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USPatent US9108903

Compile data set for download or QSAR
Found 76 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Sodium channel protein type 10 subunit alpha


(Rattus norvegicus (Rat))		BDBM160984
PNG
(US9108903, 49)
Show SMILES COc1cc(CO)ccc1Oc1cc(cc(c1C(=O)Nc1ccc(nc1)C(O)=O)C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C23H16F6N2O6/c1-36-17-6-11(10-32)2-5-16(17)37-18-8-12(22(24,25)26)7-14(23(27,28)29)19(18)20(33)31-13-3-4-15(21(34)35)30-9-13/h2-9,32H,10H2,1H3,(H,31,33)(H,34,35)
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n/an/a 6n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...

US Patent US9108903 (2015)


BindingDB Entry DOI: 10.7270/Q23J3BP9
More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Rattus norvegicus (Rat))		BDBM160986
PNG
(US9108903, 51 | US9108903, 76)
Show SMILES COc1cc(F)ccc1Oc1cc(Cl)c(Cl)cc1C(=O)Nc1ccc(nc1)C(O)=O
Show InChI InChI=1S/C20H13Cl2FN2O5/c1-29-18-6-10(23)2-5-16(18)30-17-8-14(22)13(21)7-12(17)19(26)25-11-3-4-15(20(27)28)24-9-11/h2-9H,1H3,(H,25,26)(H,27,28)
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n/an/a 9n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...

US Patent US9108903 (2015)


BindingDB Entry DOI: 10.7270/Q23J3BP9
More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Rattus norvegicus (Rat))		BDBM160967
PNG
(US9108903, 32)
Show SMILES Cc1cc(F)ccc1Oc1cc(Cl)c(Cl)cc1C(=O)Nc1ccc(nc1)C(O)=O
Show InChI InChI=1S/C20H13Cl2FN2O4/c1-10-6-11(23)2-5-17(10)29-18-8-15(22)14(21)7-13(18)19(26)25-12-3-4-16(20(27)28)24-9-12/h2-9H,1H3,(H,25,26)(H,27,28)
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VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...

US Patent US9108903 (2015)


BindingDB Entry DOI: 10.7270/Q23J3BP9
More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Rattus norvegicus (Rat))		BDBM160953
PNG
(US9108903, 18)
Show SMILES COc1cc(Cl)ccc1Oc1cc(Cl)c(Cl)cc1C(=O)Nc1ccc(cc1)C(O)=O
Show InChI InChI=1S/C21H14Cl3NO5/c1-29-19-8-12(22)4-7-17(19)30-18-10-16(24)15(23)9-14(18)20(26)25-13-5-2-11(3-6-13)21(27)28/h2-10H,1H3,(H,25,26)(H,27,28)
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VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...

US Patent US9108903 (2015)


BindingDB Entry DOI: 10.7270/Q23J3BP9
More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Rattus norvegicus (Rat))		BDBM160947
PNG
(US9108903, 12)
Show SMILES COc1cc(F)ccc1Oc1cc(Cl)c(Cl)cc1C(=O)Nc1ccc(cc1)C(O)=O
Show InChI InChI=1S/C21H14Cl2FNO5/c1-29-19-8-12(24)4-7-17(19)30-18-10-16(23)15(22)9-14(18)20(26)25-13-5-2-11(3-6-13)21(27)28/h2-10H,1H3,(H,25,26)(H,27,28)
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VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...

US Patent US9108903 (2015)


BindingDB Entry DOI: 10.7270/Q23J3BP9
More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Rattus norvegicus (Rat))		BDBM160976
PNG
(US9108903, 41)
Show SMILES OC(=O)c1ccc(NC(=O)c2cc(Cl)c(Cl)cc2Oc2ccc(F)cc2Cl)cn1
Show InChI InChI=1S/C19H10Cl3FN2O4/c20-12-6-11(18(26)25-10-2-3-15(19(27)28)24-8-10)17(7-13(12)21)29-16-4-1-9(23)5-14(16)22/h1-8H,(H,25,26)(H,27,28)
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VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...

US Patent US9108903 (2015)


BindingDB Entry DOI: 10.7270/Q23J3BP9
More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Rattus norvegicus (Rat))		BDBM160986
PNG
(US9108903, 51 | US9108903, 76)
Show SMILES COc1cc(F)ccc1Oc1cc(Cl)c(Cl)cc1C(=O)Nc1ccc(nc1)C(O)=O
Show InChI InChI=1S/C20H13Cl2FN2O5/c1-29-18-6-10(23)2-5-16(18)30-17-8-14(22)13(21)7-12(17)19(26)25-11-3-4-15(20(27)28)24-9-11/h2-9H,1H3,(H,25,26)(H,27,28)
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VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...

US Patent US9108903 (2015)


BindingDB Entry DOI: 10.7270/Q23J3BP9
More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Rattus norvegicus (Rat))		BDBM160983
PNG
(US9108903, 48)
Show SMILES COc1cc(F)ccc1Oc1cc(cc(c1C(=O)Nc1ccc(nc1)C(O)=O)C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C22H13F7N2O5/c1-35-16-8-11(23)2-5-15(16)36-17-7-10(21(24,25)26)6-13(22(27,28)29)18(17)19(32)31-12-3-4-14(20(33)34)30-9-12/h2-9H,1H3,(H,31,32)(H,33,34)
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VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...

US Patent US9108903 (2015)


BindingDB Entry DOI: 10.7270/Q23J3BP9
More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Rattus norvegicus (Rat))		BDBM160974
PNG
(US9108903, 39)
Show SMILES COc1cc(CO)ccc1Oc1cc(Cl)c(Cl)cc1C(=O)Nc1ccc(nc1)C(O)=O
Show InChI InChI=1S/C21H16Cl2N2O6/c1-30-19-6-11(10-26)2-5-17(19)31-18-8-15(23)14(22)7-13(18)20(27)25-12-3-4-16(21(28)29)24-9-12/h2-9,26H,10H2,1H3,(H,25,27)(H,28,29)
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VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...

US Patent US9108903 (2015)


BindingDB Entry DOI: 10.7270/Q23J3BP9
More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Rattus norvegicus (Rat))		BDBM160949
PNG
(US9108903, 14)
Show SMILES Cc1cc(F)ccc1Oc1cc(Cl)c(Cl)cc1C(=O)Nc1ccc(cc1)C(O)=O
Show InChI InChI=1S/C21H14Cl2FNO4/c1-11-8-13(24)4-7-18(11)29-19-10-17(23)16(22)9-15(19)20(26)25-14-5-2-12(3-6-14)21(27)28/h2-10H,1H3,(H,25,26)(H,27,28)
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VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...

