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USPatent US8975267

Compile data set for download or QSAR
Found 51 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))		BDBM149692
PNG
(US8975267, 34)
Show SMILES CSc1ncc2ccc3c(cn([C@@H]4CC[C@H](N)CC4)c3c2n1)C(N)=O |wU:15.15,12.11,(6.59,1.87,;5.05,1.92,;4.24,.61,;4.97,-.75,;4.16,-2.06,;2.62,-2.01,;1.81,-3.32,;.27,-3.27,;-.46,-1.92,;-1.96,-1.55,;-2.07,-.01,;-.64,.57,;-.28,2.07,;1.2,2.49,;1.57,3.99,;.46,5.06,;.82,6.55,;-1.02,4.63,;-1.39,3.13,;.35,-.61,;1.89,-.65,;2.7,.65,;-3.13,-2.54,;-2.86,-4.06,;-4.58,-2.02,)|
Show InChI InChI=1S/C18H21N5OS/c1-25-18-21-8-10-2-7-13-14(17(20)24)9-23(16(13)15(10)22-18)12-5-3-11(19)4-6-12/h2,7-9,11-12H,3-6,19H2,1H3,(H2,20,24)/t11-,12+
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n/an/a 0.800n/an/an/an/a3.0n/a



Nerviano Medical Sciences S.r.l.

US Patent


Assay Description
Specific peptide or protein substrates are trans-phosphorylated by their specific ser-thr or tyr kinase in the presence of ATP traced with 33P-gamma-...

US Patent US8975267 (2015)


BindingDB Entry DOI: 10.7270/Q29C6W41
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))		BDBM149692
PNG
(US8975267, 34)
Show SMILES CSc1ncc2ccc3c(cn([C@@H]4CC[C@H](N)CC4)c3c2n1)C(N)=O |wU:15.15,12.11,(6.59,1.87,;5.05,1.92,;4.24,.61,;4.97,-.75,;4.16,-2.06,;2.62,-2.01,;1.81,-3.32,;.27,-3.27,;-.46,-1.92,;-1.96,-1.55,;-2.07,-.01,;-.64,.57,;-.28,2.07,;1.2,2.49,;1.57,3.99,;.46,5.06,;.82,6.55,;-1.02,4.63,;-1.39,3.13,;.35,-.61,;1.89,-.65,;2.7,.65,;-3.13,-2.54,;-2.86,-4.06,;-4.58,-2.02,)|
Show InChI InChI=1S/C18H21N5OS/c1-25-18-21-8-10-2-7-13-14(17(20)24)9-23(16(13)15(10)22-18)12-5-3-11(19)4-6-12/h2,7-9,11-12H,3-6,19H2,1H3,(H2,20,24)/t11-,12+
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n/an/a 1n/an/an/an/a7.5n/a



Nerviano Medical Sciences S.r.l.

US Patent


Assay Description
The buffer for PIM-2 assay was composed of HEPES 50 mM, at pH 7.5, with 1 mM MgCl2, 1 mM DTT, 3 microM Na3VO4, and 0.2 mg/mL BSAFull-length human PIM...

US Patent US8975267 (2015)


BindingDB Entry DOI: 10.7270/Q29C6W41
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))		BDBM149689
PNG
(US8975267, 30)
Show SMILES CSc1ncc2ccc3c(C(N)=O)c(C)n(C(C)C)c3c2n1
Show InChI InChI=1S/C16H18N4OS/c1-8(2)20-9(3)12(15(17)21)11-6-5-10-7-18-16(22-4)19-13(10)14(11)20/h5-8H,1-4H3,(H2,17,21)
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n/an/a 4n/an/an/an/a3.0n/a



Nerviano Medical Sciences S.r.l.

US Patent


Assay Description
Specific peptide or protein substrates are trans-phosphorylated by their specific ser-thr or tyr kinase in the presence of ATP traced with 33P-gamma-...

US Patent US8975267 (2015)


BindingDB Entry DOI: 10.7270/Q29C6W41
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))		BDBM149691
PNG
(US8975267, 33)
Show SMILES CSc1ncc2CCc3c(cn([C@@H]4CC[C@H](N)CC4)c3-c2n1)C(N)=O |wU:15.15,12.11,(6.59,1.87,;5.05,1.92,;4.24,.61,;4.97,-.75,;4.16,-2.06,;2.62,-2.01,;1.81,-3.32,;.27,-3.27,;-.46,-1.92,;-1.96,-1.55,;-2.07,-.01,;-.64,.57,;-.28,2.07,;1.2,2.49,;1.57,3.99,;.46,5.06,;.82,6.55,;-1.02,4.63,;-1.39,3.13,;.35,-.61,;1.89,-.65,;2.7,.65,;-3.13,-2.54,;-2.86,-4.06,;-4.58,-2.02,)|
Show InChI InChI=1S/C18H23N5OS/c1-25-18-21-8-10-2-7-13-14(17(20)24)9-23(16(13)15(10)22-18)12-5-3-11(19)4-6-12/h8-9,11-12H,2-7,19H2,1H3,(H2,20,24)/t11-,12+
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n/an/a 5n/an/an/an/a3.0n/a



Nerviano Medical Sciences S.r.l.

US Patent


Assay Description
Specific peptide or protein substrates are trans-phosphorylated by their specific ser-thr or tyr kinase in the presence of ATP traced with 33P-gamma-...

US Patent US8975267 (2015)


BindingDB Entry DOI: 10.7270/Q29C6W41
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))		BDBM149691
PNG
(US8975267, 33)
Show SMILES CSc1ncc2CCc3c(cn([C@@H]4CC[C@H](N)CC4)c3-c2n1)C(N)=O |wU:15.15,12.11,(6.59,1.87,;5.05,1.92,;4.24,.61,;4.97,-.75,;4.16,-2.06,;2.62,-2.01,;1.81,-3.32,;.27,-3.27,;-.46,-1.92,;-1.96,-1.55,;-2.07,-.01,;-.64,.57,;-.28,2.07,;1.2,2.49,;1.57,3.99,;.46,5.06,;.82,6.55,;-1.02,4.63,;-1.39,3.13,;.35,-.61,;1.89,-.65,;2.7,.65,;-3.13,-2.54,;-2.86,-4.06,;-4.58,-2.02,)|
Show InChI InChI=1S/C18H23N5OS/c1-25-18-21-8-10-2-7-13-14(17(20)24)9-23(16(13)15(10)22-18)12-5-3-11(19)4-6-12/h8-9,11-12H,2-7,19H2,1H3,(H2,20,24)/t11-,12+
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n/an/a 7n/an/an/an/a7.5n/a



Nerviano Medical Sciences S.r.l.

