BindingDB logo
myBDB logout

USPatent US9175003

Compile Data Set for Download or QSAR

Found 234 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Glucagon-like peptide 1 receptor


(Homo sapiens (Human))		BDBM189944
PNG
(US9175003, 40)
Show SMILES Cn1ccnc1CN1Cc2cc3OC(COc3cc2C[C@H]1C(=O)N[C@@H](Cc1ccc(cc1)-c1ccc(cc1)C#N)C(O)=O)c1ccc(OCc2ccc(Cl)c(Cl)c2)cc1 |r|
Show InChI InChI=1S/C46H39Cl2N5O6/c1-52-17-16-50-44(52)25-53-24-35-22-42-41(58-27-43(59-42)33-11-13-36(14-12-33)57-26-30-6-15-37(47)38(48)18-30)21-34(35)20-40(53)45(54)51-39(46(55)56)19-28-2-7-31(8-3-28)32-9-4-29(23-49)5-10-32/h2-18,21-22,39-40,43H,19-20,24-27H2,1H3,(H,51,54)(H,55,56)/t39-,40-,43?/m0/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/an/an/a 310n/an/an/an/a



vTv Therapeutics LLC

US Patent


Assay Description
The efficacy of GLP-1 receptor agonists was studied in a cAMP functional assay using HEK-293 Cells expressing the cloned human GLP-1 receptor. GLP-1-...

US Patent US9175003 (2015)


BindingDB Entry DOI: 10.7270/Q27943FG
More data for this
Ligand-Target Pair
Glucagon-like peptide 1 receptor


(Homo sapiens (Human))		BDBM189949
PNG
(US9175003, 61)
Show SMILES CNc1nc(C)c(s1)S(=O)(=O)N1Cc2cc3O[C@@H](COc3cc2C[C@H]1C(=O)N[C@@H](Cc1ccc(cc1)-c1ccc(cc1)C#N)C(O)=O)c1ccc(OCc2ccc(Cl)c(Cl)c2)cc1 |r|
Show InChI InChI=1S/C46H39Cl2N5O8S2/c1-26-45(62-46(50-2)51-26)63(57,58)53-23-34-21-41-40(60-25-42(61-41)32-12-14-35(15-13-32)59-24-29-7-16-36(47)37(48)17-29)20-33(34)19-39(53)43(54)52-38(44(55)56)18-27-3-8-30(9-4-27)31-10-5-28(22-49)6-11-31/h3-17,20-21,38-39,42H,18-19,23-25H2,1-2H3,(H,50,51)(H,52,54)(H,55,56)/t38-,39-,42-/m0/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/an/an/a 73n/an/an/an/a



vTv Therapeutics LLC

US Patent


Assay Description
The efficacy of GLP-1 receptor agonists was studied in a cAMP functional assay using HEK-293 Cells expressing the cloned human GLP-1 receptor. GLP-1-...

US Patent US9175003 (2015)


BindingDB Entry DOI: 10.7270/Q27943FG
More data for this
Ligand-Target Pair
Glucagon-like peptide 1 receptor


(Homo sapiens (Human))		BDBM189964
PNG
(US9175003, 96)
Show SMILES CCNc1nc(c(C)s1)S(=O)(=O)N1Cc2cc3OC(COc3cc2C[C@H]1C(=O)N[C@@H](Cc1ccc(cc1)-c1ccc(cc1)C#N)C(O)=O)c1ccc(OCc2ccc(Cl)c(Cl)c2)cc1 |r|
Show InChI InChI=1S/C47H41Cl2N5O8S2/c1-3-51-47-53-45(27(2)63-47)64(58,59)54-24-35-22-42-41(61-26-43(62-42)33-13-15-36(16-14-33)60-25-30-8-17-37(48)38(49)18-30)21-34(35)20-40(54)44(55)52-39(46(56)57)19-28-4-9-31(10-5-28)32-11-6-29(23-50)7-12-32/h4-18,21-22,39-40,43H,3,19-20,24-26H2,1-2H3,(H,51,53)(H,52,55)(H,56,57)/t39-,40-,43?/m0/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/an/an/a 185n/an/an/an/a



vTv Therapeutics LLC

US Patent


Assay Description
The efficacy of GLP-1 receptor agonists was studied in a cAMP functional assay using HEK-293 Cells expressing the cloned human GLP-1 receptor. GLP-1-...

US Patent US9175003 (2015)


BindingDB Entry DOI: 10.7270/Q27943FG
More data for this
Ligand-Target Pair
Glucagon-like peptide 1 receptor


(Homo sapiens (Human))		BDBM189970
PNG
(US9175003, 111)
Show SMILES CC(=O)Nc1ccc(c(C)c1)S(=O)(=O)N1Cc2cc3OC(COc3cc2C[C@H]1C(=O)N[C@@H](Cc1ccc(cc1)-c1ccc(cc1)C#N)C(O)=O)c1ccc(OCc2ccc(Cl)c(Cl)c2)cc1 |r|
Show InChI InChI=1S/C50H42Cl2N4O9S/c1-29-19-39(54-30(2)57)14-18-48(29)66(61,62)56-26-38-24-46-45(64-28-47(65-46)36-12-15-40(16-13-36)63-27-33-7-17-41(51)42(52)20-33)23-37(38)22-44(56)49(58)55-43(50(59)60)21-31-3-8-34(9-4-31)35-10-5-32(25-53)6-11-35/h3-20,23-24,43-44,47H,21-22,26-28H2,1-2H3,(H,54,57)(H,55,58)(H,59,60)/t43-,44-,47?/m0/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/an/an/a 44n/an/an/an/a



vTv Therapeutics LLC

US Patent


Assay Description
The efficacy of GLP-1 receptor agonists was studied in a cAMP functional assay using HEK-293 Cells expressing the cloned human GLP-1 receptor. GLP-1-...

US Patent US9175003 (2015)


BindingDB Entry DOI: 10.7270/Q27943FG
More data for this
Ligand-Target Pair
Glucagon-like peptide 1 receptor


(Homo sapiens (Human))		BDBM189971
PNG
(US9175003, 112)
Show SMILES OC(=O)[C@H](Cc1ccc(cc1)-c1ccc(cc1)C#N)NC(=O)[C@@H]1Cc2cc3OCC(Oc3cc2CN1S(=O)(=O)c1ccc(nc1)N1CCOCC1)c1ccc(OCc2ccc(Cl)c(Cl)c2)cc1 |r|
Show InChI InChI=1S/C50H43Cl2N5O9S/c51-41-15-5-33(21-42(41)52)29-64-39-12-10-36(11-13-39)47-30-65-45-24-37-23-44(49(58)55-43(50(59)60)22-31-1-6-34(7-2-31)35-8-3-32(26-53)4-9-35)57(28-38(37)25-46(45)66-47)67(61,62)40-14-16-48(54-27-40)56-17-19-63-20-18-56/h1-16,21,24-25,27,43-44,47H,17-20,22-23,28-30H2,(H,55,58)(H,59,60)/t43-,44-,47?/m0/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/an/an/a 48n/an/an/an/a



vTv Therapeutics LLC

US Patent


Assay Description
The efficacy of GLP-1 receptor agonists was studied in a cAMP functional assay using HEK-293 Cells expressing the cloned human GLP-1 receptor. GLP-1-...

US Patent US9175003 (2015)


BindingDB Entry DOI: 10.7270/Q27943FG
More data for this
Ligand-Target Pair
Glucagon-like peptide 1 receptor


(Homo sapiens (Human))		BDBM189993
PNG
(US9175003, 152)
Show SMILES Cc1nccc(c1C)-c1ccc(C[C@H](NC(=O)[C@@H]2Cc3cc4OC[C@@H](Oc4cc3CN2C(=O)C(C)(C)C)c2ccc(OCc3ccc(Cl)c(Cl)c3)cc2)C(O)=O)cc1 |r|
Show InChI InChI=1S/C46H45Cl2N3O7/c1-26-27(2)49-17-16-35(26)30-9-6-28(7-10-30)19-38(44(53)54)50-43(52)39-20-32-21-40-41(22-33(32)23-51(39)45(55)46(3,4)5)58-42(25-57-40)31-11-13-34(14-12-31)56-24-29-8-15-36(47)37(48)18-29/h6-18,21-22,38-39,42H,19-20,23-25H2,1-5H3,(H,50,52)(H,53,54)/t38-,39-,42+/m0/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/an/an/a 80n/an/an/an/a



vTv Therapeutics LLC

US Patent


Assay Description
The efficacy of GLP-1 receptor agonists was studied in a cAMP functional assay using HEK-293 Cells expressing the cloned human GLP-1 receptor. GLP-1-...

US Patent US9175003 (2015)


BindingDB Entry DOI: 10.7270/Q27943FG
More data for this
Ligand-Target Pair
Glucagon-like peptide 1 receptor


(Homo sapiens (Human))		BDBM189999
PNG
(US9175003, 158)
Show SMILES Cc1ccc(cc1)C(=O)N1Cc2cc3O[C@H](COc3cc2C[C@H]1C(=O)N[C@@H](Cc1ccc(cc1)-c1ccnc(C)c1C)C(O)=O)c1ccc(OCc2ccc(Cl)c(Cl)c2)cc1 |r|
Show InChI InChI=1S/C49H43Cl2N3O7/c1-28-4-9-35(10-5-28)48(56)54-25-37-24-45-44(60-27-46(61-45)34-13-15-38(16-14-34)59-26-32-8-17-40(50)41(51)20-32)23-36(37)22-43(54)47(55)53-42(49(57)58)21-31-6-11-33(12-7-31)39-18-19-52-30(3)29(39)2/h4-20,23-24,42-43,46H,21-22,25-27H2,1-3H3,(H,53,55)(H,57,58)/t42-,43-,46+/m0/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/an/an/a 146n/an/an/an/a



vTv Therapeutics LLC

US Patent


Assay Description
The efficacy of GLP-1 receptor agonists was studied in a cAMP functional assay using HEK-293 Cells expressing the cloned human GLP-1 receptor. GLP-1-...