US Patent US9108903 (2015)


BindingDB Entry DOI: 10.7270/Q23J3BP9
More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Rattus norvegicus (Rat))		BDBM160936
PNG
(US9108903, 1)
Show SMILES OC(=O)c1ccc(NC(=O)c2ccc(cc2Oc2ccc(F)cc2Cl)C(F)(F)C(F)(F)F)cc1
Show InChI InChI=1S/C22H12ClF6NO4/c23-16-10-13(24)4-8-17(16)34-18-9-12(21(25,26)22(27,28)29)3-7-15(18)19(31)30-14-5-1-11(2-6-14)20(32)33/h1-10H,(H,30,31)(H,32,33)
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VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...

US Patent US9108903 (2015)


BindingDB Entry DOI: 10.7270/Q23J3BP9
More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Rattus norvegicus (Rat))		BDBM160962
PNG
(US9108903, 27)
Show SMILES COc1cc(F)ccc1Oc1cc(ccc1C(=O)Nc1ccc(cc1)C(O)=O)C(F)(F)C(F)(F)F
Show InChI InChI=1S/C23H15F6NO5/c1-34-19-11-14(24)5-9-17(19)35-18-10-13(22(25,26)23(27,28)29)4-8-16(18)20(31)30-15-6-2-12(3-7-15)21(32)33/h2-11H,1H3,(H,30,31)(H,32,33)
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VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...

US Patent US9108903 (2015)


BindingDB Entry DOI: 10.7270/Q23J3BP9
More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Rattus norvegicus (Rat))		BDBM160979
PNG
(US9108903, 44)
Show SMILES OC(=O)c1ccc(NC(=O)c2cc(Cl)c(Cl)cc2Oc2ccc(OC(F)(F)F)cc2)cn1
Show InChI InChI=1S/C20H11Cl2F3N2O5/c21-14-7-13(18(28)27-10-1-6-16(19(29)30)26-9-10)17(8-15(14)22)31-11-2-4-12(5-3-11)32-20(23,24)25/h1-9H,(H,27,28)(H,29,30)
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VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...

US Patent US9108903 (2015)


BindingDB Entry DOI: 10.7270/Q23J3BP9
More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Rattus norvegicus (Rat))		BDBM160938
PNG
(US9108903, 3)
Show SMILES Cc1cc(F)ccc1Oc1cc(ccc1C(=O)Nc1ccc(cc1)C(O)=O)C(F)(F)C(F)(F)F
Show InChI InChI=1S/C23H15F6NO4/c1-12-10-15(24)5-9-18(12)34-19-11-14(22(25,26)23(27,28)29)4-8-17(19)20(31)30-16-6-2-13(3-7-16)21(32)33/h2-11H,1H3,(H,30,31)(H,32,33)
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VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...

US Patent US9108903 (2015)


BindingDB Entry DOI: 10.7270/Q23J3BP9
More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Rattus norvegicus (Rat))		BDBM160955
PNG
(US9108903, 20)
Show SMILES Cc1cc(Cl)ccc1Oc1cc(Cl)c(Cl)cc1C(=O)Nc1ccc(cc1)C(O)=O
Show InChI InChI=1S/C21H14Cl3NO4/c1-11-8-13(22)4-7-18(11)29-19-10-17(24)16(23)9-15(19)20(26)25-14-5-2-12(3-6-14)21(27)28/h2-10H,1H3,(H,25,26)(H,27,28)
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VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...

US Patent US9108903 (2015)


BindingDB Entry DOI: 10.7270/Q23J3BP9
More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Rattus norvegicus (Rat))		BDBM160961
PNG
(US9108903, 26)
Show SMILES OC(=O)c1ccc(NC(=O)c2cc(Cl)c(Cl)cc2Oc2ccc(OC(F)(F)F)cc2)cc1
Show InChI InChI=1S/C21H12Cl2F3NO5/c22-16-9-15(19(28)27-12-3-1-11(2-4-12)20(29)30)18(10-17(16)23)31-13-5-7-14(8-6-13)32-21(24,25)26/h1-10H,(H,27,28)(H,29,30)
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VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...

US Patent US9108903 (2015)


BindingDB Entry DOI: 10.7270/Q23J3BP9
More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Rattus norvegicus (Rat))		BDBM160956
PNG
(US9108903, 21)
Show SMILES COc1cc(CO)ccc1Oc1cc(Cl)c(Cl)cc1C(=O)Nc1ccc(cc1)C(O)=O
Show InChI InChI=1S/C22H17Cl2NO6/c1-30-20-8-12(11-26)2-7-18(20)31-19-10-17(24)16(23)9-15(19)21(27)25-14-5-3-13(4-6-14)22(28)29/h2-10,26H,11H2,1H3,(H,25,27)(H,28,29)
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VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...

US Patent US9108903 (2015)


BindingDB Entry DOI: 10.7270/Q23J3BP9
More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Rattus norvegicus (Rat))		BDBM160977
PNG
(US9108903, 42)
Show SMILES OC(=O)c1ccc(NC(=O)c2cc(Cl)c(Cl)cc2Oc2ccc(F)cc2F)cn1
Show InChI InChI=1S/C19H10Cl2F2N2O4/c20-12-6-11(18(26)25-10-2-3-15(19(27)28)24-8-10)17(7-13(12)21)29-16-4-1-9(22)5-14(16)23/h1-8H,(H,25,26)(H,27,28)
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VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...

US Patent US9108903 (2015)


BindingDB Entry DOI: 10.7270/Q23J3BP9
More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Rattus norvegicus (Rat))		BDBM160987
PNG
(US9108903, 52)
Show SMILES COc1cc(F)ccc1Oc1cc(ccc1C(=O)Nc1ccc(nc1)C(O)=O)C(C)(C)C
Show InChI InChI=1S/C24H23FN2O5/c1-24(2,3)14-5-8-17(22(28)27-16-7-9-18(23(29)30)26-13-16)20(11-14)32-19-10-6-15(25)12-21(19)31-4/h5-13H,1-4H3,(H,27,28)(H,29,30)
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VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...