US Patent


Assay Description
The buffer for PIM-2 assay was composed of HEPES 50 mM, at pH 7.5, with 1 mM MgCl2, 1 mM DTT, 3 microM Na3VO4, and 0.2 mg/mL BSAFull-length human PIM...

US Patent US8975267 (2015)


BindingDB Entry DOI: 10.7270/Q29C6W41
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))		BDBM149693
PNG
(US8975267, 35)
Show SMILES CSc1ncc2ccc3c(cn(C4CCNCC4)c3c2n1)C(N)=O
Show InChI InChI=1S/C17H19N5OS/c1-24-17-20-8-10-2-3-12-13(16(18)23)9-22(15(12)14(10)21-17)11-4-6-19-7-5-11/h2-3,8-9,11,19H,4-7H2,1H3,(H2,18,23)
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n/an/a 7n/an/an/an/a3.0n/a



Nerviano Medical Sciences S.r.l.

US Patent


Assay Description
Specific peptide or protein substrates are trans-phosphorylated by their specific ser-thr or tyr kinase in the presence of ATP traced with 33P-gamma-...

US Patent US8975267 (2015)


BindingDB Entry DOI: 10.7270/Q29C6W41
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))		BDBM149689
PNG
(US8975267, 30)
Show SMILES CSc1ncc2ccc3c(C(N)=O)c(C)n(C(C)C)c3c2n1
Show InChI InChI=1S/C16H18N4OS/c1-8(2)20-9(3)12(15(17)21)11-6-5-10-7-18-16(22-4)19-13(10)14(11)20/h5-8H,1-4H3,(H2,17,21)
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n/an/a 12n/an/an/an/a7.5n/a



Nerviano Medical Sciences S.r.l.

US Patent


Assay Description
The buffer for PIM-2 assay was composed of HEPES 50 mM, at pH 7.5, with 1 mM MgCl2, 1 mM DTT, 3 microM Na3VO4, and 0.2 mg/mL BSAFull-length human PIM...

US Patent US8975267 (2015)


BindingDB Entry DOI: 10.7270/Q29C6W41
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))		BDBM149694
PNG
(US8975267, 36)
Show SMILES CSc1ncc2ccc3c(c[nH]c3c2n1)C(N)=O
Show InChI InChI=1S/C12H10N4OS/c1-18-12-15-4-6-2-3-7-8(11(13)17)5-14-10(7)9(6)16-12/h2-5,14H,1H3,(H2,13,17)
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n/an/a 13n/an/an/an/a3.0n/a



Nerviano Medical Sciences S.r.l.

US Patent


Assay Description
Specific peptide or protein substrates are trans-phosphorylated by their specific ser-thr or tyr kinase in the presence of ATP traced with 33P-gamma-...

US Patent US8975267 (2015)


BindingDB Entry DOI: 10.7270/Q29C6W41
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))		BDBM149686
PNG
(US8975267, 22)
Show SMILES CSc1ncc2CCc3c(cn(C(C)C)c3-c2n1)C(N)=O
Show InChI InChI=1S/C15H18N4OS/c1-8(2)19-7-11(14(16)20)10-5-4-9-6-17-15(21-3)18-12(9)13(10)19/h6-8H,4-5H2,1-3H3,(H2,16,20)
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n/an/a 16n/an/an/an/a3.0n/a



Nerviano Medical Sciences S.r.l.

US Patent


Assay Description
Specific peptide or protein substrates are trans-phosphorylated by their specific ser-thr or tyr kinase in the presence of ATP traced with 33P-gamma-...

US Patent US8975267 (2015)


BindingDB Entry DOI: 10.7270/Q29C6W41
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))		BDBM149693
PNG
(US8975267, 35)
Show SMILES CSc1ncc2ccc3c(cn(C4CCNCC4)c3c2n1)C(N)=O
Show InChI InChI=1S/C17H19N5OS/c1-24-17-20-8-10-2-3-12-13(16(18)23)9-22(15(12)14(10)21-17)11-4-6-19-7-5-11/h2-3,8-9,11,19H,4-7H2,1H3,(H2,18,23)
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n/an/a 23n/an/an/an/a7.5n/a



Nerviano Medical Sciences S.r.l.

US Patent


Assay Description
The buffer for PIM-2 assay was composed of HEPES 50 mM, at pH 7.5, with 1 mM MgCl2, 1 mM DTT, 3 microM Na3VO4, and 0.2 mg/mL BSAFull-length human PIM...

US Patent US8975267 (2015)


BindingDB Entry DOI: 10.7270/Q29C6W41
More data for this
Ligand-Target Pair
Dual specificity protein kinase TTK


(Homo sapiens (Human))		BDBM149685
PNG
(US8975267, 7)
Show SMILES COc1cc(ccc1Nc1ncc2CCc3c(C(N)=O)c(C)n(C)c3-c2n1)N1CCN(C)CC1
Show InChI InChI=1S/C25H31N7O2/c1-15-21(24(26)33)18-7-5-16-14-27-25(29-22(16)23(18)31(15)3)28-19-8-6-17(13-20(19)34-4)32-11-9-30(2)10-12-32/h6,8,13-14H,5,7,9-12H2,1-4H3,(H2,26,33)(H,27,28,29)
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n/an/a 23n/an/an/an/a3.0n/a



Nerviano Medical Sciences S.r.l.

US Patent


Assay Description
Specific peptide or protein substrates are trans-phosphorylated by their specific ser-thr or tyr kinase in the presence of ATP traced with 33P-gamma-...

US Patent US8975267 (2015)


BindingDB Entry DOI: 10.7270/Q29C6W41
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))		BDBM149686
PNG
(US8975267, 22)
Show SMILES CSc1ncc2CCc3c(cn(C(C)C)c3-c2n1)C(N)=O
Show InChI InChI=1S/C15H18N4OS/c1-8(2)19-7-11(14(16)20)10-5-4-9-6-17-15(21-3)18-12(9)13(10)19/h6-8H,4-5H2,1-3H3,(H2,16,20)
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n/an/a 24n/an/an/an/a7.5n/a



Nerviano Medical Sciences S.r.l.

