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USPatent US9066954

Compile data set for download or QSAR
Found 107 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM164488
PNG
(US9066954, 373)
Show SMILES Fc1cc(F)cc(c1)-c1ccc2nnc(CNc3ccnc4cc(OCCn5cncn5)cnc34)n2n1
Show InChI InChI=1S/C24H18F2N10O/c25-16-7-15(8-17(26)9-16)19-1-2-22-32-33-23(36(22)34-19)12-29-20-3-4-28-21-10-18(11-30-24(20)21)37-6-5-35-14-27-13-31-35/h1-4,7-11,13-14H,5-6,12H2,(H,28,29)
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US Patent
 0.100 -57.5n/an/an/an/an/a8.027



Amgen Inc.

US Patent


Assay Description
A PCR product covering residues 1058-1365 of c-Met (c-Met kinase domain) is generated from Human Liver QuickClone cDNA (Invitrogen) using forward pri...

US Patent US9066954 (2015)


BindingDB Entry DOI: 10.7270/Q2N878JD
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM164473
PNG
(US9066954, 302)
Show SMILES COc1ccc2c(OCc3nnc4c(F)cc(cn34)-c3cc(C)cs3)ccnc2c1
Show InChI InChI=1S/C22H17FN4O2S/c1-13-7-20(30-12-13)14-8-17(23)22-26-25-21(27(22)10-14)11-29-19-5-6-24-18-9-15(28-2)3-4-16(18)19/h3-10,12H,11H2,1-2H3
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US Patent
 0.300 -54.7n/an/an/an/an/a8.027



Amgen Inc.

US Patent


Assay Description
A PCR product covering residues 1058-1365 of c-Met (c-Met kinase domain) is generated from Human Liver QuickClone cDNA (Invitrogen) using forward pri...

US Patent US9066954 (2015)


BindingDB Entry DOI: 10.7270/Q2N878JD
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM164486
PNG
(US9066954, 336)
Show SMILES Cc1csc(c1)-c1ccc2nnc(Cc3ccc4ncccc4c3)n2n1
Show InChI InChI=1S/C20H15N5S/c1-13-9-18(26-12-13)17-6-7-19-22-23-20(25(19)24-17)11-14-4-5-16-15(10-14)3-2-8-21-16/h2-10,12H,11H2,1H3
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US Patent
 0.700 -52.6n/an/an/an/an/a8.027



Amgen Inc.

US Patent


Assay Description
A PCR product covering residues 1058-1365 of c-Met (c-Met kinase domain) is generated from Human Liver QuickClone cDNA (Invitrogen) using forward pri...

US Patent US9066954 (2015)


BindingDB Entry DOI: 10.7270/Q2N878JD
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM164420
PNG
(US9066954, 55)
Show SMILES COc1cnc2c(NCc3nnc4ncc(nn34)-c3ccccc3)ccnc2c1
Show InChI InChI=1S/C20H16N8O/c1-29-14-9-16-19(23-10-14)15(7-8-21-16)22-12-18-25-26-20-24-11-17(27-28(18)20)13-5-3-2-4-6-13/h2-11H,12H2,1H3,(H,21,22)
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US Patent
 0.900 -52.0n/an/an/an/an/a8.027



Amgen Inc.

US Patent


Assay Description
A PCR product covering residues 1058-1365 of c-Met (c-Met kinase domain) is generated from Human Liver QuickClone cDNA (Invitrogen) using forward pri...

US Patent US9066954 (2015)


BindingDB Entry DOI: 10.7270/Q2N878JD
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM164453
PNG
(US9066954, 176)
Show SMILES COc1cnc2c(NCc3nnc4ccc(nn34)-c3cc(C)cs3)ccnc2c1
Show InChI InChI=1S/C20H17N7OS/c1-12-7-17(29-11-12)14-3-4-18-24-25-19(27(18)26-14)10-22-15-5-6-21-16-8-13(28-2)9-23-20(15)16/h3-9,11H,10H2,1-2H3,(H,21,22)
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US Patent
 1.20 -51.3n/an/an/an/an/a8.027



Amgen Inc.

US Patent


Assay Description
A PCR product covering residues 1058-1365 of c-Met (c-Met kinase domain) is generated from Human Liver QuickClone cDNA (Invitrogen) using forward pri...

US Patent US9066954 (2015)


BindingDB Entry DOI: 10.7270/Q2N878JD
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM24483
PNG
(5-(3-{[(7-methoxyquinolin-4-yl)oxy]methyl}-[1,2,4]...)
Show SMILES COc1ccc2c(OCc3nnc4ccc(nn34)-c3cc(C)ns3)ccnc2c1
Show InChI InChI=1S/C20H16N6O2S/c1-12-9-18(29-25-12)15-5-6-19-22-23-20(26(19)24-15)11-28-17-7-8-21-16-10-13(27-2)3-4-14(16)17/h3-10H,11H2,1-2H3
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US Patent
 1.60 -50.5n/an/an/an/an/a8.027



Amgen Inc.

US Patent


Assay Description
A PCR product covering residues 1058-1365 of c-Met (c-Met kinase domain) is generated from Human Liver QuickClone cDNA (Invitrogen) using forward pri...

US Patent US9066954 (2015)


BindingDB Entry DOI: 10.7270/Q2N878JD
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM164424
PNG
(US9066954, 62)
Show SMILES COc1cnc2c(OCc3cnc4ccc(nn34)-c3cc(F)c(F)c(F)c3)ccnc2c1
Show InChI InChI=1S/C22H14F3N5O2/c1-31-14-8-18-22(28-10-14)19(4-5-26-18)32-11-13-9-27-20-3-2-17(29-30(13)20)12-6-15(23)21(25)16(24)7-12/h2-10H,11H2,1H3
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US Patent
 1.70 -50.4n/an/an/an/an/a8.027



Amgen Inc.

US Patent


Assay Description
A PCR product covering residues 1058-1365 of c-Met (c-Met kinase domain) is generated from Human Liver QuickClone cDNA (Invitrogen) using forward pri...

US Patent US9066954 (2015)


BindingDB Entry DOI: 10.7270/Q2N878JD
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM164434
PNG
(US9066954, 85)
Show SMILES COc1ccc2c(OCc3nnc4c(F)cc(cn34)-c3cc(C)ns3)ccnc2c1
Show InChI InChI=1S/C21H16FN5O2S/c1-12-7-19(30-26-12)13-8-16(22)21-25-24-20(27(21)10-13)11-29-18-5-6-23-17-9-14(28-2)3-4-15(17)18/h3-10H,11H2,1-2H3
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 2 -50.0n/an/an/an/an/a8.027



Amgen Inc.

US Patent


Assay Description
A PCR product covering residues 1058-1365 of c-Met (c-Met kinase domain) is generated from Human Liver QuickClone cDNA (Invitrogen) using forward pri...

US Patent US9066954 (2015)


BindingDB Entry DOI: 10.7270/Q2N878JD
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM164475
PNG
(US9066954, 309)
Show SMILES COc1cnc2c(NCc3nnc4ccc(nn34)-c3ccc4ncsc4c3)ccnc2c1
Show InChI InChI=1S/C22H16N8OS/c1-31-14-9-18-22(25-10-14)17(6-7-23-18)24-11-21-28-27-20-5-4-15(29-30(20)21)13-2-3-16-19(8-13)32-12-26-16/h2-10,12H,11H2,1H3,(H,23,24)
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US Patent
 2 -50.0n/an/an/an/an/a8.027



Amgen Inc.

US Patent


Assay Description
A PCR product covering residues 1058-1365 of c-Met (c-Met kinase domain) is generated from Human Liver QuickClone cDNA (Invitrogen) using forward pri...

US Patent US9066954 (2015)


BindingDB Entry DOI: 10.7270/Q2N878JD
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM164430
PNG
(US9066954, 75)
Show SMILES CNC(=O)c1ccc(s1)-c1ccc2nnc(COc3ccnc4cc(OC)ccc34)n2c1
Show InChI InChI=1S/C23H19N5O3S/c1-24-23(29)20-7-6-19(32-20)14-3-8-21-26-27-22(28(21)12-14)13-31-18-9-10-25-17-11-15(30-2)4-5-16(17)18/h3-12H,13H2,1-2H3,(H,24,29)
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US Patent
 2.20 -49.7n/an/an/an/an/a8.027



Amgen Inc.

US Patent


Assay Description
A PCR product covering residues 1058-1365 of c-Met (c-Met kinase domain) is generated from Human Liver QuickClone cDNA (Invitrogen) using forward pri...

US Patent US9066954 (2015)


BindingDB Entry DOI: 10.7270/Q2N878JD
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM164457
PNG
(US9066954, 202)
Show SMILES COc1ccc2c(OCc3nnc4ccc(nn34)-c3ccc4NC(=O)CCc4c3)ccnc2c1
Show InChI InChI=1S/C25H20N6O3/c1-33-17-4-5-18-21(13-17)26-11-10-22(18)34-14-24-29-28-23-8-7-20(30-31(23)24)16-2-6-19-15(12-16)3-9-25(32)27-19/h2,4-8,10-13H,3,9,14H2,1H3,(H,27,32)
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US Patent
 2.40 -49.5n/an/an/an/an/a8.027



Amgen Inc.

US Patent


Assay Description
A PCR product covering residues 1058-1365 of c-Met (c-Met kinase domain) is generated from Human Liver QuickClone cDNA (Invitrogen) using forward pri...

US Patent US9066954 (2015)


BindingDB Entry DOI: 10.7270/Q2N878JD
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM164435
PNG
(US9066954, 86)
Show SMILES COc1ccc2c(OCc3nnc4c(F)cc(cn34)-c3cnc(C)s3)ccnc2c1
Show InChI InChI=1S/C21H16FN5O2S/c1-12-24-9-19(30-12)13-7-16(22)21-26-25-20(27(21)10-13)11-29-18-5-6-23-17-8-14(28-2)3-4-15(17)18/h3-10H,11H2,1-2H3
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US Patent
 2.40 -49.5n/an/an/an/an/a8.027



Amgen Inc.

US Patent


Assay Description
A PCR product covering residues 1058-1365 of c-Met (c-Met kinase domain) is generated from Human Liver QuickClone cDNA (Invitrogen) using forward pri...

US Patent US9066954 (2015)


BindingDB Entry DOI: 10.7270/Q2N878JD
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM164441
PNG
(US9066954, 118)
Show SMILES COc1cnc2ccc(cc2c1)[C@H](C)c1nnc2ccc(nn12)-c1ccccc1 |r|
Show InChI InChI=1S/C23H19N5O/c1-15(17-8-9-20-18(12-17)13-19(29-2)14-24-20)23-26-25-22-11-10-21(27-28(22)23)16-6-4-3-5-7-16/h3-15H,1-2H3/t15-/m0/s1
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US Patent
 2.60 -49.3n/an/an/an/an/a8.027



Amgen Inc.

US Patent


Assay Description
A PCR product covering residues 1058-1365 of c-Met (c-Met kinase domain) is generated from Human Liver QuickClone cDNA (Invitrogen) using forward pri...

