26,;6.56,-2.58,;7.04,-4.05,;6.01,-5.19,;4.5,-4.87,;3.26,-5.78,)| Show InChI InChI=1S/C22H23N5OS/c23-14-15-7-10-27(11-8-15)19-5-3-9-24-21(19)28-17-12-16(13-17)25-22-26-18-4-1-2-6-20(18)29-22/h1-6,9,15-17H,7-8,10-13H2,(H,25,26)/t16-,17+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 1.25 | n/a | n/a | n/a | n/a | n/a | 25 |
Amgen Inc.
US Patent
| Assay Description
Enzyme Activity. An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 uL, of serial diluted P... |
US Patent US8952037 (2015)
BindingDB Entry DOI: 10.7270/Q23X85CW |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM144682
(US8952037, 55)Show SMILES N#Cc1ccc(cn1)-c1cccnc1O[C@@H]1C[C@@H](C1)Nc1ccc2ccccc2n1 |r,wD:15.16,17.21,(-6.28,5.39,;-6.28,3.85,;-6.28,2.31,;-4.94,1.54,;-4.94,,;-6.28,-.77,;-7.61,,;-7.61,1.54,;-6.28,-2.31,;-7.61,-3.08,;-7.61,-4.62,;-6.28,-5.39,;-4.94,-4.62,;-4.94,-3.08,;-3.61,-2.31,;-2.28,-3.08,;-.79,-2.68,;-.39,-4.17,;-1.88,-4.57,;.94,-4.94,;2.28,-4.17,;2.28,-2.63,;3.61,-1.86,;4.94,-2.63,;6.28,-1.86,;7.61,-2.63,;7.61,-4.17,;6.28,-4.94,;4.94,-4.17,;3.61,-4.94,)| Show InChI InChI=1S/C24H19N5O/c25-14-18-9-7-17(15-27-18)21-5-3-11-26-24(21)30-20-12-19(13-20)28-23-10-8-16-4-1-2-6-22(16)29-23/h1-11,15,19-20H,12-13H2,(H,28,29)/t19-,20+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 1.29 | n/a | n/a | n/a | n/a | n/a | 25 |
Amgen Inc.
US Patent
| Assay Description
Enzyme Activity. An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 uL, of serial diluted P... |
US Patent US8952037 (2015)
BindingDB Entry DOI: 10.7270/Q23X85CW |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM144696
(US8952037, 69)Show SMILES COCC(=O)N1CCC(CC1)c1cccnc1O[C@@H]1C[C@@H](C1)Nc1nc2ccccc2s1 |r,wD:18.19,20.24,(-1.56,5.77,;-2.89,5,;-4.22,5.77,;-5.56,5,;-6.65,6.09,;-5.56,3.46,;-6.89,2.69,;-6.89,1.15,;-5.56,.38,;-4.22,1.15,;-4.22,2.69,;-5.56,-1.16,;-6.89,-1.93,;-6.89,-3.47,;-5.56,-4.24,;-4.22,-3.47,;-4.22,-1.93,;-2.89,-1.16,;-1.8,-2.24,;-.26,-2.24,;-.26,-3.78,;-1.8,-3.78,;.83,-4.87,;2.16,-4.1,;2.32,-2.57,;3.83,-2.25,;4.6,-.92,;6.14,-.92,;6.91,-2.25,;6.14,-3.58,;4.6,-3.58,;3.57,-4.73,)| Show InChI InChI=1S/C24H28N4O3S/c1-30-15-22(29)28-11-8-16(9-12-28)19-5-4-10-25-23(19)31-18-13-17(14-18)26-24-27-20-6-2-3-7-21(20)32-24/h2-7,10,16-18H,8-9,11-15H2,1H3,(H,26,27)/t17-,18+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 1.29 | n/a | n/a | n/a | n/a | n/a | 25 |
Amgen Inc.
US Patent
| Assay Description
Enzyme Activity. An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 uL, of serial diluted P... |
US Patent US8952037 (2015)
BindingDB Entry DOI: 10.7270/Q23X85CW |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM144698
(US8952037, 71)Show SMILES CC(=O)N1CCC(CC1)c1cccnc1O[C@@H]1C[C@@H](C1)Nc1ccc2ccccc2n1 |r,wD:16.17,18.22,(-4.94,5,;-6.28,4.23,;-7.61,5,;-6.28,2.69,;-7.61,1.92,;-7.61,.38,;-6.28,-.39,;-4.94,.38,;-4.94,1.92,;-6.28,-1.93,;-7.61,-2.7,;-7.61,-4.24,;-6.28,-5.01,;-4.94,-4.24,;-4.94,-2.7,;-3.61,-1.93,;-2.28,-2.7,;-.79,-2.3,;-.39,-3.78,;-1.88,-4.18,;.94,-4.55,;2.28,-3.78,;2.28,-2.24,;3.61,-1.47,;4.94,-2.24,;6.28,-1.47,;7.61,-2.24,;7.61,-3.78,;6.28,-4.55,;4.94,-3.78,;3.61,-4.55,)| Show InChI InChI=1S/C25H28N4O2/c1-17(30)29-13-10-18(11-14-29)22-6-4-12-26-25(22)31-21-15-20(16-21)27-24-9-8-19-5-2-3-7-23(19)28-24/h2-9,12,18,20-21H,10-11,13-16H2,1H3,(H,27,28)/t20-,21+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 1.32 | n/a | n/a | n/a | n/a | n/a | 25 |
Amgen Inc.
US Patent
| Assay Description
Enzyme Activity. An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 uL, of serial diluted P... |
US Patent US8952037 (2015)
BindingDB Entry DOI: 10.7270/Q23X85CW |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM144666
(US8952037, 39)Show SMILES Fc1ccc2nc(N[C@H]3C[C@H](C3)Oc3ncc(F)cc3C3CCOCC3)sc2c1 |r,wU:10.12,8.7,(8.75,-.78,;7.21,-.78,;6.44,.56,;4.9,.56,;4.13,-.78,;2.63,-1.1,;2.47,-2.63,;1.13,-3.4,;-.2,-2.63,;-1.69,-3.03,;-2.09,-1.54,;-.6,-1.14,;-3.42,-.77,;-4.75,-1.54,;-4.75,-3.08,;-6.09,-3.85,;-7.42,-3.08,;-8.75,-3.85,;-7.42,-1.54,;-6.09,-.77,;-6.09,.77,;-7.42,1.54,;-7.42,3.08,;-6.09,3.85,;-4.75,3.08,;-4.75,1.54,;3.87,-3.26,;4.9,-2.11,;6.44,-2.11,)| Show InChI InChI=1S/C21H21F2N3O2S/c22-13-1-2-18-19(8-13)29-21(26-18)25-15-9-16(10-15)28-20-17(7-14(23)11-24-20)12-3-5-27-6-4-12/h1-2,7-8,11-12,15-16H,3-6,9-10H2,(H,25,26)/t15-,16+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 1.44 | n/a | n/a | n/a | n/a | n/a | 25 |
Amgen Inc.
US Patent
| Assay Description
Enzyme Activity. An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 uL, of serial diluted P... |
US Patent US8952037 (2015)
BindingDB Entry DOI: 10.7270/Q23X85CW |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM144729
(US8952037, 112)Show SMILES C1[C@@H](C[C@@H]1Oc1ncccc1C1CCOCC1)Nc1ccc2ccccc2n1 |r,wD:3.4,1.19,(-.79,-1.14,;-.39,-2.63,;-1.88,-3.03,;-2.28,-1.54,;-3.61,-.77,;-4.94,-1.54,;-4.94,-3.08,;-6.28,-3.85,;-7.61,-3.08,;-7.61,-1.54,;-6.28,-.77,;-6.28,.77,;-4.94,1.54,;-4.94,3.08,;-6.28,3.85,;-7.61,3.08,;-7.61,1.54,;.94,-3.4,;2.28,-2.63,;2.28,-1.09,;3.61,-.32,;4.94,-1.09,;6.28,-.32,;7.61,-1.09,;7.61,-2.63,;6.28,-3.4,;4.94,-2.63,;3.61,-3.4,)| Show InChI InChI=1S/C23H25N3O2/c1-2-6-21-17(4-1)7-8-22(26-21)25-18-14-19(15-18)28-23-20(5-3-11-24-23)16-9-12-27-13-10-16/h1-8,11,16,18-19H,9-10,12-15H2,(H,25,26)/t18-,19+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 1.5 | n/a | n/a | n/a | n/a | n/a | 25 |
Amgen Inc.
US Patent
| Assay Description
Enzyme Activity. An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 uL, of serial diluted P... |
US Patent US8952037 (2015)
BindingDB Entry DOI: 10.7270/Q23X85CW |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM144654
(US8952037, 21)Show SMILES C1[C@@H](C[C@@H]1Oc1ncccc1C1CCOCC1)Nc1nc2ccccc2[nH]1 |r,wU:3.4,1.19,(-1.8,-3.09,;-.26,-3.09,;-.26,-1.55,;-1.8,-1.55,;-2.89,-.46,;-4.37,-.86,;-4.77,-2.35,;-6.26,-2.75,;-7.35,-1.66,;-6.95,-.17,;-5.46,.23,;-5.06,1.71,;-3.58,2.11,;-3.18,3.6,;-4.27,4.69,;-5.75,4.29,;-6.15,2.8,;.83,-4.18,;2.32,-3.78,;2.8,-2.32,;4.34,-2.32,;5.37,-1.17,;6.87,-1.49,;7.35,-2.96,;6.32,-4.1,;4.81,-3.78,;3.57,-4.69,)| | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 1.53 | n/a | n/a | n/a | n/a | n/a | 25 |
Amgen Inc.
US Patent
| Assay Description
Enzyme Activity. An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 uL, of serial diluted P... |
US Patent US8952037 (2015)
BindingDB Entry DOI: 10.7270/Q23X85CW |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM144676
(US8952037, 49)Show SMILES Cc1ncccc1-c1nccnc1O[C@@H]1C[C@@H](C1)Nc1nc2ccccc2s1 |r,wU:14.15,16.20,(-3.32,.77,;-4.65,1.54,;-4.65,3.08,;-5.98,3.85,;-7.32,3.08,;-7.32,1.54,;-5.98,.77,;-5.98,-.77,;-7.32,-1.54,;-7.32,-3.08,;-5.98,-3.85,;-4.65,-3.08,;-4.65,-1.54,;-3.32,-.77,;-1.98,-1.54,;-1.58,-3.03,;-.1,-2.63,;-.5,-1.14,;1.24,-3.4,;2.57,-2.63,;2.73,-1.1,;4.24,-.78,;5.01,.56,;6.55,.56,;7.32,-.78,;6.55,-2.11,;5.01,-2.11,;3.98,-3.26,)| Show InChI InChI=1S/C21H19N5OS/c1-13-16(5-4-8-22-13)19-20(24-10-9-23-19)27-15-11-14(12-15)25-21-26-17-6-2-3-7-18(17)28-21/h2-10,14-15H,11-12H2,1H3,(H,25,26)/t14-,15+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 1.94 | n/a | n/a | n/a | n/a | n/a | 25 |
Amgen Inc.
US Patent
| Assay Description
Enzyme Activity. An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 uL, of serial diluted P... |
US Patent US8952037 (2015)
BindingDB Entry DOI: 10.7270/Q23X85CW |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM144713
(US8952037, 88)Show SMILES N#CC1CCN(CC1)c1nccnc1O[C@@H]1C[C@@H](C1)Nc1ccc2ccccc2n1 |r,wD:15.16,17.21,(-6.28,5.39,;-6.28,3.85,;-6.28,2.31,;-4.94,1.54,;-4.94,,;-6.28,-.77,;-7.61,,;-7.61,1.54,;-6.28,-2.31,;-7.61,-3.08,;-7.61,-4.62,;-6.28,-5.39,;-4.94,-4.62,;-4.94,-3.08,;-3.61,-2.31,;-2.28,-3.08,;-.79,-2.68,;-.39,-4.17,;-1.88,-4.57,;.94,-4.94,;2.28,-4.17,;2.28,-2.63,;3.61,-1.86,;4.94,-2.63,;6.28,-1.86,;7.61,-2.63,;7.61,-4.17,;6.28,-4.94,;4.94,-4.17,;3.61,-4.94,)| Show InChI InChI=1S/C23H24N6O/c24-15-16-7-11-29(12-8-16)22-23(26-10-9-25-22)30-19-13-18(14-19)27-21-6-5-17-3-1-2-4-20(17)28-21/h1-6,9-10,16,18-19H,7-8,11-14H2,(H,27,28)/t18-,19+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 2.26 | n/a | n/a | n/a | n/a | n/a | 25 |
Amgen Inc.
US Patent
| Assay Description
Enzyme Activity. An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 uL, of serial diluted P... |
US Patent US8952037 (2015)
BindingDB Entry DOI: 10.7270/Q23X85CW |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM144711
(US8952037, 86)Show SMILES N#CC1CCN(CC1)c1nccnc1O[C@@H]1C[C@@H](C1)Nc1nc2ccccc2s1 |r,wD:15.16,17.21,(-5.98,5.39,;-5.98,3.85,;-5.98,2.31,;-4.65,1.54,;-4.65,,;-5.98,-.77,;-7.32,,;-7.32,1.54,;-5.98,-2.31,;-7.32,-3.08,;-7.32,-4.62,;-5.98,-5.39,;-4.65,-4.62,;-4.65,-3.08,;-3.32,-2.31,;-1.98,-3.08,;-.5,-2.68,;-.1,-4.17,;-1.58,-4.57,;1.24,-4.94,;2.57,-4.17,;2.73,-2.64,;4.24,-2.32,;5.01,-.98,;6.55,-.98,;7.32,-2.32,;6.55,-3.65,;5.01,-3.65,;3.98,-4.8,)| Show InChI InChI=1S/C21H22N6OS/c22-13-14-5-9-27(10-6-14)19-20(24-8-7-23-19)28-16-11-15(12-16)25-21-26-17-3-1-2-4-18(17)29-21/h1-4,7-8,14-16H,5-6,9-12H2,(H,25,26)/t15-,16+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 2.31 | n/a | n/a | n/a | n/a | n/a | 25 |
Amgen Inc.
US Patent
| Assay Description
Enzyme Activity. An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 uL, of serial diluted P... |
US Patent US8952037 (2015)
BindingDB Entry DOI: 10.7270/Q23X85CW |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM144680
(US8952037, 53)Show SMILES Cc1ccc(cn1)-c1nccnc1O[C@@H]1C[C@@H](C1)Nc1ncc2ccccc2n1 |r,wD:14.15,16.20,(-6.28,4.62,;-6.28,3.08,;-4.94,2.31,;-4.94,.77,;-6.28,,;-7.61,.77,;-7.61,2.31,;-6.28,-1.54,;-7.61,-2.31,;-7.61,-3.85,;-6.28,-4.62,;-4.94,-3.85,;-4.94,-2.31,;-3.61,-1.54,;-2.28,-2.31,;-.79,-1.91,;-.39,-3.4,;-1.88,-3.8,;.94,-4.17,;2.28,-3.4,;2.28,-1.86,;3.61,-1.09,;4.94,-1.86,;6.28,-1.09,;7.61,-1.86,;7.61,-3.4,;6.28,-4.17,;4.94,-3.4,;3.61,-4.17,)| Show InChI InChI=1S/C22H20N6O/c1-14-6-7-16(13-25-14)20-21(24-9-8-23-20)29-18-10-17(11-18)27-22-26-12-15-4-2-3-5-19(15)28-22/h2-9,12-13,17-18H,10-11H2,1H3,(H,26,27,28)/t17-,18+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 2.43 | n/a | n/a | n/a | n/a | n/a | 25 |
Amgen Inc.
US Patent
| Assay Description
Enzyme Activity. An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 uL, of serial diluted P... |
US Patent US8952037 (2015)
BindingDB Entry DOI: 10.7270/Q23X85CW |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM144667
(US8952037, 40)Show SMILES Fc1cnc(O[C@@H]2C[C@@H](C2)Nc2nc3cccc(F)c3s2)c(c1)C1CCOCC1 |r,wU:6.5,8.10,(-7.98,-3.85,;-6.65,-3.08,;-5.32,-3.85,;-3.98,-3.08,;-3.98,-1.54,;-2.65,-.77,;-1.32,-1.54,;-.92,-3.03,;.57,-2.63,;.17,-1.14,;1.9,-3.4,;3.24,-2.63,;3.4,-1.1,;4.9,-.78,;5.67,.56,;7.21,.56,;7.98,-.78,;7.21,-2.11,;7.98,-3.44,;5.67,-2.11,;4.64,-3.26,;-5.32,-.77,;-6.65,-1.54,;-5.32,.77,;-6.65,1.54,;-6.65,3.08,;-5.32,3.85,;-3.98,3.08,;-3.98,1.54,)| Show InChI InChI=1S/C21H21F2N3O2S/c22-13-8-16(12-4-6-27-7-5-12)20(24-11-13)28-15-9-14(10-15)25-21-26-18-3-1-2-17(23)19(18)29-21/h1-3,8,11-12,14-15H,4-7,9-10H2,(H,25,26)/t14-,15+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 2.45 | n/a | n/a | n/a | n/a | n/a | 25 |
Amgen Inc.