US Patent


Assay Description
The buffer for PIM-2 assay was composed of HEPES 50 mM, at pH 7.5, with 1 mM MgCl2, 1 mM DTT, 3 microM Na3VO4, and 0.2 mg/mL BSAFull-length human PIM...

US Patent US8975267 (2015)


BindingDB Entry DOI: 10.7270/Q29C6W41
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))		BDBM149695
PNG
(US8975267, 38)
Show SMILES CSc1ncc2ccc3c(cn(CC(C)(C)CN)c3c2n1)C(N)=O
Show InChI InChI=1S/C17H21N5OS/c1-17(2,8-18)9-22-7-12(15(19)23)11-5-4-10-6-20-16(24-3)21-13(10)14(11)22/h4-7H,8-9,18H2,1-3H3,(H2,19,23)
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n/an/a 24n/an/an/an/a3.0n/a



Nerviano Medical Sciences S.r.l.

US Patent


Assay Description
Specific peptide or protein substrates are trans-phosphorylated by their specific ser-thr or tyr kinase in the presence of ATP traced with 33P-gamma-...

US Patent US8975267 (2015)


BindingDB Entry DOI: 10.7270/Q29C6W41
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))		BDBM149695
PNG
(US8975267, 38)
Show SMILES CSc1ncc2ccc3c(cn(CC(C)(C)CN)c3c2n1)C(N)=O
Show InChI InChI=1S/C17H21N5OS/c1-17(2,8-18)9-22-7-12(15(19)23)11-5-4-10-6-20-16(24-3)21-13(10)14(11)22/h4-7H,8-9,18H2,1-3H3,(H2,19,23)
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n/an/a 34n/an/an/an/a7.5n/a



Nerviano Medical Sciences S.r.l.

US Patent


Assay Description
The buffer for PIM-2 assay was composed of HEPES 50 mM, at pH 7.5, with 1 mM MgCl2, 1 mM DTT, 3 microM Na3VO4, and 0.2 mg/mL BSAFull-length human PIM...

US Patent US8975267 (2015)


BindingDB Entry DOI: 10.7270/Q29C6W41
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))		BDBM149694
PNG
(US8975267, 36)
Show SMILES CSc1ncc2ccc3c(c[nH]c3c2n1)C(N)=O
Show InChI InChI=1S/C12H10N4OS/c1-18-12-15-4-6-2-3-7-8(11(13)17)5-14-10(7)9(6)16-12/h2-5,14H,1H3,(H2,13,17)
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n/an/a 46n/an/an/an/a7.5n/a



Nerviano Medical Sciences S.r.l.

US Patent


Assay Description
The buffer for PIM-2 assay was composed of HEPES 50 mM, at pH 7.5, with 1 mM MgCl2, 1 mM DTT, 3 microM Na3VO4, and 0.2 mg/mL BSAFull-length human PIM...

US Patent US8975267 (2015)


BindingDB Entry DOI: 10.7270/Q29C6W41
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))		BDBM149690
PNG
(US8975267, 32)
Show SMILES CSc1ncc2CCc3c(cn(C4CCNCC4)c3-c2n1)C(N)=O
Show InChI InChI=1S/C17H21N5OS/c1-24-17-20-8-10-2-3-12-13(16(18)23)9-22(15(12)14(10)21-17)11-4-6-19-7-5-11/h8-9,11,19H,2-7H2,1H3,(H2,18,23)
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n/an/a 74n/an/an/an/a3.0n/a



Nerviano Medical Sciences S.r.l.

US Patent


Assay Description
Specific peptide or protein substrates are trans-phosphorylated by their specific ser-thr or tyr kinase in the presence of ATP traced with 33P-gamma-...

US Patent US8975267 (2015)


BindingDB Entry DOI: 10.7270/Q29C6W41
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))		BDBM149688
PNG
(US8975267, 29)
Show SMILES CSc1ncc2ccc3c(C(N)=O)c(C)n(CCO)c3c2n1
Show InChI InChI=1S/C15H16N4O2S/c1-8-11(14(16)21)10-4-3-9-7-17-15(22-2)18-12(9)13(10)19(8)5-6-20/h3-4,7,20H,5-6H2,1-2H3,(H2,16,21)
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n/an/a 87n/an/an/an/a3.0n/a



Nerviano Medical Sciences S.r.l.

US Patent


Assay Description
Specific peptide or protein substrates are trans-phosphorylated by their specific ser-thr or tyr kinase in the presence of ATP traced with 33P-gamma-...

US Patent US8975267 (2015)


BindingDB Entry DOI: 10.7270/Q29C6W41
More data for this
Ligand-Target Pair
Dual specificity protein kinase TTK


(Homo sapiens (Human))		BDBM149684
PNG
(US8975267, 3)
Show SMILES CCc1cccc(CC)c1NC(=O)c1c(C)n(C)c-2c1CCc1cnc(Nc3ccc(cc3OC)N3CCC(CC3)N3CCCC3)nc-21
Show InChI InChI=1S/C39H49N7O2/c1-6-26-11-10-12-27(7-2)35(26)42-38(47)34-25(3)44(4)37-31(34)15-13-28-24-40-39(43-36(28)37)41-32-16-14-30(23-33(32)48-5)46-21-17-29(18-22-46)45-19-8-9-20-45/h10-12,14,16,23-24,29H,6-9,13,15,17-22H2,1-5H3,(H,42,47)(H,40,41,43)
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n/an/a 99n/an/an/an/a3.0n/a



Nerviano Medical Sciences S.r.l.

US Patent


Assay Description
Specific peptide or protein substrates are trans-phosphorylated by their specific ser-thr or tyr kinase in the presence of ATP traced with 33P-gamma-...

US Patent US8975267 (2015)


BindingDB Entry DOI: 10.7270/Q29C6W41
More data for this
Ligand-Target Pair
Dual specificity protein kinase TTK


(Homo sapiens (Human))		BDBM47183
PNG
(US8975267, 16)
Show SMILES CCc1cccc(CC)c1NC(=O)c1cn(C)c-2c1CCCc1cnc(Nc3ccc(cc3OC)N3CCN(C)CC3)nc-21
Show InChI InChI=1S/C35H43N7O2/c1-6-23-10-8-11-24(7-2)31(23)38-34(43)28-22-41(4)33-27(28)13-9-12-25-21-36-35(39-32(25)33)37-29-15-14-26(20-30(29)44-5)42-18-16-40(3)17-19-42/h8,10-11,14-15,20-22H,6-7,9,12-13,16-19H2,1-5H3,(H,38,43)(H,36,37,39)
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n/an/a 132n/an/an/an/a7.5n/a



Nerviano Medical Sciences S.r.l.