US Patent US9066954 (2015)


BindingDB Entry DOI: 10.7270/Q2N878JD
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM164464
PNG
(US9066954, 232)
Show SMILES COc1ccc2c(OCc3nnc4ccc(nn34)-c3ccc4OCCOc4c3)ccnc2c1
Show InChI InChI=1S/C24H19N5O4/c1-30-16-3-4-17-19(13-16)25-9-8-20(17)33-14-24-27-26-23-7-5-18(28-29(23)24)15-2-6-21-22(12-15)32-11-10-31-21/h2-9,12-13H,10-11,14H2,1H3
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US Patent
 2.60 -49.3n/an/an/an/an/a8.027



Amgen Inc.

US Patent


Assay Description
A PCR product covering residues 1058-1365 of c-Met (c-Met kinase domain) is generated from Human Liver QuickClone cDNA (Invitrogen) using forward pri...

US Patent US9066954 (2015)


BindingDB Entry DOI: 10.7270/Q2N878JD
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM50302903
PNG
(7-methoxy-N-((6-(3,4,5-trifluorophenyl)-[1,2,4]tri...)
Show SMILES COc1cnc2c(NCc3nnc4ccc(nn34)-c3cc(F)c(F)c(F)c3)ccnc2c1
Show InChI InChI=1S/C21H14F3N7O/c1-32-12-8-17-21(27-9-12)16(4-5-25-17)26-10-19-29-28-18-3-2-15(30-31(18)19)11-6-13(22)20(24)14(23)7-11/h2-9H,10H2,1H3,(H,25,26)
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US Patent
 2.70 -49.2n/an/an/an/an/a8.027



Amgen Inc.

US Patent


Assay Description
A PCR product covering residues 1058-1365 of c-Met (c-Met kinase domain) is generated from Human Liver QuickClone cDNA (Invitrogen) using forward pri...

US Patent US9066954 (2015)


BindingDB Entry DOI: 10.7270/Q2N878JD
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM164469
PNG
(US9066954, 294)
Show SMILES COc1ccc2c(OCc3nnc4ccc(cn34)-c3ccc4NC(=O)Cc4c3)ccnc2c1
Show InChI InChI=1S/C25H19N5O3/c1-32-18-4-5-19-21(12-18)26-9-8-22(19)33-14-24-29-28-23-7-3-16(13-30(23)24)15-2-6-20-17(10-15)11-25(31)27-20/h2-10,12-13H,11,14H2,1H3,(H,27,31)
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 2.80 -49.1n/an/an/an/an/a8.027



Amgen Inc.

US Patent


Assay Description
A PCR product covering residues 1058-1365 of c-Met (c-Met kinase domain) is generated from Human Liver QuickClone cDNA (Invitrogen) using forward pri...

US Patent US9066954 (2015)


BindingDB Entry DOI: 10.7270/Q2N878JD
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM164446
PNG
(US9066954, 141)
Show SMILES COc1ccc2c(OCc3nnc4ccc(nn34)-c3ccc4OCCc4c3)ccnc2c1
Show InChI InChI=1S/C24H19N5O3/c1-30-17-3-4-18-20(13-17)25-10-8-22(18)32-14-24-27-26-23-7-5-19(28-29(23)24)15-2-6-21-16(12-15)9-11-31-21/h2-8,10,12-13H,9,11,14H2,1H3
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 2.90 -49.1n/an/an/an/an/a8.027



Amgen Inc.

US Patent


Assay Description
A PCR product covering residues 1058-1365 of c-Met (c-Met kinase domain) is generated from Human Liver QuickClone cDNA (Invitrogen) using forward pri...

US Patent US9066954 (2015)


BindingDB Entry DOI: 10.7270/Q2N878JD
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM50302905
PNG
(7-methoxy-N-((6-(3-methylisothiazol-5-yl)-[1,2,4]t...)
Show SMILES COc1cnc2c(NCc3nnc4ccc(nn34)-c3cc(C)ns3)ccnc2c1
Show InChI InChI=1S/C19H16N8OS/c1-11-7-16(29-26-11)13-3-4-17-23-24-18(27(17)25-13)10-21-14-5-6-20-15-8-12(28-2)9-22-19(14)15/h3-9H,10H2,1-2H3,(H,20,21)
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US Patent
 3.20 -48.8n/an/an/an/an/a8.027



Amgen Inc.

US Patent


Assay Description
A PCR product covering residues 1058-1365 of c-Met (c-Met kinase domain) is generated from Human Liver QuickClone cDNA (Invitrogen) using forward pri...

US Patent US9066954 (2015)


BindingDB Entry DOI: 10.7270/Q2N878JD
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM164472
PNG
(US9066954, 297)
Show SMILES COc1ccc2c(OCc3nnc4ccc(cn34)-c3cc(C)no3)ccnc2c1
Show InChI InChI=1S/C21H17N5O3/c1-13-9-19(29-25-13)14-3-6-20-23-24-21(26(20)11-14)12-28-18-7-8-22-17-10-15(27-2)4-5-16(17)18/h3-11H,12H2,1-2H3
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 3.20 -48.8n/an/an/an/an/a8.027



Amgen Inc.

US Patent


Assay Description
A PCR product covering residues 1058-1365 of c-Met (c-Met kinase domain) is generated from Human Liver QuickClone cDNA (Invitrogen) using forward pri...

US Patent US9066954 (2015)


BindingDB Entry DOI: 10.7270/Q2N878JD
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM164461
PNG
(US9066954, 226)
Show SMILES COc1ccc2c(OCc3nnc4ccc(nn34)-c3cnc(C)s3)ccnc2c1
Show InChI InChI=1S/C20H16N6O2S/c1-12-22-10-18(29-12)15-5-6-19-23-24-20(26(19)25-15)11-28-17-7-8-21-16-9-13(27-2)3-4-14(16)17/h3-10H,11H2,1-2H3
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 4.70 -47.9n/an/an/an/an/a8.027



Amgen Inc.

US Patent


Assay Description
A PCR product covering residues 1058-1365 of c-Met (c-Met kinase domain) is generated from Human Liver QuickClone cDNA (Invitrogen) using forward pri...

US Patent US9066954 (2015)


BindingDB Entry DOI: 10.7270/Q2N878JD
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM164455
PNG
(US9066954, 187)
Show SMILES COc1cnc2c(NCc3nnc4ccc(nn34)-c3ccc(=O)n(C)c3)ccnc2c1
Show InChI InChI=1S/C21H18N8O2/c1-28-12-13(3-6-20(28)30)15-4-5-18-25-26-19(29(18)27-15)11-23-16-7-8-22-17-9-14(31-2)10-24-21(16)17/h3-10,12H,11H2,1-2H3,(H,22,23)
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US Patent
 4.90 -47.7n/an/an/an/an/a8.027



Amgen Inc.

US Patent


Assay Description
A PCR product covering residues 1058-1365 of c-Met (c-Met kinase domain) is generated from Human Liver QuickClone cDNA (Invitrogen) using forward pri...

US Patent US9066954 (2015)


BindingDB Entry DOI: 10.7270/Q2N878JD
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM164418
PNG
(US9066954, 52)
Show SMILES COc1cnc2c(NCc3nnc4ccc(nn34)-c3ccc4C(=O)N(C)Cc4c3)ccnc2c1
Show InChI InChI=1S/C24H20N8O2/c1-31-13-15-9-14(3-4-17(15)24(31)33)18-5-6-21-28-29-22(32(21)30-18)12-26-19-7-8-25-20-10-16(34-2)11-27-23(19)20/h3-11H,12-13H2,1-2H3,(H,25,26)
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US Patent
 5 -47.7n/an/an/an/an/a8.027



Amgen Inc.

US Patent


Assay Description
A PCR product covering residues 1058-1365 of c-Met (c-Met kinase domain) is generated from Human Liver QuickClone cDNA (Invitrogen) using forward pri...

US Patent US9066954 (2015)


BindingDB Entry DOI: 10.7270/Q2N878JD
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM164445
PNG
(US9066954, 140)
Show SMILES COc1ccc2c(OCc3nnc4ccc(nn34)-c3ccc4N(C)CCOc4c3)ccnc2c1
Show InChI InChI=1S/C25H22N6O3/c1-30-11-12-33-23-13-16(3-7-21(23)30)19-6-8-24-27-28-25(31(24)29-19)15-34-22-9-10-26-20-14-17(32-2)4-5-18(20)22/h3-10,13-14H,11-12,15H2,1-2H3
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 5.20 -47.6n/an/an/an/an/a8.027



Amgen Inc.

US Patent


Assay Description
A PCR product covering residues 1058-1365 of c-Met (c-Met kinase domain) is generated from Human Liver QuickClone cDNA (Invitrogen) using forward pri...

US Patent US9066954 (2015)


BindingDB Entry DOI: 10.7270/Q2N878JD
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM164442
PNG
(US9066954, 121)
Show SMILES FC(F)(c1nnc2ccc(nn12)-c1ccccc1)c1ccc2ncccc2c1
Show InChI InChI=1S/C21H13F2N5/c22-21(23,16-8-9-17-15(13-16)7-4-12-24-17)20-26-25-19-11-10-18(27-28(19)20)14-5-2-1-3-6-14/h1-13H
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 5.40 -47.5n/an/an/an/an/a8.027



Amgen Inc.

US Patent


Assay Description
A PCR product covering residues 1058-1365 of c-Met (c-Met kinase domain) is generated from Human Liver QuickClone cDNA (Invitrogen) using forward pri...

US Patent US9066954 (2015)


BindingDB Entry DOI: 10.7270/Q2N878JD
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM164454
PNG
(US9066954, 186)
Show SMILES COc1ccc2c(OCc3nnc4ccc(nn34)-c3ccc(=O)n(C)c3)ccnc2c1
Show InChI InChI=1S/C22H18N6O3/c1-27-12-14(3-8-22(27)29)17-6-7-20-24-25-21(28(20)26-17)13-31-19-9-10-23-18-11-15(30-2)4-5-16(18)19/h3-12H,13H2,1-2H3
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 6.20 -47.2n/an/an/an/an/a8.027



Amgen Inc.

US Patent


Assay Description
A PCR product covering residues 1058-1365 of c-Met (c-Met kinase domain) is generated from Human Liver QuickClone cDNA (Invitrogen) using forward pri...

US Patent US9066954 (2015)


BindingDB Entry DOI: 10.7270/Q2N878JD
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM164404
PNG
(US9066954, 18)
Show SMILES COc1ccc2c(OCc3nnc4ccc(cn34)-c3cn(C)nn3)ccnc2c1
Show InChI InChI=1S/C20H17N7O2/c1-26-11-17(22-25-26)13-3-6-19-23-24-20(27(19)10-13)12-29-18-7-8-21-16-9-14(28-2)4-5-15(16)18/h3-11H,12H2,1-2H3
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 6.60 -47.0n/an/an/an/an/a8.027



Amgen Inc.