US Patent
| Assay Description
Enzyme Activity. An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 uL, of serial diluted P... |
US Patent US8952037 (2015)
BindingDB Entry DOI: 10.7270/Q23X85CW |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM144655
(US8952037, 22)Show SMILES C1[C@@H](C[C@H]1Oc1ncccc1C1CCOCC1)Nc1nc2ccccc2[nH]1 |r,wU:3.4,wD:1.19,(-.26,-1.55,;-.26,-3.09,;-1.8,-3.09,;-1.8,-1.55,;-2.89,-.46,;-4.37,-.86,;-4.77,-2.35,;-6.26,-2.75,;-7.35,-1.66,;-6.95,-.17,;-5.46,.23,;-5.06,1.71,;-3.58,2.11,;-3.18,3.6,;-4.27,4.69,;-5.75,4.29,;-6.15,2.8,;.83,-4.18,;2.32,-3.78,;2.8,-2.32,;4.34,-2.32,;5.37,-1.17,;6.87,-1.49,;7.35,-2.96,;6.32,-4.1,;4.81,-3.78,;3.57,-4.69,)| | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 2.63 | n/a | n/a | n/a | n/a | n/a | 25 |
Amgen Inc.
US Patent
| Assay Description
Enzyme Activity. An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 uL, of serial diluted P... |
US Patent US8952037 (2015)
BindingDB Entry DOI: 10.7270/Q23X85CW |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM144677
(US8952037, 50)Show SMILES CC(=O)c1ccc(cn1)-c1nccnc1O[C@@H]1C[C@@H](C1)Nc1nc2ccccc2s1 |r,wU:18.22,16.17,(-.02,-5.71,;1.52,-5.71,;2.29,-7.05,;2.29,-4.38,;1.52,-3.05,;2.29,-1.71,;3.83,-1.71,;4.6,-3.05,;3.83,-4.38,;4.6,-.38,;6.14,-.38,;6.91,.95,;6.14,2.29,;4.6,2.29,;3.83,.95,;2.29,.95,;1.52,2.29,;1.92,3.78,;.43,4.17,;.04,2.69,;-.34,5.51,;-1.88,5.51,;-2.78,4.26,;-4.25,4.74,;-5.58,3.97,;-6.91,4.74,;-6.91,6.28,;-5.58,7.05,;-4.25,6.28,;-2.78,6.75,)| Show InChI InChI=1S/C22H19N5O2S/c1-13(28)17-7-6-14(12-25-17)20-21(24-9-8-23-20)29-16-10-15(11-16)26-22-27-18-4-2-3-5-19(18)30-22/h2-9,12,15-16H,10-11H2,1H3,(H,26,27)/t15-,16+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 2.74 | n/a | n/a | n/a | n/a | n/a | 25 |
Amgen Inc.
US Patent
| Assay Description
Enzyme Activity. An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 uL, of serial diluted P... |
US Patent US8952037 (2015)
BindingDB Entry DOI: 10.7270/Q23X85CW |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM144647
(US8952037, 14)Show SMILES CC(=O)N1CCC(CC1)c1nccnc1O[C@@H]1C[C@@H](C1)Nc1nc2ccccc2s1 |r,wU:16.17,18.22,(-4.65,5,;-5.98,4.23,;-7.32,5,;-5.98,2.69,;-4.65,1.93,;-4.65,.38,;-5.98,-.38,;-7.32,.38,;-7.32,1.93,;-5.98,-1.93,;-7.32,-2.69,;-7.32,-4.23,;-5.98,-5,;-4.65,-4.23,;-4.65,-2.69,;-3.32,-1.93,;-1.98,-2.69,;-1.58,-4.18,;-.1,-3.78,;-.5,-2.3,;1.24,-4.55,;2.57,-3.78,;2.73,-2.25,;4.24,-1.93,;5.01,-.6,;6.55,-.6,;7.32,-1.93,;6.55,-3.27,;5.01,-3.27,;3.98,-4.41,)| Show InChI InChI=1S/C22H25N5O2S/c1-14(28)27-10-6-15(7-11-27)20-21(24-9-8-23-20)29-17-12-16(13-17)25-22-26-18-4-2-3-5-19(18)30-22/h2-5,8-9,15-17H,6-7,10-13H2,1H3,(H,25,26)/t16-,17+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 2.77 | n/a | n/a | n/a | n/a | n/a | 25 |
Amgen Inc.
US Patent
| Assay Description
Enzyme Activity. An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 uL, of serial diluted P... |
US Patent US8952037 (2015)
BindingDB Entry DOI: 10.7270/Q23X85CW |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM144731
(US8952037, 92)Show SMILES OC[C@@H]1CCCN(C1)c1nccnc1O[C@@H]1C[C@@H](C1)Nc1nc2ccccc2s1 |r,wU:2.1,wD:15.16,17.21,(-1.98,8.15,;-3.32,8.92,;-4.65,8.15,;-5.98,8.92,;-7.32,8.15,;-7.32,6.61,;-5.98,5.84,;-4.65,6.61,;-5.98,4.3,;-7.32,3.53,;-7.32,1.99,;-5.98,1.22,;-4.65,1.99,;-4.65,3.53,;-3.32,4.3,;-1.98,3.53,;-.5,3.92,;-.1,2.44,;-1.58,2.04,;1.24,1.67,;2.57,2.44,;2.73,3.97,;4.24,4.29,;5.01,5.62,;6.55,5.62,;7.32,4.29,;6.55,2.96,;5.01,2.96,;3.98,1.81,)| Show InChI InChI=1S/C21H25N5O2S/c27-13-14-4-3-9-26(12-14)19-20(23-8-7-22-19)28-16-10-15(11-16)24-21-25-17-5-1-2-6-18(17)29-21/h1-2,5-8,14-16,27H,3-4,9-13H2,(H,24,25)/t14-,15-,16+/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 2.81 | n/a | n/a | n/a | n/a | n/a | 25 |
Amgen Inc.
US Patent
| Assay Description
Enzyme Activity. An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 uL, of serial diluted P... |
US Patent US8952037 (2015)
BindingDB Entry DOI: 10.7270/Q23X85CW |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM144687
(US8952037, 60)Show SMILES NC(=O)c1ccc(cn1)-c1nccnc1O[C@@H]1C[C@@H](C1)Nc1nc2ccccc2s1 |r,wD:16.17,18.22,(-4.65,5,;-5.98,4.23,;-7.32,5,;-5.98,2.69,;-4.65,1.93,;-4.65,.38,;-5.98,-.38,;-7.32,.38,;-7.32,1.93,;-5.98,-1.93,;-7.32,-2.69,;-7.32,-4.23,;-5.98,-5,;-4.65,-4.23,;-4.65,-2.69,;-3.32,-1.93,;-1.98,-2.69,;-.5,-2.3,;-.1,-3.78,;-1.58,-4.18,;1.24,-4.55,;2.57,-3.78,;2.73,-2.25,;4.24,-1.93,;5.01,-.6,;6.55,-.6,;7.32,-1.93,;6.55,-3.27,;5.01,-3.27,;3.98,-4.41,)| Show InChI InChI=1S/C21H18N6O2S/c22-19(28)16-6-5-12(11-25-16)18-20(24-8-7-23-18)29-14-9-13(10-14)26-21-27-15-3-1-2-4-17(15)30-21/h1-8,11,13-14H,9-10H2,(H2,22,28)(H,26,27)/t13-,14+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 2.96 | n/a | n/a | n/a | n/a | n/a | 25 |
Amgen Inc.
US Patent
| Assay Description
Enzyme Activity. An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 uL, of serial diluted P... |
US Patent US8952037 (2015)
BindingDB Entry DOI: 10.7270/Q23X85CW |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM144685
(US8952037, 58 | US8952037, 59)Show SMILES N#Cc1ccc(cn1)-c1cccnc1O[C@H]1C[C@@H](C1)Nc1nc2ccccc2s1 |r,wU:17.21,wD:15.16,(-5.98,5.45,;-5.98,3.91,;-5.98,2.37,;-4.65,1.54,;-4.65,,;-5.98,-.77,;-7.32,,;-7.32,1.54,;-5.98,-2.31,;-7.32,-3.08,;-7.32,-4.62,;-5.98,-5.39,;-4.65,-4.62,;-4.65,-3.08,;-3.32,-2.31,;-1.98,-3.08,;-1.58,-4.57,;-.1,-4.17,;-.5,-2.68,;1.24,-4.94,;2.57,-4.17,;2.73,-2.64,;4.24,-2.32,;5.01,-.98,;6.55,-.98,;7.32,-2.32,;6.55,-3.65,;5.01,-3.65,;3.98,-4.8,)| Show InChI InChI=1S/C22H17N5OS/c23-12-15-8-7-14(13-25-15)18-4-3-9-24-21(18)28-17-10-16(11-17)26-22-27-19-5-1-2-6-20(19)29-22/h1-9,13,16-17H,10-11H2,(H,26,27)/t16-,17- | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 2.97 | n/a | n/a | n/a | n/a | n/a | 25 |
Amgen Inc.
US Patent
| Assay Description
Enzyme Activity. An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 uL, of serial diluted P... |
US Patent US8952037 (2015)
BindingDB Entry DOI: 10.7270/Q23X85CW |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM144700
(US8952037, 75)Show SMILES OCC1CCN(CC1)c1nccnc1O[C@@H]1C[C@@H](C1)Nc1nc2ccccc2s1 |r,wD:15.16,17.21,(-7.32,5.01,;-5.98,4.23,;-5.98,2.69,;-7.32,1.92,;-7.32,.38,;-5.98,-.39,;-4.65,.38,;-4.65,1.92,;-5.98,-1.93,;-7.32,-2.7,;-7.32,-4.24,;-5.98,-5.01,;-4.65,-4.24,;-4.65,-2.7,;-3.32,-1.93,;-1.98,-2.7,;-.5,-2.3,;-.1,-3.78,;-1.58,-4.18,;1.24,-4.55,;2.57,-3.78,;2.73,-2.25,;4.24,-1.93,;5.01,-.6,;6.55,-.6,;7.32,-1.93,;6.55,-3.27,;5.01,-3.27,;3.98,-4.41,)| Show InChI InChI=1S/C21H25N5O2S/c27-13-14-5-9-26(10-6-14)19-20(23-8-7-22-19)28-16-11-15(12-16)24-21-25-17-3-1-2-4-18(17)29-21/h1-4,7-8,14-16,27H,5-6,9-13H2,(H,24,25)/t15-,16+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 3.16 | n/a | n/a | n/a | n/a | n/a | 25 |
Amgen Inc.
US Patent
| Assay Description
Enzyme Activity. An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 uL, of serial diluted P... |
US Patent US8952037 (2015)
BindingDB Entry DOI: 10.7270/Q23X85CW |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM144697
(US8952037, 70)Show SMILES COC(=O)N1CCC(CC1)c1cccnc1O[C@@H]1C[C@@H](C1)Nc1nc2ccccc2s1 |r,wD:17.18,19.23,(-3.32,3.91,;-4.65,4.68,;-5.98,3.91,;-7.07,4.99,;-5.98,2.37,;-7.32,1.54,;-7.32,,;-5.98,-.77,;-4.65,,;-4.65,1.54,;-5.98,-2.31,;-7.32,-3.08,;-7.32,-4.62,;-5.98,-5.39,;-4.65,-4.62,;-4.65,-3.08,;-3.32,-2.31,;-1.98,-3.08,;-.5,-2.68,;-.1,-4.17,;-1.58,-4.57,;1.24,-4.94,;2.57,-4.17,;2.73,-2.64,;4.24,-2.32,;5.01,-.98,;6.55,-.98,;7.32,-2.32,;6.55,-3.65,;5.01,-3.65,;3.98,-4.8,)| Show InChI InChI=1S/C23H26N4O3S/c1-29-23(28)27-11-8-15(9-12-27)18-5-4-10-24-21(18)30-17-13-16(14-17)25-22-26-19-6-2-3-7-20(19)31-22/h2-7,10,15-17H,8-9,11-14H2,1H3,(H,25,26)/t16-,17+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 3.18 | n/a | n/a | n/a | n/a | n/a | 25 |
Amgen Inc.
US Patent
| Assay Description
Enzyme Activity. An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 uL, of serial diluted P... |
US Patent US8952037 (2015)
BindingDB Entry DOI: 10.7270/Q23X85CW |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM144658
(US8952037, 25)Show SMILES C1[C@@H](C[C@H]1Oc1ncccc1C1CCOCC1)Nc1nc2ccccc2s1 |r,wU:3.4,wD:1.19,(-.64,-1.14,;-.24,-2.63,;-1.73,-3.03,;-2.12,-1.54,;-3.46,-.77,;-4.79,-1.54,;-4.79,-3.08,;-6.12,-3.85,;-7.46,-3.08,;-7.46,-1.54,;-6.12,-.77,;-6.12,.77,;-4.79,1.54,;-4.79,3.08,;-6.12,3.85,;-7.46,3.08,;-7.46,1.54,;1.1,-3.4,;2.43,-2.63,;2.91,-1.16,;4.45,-1.16,;5.48,-.02,;6.98,-.34,;7.46,-1.8,;6.43,-2.95,;4.92,-2.63,;3.68,-3.53,)| Show InChI InChI=1S/C21H23N3O2S/c1-2-6-19-18(5-1)24-21(27-19)23-15-12-16(13-15)26-20-17(4-3-9-22-20)14-7-10-25-11-8-14/h1-6,9,14-16H,7-8,10-13H2,(H,23,24)/t15-,16- | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 3.19 | n/a | n/a | n/a | n/a | n/a | 25 |
Amgen Inc.
US Patent
| Assay Description
Enzyme Activity. An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 uL, of serial diluted P... |
US Patent US8952037 (2015)
BindingDB Entry DOI: 10.7270/Q23X85CW |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM144717
(US8952037, 93)Show SMILES C[C@@H]1CCN(C1)c1nccnc1O[C@@H]1C[C@@H](C1)Nc1nc2ccccc2s1 |r,wU:1.0,wD:13.14,15.19,(-4.44,9.51,;-5.21,8.18,;-6.75,8.18,;-7.23,6.72,;-5.98,5.81,;-4.74,6.72,;-5.98,4.27,;-7.32,3.5,;-7.32,1.96,;-5.98,1.19,;-4.65,1.96,;-4.65,3.5,;-3.32,4.27,;-1.98,3.5,;-.5,3.9,;-.1,2.41,;-1.58,2.01,;1.24,1.64,;2.57,2.41,;2.73,3.94,;4.24,4.26,;5.01,5.6,;6.55,5.6,;7.32,4.26,;6.55,2.93,;5.01,2.93,;3.98,1.79,)| Show InChI InChI=1S/C20H23N5OS/c1-13-6-9-25(12-13)18-19(22-8-7-21-18)26-15-10-14(11-15)23-20-24-16-4-2-3-5-17(16)27-20/h2-5,7-8,13-15H,6,9-12H2,1H3,(H,23,24)/t13-,14-,15+/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 3.24 | n/a | n/a | n/a | n/a | n/a | 25 |
Amgen Inc.
US Patent
| Assay Description
Enzyme Activity. An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 uL, of serial diluted P... |
US Patent US8952037 (2015)
BindingDB Entry DOI: 10.7270/Q23X85CW |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM144673
(US8952037, 46)Show SMILES Cc1ncc(cn1)-c1nccnc1O[C@@H]1C[C@@H](C1)Nc1nc2ccccc2s1 |r,wU:16.20,14.15,(1.52,-6.38,;2.29,-5.05,;1.52,-3.71,;2.29,-2.38,;3.83,-2.38,;4.6,-3.71,;3.83,-5.05,;4.6,-1.05,;6.14,-1.05,;6.91,.29,;6.14,1.62,;4.6,1.62,;3.83,.29,;2.29,.29,;1.52,1.62,;1.92,3.11,;.43,3.51,;.04,2.02,;-.34,4.84,;-1.88,4.84,;-2.78,3.6,;-4.25,4.07,;-5.58,3.3,;-6.91,4.07,;-6.91,5.61,;-5.58,6.38,;-4.25,5.61,;-2.78,6.09,)| Show InChI InChI=1S/C20H18N6OS/c1-12-23-10-13(11-24-12)18-19(22-7-6-21-18)27-15-8-14(9-15)25-20-26-16-4-2-3-5-17(16)28-20/h2-7,10-11,14-15H,8-9H2,1H3,(H,25,26)/t14-,15+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 3.25 | n/a | n/a | n/a | n/a | n/a | 25 |
Amgen Inc.