US Patent US9175003 (2015)


BindingDB Entry DOI: 10.7270/Q27943FG
More data for this
Ligand-Target Pair
Glucagon-like peptide 1 receptor


(Homo sapiens (Human))		BDBM190004
PNG
(US9175003, 163)
Show SMILES CC[C@H](N1Cc2cc3O[C@H](COc3cc2C[C@H]1C(=O)N[C@@H](Cc1ccc(cc1)-c1ccnc(C)c1C)C(O)=O)c1ccc(OCC2CCCCC2)cc1)c1ccccc1 |r|
Show InChI InChI=1S/C50H55N3O6/c1-4-44(37-13-9-6-10-14-37)53-29-40-28-47-46(58-31-48(59-47)38-19-21-41(22-20-38)57-30-35-11-7-5-8-12-35)27-39(40)26-45(53)49(54)52-43(50(55)56)25-34-15-17-36(18-16-34)42-23-24-51-33(3)32(42)2/h6,9-10,13-24,27-28,35,43-45,48H,4-5,7-8,11-12,25-26,29-31H2,1-3H3,(H,52,54)(H,55,56)/t43-,44-,45-,48+/m0/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/an/an/a 113n/an/an/an/a



vTv Therapeutics LLC

US Patent


Assay Description
The efficacy of GLP-1 receptor agonists was studied in a cAMP functional assay using HEK-293 Cells expressing the cloned human GLP-1 receptor. GLP-1-...

US Patent US9175003 (2015)


BindingDB Entry DOI: 10.7270/Q27943FG
More data for this
Ligand-Target Pair
Glucagon-like peptide 1 receptor


(Homo sapiens (Human))		BDBM189989
PNG
(US9175003, 148 | US9175003, 179)
Show SMILES CC[C@H](N1Cc2cc3O[C@H](COc3cc2C[C@H]1C(=O)N[C@@H](Cc1ccc(cc1)-c1ccnc(C)c1C)C(O)=O)c1ccc(OCc2ccc(Cl)c(Cl)c2)cc1)c1ccccc1 |r|
Show InChI InChI=1S/C50H47Cl2N3O6/c1-4-44(35-8-6-5-7-9-35)55-27-38-26-47-46(60-29-48(61-47)36-15-17-39(18-16-36)59-28-33-12-19-41(51)42(52)22-33)25-37(38)24-45(55)49(56)54-43(50(57)58)23-32-10-13-34(14-11-32)40-20-21-53-31(3)30(40)2/h5-22,25-26,43-45,48H,4,23-24,27-29H2,1-3H3,(H,54,56)(H,57,58)/t43-,44-,45-,48+/m0/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
Purchase

MCE
PC cid
PC sid
PDB
UniChem

Similars
US Patent
n/an/an/an/a 5n/an/an/an/a



vTv Therapeutics LLC

US Patent


Assay Description
The efficacy of GLP-1 receptor agonists was studied in a cAMP functional assay using HEK-293 Cells expressing the cloned human GLP-1 receptor. GLP-1-...

US Patent US9175003 (2015)


BindingDB Entry DOI: 10.7270/Q27943FG
More data for this
Ligand-Target Pair
Glucagon-like peptide 1 receptor


(Homo sapiens (Human))		BDBM190026
PNG
(US9175003, 186)
Show SMILES CC[C@H](N1Cc2cc3O[C@H](COc3cc2C[C@H]1C(=O)N[C@@H](Cc1ccc(cc1)-c1ccnnc1)C(O)=O)c1ccc(OCc2ccc(Cl)c(Cl)c2)cc1)c1ccccc1 |r|
Show InChI InChI=1S/C47H42Cl2N4O6/c1-2-41(32-6-4-3-5-7-32)53-26-36-24-44-43(58-28-45(59-44)33-13-15-37(16-14-33)57-27-30-10-17-38(48)39(49)20-30)23-35(36)22-42(53)46(54)52-40(47(55)56)21-29-8-11-31(12-9-29)34-18-19-50-51-25-34/h3-20,23-25,40-42,45H,2,21-22,26-28H2,1H3,(H,52,54)(H,55,56)/t40-,41-,42-,45+/m0/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/an/an/a 256n/an/an/an/a



vTv Therapeutics LLC

US Patent


Assay Description
The efficacy of GLP-1 receptor agonists was studied in a cAMP functional assay using HEK-293 Cells expressing the cloned human GLP-1 receptor. GLP-1-...

US Patent US9175003 (2015)


BindingDB Entry DOI: 10.7270/Q27943FG
More data for this
Ligand-Target Pair
Glucagon-like peptide 1 receptor


(Homo sapiens (Human))		BDBM190047
PNG
(US9175003, 225)
Show SMILES Cc1nc(C(=O)N2Cc3cc4O[C@H](COc4cc3C[C@H]2C(=O)N[C@@H](Cc2ccc(cc2)-c2ccnc(C)c2C)C(O)=O)c2ccc(OCC3CCC(CC3)C(F)(F)F)cc2)c(C)o1 |r,wU:19.22,12.46,wD:23.25,(6.87,-6.78,;6.1,-5.45,;6.58,-3.99,;5.33,-3.08,;5.33,-1.54,;6.67,-.77,;4,-.77,;2.67,-1.54,;1.33,-.77,;,-1.54,;-1.33,-.77,;-2.67,-1.54,;-4,-.77,;-4,.77,;-2.67,1.54,;-1.33,.77,;,1.54,;1.33,.77,;2.67,1.54,;4,.77,;5.33,1.54,;5.33,3.08,;6.67,.77,;8,1.54,;9.34,.77,;10.67,1.54,;12,.77,;13.34,1.54,;13.34,3.08,;12,3.85,;10.67,3.08,;14.67,3.85,;16,3.08,;17.34,3.85,;17.34,5.39,;16,6.16,;16,7.7,;14.67,5.39,;13.34,6.16,;8,3.08,;6.67,3.85,;9.34,3.85,;-5.33,-1.54,;-6.67,-.77,;-8,-1.54,;-8,-3.08,;-9.34,-3.85,;-10.67,-3.08,;-12,-3.85,;-13.34,-3.08,;-14.67,-3.85,;-14.67,-5.39,;-13.34,-6.16,;-12,-5.39,;-16,-6.16,;-17.34,-5.39,;-16,-7.7,;-16.4,-4.67,;-6.67,-3.85,;-5.33,-3.08,;4.09,-3.99,;2.76,-3.22,;4.56,-5.45,)|
Show InChI InChI=1S/C48H49F3N4O8/c1-26-27(2)52-18-17-38(26)32-9-5-30(6-10-32)19-39(47(58)59)54-45(56)40-20-34-21-41-42(22-35(34)23-55(40)46(57)44-28(3)62-29(4)53-44)63-43(25-61-41)33-11-15-37(16-12-33)60-24-31-7-13-36(14-8-31)48(49,50)51/h5-6,9-12,15-18,21-22,31,36,39-40,43H,7-8,13-14,19-20,23-25H2,1-4H3,(H,54,56)(H,58,59)/t31?,36?,39-,40-,43+/m0/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/an/an/a 183n/an/an/an/a



vTv Therapeutics LLC

US Patent


Assay Description
The efficacy of GLP-1 receptor agonists was studied in a cAMP functional assay using HEK-293 Cells expressing the cloned human GLP-1 receptor. GLP-1-...

US Patent US9175003 (2015)


BindingDB Entry DOI: 10.7270/Q27943FG
More data for this
Ligand-Target Pair
Glucagon-like peptide 1 receptor


(Homo sapiens (Human))		BDBM190050
PNG
(US9175003, 230)
Show SMILES Cc1nccc(c1C)-c1ccc(C[C@H](NC(=O)[C@@H]2Cc3cc4OC[C@@H](Oc4cc3CN2Cc2nccn2C)c2ccc(OCc3ccc(Cl)c(Cl)c3)cc2)C(O)=O)cc1 |r|
Show InChI InChI=1S/C46H43Cl2N5O6/c1-27-28(2)49-15-14-36(27)31-7-4-29(5-8-31)19-39(46(55)56)51-45(54)40-20-33-21-41-42(22-34(33)23-53(40)24-44-50-16-17-52(44)3)59-43(26-58-41)32-9-11-35(12-10-32)57-25-30-6-13-37(47)38(48)18-30/h4-18,21-22,39-40,43H,19-20,23-26H2,1-3H3,(H,51,54)(H,55,56)/t39-,40-,43+/m0/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/an/an/a 18n/an/an/an/a



vTv Therapeutics LLC

US Patent


Assay Description
The efficacy of GLP-1 receptor agonists was studied in a cAMP functional assay using HEK-293 Cells expressing the cloned human GLP-1 receptor. GLP-1-...