US Patent


Assay Description
A PCR product covering residues 1058-1365 of c-Met (c-Met kinase domain) is generated from Human Liver QuickClone cDNA (Invitrogen) using forward pri...

US Patent US9066954 (2015)


BindingDB Entry DOI: 10.7270/Q2N878JD
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM164463
PNG
(US9066954, 231)
Show SMILES COc1ccc2c(OCc3nnc4ccc(nn34)-c3ccc4C(=O)N(C)Cc4c3)ccnc2c1
Show InChI InChI=1S/C25H20N6O3/c1-30-13-16-11-15(3-5-18(16)25(30)32)20-7-8-23-27-28-24(31(23)29-20)14-34-22-9-10-26-21-12-17(33-2)4-6-19(21)22/h3-12H,13-14H2,1-2H3
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 6.70 -47.0n/an/an/an/an/a8.027



Amgen Inc.

US Patent


Assay Description
A PCR product covering residues 1058-1365 of c-Met (c-Met kinase domain) is generated from Human Liver QuickClone cDNA (Invitrogen) using forward pri...

US Patent US9066954 (2015)


BindingDB Entry DOI: 10.7270/Q2N878JD
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM164419
PNG
(US9066954, 53)
Show SMILES COc1cnc2c(NCc3nnc4ccc(nn34)-c3cnn(c3)C(C)C)ccnc2c1
Show InChI InChI=1S/C21H21N9O/c1-13(2)29-12-14(9-25-29)16-4-5-19-26-27-20(30(19)28-16)11-23-17-6-7-22-18-8-15(31-3)10-24-21(17)18/h4-10,12-13H,11H2,1-3H3,(H,22,23)
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 6.70 -47.0n/an/an/an/an/a8.027



Amgen Inc.

US Patent


Assay Description
A PCR product covering residues 1058-1365 of c-Met (c-Met kinase domain) is generated from Human Liver QuickClone cDNA (Invitrogen) using forward pri...

US Patent US9066954 (2015)


BindingDB Entry DOI: 10.7270/Q2N878JD
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM164476
PNG
(US9066954, 311)
Show SMILES COc1cnc2c(NCc3nnc4ccc(nn34)-c3cnc(C)s3)ccnc2c1
Show InChI InChI=1S/C19H16N8OS/c1-11-21-9-16(29-11)13-3-4-17-24-25-18(27(17)26-13)10-22-14-5-6-20-15-7-12(28-2)8-23-19(14)15/h3-9H,10H2,1-2H3,(H,20,22)
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 7 -46.9n/an/an/an/an/a8.027



Amgen Inc.

US Patent


Assay Description
A PCR product covering residues 1058-1365 of c-Met (c-Met kinase domain) is generated from Human Liver QuickClone cDNA (Invitrogen) using forward pri...

US Patent US9066954 (2015)


BindingDB Entry DOI: 10.7270/Q2N878JD
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM24472
PNG
(4-{[6-(3-fluorophenyl)-[1,2,4]triazolo[4,3-a]pyrid...)
Show SMILES COc1ccc2c(OCc3nnc4ccc(nn34)-c3cccc(F)c3)ccnc2c1
Show InChI InChI=1S/C22H16FN5O2/c1-29-16-5-6-17-19(12-16)24-10-9-20(17)30-13-22-26-25-21-8-7-18(27-28(21)22)14-3-2-4-15(23)11-14/h2-12H,13H2,1H3
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 7 -46.9n/an/an/an/an/a8.027



Amgen Inc.

US Patent


Assay Description
A PCR product covering residues 1058-1365 of c-Met (c-Met kinase domain) is generated from Human Liver QuickClone cDNA (Invitrogen) using forward pri...

US Patent US9066954 (2015)


BindingDB Entry DOI: 10.7270/Q2N878JD
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM164458
PNG
(US9066954, 203)
Show SMILES COc1ccc2c(OCc3nnc4ccc(nn34)-c3ccc4CC(C)(C)Oc4c3)ccnc2c1
Show InChI InChI=1S/C26H23N5O3/c1-26(2)14-17-5-4-16(12-23(17)34-26)20-8-9-24-28-29-25(31(24)30-20)15-33-22-10-11-27-21-13-18(32-3)6-7-19(21)22/h4-13H,14-15H2,1-3H3
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US Patent
 7.5 -46.7n/an/an/an/an/a8.027



Amgen Inc.

US Patent


Assay Description
A PCR product covering residues 1058-1365 of c-Met (c-Met kinase domain) is generated from Human Liver QuickClone cDNA (Invitrogen) using forward pri...

US Patent US9066954 (2015)


BindingDB Entry DOI: 10.7270/Q2N878JD
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM164414
PNG
(US9066954, 40)
Show SMILES COc1cnc2ccc(Cc3nnc4ccc(nn34)-c3ccccc3)cc2c1
Show InChI InChI=1S/C22H17N5O/c1-28-18-13-17-11-15(7-8-19(17)23-14-18)12-22-25-24-21-10-9-20(26-27(21)22)16-5-3-2-4-6-16/h2-11,13-14H,12H2,1H3
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 7.5 -46.7n/an/an/an/an/a8.027



Amgen Inc.

US Patent


Assay Description
A PCR product covering residues 1058-1365 of c-Met (c-Met kinase domain) is generated from Human Liver QuickClone cDNA (Invitrogen) using forward pri...

US Patent US9066954 (2015)


BindingDB Entry DOI: 10.7270/Q2N878JD
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM164438
PNG
(US9066954, 89)
Show SMILES COc1ccc2c(OCc3nnc4ccc(cn34)C(N)=O)ccnc2c1
Show InChI InChI=1S/C18H15N5O3/c1-25-12-3-4-13-14(8-12)20-7-6-15(13)26-10-17-22-21-16-5-2-11(18(19)24)9-23(16)17/h2-9H,10H2,1H3,(H2,19,24)
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 7.90 -46.6n/an/an/an/an/a8.027



Amgen Inc.

US Patent


Assay Description
A PCR product covering residues 1058-1365 of c-Met (c-Met kinase domain) is generated from Human Liver QuickClone cDNA (Invitrogen) using forward pri...

US Patent US9066954 (2015)


BindingDB Entry DOI: 10.7270/Q2N878JD
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM164460
PNG
(US9066954, 209)
Show SMILES COc1ccc2c(OCc3nnc4ccc(nn34)-c3ccncc3)ccnc2c1
Show InChI InChI=1S/C21H16N6O2/c1-28-15-2-3-16-18(12-15)23-11-8-19(16)29-13-21-25-24-20-5-4-17(26-27(20)21)14-6-9-22-10-7-14/h2-12H,13H2,1H3
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 8.90 -46.3n/an/an/an/an/a8.027



Amgen Inc.

US Patent


Assay Description
A PCR product covering residues 1058-1365 of c-Met (c-Met kinase domain) is generated from Human Liver QuickClone cDNA (Invitrogen) using forward pri...

US Patent US9066954 (2015)


BindingDB Entry DOI: 10.7270/Q2N878JD
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM164471
PNG
(US9066954, 296)
Show SMILES COc1cnc2c(NCc3nnc4c(F)cc(cn34)-c3cnc(C)s3)ccnc2c1
Show InChI InChI=1S/C20H16FN7OS/c1-11-23-8-17(30-11)12-5-14(21)20-27-26-18(28(20)10-12)9-24-15-3-4-22-16-6-13(29-2)7-25-19(15)16/h3-8,10H,9H2,1-2H3,(H,22,24)
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 8.90 -46.3n/an/an/an/an/a8.027



Amgen Inc.

US Patent


Assay Description
A PCR product covering residues 1058-1365 of c-Met (c-Met kinase domain) is generated from Human Liver QuickClone cDNA (Invitrogen) using forward pri...

US Patent US9066954 (2015)


BindingDB Entry DOI: 10.7270/Q2N878JD
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM50440890
PNG
(CHEMBL2431841 | US9066954, 341)
Show SMILES Cn1cc(cn1)-c1ccc2nnc(Cc3ccc4ncccc4c3)n2n1
Show InChI InChI=1S/C19H15N7/c1-25-12-15(11-21-25)17-6-7-18-22-23-19(26(18)24-17)10-13-4-5-16-14(9-13)3-2-8-20-16/h2-9,11-12H,10H2,1H3
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 9.10 -46.2n/an/an/an/an/a8.027



Amgen Inc.

US Patent


Assay Description
A PCR product covering residues 1058-1365 of c-Met (c-Met kinase domain) is generated from Human Liver QuickClone cDNA (Invitrogen) using forward pri...

US Patent US9066954 (2015)


BindingDB Entry DOI: 10.7270/Q2N878JD
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM164448
PNG
(US9066954, 148)
Show SMILES C(Oc1ccnc2ccccc12)c1nnc2ccc(nn12)-c1cccs1
Show InChI InChI=1S/C19H13N5OS/c1-2-5-14-13(4-1)16(9-10-20-14)25-12-19-22-21-18-8-7-15(23-24(18)19)17-6-3-11-26-17/h1-11H,12H2
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 9.20 -46.2n/an/an/an/an/a8.027



Amgen Inc.

US Patent


Assay Description
A PCR product covering residues 1058-1365 of c-Met (c-Met kinase domain) is generated from Human Liver QuickClone cDNA (Invitrogen) using forward pri...

US Patent US9066954 (2015)


BindingDB Entry DOI: 10.7270/Q2N878JD
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM164403
PNG
(US9066954, 17)
Show SMILES COc1ccc2c(OCc3nnc4ccc(nn34)-c3ccc(-c4nc(C)no4)c(Cl)c3)ccnc2c1
Show InChI InChI=1S/C25H18ClN7O3/c1-14-28-25(36-32-14)17-5-3-15(11-19(17)26)20-7-8-23-29-30-24(33(23)31-20)13-35-22-9-10-27-21-12-16(34-2)4-6-18(21)22/h3-12H,13H2,1-2H3
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 9.30 -46.1n/an/an/an/an/a8.027



Amgen Inc.

US Patent


Assay Description
A PCR product covering residues 1058-1365 of c-Met (c-Met kinase domain) is generated from Human Liver QuickClone cDNA (Invitrogen) using forward pri...

US Patent US9066954 (2015)


BindingDB Entry DOI: 10.7270/Q2N878JD
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM164467
PNG
(US9066954, 282)
Show SMILES COc1ccc2c(OCc3nnc4ccc(cn34)-c3ccccn3)ccnc2c1
Show InChI InChI=1S/C22H17N5O2/c1-28-16-6-7-17-19(12-16)24-11-9-20(17)29-14-22-26-25-21-8-5-15(13-27(21)22)18-4-2-3-10-23-18/h2-13H,14H2,1H3
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 9.5 -46.1n/an/an/an/an/a8.027



Amgen Inc.

US Patent


Assay Description
A PCR product covering residues 1058-1365 of c-Met (c-Met kinase domain) is generated from Human Liver QuickClone cDNA (Invitrogen) using forward pri...