US Patent


Assay Description
The buffer for PIM-2 assay was composed of HEPES 50 mM, at pH 7.5, with 1 mM MgCl2, 1 mM DTT, 3 microM Na3VO4, and 0.2 mg/mL BSAFull-length human PIM...

US Patent US8975267 (2015)


BindingDB Entry DOI: 10.7270/Q29C6W41
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))		BDBM149687
PNG
(US8975267, 25)
Show SMILES CSc1ncc2CCc3c(cn(CCO)c3-c2n1)C(N)=O
Show InChI InChI=1S/C14H16N4O2S/c1-21-14-16-6-8-2-3-9-10(13(15)20)7-18(4-5-19)12(9)11(8)17-14/h6-7,19H,2-5H2,1H3,(H2,15,20)
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n/an/a 133n/an/an/an/a3.0n/a



Nerviano Medical Sciences S.r.l.

US Patent


Assay Description
Specific peptide or protein substrates are trans-phosphorylated by their specific ser-thr or tyr kinase in the presence of ATP traced with 33P-gamma-...

US Patent US8975267 (2015)


BindingDB Entry DOI: 10.7270/Q29C6W41
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))		BDBM149690
PNG
(US8975267, 32)
Show SMILES CSc1ncc2CCc3c(cn(C4CCNCC4)c3-c2n1)C(N)=O
Show InChI InChI=1S/C17H21N5OS/c1-24-17-20-8-10-2-3-12-13(16(18)23)9-22(15(12)14(10)21-17)11-4-6-19-7-5-11/h8-9,11,19H,2-7H2,1H3,(H2,18,23)
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n/an/a 159n/an/an/an/a7.5n/a



Nerviano Medical Sciences S.r.l.

US Patent


Assay Description
The buffer for PIM-2 assay was composed of HEPES 50 mM, at pH 7.5, with 1 mM MgCl2, 1 mM DTT, 3 microM Na3VO4, and 0.2 mg/mL BSAFull-length human PIM...

US Patent US8975267 (2015)


BindingDB Entry DOI: 10.7270/Q29C6W41
More data for this
Ligand-Target Pair
Dual specificity protein kinase TTK


(Homo sapiens (Human))		BDBM149686
PNG
(US8975267, 22)
Show SMILES CSc1ncc2CCc3c(cn(C(C)C)c3-c2n1)C(N)=O
Show InChI InChI=1S/C15H18N4OS/c1-8(2)19-7-11(14(16)20)10-5-4-9-6-17-15(21-3)18-12(9)13(10)19/h6-8H,4-5H2,1-3H3,(H2,16,20)
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n/an/a 382n/an/an/an/a3.0n/a



Nerviano Medical Sciences S.r.l.

US Patent


Assay Description
Specific peptide or protein substrates are trans-phosphorylated by their specific ser-thr or tyr kinase in the presence of ATP traced with 33P-gamma-...

US Patent US8975267 (2015)


BindingDB Entry DOI: 10.7270/Q29C6W41
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))		BDBM149688
PNG
(US8975267, 29)
Show SMILES CSc1ncc2ccc3c(C(N)=O)c(C)n(CCO)c3c2n1
Show InChI InChI=1S/C15H16N4O2S/c1-8-11(14(16)21)10-4-3-9-7-17-15(22-2)18-12(9)13(10)19(8)5-6-20/h3-4,7,20H,5-6H2,1-2H3,(H2,16,21)
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n/an/a 408n/an/an/an/a7.5n/a



Nerviano Medical Sciences S.r.l.

US Patent


Assay Description
The buffer for PIM-2 assay was composed of HEPES 50 mM, at pH 7.5, with 1 mM MgCl2, 1 mM DTT, 3 microM Na3VO4, and 0.2 mg/mL BSAFull-length human PIM...

US Patent US8975267 (2015)


BindingDB Entry DOI: 10.7270/Q29C6W41
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))		BDBM149687
PNG
(US8975267, 25)
Show SMILES CSc1ncc2CCc3c(cn(CCO)c3-c2n1)C(N)=O
Show InChI InChI=1S/C14H16N4O2S/c1-21-14-16-6-8-2-3-9-10(13(15)20)7-18(4-5-19)12(9)11(8)17-14/h6-7,19H,2-5H2,1H3,(H2,15,20)
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n/an/a 540n/an/an/an/a7.5n/a



Nerviano Medical Sciences S.r.l.

US Patent


Assay Description
The buffer for PIM-2 assay was composed of HEPES 50 mM, at pH 7.5, with 1 mM MgCl2, 1 mM DTT, 3 microM Na3VO4, and 0.2 mg/mL BSAFull-length human PIM...

US Patent US8975267 (2015)


BindingDB Entry DOI: 10.7270/Q29C6W41
More data for this
Ligand-Target Pair
Dual specificity protein kinase TTK


(Homo sapiens (Human))		BDBM149689
PNG
(US8975267, 30)
Show SMILES CSc1ncc2ccc3c(C(N)=O)c(C)n(C(C)C)c3c2n1
Show InChI InChI=1S/C16H18N4OS/c1-8(2)20-9(3)12(15(17)21)11-6-5-10-7-18-16(22-4)19-13(10)14(11)20/h5-8H,1-4H3,(H2,17,21)
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n/an/a 622n/an/an/an/a3.0n/a



Nerviano Medical Sciences S.r.l.

US Patent


Assay Description
Specific peptide or protein substrates are trans-phosphorylated by their specific ser-thr or tyr kinase in the presence of ATP traced with 33P-gamma-...

US Patent US8975267 (2015)


BindingDB Entry DOI: 10.7270/Q29C6W41
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))		BDBM149685
PNG
(US8975267, 7)
Show SMILES COc1cc(ccc1Nc1ncc2CCc3c(C(N)=O)c(C)n(C)c3-c2n1)N1CCN(C)CC1
Show InChI InChI=1S/C25H31N7O2/c1-15-21(24(26)33)18-7-5-16-14-27-25(29-22(16)23(18)31(15)3)28-19-8-6-17(13-20(19)34-4)32-11-9-30(2)10-12-32/h6,8,13-14H,5,7,9-12H2,1-4H3,(H2,26,33)(H,27,28,29)
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n/an/a 748n/an/an/an/a3.0n/a



Nerviano Medical Sciences S.r.l.