US Patent US9175003 (2015)


BindingDB Entry DOI: 10.7270/Q27943FG
More data for this
Ligand-Target Pair
Glucagon-like peptide 1 receptor


(Homo sapiens (Human))		BDBM190053
PNG
(US9175003, 235)
Show SMILES Cc1nccc(c1C)-c1ccc(C[C@H](NC(=O)[C@@H]2Cc3cc4OC[C@@H](Oc4cc3CN2C(=O)c2cnccn2)c2ccc(OCc3ccc(Cl)c(Cl)c3)cc2)C(O)=O)cc1 |r|
Show InChI InChI=1S/C46H39Cl2N5O7/c1-26-27(2)50-14-13-35(26)30-6-3-28(4-7-30)18-38(46(56)57)52-44(54)40-19-32-20-41-42(21-33(32)23-53(40)45(55)39-22-49-15-16-51-39)60-43(25-59-41)31-8-10-34(11-9-31)58-24-29-5-12-36(47)37(48)17-29/h3-17,20-22,38,40,43H,18-19,23-25H2,1-2H3,(H,52,54)(H,56,57)/t38-,40-,43+/m0/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/an/an/a 166n/an/an/an/a



vTv Therapeutics LLC

US Patent


Assay Description
The efficacy of GLP-1 receptor agonists was studied in a cAMP functional assay using HEK-293 Cells expressing the cloned human GLP-1 receptor. GLP-1-...

US Patent US9175003 (2015)


BindingDB Entry DOI: 10.7270/Q27943FG
More data for this
Ligand-Target Pair
Glucagon-like peptide 1 receptor


(Homo sapiens (Human))		BDBM190057
PNG
(US9175003, 239)
Show SMILES C[C@H](NC(=O)N1Cc2cc3O[C@H](COc3cc2C[C@H]1C(=O)N[C@@H](Cc1ccc(cc1)-c1ccnc(C)c1C)C(O)=O)c1ccc(OCc2ccc(Cl)c(Cl)c2)cc1)c1ccccc1 |r|
Show InChI InChI=1S/C50H46Cl2N4O7/c1-29-30(2)53-20-19-40(29)35-12-9-32(10-13-35)22-43(49(58)59)55-48(57)44-23-37-24-45-46(25-38(37)26-56(44)50(60)54-31(3)34-7-5-4-6-8-34)63-47(28-62-45)36-14-16-39(17-15-36)61-27-33-11-18-41(51)42(52)21-33/h4-21,24-25,31,43-44,47H,22-23,26-28H2,1-3H3,(H,54,60)(H,55,57)(H,58,59)/t31-,43-,44-,47+/m0/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/an/an/a 82n/an/an/an/a



vTv Therapeutics LLC

US Patent


Assay Description
The efficacy of GLP-1 receptor agonists was studied in a cAMP functional assay using HEK-293 Cells expressing the cloned human GLP-1 receptor. GLP-1-...

US Patent US9175003 (2015)


BindingDB Entry DOI: 10.7270/Q27943FG
More data for this
Ligand-Target Pair
Glucagon-like peptide 1 receptor


(Homo sapiens (Human))		BDBM190070
PNG
(US9175003, 255)
Show SMILES Cc1nccc(c1C)-c1ccc(C[C@H](NC(=O)[C@@H]2Cc3cc4OC[C@@H](Oc4cc3CN2C(=O)Nc2cc(F)cc(F)c2)c2ccc(OCc3ccc(Cl)c(Cl)c3)cc2)C(O)=O)cc1 |r|
Show InChI InChI=1S/C48H40Cl2F2N4O7/c1-26-27(2)53-14-13-38(26)30-6-3-28(4-7-30)16-41(47(58)59)55-46(57)42-17-32-18-43-44(19-33(32)23-56(42)48(60)54-36-21-34(51)20-35(52)22-36)63-45(25-62-43)31-8-10-37(11-9-31)61-24-29-5-12-39(49)40(50)15-29/h3-15,18-22,41-42,45H,16-17,23-25H2,1-2H3,(H,54,60)(H,55,57)(H,58,59)/t41-,42-,45+/m0/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/an/an/a 317n/an/an/an/a



vTv Therapeutics LLC

US Patent


Assay Description
The efficacy of GLP-1 receptor agonists was studied in a cAMP functional assay using HEK-293 Cells expressing the cloned human GLP-1 receptor. GLP-1-...

US Patent US9175003 (2015)


BindingDB Entry DOI: 10.7270/Q27943FG
More data for this
Ligand-Target Pair
Glucagon-like peptide 1 receptor


(Homo sapiens (Human))		BDBM190084
PNG
(US9175003, 281)
Show SMILES Cc1nccc(c1C)-c1ccc(C[C@H](NC(=O)[C@@H]2Cc3cc4OC[C@@H](Oc4cc3CN2C(=O)[C@@H]2CCN(C2)C(=O)OC(C)(C)C)c2ccc(OCc3ccc(Cl)c(Cl)c3)cc2)C(O)=O)cc1 |r|
Show InChI InChI=1S/C51H52Cl2N4O9/c1-29-30(2)54-18-16-39(29)33-9-6-31(7-10-33)21-42(49(60)61)55-47(58)43-22-36-23-44-45(24-37(36)26-57(43)48(59)35-17-19-56(25-35)50(62)66-51(3,4)5)65-46(28-64-44)34-11-13-38(14-12-34)63-27-32-8-15-40(52)41(53)20-32/h6-16,18,20,23-24,35,42-43,46H,17,19,21-22,25-28H2,1-5H3,(H,55,58)(H,60,61)/t35-,42+,43+,46-/m1/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/an/an/a 5n/an/an/an/a



vTv Therapeutics LLC

US Patent


Assay Description
The efficacy of GLP-1 receptor agonists was studied in a cAMP functional assay using HEK-293 Cells expressing the cloned human GLP-1 receptor. GLP-1-...

US Patent US9175003 (2015)


BindingDB Entry DOI: 10.7270/Q27943FG
More data for this
Ligand-Target Pair
Glucagon-like peptide 1 receptor


(Homo sapiens (Human))		BDBM190090
PNG
(US9175003, 297)
Show SMILES Cc1nccc(c1C)-c1ccc(C[C@H](NC(=O)[C@@H]2Cc3cc4OC[C@@H](Oc4cc3CN2C(=O)OCc2ccccc2)c2ccc(OCc3ccc(Cl)c(Cl)c3)cc2)C(O)=O)cc1 |r|
Show InChI InChI=1S/C49H43Cl2N3O8/c1-29-30(2)52-19-18-39(29)34-11-8-31(9-12-34)21-42(48(56)57)53-47(55)43-22-36-23-44-45(24-37(36)25-54(43)49(58)61-26-32-6-4-3-5-7-32)62-46(28-60-44)35-13-15-38(16-14-35)59-27-33-10-17-40(50)41(51)20-33/h3-20,23-24,42-43,46H,21-22,25-28H2,1-2H3,(H,53,55)(H,56,57)/t42-,43-,46+/m0/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/an/an/a 23n/an/an/an/a



vTv Therapeutics LLC

US Patent


Assay Description
The efficacy of GLP-1 receptor agonists was studied in a cAMP functional assay using HEK-293 Cells expressing the cloned human GLP-1 receptor. GLP-1-...

US Patent US9175003 (2015)


BindingDB Entry DOI: 10.7270/Q27943FG
More data for this
Ligand-Target Pair
Glucagon-like peptide 1 receptor


(Homo sapiens (Human))		BDBM190124
PNG
(US9175003, 356)
Show SMILES Cc1nc(C(=O)N2Cc3cc4O[C@H](COc4cc3C[C@H]2C(=O)N[C@@H](Cc2ccc(cc2)-c2ccnc(C)c2C)C(O)=O)c2ccc(OCc3cc(F)ccc3F)cc2)c(C)o1 |r|
Show InChI InChI=1S/C47H42F2N4O8/c1-25-26(2)50-16-15-37(25)30-7-5-29(6-8-30)17-39(47(56)57)52-45(54)40-19-32-20-41-42(21-33(32)22-53(40)46(55)44-27(3)60-28(4)51-44)61-43(24-59-41)31-9-12-36(13-10-31)58-23-34-18-35(48)11-14-38(34)49/h5-16,18,20-21,39-40,43H,17,19,22-24H2,1-4H3,(H,52,54)(H,56,57)/t39-,40-,43+/m0/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/an/an/a 57n/an/an/an/a



vTv Therapeutics LLC

US Patent


Assay Description
The efficacy of GLP-1 receptor agonists was studied in a cAMP functional assay using HEK-293 Cells expressing the cloned human GLP-1 receptor. GLP-1-...

US Patent US9175003 (2015)


BindingDB Entry DOI: 10.7270/Q27943FG
More data for this
Ligand-Target Pair
Glucagon-like peptide 1 receptor


(Homo sapiens (Human))		BDBM190126
PNG
(US9175003, 359)
Show SMILES Cc1nc(C(=O)N2Cc3cc4O[C@H](COc4cc3C[C@H]2C(=O)N[C@@H](Cc2ccc(cc2)-c2ccnc(C)c2C)C(O)=O)c2ccc(OCc3cccc(Cl)c3F)cc2)c(C)o1 |r|
Show InChI InChI=1S/C47H42ClFN4O8/c1-25-26(2)50-17-16-36(25)30-10-8-29(9-11-30)18-38(47(56)57)52-45(54)39-19-33-20-40-41(21-34(33)22-53(39)46(55)44-27(3)60-28(4)51-44)61-42(24-59-40)31-12-14-35(15-13-31)58-23-32-6-5-7-37(48)43(32)49/h5-17,20-21,38-39,42H,18-19,22-24H2,1-4H3,(H,52,54)(H,56,57)/t38-,39-,42+/m0/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/an/an/a 117n/an/an/an/a



vTv Therapeutics LLC

US Patent


Assay Description
The efficacy of GLP-1 receptor agonists was studied in a cAMP functional assay using HEK-293 Cells expressing the cloned human GLP-1 receptor. GLP-1-...