US Patent US9108903 (2015)


BindingDB Entry DOI: 10.7270/Q23J3BP9
More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Rattus norvegicus (Rat))		BDBM160937
PNG
(US9108903, 2)
Show SMILES OC(=O)c1ccc(NC(=O)c2ccc(cc2Oc2ccc(F)cc2F)C(F)(F)C(F)(F)F)cc1
Show InChI InChI=1S/C22H12F7NO4/c23-13-4-8-17(16(24)10-13)34-18-9-12(21(25,26)22(27,28)29)3-7-15(18)19(31)30-14-5-1-11(2-6-14)20(32)33/h1-10H,(H,30,31)(H,32,33)
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n/an/a 32n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...

US Patent US9108903 (2015)


BindingDB Entry DOI: 10.7270/Q23J3BP9
More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Rattus norvegicus (Rat))		BDBM160958
PNG
(US9108903, 23)
Show SMILES OC(=O)c1ccc(NC(=O)c2cc(Cl)c(Cl)cc2Oc2ccc(F)cc2Cl)cc1
Show InChI InChI=1S/C20H11Cl3FNO4/c21-14-8-13(19(26)25-12-4-1-10(2-5-12)20(27)28)18(9-15(14)22)29-17-6-3-11(24)7-16(17)23/h1-9H,(H,25,26)(H,27,28)
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n/an/a 33n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...

US Patent US9108903 (2015)


BindingDB Entry DOI: 10.7270/Q23J3BP9
More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Rattus norvegicus (Rat))		BDBM160975
PNG
(US9108903, 40)
Show SMILES OCc1ccc(Oc2cc(Cl)c(Cl)cc2C(=O)Nc2ccc(nc2)C(O)=O)cc1F
Show InChI InChI=1S/C20H13Cl2FN2O5/c21-14-6-13(19(27)25-11-2-4-17(20(28)29)24-8-11)18(7-15(14)22)30-12-3-1-10(9-26)16(23)5-12/h1-8,26H,9H2,(H,25,27)(H,28,29)
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VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...

US Patent US9108903 (2015)


BindingDB Entry DOI: 10.7270/Q23J3BP9
More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Rattus norvegicus (Rat))		BDBM160965
PNG
(US9108903, 30)
Show SMILES OC(=O)c1ccc(NC(=O)c2cc(Cl)c(Cl)cc2Oc2ccc(F)cc2)cn1
Show InChI InChI=1S/C19H11Cl2FN2O4/c20-14-7-13(18(25)24-11-3-6-16(19(26)27)23-9-11)17(8-15(14)21)28-12-4-1-10(22)2-5-12/h1-9H,(H,24,25)(H,26,27)
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VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...

US Patent US9108903 (2015)


BindingDB Entry DOI: 10.7270/Q23J3BP9
More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Rattus norvegicus (Rat))		BDBM161007
PNG
(US9108903, 72)
Show SMILES COc1cc(F)ccc1Oc1cc(ccc1C(=O)Nc1ccc(nc1)C(O)=O)C(F)(F)C(F)(F)F
Show InChI InChI=1S/C22H14F6N2O5/c1-34-18-9-12(23)3-7-16(18)35-17-8-11(21(24,25)22(26,27)28)2-5-14(17)19(31)30-13-4-6-15(20(32)33)29-10-13/h2-10H,1H3,(H,30,31)(H,32,33)
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VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...

US Patent US9108903 (2015)


BindingDB Entry DOI: 10.7270/Q23J3BP9
More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Rattus norvegicus (Rat))		BDBM160945
PNG
(US9108903, 10)
Show SMILES COc1cc(F)ccc1Oc1cc(cc(c1C(=O)Nc1ccc(cc1)C(O)=O)C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C23H14F7NO5/c1-35-17-10-13(24)4-7-16(17)36-18-9-12(22(25,26)27)8-15(23(28,29)30)19(18)20(32)31-14-5-2-11(3-6-14)21(33)34/h2-10H,1H3,(H,31,32)(H,33,34)
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VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...

US Patent US9108903 (2015)


BindingDB Entry DOI: 10.7270/Q23J3BP9
More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Rattus norvegicus (Rat))		BDBM160942
PNG
(US9108903, 7)
Show SMILES OC(=O)c1ccc(NC(=O)c2ccc(cc2Oc2ccc(OC(F)(F)F)cc2)C(F)(F)F)cc1
Show InChI InChI=1S/C22H13F6NO5/c23-21(24,25)13-3-10-17(19(30)29-14-4-1-12(2-5-14)20(31)32)18(11-13)33-15-6-8-16(9-7-15)34-22(26,27)28/h1-11H,(H,29,30)(H,31,32)
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VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...

US Patent US9108903 (2015)


BindingDB Entry DOI: 10.7270/Q23J3BP9
More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Rattus norvegicus (Rat))		BDBM160971
PNG
(US9108903, 36)
Show SMILES COc1cc(Cl)ccc1Oc1cc(Cl)c(Cl)cc1C(=O)Nc1ccc(nc1)C(O)=O
Show InChI InChI=1S/C20H13Cl3N2O5/c1-29-18-6-10(21)2-5-16(18)30-17-8-14(23)13(22)7-12(17)19(26)25-11-3-4-15(20(27)28)24-9-11/h2-9H,1H3,(H,25,26)(H,27,28)
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VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...

US Patent US9108903 (2015)


BindingDB Entry DOI: 10.7270/Q23J3BP9
More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Rattus norvegicus (Rat))		BDBM161000
PNG
(US9108903, 65)
Show SMILES COc1cc(CO)ccc1Oc1ccc(cc1C(=O)Nc1ccc(nc1)C(O)=O)C(F)(F)F
Show InChI InChI=1S/C22H17F3N2O6/c1-32-19-8-12(11-28)2-6-18(19)33-17-7-3-13(22(23,24)25)9-15(17)20(29)27-14-4-5-16(21(30)31)26-10-14/h2-10,28H,11H2,1H3,(H,27,29)(H,30,31)
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VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...

US Patent US9108903 (2015)


BindingDB Entry DOI: 10.7270/Q23J3BP9
More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Rattus norvegicus (Rat))		BDBM160982
PNG
(US9108903, 47)
Show SMILES Cc1cc(F)ccc1Oc1cc(cc(c1C(=O)Nc1ccc(nc1)C(O)=O)C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C22H13F7N2O4/c1-10-6-12(23)2-5-16(10)35-17-8-11(21(24,25)26)7-14(22(27,28)29)18(17)19(32)31-13-3-4-15(20(33)34)30-9-13/h2-9H,1H3,(H,31,32)(H,33,34)
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VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...