US Patent


Assay Description
Specific peptide or protein substrates are trans-phosphorylated by their specific ser-thr or tyr kinase in the presence of ATP traced with 33P-gamma-...

US Patent US8975267 (2015)


BindingDB Entry DOI: 10.7270/Q29C6W41
More data for this
Ligand-Target Pair
Dual specificity protein kinase TTK


(Homo sapiens (Human))		BDBM149694
PNG
(US8975267, 36)
Show SMILES CSc1ncc2ccc3c(c[nH]c3c2n1)C(N)=O
Show InChI InChI=1S/C12H10N4OS/c1-18-12-15-4-6-2-3-7-8(11(13)17)5-14-10(7)9(6)16-12/h2-5,14H,1H3,(H2,13,17)
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n/an/a 814n/an/an/an/a3.0n/a



Nerviano Medical Sciences S.r.l.

US Patent


Assay Description
Specific peptide or protein substrates are trans-phosphorylated by their specific ser-thr or tyr kinase in the presence of ATP traced with 33P-gamma-...

US Patent US8975267 (2015)


BindingDB Entry DOI: 10.7270/Q29C6W41
More data for this
Ligand-Target Pair
Dual specificity protein kinase TTK


(Homo sapiens (Human))		BDBM149692
PNG
(US8975267, 34)
Show SMILES CSc1ncc2ccc3c(cn([C@@H]4CC[C@H](N)CC4)c3c2n1)C(N)=O |wU:15.15,12.11,(6.59,1.87,;5.05,1.92,;4.24,.61,;4.97,-.75,;4.16,-2.06,;2.62,-2.01,;1.81,-3.32,;.27,-3.27,;-.46,-1.92,;-1.96,-1.55,;-2.07,-.01,;-.64,.57,;-.28,2.07,;1.2,2.49,;1.57,3.99,;.46,5.06,;.82,6.55,;-1.02,4.63,;-1.39,3.13,;.35,-.61,;1.89,-.65,;2.7,.65,;-3.13,-2.54,;-2.86,-4.06,;-4.58,-2.02,)|
Show InChI InChI=1S/C18H21N5OS/c1-25-18-21-8-10-2-7-13-14(17(20)24)9-23(16(13)15(10)22-18)12-5-3-11(19)4-6-12/h2,7-9,11-12H,3-6,19H2,1H3,(H2,20,24)/t11-,12+
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n/an/a 855n/an/an/an/a3.0n/a



Nerviano Medical Sciences S.r.l.

US Patent


Assay Description
Specific peptide or protein substrates are trans-phosphorylated by their specific ser-thr or tyr kinase in the presence of ATP traced with 33P-gamma-...

US Patent US8975267 (2015)


BindingDB Entry DOI: 10.7270/Q29C6W41
More data for this
Ligand-Target Pair
Dual specificity protein kinase TTK


(Homo sapiens (Human))		BDBM149691
PNG
(US8975267, 33)
Show SMILES CSc1ncc2CCc3c(cn([C@@H]4CC[C@H](N)CC4)c3-c2n1)C(N)=O |wU:15.15,12.11,(6.59,1.87,;5.05,1.92,;4.24,.61,;4.97,-.75,;4.16,-2.06,;2.62,-2.01,;1.81,-3.32,;.27,-3.27,;-.46,-1.92,;-1.96,-1.55,;-2.07,-.01,;-.64,.57,;-.28,2.07,;1.2,2.49,;1.57,3.99,;.46,5.06,;.82,6.55,;-1.02,4.63,;-1.39,3.13,;.35,-.61,;1.89,-.65,;2.7,.65,;-3.13,-2.54,;-2.86,-4.06,;-4.58,-2.02,)|
Show InChI InChI=1S/C18H23N5OS/c1-25-18-21-8-10-2-7-13-14(17(20)24)9-23(16(13)15(10)22-18)12-5-3-11(19)4-6-12/h8-9,11-12H,2-7,19H2,1H3,(H2,20,24)/t11-,12+
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n/an/a 1.55E+3n/an/an/an/a3.0n/a



Nerviano Medical Sciences S.r.l.

US Patent


Assay Description
Specific peptide or protein substrates are trans-phosphorylated by their specific ser-thr or tyr kinase in the presence of ATP traced with 33P-gamma-...

US Patent US8975267 (2015)


BindingDB Entry DOI: 10.7270/Q29C6W41
More data for this
Ligand-Target Pair
Dual specificity protein kinase TTK


(Homo sapiens (Human))		BDBM149687
PNG
(US8975267, 25)
Show SMILES CSc1ncc2CCc3c(cn(CCO)c3-c2n1)C(N)=O
Show InChI InChI=1S/C14H16N4O2S/c1-21-14-16-6-8-2-3-9-10(13(15)20)7-18(4-5-19)12(9)11(8)17-14/h6-7,19H,2-5H2,1H3,(H2,15,20)
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n/an/a 2.44E+3n/an/an/an/a3.0n/a



Nerviano Medical Sciences S.r.l.

US Patent


Assay Description
Specific peptide or protein substrates are trans-phosphorylated by their specific ser-thr or tyr kinase in the presence of ATP traced with 33P-gamma-...

US Patent US8975267 (2015)


BindingDB Entry DOI: 10.7270/Q29C6W41
More data for this
Ligand-Target Pair
Dual specificity protein kinase TTK


(Homo sapiens (Human))		BDBM149688
PNG
(US8975267, 29)
Show SMILES CSc1ncc2ccc3c(C(N)=O)c(C)n(CCO)c3c2n1
Show InChI InChI=1S/C15H16N4O2S/c1-8-11(14(16)21)10-4-3-9-7-17-15(22-2)18-12(9)13(10)19(8)5-6-20/h3-4,7,20H,5-6H2,1-2H3,(H2,16,21)
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n/an/a 2.94E+3n/an/an/an/a3.0n/a



Nerviano Medical Sciences S.r.l.

US Patent


Assay Description
Specific peptide or protein substrates are trans-phosphorylated by their specific ser-thr or tyr kinase in the presence of ATP traced with 33P-gamma-...