US Patent US9175003 (2015)


BindingDB Entry DOI: 10.7270/Q27943FG
More data for this
Ligand-Target Pair
Glucagon-like peptide 1 receptor


(Homo sapiens (Human))		BDBM190130
PNG
(US9175003, 365)
Show SMILES C[C@@H](NC(=O)N1Cc2cc3O[C@H](COc3cc2C[C@H]1C(=O)N[C@@H](Cc1ccc(cc1)-c1ccnc(C)c1C)C(O)=O)c1ccc(OCc2cc(F)cc(F)c2)cc1)c1ccccc1 |r|
Show InChI InChI=1S/C50H46F2N4O7/c1-29-30(2)53-18-17-42(29)35-11-9-32(10-12-35)21-43(49(58)59)55-48(57)44-22-37-23-45-46(24-38(37)26-56(44)50(60)54-31(3)34-7-5-4-6-8-34)63-47(28-62-45)36-13-15-41(16-14-36)61-27-33-19-39(51)25-40(52)20-33/h4-20,23-25,31,43-44,47H,21-22,26-28H2,1-3H3,(H,54,60)(H,55,57)(H,58,59)/t31-,43+,44+,47-/m1/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/an/an/a 95n/an/an/an/a



vTv Therapeutics LLC

US Patent


Assay Description
The efficacy of GLP-1 receptor agonists was studied in a cAMP functional assay using HEK-293 Cells expressing the cloned human GLP-1 receptor. GLP-1-...

US Patent US9175003 (2015)


BindingDB Entry DOI: 10.7270/Q27943FG
More data for this
Ligand-Target Pair
Glucagon-like peptide 1 receptor


(Homo sapiens (Human))		BDBM190139
PNG
(US9175003, 378)
Show SMILES Cc1nc(C(=O)N2Cc3cc4O[C@H](COc4cc3C[C@H]2C(=O)N[C@@H](Cc2ccc(cc2)-c2ccnc(C)c2C)C(O)=O)c2ccc(OCC3(CC3)c3ccc(Cl)cc3)cc2)c(C)o1 |r|
Show InChI InChI=1S/C50H47ClN4O8/c1-28-29(2)52-20-17-40(28)33-7-5-32(6-8-33)21-41(49(58)59)54-47(56)42-22-35-23-43-44(24-36(35)25-55(42)48(57)46-30(3)62-31(4)53-46)63-45(26-60-43)34-9-15-39(16-10-34)61-27-50(18-19-50)37-11-13-38(51)14-12-37/h5-17,20,23-24,41-42,45H,18-19,21-22,25-27H2,1-4H3,(H,54,56)(H,58,59)/t41-,42-,45+/m0/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/an/an/a 282n/an/an/an/a



vTv Therapeutics LLC

US Patent


Assay Description
The efficacy of GLP-1 receptor agonists was studied in a cAMP functional assay using HEK-293 Cells expressing the cloned human GLP-1 receptor. GLP-1-...

US Patent US9175003 (2015)


BindingDB Entry DOI: 10.7270/Q27943FG
More data for this
Ligand-Target Pair
Glucagon-like peptide 1 receptor


(Homo sapiens (Human))		BDBM190151
PNG
(US9175003, 393)
Show SMILES C[C@@H](NC(=O)N1Cc2cc3O[C@H](COc3cc2C[C@H]1C(=O)N[C@@H](Cc1ccc(cc1)-c1ccnc(C)c1C)C(O)=O)c1ccc(OCc2cc(Cl)cc(Cl)c2)cc1)c1ccccc1 |r|
Show InChI InChI=1S/C50H46Cl2N4O7/c1-29-30(2)53-18-17-42(29)35-11-9-32(10-12-35)21-43(49(58)59)55-48(57)44-22-37-23-45-46(24-38(37)26-56(44)50(60)54-31(3)34-7-5-4-6-8-34)63-47(28-62-45)36-13-15-41(16-14-36)61-27-33-19-39(51)25-40(52)20-33/h4-20,23-25,31,43-44,47H,21-22,26-28H2,1-3H3,(H,54,60)(H,55,57)(H,58,59)/t31-,43+,44+,47-/m1/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/an/an/a 74n/an/an/an/a



vTv Therapeutics LLC

US Patent


Assay Description
The efficacy of GLP-1 receptor agonists was studied in a cAMP functional assay using HEK-293 Cells expressing the cloned human GLP-1 receptor. GLP-1-...

US Patent US9175003 (2015)


BindingDB Entry DOI: 10.7270/Q27943FG
More data for this
Ligand-Target Pair
Glucagon-like peptide 1 receptor


(Homo sapiens (Human))		BDBM190156
PNG
(US9175003, 410)
Show SMILES CC(=O)Nc1nc(C)c(s1)S(=O)(=O)N1Cc2cc3O[C@H](COc3cc2C[C@H]1C(=O)N[C@@H](Cc1ccc(cc1)-c1ccnc(C)c1C)C(O)=O)c1ccc(OCc2ccc(Cl)c(Cl)c2)cc1 |r|
Show InChI InChI=1S/C47H43Cl2N5O9S2/c1-25-26(2)50-16-15-36(25)31-8-5-29(6-9-31)18-39(45(57)58)53-44(56)40-19-33-20-41-42(21-34(33)22-54(40)65(59,60)46-27(3)51-47(64-46)52-28(4)55)63-43(24-62-41)32-10-12-35(13-11-32)61-23-30-7-14-37(48)38(49)17-30/h5-17,20-21,39-40,43H,18-19,22-24H2,1-4H3,(H,53,56)(H,57,58)(H,51,52,55)/t39-,40-,43+/m0/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/an/an/a 24n/an/an/an/a



vTv Therapeutics LLC

US Patent


Assay Description
The efficacy of GLP-1 receptor agonists was studied in a cAMP functional assay using HEK-293 Cells expressing the cloned human GLP-1 receptor. GLP-1-...

US Patent US9175003 (2015)


BindingDB Entry DOI: 10.7270/Q27943FG
More data for this
Ligand-Target Pair
Glucagon-like peptide 1 receptor


(Homo sapiens (Human))		BDBM190160
PNG
(US9175003, 414)
Show SMILES C[C@@H](NC(=O)N1Cc2cc3O[C@H](COc3cc2C[C@H]1C(=O)N[C@@H](Cc1ccc(cc1)-c1ccnc(C)c1C)C(O)=O)c1cccc(OCc2ccc(Cl)c(Cl)c2)c1)c1ccccc1 |r|
Show InChI InChI=1S/C50H46Cl2N4O7/c1-29-30(2)53-19-18-40(29)35-15-12-32(13-16-35)21-43(49(58)59)55-48(57)44-23-37-24-45-46(25-38(37)26-56(44)50(60)54-31(3)34-8-5-4-6-9-34)63-47(28-62-45)36-10-7-11-39(22-36)61-27-33-14-17-41(51)42(52)20-33/h4-20,22,24-25,31,43-44,47H,21,23,26-28H2,1-3H3,(H,54,60)(H,55,57)(H,58,59)/t31-,43+,44+,47-/m1/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/an/an/a 191n/an/an/an/a



vTv Therapeutics LLC

US Patent


Assay Description
The efficacy of GLP-1 receptor agonists was studied in a cAMP functional assay using HEK-293 Cells expressing the cloned human GLP-1 receptor. GLP-1-...

US Patent US9175003 (2015)


BindingDB Entry DOI: 10.7270/Q27943FG
More data for this
Ligand-Target Pair
Glucagon-like peptide 1 receptor


(Homo sapiens (Human))		BDBM190174
PNG
(US9175003, 440)
Show SMILES Cc1nc(C(=O)N2Cc3cc4O[C@H](COc4cc3C[C@H]2C(=O)N[C@@H](Cc2ccc(cc2)-c2ccc(F)cc2)C(O)=O)c2ccc(OCc3ccc(Cl)c(Cl)c3)cc2)c(C)o1 |r|
Show InChI InChI=1S/C46H38Cl2FN3O8/c1-25-43(50-26(2)59-25)45(54)52-22-33-21-41-40(58-24-42(60-41)31-10-14-35(15-11-31)57-23-28-5-16-36(47)37(48)17-28)20-32(33)19-39(52)44(53)51-38(46(55)56)18-27-3-6-29(7-4-27)30-8-12-34(49)13-9-30/h3-17,20-21,38-39,42H,18-19,22-24H2,1-2H3,(H,51,53)(H,55,56)/t38-,39-,42+/m0/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/an/an/a 387n/an/an/an/a



vTv Therapeutics LLC

US Patent


Assay Description
The efficacy of GLP-1 receptor agonists was studied in a cAMP functional assay using HEK-293 Cells expressing the cloned human GLP-1 receptor. GLP-1-...

US Patent US9175003 (2015)


BindingDB Entry DOI: 10.7270/Q27943FG
More data for this
Ligand-Target Pair
Glucagon-like peptide 1 receptor


(Homo sapiens (Human))		BDBM189948
PNG
(US9175003, 60)
Show SMILES Cc1nc(N)sc1S(=O)(=O)N1Cc2cc3O[C@@H](COc3cc2C[C@H]1C(=O)N[C@@H](Cc1ccc(cc1)-c1ccc(cc1)C#N)C(O)=O)c1ccc(OCc2ccc(Cl)c(Cl)c2)cc1 |r|
Show InChI InChI=1S/C45H37Cl2N5O8S2/c1-25-44(61-45(49)50-25)62(56,57)52-22-33-20-40-39(59-24-41(60-40)31-11-13-34(14-12-31)58-23-28-6-15-35(46)36(47)16-28)19-32(33)18-38(52)42(53)51-37(43(54)55)17-26-2-7-29(8-3-26)30-9-4-27(21-48)5-10-30/h2-16,19-20,37-38,41H,17-18,22-24H2,1H3,(H2,49,50)(H,51,53)(H,54,55)/t37-,38-,41-/m0/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/an/an/a 109n/an/an/an/a



vTv Therapeutics LLC

US Patent


Assay Description
The efficacy of GLP-1 receptor agonists was studied in a cAMP functional assay using HEK-293 Cells expressing the cloned human GLP-1 receptor. GLP-1-...