US Patent
| Assay Description
Enzyme Activity. An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 uL, of serial diluted P... |
US Patent US8952037 (2015)
BindingDB Entry DOI: 10.7270/Q23X85CW |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM144671
(US8952037, 44)Show SMILES Cc1ccc(cn1)-c1nccnc1O[C@@H]1C[C@@H](C1)Nc1nc2ccccc2s1 |r,wU:14.15,16.20,(-5.98,4.62,;-5.98,3.08,;-4.65,2.31,;-4.65,.77,;-5.98,,;-7.32,.77,;-7.32,2.31,;-5.98,-1.54,;-7.32,-2.31,;-7.32,-3.85,;-5.98,-4.62,;-4.65,-3.85,;-4.65,-2.31,;-3.32,-1.54,;-1.98,-2.31,;-1.58,-3.8,;-.1,-3.4,;-.5,-1.91,;1.24,-4.17,;2.57,-3.4,;2.73,-1.87,;4.24,-1.55,;5.01,-.21,;6.55,-.21,;7.32,-1.55,;6.55,-2.88,;5.01,-2.88,;3.98,-4.03,)| Show InChI InChI=1S/C21H19N5OS/c1-13-6-7-14(12-24-13)19-20(23-9-8-22-19)27-16-10-15(11-16)25-21-26-17-4-2-3-5-18(17)28-21/h2-9,12,15-16H,10-11H2,1H3,(H,25,26)/t15-,16+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 3.39 | n/a | n/a | n/a | n/a | n/a | 25 |
Amgen Inc.
US Patent
| Assay Description
Enzyme Activity. An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 uL, of serial diluted P... |
US Patent US8952037 (2015)
BindingDB Entry DOI: 10.7270/Q23X85CW |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM144665
(US8952037, 38)Show SMILES Fc1ccc2sc(N[C@H]3C[C@H](C3)Oc3ncc(F)cc3C3CCOCC3)nc2c1 |r,wD:10.12,8.7,(7.98,1.89,;7.21,.56,;7.98,-.78,;7.21,-2.11,;5.67,-2.11,;4.64,-3.26,;3.24,-2.63,;1.9,-3.4,;.57,-2.63,;.17,-1.14,;-1.32,-1.54,;-.92,-3.03,;-2.65,-.77,;-3.98,-1.54,;-3.98,-3.08,;-5.32,-3.85,;-6.65,-3.08,;-7.98,-3.85,;-6.65,-1.54,;-5.32,-.77,;-5.32,.77,;-6.65,1.54,;-6.65,3.08,;-5.32,3.85,;-3.98,3.08,;-3.98,1.54,;3.4,-1.1,;4.9,-.78,;5.67,.56,)| Show InChI InChI=1S/C21H21F2N3O2S/c22-13-1-2-19-18(8-13)26-21(29-19)25-15-9-16(10-15)28-20-17(7-14(23)11-24-20)12-3-5-27-6-4-12/h1-2,7-8,11-12,15-16H,3-6,9-10H2,(H,25,26)/t15-,16+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 3.49 | n/a | n/a | n/a | n/a | n/a | 25 |
Amgen Inc.
US Patent
| Assay Description
Enzyme Activity. An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 uL, of serial diluted P... |
US Patent US8952037 (2015)
BindingDB Entry DOI: 10.7270/Q23X85CW |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM144668
(US8952037, 41)Show SMILES Clc1ccc(C2=CCOCC2)c(O[C@@H]2C[C@@H](C2)Nc2nc3ccccc3s2)n1 |r,wU:13.13,15.18,t:5,(-5.98,-4.62,;-5.98,-3.08,;-7.32,-2.31,;-7.32,-.77,;-5.98,,;-5.98,1.54,;-7.32,2.31,;-7.32,3.85,;-5.98,4.62,;-4.65,3.85,;-4.65,2.31,;-4.65,-.77,;-3.32,,;-1.98,-.77,;-1.58,-2.26,;-.1,-1.86,;-.5,-.37,;1.24,-2.63,;2.57,-1.86,;2.73,-.33,;4.24,-.01,;5.01,1.33,;6.55,1.33,;7.32,-.01,;6.55,-1.34,;5.01,-1.34,;3.98,-2.49,;-4.65,-2.31,)| Show InChI InChI=1S/C21H20ClN3O2S/c22-19-6-5-16(13-7-9-26-10-8-13)20(25-19)27-15-11-14(12-15)23-21-24-17-3-1-2-4-18(17)28-21/h1-7,14-15H,8-12H2,(H,23,24)/t14-,15+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 3.55 | n/a | n/a | n/a | n/a | n/a | 25 |
Amgen Inc.
US Patent
| Assay Description
Enzyme Activity. An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 uL, of serial diluted P... |
US Patent US8952037 (2015)
BindingDB Entry DOI: 10.7270/Q23X85CW |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM144705
(US8952037, 80)Show SMILES OCC1CCCN(C1)c1nccnc1O[C@@H]1C[C@@H](C1)Nc1nc2ccccc2s1 |r,wD:15.16,17.21,(-1.98,3.08,;-3.32,3.85,;-4.65,3.08,;-5.98,3.85,;-7.32,3.08,;-7.32,1.54,;-5.98,.77,;-4.65,1.54,;-5.98,-.77,;-7.32,-1.54,;-7.32,-3.08,;-5.98,-3.85,;-4.65,-3.08,;-4.65,-1.54,;-3.32,-.77,;-1.98,-1.54,;-.5,-1.14,;-.1,-2.63,;-1.58,-3.03,;1.24,-3.4,;2.57,-2.63,;2.73,-1.1,;4.24,-.78,;5.01,.56,;6.55,.56,;7.32,-.78,;6.55,-2.11,;5.01,-2.11,;3.98,-3.26,)| Show InChI InChI=1S/C21H25N5O2S/c27-13-14-4-3-9-26(12-14)19-20(23-8-7-22-19)28-16-10-15(11-16)24-21-25-17-5-1-2-6-18(17)29-21/h1-2,5-8,14-16,27H,3-4,9-13H2,(H,24,25)/t14?,15-,16+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 3.62 | n/a | n/a | n/a | n/a | n/a | 25 |
Amgen Inc.
US Patent
| Assay Description
Enzyme Activity. An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 uL, of serial diluted P... |
US Patent US8952037 (2015)
BindingDB Entry DOI: 10.7270/Q23X85CW |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM144688
(US8952037, 61)Show SMILES NC(=O)c1ccc(cn1)-c1nccnc1O[C@@H]1C[C@@H](C1)Nc1ccc2ccccc2n1 |r,wU:16.17,18.22,(-4.94,5,;-6.28,4.23,;-7.61,5,;-6.28,2.69,;-4.94,1.92,;-4.94,.38,;-6.28,-.39,;-7.61,.38,;-7.61,1.92,;-6.28,-1.93,;-7.61,-2.7,;-7.61,-4.24,;-6.28,-5.01,;-4.94,-4.24,;-4.94,-2.7,;-3.61,-1.93,;-2.28,-2.7,;-1.88,-4.18,;-.39,-3.78,;-.79,-2.3,;.94,-4.55,;2.28,-3.78,;2.28,-2.24,;3.61,-1.47,;4.94,-2.24,;6.28,-1.47,;7.61,-2.24,;7.61,-3.78,;6.28,-4.55,;4.94,-3.78,;3.61,-4.55,)| Show InChI InChI=1S/C23H20N6O2/c24-22(30)19-7-5-15(13-27-19)21-23(26-10-9-25-21)31-17-11-16(12-17)28-20-8-6-14-3-1-2-4-18(14)29-20/h1-10,13,16-17H,11-12H2,(H2,24,30)(H,28,29)/t16-,17+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
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antibodypedia
GoogleScholar
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| PC cid
PC sid
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| US Patent
| n/a | n/a | 3.80 | n/a | n/a | n/a | n/a | n/a | 25 |
Amgen Inc.
US Patent
| Assay Description
Enzyme Activity. An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 uL, of serial diluted P... |
US Patent US8952037 (2015)
BindingDB Entry DOI: 10.7270/Q23X85CW |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM144672
(US8952037, 45)Show SMILES COc1ncccc1-c1nccnc1O[C@@H]1C[C@@H](C1)Nc1nc2ccccc2s1 |r,wU:15.16,17.21,(-8.65,1.54,;-7.32,.77,;-5.98,1.54,;-5.98,3.08,;-4.65,3.85,;-3.32,3.08,;-3.32,1.54,;-4.65,.77,;-4.65,-.77,;-5.98,-1.54,;-5.98,-3.08,;-4.65,-3.85,;-3.32,-3.08,;-3.32,-1.54,;-1.98,-.77,;-.65,-1.54,;-.25,-3.03,;1.24,-2.63,;.84,-1.14,;2.57,-3.4,;3.9,-2.63,;4.07,-1.1,;5.57,-.78,;6.34,.56,;7.88,.56,;8.65,-.78,;7.88,-2.11,;6.34,-2.11,;5.31,-3.26,)| Show InChI InChI=1S/C21H19N5O2S/c1-27-19-15(5-4-8-23-19)18-20(24-10-9-22-18)28-14-11-13(12-14)25-21-26-16-6-2-3-7-17(16)29-21/h2-10,13-14H,11-12H2,1H3,(H,25,26)/t13-,14+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
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Similars
| US Patent
| n/a | n/a | 4.11 | n/a | n/a | n/a | n/a | n/a | 25 |
Amgen Inc.
US Patent
| Assay Description
Enzyme Activity. An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 uL, of serial diluted P... |
US Patent US8952037 (2015)
BindingDB Entry DOI: 10.7270/Q23X85CW |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM144669
(US8952037, 42)Show SMILES Cc1cnccc1-c1nccnc1O[C@@H]1C[C@@H](C1)Nc1nc2ccccc2s1 |r,wD:14.15,16.20,(-3.32,.77,;-4.65,1.54,;-4.65,3.08,;-5.98,3.85,;-7.32,3.08,;-7.32,1.54,;-5.98,.77,;-5.98,-.77,;-7.32,-1.54,;-7.32,-3.08,;-5.98,-3.85,;-4.65,-3.08,;-4.65,-1.54,;-3.32,-.77,;-1.98,-1.54,;-.5,-1.14,;-.1,-2.63,;-1.58,-3.03,;1.24,-3.4,;2.57,-2.63,;2.73,-1.1,;4.24,-.78,;5.01,.56,;6.55,.56,;7.32,-.78,;6.55,-2.11,;5.01,-2.11,;3.98,-3.26,)| Show InChI InChI=1S/C21H19N5OS/c1-13-12-22-7-6-16(13)19-20(24-9-8-23-19)27-15-10-14(11-15)25-21-26-17-4-2-3-5-18(17)28-21/h2-9,12,14-15H,10-11H2,1H3,(H,25,26)/t14-,15+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 4.23 | n/a | n/a | n/a | n/a | n/a | 25 |
Amgen Inc.
US Patent
| Assay Description
Enzyme Activity. An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 uL, of serial diluted P... |
US Patent US8952037 (2015)
BindingDB Entry DOI: 10.7270/Q23X85CW |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM47126
(US8952027, 64)Show SMILES COC(=O)N1CCC(CC1)c1nccnc1O[C@@H]1C[C@@H](C1)Nc1nc2ccccc2s1 |r,wD:19.23,17.18,(-.43,-2.36,;-1.77,-1.59,;-3.1,-2.36,;-4.43,-1.59,;-3.1,-3.9,;-1.77,-4.67,;-1.77,-6.21,;-3.1,-6.98,;-4.43,-6.21,;-4.43,-4.67,;-3.1,-8.52,;-4.43,-9.29,;-4.43,-10.83,;-3.1,-11.59,;-1.77,-10.83,;-1.77,-9.29,;-.43,-8.52,;.9,-9.29,;2.39,-8.89,;2.79,-10.37,;1.3,-10.77,;4.12,-11.14,;5.45,-10.37,;5.62,-8.84,;7.13,-8.53,;7.9,-7.19,;9.44,-7.2,;10.21,-8.53,;9.43,-9.86,;7.89,-9.86,;6.86,-11,)| Show InChI InChI=1S/C22H25N5O3S/c1-29-22(28)27-10-6-14(7-11-27)19-20(24-9-8-23-19)30-16-12-15(13-16)25-21-26-17-4-2-3-5-18(17)31-21/h2-5,8-9,14-16H,6-7,10-13H2,1H3,(H,25,26)/t15-,16+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 4.24 | n/a | n/a | n/a | n/a | n/a | 25 |
Amgen Inc.
US Patent
| Assay Description
Enzyme Activity. An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 uL, of serial diluted P... |
US Patent US8952037 (2015)
BindingDB Entry DOI: 10.7270/Q23X85CW |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM144694
(US8952037, 67)Show SMILES CC(=O)N1CCC(CC1)c1nccnc1O[C@@H]1C[C@@H](C1)Nc1ccc2ccccc2n1 |r,wD:16.17,18.22,(-4.94,5,;-6.28,4.23,;-7.61,5,;-6.28,2.69,;-7.61,1.92,;-7.61,.38,;-6.28,-.39,;-4.94,.38,;-4.94,1.92,;-6.28,-1.93,;-7.61,-2.7,;-7.61,-4.24,;-6.28,-5.01,;-4.94,-4.24,;-4.94,-2.7,;-3.61,-1.93,;-2.28,-2.7,;-.79,-2.3,;-.39,-3.78,;-1.88,-4.18,;.94,-4.55,;2.28,-3.78,;2.28,-2.24,;3.61,-1.47,;4.94,-2.24,;6.28,-1.47,;7.61,-2.24,;7.61,-3.78,;6.28,-4.55,;4.94,-3.78,;3.61,-4.55,)| Show InChI InChI=1S/C24H27N5O2/c1-16(30)29-12-8-18(9-13-29)23-24(26-11-10-25-23)31-20-14-19(15-20)27-22-7-6-17-4-2-3-5-21(17)28-22/h2-7,10-11,18-20H,8-9,12-15H2,1H3,(H,27,28)/t19-,20+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 4.93 | n/a | n/a | n/a | n/a | n/a | 25 |
Amgen Inc.
US Patent
| Assay Description
Enzyme Activity. An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 uL, of serial diluted P... |
US Patent US8952037 (2015)
BindingDB Entry DOI: 10.7270/Q23X85CW |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM144695
(US8952037, 68)Show SMILES COCC(=O)N1CCC(CC1)c1nccnc1O[C@@H]1C[C@@H](C1)Nc1ccc2ccccc2n1 |r,wD:18.19,20.24,(-2.28,5,;-3.61,4.23,;-4.94,5,;-6.28,4.23,;-7.61,5,;-6.28,2.69,;-7.61,1.92,;-7.61,.38,;-6.28,-.39,;-4.94,.38,;-4.94,1.92,;-6.28,-1.93,;-7.61,-2.7,;-7.61,-4.24,;-6.28,-5.01,;-4.94,-4.24,;-4.94,-2.7,;-3.61,-1.93,;-2.28,-2.7,;-.79,-2.3,;-.39,-3.78,;-1.88,-4.18,;.94,-4.55,;2.28,-3.78,;2.28,-2.24,;3.61,-1.47,;4.94,-2.24,;6.28,-1.47,;7.61,-2.24,;7.61,-3.78,;6.28,-4.55,;4.94,-3.78,;3.61,-4.55,)| Show InChI InChI=1S/C25H29N5O3/c1-32-16-23(31)30-12-8-18(9-13-30)24-25(27-11-10-26-24)33-20-14-19(15-20)28-22-7-6-17-4-2-3-5-21(17)29-22/h2-7,10-11,18-20H,8-9,12-16H2,1H3,(H,28,29)/t19-,20+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 5.06 | n/a | n/a | n/a | n/a | n/a | 25 |
Amgen Inc.
US Patent
| Assay Description
Enzyme Activity. An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 uL, of serial diluted P... |
US Patent US8952037 (2015)
BindingDB Entry DOI: 10.7270/Q23X85CW |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM144733
(US8952037, 96)Show SMILES N#C[C@H]1CCN(C1)c1nccnc1O[C@@H]1C[C@@H](C1)Nc1nc2ccccc2s1 |r,wD:14.15,16.20,2.1,(-3.42,10.22,;-4.31,8.96,;-5.19,7.7,;-6.75,7.61,;-7.23,6.15,;-5.98,5.24,;-4.74,6.15,;-5.98,3.7,;-7.32,2.93,;-7.32,1.39,;-5.98,.62,;-4.65,1.39,;-4.65,2.93,;-3.32,3.7,;-1.98,2.93,;-.5,3.33,;-.1,1.84,;-1.58,1.44,;1.24,1.07,;2.57,1.84,;2.73,3.37,;4.24,3.69,;5.01,5.03,;6.55,5.03,;7.32,3.69,;6.55,2.36,;5.01,2.36,;3.98,1.22,)| Show InChI InChI=1S/C20H20N6OS/c21-11-13-5-8-26(12-13)18-19(23-7-6-22-18)27-15-9-14(10-15)24-20-25-16-3-1-2-4-17(16)28-20/h1-4,6-7,13-15H,5,8-10,12H2,(H,24,25)/t13-,14-,15+/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 5.27 | n/a | n/a | n/a | n/a | n/a | 25 |
Amgen Inc.