US Patent US8975267 (2015)


BindingDB Entry DOI: 10.7270/Q29C6W41
More data for this
Ligand-Target Pair
Dual specificity protein kinase TTK


(Homo sapiens (Human))		BDBM149695
PNG
(US8975267, 38)
Show SMILES CSc1ncc2ccc3c(cn(CC(C)(C)CN)c3c2n1)C(N)=O
Show InChI InChI=1S/C17H21N5OS/c1-17(2,8-18)9-22-7-12(15(19)23)11-5-4-10-6-20-16(24-3)21-13(10)14(11)22/h4-7H,8-9,18H2,1-3H3,(H2,19,23)
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n/an/a 2.94E+3n/an/an/an/a3.0n/a



Nerviano Medical Sciences S.r.l.

US Patent


Assay Description
Specific peptide or protein substrates are trans-phosphorylated by their specific ser-thr or tyr kinase in the presence of ATP traced with 33P-gamma-...

US Patent US8975267 (2015)


BindingDB Entry DOI: 10.7270/Q29C6W41
More data for this
Ligand-Target Pair
Dual specificity protein kinase TTK


(Homo sapiens (Human))		BDBM149693
PNG
(US8975267, 35)
Show SMILES CSc1ncc2ccc3c(cn(C4CCNCC4)c3c2n1)C(N)=O
Show InChI InChI=1S/C17H19N5OS/c1-24-17-20-8-10-2-3-12-13(16(18)23)9-22(15(12)14(10)21-17)11-4-6-19-7-5-11/h2-3,8-9,11,19H,4-7H2,1H3,(H2,18,23)
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n/an/a 4.55E+3n/an/an/an/a3.0n/a



Nerviano Medical Sciences S.r.l.

US Patent


Assay Description
Specific peptide or protein substrates are trans-phosphorylated by their specific ser-thr or tyr kinase in the presence of ATP traced with 33P-gamma-...

US Patent US8975267 (2015)


BindingDB Entry DOI: 10.7270/Q29C6W41
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))		BDBM149683
PNG
(US8975267, Ref. compound 4)
Show SMILES Cn1c(c(C(N)=O)c2ccc3cnc(N)nc3c12)-c1ccccc1
Show InChI InChI=1S/C18H15N5O/c1-23-15(10-5-3-2-4-6-10)13(17(19)24)12-8-7-11-9-21-18(20)22-14(11)16(12)23/h2-9H,1H3,(H2,19,24)(H2,20,21,22)
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n/an/a>5.00E+3n/an/an/an/a3.0n/a



Nerviano Medical Sciences S.r.l.

US Patent


Assay Description
Specific peptide or protein substrates are trans-phosphorylated by their specific ser-thr or tyr kinase in the presence of ATP traced with 33P-gamma-...

US Patent US8975267 (2015)


BindingDB Entry DOI: 10.7270/Q29C6W41
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))		BDBM149685
PNG
(US8975267, 7)
Show SMILES COc1cc(ccc1Nc1ncc2CCc3c(C(N)=O)c(C)n(C)c3-c2n1)N1CCN(C)CC1
Show InChI InChI=1S/C25H31N7O2/c1-15-21(24(26)33)18-7-5-16-14-27-25(29-22(16)23(18)31(15)3)28-19-8-6-17(13-20(19)34-4)32-11-9-30(2)10-12-32/h6,8,13-14H,5,7,9-12H2,1-4H3,(H2,26,33)(H,27,28,29)
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n/an/a>5.00E+3n/an/an/an/a7.5n/a



Nerviano Medical Sciences S.r.l.

US Patent


Assay Description
The buffer for PIM-2 assay was composed of HEPES 50 mM, at pH 7.5, with 1 mM MgCl2, 1 mM DTT, 3 microM Na3VO4, and 0.2 mg/mL BSAFull-length human PIM...

US Patent US8975267 (2015)


BindingDB Entry DOI: 10.7270/Q29C6W41
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))		BDBM149681
PNG
(US8975267, Ref. compound 2)
Show SMILES NC(=O)c1c([nH]c2c1ccc1cnc(N)nc21)-c1ccccc1
Show InChI InChI=1S/C17H13N5O/c18-16(23)12-11-7-6-10-8-20-17(19)22-14(10)15(11)21-13(12)9-4-2-1-3-5-9/h1-8,21H,(H2,18,23)(H2,19,20,22)
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n/an/a>5.00E+3n/an/an/an/a3.0n/a



Nerviano Medical Sciences S.r.l.

US Patent


Assay Description
Specific peptide or protein substrates are trans-phosphorylated by their specific ser-thr or tyr kinase in the presence of ATP traced with 33P-gamma-...

US Patent US8975267 (2015)


BindingDB Entry DOI: 10.7270/Q29C6W41
More data for this
Ligand-Target Pair
Dual specificity protein kinase TTK


(Homo sapiens (Human))		BDBM149681
PNG
(US8975267, Ref. compound 2)
Show SMILES NC(=O)c1c([nH]c2c1ccc1cnc(N)nc21)-c1ccccc1
Show InChI InChI=1S/C17H13N5O/c18-16(23)12-11-7-6-10-8-20-17(19)22-14(10)15(11)21-13(12)9-4-2-1-3-5-9/h1-8,21H,(H2,18,23)(H2,19,20,22)
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n/an/a>5.00E+3n/an/an/an/a3.0n/a



Nerviano Medical Sciences S.r.l.

US Patent


Assay Description
Specific peptide or protein substrates are trans-phosphorylated by their specific ser-thr or tyr kinase in the presence of ATP traced with 33P-gamma-...

US Patent US8975267 (2015)


BindingDB Entry DOI: 10.7270/Q29C6W41
More data for this
Ligand-Target Pair
Dual specificity protein kinase TTK


(Homo sapiens (Human))		BDBM149683
PNG
(US8975267, Ref. compound 4)
Show SMILES Cn1c(c(C(N)=O)c2ccc3cnc(N)nc3c12)-c1ccccc1
Show InChI InChI=1S/C18H15N5O/c1-23-15(10-5-3-2-4-6-10)13(17(19)24)12-8-7-11-9-21-18(20)22-14(11)16(12)23/h2-9H,1H3,(H2,19,24)(H2,20,21,22)
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n/an/a>5.00E+3n/an/an/an/a3.0n/a



Nerviano Medical Sciences S.r.l.

US Patent


Assay Description
Specific peptide or protein substrates are trans-phosphorylated by their specific ser-thr or tyr kinase in the presence of ATP traced with 33P-gamma-...