US Patent US9175003 (2015)


BindingDB Entry DOI: 10.7270/Q27943FG
More data for this
Ligand-Target Pair
Glucagon-like peptide 1 receptor


(Homo sapiens (Human))		BDBM189950
PNG
(US9175003, 62)
Show SMILES CCNc1nc(C)c(s1)S(=O)(=O)N1Cc2cc3O[C@@H](COc3cc2C[C@H]1C(=O)N[C@@H](Cc1ccc(cc1)-c1ccc(cc1)C#N)C(O)=O)c1ccc(OCc2ccc(Cl)c(Cl)c2)cc1 |r|
Show InChI InChI=1S/C47H41Cl2N5O8S2/c1-3-51-47-52-27(2)46(63-47)64(58,59)54-24-35-22-42-41(61-26-43(62-42)33-13-15-36(16-14-33)60-25-30-8-17-37(48)38(49)18-30)21-34(35)20-40(54)44(55)53-39(45(56)57)19-28-4-9-31(10-5-28)32-11-6-29(23-50)7-12-32/h4-18,21-22,39-40,43H,3,19-20,24-26H2,1-2H3,(H,51,52)(H,53,55)(H,56,57)/t39-,40-,43-/m0/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/an/an/a 328n/an/an/an/a



vTv Therapeutics LLC

US Patent


Assay Description
The efficacy of GLP-1 receptor agonists was studied in a cAMP functional assay using HEK-293 Cells expressing the cloned human GLP-1 receptor. GLP-1-...

US Patent US9175003 (2015)


BindingDB Entry DOI: 10.7270/Q27943FG
More data for this
Ligand-Target Pair
Glucagon-like peptide 1 receptor


(Homo sapiens (Human))		BDBM189952
PNG
(US9175003, 65)
Show SMILES Cc1nc(N)sc1S(=O)(=O)N1Cc2cc3OC(COc3cc2C[C@H]1C(=O)N[C@@H](Cc1ccc(cc1)-c1ccc(cc1)C#N)C(O)=O)c1ccc(OCc2ccc(C)c(Cl)c2)cc1 |r|
Show InChI InChI=1S/C46H40ClN5O8S2/c1-26-3-4-30(17-37(26)47)24-58-36-15-13-33(14-16-36)42-25-59-40-20-34-19-39(52(23-35(34)21-41(40)60-42)62(56,57)45-27(2)50-46(49)61-45)43(53)51-38(44(54)55)18-28-5-9-31(10-6-28)32-11-7-29(22-48)8-12-32/h3-17,20-21,38-39,42H,18-19,23-25H2,1-2H3,(H2,49,50)(H,51,53)(H,54,55)/t38-,39-,42?/m0/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/an/an/a 434n/an/an/an/a



vTv Therapeutics LLC

US Patent


Assay Description
The efficacy of GLP-1 receptor agonists was studied in a cAMP functional assay using HEK-293 Cells expressing the cloned human GLP-1 receptor. GLP-1-...

US Patent US9175003 (2015)


BindingDB Entry DOI: 10.7270/Q27943FG
More data for this
Ligand-Target Pair
Glucagon-like peptide 1 receptor


(Homo sapiens (Human))		BDBM189959
PNG
(US9175003, 86)
Show SMILES CCNc1nc(C)c(s1)S(=O)(=O)N1Cc2cc3O[C@H](COc3cc2C[C@H]1C(=O)N[C@@H](Cc1ccc(cc1)-c1ccc(cc1)C#N)C(O)=O)c1ccc(OCc2ccc(Cl)c(Cl)c2)cc1 |r|
Show InChI InChI=1S/C47H41Cl2N5O8S2/c1-3-51-47-52-27(2)46(63-47)64(58,59)54-24-35-22-42-41(61-26-43(62-42)33-13-15-36(16-14-33)60-25-30-8-17-37(48)38(49)18-30)21-34(35)20-40(54)44(55)53-39(45(56)57)19-28-4-9-31(10-5-28)32-11-6-29(23-50)7-12-32/h4-18,21-22,39-40,43H,3,19-20,24-26H2,1-2H3,(H,51,52)(H,53,55)(H,56,57)/t39-,40-,43+/m0/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/an/an/a 249n/an/an/an/a



vTv Therapeutics LLC

US Patent


Assay Description
The efficacy of GLP-1 receptor agonists was studied in a cAMP functional assay using HEK-293 Cells expressing the cloned human GLP-1 receptor. GLP-1-...

US Patent US9175003 (2015)


BindingDB Entry DOI: 10.7270/Q27943FG
More data for this
Ligand-Target Pair
Glucagon-like peptide 1 receptor


(Homo sapiens (Human))		BDBM189967
PNG
(US9175003, 108)
Show SMILES Cc1nc(NC2CCCC2)sc1S(=O)(=O)N1Cc2cc3OC(COc3cc2C[C@H]1C(=O)N[C@@H](Cc1ccc(cc1)-c1ccc(cc1)C#N)C(O)=O)c1ccc(OCc2ccc(Cl)c(Cl)c2)cc1 |r|
Show InChI InChI=1S/C50H45Cl2N5O8S2/c1-29-49(66-50(54-29)55-38-4-2-3-5-38)67(61,62)57-26-37-24-45-44(64-28-46(65-45)35-15-17-39(18-16-35)63-27-32-10-19-40(51)41(52)20-32)23-36(37)22-43(57)47(58)56-42(48(59)60)21-30-6-11-33(12-7-30)34-13-8-31(25-53)9-14-34/h6-20,23-24,38,42-43,46H,2-5,21-22,26-28H2,1H3,(H,54,55)(H,56,58)(H,59,60)/t42-,43-,46?/m0/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/an/an/a 70n/an/an/an/a



vTv Therapeutics LLC

US Patent


Assay Description
The efficacy of GLP-1 receptor agonists was studied in a cAMP functional assay using HEK-293 Cells expressing the cloned human GLP-1 receptor. GLP-1-...

US Patent US9175003 (2015)


BindingDB Entry DOI: 10.7270/Q27943FG
More data for this
Ligand-Target Pair
Glucagon-like peptide 1 receptor


(Homo sapiens (Human))		BDBM189974
PNG
(US9175003, 119)
Show SMILES CCNc1nc(C)c(s1)S(=O)(=O)N1Cc2cc3OC(COc3cc2C[C@H]1C(=O)N[C@@H](Cc1ccc(cc1)-c1ccc(F)cc1)C(O)=O)c1ccc(OCc2ccc(Cl)c(Cl)c2)cc1 |r|
Show InChI InChI=1S/C46H41Cl2FN4O8S2/c1-3-50-46-51-26(2)45(62-46)63(57,58)53-23-33-22-41-40(60-25-42(61-41)31-11-15-35(16-12-31)59-24-28-6-17-36(47)37(48)18-28)21-32(33)20-39(53)43(54)52-38(44(55)56)19-27-4-7-29(8-5-27)30-9-13-34(49)14-10-30/h4-18,21-22,38-39,42H,3,19-20,23-25H2,1-2H3,(H,50,51)(H,52,54)(H,55,56)/t38-,39-,42?/m0/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/an/an/a 131n/an/an/an/a



vTv Therapeutics LLC

US Patent


Assay Description
The efficacy of GLP-1 receptor agonists was studied in a cAMP functional assay using HEK-293 Cells expressing the cloned human GLP-1 receptor. GLP-1-...

US Patent US9175003 (2015)


BindingDB Entry DOI: 10.7270/Q27943FG
More data for this
Ligand-Target Pair
Glucagon-like peptide 1 receptor


(Homo sapiens (Human))		BDBM189982
PNG
(US9175003, 136)
Show SMILES COCCNc1ccc(c(C)n1)S(=O)(=O)N1Cc2cc3OC(COc3cc2C[C@H]1C(=O)N[C@@H](Cc1ccc(cc1)-c1ccc(cc1)C#N)C(O)=O)c1ccc(OCc2ccc(Cl)c(Cl)c2)cc1 |r|
Show InChI InChI=1S/C50H45Cl2N5O9S/c1-30-47(17-18-48(55-30)54-19-20-63-2)67(61,62)57-27-38-25-45-44(65-29-46(66-45)36-12-14-39(15-13-36)64-28-33-7-16-40(51)41(52)21-33)24-37(38)23-43(57)49(58)56-42(50(59)60)22-31-3-8-34(9-4-31)35-10-5-32(26-53)6-11-35/h3-18,21,24-25,42-43,46H,19-20,22-23,27-29H2,1-2H3,(H,54,55)(H,56,58)(H,59,60)/t42-,43-,46?/m0/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/an/an/a 50n/an/an/an/a



vTv Therapeutics LLC

US Patent


Assay Description
The efficacy of GLP-1 receptor agonists was studied in a cAMP functional assay using HEK-293 Cells expressing the cloned human GLP-1 receptor. GLP-1-...