US Patent US9066954 (2015)


BindingDB Entry DOI: 10.7270/Q2N878JD
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM164493
PNG
(US9066954, 447)
Show SMILES FC(F)(c1noc2ncc(cc12)-c1cc[nH]n1)c1ccc2ncccc2c1
Show InChI InChI=1S/C19H11F2N5O/c20-19(21,13-3-4-15-11(8-13)2-1-6-22-15)17-14-9-12(16-5-7-24-25-16)10-23-18(14)27-26-17/h1-10H,(H,24,25)
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 12.1 -45.5n/an/an/an/an/a8.027



Amgen Inc.

US Patent


Assay Description
A PCR product covering residues 1058-1365 of c-Met (c-Met kinase domain) is generated from Human Liver QuickClone cDNA (Invitrogen) using forward pri...

US Patent US9066954 (2015)


BindingDB Entry DOI: 10.7270/Q2N878JD
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM164416
PNG
(US9066954, 45)
Show SMILES COc1ccc2c(OCc3nnc4ccc(nn34)-c3ccc4nccn4c3)ccnc2c1
Show InChI InChI=1S/C23H17N7O2/c1-31-16-3-4-17-19(12-16)24-9-8-20(17)32-14-23-27-26-22-7-5-18(28-30(22)23)15-2-6-21-25-10-11-29(21)13-15/h2-13H,14H2,1H3
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 12.1 -45.5n/an/an/an/an/a8.027



Amgen Inc.

US Patent


Assay Description
A PCR product covering residues 1058-1365 of c-Met (c-Met kinase domain) is generated from Human Liver QuickClone cDNA (Invitrogen) using forward pri...

US Patent US9066954 (2015)


BindingDB Entry DOI: 10.7270/Q2N878JD
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM164429
PNG
(US9066954, 73)
Show SMILES CNc1ccc(cc1)-c1ccc2nnc(COc3ccnc4cc(OC)ccc34)n2c1
Show InChI InChI=1S/C24H21N5O2/c1-25-18-6-3-16(4-7-18)17-5-10-23-27-28-24(29(23)14-17)15-31-22-11-12-26-21-13-19(30-2)8-9-20(21)22/h3-14,25H,15H2,1-2H3
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US Patent
 12.8 -45.4n/an/an/an/an/a8.027



Amgen Inc.

US Patent


Assay Description
A PCR product covering residues 1058-1365 of c-Met (c-Met kinase domain) is generated from Human Liver QuickClone cDNA (Invitrogen) using forward pri...

US Patent US9066954 (2015)


BindingDB Entry DOI: 10.7270/Q2N878JD
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM164411
PNG
(US9066954, 34)
Show SMILES COc1cnc2c(NCc3nnc4ccc(nn34)-c3cc(C)no3)ccnc2c1
Show InChI InChI=1S/C19H16N8O2/c1-11-7-16(29-26-11)13-3-4-17-23-24-18(27(17)25-13)10-21-14-5-6-20-15-8-12(28-2)9-22-19(14)15/h3-9H,10H2,1-2H3,(H,20,21)
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US Patent
 15.9 -44.8n/an/an/an/an/a8.027



Amgen Inc.

US Patent


Assay Description
A PCR product covering residues 1058-1365 of c-Met (c-Met kinase domain) is generated from Human Liver QuickClone cDNA (Invitrogen) using forward pri...

US Patent US9066954 (2015)


BindingDB Entry DOI: 10.7270/Q2N878JD
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM164409
PNG
(US9066954, 24)
Show SMILES COc1cnc2c(NCc3nnc4ccc(cn34)-c3ccc(F)c(Cl)c3)ccnc2c1
Show InChI InChI=1S/C22H16ClFN6O/c1-31-15-9-19-22(27-10-15)18(6-7-25-19)26-11-21-29-28-20-5-3-14(12-30(20)21)13-2-4-17(24)16(23)8-13/h2-10,12H,11H2,1H3,(H,25,26)
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US Patent
 17.4 -44.6n/an/an/an/an/a8.027



Amgen Inc.

US Patent


Assay Description
A PCR product covering residues 1058-1365 of c-Met (c-Met kinase domain) is generated from Human Liver QuickClone cDNA (Invitrogen) using forward pri...

US Patent US9066954 (2015)


BindingDB Entry DOI: 10.7270/Q2N878JD
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM24484
PNG
(4-{[6-(furan-2-yl)-[1,2,4]triazolo[4,3-a]pyridazin...)
Show SMILES COc1ccc2c(OCc3nnc4ccc(nn34)-c3ccco3)ccnc2c1
Show InChI InChI=1S/C20H15N5O3/c1-26-13-4-5-14-16(11-13)21-9-8-17(14)28-12-20-23-22-19-7-6-15(24-25(19)20)18-3-2-10-27-18/h2-11H,12H2,1H3
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 17.6 -44.6n/an/an/an/an/a8.027



Amgen Inc.

US Patent


Assay Description
A PCR product covering residues 1058-1365 of c-Met (c-Met kinase domain) is generated from Human Liver QuickClone cDNA (Invitrogen) using forward pri...

US Patent US9066954 (2015)


BindingDB Entry DOI: 10.7270/Q2N878JD
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM164439
PNG
(US9066954, 91)
Show SMILES COc1ccc2c(OCc3nnc4ccc(cn34)C(O)=O)ccnc2c1
Show InChI InChI=1S/C18H14N4O4/c1-25-12-3-4-13-14(8-12)19-7-6-15(13)26-10-17-21-20-16-5-2-11(18(23)24)9-22(16)17/h2-9H,10H2,1H3,(H,23,24)
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 19.2 -44.3n/an/an/an/an/a8.027



Amgen Inc.

US Patent


Assay Description
A PCR product covering residues 1058-1365 of c-Met (c-Met kinase domain) is generated from Human Liver QuickClone cDNA (Invitrogen) using forward pri...

US Patent US9066954 (2015)


BindingDB Entry DOI: 10.7270/Q2N878JD
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM164465
PNG
(US9066954, 279)
Show SMILES COc1ccc2c(OCc3nnc4ccc(cn34)-c3ncc(C)s3)ccnc2c1
Show InChI InChI=1S/C21H17N5O2S/c1-13-10-23-21(29-13)14-3-6-19-24-25-20(26(19)11-14)12-28-18-7-8-22-17-9-15(27-2)4-5-16(17)18/h3-11H,12H2,1-2H3
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 19.7 -44.3n/an/an/an/an/a8.027



Amgen Inc.

US Patent


Assay Description
A PCR product covering residues 1058-1365 of c-Met (c-Met kinase domain) is generated from Human Liver QuickClone cDNA (Invitrogen) using forward pri...

US Patent US9066954 (2015)


BindingDB Entry DOI: 10.7270/Q2N878JD
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM164428
PNG
(US9066954, 70)
Show SMILES O=c1[nH]cnc2ccc(Cc3nnc4ccc(nn34)-c3ccccc3)cc12
Show InChI InChI=1S/C20H14N6O/c27-20-15-10-13(6-7-17(15)21-12-22-20)11-19-24-23-18-9-8-16(25-26(18)19)14-4-2-1-3-5-14/h1-10,12H,11H2,(H,21,22,27)
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 22.9 -43.9n/an/an/an/an/a8.027



Amgen Inc.

US Patent


Assay Description
A PCR product covering residues 1058-1365 of c-Met (c-Met kinase domain) is generated from Human Liver QuickClone cDNA (Invitrogen) using forward pri...

US Patent US9066954 (2015)


BindingDB Entry DOI: 10.7270/Q2N878JD
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM164459
PNG
(US9066954, 208)
Show SMILES COc1ccc2c(OCc3nnc4ccc(nn34)-c3ccc[nH]3)ccnc2c1
Show InChI InChI=1S/C20H16N6O2/c1-27-13-4-5-14-17(11-13)22-10-8-18(14)28-12-20-24-23-19-7-6-16(25-26(19)20)15-3-2-9-21-15/h2-11,21H,12H2,1H3
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 23.7 -43.8n/an/an/an/an/a8.027



Amgen Inc.

US Patent


Assay Description
A PCR product covering residues 1058-1365 of c-Met (c-Met kinase domain) is generated from Human Liver QuickClone cDNA (Invitrogen) using forward pri...

US Patent US9066954 (2015)


BindingDB Entry DOI: 10.7270/Q2N878JD
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM164417
PNG
(US9066954, 50)
Show SMILES COc1ccc2c(OCc3nnc4ccc(nn34)C#CC(C)(C)O)ccnc2c1
Show InChI InChI=1S/C21H19N5O3/c1-21(2,27)10-8-14-4-7-19-23-24-20(26(19)25-14)13-29-18-9-11-22-17-12-15(28-3)5-6-16(17)18/h4-7,9,11-12,27H,13H2,1-3H3
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 23.8 -43.8n/an/an/an/an/a8.027



Amgen Inc.

US Patent


Assay Description
A PCR product covering residues 1058-1365 of c-Met (c-Met kinase domain) is generated from Human Liver QuickClone cDNA (Invitrogen) using forward pri...

US Patent US9066954 (2015)


BindingDB Entry DOI: 10.7270/Q2N878JD
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM164433
PNG
(US9066954, 84)
Show SMILES COc1cnc2c(NCc3nnc4ccc(nn34)-c3cnn[nH]3)ccnc2c1
Show InChI InChI=1S/C17H14N10O/c1-28-10-6-13-17(20-7-10)12(4-5-18-13)19-9-16-24-23-15-3-2-11(25-27(15)16)14-8-21-26-22-14/h2-8H,9H2,1H3,(H,18,19)(H,21,22,26)
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 26.1 -43.6n/an/an/an/an/a8.027



Amgen Inc.

US Patent


Assay Description
A PCR product covering residues 1058-1365 of c-Met (c-Met kinase domain) is generated from Human Liver QuickClone cDNA (Invitrogen) using forward pri...

US Patent US9066954 (2015)


BindingDB Entry DOI: 10.7270/Q2N878JD
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM164470
PNG
(US9066954, 295)
Show SMILES COc1cnc2c(NCc3nnc4c(F)cc(cn34)-c3cc(C)ns3)ccnc2c1
Show InChI InChI=1S/C20H16FN7OS/c1-11-5-17(30-27-11)12-6-14(21)20-26-25-18(28(20)10-12)9-23-15-3-4-22-16-7-13(29-2)8-24-19(15)16/h3-8,10H,9H2,1-2H3,(H,22,23)
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 26.9 -43.5n/an/an/an/an/a8.027



Amgen Inc.

US Patent


Assay Description
A PCR product covering residues 1058-1365 of c-Met (c-Met kinase domain) is generated from Human Liver QuickClone cDNA (Invitrogen) using forward pri...

US Patent US9066954 (2015)


BindingDB Entry DOI: 10.7270/Q2N878JD
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM164443
PNG
(US9066954, 122)
Show SMILES Nc1ncnc2ccc(Cc3nnc4ccc(nn34)-c3ccccc3)cc12
Show InChI InChI=1S/C20H15N7/c21-20-15-10-13(6-7-17(15)22-12-23-20)11-19-25-24-18-9-8-16(26-27(18)19)14-4-2-1-3-5-14/h1-10,12H,11H2,(H2,21,22,23)
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 27.2 -43.5n/an/an/an/an/a8.027



Amgen Inc.