US Patent
| Assay Description
Enzyme Activity. An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 uL, of serial diluted P... |
US Patent US8952037 (2015)
BindingDB Entry DOI: 10.7270/Q23X85CW |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM144664
(US8952037, 37)Show SMILES Fc1cnc(O[C@@H]2C[C@@H](C2)Nc2nc3c(F)cccc3s2)c(c1)C1CCOCC1 |r,wD:6.5,8.10,(-7.98,-3.85,;-6.65,-3.08,;-5.32,-3.85,;-3.98,-3.08,;-3.98,-1.54,;-2.65,-.77,;-1.32,-1.54,;.17,-1.14,;.57,-2.63,;-.92,-3.03,;1.9,-3.4,;3.24,-2.63,;3.4,-1.1,;4.9,-.78,;5.67,.56,;4.9,1.89,;7.21,.56,;7.98,-.78,;7.21,-2.11,;5.67,-2.11,;4.64,-3.26,;-5.32,-.77,;-6.65,-1.54,;-5.32,.77,;-6.65,1.54,;-6.65,3.08,;-5.32,3.85,;-3.98,3.08,;-3.98,1.54,)| Show InChI InChI=1S/C21H21F2N3O2S/c22-13-8-16(12-4-6-27-7-5-12)20(24-11-13)28-15-9-14(10-15)25-21-26-19-17(23)2-1-3-18(19)29-21/h1-3,8,11-12,14-15H,4-7,9-10H2,(H,25,26)/t14-,15+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 5.43 | n/a | n/a | n/a | n/a | n/a | 25 |
Amgen Inc.
US Patent
| Assay Description
Enzyme Activity. An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 uL, of serial diluted P... |
US Patent US8952037 (2015)
BindingDB Entry DOI: 10.7270/Q23X85CW |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM144692
(US8952037, 65)Show SMILES COCC(=O)N1CCC(CC1)c1nccnc1O[C@@H]1C[C@@H](C1)Nc1nc2ccccc2s1 |r,wD:18.19,20.24,(-1.56,5.77,;-2.89,5,;-4.22,5.77,;-5.56,5,;-6.65,6.09,;-5.56,3.46,;-6.89,2.69,;-6.89,1.15,;-5.56,.38,;-4.22,1.15,;-4.22,2.69,;-5.56,-1.16,;-6.89,-1.93,;-6.89,-3.47,;-5.56,-4.24,;-4.22,-3.47,;-4.22,-1.93,;-2.89,-1.16,;-1.8,-2.24,;-.26,-2.24,;-.26,-3.78,;-1.8,-3.78,;.83,-4.87,;2.16,-4.1,;2.32,-2.57,;3.83,-2.25,;4.6,-.92,;6.14,-.92,;6.91,-2.25,;6.14,-3.58,;4.6,-3.58,;3.57,-4.73,)| Show InChI InChI=1S/C23H27N5O3S/c1-30-14-20(29)28-10-6-15(7-11-28)21-22(25-9-8-24-21)31-17-12-16(13-17)26-23-27-18-4-2-3-5-19(18)32-23/h2-5,8-9,15-17H,6-7,10-14H2,1H3,(H,26,27)/t16-,17+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 6.57 | n/a | n/a | n/a | n/a | n/a | 25 |
Amgen Inc.
US Patent
| Assay Description
Enzyme Activity. An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 uL, of serial diluted P... |
US Patent US8952037 (2015)
BindingDB Entry DOI: 10.7270/Q23X85CW |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM144702
(US8952037, 77)Show SMILES CC1CCN(C1)c1nccnc1O[C@@H]1C[C@@H](C1)Nc1nc2ccccc2s1 |r,wD:13.14,15.19,(-4.44,4.16,;-5.21,2.83,;-6.75,2.83,;-7.23,1.36,;-5.98,.46,;-4.74,1.36,;-5.98,-1.08,;-7.32,-1.85,;-7.32,-3.39,;-5.98,-4.16,;-4.65,-3.39,;-4.65,-1.85,;-3.32,-1.08,;-1.98,-1.85,;-.5,-1.45,;-.1,-2.94,;-1.58,-3.34,;1.24,-3.71,;2.57,-2.94,;2.73,-1.41,;4.24,-1.09,;5.01,.24,;6.55,.24,;7.32,-1.09,;6.55,-2.42,;5.01,-2.42,;3.98,-3.57,)| Show InChI InChI=1S/C20H23N5OS/c1-13-6-9-25(12-13)18-19(22-8-7-21-18)26-15-10-14(11-15)23-20-24-16-4-2-3-5-17(16)27-20/h2-5,7-8,13-15H,6,9-12H2,1H3,(H,23,24)/t13?,14-,15+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 6.92 | n/a | n/a | n/a | n/a | n/a | 25 |
Amgen Inc.
US Patent
| Assay Description
Enzyme Activity. An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 uL, of serial diluted P... |
US Patent US8952037 (2015)
BindingDB Entry DOI: 10.7270/Q23X85CW |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM144708
(US8952037, 83)Show SMILES C1[C@@H](C[C@@H]1Oc1nccnc1N1CCn2cncc2C1)Nc1nc2ccccc2s1 |r,wD:3.4,1.23,(-.5,-1.98,;-.1,-3.46,;-1.58,-3.86,;-1.98,-2.37,;-3.32,-1.6,;-4.65,-2.37,;-4.65,-3.91,;-5.98,-4.68,;-7.32,-3.91,;-7.32,-2.37,;-5.98,-1.6,;-5.98,-.06,;-7.32,.71,;-7.32,2.25,;-5.98,3.02,;-5.66,4.52,;-4.13,4.68,;-3.51,3.28,;-4.65,2.25,;-4.65,.71,;1.24,-4.23,;2.57,-3.46,;2.73,-1.93,;4.24,-1.61,;5.01,-.28,;6.55,-.28,;7.32,-1.61,;6.55,-2.94,;5.01,-2.94,;3.98,-4.09,)| Show InChI InChI=1S/C21H21N7OS/c1-2-4-18-17(3-1)26-21(30-18)25-14-9-16(10-14)29-20-19(23-5-6-24-20)27-7-8-28-13-22-11-15(28)12-27/h1-6,11,13-14,16H,7-10,12H2,(H,25,26)/t14-,16+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 6.99 | n/a | n/a | n/a | n/a | n/a | 25 |
Amgen Inc.
US Patent
| Assay Description
Enzyme Activity. An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 uL, of serial diluted P... |
US Patent US8952037 (2015)
BindingDB Entry DOI: 10.7270/Q23X85CW |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM144649
(US8952037, 16)Show SMILES O=C([C@H]1CC(C1)Oc1ncccc1C1CCOCC1)c1nc2ccccc2[nH]1 |r,wU:2.1,(1.24,-4.39,;1.24,-2.85,;-.1,-2.08,;-1.58,-2.48,;-1.98,-1,;-.5,-.6,;-3.32,-.23,;-4.65,-1,;-4.65,-2.54,;-5.98,-3.31,;-7.32,-2.54,;-7.32,-1,;-5.98,-.23,;-5.98,1.31,;-4.65,2.08,;-4.65,3.62,;-5.98,4.39,;-7.32,3.62,;-7.32,2.08,;2.57,-2.08,;2.73,-.55,;4.24,-.23,;5.01,1.1,;6.55,1.1,;7.32,-.23,;6.55,-1.57,;5.01,-1.57,;3.98,-2.71,)| | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
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antibodypedia
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| PC cid
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| n/a | n/a | 7.15 | n/a | n/a | n/a | n/a | n/a | 25 |
Amgen Inc.
US Patent
| Assay Description
Enzyme Activity. An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 uL, of serial diluted P... |
US Patent US8952037 (2015)
BindingDB Entry DOI: 10.7270/Q23X85CW |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM144675
(US8952037, 48)Show SMILES N#Cc1ccc(cn1)-c1nccnc1O[C@@H]1C[C@@H](C1)Nc1nc2ccccc2s1 |r,wD:15.16,17.21,(-5.98,5.39,;-5.98,3.85,;-5.98,2.31,;-4.65,1.54,;-4.65,,;-5.98,-.77,;-7.32,,;-7.32,1.54,;-5.98,-2.31,;-7.32,-3.08,;-7.32,-4.62,;-5.98,-5.39,;-4.65,-4.62,;-4.65,-3.08,;-3.32,-2.31,;-1.98,-3.08,;-.5,-2.68,;-.1,-4.17,;-1.58,-4.57,;1.24,-4.94,;2.57,-4.17,;2.73,-2.64,;4.24,-2.32,;5.01,-.98,;6.55,-.98,;7.32,-2.32,;6.55,-3.65,;5.01,-3.65,;3.98,-4.8,)| Show InChI InChI=1S/C21H16N6OS/c22-11-14-6-5-13(12-25-14)19-20(24-8-7-23-19)28-16-9-15(10-16)26-21-27-17-3-1-2-4-18(17)29-21/h1-8,12,15-16H,9-10H2,(H,26,27)/t15-,16+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
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| PC cid
PC sid
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Similars
| US Patent
| n/a | n/a | 7.40 | n/a | n/a | n/a | n/a | n/a | 25 |
Amgen Inc.
US Patent
| Assay Description
Enzyme Activity. An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 uL, of serial diluted P... |
US Patent US8952037 (2015)
BindingDB Entry DOI: 10.7270/Q23X85CW |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM144730
(US8952037, 113)Show SMILES C1[C@@H](C[C@@H]1Oc1nccnc1C1CCOCC1)Nc1ccc2ccccc2n1 |r,wD:3.4,1.19,(-.79,-1.14,;-.39,-2.63,;-1.88,-3.03,;-2.28,-1.54,;-3.61,-.77,;-4.94,-1.54,;-4.94,-3.08,;-6.28,-3.85,;-7.61,-3.08,;-7.61,-1.54,;-6.28,-.77,;-6.28,.77,;-4.94,1.54,;-4.94,3.08,;-6.28,3.85,;-7.61,3.08,;-7.61,1.54,;.94,-3.4,;2.28,-2.63,;2.28,-1.09,;3.61,-.32,;4.94,-1.09,;6.28,-.32,;7.61,-1.09,;7.61,-2.63,;6.28,-3.4,;4.94,-2.63,;3.61,-3.4,)| Show InChI InChI=1S/C22H24N4O2/c1-2-4-19-15(3-1)5-6-20(26-19)25-17-13-18(14-17)28-22-21(23-9-10-24-22)16-7-11-27-12-8-16/h1-6,9-10,16-18H,7-8,11-14H2,(H,25,26)/t17-,18+ | PDB
MMDB
Reactome pathway
KEGG
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B.MOAD
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antibodypedia
GoogleScholar
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| PC cid
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UniChem
Similars
| US Patent
| n/a | n/a | 7.5 | n/a | n/a | n/a | n/a | n/a | 25 |
Amgen Inc.
US Patent
| Assay Description
Enzyme Activity. An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 uL, of serial diluted P... |
US Patent US8952037 (2015)
BindingDB Entry DOI: 10.7270/Q23X85CW |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM144674
(US8952037, 47)Show SMILES Clc1ccc(cn1)-c1nccnc1O[C@@H]1C[C@@H](C1)Nc1nc2ccccc2s1 |r,wD:14.15,16.20,(-5.98,4.62,;-5.98,3.08,;-4.65,2.31,;-4.65,.77,;-5.98,,;-7.32,.77,;-7.32,2.31,;-5.98,-1.54,;-7.32,-2.31,;-7.32,-3.85,;-5.98,-4.62,;-4.65,-3.85,;-4.65,-2.31,;-3.32,-1.54,;-1.98,-2.31,;-.5,-1.91,;-.1,-3.4,;-1.58,-3.8,;1.24,-4.17,;2.57,-3.4,;2.73,-1.87,;4.24,-1.55,;5.01,-.21,;6.55,-.21,;7.32,-1.55,;6.55,-2.88,;5.01,-2.88,;3.98,-4.03,)| Show InChI InChI=1S/C20H16ClN5OS/c21-17-6-5-12(11-24-17)18-19(23-8-7-22-18)27-14-9-13(10-14)25-20-26-15-3-1-2-4-16(15)28-20/h1-8,11,13-14H,9-10H2,(H,25,26)/t13-,14+ | PDB
MMDB
Reactome pathway
KEGG
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antibodypedia
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| PC cid
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| US Patent
| n/a | n/a | 7.66 | n/a | n/a | n/a | n/a | n/a | 25 |
Amgen Inc.
US Patent
| Assay Description
Enzyme Activity. An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 uL, of serial diluted P... |
US Patent US8952037 (2015)
BindingDB Entry DOI: 10.7270/Q23X85CW |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM144681
(US8952037, 54)Show SMILES N#Cc1ccc(cn1)-c1nccnc1O[C@@H]1C[C@@H](C1)Nc1ncc2ccccc2n1 |r,wD:15.16,17.21,(-6.28,5.45,;-6.28,3.91,;-6.28,2.37,;-4.94,1.54,;-4.94,,;-6.28,-.77,;-7.61,,;-7.61,1.54,;-6.28,-2.31,;-7.61,-3.08,;-7.61,-4.62,;-6.28,-5.39,;-4.94,-4.62,;-4.94,-3.08,;-3.61,-2.31,;-2.28,-3.08,;-.79,-2.68,;-.39,-4.17,;-1.88,-4.57,;.94,-4.94,;2.28,-4.17,;2.28,-2.63,;3.61,-1.86,;4.94,-2.63,;6.28,-1.86,;7.61,-2.63,;7.61,-4.17,;6.28,-4.94,;4.94,-4.17,;3.61,-4.94,)| Show InChI InChI=1S/C22H17N7O/c23-11-16-6-5-15(13-26-16)20-21(25-8-7-24-20)30-18-9-17(10-18)28-22-27-12-14-3-1-2-4-19(14)29-22/h1-8,12-13,17-18H,9-10H2,(H,27,28,29)/t17-,18+ | PDB
MMDB
Reactome pathway
KEGG
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B.MOAD
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antibodypedia
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AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 7.71 | n/a | n/a | n/a | n/a | n/a | 25 |
Amgen Inc.
US Patent
| Assay Description
Enzyme Activity. An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 uL, of serial diluted P... |
US Patent US8952037 (2015)
BindingDB Entry DOI: 10.7270/Q23X85CW |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM144732
(US8952037, 94)Show SMILES C[C@H]1CCN(C1)c1nccnc1O[C@@H]1C[C@@H](C1)Nc1nc2ccccc2s1 |r,wD:13.14,15.19,1.0,(-4.44,9.51,;-5.21,8.18,;-6.75,8.18,;-7.23,6.72,;-5.98,5.81,;-4.74,6.72,;-5.98,4.27,;-7.32,3.5,;-7.32,1.96,;-5.98,1.19,;-4.65,1.96,;-4.65,3.5,;-3.32,4.27,;-1.98,3.5,;-.5,3.9,;-.1,2.41,;-1.58,2.01,;1.24,1.64,;2.57,2.41,;2.73,3.94,;4.24,4.26,;5.01,5.6,;6.55,5.6,;7.32,4.26,;6.55,2.93,;5.01,2.93,;3.98,1.79,)| Show InChI InChI=1S/C20H23N5OS/c1-13-6-9-25(12-13)18-19(22-8-7-21-18)26-15-10-14(11-15)23-20-24-16-4-2-3-5-17(16)27-20/h2-5,7-8,13-15H,6,9-12H2,1H3,(H,23,24)/t13-,14-,15+/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
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antibodypedia
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| PC cid
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Similars
| US Patent
| n/a | n/a | 8.02 | n/a | n/a | n/a | n/a | n/a | 25 |
Amgen Inc.
US Patent
| Assay Description
Enzyme Activity. An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 uL, of serial diluted P... |
US Patent US8952037 (2015)
BindingDB Entry DOI: 10.7270/Q23X85CW |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM144646
(US8952037, 13)Show SMILES Cc1ccc(N[C@H]2C[C@H](C2)Oc2ncccc2C2CCOCC2)nc1 |r,wU:8.10,6.5,(6.94,-.32,;5.61,-1.09,;4.28,-.32,;2.94,-1.09,;2.94,-2.63,;1.61,-3.4,;.28,-2.63,;-1.21,-3.03,;-1.61,-1.54,;-.12,-1.14,;-2.94,-.77,;-4.28,-1.54,;-4.28,-3.08,;-5.61,-3.85,;-6.94,-3.08,;-6.94,-1.54,;-5.61,-.77,;-5.61,.77,;-4.28,1.54,;-4.28,3.08,;-5.61,3.85,;-6.94,3.08,;-6.94,1.54,;4.28,-3.4,;5.61,-2.63,)| Show InChI InChI=1S/C20H25N3O2/c1-14-4-5-19(22-13-14)23-16-11-17(12-16)25-20-18(3-2-8-21-20)15-6-9-24-10-7-15/h2-5,8,13,15-17H,6-7,9-12H2,1H3,(H,22,23)/t16-,17+ | PDB
MMDB
Reactome pathway
KEGG
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antibodypedia
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| PC cid
PC sid
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Similars
| US Patent
| n/a | n/a | 8.25 | n/a | n/a | n/a | n/a | n/a | 25 |
Amgen Inc.