US Patent US9108903 (2015)


BindingDB Entry DOI: 10.7270/Q23J3BP9
More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Rattus norvegicus (Rat))		BDBM160972
PNG
(US9108903, 37)
Show SMILES OC(=O)c1ccc(NC(=O)c2cc(Cl)c(Cl)cc2Oc2ccccc2OC(F)F)cn1
Show InChI InChI=1S/C20H12Cl2F2N2O5/c21-12-7-11(18(27)26-10-5-6-14(19(28)29)25-9-10)17(8-13(12)22)30-15-3-1-2-4-16(15)31-20(23)24/h1-9,20H,(H,26,27)(H,28,29)
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VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...

US Patent US9108903 (2015)


BindingDB Entry DOI: 10.7270/Q23J3BP9
More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Rattus norvegicus (Rat))		BDBM160988
PNG
(US9108903, 53)
Show SMILES Cc1cc(F)ccc1Oc1cc(ccc1C(=O)Nc1ccc(nc1)C(O)=O)C(C)(C)C
Show InChI InChI=1S/C24H23FN2O4/c1-14-11-16(25)6-10-20(14)31-21-12-15(24(2,3)4)5-8-18(21)22(28)27-17-7-9-19(23(29)30)26-13-17/h5-13H,1-4H3,(H,27,28)(H,29,30)
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VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...

US Patent US9108903 (2015)


BindingDB Entry DOI: 10.7270/Q23J3BP9
More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Rattus norvegicus (Rat))		BDBM160970
PNG
(US9108903, 35)
Show SMILES OC(=O)c1ccc(NC(=O)c2cc(Cl)c(Cl)cc2Oc2ccc(OCC(F)(F)F)cc2)cn1
Show InChI InChI=1S/C21H13Cl2F3N2O5/c22-15-7-14(19(29)28-11-1-6-17(20(30)31)27-9-11)18(8-16(15)23)33-13-4-2-12(3-5-13)32-10-21(24,25)26/h1-9H,10H2,(H,28,29)(H,30,31)
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VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...

US Patent US9108903 (2015)


BindingDB Entry DOI: 10.7270/Q23J3BP9
More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Rattus norvegicus (Rat))		BDBM160969
PNG
(US9108903, 34)
Show SMILES OCc1ccc(Oc2cc(Cl)c(Cl)cc2C(=O)Nc2ccc(nc2)C(O)=O)c(F)c1
Show InChI InChI=1S/C20H13Cl2FN2O5/c21-13-6-12(19(27)25-11-2-3-16(20(28)29)24-8-11)18(7-14(13)22)30-17-4-1-10(9-26)5-15(17)23/h1-8,26H,9H2,(H,25,27)(H,28,29)
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VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...

US Patent US9108903 (2015)


BindingDB Entry DOI: 10.7270/Q23J3BP9
More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Rattus norvegicus (Rat))		BDBM160959
PNG
(US9108903, 24)
Show SMILES OC(=O)c1ccc(NC(=O)c2cc(Cl)c(Cl)cc2Oc2ccc(F)cc2F)cc1
Show InChI InChI=1S/C20H11Cl2F2NO4/c21-14-8-13(19(26)25-12-4-1-10(2-5-12)20(27)28)18(9-15(14)22)29-17-6-3-11(23)7-16(17)24/h1-9H,(H,25,26)(H,27,28)
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VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...

US Patent US9108903 (2015)


BindingDB Entry DOI: 10.7270/Q23J3BP9
More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Rattus norvegicus (Rat))		BDBM160948
PNG
(US9108903, 13)
Show SMILES OC(=O)c1ccc(NC(=O)c2cc(Cl)c(Cl)cc2Oc2ccc(F)cc2)cc1
Show InChI InChI=1S/C20H12Cl2FNO4/c21-16-9-15(19(25)24-13-5-1-11(2-6-13)20(26)27)18(10-17(16)22)28-14-7-3-12(23)4-8-14/h1-10H,(H,24,25)(H,26,27)
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VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...

US Patent US9108903 (2015)


BindingDB Entry DOI: 10.7270/Q23J3BP9
More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Rattus norvegicus (Rat))		BDBM160939
PNG
(US9108903, 4)
Show SMILES OC(=O)c1ccc(NC(=O)c2ccc(cc2Oc2ccc(F)cc2Cl)C(F)(F)F)cc1
Show InChI InChI=1S/C21H12ClF4NO4/c22-16-10-13(23)4-8-17(16)31-18-9-12(21(24,25)26)3-7-15(18)19(28)27-14-5-1-11(2-6-14)20(29)30/h1-10H,(H,27,28)(H,29,30)
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VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...

US Patent US9108903 (2015)


BindingDB Entry DOI: 10.7270/Q23J3BP9
More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Rattus norvegicus (Rat))		BDBM160940
PNG
(US9108903, 5)
Show SMILES Cc1cc(F)ccc1Oc1cc(ccc1C(=O)Nc1ccc(cc1)C(O)=O)C(F)(F)F
Show InChI InChI=1S/C22H15F4NO4/c1-12-10-15(23)5-9-18(12)31-19-11-14(22(24,25)26)4-8-17(19)20(28)27-16-6-2-13(3-7-16)21(29)30/h2-11H,1H3,(H,27,28)(H,29,30)
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VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...

US Patent US9108903 (2015)


BindingDB Entry DOI: 10.7270/Q23J3BP9
More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Rattus norvegicus (Rat))		BDBM160952
PNG
(US9108903, 17)
Show SMILES OC(=O)c1ccc(NC(=O)c2cc(Cl)c(Cl)cc2Oc2ccc(OCC(F)(F)F)cc2)cc1
Show InChI InChI=1S/C22H14Cl2F3NO5/c23-17-9-16(20(29)28-13-3-1-12(2-4-13)21(30)31)19(10-18(17)24)33-15-7-5-14(6-8-15)32-11-22(25,26)27/h1-10H,11H2,(H,28,29)(H,30,31)
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VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...