US Patent


Assay Description
A PCR product covering residues 1058-1365 of c-Met (c-Met kinase domain) is generated from Human Liver QuickClone cDNA (Invitrogen) using forward pri...

US Patent US9066954 (2015)


BindingDB Entry DOI: 10.7270/Q2N878JD
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM164498
PNG
(US9066954, 441)
Show SMILES C[C@@H](c1noc2ncc(cc12)-c1cnn(C)c1)c1ccc2ncccc2c1 |r|
Show InChI InChI=1S/C21H17N5O/c1-13(14-5-6-19-15(8-14)4-3-7-22-19)20-18-9-16(10-23-21(18)27-25-20)17-11-24-26(2)12-17/h3-13H,1-2H3/t13-/m1/s1
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 28.6 -43.3n/an/an/an/an/a8.027



Amgen Inc.

US Patent


Assay Description
A PCR product covering residues 1058-1365 of c-Met (c-Met kinase domain) is generated from Human Liver QuickClone cDNA (Invitrogen) using forward pri...

US Patent US9066954 (2015)


BindingDB Entry DOI: 10.7270/Q2N878JD
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM164456
PNG
(US9066954, 199)
Show SMILES COc1ccc2c(OCc3nnc4ccc(nn34)-c3ccc(cc3)S(=O)(=O)N(C)C)ccnc2c1
Show InChI InChI=1S/C24H22N6O4S/c1-29(2)35(31,32)18-7-4-16(5-8-18)20-10-11-23-26-27-24(30(23)28-20)15-34-22-12-13-25-21-14-17(33-3)6-9-19(21)22/h4-14H,15H2,1-3H3
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 34.5 -42.9n/an/an/an/an/a8.027



Amgen Inc.

US Patent


Assay Description
A PCR product covering residues 1058-1365 of c-Met (c-Met kinase domain) is generated from Human Liver QuickClone cDNA (Invitrogen) using forward pri...

US Patent US9066954 (2015)


BindingDB Entry DOI: 10.7270/Q2N878JD
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM164491
PNG
(US9066954, 437)
Show SMILES Fc1cc(cn2c(Cc3ccc4ncccc4c3)nnc12)-c1ccccc1
Show InChI InChI=1S/C22H15FN4/c23-19-13-18(16-5-2-1-3-6-16)14-27-21(25-26-22(19)27)12-15-8-9-20-17(11-15)7-4-10-24-20/h1-11,13-14H,12H2
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 36.4 -42.7n/an/an/an/an/a8.027



Amgen Inc.

US Patent


Assay Description
A PCR product covering residues 1058-1365 of c-Met (c-Met kinase domain) is generated from Human Liver QuickClone cDNA (Invitrogen) using forward pri...

US Patent US9066954 (2015)


BindingDB Entry DOI: 10.7270/Q2N878JD
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM164412
PNG
(US9066954, 38)
Show SMILES COc1ccc2c(OCc3nnc4ccc(cn34)-c3cccc(=O)[nH]3)ccnc2c1
Show InChI InChI=1S/C22H17N5O3/c1-29-15-6-7-16-18(11-15)23-10-9-19(16)30-13-21-26-25-20-8-5-14(12-27(20)21)17-3-2-4-22(28)24-17/h2-12H,13H2,1H3,(H,24,28)
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 37 -42.7n/an/an/an/an/a8.027



Amgen Inc.

US Patent


Assay Description
A PCR product covering residues 1058-1365 of c-Met (c-Met kinase domain) is generated from Human Liver QuickClone cDNA (Invitrogen) using forward pri...

US Patent US9066954 (2015)


BindingDB Entry DOI: 10.7270/Q2N878JD
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM164462
PNG
(US9066954, 229)
Show SMILES COc1ccc2c(OCc3nnc4ccc(nn34)-c3cnn(c3)C3CCN(CC3)C(=O)OC(C)(C)C)ccnc2c1
Show InChI InChI=1S/C29H32N8O4/c1-29(2,3)41-28(38)35-13-10-20(11-14-35)36-17-19(16-31-36)23-7-8-26-32-33-27(37(26)34-23)18-40-25-9-12-30-24-15-21(39-4)5-6-22(24)25/h5-9,12,15-17,20H,10-11,13-14,18H2,1-4H3
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 40.2 -42.5n/an/an/an/an/a8.027



Amgen Inc.

US Patent


Assay Description
A PCR product covering residues 1058-1365 of c-Met (c-Met kinase domain) is generated from Human Liver QuickClone cDNA (Invitrogen) using forward pri...

US Patent US9066954 (2015)


BindingDB Entry DOI: 10.7270/Q2N878JD
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM164474
PNG
(US9066954, 306)
Show SMILES Brc1ccc2nnc(Cc3ccc4ncccc4c3)n2c1
Show InChI InChI=1S/C16H11BrN4/c17-13-4-6-15-19-20-16(21(15)10-13)9-11-3-5-14-12(8-11)2-1-7-18-14/h1-8,10H,9H2
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 49 -42.0n/an/an/an/an/a8.027



Amgen Inc.

US Patent


Assay Description
A PCR product covering residues 1058-1365 of c-Met (c-Met kinase domain) is generated from Human Liver QuickClone cDNA (Invitrogen) using forward pri...

US Patent US9066954 (2015)


BindingDB Entry DOI: 10.7270/Q2N878JD
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM164450
PNG
(US9066954, 154)
Show SMILES COc1ccc2c(OCc3nnc4ccc(nn34)-c3cncnc3)ccnc2c1
Show InChI InChI=1S/C20H15N7O2/c1-28-14-2-3-15-17(8-14)23-7-6-18(15)29-11-20-25-24-19-5-4-16(26-27(19)20)13-9-21-12-22-10-13/h2-10,12H,11H2,1H3
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 50.2 -41.9n/an/an/an/an/a8.027



Amgen Inc.

US Patent


Assay Description
A PCR product covering residues 1058-1365 of c-Met (c-Met kinase domain) is generated from Human Liver QuickClone cDNA (Invitrogen) using forward pri...

US Patent US9066954 (2015)


BindingDB Entry DOI: 10.7270/Q2N878JD
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM164413
PNG
(US9066954, 39)
Show SMILES Clc1ccc2nnc(Cc3ccc4ncccc4c3)n2n1
Show InChI InChI=1S/C15H10ClN5/c16-13-5-6-14-18-19-15(21(14)20-13)9-10-3-4-12-11(8-10)2-1-7-17-12/h1-8H,9H2
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 50.5 -41.9n/an/an/an/an/a8.027



Amgen Inc.

US Patent


Assay Description
A PCR product covering residues 1058-1365 of c-Met (c-Met kinase domain) is generated from Human Liver QuickClone cDNA (Invitrogen) using forward pri...

US Patent US9066954 (2015)


BindingDB Entry DOI: 10.7270/Q2N878JD
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM164452
PNG
(US9066954, 170)
Show SMILES COc1cnc2c(NC3(CC3)c3nnc4ccc(nn34)-c3ccccc3)ccnc2c1
Show InChI InChI=1S/C23H19N7O/c1-31-16-13-19-21(25-14-16)18(9-12-24-19)26-23(10-11-23)22-28-27-20-8-7-17(29-30(20)22)15-5-3-2-4-6-15/h2-9,12-14H,10-11H2,1H3,(H,24,26)
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 50.8 -41.9n/an/an/an/an/a8.027



Amgen Inc.

US Patent


Assay Description
A PCR product covering residues 1058-1365 of c-Met (c-Met kinase domain) is generated from Human Liver QuickClone cDNA (Invitrogen) using forward pri...

US Patent US9066954 (2015)


BindingDB Entry DOI: 10.7270/Q2N878JD
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM164468
PNG
(US9066954, 283)
Show SMILES COc1ccc2c(OCc3nnc4ccc(cn34)-c3ccc[nH]3)ccnc2c1
Show InChI InChI=1S/C21H17N5O2/c1-27-15-5-6-16-18(11-15)23-10-8-19(16)28-13-21-25-24-20-7-4-14(12-26(20)21)17-3-2-9-22-17/h2-12,22H,13H2,1H3
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US Patent
 52.6 -41.8n/an/an/an/an/a8.027



Amgen Inc.

US Patent


Assay Description
A PCR product covering residues 1058-1365 of c-Met (c-Met kinase domain) is generated from Human Liver QuickClone cDNA (Invitrogen) using forward pri...

US Patent US9066954 (2015)


BindingDB Entry DOI: 10.7270/Q2N878JD
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM164466
PNG
(US9066954, 281)
Show SMILES COc1ccc2c(OCc3nnc4ccc(cn34)-c3ccnnc3)ccnc2c1
Show InChI InChI=1S/C21H16N6O2/c1-28-16-3-4-17-18(10-16)22-8-7-19(17)29-13-21-26-25-20-5-2-15(12-27(20)21)14-6-9-23-24-11-14/h2-12H,13H2,1H3
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 63.1 -41.4n/an/an/an/an/a8.027



Amgen Inc.

US Patent


Assay Description
A PCR product covering residues 1058-1365 of c-Met (c-Met kinase domain) is generated from Human Liver QuickClone cDNA (Invitrogen) using forward pri...

US Patent US9066954 (2015)


BindingDB Entry DOI: 10.7270/Q2N878JD
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM164410
PNG
(US9066954, 33)
Show SMILES COc1cnc2c(NCc3nnc4ccc(nn34)C#C)ccnc2c1
Show InChI InChI=1S/C17H13N7O/c1-3-11-4-5-15-21-22-16(24(15)23-11)10-19-13-6-7-18-14-8-12(25-2)9-20-17(13)14/h1,4-9H,10H2,2H3,(H,18,19)
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 73.2 -41.0n/an/an/an/an/a8.027



Amgen Inc.

US Patent


Assay Description
A PCR product covering residues 1058-1365 of c-Met (c-Met kinase domain) is generated from Human Liver QuickClone cDNA (Invitrogen) using forward pri...

US Patent US9066954 (2015)


BindingDB Entry DOI: 10.7270/Q2N878JD
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM164451
PNG
(US9066954, 167)
Show SMILES COc1cnc2c(N[C@@H](C)c3nnc4ccc(nn34)-c3ccccc3)ccnc2c1 |r|
Show InChI InChI=1S/C22H19N7O/c1-14(25-18-10-11-23-19-12-16(30-2)13-24-21(18)19)22-27-26-20-9-8-17(28-29(20)22)15-6-4-3-5-7-15/h3-14H,1-2H3,(H,23,25)/t14-/m0/s1
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 73.3 -41.0n/an/an/an/an/a8.027



Amgen Inc.

US Patent


Assay Description
A PCR product covering residues 1058-1365 of c-Met (c-Met kinase domain) is generated from Human Liver QuickClone cDNA (Invitrogen) using forward pri...