US Patent
| Assay Description
Enzyme Activity. An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 uL, of serial diluted P... |
US Patent US8952037 (2015)
BindingDB Entry DOI: 10.7270/Q23X85CW |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM144679
(US8952037, 52)Show SMILES N#Cc1ccc(cn1)-c1nccnc1O[C@@H]1C[C@@H](C1)Nc1ccc2ccccc2n1 |r,wD:15.16,17.21,(-6.28,5.39,;-6.28,3.85,;-6.28,2.31,;-4.94,1.54,;-4.94,,;-6.28,-.77,;-7.61,,;-7.61,1.54,;-6.28,-2.31,;-7.61,-3.08,;-7.61,-4.62,;-6.28,-5.39,;-4.94,-4.62,;-4.94,-3.08,;-3.61,-2.31,;-2.28,-3.08,;-.79,-2.68,;-.39,-4.17,;-1.88,-4.57,;.94,-4.94,;2.28,-4.17,;2.28,-2.63,;3.61,-1.86,;4.94,-2.63,;6.28,-1.86,;7.61,-2.63,;7.61,-4.17,;6.28,-4.94,;4.94,-4.17,;3.61,-4.94,)| Show InChI InChI=1S/C23H18N6O/c24-13-17-7-5-16(14-27-17)22-23(26-10-9-25-22)30-19-11-18(12-19)28-21-8-6-15-3-1-2-4-20(15)29-21/h1-10,14,18-19H,11-12H2,(H,28,29)/t18-,19+ | PDB
MMDB
Reactome pathway
KEGG
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B.MOAD
DrugBank
antibodypedia
GoogleScholar
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| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 8.35 | n/a | n/a | n/a | n/a | n/a | 25 |
Amgen Inc.
US Patent
| Assay Description
Enzyme Activity. An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 uL, of serial diluted P... |
US Patent US8952037 (2015)
BindingDB Entry DOI: 10.7270/Q23X85CW |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM144719
(US8952037, 100)Show SMILES CC(=O)N1CCN(CC1)c1nccnc1O[C@@H]1C[C@@H](C1)Nc1nc2ccccc2s1 |r,wD:16.17,18.22,(-4.43,-4.14,;-3.1,-4.91,;-1.76,-4.14,;-3.1,-6.45,;-1.76,-7.22,;-1.76,-8.76,;-3.1,-9.53,;-4.43,-8.76,;-4.43,-7.22,;-3.1,-11.07,;-4.43,-11.84,;-4.43,-13.38,;-3.1,-14.15,;-1.76,-13.38,;-1.76,-11.84,;-.43,-11.07,;.9,-11.84,;2.39,-11.44,;2.79,-12.93,;1.3,-13.33,;4.12,-13.7,;5.46,-12.93,;5.62,-11.4,;7.13,-11.08,;7.9,-9.75,;9.44,-9.75,;10.21,-11.08,;9.44,-12.41,;7.9,-12.41,;6.86,-13.56,)| Show InChI InChI=1S/C21H24N6O2S/c1-14(28)26-8-10-27(11-9-26)19-20(23-7-6-22-19)29-16-12-15(13-16)24-21-25-17-4-2-3-5-18(17)30-21/h2-7,15-16H,8-13H2,1H3,(H,24,25)/t15-,16+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
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| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 9.26 | n/a | n/a | n/a | n/a | n/a | 25 |
Amgen Inc.
US Patent
| Assay Description
Enzyme Activity. An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 uL, of serial diluted P... |
US Patent US8952037 (2015)
BindingDB Entry DOI: 10.7270/Q23X85CW |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM144715
(US8952037, 90)Show SMILES OCC1CCN(CC1)c1nccnc1O[C@@H]1C[C@@H](C1)Nc1ncc2ccccc2n1 |r,wD:15.16,17.21,(-7.61,5,;-6.28,4.23,;-6.28,2.69,;-4.94,1.93,;-4.94,.38,;-6.28,-.38,;-7.61,.38,;-7.61,1.93,;-6.28,-1.93,;-7.61,-2.69,;-7.61,-4.23,;-6.28,-5,;-4.94,-4.23,;-4.94,-2.69,;-3.61,-1.93,;-2.28,-2.69,;-.79,-2.3,;-.39,-3.78,;-1.88,-4.18,;.94,-4.55,;2.28,-3.78,;2.28,-2.24,;3.61,-1.47,;4.94,-2.24,;6.28,-1.47,;7.61,-2.24,;7.61,-3.78,;6.28,-4.55,;4.94,-3.78,;3.61,-4.55,)| Show InChI InChI=1S/C22H26N6O2/c29-14-15-5-9-28(10-6-15)20-21(24-8-7-23-20)30-18-11-17(12-18)26-22-25-13-16-3-1-2-4-19(16)27-22/h1-4,7-8,13,15,17-18,29H,5-6,9-12,14H2,(H,25,26,27)/t17-,18+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
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| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 10.9 | n/a | n/a | n/a | n/a | n/a | 25 |
Amgen Inc.
US Patent
| Assay Description
Enzyme Activity. An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 uL, of serial diluted P... |
US Patent US8952037 (2015)
BindingDB Entry DOI: 10.7270/Q23X85CW |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM144706
(US8952037, 81)Show SMILES FC1(F)CCN(C1)c1nccnc1O[C@@H]1C[C@@H](C1)Nc1nc2ccccc2s1 |r,wD:14.15,16.20,(-5.21,4.26,;-5.21,2.72,;-3.88,3.49,;-6.75,2.72,;-7.23,1.26,;-5.98,.36,;-4.74,1.26,;-5.98,-1.18,;-7.32,-1.95,;-7.32,-3.49,;-5.98,-4.26,;-4.65,-3.49,;-4.65,-1.95,;-3.32,-1.18,;-1.98,-1.95,;-.5,-1.56,;-.1,-3.04,;-1.58,-3.44,;1.24,-3.81,;2.57,-3.04,;2.73,-1.51,;4.24,-1.19,;5.01,.14,;6.55,.14,;7.32,-1.19,;6.55,-2.53,;5.01,-2.53,;3.98,-3.67,)| Show InChI InChI=1S/C19H19F2N5OS/c20-19(21)5-8-26(11-19)16-17(23-7-6-22-16)27-13-9-12(10-13)24-18-25-14-3-1-2-4-15(14)28-18/h1-4,6-7,12-13H,5,8-11H2,(H,24,25)/t12-,13+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 11.1 | n/a | n/a | n/a | n/a | n/a | 25 |
Amgen Inc.
US Patent
| Assay Description
Enzyme Activity. An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 uL, of serial diluted P... |
US Patent US8952037 (2015)
BindingDB Entry DOI: 10.7270/Q23X85CW |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM144643
(US8952037, 10)Show SMILES C1CC(CCO1)c1cccnc1O[C@H]1CC[C@@H](CC1)Nc1nc2ccccc2o1 |r,wU:16.21,wD:13.14,(-5.04,3.08,;-5.04,1.54,;-6.37,.77,;-7.71,1.54,;-7.71,3.08,;-6.37,3.85,;-6.37,-.77,;-7.71,-1.54,;-7.71,-3.08,;-6.37,-3.85,;-5.04,-3.08,;-5.04,-1.54,;-3.71,-.77,;-2.37,-1.54,;-2.37,-3.08,;-1.04,-3.85,;.29,-3.08,;.29,-1.54,;-1.04,-.77,;1.63,-3.85,;2.96,-3.08,;3.12,-1.55,;4.63,-1.23,;5.4,.11,;6.94,.11,;7.71,-1.23,;6.94,-2.56,;5.4,-2.56,;4.37,-3.71,)| Show InChI InChI=1S/C23H27N3O3/c1-2-6-21-20(5-1)26-23(29-21)25-17-7-9-18(10-8-17)28-22-19(4-3-13-24-22)16-11-14-27-15-12-16/h1-6,13,16-18H,7-12,14-15H2,(H,25,26)/t17-,18- | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 12 | n/a | n/a | n/a | n/a | n/a | 25 |
Amgen Inc.
US Patent
| Assay Description
Enzyme Activity. An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 uL, of serial diluted P... |
US Patent US8952037 (2015)
BindingDB Entry DOI: 10.7270/Q23X85CW |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM144660
(US8952037, 33)Show SMILES Fc1cccc2sc(N[C@H]3C[C@H](C3)Oc3nccnc3C3CCOCC3)nc12 |r,wD:11.13,9.8,(4.24,1.89,;5.01,.56,;6.55,.56,;7.32,-.78,;6.55,-2.11,;5.01,-2.11,;3.98,-3.26,;2.57,-2.63,;1.24,-3.4,;-.1,-2.63,;-.5,-1.14,;-1.98,-1.54,;-1.58,-3.03,;-3.32,-.77,;-4.65,-1.54,;-4.65,-3.08,;-5.98,-3.85,;-7.32,-3.08,;-7.32,-1.54,;-5.98,-.77,;-5.98,.77,;-7.32,1.54,;-7.32,3.08,;-5.98,3.85,;-4.65,3.08,;-4.65,1.54,;2.73,-1.1,;4.24,-.78,)| Show InChI InChI=1S/C20H21FN4O2S/c21-15-2-1-3-16-18(15)25-20(28-16)24-13-10-14(11-13)27-19-17(22-6-7-23-19)12-4-8-26-9-5-12/h1-3,6-7,12-14H,4-5,8-11H2,(H,24,25)/t13-,14+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 13 | n/a | n/a | n/a | n/a | n/a | 25 |
Amgen Inc.
US Patent
| Assay Description
Enzyme Activity. An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 uL, of serial diluted P... |
US Patent US8952037 (2015)
BindingDB Entry DOI: 10.7270/Q23X85CW |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM144709
(US8952037, 84)Show SMILES O[C@@H]1CCN(C1)c1nccnc1O[C@@H]1C[C@@H](C1)Nc1nc2ccccc2s1 |r,wU:1.0,wD:13.14,15.19,(-4.44,4.16,;-5.21,2.83,;-6.75,2.83,;-7.23,1.36,;-5.98,.46,;-4.74,1.36,;-5.98,-1.08,;-7.32,-1.85,;-7.32,-3.39,;-5.98,-4.16,;-4.65,-3.39,;-4.65,-1.85,;-3.32,-1.08,;-1.98,-1.85,;-.5,-1.45,;-.1,-2.94,;-1.58,-3.34,;1.24,-3.71,;2.57,-2.94,;2.73,-1.41,;4.24,-1.09,;5.01,.24,;6.55,.24,;7.32,-1.09,;6.55,-2.42,;5.01,-2.42,;3.98,-3.57,)| Show InChI InChI=1S/C19H21N5O2S/c25-13-5-8-24(11-13)17-18(21-7-6-20-17)26-14-9-12(10-14)22-19-23-15-3-1-2-4-16(15)27-19/h1-4,6-7,12-14,25H,5,8-11H2,(H,22,23)/t12-,13-,14+/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 14.2 | n/a | n/a | n/a | n/a | n/a | 25 |
Amgen Inc.
US Patent
| Assay Description
Enzyme Activity. An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 uL, of serial diluted P... |
US Patent US8952037 (2015)
BindingDB Entry DOI: 10.7270/Q23X85CW |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM144662
(US8952037, 35)Show SMILES Fc1ccc2nc(N[C@H]3C[C@H](C3)Oc3nccnc3C3CCOCC3)sc2c1 |r,wU:10.12,8.7,(8.09,-.78,;6.55,-.78,;5.78,.56,;4.24,.56,;3.47,-.78,;1.96,-1.1,;1.8,-2.63,;.47,-3.4,;-.87,-2.63,;-2.35,-3.03,;-2.75,-1.54,;-1.27,-1.14,;-4.09,-.77,;-5.42,-1.54,;-5.42,-3.08,;-6.75,-3.85,;-8.09,-3.08,;-8.09,-1.54,;-6.75,-.77,;-6.75,.77,;-8.09,1.54,;-8.09,3.08,;-6.75,3.85,;-5.42,3.08,;-5.42,1.54,;3.21,-3.26,;4.24,-2.11,;5.78,-2.11,)| Show InChI InChI=1S/C20H21FN4O2S/c21-13-1-2-16-17(9-13)28-20(25-16)24-14-10-15(11-14)27-19-18(22-5-6-23-19)12-3-7-26-8-4-12/h1-2,5-6,9,12,14-15H,3-4,7-8,10-11H2,(H,24,25)/t14-,15+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 15.1 | n/a | n/a | n/a | n/a | n/a | 25 |
Amgen Inc.
US Patent
| Assay Description
Enzyme Activity. An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 uL, of serial diluted P... |
US Patent US8952037 (2015)
BindingDB Entry DOI: 10.7270/Q23X85CW |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM144648
(US8952037, 15)Show SMILES CC(=O)N1CCC(CC1)c1nccnc1O[C@H]1C[C@@H](C1)Nc1ccc2ccccc2n1 |r,wU:18.22,wD:16.17,(-4.94,5,;-6.28,4.23,;-7.61,5,;-6.28,2.69,;-4.94,1.93,;-4.94,.38,;-6.28,-.38,;-7.61,.38,;-7.61,1.93,;-6.28,-1.93,;-7.61,-2.69,;-7.61,-4.23,;-6.28,-5,;-4.94,-4.23,;-4.94,-2.69,;-3.61,-1.93,;-2.28,-2.69,;-1.88,-4.18,;-.39,-3.78,;-.79,-2.3,;.94,-4.55,;2.28,-3.78,;2.28,-2.24,;3.61,-1.47,;4.94,-2.24,;6.28,-1.47,;7.61,-2.24,;7.61,-3.78,;6.28,-4.55,;4.94,-3.78,;3.61,-4.55,)| Show InChI InChI=1S/C24H27N5O2/c1-16(30)29-12-8-18(9-13-29)23-24(26-11-10-25-23)31-20-14-19(15-20)27-22-7-6-17-4-2-3-5-21(17)28-22/h2-7,10-11,18-20H,8-9,12-15H2,1H3,(H,27,28)/t19-,20- | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 15.8 | n/a | n/a | n/a | n/a | n/a | 25 |
Amgen Inc.
US Patent
| Assay Description
Enzyme Activity. An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 uL, of serial diluted P... |
US Patent US8952037 (2015)
BindingDB Entry DOI: 10.7270/Q23X85CW |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM144710
(US8952037, 85)Show SMILES O[C@H]1CCN(C1)c1nccnc1O[C@@H]1C[C@@H](C1)Nc1nc2ccccc2s1 |r,wD:13.14,15.19,1.0,(-4.44,4.16,;-5.21,2.83,;-6.75,2.83,;-7.23,1.36,;-5.98,.46,;-4.74,1.36,;-5.98,-1.08,;-7.32,-1.85,;-7.32,-3.39,;-5.98,-4.16,;-4.65,-3.39,;-4.65,-1.85,;-3.32,-1.08,;-1.98,-1.85,;-.5,-1.45,;-.1,-2.94,;-1.58,-3.34,;1.24,-3.71,;2.57,-2.94,;2.73,-1.41,;4.24,-1.09,;5.01,.24,;6.55,.24,;7.32,-1.09,;6.55,-2.42,;5.01,-2.42,;3.98,-3.57,)| Show InChI InChI=1S/C19H21N5O2S/c25-13-5-8-24(11-13)17-18(21-7-6-20-17)26-14-9-12(10-14)22-19-23-15-3-1-2-4-16(15)27-19/h1-4,6-7,12-14,25H,5,8-11H2,(H,22,23)/t12-,13-,14+/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 17.5 | n/a | n/a | n/a | n/a | n/a | 25 |
Amgen Inc.
US Patent
| Assay Description
Enzyme Activity. An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 uL, of serial diluted P... |
US Patent US8952037 (2015)
BindingDB Entry DOI: 10.7270/Q23X85CW |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM144693
(US8952037, 66)Show SMILES COC(=O)N1CC(C1)c1nccnc1O[C@@H]1C[C@@H](C1)Nc1nc2ccccc2s1 |r,wD:15.16,17.21,(-3.27,4.68,;-4.61,5.45,;-5.94,4.68,;-7.27,5.45,;-5.94,3.14,;-7.23,1.36,;-5.98,.46,;-4.74,1.36,;-5.98,-1.08,;-7.32,-1.85,;-7.32,-3.39,;-5.98,-4.16,;-4.65,-3.39,;-4.65,-1.85,;-3.32,-1.08,;-1.98,-1.85,;-.5,-1.45,;-.1,-2.94,;-1.58,-3.34,;1.24,-3.71,;2.57,-2.94,;2.73,-1.41,;4.24,-1.09,;5.01,.24,;6.55,.24,;7.32,-1.09,;6.55,-2.42,;5.01,-2.42,;3.98,-3.57,)| Show InChI InChI=1S/C20H21N5O3S/c1-27-20(26)25-10-12(11-25)17-18(22-7-6-21-17)28-14-8-13(9-14)23-19-24-15-4-2-3-5-16(15)29-19/h2-7,12-14H,8-11H2,1H3,(H,23,24)/t13-,14+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 17.5 | n/a | n/a | n/a | n/a | n/a | 25 |
Amgen Inc.
