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USPatent US9351965

Compile data set for download or QSAR
Found 152 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233415
PNG
(US9351965, 22)
Show SMILES COc1cccc(F)c1C[C@@]1(O)CCC[C@H](C1)NC(=O)c1ccc2[nH]nc(-c3ccnc(C)c3)c2c1 |r|
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US Patent
n/an/a 2n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


US Patent US9351965 (2016)


BindingDB Entry DOI: 10.7270/Q2GT5M11
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233416
PNG
(US9351965, 23)
Show SMILES COc1cccc(F)c1C[C@@]1(O)CCC[C@H](C1)NC(=O)c1ccc2[nH]nc(-c3ccc4nccn4c3)c2c1 |r|
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n/an/a 2.20n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


US Patent US9351965 (2016)


BindingDB Entry DOI: 10.7270/Q2GT5M11
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233459
PNG
(US9351965, 66)
Show SMILES Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)N[C@@H]1CCC[C@@](O)(Cn2ncc3ccccc23)C1 |r|
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n/an/a 7n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


US Patent US9351965 (2016)


BindingDB Entry DOI: 10.7270/Q2GT5M11
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233394
PNG
(US9351965, 1 | US9351965, 2 | US9351965, 3 | US935...)
Show SMILES Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)NC1CCCC(O)(Cc2ccccc2F)C1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


US Patent US9351965 (2016)


BindingDB Entry DOI: 10.7270/Q2GT5M11
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233472
PNG
(US9351965, 79)
Show SMILES Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)N[C@@H]1CCC[C@@](O)(Cn2ncc3cccnc23)C1 |r|
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


US Patent US9351965 (2016)


BindingDB Entry DOI: 10.7270/Q2GT5M11
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233408
PNG
(US9351965, 15)
Show SMILES O[C@]1(Cc2ccccc2F)CCC[C@H](C1)NC(=O)c1ccc2[nH]nc(-c3ccc4nccn4c3)c2c1 |r|
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


US Patent US9351965 (2016)


BindingDB Entry DOI: 10.7270/Q2GT5M11
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233417
PNG
(US9351965, 24)
Show SMILES COc1cccc(F)c1C[C@@]1(O)CCC[C@H](C1)NC(=O)c1ccc2[nH]nc(-c3ccc4nc(C)sc4c3)c2c1 |r|
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n/an/a 8.90n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


US Patent US9351965 (2016)


BindingDB Entry DOI: 10.7270/Q2GT5M11
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233516
PNG
(US9351965, 123)
Show SMILES Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)NC1CCCC(Cn2ncc3ccccc23)C1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


US Patent US9351965 (2016)


BindingDB Entry DOI: 10.7270/Q2GT5M11
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233485
PNG
(US9351965, 92)
Show SMILES Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)N[C@@H]1CCC[C@@](O)(CN2C(=O)Cc3ccccc23)C1 |r|
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


US Patent US9351965 (2016)


BindingDB Entry DOI: 10.7270/Q2GT5M11
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233435
PNG
(US9351965, 42)
Show SMILES Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)NC1CCCC(C1)(Oc1cccc(F)c1)C(N)=O
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


US Patent US9351965 (2016)


BindingDB Entry DOI: 10.7270/Q2GT5M11
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233412
PNG
(US9351965, 19)
Show SMILES Cn1cc2cc(ccc2n1)-c1n[nH]c2ccc(cc12)C(=O)N[C@@H]1CCC[C@](O)(Cc2c(F)cccc2F)C1 |r|
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


US Patent US9351965 (2016)


BindingDB Entry DOI: 10.7270/Q2GT5M11
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233436
PNG
(US9351965, 43 | US9351965, 44 | US9351965, 45)
Show SMILES Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)NC1CCCC(CO)(C1)Oc1cccc(F)c1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


US Patent US9351965 (2016)


BindingDB Entry DOI: 10.7270/Q2GT5M11
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233515
PNG
(US9351965, 122)
Show SMILES Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)NC1CCCC(Cn2cc3ccccc3n2)C1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


US Patent US9351965 (2016)


BindingDB Entry DOI: 10.7270/Q2GT5M11
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233405
PNG
(US9351965, 12)
Show SMILES Cc1nc2ccc(cn2n1)-c1n[nH]c2ccc(cc12)C(=O)N[C@@H]1CCC[C@](O)(Cc2ccccc2F)C1 |r|
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