US Patent US9066954 (2015)


BindingDB Entry DOI: 10.7270/Q2N878JD
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM164431
PNG
(US9066954, 79)
Show SMILES C[C@@H](c1nnc2ccc(nn12)-c1ccccc1)c1ccc2ncccc2c1 |r|
Show InChI InChI=1S/C22H17N5/c1-15(17-9-10-19-18(14-17)8-5-13-23-19)22-25-24-21-12-11-20(26-27(21)22)16-6-3-2-4-7-16/h2-15H,1H3/t15-/m1/s1
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 83.4 -40.7n/an/an/an/an/a8.027



Amgen Inc.

US Patent


Assay Description
A PCR product covering residues 1058-1365 of c-Met (c-Met kinase domain) is generated from Human Liver QuickClone cDNA (Invitrogen) using forward pri...

US Patent US9066954 (2015)


BindingDB Entry DOI: 10.7270/Q2N878JD
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM164422
PNG
(US9066954, 59)
Show SMILES COc1ccc2c(OCc3nnc4ccc(nn34)-c3cnn(c3)C3CCNCC3)ccnc2c1
Show InChI InChI=1S/C24H24N8O2/c1-33-18-2-3-19-21(12-18)26-11-8-22(19)34-15-24-29-28-23-5-4-20(30-32(23)24)16-13-27-31(14-16)17-6-9-25-10-7-17/h2-5,8,11-14,17,25H,6-7,9-10,15H2,1H3
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 84.5 -40.6n/an/an/an/an/a8.027



Amgen Inc.

US Patent


Assay Description
A PCR product covering residues 1058-1365 of c-Met (c-Met kinase domain) is generated from Human Liver QuickClone cDNA (Invitrogen) using forward pri...

US Patent US9066954 (2015)


BindingDB Entry DOI: 10.7270/Q2N878JD
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM164484
PNG
(US9066954, 333)
Show SMILES C(c1nnc2ccc(nn12)-c1ccccc1)c1ccc2nccnc2c1
Show InChI InChI=1S/C20H14N6/c1-2-4-15(5-3-1)16-8-9-19-23-24-20(26(19)25-16)13-14-6-7-17-18(12-14)22-11-10-21-17/h1-12H,13H2
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US Patent
 107 -40.1n/an/an/an/an/a8.027



Amgen Inc.

US Patent


Assay Description
A PCR product covering residues 1058-1365 of c-Met (c-Met kinase domain) is generated from Human Liver QuickClone cDNA (Invitrogen) using forward pri...

US Patent US9066954 (2015)


BindingDB Entry DOI: 10.7270/Q2N878JD
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM164444
PNG
(US9066954, 134)
Show SMILES NC(=O)c1cc2nccc(OCc3nnc4ccc(nn34)-c3ccccc3)c2s1
Show InChI InChI=1S/C20H14N6O2S/c21-20(27)16-10-14-19(29-16)15(8-9-22-14)28-11-18-24-23-17-7-6-13(25-26(17)18)12-4-2-1-3-5-12/h1-10H,11H2,(H2,21,27)
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 116 -39.8n/an/an/an/an/a8.027



Amgen Inc.

US Patent


Assay Description
A PCR product covering residues 1058-1365 of c-Met (c-Met kinase domain) is generated from Human Liver QuickClone cDNA (Invitrogen) using forward pri...

US Patent US9066954 (2015)


BindingDB Entry DOI: 10.7270/Q2N878JD
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM164408
PNG
(US9066954, 23)
Show SMILES COc1ccc2c(OCc3nnn4ccc(cc34)-c3ccccc3)ccnc2c1
Show InChI InChI=1S/C23H18N4O2/c1-28-18-7-8-19-20(14-18)24-11-9-23(19)29-15-21-22-13-17(10-12-27(22)26-25-21)16-5-3-2-4-6-16/h2-14H,15H2,1H3
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 133 -39.5n/an/an/an/an/a8.027



Amgen Inc.

US Patent


Assay Description
A PCR product covering residues 1058-1365 of c-Met (c-Met kinase domain) is generated from Human Liver QuickClone cDNA (Invitrogen) using forward pri...

US Patent US9066954 (2015)


BindingDB Entry DOI: 10.7270/Q2N878JD
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM50302897
PNG
((S)-7-methoxy-4-(1-(6-phenyl-[1,2,4]triazolo[4,3-b...)
Show SMILES COc1ccc2c(O[C@@H](C)c3nnc4ccc(nn34)-c3ccccc3)ccnc2c1 |r|
Show InChI InChI=1S/C23H19N5O2/c1-15(30-21-12-13-24-20-14-17(29-2)8-9-18(20)21)23-26-25-22-11-10-19(27-28(22)23)16-6-4-3-5-7-16/h3-15H,1-2H3/t15-/m0/s1
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 141 -39.4n/an/an/an/an/a8.027



Amgen Inc.

US Patent


Assay Description
A PCR product covering residues 1058-1365 of c-Met (c-Met kinase domain) is generated from Human Liver QuickClone cDNA (Invitrogen) using forward pri...

US Patent US9066954 (2015)


BindingDB Entry DOI: 10.7270/Q2N878JD
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM164437
PNG
(US9066954, 88)
Show SMILES COc1ccc2c(OCc3nnc4ccc(cn34)[N+]#[C-])ccnc2c1
Show InChI InChI=1S/C18H13N5O2/c1-19-12-3-6-17-21-22-18(23(17)10-12)11-25-16-7-8-20-15-9-13(24-2)4-5-14(15)16/h3-10H,11H2,2H3
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 152 -39.2n/an/an/an/an/a8.027



Amgen Inc.

US Patent


Assay Description
A PCR product covering residues 1058-1365 of c-Met (c-Met kinase domain) is generated from Human Liver QuickClone cDNA (Invitrogen) using forward pri...

US Patent US9066954 (2015)


BindingDB Entry DOI: 10.7270/Q2N878JD
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM164447
PNG
(US9066954, 144)
Show SMILES COc1cc2ncnc(OCc3nnc4ccc(nn34)-c3ccccc3)c2cc1OC
Show InChI InChI=1S/C22H18N6O3/c1-29-18-10-15-17(11-19(18)30-2)23-13-24-22(15)31-12-21-26-25-20-9-8-16(27-28(20)21)14-6-4-3-5-7-14/h3-11,13H,12H2,1-2H3
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 169 -38.9n/an/an/an/an/a8.027



Amgen Inc.

US Patent


Assay Description
A PCR product covering residues 1058-1365 of c-Met (c-Met kinase domain) is generated from Human Liver QuickClone cDNA (Invitrogen) using forward pri...

US Patent US9066954 (2015)


BindingDB Entry DOI: 10.7270/Q2N878JD
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM164497
PNG
(US9066954, 440)
Show SMILES Cn1cc(cn1)-c1cnc2onc(c2c1)C(F)(F)c1ccc2ncccc2c1
Show InChI InChI=1S/C20H13F2N5O/c1-27-11-14(10-25-27)13-8-16-18(26-28-19(16)24-9-13)20(21,22)15-4-5-17-12(7-15)3-2-6-23-17/h2-11H,1H3
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 172 -38.9n/an/an/an/an/a8.027



Amgen Inc.

US Patent


Assay Description
A PCR product covering residues 1058-1365 of c-Met (c-Met kinase domain) is generated from Human Liver QuickClone cDNA (Invitrogen) using forward pri...

US Patent US9066954 (2015)


BindingDB Entry DOI: 10.7270/Q2N878JD
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM164494
PNG
(US9066954, 450)
Show SMILES Fc1cc(F)cc(c1)-c1ccc2onc(c2n1)C(F)(F)c1ccc2ncccc2c1
Show InChI InChI=1S/C22H11F4N3O/c23-15-9-13(10-16(24)11-15)18-5-6-19-20(28-18)21(29-30-19)22(25,26)14-3-4-17-12(8-14)2-1-7-27-17/h1-11H
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 182 -38.7n/an/an/an/an/a8.027



Amgen Inc.

US Patent


Assay Description
A PCR product covering residues 1058-1365 of c-Met (c-Met kinase domain) is generated from Human Liver QuickClone cDNA (Invitrogen) using forward pri...

US Patent US9066954 (2015)


BindingDB Entry DOI: 10.7270/Q2N878JD
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM164478
PNG
(US9066954, 315)
Show SMILES C(c1nnc2ccc(nn12)-c1ccccc1)c1cccc2cnccc12
Show InChI InChI=1S/C21H15N5/c1-2-5-15(6-3-1)19-9-10-20-23-24-21(26(20)25-19)13-16-7-4-8-17-14-22-12-11-18(16)17/h1-12,14H,13H2
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 220 -38.3n/an/an/an/an/a8.027



Amgen Inc.

US Patent


Assay Description
A PCR product covering residues 1058-1365 of c-Met (c-Met kinase domain) is generated from Human Liver QuickClone cDNA (Invitrogen) using forward pri...

US Patent US9066954 (2015)


BindingDB Entry DOI: 10.7270/Q2N878JD
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM164481
PNG
(US9066954, 321)
Show SMILES Oc1ccc(Cc2nnc3ccc(nn23)-c2ccc[nH]2)cc1
Show InChI InChI=1S/C16H13N5O/c22-12-5-3-11(4-6-12)10-16-19-18-15-8-7-14(20-21(15)16)13-2-1-9-17-13/h1-9,17,22H,10H2
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 241 -38.0n/an/an/an/an/a8.027



Amgen Inc.

US Patent


Assay Description
A PCR product covering residues 1058-1365 of c-Met (c-Met kinase domain) is generated from Human Liver QuickClone cDNA (Invitrogen) using forward pri...

US Patent US9066954 (2015)


BindingDB Entry DOI: 10.7270/Q2N878JD
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM164492
PNG
(US9066954, 439)
Show SMILES Fc1cc(F)cc(c1)-c1cnc2onc(c2c1)C(F)(F)c1ccc2ncccc2c1
Show InChI InChI=1S/C22H11F4N3O/c23-16-7-13(8-17(24)10-16)14-9-18-20(29-30-21(18)28-11-14)22(25,26)15-3-4-19-12(6-15)2-1-5-27-19/h1-11H
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 253 -37.9n/an/an/an/an/a8.027



Amgen Inc.

US Patent


Assay Description
A PCR product covering residues 1058-1365 of c-Met (c-Met kinase domain) is generated from Human Liver QuickClone cDNA (Invitrogen) using forward pri...

US Patent US9066954 (2015)


BindingDB Entry DOI: 10.7270/Q2N878JD
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM164432
PNG
(US9066954, 82)
Show SMILES O[C@H](c1nnc2ccc(nn12)-c1ccccc1)c1ccc2ncccc2c1 |r|
Show InChI InChI=1S/C21H15N5O/c27-20(16-8-9-17-15(13-16)7-4-12-22-17)21-24-23-19-11-10-18(25-26(19)21)14-5-2-1-3-6-14/h1-13,20,27H/t20-/m0/s1
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 262 -37.8n/an/an/an/an/a8.027



Amgen Inc.