US Patent
| Assay Description
Enzyme Activity. An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 uL, of serial diluted P... |
US Patent US8952037 (2015)
BindingDB Entry DOI: 10.7270/Q23X85CW |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM144645
(US8952037, 12)Show SMILES Cc1ccc(N[C@H]2C[C@@H](C2)Oc2ncccc2C2CCOCC2)nc1 |r,wU:8.10,wD:6.5,(6.94,-.32,;5.61,-1.09,;4.28,-.32,;2.94,-1.09,;2.94,-2.63,;1.61,-3.4,;.28,-2.63,;-.12,-1.14,;-1.61,-1.54,;-1.21,-3.03,;-2.94,-.77,;-4.28,-1.54,;-4.28,-3.08,;-5.61,-3.85,;-6.94,-3.08,;-6.94,-1.54,;-5.61,-.77,;-5.61,.77,;-4.28,1.54,;-4.28,3.08,;-5.61,3.85,;-6.94,3.08,;-6.94,1.54,;4.28,-3.4,;5.61,-2.63,)| Show InChI InChI=1S/C20H25N3O2/c1-14-4-5-19(22-13-14)23-16-11-17(12-16)25-20-18(3-2-8-21-20)15-6-9-24-10-7-15/h2-5,8,13,15-17H,6-7,9-12H2,1H3,(H,22,23)/t16-,17- | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 17.6 | n/a | n/a | n/a | n/a | n/a | 25 |
Amgen Inc.
US Patent
| Assay Description
Enzyme Activity. An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 uL, of serial diluted P... |
US Patent US8952037 (2015)
BindingDB Entry DOI: 10.7270/Q23X85CW |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM144661
(US8952037, 34)Show SMILES Fc1ccc2sc(N[C@H]3C[C@H](C3)Oc3nccnc3C3CCOCC3)nc2c1 |r,wU:10.12,8.7,(7.32,1.89,;6.55,.56,;7.32,-.78,;6.55,-2.11,;5.01,-2.11,;3.98,-3.26,;2.57,-2.63,;1.24,-3.4,;-.1,-2.63,;-1.58,-3.03,;-1.98,-1.54,;-.5,-1.14,;-3.32,-.77,;-4.65,-1.54,;-4.65,-3.08,;-5.98,-3.85,;-7.32,-3.08,;-7.32,-1.54,;-5.98,-.77,;-5.98,.77,;-7.32,1.54,;-7.32,3.08,;-5.98,3.85,;-4.65,3.08,;-4.65,1.54,;2.73,-1.1,;4.24,-.78,;5.01,.56,)| Show InChI InChI=1S/C20H21FN4O2S/c21-13-1-2-17-16(9-13)25-20(28-17)24-14-10-15(11-14)27-19-18(22-5-6-23-19)12-3-7-26-8-4-12/h1-2,5-6,9,12,14-15H,3-4,7-8,10-11H2,(H,24,25)/t14-,15+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 18.3 | n/a | n/a | n/a | n/a | n/a | 25 |
Amgen Inc.
US Patent
| Assay Description
Enzyme Activity. An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 uL, of serial diluted P... |
US Patent US8952037 (2015)
BindingDB Entry DOI: 10.7270/Q23X85CW |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM144707
(US8952037, 82)Show SMILES O=S1(=O)CCN(CC1)c1nccnc1O[C@@H]1C[C@@H](C1)Nc1nc2ccccc2s1 |r,wD:15.16,17.21,(-6.75,4.52,;-5.98,3.18,;-5.21,4.52,;-4.65,2.41,;-4.65,.87,;-5.98,.1,;-7.32,.87,;-7.32,2.41,;-5.98,-1.44,;-7.32,-2.21,;-7.32,-3.75,;-5.98,-4.52,;-4.65,-3.75,;-4.65,-2.21,;-3.32,-1.44,;-1.98,-2.21,;-.5,-1.81,;-.1,-3.3,;-1.58,-3.69,;1.24,-4.07,;2.57,-3.3,;2.73,-1.76,;4.24,-1.44,;5.01,-.11,;6.55,-.11,;7.32,-1.44,;6.55,-2.78,;5.01,-2.78,;3.98,-3.92,)| Show InChI InChI=1S/C19H21N5O3S2/c25-29(26)9-7-24(8-10-29)17-18(21-6-5-20-17)27-14-11-13(12-14)22-19-23-15-3-1-2-4-16(15)28-19/h1-6,13-14H,7-12H2,(H,22,23)/t13-,14+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 18.5 | n/a | n/a | n/a | n/a | n/a | 25 |
Amgen Inc.
US Patent
| Assay Description
Enzyme Activity. An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 uL, of serial diluted P... |
US Patent US8952037 (2015)
BindingDB Entry DOI: 10.7270/Q23X85CW |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM144657
(US8952037, 24)Show SMILES Cc1cc(ccn1)-c1cccnc1O[C@H]1CC[C@@H](CC1)Nc1nc2ccccc2s1 |r,wU:14.15,wD:17.22,(-3.71,3.85,;-5.04,3.08,;-5.04,1.54,;-6.37,.77,;-7.71,1.54,;-7.71,3.08,;-6.37,3.85,;-6.37,-.77,;-7.71,-1.54,;-7.71,-3.08,;-6.37,-3.85,;-5.04,-3.08,;-5.04,-1.54,;-3.71,-.77,;-2.37,-1.54,;-1.04,-.77,;.29,-1.54,;.29,-3.08,;-1.04,-3.85,;-2.37,-3.08,;1.63,-3.85,;2.96,-3.08,;3.12,-1.55,;4.63,-1.23,;5.4,.11,;6.94,.11,;7.71,-1.23,;6.94,-2.56,;5.4,-2.56,;4.37,-3.71,)| Show InChI InChI=1S/C24H24N4OS/c1-16-15-17(12-14-25-16)20-5-4-13-26-23(20)29-19-10-8-18(9-11-19)27-24-28-21-6-2-3-7-22(21)30-24/h2-7,12-15,18-19H,8-11H2,1H3,(H,27,28)/t18-,19- | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 19.6 | n/a | n/a | n/a | n/a | n/a | 25 |
Amgen Inc.
US Patent
| Assay Description
Enzyme Activity. An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 uL, of serial diluted P... |
US Patent US8952037 (2015)
BindingDB Entry DOI: 10.7270/Q23X85CW |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM144678
(US8952037, 51)Show SMILES Cc1ccc(cn1)-c1nccnc1O[C@@H]1C[C@@H](C1)Nc1nc2cc(F)ccc2s1 |r,wD:14.15,16.20,(-5.98,4.62,;-5.98,3.08,;-4.65,2.31,;-4.65,.77,;-5.98,,;-7.32,.77,;-7.32,2.31,;-5.98,-1.54,;-7.32,-2.31,;-7.32,-3.85,;-5.98,-4.62,;-4.65,-3.85,;-4.65,-2.31,;-3.32,-1.54,;-1.98,-2.31,;-.5,-1.91,;-.1,-3.4,;-1.58,-3.8,;1.24,-4.17,;2.57,-3.4,;2.73,-1.87,;4.24,-1.55,;5.01,-.21,;6.55,-.21,;7.32,1.12,;7.32,-1.55,;6.55,-2.88,;5.01,-2.88,;3.98,-4.03,)| Show InChI InChI=1S/C21H18FN5OS/c1-12-2-3-13(11-25-12)19-20(24-7-6-23-19)28-16-9-15(10-16)26-21-27-17-8-14(22)4-5-18(17)29-21/h2-8,11,15-16H,9-10H2,1H3,(H,26,27)/t15-,16+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 19.7 | n/a | n/a | n/a | n/a | n/a | 25 |
Amgen Inc.
US Patent
| Assay Description
Enzyme Activity. An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 uL, of serial diluted P... |
US Patent US8952037 (2015)
BindingDB Entry DOI: 10.7270/Q23X85CW |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM144670
(US8952037, 43)Show SMILES Cc1cc(ccn1)-c1nccnc1O[C@@H]1C[C@@H](C1)Nc1nc2ccccc2s1 |r,wU:14.15,16.20,(-3.32,3.85,;-4.65,3.08,;-4.65,1.54,;-5.98,.77,;-7.32,1.54,;-7.32,3.08,;-5.98,3.85,;-5.98,-.77,;-7.32,-1.54,;-7.32,-3.08,;-5.98,-3.85,;-4.65,-3.08,;-4.65,-1.54,;-3.32,-.77,;-1.98,-1.54,;-1.58,-3.03,;-.1,-2.63,;-.5,-1.14,;1.24,-3.4,;2.57,-2.63,;2.73,-1.1,;4.24,-.78,;5.01,.56,;6.55,.56,;7.32,-.78,;6.55,-2.11,;5.01,-2.11,;3.98,-3.26,)| Show InChI InChI=1S/C21H19N5OS/c1-13-10-14(6-7-22-13)19-20(24-9-8-23-19)27-16-11-15(12-16)25-21-26-17-4-2-3-5-18(17)28-21/h2-10,15-16H,11-12H2,1H3,(H,25,26)/t15-,16+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 20.5 | n/a | n/a | n/a | n/a | n/a | 25 |
Amgen Inc.
US Patent
| Assay Description
Enzyme Activity. An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 uL, of serial diluted P... |
US Patent US8952037 (2015)
BindingDB Entry DOI: 10.7270/Q23X85CW |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM144701
(US8952037, 76)Show SMILES C1[C@@H](C[C@@H]1Oc1nccnc1N1CCOCC1)Nc1nc2ccccc2s1 |r,wD:3.4,1.19,(-.5,-1.14,;-.1,-2.63,;-1.58,-3.03,;-1.98,-1.54,;-3.32,-.77,;-4.65,-1.54,;-4.65,-3.08,;-5.98,-3.85,;-7.32,-3.08,;-7.32,-1.54,;-5.98,-.77,;-5.98,.77,;-7.32,1.54,;-7.32,3.08,;-5.98,3.85,;-4.65,3.08,;-4.65,1.54,;1.24,-3.4,;2.57,-2.63,;2.73,-1.1,;4.24,-.78,;5.01,.56,;6.55,.56,;7.32,-.78,;6.55,-2.11,;5.01,-2.11,;3.98,-3.26,)| Show InChI InChI=1S/C19H21N5O2S/c1-2-4-16-15(3-1)23-19(27-16)22-13-11-14(12-13)26-18-17(20-5-6-21-18)24-7-9-25-10-8-24/h1-6,13-14H,7-12H2,(H,22,23)/t13-,14+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 22.4 | n/a | n/a | n/a | n/a | n/a | 25 |
Amgen Inc.
US Patent
| Assay Description
Enzyme Activity. An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 uL, of serial diluted P... |
US Patent US8952037 (2015)
BindingDB Entry DOI: 10.7270/Q23X85CW |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM144720
(US8952037, 101)Show SMILES CC(=O)N1CCN(CC1)c1nccnc1O[C@@H]1C[C@@H](C1)Nc1ccc2ccccc2n1 |r,wD:16.17,18.22,(-4.94,5,;-6.28,4.23,;-7.61,5,;-6.28,2.69,;-7.61,1.92,;-7.61,.38,;-6.28,-.39,;-4.94,.38,;-4.94,1.92,;-6.28,-1.93,;-7.61,-2.7,;-7.61,-4.24,;-6.28,-5.01,;-4.94,-4.24,;-4.94,-2.7,;-3.61,-1.93,;-2.28,-2.7,;-.79,-2.3,;-.39,-3.78,;-1.88,-4.18,;.94,-4.55,;2.28,-3.78,;2.28,-2.24,;3.61,-1.47,;4.94,-2.24,;6.28,-1.47,;7.61,-2.24,;7.61,-3.78,;6.28,-4.55,;4.94,-3.78,;3.61,-4.55,)| Show InChI InChI=1S/C23H26N6O2/c1-16(30)28-10-12-29(13-11-28)22-23(25-9-8-24-22)31-19-14-18(15-19)26-21-7-6-17-4-2-3-5-20(17)27-21/h2-9,18-19H,10-15H2,1H3,(H,26,27)/t18-,19+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 23.7 | n/a | n/a | n/a | n/a | n/a | 25 |
Amgen Inc.
US Patent
| Assay Description
Enzyme Activity. An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 uL, of serial diluted P... |
US Patent US8952037 (2015)
BindingDB Entry DOI: 10.7270/Q23X85CW |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM144716
(US8952037, 91)Show SMILES OC[C@H]1CCCN(C1)c1nccnc1O[C@@H]1C[C@@H](C1)Nc1nc2ccccc2s1 |r,wD:15.16,2.1,17.21,(-1.98,8.15,;-3.32,8.92,;-4.65,8.15,;-5.98,8.92,;-7.32,8.15,;-7.32,6.61,;-5.98,5.84,;-4.65,6.61,;-5.98,4.3,;-7.32,3.53,;-7.32,1.99,;-5.98,1.22,;-4.65,1.99,;-4.65,3.53,;-3.32,4.3,;-1.98,3.53,;-.5,3.92,;-.1,2.44,;-1.58,2.04,;1.24,1.67,;2.57,2.44,;2.73,3.97,;4.24,4.29,;5.01,5.62,;6.55,5.62,;7.32,4.29,;6.55,2.96,;5.01,2.96,;3.98,1.81,)| Show InChI InChI=1S/C21H25N5O2S/c27-13-14-4-3-9-26(12-14)19-20(23-8-7-22-19)28-16-10-15(11-16)24-21-25-17-5-1-2-6-18(17)29-21/h1-2,5-8,14-16,27H,3-4,9-13H2,(H,24,25)/t14-,15-,16+/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 26 | n/a | n/a | n/a | n/a | n/a | 25 |
Amgen Inc.
US Patent
| Assay Description
Enzyme Activity. An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 uL, of serial diluted P... |
US Patent US8952037 (2015)
BindingDB Entry DOI: 10.7270/Q23X85CW |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM144736
(US8952037, 110)Show SMILES Clc1ccc(N[C@H]2C[C@H](C2)Oc2ncccc2C2CCOCC2)nc1 |r,wU:8.10,6.5,(6.94,-5.86,;5.61,-6.63,;5.61,-8.17,;4.28,-8.94,;2.94,-8.17,;1.61,-8.94,;.28,-8.17,;-1.21,-8.57,;-1.61,-7.08,;-.12,-6.68,;-2.94,-6.31,;-4.28,-7.08,;-4.28,-8.62,;-5.61,-9.39,;-6.94,-8.62,;-6.94,-7.08,;-5.61,-6.31,;-5.61,-4.77,;-4.28,-4,;-4.28,-2.46,;-5.61,-1.69,;-6.94,-2.46,;-6.94,-4,;2.94,-6.63,;4.28,-5.86,)| Show InChI InChI=1S/C19H22ClN3O2/c20-14-3-4-18(22-12-14)23-15-10-16(11-15)25-19-17(2-1-7-21-19)13-5-8-24-9-6-13/h1-4,7,12-13,15-16H,5-6,8-11H2,(H,22,23)/t15-,16+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 26.2 | n/a | n/a | n/a | n/a | n/a | 25 |
Amgen Inc.
US Patent
| Assay Description
Enzyme Activity. An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 uL, of serial diluted P... |
US Patent US8952037 (2015)
BindingDB Entry DOI: 10.7270/Q23X85CW |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM144663
(US8952037, 36)Show SMILES Fc1cccc2nc(N[C@H]3C[C@H](C3)Oc3nccnc3C3CCOCC3)sc12 |r,wU:11.13,9.8,(7.32,-3.44,;6.55,-2.11,;7.32,-.78,;6.55,.56,;5.01,.56,;4.24,-.78,;2.73,-1.1,;2.57,-2.63,;1.24,-3.4,;-.1,-2.63,;-1.58,-3.03,;-1.98,-1.54,;-.5,-1.14,;-3.32,-.77,;-4.65,-1.54,;-4.65,-3.08,;-5.98,-3.85,;-7.32,-3.08,;-7.32,-1.54,;-5.98,-.77,;-5.98,.77,;-7.32,1.54,;-7.32,3.08,;-5.98,3.85,;-4.65,3.08,;-4.65,1.54,;3.98,-3.26,;5.01,-2.11,)| Show InChI InChI=1S/C20H21FN4O2S/c21-15-2-1-3-16-18(15)28-20(25-16)24-13-10-14(11-13)27-19-17(22-6-7-23-19)12-4-8-26-9-5-12/h1-3,6-7,12-14H,4-5,8-11H2,(H,24,25)/t13-,14+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 27.1 | n/a | n/a | n/a | n/a | n/a | 25 |
Amgen Inc.