US Patent US9108903 (2015)


BindingDB Entry DOI: 10.7270/Q23J3BP9
More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Rattus norvegicus (Rat))		BDBM160980
PNG
(US9108903, 45)
Show SMILES COc1ccccc1Oc1cc(cc(c1C(=O)Nc1ccc(nc1)C(O)=O)C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C22H14F6N2O5/c1-34-15-4-2-3-5-16(15)35-17-9-11(21(23,24)25)8-13(22(26,27)28)18(17)19(31)30-12-6-7-14(20(32)33)29-10-12/h2-10H,1H3,(H,30,31)(H,32,33)
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VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...

US Patent US9108903 (2015)


BindingDB Entry DOI: 10.7270/Q23J3BP9
More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Rattus norvegicus (Rat))		BDBM160978
PNG
(US9108903, 43)
Show SMILES OCc1ccc(Oc2cc(Cl)c(Cl)cc2C(=O)Nc2ccc(nc2)C(O)=O)c(Cl)c1
Show InChI InChI=1S/C20H13Cl3N2O5/c21-13-6-12(19(27)25-11-2-3-16(20(28)29)24-8-11)18(7-14(13)22)30-17-4-1-10(9-26)5-15(17)23/h1-8,26H,9H2,(H,25,27)(H,28,29)
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VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...

US Patent US9108903 (2015)


BindingDB Entry DOI: 10.7270/Q23J3BP9
More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Rattus norvegicus (Rat))		BDBM160954
PNG
(US9108903, 19)
Show SMILES OC(=O)c1ccc(NC(=O)c2cc(Cl)c(Cl)cc2Oc2ccccc2OC(F)F)cc1
Show InChI InChI=1S/C21H13Cl2F2NO5/c22-14-9-13(19(27)26-12-7-5-11(6-8-12)20(28)29)18(10-15(14)23)30-16-3-1-2-4-17(16)31-21(24)25/h1-10,21H,(H,26,27)(H,28,29)
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VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...

US Patent US9108903 (2015)


BindingDB Entry DOI: 10.7270/Q23J3BP9
More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Rattus norvegicus (Rat))		BDBM160981
PNG
(US9108903, 46)
Show SMILES OCc1ccc(Oc2cc(cc(c2C(=O)Nc2ccc(nc2)C(O)=O)C(F)(F)F)C(F)(F)F)cc1
Show InChI InChI=1S/C22H14F6N2O5/c23-21(24,25)12-7-15(22(26,27)28)18(17(8-12)35-14-4-1-11(10-31)2-5-14)19(32)30-13-3-6-16(20(33)34)29-9-13/h1-9,31H,10H2,(H,30,32)(H,33,34)
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VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...

US Patent US9108903 (2015)


BindingDB Entry DOI: 10.7270/Q23J3BP9
More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Rattus norvegicus (Rat))		BDBM161001
PNG
(US9108903, 66)
Show SMILES COc1cc(Cl)ccc1Oc1ccc(cc1C(=O)Nc1ccc(nc1)C(O)=O)C(F)(F)F
Show InChI InChI=1S/C21H14ClF3N2O5/c1-31-18-9-12(22)3-7-17(18)32-16-6-2-11(21(23,24)25)8-14(16)19(28)27-13-4-5-15(20(29)30)26-10-13/h2-10H,1H3,(H,27,28)(H,29,30)
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n/an/a 68n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...

US Patent US9108903 (2015)


BindingDB Entry DOI: 10.7270/Q23J3BP9
More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Rattus norvegicus (Rat))		BDBM160973
PNG
(US9108903, 38)
Show SMILES Cc1cc(Cl)ccc1Oc1cc(Cl)c(Cl)cc1C(=O)Nc1ccc(nc1)C(O)=O
Show InChI InChI=1S/C20H13Cl3N2O4/c1-10-6-11(21)2-5-17(10)29-18-8-15(23)14(22)7-13(18)19(26)25-12-3-4-16(20(27)28)24-9-12/h2-9H,1H3,(H,25,26)(H,27,28)
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n/an/a 74n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...

US Patent US9108903 (2015)


BindingDB Entry DOI: 10.7270/Q23J3BP9
More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Rattus norvegicus (Rat))		BDBM160957
PNG
(US9108903, 22)
Show SMILES OCc1ccc(Oc2cc(Cl)c(Cl)cc2C(=O)Nc2ccc(cc2)C(O)=O)cc1F
Show InChI InChI=1S/C21H14Cl2FNO5/c22-16-8-15(20(27)25-13-4-1-11(2-5-13)21(28)29)19(9-17(16)23)30-14-6-3-12(10-26)18(24)7-14/h1-9,26H,10H2,(H,25,27)(H,28,29)
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n/an/a 78n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...

US Patent US9108903 (2015)


BindingDB Entry DOI: 10.7270/Q23J3BP9
More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Rattus norvegicus (Rat))		BDBM161002
PNG
(US9108903, 67)
Show SMILES Cc1cc(CO)ccc1Oc1ccc(cc1C(=O)Nc1ccc(nc1)C(O)=O)C(F)(F)F
Show InChI InChI=1S/C22H17F3N2O5/c1-12-8-13(11-28)2-6-18(12)32-19-7-3-14(22(23,24)25)9-16(19)20(29)27-15-4-5-17(21(30)31)26-10-15/h2-10,28H,11H2,1H3,(H,27,29)(H,30,31)
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n/an/a 79n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...

US Patent US9108903 (2015)


BindingDB Entry DOI: 10.7270/Q23J3BP9
More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Rattus norvegicus (Rat))		BDBM160993
PNG
(US9108903, 58)
Show SMILES OC(=O)c1ccc(NC(=O)c2cc(ccc2Oc2ccc(F)cc2Cl)C(F)(F)F)cn1
Show InChI InChI=1S/C20H11ClF4N2O4/c21-14-8-11(22)2-6-17(14)31-16-5-1-10(20(23,24)25)7-13(16)18(28)27-12-3-4-15(19(29)30)26-9-12/h1-9H,(H,27,28)(H,29,30)
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n/an/a 80n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...

US Patent US9108903 (2015)


BindingDB Entry DOI: 10.7270/Q23J3BP9
More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Rattus norvegicus (Rat))		BDBM160960
PNG
(US9108903, 25)
Show SMILES OCc1ccc(Oc2cc(Cl)c(Cl)cc2C(=O)Nc2ccc(cc2)C(O)=O)c(Cl)c1
Show InChI InChI=1S/C21H14Cl3NO5/c22-15-8-14(20(27)25-13-4-2-12(3-5-13)21(28)29)19(9-16(15)23)30-18-6-1-11(10-26)7-17(18)24/h1-9,26H,10H2,(H,25,27)(H,28,29)
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n/an/a 92n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...