US Patent US8975267 (2015)


BindingDB Entry DOI: 10.7270/Q29C6W41
More data for this
Ligand-Target Pair
Dual specificity protein kinase TTK


(Homo sapiens (Human))		BDBM149682
PNG
(US8975267, Ref. compound 3)
Show SMILES Cn1c(c(C(N)=O)c2CCc3cnc(N)nc3-c12)-c1ccccc1
Show InChI InChI=1S/C18H17N5O/c1-23-15(10-5-3-2-4-6-10)13(17(19)24)12-8-7-11-9-21-18(20)22-14(11)16(12)23/h2-6,9H,7-8H2,1H3,(H2,19,24)(H2,20,21,22)
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n/an/a>5.00E+3n/an/an/an/a3.0n/a



Nerviano Medical Sciences S.r.l.

US Patent


Assay Description
Specific peptide or protein substrates are trans-phosphorylated by their specific ser-thr or tyr kinase in the presence of ATP traced with 33P-gamma-...

US Patent US8975267 (2015)


BindingDB Entry DOI: 10.7270/Q29C6W41
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))		BDBM149682
PNG
(US8975267, Ref. compound 3)
Show SMILES Cn1c(c(C(N)=O)c2CCc3cnc(N)nc3-c12)-c1ccccc1
Show InChI InChI=1S/C18H17N5O/c1-23-15(10-5-3-2-4-6-10)13(17(19)24)12-8-7-11-9-21-18(20)22-14(11)16(12)23/h2-6,9H,7-8H2,1H3,(H2,19,24)(H2,20,21,22)
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n/an/a>5.00E+3n/an/an/an/a3.0n/a



Nerviano Medical Sciences S.r.l.

US Patent


Assay Description
Specific peptide or protein substrates are trans-phosphorylated by their specific ser-thr or tyr kinase in the presence of ATP traced with 33P-gamma-...

US Patent US8975267 (2015)


BindingDB Entry DOI: 10.7270/Q29C6W41
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))		BDBM149680
PNG
(US8975267, Ref. compound 1)
Show SMILES Cn1cc(C(N)=O)c2CCc3cnc(N)nc3-c12
Show InChI InChI=1S/C12H13N5O/c1-17-5-8(11(13)18)7-3-2-6-4-15-12(14)16-9(6)10(7)17/h4-5H,2-3H2,1H3,(H2,13,18)(H2,14,15,16)
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n/an/a>1.00E+4n/an/an/an/a7.5n/a



Nerviano Medical Sciences S.r.l.

US Patent


Assay Description
The buffer for PIM-2 assay was composed of HEPES 50 mM, at pH 7.5, with 1 mM MgCl2, 1 mM DTT, 3 microM Na3VO4, and 0.2 mg/mL BSAFull-length human PIM...

US Patent US8975267 (2015)


BindingDB Entry DOI: 10.7270/Q29C6W41
More data for this
Ligand-Target Pair
Dual specificity protein kinase TTK


(Homo sapiens (Human))		BDBM149680
PNG
(US8975267, Ref. compound 1)
Show SMILES Cn1cc(C(N)=O)c2CCc3cnc(N)nc3-c12
Show InChI InChI=1S/C12H13N5O/c1-17-5-8(11(13)18)7-3-2-6-4-15-12(14)16-9(6)10(7)17/h4-5H,2-3H2,1H3,(H2,13,18)(H2,14,15,16)
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n/an/a>1.00E+4n/an/an/an/a3.0n/a



Nerviano Medical Sciences S.r.l.

US Patent


Assay Description
Specific peptide or protein substrates are trans-phosphorylated by their specific ser-thr or tyr kinase in the presence of ATP traced with 33P-gamma-...

US Patent US8975267 (2015)


BindingDB Entry DOI: 10.7270/Q29C6W41
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))		BDBM149684
PNG
(US8975267, 3)
Show SMILES CCc1cccc(CC)c1NC(=O)c1c(C)n(C)c-2c1CCc1cnc(Nc3ccc(cc3OC)N3CCC(CC3)N3CCCC3)nc-21
Show InChI InChI=1S/C39H49N7O2/c1-6-26-11-10-12-27(7-2)35(26)42-38(47)34-25(3)44(4)37-31(34)15-13-28-24-40-39(43-36(28)37)41-32-16-14-30(23-33(32)48-5)46-21-17-29(18-22-46)45-19-8-9-20-45/h10-12,14,16,23-24,29H,6-9,13,15,17-22H2,1-5H3,(H,42,47)(H,40,41,43)
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n/an/a>1.00E+4n/an/an/an/a3.0n/a



Nerviano Medical Sciences S.r.l.

US Patent


Assay Description
Specific peptide or protein substrates are trans-phosphorylated by their specific ser-thr or tyr kinase in the presence of ATP traced with 33P-gamma-...

US Patent US8975267 (2015)


BindingDB Entry DOI: 10.7270/Q29C6W41
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))		BDBM149684
PNG
(US8975267, 3)
Show SMILES CCc1cccc(CC)c1NC(=O)c1c(C)n(C)c-2c1CCc1cnc(Nc3ccc(cc3OC)N3CCC(CC3)N3CCCC3)nc-21
Show InChI InChI=1S/C39H49N7O2/c1-6-26-11-10-12-27(7-2)35(26)42-38(47)34-25(3)44(4)37-31(34)15-13-28-24-40-39(43-36(28)37)41-32-16-14-30(23-33(32)48-5)46-21-17-29(18-22-46)45-19-8-9-20-45/h10-12,14,16,23-24,29H,6-9,13,15,17-22H2,1-5H3,(H,42,47)(H,40,41,43)
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n/an/a>1.00E+4n/an/an/an/a7.5n/a



Nerviano Medical Sciences S.r.l.

US Patent


Assay Description
The buffer for PIM-2 assay was composed of HEPES 50 mM, at pH 7.5, with 1 mM MgCl2, 1 mM DTT, 3 microM Na3VO4, and 0.2 mg/mL BSAFull-length human PIM...

US Patent US8975267 (2015)


BindingDB Entry DOI: 10.7270/Q29C6W41
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))		BDBM47183
PNG
(US8975267, 16)
Show SMILES CCc1cccc(CC)c1NC(=O)c1cn(C)c-2c1CCCc1cnc(Nc3ccc(cc3OC)N3CCN(C)CC3)nc-21
Show InChI InChI=1S/C35H43N7O2/c1-6-23-10-8-11-24(7-2)31(23)38-34(43)28-22-41(4)33-27(28)13-9-12-25-21-36-35(39-32(25)33)37-29-15-14-26(20-30(29)44-5)42-18-16-40(3)17-19-42/h8,10-11,14-15,20-22H,6-7,9,12-13,16-19H2,1-5H3,(H,38,43)(H,36,37,39)
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n/an/a>1.00E+4n/an/an/an/a7.5n/a



Nerviano Medical Sciences S.r.l.