US Patent
| Assay Description
Enzyme Activity. An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 uL, of serial diluted P... |
US Patent US8952037 (2015)
BindingDB Entry DOI: 10.7270/Q23X85CW |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM144704
(US8952037, 79)Show SMILES CC1CCCN(C1)c1nccnc1O[C@@H]1C[C@@H](C1)Nc1nc2ccccc2s1 |r,wD:14.15,16.20,(-3.32,3.85,;-4.65,3.08,;-5.98,3.85,;-7.32,3.08,;-7.32,1.54,;-5.98,.77,;-4.65,1.54,;-5.98,-.77,;-7.32,-1.54,;-7.32,-3.08,;-5.98,-3.85,;-4.65,-3.08,;-4.65,-1.54,;-3.32,-.77,;-1.98,-1.54,;-.5,-1.14,;-.1,-2.63,;-1.58,-3.03,;1.24,-3.4,;2.57,-2.63,;2.73,-1.1,;4.24,-.78,;5.01,.56,;6.55,.56,;7.32,-.78,;6.55,-2.11,;5.01,-2.11,;3.98,-3.26,)| Show InChI InChI=1S/C21H25N5OS/c1-14-5-4-10-26(13-14)19-20(23-9-8-22-19)27-16-11-15(12-16)24-21-25-17-6-2-3-7-18(17)28-21/h2-3,6-9,14-16H,4-5,10-13H2,1H3,(H,24,25)/t14?,15-,16+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 29.4 | n/a | n/a | n/a | n/a | n/a | 25 |
Amgen Inc.
US Patent
| Assay Description
Enzyme Activity. An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 uL, of serial diluted P... |
US Patent US8952037 (2015)
BindingDB Entry DOI: 10.7270/Q23X85CW |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM144644
(US8952037, 11)Show SMILES C1CC(CCO1)c1cccnc1O[C@H]1CC[C@@H](CC1)Nc1nc2ccccc2s1 |r,wU:13.14,wD:16.21,(-5.04,3.08,;-5.04,1.54,;-6.37,.77,;-7.71,1.54,;-7.71,3.08,;-6.37,3.85,;-6.37,-.77,;-7.71,-1.54,;-7.71,-3.08,;-6.37,-3.85,;-5.04,-3.08,;-5.04,-1.54,;-3.71,-.77,;-2.37,-1.54,;-1.04,-.77,;.29,-1.54,;.29,-3.08,;-1.04,-3.85,;-2.37,-3.08,;1.63,-3.85,;2.96,-3.08,;3.12,-1.55,;4.63,-1.23,;5.4,.11,;6.94,.11,;7.71,-1.23,;6.94,-2.56,;5.4,-2.56,;4.37,-3.71,)| Show InChI InChI=1S/C23H27N3O2S/c1-2-6-21-20(5-1)26-23(29-21)25-17-7-9-18(10-8-17)28-22-19(4-3-13-24-22)16-11-14-27-15-12-16/h1-6,13,16-18H,7-12,14-15H2,(H,25,26)/t17-,18- | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 32.5 | n/a | n/a | n/a | n/a | n/a | 25 |
Amgen Inc.
US Patent
| Assay Description
Enzyme Activity. An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 uL, of serial diluted P... |
US Patent US8952037 (2015)
BindingDB Entry DOI: 10.7270/Q23X85CW |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM144683
(US8952037, 56)Show SMILES Cc1ccc(cc1F)-c1nccnc1O[C@H]1C[C@@H](C1)Nc1nc2ccccc2s1 |r,wU:17.21,wD:15.16,(-5.98,4.62,;-5.98,3.08,;-7.32,2.31,;-7.32,.77,;-5.98,,;-4.65,.77,;-4.65,2.31,;-3.32,3.08,;-5.98,-1.54,;-7.32,-2.31,;-7.32,-3.85,;-5.98,-4.62,;-4.65,-3.85,;-4.65,-2.31,;-3.32,-1.54,;-1.98,-2.31,;-1.58,-3.8,;-.1,-3.4,;-.5,-1.91,;1.24,-4.17,;2.57,-3.4,;2.73,-1.87,;4.24,-1.55,;5.01,-.21,;6.55,-.21,;7.32,-1.55,;6.55,-2.88,;5.01,-2.88,;3.98,-4.03,)| Show InChI InChI=1S/C22H19FN4OS/c1-13-6-7-14(10-17(13)23)20-21(25-9-8-24-20)28-16-11-15(12-16)26-22-27-18-4-2-3-5-19(18)29-22/h2-10,15-16H,11-12H2,1H3,(H,26,27)/t15-,16- | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 36.2 | n/a | n/a | n/a | n/a | n/a | 25 |
Amgen Inc.
US Patent
| Assay Description
Enzyme Activity. An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 uL, of serial diluted P... |
US Patent US8952037 (2015)
BindingDB Entry DOI: 10.7270/Q23X85CW |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM144684
(US8952037, 57)Show SMILES Cc1ccc(cc1F)-c1nccnc1O[C@H]1C[C@@H](C1)Nc1nc2ccccc2s1 |r,wU:17.21,wD:15.16,(-5.98,3.91,;-5.98,2.37,;-7.32,1.54,;-7.32,,;-5.98,-.77,;-4.65,,;-4.65,1.54,;-3.16,1.94,;-5.98,-2.31,;-7.32,-3.08,;-7.32,-4.62,;-5.98,-5.39,;-4.65,-4.62,;-4.65,-3.08,;-3.32,-2.31,;-1.98,-3.08,;-1.58,-4.57,;-.1,-4.17,;-.5,-2.68,;1.24,-4.94,;2.57,-4.17,;2.73,-2.64,;4.24,-2.32,;5.01,-.98,;6.55,-.98,;7.32,-2.32,;6.55,-3.65,;5.01,-3.65,;3.98,-4.8,)| Show InChI InChI=1S/C22H19FN4OS/c1-13-6-7-14(10-17(13)23)20-21(25-9-8-24-20)28-16-11-15(12-16)26-22-27-18-4-2-3-5-19(18)29-22/h2-10,15-16H,11-12H2,1H3,(H,26,27)/t15-,16- | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 44.4 | n/a | n/a | n/a | n/a | n/a | 25 |
Amgen Inc.
US Patent
| Assay Description
Enzyme Activity. An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 uL, of serial diluted P... |
US Patent US8952037 (2015)
BindingDB Entry DOI: 10.7270/Q23X85CW |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM144656
(US8952037, 23)Show SMILES CC(=O)N1CCC(CC1)c1nccnc1O[C@H]1CC[C@@H](CC1)Nc1nc2ccccc2s1 |r,wU:16.17,wD:19.24,(-5.04,5,;-6.37,4.23,;-7.71,5.01,;-6.37,2.69,;-5.04,1.92,;-5.04,.38,;-6.37,-.39,;-7.71,.38,;-7.71,1.92,;-6.37,-1.93,;-7.71,-2.7,;-7.71,-4.24,;-6.37,-5.01,;-5.04,-4.24,;-5.04,-2.7,;-3.71,-1.93,;-2.37,-2.7,;-1.04,-1.92,;.29,-2.7,;.29,-4.24,;-1.04,-5.01,;-2.37,-4.24,;1.63,-5.01,;2.96,-4.24,;3.12,-2.7,;4.63,-2.38,;5.4,-1.05,;6.94,-1.05,;7.71,-2.38,;6.94,-3.72,;5.4,-3.72,;4.37,-4.86,)| Show InChI InChI=1S/C24H29N5O2S/c1-16(30)29-14-10-17(11-15-29)22-23(26-13-12-25-22)31-19-8-6-18(7-9-19)27-24-28-20-4-2-3-5-21(20)32-24/h2-5,12-13,17-19H,6-11,14-15H2,1H3,(H,27,28)/t18-,19- | PDB
MMDB
Reactome pathway
KEGG
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antibodypedia
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| PC cid
PC sid
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Similars
| US Patent
| n/a | n/a | 45.5 | n/a | n/a | n/a | n/a | n/a | 25 |
Amgen Inc.
US Patent
| Assay Description
Enzyme Activity. An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 uL, of serial diluted P... |
US Patent US8952037 (2015)
BindingDB Entry DOI: 10.7270/Q23X85CW |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM144640
(US8952037, 7)Show SMILES Cc1cccnc1N[C@H]1CC[C@@H](CC1)Oc1ncccc1C1CCOCC1 |r,wU:8.8,wD:11.15,(2.67,-.77,;4,-1.54,;5.33,-.77,;6.67,-1.54,;6.67,-3.08,;5.33,-3.85,;4,-3.08,;2.67,-3.85,;1.33,-3.08,;,-3.85,;-1.33,-3.08,;-1.33,-1.54,;,-.77,;1.33,-1.54,;-2.67,-.77,;-4,-1.54,;-4,-3.08,;-5.33,-3.85,;-6.67,-3.08,;-6.67,-1.54,;-5.33,-.77,;-5.33,.77,;-4,1.54,;-4,3.08,;-5.33,3.85,;-6.67,3.08,;-6.67,1.54,)| Show InChI InChI=1S/C22H29N3O2/c1-16-4-2-12-23-21(16)25-18-6-8-19(9-7-18)27-22-20(5-3-13-24-22)17-10-14-26-15-11-17/h2-5,12-13,17-19H,6-11,14-15H2,1H3,(H,23,25)/t18-,19- | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 46 | n/a | n/a | n/a | n/a | n/a | 25 |
Amgen Inc.
US Patent
| Assay Description
Enzyme Activity. An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 uL, of serial diluted P... |
US Patent US8952037 (2015)
BindingDB Entry DOI: 10.7270/Q23X85CW |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM144652
(US8952037, 19)Show SMILES CC(=O)N1CCC(CC1)c1nccnc1O[C@@H]1C[C@@H](C1)Nc1ccc(C)cn1 |r,wU:16.17,18.22,(-4.28,5,;-5.61,4.23,;-6.94,5.01,;-5.61,2.69,;-4.28,1.92,;-4.28,.38,;-5.61,-.39,;-6.94,.38,;-6.94,1.92,;-5.61,-1.93,;-6.94,-2.7,;-6.94,-4.24,;-5.61,-5.01,;-4.28,-4.24,;-4.28,-2.7,;-2.94,-1.93,;-1.61,-2.7,;-1.21,-4.18,;.28,-3.78,;-.12,-2.3,;1.61,-4.55,;2.94,-3.78,;2.94,-2.24,;4.28,-1.47,;5.61,-2.24,;6.94,-1.47,;5.61,-3.78,;4.28,-4.55,)| Show InChI InChI=1S/C21H27N5O2/c1-14-3-4-19(24-13-14)25-17-11-18(12-17)28-21-20(22-7-8-23-21)16-5-9-26(10-6-16)15(2)27/h3-4,7-8,13,16-18H,5-6,9-12H2,1-2H3,(H,24,25)/t17-,18+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 66.1 | n/a | n/a | n/a | n/a | n/a | 25 |
Amgen Inc.
US Patent
| Assay Description
Enzyme Activity. An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 uL, of serial diluted P... |
US Patent US8952037 (2015)
BindingDB Entry DOI: 10.7270/Q23X85CW |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM144736
(US8952037, 110)Show SMILES Clc1ccc(N[C@H]2C[C@H](C2)Oc2ncccc2C2CCOCC2)nc1 |r,wU:8.10,6.5,(6.94,-5.86,;5.61,-6.63,;5.61,-8.17,;4.28,-8.94,;2.94,-8.17,;1.61,-8.94,;.28,-8.17,;-1.21,-8.57,;-1.61,-7.08,;-.12,-6.68,;-2.94,-6.31,;-4.28,-7.08,;-4.28,-8.62,;-5.61,-9.39,;-6.94,-8.62,;-6.94,-7.08,;-5.61,-6.31,;-5.61,-4.77,;-4.28,-4,;-4.28,-2.46,;-5.61,-1.69,;-6.94,-2.46,;-6.94,-4,;2.94,-6.63,;4.28,-5.86,)| Show InChI InChI=1S/C19H22ClN3O2/c20-14-3-4-18(22-12-14)23-15-10-16(11-15)25-19-17(2-1-7-21-19)13-5-8-24-9-6-13/h1-4,7,12-13,15-16H,5-6,8-11H2,(H,22,23)/t15-,16+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
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AffyNet
| PC cid
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UniChem
Similars
| US Patent
| n/a | n/a | 83.7 | n/a | n/a | n/a | n/a | n/a | 25 |
Amgen Inc.
US Patent
| Assay Description
Enzyme Activity. An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 uL, of serial diluted P... |
US Patent US8952037 (2015)
BindingDB Entry DOI: 10.7270/Q23X85CW |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM144653
(US8952037, 20)Show SMILES CC(=O)N1CCC(CC1)c1nccnc1O[C@H]1C[C@@H](C1)Nc1ccc(C)cn1 |r,wU:16.17,wD:18.22,(-4.28,5,;-5.61,4.23,;-6.94,5.01,;-5.61,2.69,;-4.28,1.92,;-4.28,.38,;-5.61,-.39,;-6.94,.38,;-6.94,1.92,;-5.61,-1.93,;-6.94,-2.7,;-6.94,-4.24,;-5.61,-5.01,;-4.28,-4.24,;-4.28,-2.7,;-2.94,-1.93,;-1.61,-2.7,;-.12,-2.3,;.28,-3.78,;-1.21,-4.18,;1.61,-4.55,;2.94,-3.78,;2.94,-2.24,;4.28,-1.47,;5.61,-2.24,;6.94,-1.47,;5.61,-3.78,;4.28,-4.55,)| Show InChI InChI=1S/C21H27N5O2/c1-14-3-4-19(24-13-14)25-17-11-18(12-17)28-21-20(22-7-8-23-21)16-5-9-26(10-6-16)15(2)27/h3-4,7-8,13,16-18H,5-6,9-12H2,1-2H3,(H,24,25)/t17-,18- | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 84.5 | n/a | n/a | n/a | n/a | n/a | 25 |
Amgen Inc.
US Patent
| Assay Description
Enzyme Activity. An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 uL, of serial diluted P... |
US Patent US8952037 (2015)
BindingDB Entry DOI: 10.7270/Q23X85CW |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM144642
(US8952037, 9)Show SMILES C1CC(CCO1)c1cccnc1O[C@H]1CC[C@@H](CC1)Nc1ccc2ccccc2n1 |r,wU:16.21,wD:13.14,(-5.33,3.08,;-5.33,1.54,;-6.67,.77,;-8,1.54,;-8,3.08,;-6.67,3.85,;-6.67,-.77,;-8,-1.54,;-8,-3.08,;-6.67,-3.85,;-5.33,-3.08,;-5.33,-1.54,;-4,-.77,;-2.67,-1.54,;-2.67,-3.08,;-1.33,-3.85,;,-3.08,;,-1.54,;-1.33,-.77,;1.33,-3.85,;2.67,-3.08,;2.67,-1.54,;4,-.77,;5.33,-1.54,;6.67,-.77,;8,-1.54,;8,-3.08,;6.67,-3.85,;5.33,-3.08,;4,-3.85,)| Show InChI InChI=1S/C25H29N3O2/c1-2-6-23-19(4-1)7-12-24(28-23)27-20-8-10-21(11-9-20)30-25-22(5-3-15-26-25)18-13-16-29-17-14-18/h1-7,12,15,18,20-21H,8-11,13-14,16-17H2,(H,27,28)/t20-,21- | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 91 | n/a | n/a | n/a | n/a | n/a | 25 |
Amgen Inc.
US Patent
| Assay Description
Enzyme Activity. An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 uL, of serial diluted P... |
US Patent US8952037 (2015)
BindingDB Entry DOI: 10.7270/Q23X85CW |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM144724
(US8952037, 108)Show SMILES FC(F)(F)c1ccc(N[C@H]2C[C@@H](C2)Oc2ncccc2C2CCOCC2)nc1 |r,wU:11.13,wD:9.8,(7.66,6.06,;6.33,5.29,;7.1,3.95,;5.56,6.62,;4.99,4.52,;4.94,2.95,;3.61,2.18,;2.28,2.95,;.94,2.18,;-.39,2.95,;-.79,4.44,;-2.28,4.04,;-1.88,2.55,;-3.61,4.81,;-4.94,4.04,;-4.94,2.5,;-6.28,1.73,;-7.61,2.5,;-7.61,4.04,;-6.28,4.81,;-6.28,6.35,;-4.94,7.12,;-4.94,8.66,;-6.28,9.43,;-7.61,8.66,;-7.61,7.12,;2.28,4.49,;3.61,5.26,)| Show InChI InChI=1S/C20H22F3N3O2/c21-20(22,23)14-3-4-18(25-12-14)26-15-10-16(11-15)28-19-17(2-1-7-24-19)13-5-8-27-9-6-13/h1-4,7,12-13,15-16H,5-6,8-11H2,(H,25,26)/t15-,16- | PDB
MMDB
Reactome pathway
KEGG
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B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 106 | n/a | n/a | n/a | n/a | n/a | 25 |
Amgen Inc.