US Patent US9108903 (2015)


BindingDB Entry DOI: 10.7270/Q23J3BP9
More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Rattus norvegicus (Rat))		BDBM160992
PNG
(US9108903, 57)
Show SMILES COc1cc(F)ccc1Oc1ccc(cc1C(=O)Nc1ccc(nc1)C(O)=O)C(F)(F)F
Show InChI InChI=1S/C21H14F4N2O5/c1-31-18-9-12(22)3-7-17(18)32-16-6-2-11(21(23,24)25)8-14(16)19(28)27-13-4-5-15(20(29)30)26-10-13/h2-10H,1H3,(H,27,28)(H,29,30)
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n/an/a 96n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...

US Patent US9108903 (2015)


BindingDB Entry DOI: 10.7270/Q23J3BP9
More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Rattus norvegicus (Rat))		BDBM161010
PNG
(US9108903, 75)
Show SMILES Cc1cc(F)ccc1Oc1ccc(cc1C(=O)Nc1ccc(nc1)C(O)=O)C(F)(F)F
Show InChI InChI=1S/C21H14F4N2O4/c1-11-8-13(22)3-7-17(11)31-18-6-2-12(21(23,24)25)9-15(18)19(28)27-14-4-5-16(20(29)30)26-10-14/h2-10H,1H3,(H,27,28)(H,29,30)
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n/an/a 108n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...

US Patent US9108903 (2015)


BindingDB Entry DOI: 10.7270/Q23J3BP9
More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Rattus norvegicus (Rat))		BDBM161008
PNG
(US9108903, 73)
Show SMILES OC(=O)c1ccc(NC(=O)c2ccc(cc2Oc2ccc(F)cc2)C(F)(F)C(F)(F)F)cn1
Show InChI InChI=1S/C21H12F6N2O4/c22-12-2-5-14(6-3-12)33-17-9-11(20(23,24)21(25,26)27)1-7-15(17)18(30)29-13-4-8-16(19(31)32)28-10-13/h1-10H,(H,29,30)(H,31,32)
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n/an/a 110n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...

US Patent US9108903 (2015)


BindingDB Entry DOI: 10.7270/Q23J3BP9
More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Rattus norvegicus (Rat))		BDBM160951
PNG
(US9108903, 16)
Show SMILES OCc1ccc(Oc2cc(Cl)c(Cl)cc2C(=O)Nc2ccc(cc2)C(O)=O)c(F)c1
Show InChI InChI=1S/C21H14Cl2FNO5/c22-15-8-14(20(27)25-13-4-2-12(3-5-13)21(28)29)19(9-16(15)23)30-18-6-1-11(10-26)7-17(18)24/h1-9,26H,10H2,(H,25,27)(H,28,29)
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n/an/a 115n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...

US Patent US9108903 (2015)


BindingDB Entry DOI: 10.7270/Q23J3BP9
More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Rattus norvegicus (Rat))		BDBM160985
PNG
(US9108903, 50)
Show SMILES OC(=O)c1ccc(NC(=O)c2c(Oc3ccc(F)cc3)cc(cc2C(F)(F)F)C(F)(F)F)cn1
Show InChI InChI=1S/C21H11F7N2O4/c22-11-1-4-13(5-2-11)34-16-8-10(20(23,24)25)7-14(21(26,27)28)17(16)18(31)30-12-3-6-15(19(32)33)29-9-12/h1-9H,(H,30,31)(H,32,33)
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n/an/a 130n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...

US Patent US9108903 (2015)


BindingDB Entry DOI: 10.7270/Q23J3BP9
More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Rattus norvegicus (Rat))		BDBM160944
PNG
(US9108903, 9)
Show SMILES Cc1cc(F)ccc1Oc1cc(cc(c1C(=O)Nc1ccc(cc1)C(O)=O)C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C23H14F7NO4/c1-11-8-14(24)4-7-17(11)35-18-10-13(22(25,26)27)9-16(23(28,29)30)19(18)20(32)31-15-5-2-12(3-6-15)21(33)34/h2-10H,1H3,(H,31,32)(H,33,34)
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n/an/a 130n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...

US Patent US9108903 (2015)


BindingDB Entry DOI: 10.7270/Q23J3BP9
More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Rattus norvegicus (Rat))		BDBM161004
PNG
(US9108903, 69)
Show SMILES COc1c(F)cccc1Oc1ccc(cc1C(=O)Nc1ccc(nc1)C(O)=O)C(F)(F)F
Show InChI InChI=1S/C21H14F4N2O5/c1-31-18-14(22)3-2-4-17(18)32-16-8-5-11(21(23,24)25)9-13(16)19(28)27-12-6-7-15(20(29)30)26-10-12/h2-10H,1H3,(H,27,28)(H,29,30)
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n/an/a 135n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...

US Patent US9108903 (2015)


BindingDB Entry DOI: 10.7270/Q23J3BP9
More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Rattus norvegicus (Rat))		BDBM161003
PNG
(US9108903, 68)
Show SMILES OCc1ccc(Oc2ccc(cc2C(=O)Nc2ccc(nc2)C(O)=O)C(F)(F)F)c(Cl)c1
Show InChI InChI=1S/C21H14ClF3N2O5/c22-15-7-11(10-28)1-5-18(15)32-17-6-2-12(21(23,24)25)8-14(17)19(29)27-13-3-4-16(20(30)31)26-9-13/h1-9,28H,10H2,(H,27,29)(H,30,31)
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n/an/a 135n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...

US Patent US9108903 (2015)


BindingDB Entry DOI: 10.7270/Q23J3BP9
More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Rattus norvegicus (Rat))		BDBM160941
PNG
(US9108903, 6)
Show SMILES OC(=O)c1ccc(NC(=O)c2ccc(cc2Oc2ccc(F)cc2F)C(F)(F)F)cc1
Show InChI InChI=1S/C21H12F5NO4/c22-13-4-8-17(16(23)10-13)31-18-9-12(21(24,25)26)3-7-15(18)19(28)27-14-5-1-11(2-6-14)20(29)30/h1-10H,(H,27,28)(H,29,30)
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n/an/a 145n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...