US Patent


Assay Description
A PCR product covering residues 1058-1365 of c-Met (c-Met kinase domain) is generated from Human Liver QuickClone cDNA (Invitrogen) using forward pri...

US Patent US9066954 (2015)


BindingDB Entry DOI: 10.7270/Q2N878JD
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM164490
PNG
(US9066954, 430)
Show SMILES CC(O)(c1cnc2ccc(nn12)-c1ccccc1)c1ccc2ncccc2c1
Show InChI InChI=1S/C23H18N4O/c1-23(28,18-9-10-19-17(14-18)8-5-13-24-19)21-15-25-22-12-11-20(26-27(21)22)16-6-3-2-4-7-16/h2-15,28H,1H3
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 348 -37.1n/an/an/an/an/a8.027



Amgen Inc.

US Patent


Assay Description
A PCR product covering residues 1058-1365 of c-Met (c-Met kinase domain) is generated from Human Liver QuickClone cDNA (Invitrogen) using forward pri...

US Patent US9066954 (2015)


BindingDB Entry DOI: 10.7270/Q2N878JD
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM164427
PNG
(US9066954, 69)
Show SMILES Oc1ccc(Cc2nnc3ccc(cn23)-c2ccc[nH]2)cc1
Show InChI InChI=1S/C17H14N4O/c22-14-6-3-12(4-7-14)10-17-20-19-16-8-5-13(11-21(16)17)15-2-1-9-18-15/h1-9,11,18,22H,10H2
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 375 -36.9n/an/an/an/an/a8.027



Amgen Inc.

US Patent


Assay Description
A PCR product covering residues 1058-1365 of c-Met (c-Met kinase domain) is generated from Human Liver QuickClone cDNA (Invitrogen) using forward pri...

US Patent US9066954 (2015)


BindingDB Entry DOI: 10.7270/Q2N878JD
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM164489
PNG
(US9066954, 376)
Show SMILES Cc1cc(sn1)-c1ccc2nnc(CNc3ccnc4cc(OCCn5cccn5)cnc34)n2n1
Show InChI InChI=1S/C23H20N10OS/c1-15-11-20(35-31-15)17-3-4-21-28-29-22(33(21)30-17)14-25-18-5-7-24-19-12-16(13-26-23(18)19)34-10-9-32-8-2-6-27-32/h2-8,11-13H,9-10,14H2,1H3,(H,24,25)
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 394 -36.8n/an/an/an/an/a8.027



Amgen Inc.

US Patent


Assay Description
A PCR product covering residues 1058-1365 of c-Met (c-Met kinase domain) is generated from Human Liver QuickClone cDNA (Invitrogen) using forward pri...

US Patent US9066954 (2015)


BindingDB Entry DOI: 10.7270/Q2N878JD
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM164423
PNG
(US9066954, 61)
Show SMILES C(Nc1ccnc(Nc2ccccc2)n1)c1nnc2ccc(nn12)-c1ccccc1
Show InChI InChI=1S/C22H18N8/c1-3-7-16(8-4-1)18-11-12-20-27-28-21(30(20)29-18)15-24-19-13-14-23-22(26-19)25-17-9-5-2-6-10-17/h1-14H,15H2,(H2,23,24,25,26)
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 399 -36.8n/an/an/an/an/a8.027



Amgen Inc.

US Patent


Assay Description
A PCR product covering residues 1058-1365 of c-Met (c-Met kinase domain) is generated from Human Liver QuickClone cDNA (Invitrogen) using forward pri...

US Patent US9066954 (2015)


BindingDB Entry DOI: 10.7270/Q2N878JD
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM164496
PNG
(US9066954, 3)
Show SMILES O=C(Nc1cc(OCc2nnc3ccc(nn23)-c2ccccc2)ccn1)N1CCCC1
Show InChI InChI=1S/C22H21N7O2/c30-22(28-12-4-5-13-28)24-19-14-17(10-11-23-19)31-15-21-26-25-20-9-8-18(27-29(20)21)16-6-2-1-3-7-16/h1-3,6-11,14H,4-5,12-13,15H2,(H,23,24,30)
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US Patent
 400 -36.8n/an/an/an/an/a8.027



Amgen Inc.

US Patent


Assay Description
A PCR product covering residues 1058-1365 of c-Met (c-Met kinase domain) is generated from Human Liver QuickClone cDNA (Invitrogen) using forward pri...

US Patent US9066954 (2015)


BindingDB Entry DOI: 10.7270/Q2N878JD
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM164485
PNG
(US9066954, 334)
Show SMILES Nc1ncc2cc(Cc3nnc4ccc(nn34)-c3ccccc3)ccc2n1
Show InChI InChI=1S/C20H15N7/c21-20-22-12-15-10-13(6-7-16(15)23-20)11-19-25-24-18-9-8-17(26-27(18)19)14-4-2-1-3-5-14/h1-10,12H,11H2,(H2,21,22,23)
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US Patent
 416 -36.7n/an/an/an/an/a8.027



Amgen Inc.

US Patent


Assay Description
A PCR product covering residues 1058-1365 of c-Met (c-Met kinase domain) is generated from Human Liver QuickClone cDNA (Invitrogen) using forward pri...

US Patent US9066954 (2015)


BindingDB Entry DOI: 10.7270/Q2N878JD
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM164449
PNG
(US9066954, 152)
Show SMILES COc1cc2nccc(OCc3nnc4ccc(nn34)-c3ccccc3)c2cn1
Show InChI InChI=1S/C21H16N6O2/c1-28-21-11-17-15(12-23-21)18(9-10-22-17)29-13-20-25-24-19-8-7-16(26-27(19)20)14-5-3-2-4-6-14/h2-12H,13H2,1H3
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 484 -36.3n/an/an/an/an/a8.027



Amgen Inc.

US Patent


Assay Description
A PCR product covering residues 1058-1365 of c-Met (c-Met kinase domain) is generated from Human Liver QuickClone cDNA (Invitrogen) using forward pri...

US Patent US9066954 (2015)


BindingDB Entry DOI: 10.7270/Q2N878JD
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM164406
PNG
(US9066954, 20)
Show SMILES COc1ccc2c(OCc3nnc4ccc(nn34)C#CCN(C)C)ccnc2c1
Show InChI InChI=1S/C21H20N6O2/c1-26(2)12-4-5-15-6-9-20-23-24-21(27(20)25-15)14-29-19-10-11-22-18-13-16(28-3)7-8-17(18)19/h6-11,13H,12,14H2,1-3H3
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 556 -35.9n/an/an/an/an/a8.027



Amgen Inc.

US Patent


Assay Description
A PCR product covering residues 1058-1365 of c-Met (c-Met kinase domain) is generated from Human Liver QuickClone cDNA (Invitrogen) using forward pri...

US Patent US9066954 (2015)


BindingDB Entry DOI: 10.7270/Q2N878JD
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM164426
PNG
(US9066954, 68)
Show SMILES Oc1ccc(Cc2nnc3ccc(cn23)-c2cnccn2)cc1
Show InChI InChI=1S/C17H13N5O/c23-14-4-1-12(2-5-14)9-17-21-20-16-6-3-13(11-22(16)17)15-10-18-7-8-19-15/h1-8,10-11,23H,9H2
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 556 -35.9n/an/an/an/an/a8.027



Amgen Inc.

US Patent


Assay Description
A PCR product covering residues 1058-1365 of c-Met (c-Met kinase domain) is generated from Human Liver QuickClone cDNA (Invitrogen) using forward pri...

US Patent US9066954 (2015)


BindingDB Entry DOI: 10.7270/Q2N878JD
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM164499
PNG
(US9066954, 466)
Show SMILES COc1cnc2c(NCc3coc4ccc(nc34)-c3cc(F)cc(F)c3)ccnc2c1
Show InChI InChI=1S/C23H16F2N4O2/c1-30-17-9-20-23(28-11-17)19(4-5-26-20)27-10-14-12-31-21-3-2-18(29-22(14)21)13-6-15(24)8-16(25)7-13/h2-9,11-12H,10H2,1H3,(H,26,27)
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 635 -35.6n/an/an/an/an/a8.027



Amgen Inc.

US Patent


Assay Description
A PCR product covering residues 1058-1365 of c-Met (c-Met kinase domain) is generated from Human Liver QuickClone cDNA (Invitrogen) using forward pri...

US Patent US9066954 (2015)


BindingDB Entry DOI: 10.7270/Q2N878JD
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM164487
PNG
(US9066954, 343)
Show SMILES O=c1ccc2n(Cc3nnc4ccc(nn34)-c3ccccc3)ccc2[nH]1
Show InChI InChI=1S/C19H14N6O/c26-19-9-7-16-15(20-19)10-11-24(16)12-18-22-21-17-8-6-14(23-25(17)18)13-4-2-1-3-5-13/h1-11H,12H2,(H,20,26)
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 720 -35.3n/an/an/an/an/a8.027



Amgen Inc.

US Patent


Assay Description
A PCR product covering residues 1058-1365 of c-Met (c-Met kinase domain) is generated from Human Liver QuickClone cDNA (Invitrogen) using forward pri...

US Patent US9066954 (2015)


BindingDB Entry DOI: 10.7270/Q2N878JD
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM164425
PNG
(US9066954, 67)
Show SMILES Oc1ccc(Cc2nnc3ccc(cn23)-c2ccccn2)cc1
Show InChI InChI=1S/C18H14N4O/c23-15-7-4-13(5-8-15)11-18-21-20-17-9-6-14(12-22(17)18)16-3-1-2-10-19-16/h1-10,12,23H,11H2
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 758 -35.2n/an/an/an/an/a8.027



Amgen Inc.

US Patent


Assay Description
A PCR product covering residues 1058-1365 of c-Met (c-Met kinase domain) is generated from Human Liver QuickClone cDNA (Invitrogen) using forward pri...

US Patent US9066954 (2015)


BindingDB Entry DOI: 10.7270/Q2N878JD
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM164407
PNG
(US9066954, 21)
Show SMILES Oc1cnc2c(NCc3nnc4ccc(nn34)-c3ccccc3)ccnc2c1
Show InChI InChI=1S/C20H15N7O/c28-14-10-17-20(23-11-14)16(8-9-21-17)22-12-19-25-24-18-7-6-15(26-27(18)19)13-4-2-1-3-5-13/h1-11,28H,12H2,(H,21,22)
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 805 -35.0n/an/an/an/an/a8.027



Amgen Inc.

US Patent


Assay Description
A PCR product covering residues 1058-1365 of c-Met (c-Met kinase domain) is generated from Human Liver QuickClone cDNA (Invitrogen) using forward pri...