US Patent
| Assay Description
Enzyme Activity. An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 uL, of serial diluted P... |
US Patent US8952037 (2015)
BindingDB Entry DOI: 10.7270/Q23X85CW |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM144712
(US8952037, 87)Show SMILES CN1CCN(CC1)c1nccnc1O[C@@H]1C[C@@H](C1)Nc1nc2ccccc2s1 |r,wU:14.15,16.20,(-5.78,5.19,;-5.78,3.65,;-4.45,2.88,;-4.45,1.34,;-5.78,.57,;-7.12,1.34,;-7.12,2.88,;-5.78,-.97,;-7.12,-1.74,;-7.12,-3.28,;-5.78,-4.05,;-4.45,-3.28,;-4.45,-1.74,;-3.12,-.97,;-2.03,-2.06,;-2.03,-3.6,;-.49,-3.6,;-.49,-2.06,;.6,-4.69,;2.09,-4.29,;2.56,-2.82,;4.1,-2.82,;5.14,-1.68,;6.64,-2,;7.12,-3.46,;6.09,-4.61,;4.58,-4.29,;3.33,-5.19,)| Show InChI InChI=1S/C20H24N6OS/c1-25-8-10-26(11-9-25)18-19(22-7-6-21-18)27-15-12-14(13-15)23-20-24-16-4-2-3-5-17(16)28-20/h2-7,14-15H,8-13H2,1H3,(H,23,24)/t14-,15+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 122 | n/a | n/a | n/a | n/a | n/a | 25 |
Amgen Inc.
US Patent
| Assay Description
Enzyme Activity. An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 uL, of serial diluted P... |
US Patent US8952037 (2015)
BindingDB Entry DOI: 10.7270/Q23X85CW |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM144639
(US8952037, 6)Show SMILES Cc1ccnc(N[C@H]2CC[C@@H](CC2)Oc2ncccc2C2CCOCC2)c1 |r,wU:7.6,wD:10.13,(5.33,.77,;5.33,-.77,;6.67,-1.54,;6.67,-3.08,;5.33,-3.85,;4,-3.08,;2.67,-3.85,;1.33,-3.08,;,-3.85,;-1.33,-3.08,;-1.33,-1.54,;,-.77,;1.33,-1.54,;-2.67,-.77,;-4,-1.54,;-4,-3.08,;-5.33,-3.85,;-6.67,-3.08,;-6.67,-1.54,;-5.33,-.77,;-5.33,.77,;-4,1.54,;-4,3.08,;-5.33,3.85,;-6.67,3.08,;-6.67,1.54,;4,-1.54,)| Show InChI InChI=1S/C22H29N3O2/c1-16-8-12-23-21(15-16)25-18-4-6-19(7-5-18)27-22-20(3-2-11-24-22)17-9-13-26-14-10-17/h2-3,8,11-12,15,17-19H,4-7,9-10,13-14H2,1H3,(H,23,25)/t18-,19- | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 150 | n/a | n/a | n/a | n/a | n/a | 25 |
Amgen Inc.
US Patent
| Assay Description
Enzyme Activity. An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 uL, of serial diluted P... |
US Patent US8952037 (2015)
BindingDB Entry DOI: 10.7270/Q23X85CW |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM144651
(US8952037, 18)Show SMILES O=C(C1CC(C1)Oc1ncccc1C1CCOCC1)c1ccccn1 |(2.28,-4.39,;2.28,-2.85,;.94,-2.08,;-.54,-2.48,;-.94,-1,;.54,-.6,;-2.28,-.23,;-3.61,-1,;-3.61,-2.54,;-4.94,-3.31,;-6.28,-2.54,;-6.28,-1,;-4.94,-.23,;-4.94,1.31,;-3.61,2.08,;-3.61,3.62,;-4.94,4.39,;-6.28,3.62,;-6.28,2.08,;3.61,-2.08,;3.61,-.54,;4.94,.23,;6.28,-.54,;6.28,-2.08,;4.94,-2.85,)| Show InChI InChI=1S/C20H22N2O3/c23-19(18-5-1-2-8-21-18)15-12-16(13-15)25-20-17(4-3-9-22-20)14-6-10-24-11-7-14/h1-5,8-9,14-16H,6-7,10-13H2 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 250 | n/a | n/a | n/a | n/a | n/a | 25 |
Amgen Inc.
US Patent
| Assay Description
Enzyme Activity. An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 uL, of serial diluted P... |
US Patent US8952037 (2015)
BindingDB Entry DOI: 10.7270/Q23X85CW |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM144714
(US8952037, 89)Show SMILES CN1CCN(CC1)c1nccnc1O[C@@H]1C[C@@H](C1)Nc1ncc2ccccc2n1 |r,wD:14.15,16.20,(-6.28,4.62,;-6.28,3.08,;-4.94,2.31,;-4.94,.77,;-6.28,,;-7.61,.77,;-7.61,2.31,;-6.28,-1.54,;-7.61,-2.31,;-7.61,-3.85,;-6.28,-4.62,;-4.94,-3.85,;-4.94,-2.31,;-3.61,-1.54,;-2.28,-2.31,;-.79,-1.91,;-.39,-3.4,;-1.88,-3.8,;.94,-4.17,;2.28,-3.4,;2.28,-1.86,;3.61,-1.09,;4.94,-1.86,;6.28,-1.09,;7.61,-1.86,;7.61,-3.4,;6.28,-4.17,;4.94,-3.4,;3.61,-4.17,)| Show InChI InChI=1S/C21H25N7O/c1-27-8-10-28(11-9-27)19-20(23-7-6-22-19)29-17-12-16(13-17)25-21-24-14-15-4-2-3-5-18(15)26-21/h2-7,14,16-17H,8-13H2,1H3,(H,24,25,26)/t16-,17+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 316 | n/a | n/a | n/a | n/a | n/a | 25 |
Amgen Inc.
US Patent
| Assay Description
Enzyme Activity. An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 uL, of serial diluted P... |
US Patent US8952037 (2015)
BindingDB Entry DOI: 10.7270/Q23X85CW |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM144724
(US8952037, 108)Show SMILES FC(F)(F)c1ccc(N[C@H]2C[C@@H](C2)Oc2ncccc2C2CCOCC2)nc1 |r,wU:11.13,wD:9.8,(7.66,6.06,;6.33,5.29,;7.1,3.95,;5.56,6.62,;4.99,4.52,;4.94,2.95,;3.61,2.18,;2.28,2.95,;.94,2.18,;-.39,2.95,;-.79,4.44,;-2.28,4.04,;-1.88,2.55,;-3.61,4.81,;-4.94,4.04,;-4.94,2.5,;-6.28,1.73,;-7.61,2.5,;-7.61,4.04,;-6.28,4.81,;-6.28,6.35,;-4.94,7.12,;-4.94,8.66,;-6.28,9.43,;-7.61,8.66,;-7.61,7.12,;2.28,4.49,;3.61,5.26,)| Show InChI InChI=1S/C20H22F3N3O2/c21-20(22,23)14-3-4-18(25-12-14)26-15-10-16(11-15)28-19-17(2-1-7-24-19)13-5-8-27-9-6-13/h1-4,7,12-13,15-16H,5-6,8-11H2,(H,25,26)/t15-,16- | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
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| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 436 | n/a | n/a | n/a | n/a | n/a | 25 |
Amgen Inc.
US Patent
| Assay Description
Enzyme Activity. An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 uL, of serial diluted P... |
US Patent US8952037 (2015)
BindingDB Entry DOI: 10.7270/Q23X85CW |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM144723
(US8952037, 106)Show SMILES N#Cc1ccc(N[C@H]2C[C@H](C2)Oc2ncccc2C2CCOCC2)nc1 |r,wD:9.11,7.6,(7.66,6.06,;6.33,5.29,;4.99,4.52,;4.94,2.95,;3.61,2.18,;2.28,2.95,;.94,2.18,;-.39,2.95,;-.79,4.44,;-2.28,4.04,;-1.88,2.55,;-3.61,4.81,;-4.94,4.04,;-4.94,2.5,;-6.28,1.73,;-7.61,2.5,;-7.61,4.04,;-6.28,4.81,;-6.28,6.35,;-4.94,7.12,;-4.94,8.66,;-6.28,9.43,;-7.61,8.66,;-7.61,7.12,;2.28,4.49,;3.61,5.26,)| Show InChI InChI=1S/C20H22N4O2/c21-12-14-3-4-19(23-13-14)24-16-10-17(11-16)26-20-18(2-1-7-22-20)15-5-8-25-9-6-15/h1-4,7,13,15-17H,5-6,8-11H2,(H,23,24)/t16-,17+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 590 | n/a | n/a | n/a | n/a | n/a | 25 |
Amgen Inc.
US Patent
| Assay Description
Enzyme Activity. An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 uL, of serial diluted P... |
US Patent US8952037 (2015)
BindingDB Entry DOI: 10.7270/Q23X85CW |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM144735
(US8952037, 109)Show SMILES FC(F)(F)c1ccc(N[C@H]2C[C@H](C2)Oc2ncccc2C2CCOCC2)nc1 |r,wD:11.13,9.8,(7.66,6.06,;6.33,5.29,;7.1,3.95,;5.56,6.62,;4.99,4.52,;4.94,2.95,;3.61,2.18,;2.28,2.95,;.94,2.18,;-.39,2.95,;-.79,4.44,;-2.28,4.04,;-1.88,2.55,;-3.61,4.81,;-4.94,4.04,;-4.94,2.5,;-6.28,1.73,;-7.61,2.5,;-7.61,4.04,;-6.28,4.81,;-6.28,6.35,;-4.94,7.12,;-4.94,8.66,;-6.28,9.43,;-7.61,8.66,;-7.61,7.12,;2.28,4.49,;3.61,5.26,)| Show InChI InChI=1S/C20H22F3N3O2/c21-20(22,23)14-3-4-18(25-12-14)26-15-10-16(11-15)28-19-17(2-1-7-24-19)13-5-8-27-9-6-13/h1-4,7,12-13,15-16H,5-6,8-11H2,(H,25,26)/t15-,16+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 590 | n/a | n/a | n/a | n/a | n/a | 25 |
Amgen Inc.
US Patent
| Assay Description
Enzyme Activity. An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 uL, of serial diluted P... |
US Patent US8952037 (2015)
BindingDB Entry DOI: 10.7270/Q23X85CW |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM144725
(US8952037, 111)Show SMILES Clc1ccc(N[C@H]2C[C@@H](C2)Oc2ncccc2C2CCOCC2)nc1 |r,wU:8.10,wD:6.5,(6.94,-5.86,;5.61,-6.63,;5.61,-8.17,;4.28,-8.94,;2.94,-8.17,;1.61,-8.94,;.28,-8.17,;-.12,-6.68,;-1.61,-7.08,;-1.21,-8.57,;-2.94,-6.31,;-4.28,-7.08,;-4.28,-8.62,;-5.61,-9.39,;-6.94,-8.62,;-6.94,-7.08,;-5.61,-6.31,;-5.61,-4.77,;-4.28,-4,;-4.28,-2.46,;-5.61,-1.69,;-6.94,-2.46,;-6.94,-4,;2.94,-6.63,;4.28,-5.86,)| Show InChI InChI=1S/C19H22ClN3O2/c20-14-3-4-18(22-12-14)23-15-10-16(11-15)25-19-17(2-1-7-21-19)13-5-8-24-9-6-13/h1-4,7,12-13,15-16H,5-6,8-11H2,(H,22,23)/t15-,16- | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 590 | n/a | n/a | n/a | n/a | n/a | 25 |
Amgen Inc.
US Patent
| Assay Description
Enzyme Activity. An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 uL, of serial diluted P... |
US Patent US8952037 (2015)
BindingDB Entry DOI: 10.7270/Q23X85CW |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM144735
(US8952037, 109)Show SMILES FC(F)(F)c1ccc(N[C@H]2C[C@H](C2)Oc2ncccc2C2CCOCC2)nc1 |r,wD:11.13,9.8,(7.66,6.06,;6.33,5.29,;7.1,3.95,;5.56,6.62,;4.99,4.52,;4.94,2.95,;3.61,2.18,;2.28,2.95,;.94,2.18,;-.39,2.95,;-.79,4.44,;-2.28,4.04,;-1.88,2.55,;-3.61,4.81,;-4.94,4.04,;-4.94,2.5,;-6.28,1.73,;-7.61,2.5,;-7.61,4.04,;-6.28,4.81,;-6.28,6.35,;-4.94,7.12,;-4.94,8.66,;-6.28,9.43,;-7.61,8.66,;-7.61,7.12,;2.28,4.49,;3.61,5.26,)| Show InChI InChI=1S/C20H22F3N3O2/c21-20(22,23)14-3-4-18(25-12-14)26-15-10-16(11-15)28-19-17(2-1-7-24-19)13-5-8-27-9-6-13/h1-4,7,12-13,15-16H,5-6,8-11H2,(H,25,26)/t15-,16+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 865 | n/a | n/a | n/a | n/a | n/a | 25 |
Amgen Inc.
US Patent
| Assay Description
Enzyme Activity. An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 uL, of serial diluted P... |
US Patent US8952037 (2015)
BindingDB Entry DOI: 10.7270/Q23X85CW |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM144725
(US8952037, 111)Show SMILES Clc1ccc(N[C@H]2C[C@@H](C2)Oc2ncccc2C2CCOCC2)nc1 |r,wU:8.10,wD:6.5,(6.94,-5.86,;5.61,-6.63,;5.61,-8.17,;4.28,-8.94,;2.94,-8.17,;1.61,-8.94,;.28,-8.17,;-.12,-6.68,;-1.61,-7.08,;-1.21,-8.57,;-2.94,-6.31,;-4.28,-7.08,;-4.28,-8.62,;-5.61,-9.39,;-6.94,-8.62,;-6.94,-7.08,;-5.61,-6.31,;-5.61,-4.77,;-4.28,-4,;-4.28,-2.46,;-5.61,-1.69,;-6.94,-2.46,;-6.94,-4,;2.94,-6.63,;4.28,-5.86,)| Show InChI InChI=1S/C19H22ClN3O2/c20-14-3-4-18(22-12-14)23-15-10-16(11-15)25-19-17(2-1-7-21-19)13-5-8-24-9-6-13/h1-4,7,12-13,15-16H,5-6,8-11H2,(H,22,23)/t15-,16- | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 865 | n/a | n/a | n/a | n/a | n/a | 25 |
Amgen Inc.
US Patent
| Assay Description
Enzyme Activity. An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 uL, of serial diluted P... |
US Patent US8952037 (2015)
BindingDB Entry DOI: 10.7270/Q23X85CW |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM144734
(US8952037, 107)Show SMILES N#Cc1ccc(N[C@H]2C[C@@H](C2)Oc2ncccc2C2CCOCC2)nc1 |r,wU:9.11,wD:7.6,(7.66,6.06,;6.33,5.29,;4.99,4.52,;4.94,2.95,;3.61,2.18,;2.28,2.95,;.94,2.18,;-.39,2.95,;-.79,4.44,;-2.28,4.04,;-1.88,2.55,;-3.61,4.81,;-4.94,4.04,;-4.94,2.5,;-6.28,1.73,;-7.61,2.5,;-7.61,4.04,;-6.28,4.81,;-6.28,6.35,;-4.94,7.12,;-4.94,8.66,;-6.28,9.43,;-7.61,8.66,;-7.61,7.12,;2.28,4.49,;3.61,5.26,)| Show InChI InChI=1S/C20H22N4O2/c21-12-14-3-4-19(23-13-14)24-16-10-17(11-16)26-20-18(2-1-7-22-20)15-5-8-25-9-6-15/h1-4,7,13,15-17H,5-6,8-11H2,(H,23,24)/t16-,17- | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 865 | n/a | n/a | n/a | n/a | n/a | 25 |
Amgen Inc.
US Patent
| Assay Description
Enzyme Activity. An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 uL, of serial diluted P... |
US Patent US8952037 (2015)
BindingDB Entry DOI: 10.7270/Q23X85CW |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM144641
(US8952037, 8)Show SMILES Cc1cccc(N[C@H]2CC[C@@H](CC2)Oc2ncccc2C2CCOCC2)n1 |r,wU:7.6,wD:10.13,(7.34,-3.85,;6,-3.08,;6,-1.54,;4.67,-.77,;3.33,-1.54,;3.33,-3.08,;2,-3.85,;.67,-3.08,;-.67,-3.85,;-2,-3.08,;-2,-1.54,;-.67,-.77,;.67,-1.54,;-3.33,-.77,;-4.67,-1.54,;-4.67,-3.08,;-6,-3.85,;-7.34,-3.08,;-7.34,-1.54,;-6,-.77,;-6,.77,;-4.67,1.54,;-4.67,3.08,;-6,3.85,;-7.34,3.08,;-7.34,1.54,;4.67,-3.85,)| Show InChI InChI=1S/C22H29N3O2/c1-16-4-2-6-21(24-16)25-18-7-9-19(10-8-18)27-22-20(5-3-13-23-22)17-11-14-26-15-12-17/h2-6,13,17-19H,7-12,14-15H2,1H3,(H,24,25)/t18-,19- | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 1.75E+3 | n/a | n/a | n/a | n/a | n/a | 25 |
Amgen Inc.
US Patent
| Assay Description
Enzyme Activity. An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 uL, of serial diluted P... |
US Patent US8952037 (2015)
BindingDB Entry DOI: 10.7270/Q23X85CW |
More data for this
Ligand-Target Pair | |
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