US Patent US9108903 (2015)


BindingDB Entry DOI: 10.7270/Q23J3BP9
More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Rattus norvegicus (Rat))		BDBM160996
PNG
(US9108903, 61)
Show SMILES Cc1cc(Cl)ccc1Oc1ccc(cc1C(=O)Nc1ccc(nc1)C(O)=O)C(F)(F)F
Show InChI InChI=1S/C21H14ClF3N2O4/c1-11-8-13(22)3-7-17(11)31-18-6-2-12(21(23,24)25)9-15(18)19(28)27-14-4-5-16(20(29)30)26-10-14/h2-10H,1H3,(H,27,28)(H,29,30)
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n/an/a 145n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...

US Patent US9108903 (2015)


BindingDB Entry DOI: 10.7270/Q23J3BP9
More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Rattus norvegicus (Rat))		BDBM160989
PNG
(US9108903, 54)
Show SMILES CC(C)(C)c1ccc(C(=O)Nc2ccc(nc2)C(O)=O)c(Oc2ccc(F)cc2)c1
Show InChI InChI=1S/C23H21FN2O4/c1-23(2,3)14-4-10-18(20(12-14)30-17-8-5-15(24)6-9-17)21(27)26-16-7-11-19(22(28)29)25-13-16/h4-13H,1-3H3,(H,26,27)(H,28,29)
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n/an/a 180n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...

US Patent US9108903 (2015)


BindingDB Entry DOI: 10.7270/Q23J3BP9
More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Rattus norvegicus (Rat))		BDBM160968
PNG
(US9108903, 33)
Show SMILES OC(=O)c1ccc(NC(=O)c2cc(Cl)c(Cl)cc2Oc2ccccc2)cn1
Show InChI InChI=1S/C19H12Cl2N2O4/c20-14-8-13(17(9-15(14)21)27-12-4-2-1-3-5-12)18(24)23-11-6-7-16(19(25)26)22-10-11/h1-10H,(H,23,24)(H,25,26)
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n/an/a 190n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...

US Patent US9108903 (2015)


BindingDB Entry DOI: 10.7270/Q23J3BP9
More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Rattus norvegicus (Rat))		BDBM160963
PNG
(US9108903, 28 | US9108903, 29)
Show SMILES Cc1cc(F)ccc1Oc1ccc(cc1C(=O)Nc1ccc(cc1)C(O)=O)C(F)(F)F
Show InChI InChI=1S/C22H15F4NO4/c1-12-10-15(23)5-9-18(12)31-19-8-4-14(22(24,25)26)11-17(19)20(28)27-16-6-2-13(3-7-16)21(29)30/h2-11H,1H3,(H,27,28)(H,29,30)
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n/an/a 245n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...

US Patent US9108903 (2015)


BindingDB Entry DOI: 10.7270/Q23J3BP9
More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Rattus norvegicus (Rat))		BDBM160991
PNG
(US9108903, 56)
Show SMILES OC(=O)c1ccc(NC(=O)c2ccc(cc2Oc2ccc(F)cc2)C(F)(F)F)cn1
Show InChI InChI=1S/C20H12F4N2O4/c21-12-2-5-14(6-3-12)30-17-9-11(20(22,23)24)1-7-15(17)18(27)26-13-4-8-16(19(28)29)25-10-13/h1-10H,(H,26,27)(H,28,29)
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n/an/a 250n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...

US Patent US9108903 (2015)


BindingDB Entry DOI: 10.7270/Q23J3BP9
More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Rattus norvegicus (Rat))		BDBM161006
PNG
(US9108903, 71)
Show SMILES OC(=O)c1ccc(NC(=O)c2cc(ccc2Oc2ccc(F)cc2)C(F)(F)F)cn1
Show InChI InChI=1S/C20H12F4N2O4/c21-12-2-5-14(6-3-12)30-17-8-1-11(20(22,23)24)9-15(17)18(27)26-13-4-7-16(19(28)29)25-10-13/h1-10H,(H,26,27)(H,28,29)
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n/an/a 285n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...

US Patent US9108903 (2015)


BindingDB Entry DOI: 10.7270/Q23J3BP9
More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Rattus norvegicus (Rat))		BDBM160950
PNG
(US9108903, 15)
Show SMILES OC(=O)c1ccc(NC(=O)c2cc(Cl)c(Cl)cc2Oc2ccccc2)cc1
Show InChI InChI=1S/C20H13Cl2NO4/c21-16-10-15(18(11-17(16)22)27-14-4-2-1-3-5-14)19(24)23-13-8-6-12(7-9-13)20(25)26/h1-11H,(H,23,24)(H,25,26)
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VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...

US Patent US9108903 (2015)


BindingDB Entry DOI: 10.7270/Q23J3BP9
More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Rattus norvegicus (Rat))		BDBM160946
PNG
(US9108903, 11)
Show SMILES OC(=O)c1ccc(NC(=O)c2c(Oc3ccc(F)cc3)cc(cc2C(F)(F)F)C(F)(F)F)cc1
Show InChI InChI=1S/C22H12F7NO4/c23-13-3-7-15(8-4-13)34-17-10-12(21(24,25)26)9-16(22(27,28)29)18(17)19(31)30-14-5-1-11(2-6-14)20(32)33/h1-10H,(H,30,31)(H,32,33)
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n/an/a 305n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...

US Patent US9108903 (2015)


BindingDB Entry DOI: 10.7270/Q23J3BP9
More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Rattus norvegicus (Rat))		BDBM160963
PNG
(US9108903, 28 | US9108903, 29)
Show SMILES Cc1cc(F)ccc1Oc1ccc(cc1C(=O)Nc1ccc(cc1)C(O)=O)C(F)(F)F
Show InChI InChI=1S/C22H15F4NO4/c1-12-10-15(23)5-9-18(12)31-19-8-4-14(22(24,25)26)11-17(19)20(28)27-16-6-2-13(3-7-16)21(29)30/h2-11H,1H3,(H,27,28)(H,29,30)
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n/an/a 340n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...

US Patent US9108903 (2015)


BindingDB Entry DOI: 10.7270/Q23J3BP9
More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Rattus norvegicus (Rat))		BDBM160997
PNG
(US9108903, 62)
Show SMILES COc1ccccc1Oc1ccc(cc1C(=O)Nc1ccc(nc1)C(O)=O)C(F)(F)F
Show InChI InChI=1S/C21H15F3N2O5/c1-30-17-4-2-3-5-18(17)31-16-9-6-12(21(22,23)24)10-14(16)19(27)26-13-7-8-15(20(28)29)25-11-13/h2-11H,1H3,(H,26,27)(H,28,29)
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n/an/a 370n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...