US Patent US9175003 (2015)


BindingDB Entry DOI: 10.7270/Q27943FG
More data for this
Ligand-Target Pair
Glucagon-like peptide 1 receptor


(Homo sapiens (Human))		BDBM189991
PNG
(US9175003, 150)
Show SMILES CC(=O)N1Cc2cc3O[C@H](COc3cc2C[C@H]1C(=O)N[C@@H](Cc1ccc(cc1)-c1ccnc(C)c1C)C(O)=O)c1ccc(OCc2ccc(Cl)c(Cl)c2)cc1 |r|
Show InChI InChI=1S/C43H39Cl2N3O7/c1-24-25(2)46-15-14-34(24)29-7-4-27(5-8-29)17-37(43(51)52)47-42(50)38-18-31-19-39-40(20-32(31)21-48(38)26(3)49)55-41(23-54-39)30-9-11-33(12-10-30)53-22-28-6-13-35(44)36(45)16-28/h4-16,19-20,37-38,41H,17-18,21-23H2,1-3H3,(H,47,50)(H,51,52)/t37-,38-,41+/m0/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/an/an/a 372n/an/an/an/a



vTv Therapeutics LLC

US Patent


Assay Description
The efficacy of GLP-1 receptor agonists was studied in a cAMP functional assay using HEK-293 Cells expressing the cloned human GLP-1 receptor. GLP-1-...

US Patent US9175003 (2015)


BindingDB Entry DOI: 10.7270/Q27943FG
More data for this
Ligand-Target Pair
Glucagon-like peptide 1 receptor


(Homo sapiens (Human))		BDBM189995
PNG
(US9175003, 154)
Show SMILES Cc1nccc(c1C)-c1ccc(C[C@H](NC(=O)[C@@H]2Cc3cc4OC[C@@H](Oc4cc3CN2C(=O)C2CCCC2)c2ccc(OCc3ccc(Cl)c(Cl)c3)cc2)C(O)=O)cc1 |r|
Show InChI InChI=1S/C47H45Cl2N3O7/c1-27-28(2)50-18-17-37(27)31-10-7-29(8-11-31)20-40(47(55)56)51-45(53)41-21-34-22-42-43(23-35(34)24-52(41)46(54)33-5-3-4-6-33)59-44(26-58-42)32-12-14-36(15-13-32)57-25-30-9-16-38(48)39(49)19-30/h7-19,22-23,33,40-41,44H,3-6,20-21,24-26H2,1-2H3,(H,51,53)(H,55,56)/t40-,41-,44+/m0/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/an/an/a 108n/an/an/an/a



vTv Therapeutics LLC

US Patent


Assay Description
The efficacy of GLP-1 receptor agonists was studied in a cAMP functional assay using HEK-293 Cells expressing the cloned human GLP-1 receptor. GLP-1-...

US Patent US9175003 (2015)


BindingDB Entry DOI: 10.7270/Q27943FG
More data for this
Ligand-Target Pair
Glucagon-like peptide 1 receptor


(Homo sapiens (Human))		BDBM189996
PNG
(US9175003, 155)
Show SMILES Cc1nccc(c1C)-c1ccc(C[C@H](NC(=O)[C@@H]2Cc3cc4OC[C@@H](Oc4cc3CN2C(=O)Cc2ccccc2)c2ccc(OCc3ccc(Cl)c(Cl)c3)cc2)C(O)=O)cc1 |r|
Show InChI InChI=1S/C49H43Cl2N3O7/c1-29-30(2)52-19-18-39(29)34-11-8-32(9-12-34)21-42(49(57)58)53-48(56)43-23-36-24-44-45(25-37(36)26-54(43)47(55)22-31-6-4-3-5-7-31)61-46(28-60-44)35-13-15-38(16-14-35)59-27-33-10-17-40(50)41(51)20-33/h3-20,24-25,42-43,46H,21-23,26-28H2,1-2H3,(H,53,56)(H,57,58)/t42-,43-,46+/m0/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/an/an/a 525n/an/an/an/a



vTv Therapeutics LLC

US Patent


Assay Description
The efficacy of GLP-1 receptor agonists was studied in a cAMP functional assay using HEK-293 Cells expressing the cloned human GLP-1 receptor. GLP-1-...

US Patent US9175003 (2015)


BindingDB Entry DOI: 10.7270/Q27943FG
More data for this
Ligand-Target Pair
Glucagon-like peptide 1 receptor


(Homo sapiens (Human))		BDBM190007
PNG
(US9175003, 166)
Show SMILES CCC(CC)Oc1ccc(cc1)[C@H]1COc2cc3C[C@H](N(Cc3cc2O1)[C@@H](CC)c1ccccc1)C(=O)N[C@@H](Cc1ccc(cc1)-c1ccnc(C)c1C)C(O)=O |r|
Show InChI InChI=1S/C48H53N3O6/c1-6-38(7-2)56-39-20-18-35(19-21-39)46-29-55-44-26-36-25-43(51(28-37(36)27-45(44)57-46)42(8-3)34-12-10-9-11-13-34)47(52)50-41(48(53)54)24-32-14-16-33(17-15-32)40-22-23-49-31(5)30(40)4/h9-23,26-27,38,41-43,46H,6-8,24-25,28-29H2,1-5H3,(H,50,52)(H,53,54)/t41-,42-,43-,46+/m0/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/an/an/a 22n/an/an/an/a



vTv Therapeutics LLC

US Patent


Assay Description
The efficacy of GLP-1 receptor agonists was studied in a cAMP functional assay using HEK-293 Cells expressing the cloned human GLP-1 receptor. GLP-1-...

US Patent US9175003 (2015)


BindingDB Entry DOI: 10.7270/Q27943FG
More data for this
Ligand-Target Pair
Glucagon-like peptide 1 receptor


(Homo sapiens (Human))		BDBM190022
PNG
(US9175003, 181)
Show SMILES CC[C@H](N1Cc2cc3O[C@H](COc3cc2C[C@H]1C(=O)N[C@@H](Cc1ccc(Oc2ccnc(C)c2)cc1)C(O)=O)c1ccc(OCc2ccc(Cl)c(Cl)c2)cc1)c1ccccc1 |r|
Show InChI InChI=1S/C49H45Cl2N3O7/c1-3-43(33-7-5-4-6-8-33)54-27-36-26-46-45(59-29-47(61-46)34-12-16-37(17-13-34)58-28-32-11-18-40(50)41(51)22-32)25-35(36)24-44(54)48(55)53-42(49(56)57)23-31-9-14-38(15-10-31)60-39-19-20-52-30(2)21-39/h4-22,25-26,42-44,47H,3,23-24,27-29H2,1-2H3,(H,53,55)(H,56,57)/t42-,43-,44-,47+/m0/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/an/an/a 16n/an/an/an/a



vTv Therapeutics LLC

US Patent


Assay Description
The efficacy of GLP-1 receptor agonists was studied in a cAMP functional assay using HEK-293 Cells expressing the cloned human GLP-1 receptor. GLP-1-...

US Patent US9175003 (2015)


BindingDB Entry DOI: 10.7270/Q27943FG
More data for this
Ligand-Target Pair
Glucagon-like peptide 1 receptor


(Homo sapiens (Human))		BDBM190024
PNG
(US9175003, 184)
Show SMILES CC[C@H](N1Cc2cc3O[C@H](COc3cc2C[C@H]1C(=O)N[C@@H](Cc1ccc(Oc2ccncc2)cc1)C(O)=O)c1ccc(OCc2ccc(Cl)c(Cl)c2)cc1)c1ccccc1 |r|
Show InChI InChI=1S/C48H43Cl2N3O7/c1-2-42(32-6-4-3-5-7-32)53-27-35-26-45-44(58-29-46(60-45)33-11-15-36(16-12-33)57-28-31-10-17-39(49)40(50)22-31)25-34(35)24-43(53)47(54)52-41(48(55)56)23-30-8-13-37(14-9-30)59-38-18-20-51-21-19-38/h3-22,25-26,41-43,46H,2,23-24,27-29H2,1H3,(H,52,54)(H,55,56)/t41-,42-,43-,46+/m0/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/an/an/a 74n/an/an/an/a



vTv Therapeutics LLC

US Patent


Assay Description
The efficacy of GLP-1 receptor agonists was studied in a cAMP functional assay using HEK-293 Cells expressing the cloned human GLP-1 receptor. GLP-1-...

US Patent US9175003 (2015)


BindingDB Entry DOI: 10.7270/Q27943FG
More data for this
Ligand-Target Pair
Glucagon-like peptide 1 receptor


(Homo sapiens (Human))		BDBM190025
PNG
(US9175003, 185)
Show SMILES CC[C@H](N1Cc2cc3O[C@H](COc3cc2C[C@H]1C(=O)N[C@@H](Cc1ccc(Oc2cccnc2)cc1)C(O)=O)c1ccc(OCc2ccc(Cl)c(Cl)c2)cc1)c1ccccc1 |r|
Show InChI InChI=1S/C48H43Cl2N3O7/c1-2-42(32-7-4-3-5-8-32)53-27-35-25-45-44(58-29-46(60-45)33-13-17-36(18-14-33)57-28-31-12-19-39(49)40(50)21-31)24-34(35)23-43(53)47(54)52-41(48(55)56)22-30-10-15-37(16-11-30)59-38-9-6-20-51-26-38/h3-21,24-26,41-43,46H,2,22-23,27-29H2,1H3,(H,52,54)(H,55,56)/t41-,42-,43-,46+/m0/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/an/an/a 119n/an/an/an/a



vTv Therapeutics LLC

US Patent


Assay Description
The efficacy of GLP-1 receptor agonists was studied in a cAMP functional assay using HEK-293 Cells expressing the cloned human GLP-1 receptor. GLP-1-...