US Patent US9066954 (2015)


BindingDB Entry DOI: 10.7270/Q2N878JD
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM164479
PNG
(US9066954, 317)
Show SMILES COc1ccc(Cc2nnc3ccc(nn23)-c2ccccc2)cc1
Show InChI InChI=1S/C19H16N4O/c1-24-16-9-7-14(8-10-16)13-19-21-20-18-12-11-17(22-23(18)19)15-5-3-2-4-6-15/h2-12H,13H2,1H3
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 847 -34.9n/an/an/an/an/a8.027



Amgen Inc.

US Patent


Assay Description
A PCR product covering residues 1058-1365 of c-Met (c-Met kinase domain) is generated from Human Liver QuickClone cDNA (Invitrogen) using forward pri...

US Patent US9066954 (2015)


BindingDB Entry DOI: 10.7270/Q2N878JD
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM164480
PNG
(US9066954, 319)
Show SMILES Oc1ccc(Cc2nnc3ccc(nn23)-c2cccnc2)cc1
Show InChI InChI=1S/C17H13N5O/c23-14-5-3-12(4-6-14)10-17-20-19-16-8-7-15(21-22(16)17)13-2-1-9-18-11-13/h1-9,11,23H,10H2
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 853 -34.9n/an/an/an/an/a8.027



Amgen Inc.

US Patent


Assay Description
A PCR product covering residues 1058-1365 of c-Met (c-Met kinase domain) is generated from Human Liver QuickClone cDNA (Invitrogen) using forward pri...

US Patent US9066954 (2015)


BindingDB Entry DOI: 10.7270/Q2N878JD
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM24469
PNG
(4-({6-phenyl-[1,2,4]triazolo[3,4-a]pyridin-3-yl}me...)
Show SMILES Oc1ccc(Cc2nnc3ccc(cn23)-c2ccccc2)cc1
Show InChI InChI=1S/C19H15N3O/c23-17-9-6-14(7-10-17)12-19-21-20-18-11-8-16(13-22(18)19)15-4-2-1-3-5-15/h1-11,13,23H,12H2
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 1.23E+3 -34.0n/an/an/an/an/a8.027



Amgen Inc.

US Patent


Assay Description
A PCR product covering residues 1058-1365 of c-Met (c-Met kinase domain) is generated from Human Liver QuickClone cDNA (Invitrogen) using forward pri...

US Patent US9066954 (2015)


BindingDB Entry DOI: 10.7270/Q2N878JD
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM164440
PNG
(US9066954, 112)
Show SMILES Fc1cc(F)cc(c1)-c1ccc2nnc(COc3cnc4ccccc4c3)n2n1
Show InChI InChI=1S/C21H13F2N5O/c22-15-7-14(8-16(23)10-15)19-5-6-20-25-26-21(28(20)27-19)12-29-17-9-13-3-1-2-4-18(13)24-11-17/h1-11H,12H2
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 1.58E+3 -33.3n/an/an/an/an/a8.027



Amgen Inc.

US Patent


Assay Description
A PCR product covering residues 1058-1365 of c-Met (c-Met kinase domain) is generated from Human Liver QuickClone cDNA (Invitrogen) using forward pri...

US Patent US9066954 (2015)


BindingDB Entry DOI: 10.7270/Q2N878JD
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM164482
PNG
(US9066954, 324)
Show SMILES COc1ccc2c(CCCc3nnc4ccc(nn34)-c3ccccc3)ccnc2c1
Show InChI InChI=1S/C24H21N5O/c1-30-19-10-11-20-17(14-15-25-22(20)16-19)8-5-9-23-26-27-24-13-12-21(28-29(23)24)18-6-3-2-4-7-18/h2-4,6-7,10-16H,5,8-9H2,1H3
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 1.61E+3 -33.3n/an/an/an/an/a8.027



Amgen Inc.

US Patent


Assay Description
A PCR product covering residues 1058-1365 of c-Met (c-Met kinase domain) is generated from Human Liver QuickClone cDNA (Invitrogen) using forward pri...

US Patent US9066954 (2015)


BindingDB Entry DOI: 10.7270/Q2N878JD
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM164405
PNG
(US9066954, 19)
Show SMILES COc1ccc2c(ccnc2c1)S(=O)Cc1nnc2ccc(nn12)-c1ccccc1
Show InChI InChI=1S/C22H17N5O2S/c1-29-16-7-8-17-19(13-16)23-12-11-20(17)30(28)14-22-25-24-21-10-9-18(26-27(21)22)15-5-3-2-4-6-15/h2-13H,14H2,1H3
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 1.91E+3 -32.9n/an/an/an/an/a8.027



Amgen Inc.

US Patent


Assay Description
A PCR product covering residues 1058-1365 of c-Met (c-Met kinase domain) is generated from Human Liver QuickClone cDNA (Invitrogen) using forward pri...

US Patent US9066954 (2015)


BindingDB Entry DOI: 10.7270/Q2N878JD
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM164421
PNG
(US9066954, 58)
Show SMILES COc1ccc2c(OCc3cnc4ccc(nn34)-c3ccc(F)c(F)c3)ccnc2c1
Show InChI InChI=1S/C23H16F2N4O2/c1-30-16-3-4-17-21(11-16)26-9-8-22(17)31-13-15-12-27-23-7-6-20(28-29(15)23)14-2-5-18(24)19(25)10-14/h2-12H,13H2,1H3
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 2.06E+3 -32.7n/an/an/an/an/a8.027



Amgen Inc.

US Patent


Assay Description
A PCR product covering residues 1058-1365 of c-Met (c-Met kinase domain) is generated from Human Liver QuickClone cDNA (Invitrogen) using forward pri...

US Patent US9066954 (2015)


BindingDB Entry DOI: 10.7270/Q2N878JD
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM164477
PNG
(US9066954, 314)
Show SMILES C(Cc1ccnc2[nH]ccc12)c1nnc2ccc(nn12)-c1ccccc1
Show InChI InChI=1S/C20H16N6/c1-2-4-15(5-3-1)17-7-9-19-24-23-18(26(19)25-17)8-6-14-10-12-21-20-16(14)11-13-22-20/h1-5,7,9-13H,6,8H2,(H,21,22)
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 3.29E+3 -31.5n/an/an/an/an/a8.027



Amgen Inc.

US Patent


Assay Description
A PCR product covering residues 1058-1365 of c-Met (c-Met kinase domain) is generated from Human Liver QuickClone cDNA (Invitrogen) using forward pri...

US Patent US9066954 (2015)


BindingDB Entry DOI: 10.7270/Q2N878JD
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM164415
PNG
(US9066954, 41)
Show SMILES COc1ccc2c(OCc3cnc4ccc(cn34)-c3ccccc3)ccnc2c1
Show InChI InChI=1S/C24H19N3O2/c1-28-20-8-9-21-22(13-20)25-12-11-23(21)29-16-19-14-26-24-10-7-18(15-27(19)24)17-5-3-2-4-6-17/h2-15H,16H2,1H3
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 4.25E+3 -30.9n/an/an/an/an/a8.027



Amgen Inc.

US Patent


Assay Description
A PCR product covering residues 1058-1365 of c-Met (c-Met kinase domain) is generated from Human Liver QuickClone cDNA (Invitrogen) using forward pri...

US Patent US9066954 (2015)


BindingDB Entry DOI: 10.7270/Q2N878JD
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM164401
PNG
(US9066954, 13)
Show SMILES C(c1nnc2ccc(nn12)-c1ccccc1)n1nnc2cnccc12
Show InChI InChI=1S/C17H12N8/c1-2-4-12(5-3-1)13-6-7-16-20-21-17(25(16)22-13)11-24-15-8-9-18-10-14(15)19-23-24/h1-10H,11H2
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 6.67E+3 -29.7n/an/an/an/an/a8.027



Amgen Inc.

US Patent


Assay Description
A PCR product covering residues 1058-1365 of c-Met (c-Met kinase domain) is generated from Human Liver QuickClone cDNA (Invitrogen) using forward pri...

US Patent US9066954 (2015)


BindingDB Entry DOI: 10.7270/Q2N878JD
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM164402
PNG
(US9066954, 14)
Show SMILES C(c1nnc2ccc(nn12)-c1ccccc1)n1cnc2cnccc12
Show InChI InChI=1S/C18H13N7/c1-2-4-13(5-3-1)14-6-7-17-21-22-18(25(17)23-14)11-24-12-20-15-10-19-9-8-16(15)24/h1-10,12H,11H2
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 6.67E+3 -29.7n/an/an/an/an/a8.027



Amgen Inc.

US Patent


Assay Description
A PCR product covering residues 1058-1365 of c-Met (c-Met kinase domain) is generated from Human Liver QuickClone cDNA (Invitrogen) using forward pri...

US Patent US9066954 (2015)


BindingDB Entry DOI: 10.7270/Q2N878JD
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM164400
PNG
(US9066954, 12)
Show SMILES NC(=O)c1ccc2c(OCc3nnc4ccc(nn34)-c3ccccc3)ccnc2c1
Show InChI InChI=1S/C22H16N6O2/c23-22(29)15-6-7-16-18(12-15)24-11-10-19(16)30-13-21-26-25-20-9-8-17(27-28(20)21)14-4-2-1-3-5-14/h1-12H,13H2,(H2,23,29)
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 2.00E+4 -27.0n/an/an/an/an/a8.027



Amgen Inc.

US Patent


Assay Description
A PCR product covering residues 1058-1365 of c-Met (c-Met kinase domain) is generated from Human Liver QuickClone cDNA (Invitrogen) using forward pri...

US Patent US9066954 (2015)


BindingDB Entry DOI: 10.7270/Q2N878JD
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM164483
PNG
(US9066954, 325)
Show SMILES C(Cc1cccnc1)c1nnc2ccc(nn12)-c1ccccc1
Show InChI InChI=1S/C18H15N5/c1-2-6-15(7-3-1)16-9-11-18-21-20-17(23(18)22-16)10-8-14-5-4-12-19-13-14/h1-7,9,11-13H,8,10H2
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 2.00E+4 -27.0n/an/an/an/an/a8.027



Amgen Inc.

US Patent


Assay Description
A PCR product covering residues 1058-1365 of c-Met (c-Met kinase domain) is generated from Human Liver QuickClone cDNA (Invitrogen) using forward pri...

US Patent US9066954 (2015)


BindingDB Entry DOI: 10.7270/Q2N878JD
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM164436
PNG
(US9066954, 87)
Show SMILES CN(C)CC#Cc1cnccc1OCc1nnc2ccc(nn12)-c1ccccc1
Show InChI InChI=1S/C22H20N6O/c1-27(2)14-6-9-18-15-23-13-12-20(18)29-16-22-25-24-21-11-10-19(26-28(21)22)17-7-4-3-5-8-17/h3-5,7-8,10-13,15H,14,16H2,1-2H3
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UniChem
US Patent
 2.00E+4 -27.0n/an/an/an/an/a8.027



Amgen Inc.

US Patent


Assay Description
A PCR product covering residues 1058-1365 of c-Met (c-Met kinase domain) is generated from Human Liver QuickClone cDNA (Invitrogen) using forward pri...

US Patent US9066954 (2015)


BindingDB Entry DOI: 10.7270/Q2N878JD
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%