US Patent US9108903 (2015)


BindingDB Entry DOI: 10.7270/Q23J3BP9
More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Rattus norvegicus (Rat))		BDBM160943
PNG
(US9108903, 8)
Show SMILES OC(=O)c1ccc(NC(=O)c2c(Oc3ccc(F)cc3F)cc(cc2C(F)(F)F)C(F)(F)F)cc1
Show InChI InChI=1S/C22H11F8NO4/c23-12-3-6-16(15(24)9-12)35-17-8-11(21(25,26)27)7-14(22(28,29)30)18(17)19(32)31-13-4-1-10(2-5-13)20(33)34/h1-9H,(H,31,32)(H,33,34)
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n/an/a 405n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...

US Patent US9108903 (2015)


BindingDB Entry DOI: 10.7270/Q23J3BP9
More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Rattus norvegicus (Rat))		BDBM161009
PNG
(US9108903, 74)
Show SMILES OC(=O)c1ccc(NC(=O)c2c(Oc3ccc(F)cc3Cl)cccc2C(F)(F)F)cn1
Show InChI InChI=1S/C20H11ClF4N2O4/c21-13-8-10(22)4-7-15(13)31-16-3-1-2-12(20(23,24)25)17(16)18(28)27-11-5-6-14(19(29)30)26-9-11/h1-9H,(H,27,28)(H,29,30)
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n/an/a 405n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...

US Patent US9108903 (2015)


BindingDB Entry DOI: 10.7270/Q23J3BP9
More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Rattus norvegicus (Rat))		BDBM160998
PNG
(US9108903, 63)
Show SMILES OC(=O)c1ccc(NC(=O)c2cc(ccc2Oc2ccccc2Cl)C(F)(F)F)cn1
Show InChI InChI=1S/C20H12ClF3N2O4/c21-14-3-1-2-4-17(14)30-16-8-5-11(20(22,23)24)9-13(16)18(27)26-12-6-7-15(19(28)29)25-10-12/h1-10H,(H,26,27)(H,28,29)
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n/an/a 430n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...

US Patent US9108903 (2015)


BindingDB Entry DOI: 10.7270/Q23J3BP9
More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Rattus norvegicus (Rat))		BDBM160995
PNG
(US9108903, 60)
Show SMILES OC(=O)c1ccc(NC(=O)c2cc(ccc2Oc2ccccc2OC(F)F)C(F)(F)F)cn1
Show InChI InChI=1S/C21H13F5N2O5/c22-20(23)33-17-4-2-1-3-16(17)32-15-8-5-11(21(24,25)26)9-13(15)18(29)28-12-6-7-14(19(30)31)27-10-12/h1-10,20H,(H,28,29)(H,30,31)
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n/an/a 650n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...

US Patent US9108903 (2015)


BindingDB Entry DOI: 10.7270/Q23J3BP9
More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Rattus norvegicus (Rat))		BDBM160994
PNG
(US9108903, 59)
Show SMILES COc1ccc(F)cc1Oc1ccc(cc1C(=O)Nc1ccc(nc1)C(O)=O)C(F)(F)F
Show InChI InChI=1S/C21H14F4N2O5/c1-31-17-7-3-12(22)9-18(17)32-16-6-2-11(21(23,24)25)8-14(16)19(28)27-13-4-5-15(20(29)30)26-10-13/h2-10H,1H3,(H,27,28)(H,29,30)
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n/an/a 740n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...

US Patent US9108903 (2015)


BindingDB Entry DOI: 10.7270/Q23J3BP9
More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Rattus norvegicus (Rat))		BDBM160999
PNG
(US9108903, 64)
Show SMILES CC(C)Oc1ccccc1Oc1ccc(cc1C(=O)Nc1ccc(nc1)C(O)=O)C(F)(F)F
Show InChI InChI=1S/C23H19F3N2O5/c1-13(2)32-19-5-3-4-6-20(19)33-18-10-7-14(23(24,25)26)11-16(18)21(29)28-15-8-9-17(22(30)31)27-12-15/h3-13H,1-2H3,(H,28,29)(H,30,31)
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n/an/a 755n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...

US Patent US9108903 (2015)


BindingDB Entry DOI: 10.7270/Q23J3BP9
More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Rattus norvegicus (Rat))		BDBM161005
PNG
(US9108903, 70)
Show SMILES OC(=O)c1ccc(NC(=O)c2cc(ccc2Oc2ccccc2)C(F)(F)F)cn1
Show InChI InChI=1S/C20H13F3N2O4/c21-20(22,23)12-6-9-17(29-14-4-2-1-3-5-14)15(10-12)18(26)25-13-7-8-16(19(27)28)24-11-13/h1-11H,(H,25,26)(H,27,28)
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n/an/a 985n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...

US Patent US9108903 (2015)


BindingDB Entry DOI: 10.7270/Q23J3BP9
More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Rattus norvegicus (Rat))		BDBM160966
PNG
(US9108903, 31)
Show SMILES CC(C)CCOc1ccc(Oc2cc(Cl)c(Cl)cc2C(=O)Nc2ccc(nc2)C(O)=O)cc1
Show InChI InChI=1S/C24H22Cl2N2O5/c1-14(2)9-10-32-16-4-6-17(7-5-16)33-22-12-20(26)19(25)11-18(22)23(29)28-15-3-8-21(24(30)31)27-13-15/h3-8,11-14H,9-10H2,1-2H3,(H,28,29)(H,30,31)
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n/an/a 1.00E+3n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...

US Patent US9108903 (2015)


BindingDB Entry DOI: 10.7270/Q23J3BP9
More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Rattus norvegicus (Rat))		BDBM160990
PNG
(US9108903, 55)
Show SMILES OC(=O)c1ccc(NC(=O)c2ccccc2Oc2ccc(F)cc2)cn1
Show InChI InChI=1S/C19H13FN2O4/c20-12-5-8-14(9-6-12)26-17-4-2-1-3-15(17)18(23)22-13-7-10-16(19(24)25)21-11-13/h1-11H,(H,22,23)(H,24,25)
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n/an/a 4.35E+3n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...

US Patent US9108903 (2015)


BindingDB Entry DOI: 10.7270/Q23J3BP9
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%