US Patent US9175003 (2015)


BindingDB Entry DOI: 10.7270/Q27943FG
More data for this
Ligand-Target Pair
Glucagon-like peptide 1 receptor


(Homo sapiens (Human))		BDBM190082
PNG
(US9175003, 279)
Show SMILES Cc1nccc(c1C)-c1ccc(C[C@H](NC(=O)[C@@H]2Cc3cc4OC[C@@H](Oc4cc3CN2C(=O)[C@H]2CCCN2C(=O)OC(C)(C)C)c2ccc(OCc3ccc(Cl)c(Cl)c3)cc2)C(O)=O)cc1 |r|
Show InChI InChI=1S/C51H52Cl2N4O9/c1-29-30(2)54-19-18-38(29)33-11-8-31(9-12-33)22-41(49(60)61)55-47(58)43-23-35-24-44-45(25-36(35)26-57(43)48(59)42-7-6-20-56(42)50(62)66-51(3,4)5)65-46(28-64-44)34-13-15-37(16-14-34)63-27-32-10-17-39(52)40(53)21-32/h8-19,21,24-25,41-43,46H,6-7,20,22-23,26-28H2,1-5H3,(H,55,58)(H,60,61)/t41-,42+,43-,46+/m0/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/an/an/a 15n/an/an/an/a



vTv Therapeutics LLC

US Patent


Assay Description
The efficacy of GLP-1 receptor agonists was studied in a cAMP functional assay using HEK-293 Cells expressing the cloned human GLP-1 receptor. GLP-1-...

US Patent US9175003 (2015)


BindingDB Entry DOI: 10.7270/Q27943FG
More data for this
Ligand-Target Pair
Glucagon-like peptide 1 receptor


(Homo sapiens (Human))		BDBM190100
PNG
(US9175003, 314)
Show SMILES CC(C)N(C(C)C)C(=O)N1Cc2cc3O[C@H](COc3cc2C[C@H]1C(=O)N[C@@H](Cc1ccc(cc1)-c1ccnc(C)c1C)C(O)=O)c1ccc(OCc2ccc(Cl)c(Cl)c2)cc1 |r|
Show InChI InChI=1S/C48H50Cl2N4O7/c1-27(2)54(28(3)4)48(58)53-24-36-23-44-43(60-26-45(61-44)34-12-14-37(15-13-34)59-25-32-9-16-39(49)40(50)19-32)22-35(36)21-42(53)46(55)52-41(47(56)57)20-31-7-10-33(11-8-31)38-17-18-51-30(6)29(38)5/h7-19,22-23,27-28,41-42,45H,20-21,24-26H2,1-6H3,(H,52,55)(H,56,57)/t41-,42-,45+/m0/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/an/an/a 73n/an/an/an/a



vTv Therapeutics LLC

US Patent


Assay Description
The efficacy of GLP-1 receptor agonists was studied in a cAMP functional assay using HEK-293 Cells expressing the cloned human GLP-1 receptor. GLP-1-...

US Patent US9175003 (2015)


BindingDB Entry DOI: 10.7270/Q27943FG
More data for this
Ligand-Target Pair
Glucagon-like peptide 1 receptor


(Homo sapiens (Human))		BDBM190104
PNG
(US9175003, 324)
Show SMILES Cc1nccc(c1C)-c1ccc(C[C@H](NC(=O)[C@@H]2Cc3cc4OC[C@@H](Oc4cc3CN2C(=O)c2ccn(C)n2)c2ccc(OCc3ccc(Cl)c(Cl)c3)cc2)C(O)=O)cc1 |r|
Show InChI InChI=1S/C46H41Cl2N5O7/c1-26-27(2)49-16-14-35(26)30-7-4-28(5-8-30)19-39(46(56)57)50-44(54)40-20-32-21-41-42(22-33(32)23-53(40)45(55)38-15-17-52(3)51-38)60-43(25-59-41)31-9-11-34(12-10-31)58-24-29-6-13-36(47)37(48)18-29/h4-18,21-22,39-40,43H,19-20,23-25H2,1-3H3,(H,50,54)(H,56,57)/t39-,40-,43+/m0/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/an/an/a 126n/an/an/an/a



vTv Therapeutics LLC

US Patent


Assay Description
The efficacy of GLP-1 receptor agonists was studied in a cAMP functional assay using HEK-293 Cells expressing the cloned human GLP-1 receptor. GLP-1-...

US Patent US9175003 (2015)


BindingDB Entry DOI: 10.7270/Q27943FG
More data for this
Ligand-Target Pair
Glucagon-like peptide 1 receptor


(Homo sapiens (Human))		BDBM190106
PNG
(US9175003, 329)
Show SMILES Cc1ccc(s1)C(=O)N1Cc2cc3O[C@H](COc3cc2C[C@H]1C(=O)N[C@@H](Cc1ccc(cc1)-c1ccnc(C)c1C)C(O)=O)c1ccc(OCc2ccc(Cl)c(Cl)c2)cc1 |r|
Show InChI InChI=1S/C47H41Cl2N3O7S/c1-26-4-15-44(60-26)46(54)52-23-34-22-42-41(58-25-43(59-42)32-10-12-35(13-11-32)57-24-30-7-14-37(48)38(49)18-30)21-33(34)20-40(52)45(53)51-39(47(55)56)19-29-5-8-31(9-6-29)36-16-17-50-28(3)27(36)2/h4-18,21-22,39-40,43H,19-20,23-25H2,1-3H3,(H,51,53)(H,55,56)/t39-,40-,43+/m0/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/an/an/a 81n/an/an/an/a



vTv Therapeutics LLC

US Patent


Assay Description
The efficacy of GLP-1 receptor agonists was studied in a cAMP functional assay using HEK-293 Cells expressing the cloned human GLP-1 receptor. GLP-1-...

US Patent US9175003 (2015)


BindingDB Entry DOI: 10.7270/Q27943FG
More data for this
Ligand-Target Pair
Glucagon-like peptide 1 receptor


(Homo sapiens (Human))		BDBM190109
PNG
(US9175003, 335)
Show SMILES C[C@H](NC(=O)N1Cc2cc3O[C@H](COc3cc2C[C@H]1C(=O)N[C@@H](Cc1ccc(Oc2ccnc(C)c2C)cc1)C(O)=O)c1ccc(OCc2ccc(Cl)c(Cl)c2)cc1)c1ccccc1 |r|
Show InChI InChI=1S/C50H46Cl2N4O8/c1-29-30(2)53-20-19-44(29)63-39-14-9-32(10-15-39)22-42(49(58)59)55-48(57)43-23-36-24-45-46(25-37(36)26-56(43)50(60)54-31(3)34-7-5-4-6-8-34)64-47(28-62-45)35-12-16-38(17-13-35)61-27-33-11-18-40(51)41(52)21-33/h4-21,24-25,31,42-43,47H,22-23,26-28H2,1-3H3,(H,54,60)(H,55,57)(H,58,59)/t31-,42-,43-,47+/m0/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/an/an/a 115n/an/an/an/a



vTv Therapeutics LLC

US Patent


Assay Description
The efficacy of GLP-1 receptor agonists was studied in a cAMP functional assay using HEK-293 Cells expressing the cloned human GLP-1 receptor. GLP-1-...

US Patent US9175003 (2015)


BindingDB Entry DOI: 10.7270/Q27943FG
More data for this
Ligand-Target Pair
Glucagon-like peptide 1 receptor


(Homo sapiens (Human))		BDBM190112
PNG
(US9175003, 338)
Show SMILES Cc1ccccc1NC(=O)N1Cc2cc3O[C@H](COc3cc2C[C@H]1C(=O)N[C@@H](Cc1ccc(Oc2ccnc(C)c2C)cc1)C(O)=O)c1ccc(OCc2ccc(Cl)c(Cl)c2)cc1 |r|
Show InChI InChI=1S/C49H44Cl2N4O8/c1-28-6-4-5-7-40(28)54-49(59)55-25-35-24-45-44(61-27-46(63-45)33-11-15-36(16-12-33)60-26-32-10-17-38(50)39(51)20-32)23-34(35)22-42(55)47(56)53-41(48(57)58)21-31-8-13-37(14-9-31)62-43-18-19-52-30(3)29(43)2/h4-20,23-24,41-42,46H,21-22,25-27H2,1-3H3,(H,53,56)(H,54,59)(H,57,58)/t41-,42-,46+/m0/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/an/an/a 377n/an/an/an/a



vTv Therapeutics LLC

US Patent


Assay Description
The efficacy of GLP-1 receptor agonists was studied in a cAMP functional assay using HEK-293 Cells expressing the cloned human GLP-1 receptor. GLP-1-...

US Patent US9175003 (2015)


BindingDB Entry DOI: 10.7270/Q27943FG
More data for this
Ligand-Target Pair
Glucagon-like peptide 1 receptor


(Homo sapiens (Human))		BDBM190115
PNG
(US9175003, 344)
Show SMILES Cc1nccc(Oc2ccc(C[C@H](NC(=O)[C@@H]3Cc4cc5OC[C@@H](Oc5cc4CN3C(=O)NC3CCCCC3)c3ccc(OCc4ccc(Cl)c(Cl)c4)cc3)C(O)=O)cc2)c1C |r|
Show InChI InChI=1S/C48H48Cl2N4O8/c1-28-29(2)51-19-18-42(28)61-37-13-8-30(9-14-37)21-40(47(56)57)53-46(55)41-22-33-23-43-44(24-34(33)25-54(41)48(58)52-35-6-4-3-5-7-35)62-45(27-60-43)32-11-15-36(16-12-32)59-26-31-10-17-38(49)39(50)20-31/h8-20,23-24,35,40-41,45H,3-7,21-22,25-27H2,1-2H3,(H,52,58)(H,53,55)(H,56,57)/t40-,41-,45+/m0/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/an/an/a 271n/an/an/an/a



vTv Therapeutics LLC

US Patent


Assay Description
The efficacy of GLP-1 receptor agonists was studied in a cAMP functional assay using HEK-293 Cells expressing the cloned human GLP-1 receptor. GLP-1-...