US Patent


Assay Description
The buffer for PIM-2 assay was composed of HEPES 50 mM, at pH 7.5, with 1 mM MgCl2, 1 mM DTT, 3 microM Na3VO4, and 0.2 mg/mL BSAFull-length human PIM...

US Patent US8975267 (2015)


BindingDB Entry DOI: 10.7270/Q29C6W41
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))		BDBM149682
PNG
(US8975267, Ref. compound 3)
Show SMILES Cn1c(c(C(N)=O)c2CCc3cnc(N)nc3-c12)-c1ccccc1
Show InChI InChI=1S/C18H17N5O/c1-23-15(10-5-3-2-4-6-10)13(17(19)24)12-8-7-11-9-21-18(20)22-14(11)16(12)23/h2-6,9H,7-8H2,1H3,(H2,19,24)(H2,20,21,22)
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n/an/a>1.00E+4n/an/an/an/a7.5n/a



Nerviano Medical Sciences S.r.l.

US Patent


Assay Description
The buffer for PIM-2 assay was composed of HEPES 50 mM, at pH 7.5, with 1 mM MgCl2, 1 mM DTT, 3 microM Na3VO4, and 0.2 mg/mL BSAFull-length human PIM...

US Patent US8975267 (2015)


BindingDB Entry DOI: 10.7270/Q29C6W41
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))		BDBM47183
PNG
(US8975267, 16)
Show SMILES CCc1cccc(CC)c1NC(=O)c1cn(C)c-2c1CCCc1cnc(Nc3ccc(cc3OC)N3CCN(C)CC3)nc-21
Show InChI InChI=1S/C35H43N7O2/c1-6-23-10-8-11-24(7-2)31(23)38-34(43)28-22-41(4)33-27(28)13-9-12-25-21-36-35(39-32(25)33)37-29-15-14-26(20-30(29)44-5)42-18-16-40(3)17-19-42/h8,10-11,14-15,20-22H,6-7,9,12-13,16-19H2,1-5H3,(H,38,43)(H,36,37,39)
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n/an/a>1.00E+4n/an/an/an/a7.5n/a



Nerviano Medical Sciences S.r.l.

US Patent


Assay Description
The buffer for PIM-2 assay was composed of HEPES 50 mM, at pH 7.5, with 1 mM MgCl2, 1 mM DTT, 3 microM Na3VO4, and 0.2 mg/mL BSAFull-length human PIM...

US Patent US8975267 (2015)


BindingDB Entry DOI: 10.7270/Q29C6W41
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))		BDBM149681
PNG
(US8975267, Ref. compound 2)
Show SMILES NC(=O)c1c([nH]c2c1ccc1cnc(N)nc21)-c1ccccc1
Show InChI InChI=1S/C17H13N5O/c18-16(23)12-11-7-6-10-8-20-17(19)22-14(10)15(11)21-13(12)9-4-2-1-3-5-9/h1-8,21H,(H2,18,23)(H2,19,20,22)
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n/an/a>1.00E+4n/an/an/an/a7.5n/a



Nerviano Medical Sciences S.r.l.

US Patent


Assay Description
The buffer for PIM-2 assay was composed of HEPES 50 mM, at pH 7.5, with 1 mM MgCl2, 1 mM DTT, 3 microM Na3VO4, and 0.2 mg/mL BSAFull-length human PIM...

US Patent US8975267 (2015)


BindingDB Entry DOI: 10.7270/Q29C6W41
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))		BDBM149680
PNG
(US8975267, Ref. compound 1)
Show SMILES Cn1cc(C(N)=O)c2CCc3cnc(N)nc3-c12
Show InChI InChI=1S/C12H13N5O/c1-17-5-8(11(13)18)7-3-2-6-4-15-12(14)16-9(6)10(7)17/h4-5H,2-3H2,1H3,(H2,13,18)(H2,14,15,16)
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n/an/a>1.00E+4n/an/an/an/a3.0n/a



Nerviano Medical Sciences S.r.l.

US Patent


Assay Description
Specific peptide or protein substrates are trans-phosphorylated by their specific ser-thr or tyr kinase in the presence of ATP traced with 33P-gamma-...

US Patent US8975267 (2015)


BindingDB Entry DOI: 10.7270/Q29C6W41
More data for this
Ligand-Target Pair
Dual specificity protein kinase TTK


(Homo sapiens (Human))		BDBM149690
PNG
(US8975267, 32)
Show SMILES CSc1ncc2CCc3c(cn(C4CCNCC4)c3-c2n1)C(N)=O
Show InChI InChI=1S/C17H21N5OS/c1-24-17-20-8-10-2-3-12-13(16(18)23)9-22(15(12)14(10)21-17)11-4-6-19-7-5-11/h8-9,11,19H,2-7H2,1H3,(H2,18,23)
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n/an/a>1.00E+4n/an/an/an/a3.0n/a



Nerviano Medical Sciences S.r.l.

US Patent


Assay Description
Specific peptide or protein substrates are trans-phosphorylated by their specific ser-thr or tyr kinase in the presence of ATP traced with 33P-gamma-...

US Patent US8975267 (2015)


BindingDB Entry DOI: 10.7270/Q29C6W41
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))		BDBM149683
PNG
(US8975267, Ref. compound 4)
Show SMILES Cn1c(c(C(N)=O)c2ccc3cnc(N)nc3c12)-c1ccccc1
Show InChI InChI=1S/C18H15N5O/c1-23-15(10-5-3-2-4-6-10)13(17(19)24)12-8-7-11-9-21-18(20)22-14(11)16(12)23/h2-9H,1H3,(H2,19,24)(H2,20,21,22)
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n/an/a>1.00E+4n/an/an/an/a7.5n/a



Nerviano Medical Sciences S.r.l.

US Patent


Assay Description
The buffer for PIM-2 assay was composed of HEPES 50 mM, at pH 7.5, with 1 mM MgCl2, 1 mM DTT, 3 microM Na3VO4, and 0.2 mg/mL BSAFull-length human PIM...

US Patent US8975267 (2015)


BindingDB Entry DOI: 10.7270/Q29C6W41
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%