US Patent US9175003 (2015)


BindingDB Entry DOI: 10.7270/Q27943FG
More data for this
Ligand-Target Pair
Glucagon-like peptide 1 receptor


(Homo sapiens (Human))		BDBM190117
PNG
(US9175003, 347)
Show SMILES Cc1nccc(Oc2ccc(C[C@H](NC(=O)[C@@H]3Cc4cc5OC[C@@H](Oc5cc4CN3C(=O)NC3CCC3)c3ccc(OCc4ccc(Cl)c(Cl)c4)cc3)C(O)=O)cc2)c1C |r|
Show InChI InChI=1S/C46H44Cl2N4O8/c1-26-27(2)49-17-16-40(26)59-35-11-6-28(7-12-35)19-38(45(54)55)51-44(53)39-20-31-21-41-42(22-32(31)23-52(39)46(56)50-33-4-3-5-33)60-43(25-58-41)30-9-13-34(14-10-30)57-24-29-8-15-36(47)37(48)18-29/h6-18,21-22,33,38-39,43H,3-5,19-20,23-25H2,1-2H3,(H,50,56)(H,51,53)(H,54,55)/t38-,39-,43+/m0/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/an/an/a 315n/an/an/an/a



vTv Therapeutics LLC

US Patent


Assay Description
The efficacy of GLP-1 receptor agonists was studied in a cAMP functional assay using HEK-293 Cells expressing the cloned human GLP-1 receptor. GLP-1-...

US Patent US9175003 (2015)


BindingDB Entry DOI: 10.7270/Q27943FG
More data for this
Ligand-Target Pair
Glucagon-like peptide 1 receptor


(Homo sapiens (Human))		BDBM190134
PNG
(US9175003, 372)
Show SMILES Cc1nc(C(=O)N2Cc3cc4O[C@H](COc4cc3C[C@H]2C(=O)N[C@@H](Cc2ccc(cc2)-c2ccnc(C)c2C)C(O)=O)c2ccc(O[C@H]3CC[C@@H](CC3)C(C)(C)C)cc2)c(C)o1 |r,wU:12.46,19.22,50.58,wD:47.51,23.25,(6.21,-7.24,;5.44,-5.91,;5.91,-4.44,;4.67,-3.54,;4.67,-2,;6,-1.23,;3.33,-1.23,;2,-2,;.67,-1.23,;-.67,-2,;-2,-1.23,;-3.33,-2,;-4.67,-1.23,;-4.67,.31,;-3.33,1.08,;-2,.31,;-.67,1.08,;.67,.31,;2,1.08,;3.33,.31,;4.67,1.08,;4.67,2.62,;6,.31,;7.34,1.08,;8.67,.31,;10,1.08,;11.34,.31,;12.67,1.08,;12.67,2.62,;11.34,3.39,;10,2.62,;14,3.39,;15.34,2.62,;16.67,3.39,;16.67,4.93,;15.34,5.7,;15.34,7.24,;14,4.93,;12.67,5.7,;7.34,2.62,;6,3.39,;8.67,3.39,;-6,-2,;-6,-3.54,;-7.34,-4.31,;-8.67,-3.54,;-10,-4.31,;-11.34,-3.54,;-11.34,-2,;-12.67,-1.23,;-14,-2,;-14,-3.54,;-12.67,-4.31,;-15.34,-1.23,;-16.67,-2,;-15.34,.31,;-14.25,-.14,;-8.67,-2,;-7.34,-1.23,;3.42,-4.44,;2.09,-3.67,;3.9,-5.91,)|
Show InChI InChI=1S/C50H56N4O8/c1-28-29(2)51-21-20-40(28)33-10-8-32(9-11-33)22-41(49(57)58)53-47(55)42-23-35-24-43-44(25-36(35)26-54(42)48(56)46-30(3)60-31(4)52-46)62-45(27-59-43)34-12-16-38(17-13-34)61-39-18-14-37(15-19-39)50(5,6)7/h8-13,16-17,20-21,24-25,37,39,41-42,45H,14-15,18-19,22-23,26-27H2,1-7H3,(H,53,55)(H,57,58)/t37-,39-,41-,42-,45+/m0/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/an/an/a 64n/an/an/an/a



vTv Therapeutics LLC

US Patent


Assay Description
The efficacy of GLP-1 receptor agonists was studied in a cAMP functional assay using HEK-293 Cells expressing the cloned human GLP-1 receptor. GLP-1-...

US Patent US9175003 (2015)


BindingDB Entry DOI: 10.7270/Q27943FG
More data for this
Ligand-Target Pair
Glucagon-like peptide 1 receptor


(Homo sapiens (Human))		BDBM190141
PNG
(US9175003, 380)
Show SMILES Cc1nc(C(=O)N2Cc3cc4O[C@H](COc4cc3C[C@H]2C(=O)N[C@@H](Cc2ccc(cc2)-c2ccnc(C)c2C)C(O)=O)c2ccc(OCCC(C)(C)C)cc2)c(C)o1 |r|
Show InChI InChI=1S/C46H50N4O8/c1-26-27(2)47-18-16-36(26)31-10-8-30(9-11-31)20-37(45(53)54)49-43(51)38-21-33-22-39-40(23-34(33)24-50(38)44(52)42-28(3)57-29(4)48-42)58-41(25-56-39)32-12-14-35(15-13-32)55-19-17-46(5,6)7/h8-16,18,22-23,37-38,41H,17,19-21,24-25H2,1-7H3,(H,49,51)(H,53,54)/t37-,38-,41+/m0/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/an/an/a 213n/an/an/an/a



vTv Therapeutics LLC

US Patent


Assay Description
The efficacy of GLP-1 receptor agonists was studied in a cAMP functional assay using HEK-293 Cells expressing the cloned human GLP-1 receptor. GLP-1-...

US Patent US9175003 (2015)


BindingDB Entry DOI: 10.7270/Q27943FG
More data for this
Ligand-Target Pair
Glucagon-like peptide 1 receptor


(Homo sapiens (Human))		BDBM190142
PNG
(US9175003, 381)
Show SMILES C[C@H]1CC[C@H](CC1)Oc1ccc(cc1)[C@H]1COc2cc3C[C@H](N(Cc3cc2O1)C(=O)c1nc(C)oc1C)C(=O)N[C@@H](Cc1ccc(cc1)-c1ccnc(C)c1C)C(O)=O |r,wU:4.7,14.15,21.42,1.0,wD:40.45,(-16.31,-5.62,;-14.82,-5.22,;-14.43,-3.73,;-12.94,-3.34,;-11.85,-4.43,;-12.25,-5.91,;-13.74,-6.31,;-10.36,-4.03,;-9.03,-3.26,;-7.69,-4.03,;-6.36,-3.26,;-6.36,-1.72,;-7.69,-.95,;-9.03,-1.72,;-5.03,-.95,;-5.03,.59,;-3.69,1.36,;-2.36,.59,;-1.03,1.36,;.31,.59,;1.64,1.36,;2.98,.59,;2.98,-.95,;1.64,-1.72,;.31,-.95,;-1.03,-1.72,;-2.36,-.95,;-3.69,-1.72,;3.75,-2.28,;5.29,-2.28,;2.98,-3.61,;3.45,-5.08,;2.21,-5.98,;2.21,-7.52,;.96,-5.08,;1.44,-3.61,;.67,-2.28,;4.31,1.36,;4.31,2.9,;5.64,.59,;6.98,1.36,;8.31,.59,;9.64,1.36,;10.98,.59,;12.31,1.36,;12.31,2.9,;10.98,3.67,;9.64,2.9,;13.64,3.67,;14.98,2.9,;16.31,3.67,;16.31,5.21,;14.98,5.98,;14.98,7.52,;13.64,5.21,;12.31,5.98,;6.98,2.9,;8.31,3.67,;5.64,3.67,)|
Show InChI InChI=1S/C47H50N4O8/c1-26-6-14-36(15-7-26)58-37-16-12-33(13-17-37)43-25-56-41-22-34-21-40(51(24-35(34)23-42(41)59-43)46(53)44-29(4)57-30(5)49-44)45(52)50-39(47(54)55)20-31-8-10-32(11-9-31)38-18-19-48-28(3)27(38)2/h8-13,16-19,22-23,26,36,39-40,43H,6-7,14-15,20-21,24-25H2,1-5H3,(H,50,52)(H,54,55)/t26-,36+,39-,40-,43+/m0/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/an/an/a 313n/an/an/an/a



vTv Therapeutics LLC

US Patent


Assay Description
The efficacy of GLP-1 receptor agonists was studied in a cAMP functional assay using HEK-293 Cells expressing the cloned human GLP-1 receptor. GLP-1-...

US Patent US9175003 (2015)


BindingDB Entry DOI: 10.7270/Q27943FG
More data for this
Ligand-Target Pair
Displayed 1 to 50 (of 234 total )  |  Next  |  Last  >>
* indicates data uncertainty>20%