US Patent US9351965 (2016)


BindingDB Entry DOI: 10.7270/Q2GT5M11
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233398
PNG
(US9351965, 5 | US9351965, 6 | US9351965, 7 | US935...)
Show SMILES Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)NC1CCCC(O)(Cc2c(F)cccc2F)C1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


US Patent US9351965 (2016)


BindingDB Entry DOI: 10.7270/Q2GT5M11
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233407
PNG
(US9351965, 14)
Show SMILES Cc1nc2ccc(cc2s1)-c1n[nH]c2ccc(cc12)C(=O)N[C@@H]1CCC[C@](O)(Cc2c(F)cccc2F)C1 |r|
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


US Patent US9351965 (2016)


BindingDB Entry DOI: 10.7270/Q2GT5M11
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233507
PNG
(US9351965, 114)
Show SMILES Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)NC1CCCC(Cn2ncc3cccnc23)C1
PDB
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


US Patent US9351965 (2016)


BindingDB Entry DOI: 10.7270/Q2GT5M11
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233513
PNG
(US9351965, 120)
Show SMILES Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)NC1CCCC(CN2C(=O)Cc3ccccc23)C1
PDB
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


US Patent US9351965 (2016)


BindingDB Entry DOI: 10.7270/Q2GT5M11
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233531
PNG
(US9351965, 138 | US9351965, 139)
Show SMILES Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)NC1CCC(CO)(Cc2ccccc2F)C1
PDB
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


US Patent US9351965 (2016)


BindingDB Entry DOI: 10.7270/Q2GT5M11
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233454
PNG
(US9351965, 61)
Show SMILES Cn1cc2cc(ccc2n1)-c1n[nH]c2ccc(cc12)C(=O)N[C@@H]1CCC[C@](O)(Cn2cnc3ccccc23)C1 |r|
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


US Patent US9351965 (2016)


BindingDB Entry DOI: 10.7270/Q2GT5M11
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233455
PNG
(US9351965, 62)
Show SMILES Cn1cc2cc(ccc2n1)-c1n[nH]c2ccc(cc12)C(=O)N[C@@H]1CCC[C@@](O)(Cn2cnc3ccccc23)C1 |r|
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


US Patent US9351965 (2016)


BindingDB Entry DOI: 10.7270/Q2GT5M11
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233406
PNG
(US9351965, 13)
Show SMILES Cc1nc2ccc(cc2s1)-c1n[nH]c2ccc(cc12)C(=O)N[C@@H]1CCC[C@](O)(Cc2ccccc2F)C1 |r|
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


US Patent US9351965 (2016)


BindingDB Entry DOI: 10.7270/Q2GT5M11
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233394
PNG
(US9351965, 1 | US9351965, 2 | US9351965, 3 | US935...)
Show SMILES Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)NC1CCCC(O)(Cc2ccccc2F)C1
PDB
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


US Patent US9351965 (2016)


BindingDB Entry DOI: 10.7270/Q2GT5M11
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233414
PNG
(US9351965, 21)
Show SMILES Cc1nc2ccc(cn2n1)-c1n[nH]c2ccc(cc12)C(=O)N[C@@H]1CCC[C@](O)(Cc2c(F)cccc2F)C1 |r|
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


US Patent US9351965 (2016)


BindingDB Entry DOI: 10.7270/Q2GT5M11
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233502
PNG
(US9351965, 109)
Show SMILES Cn1cc2cc(ccc2n1)-c1n[nH]c2ccc(cc12)C(=O)NC1CCCC(Cn2cnc3ccccc23)C1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


US Patent US9351965 (2016)


BindingDB Entry DOI: 10.7270/Q2GT5M11
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233496
PNG
(US9351965, 103)
Show SMILES Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)N[C@H]1CCC[C@](O)(Cn2ncc3c(F)cccc23)C1 |r|
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


US Patent US9351965 (2016)


BindingDB Entry DOI: 10.7270/Q2GT5M11
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233442
PNG
(US9351965, 49 | US9351965, 50 | US9351965, 51 | US...)
Show SMILES Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)NC1CCCC(O)(C1)C(O)c1ccccc1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


US Patent US9351965 (2016)


BindingDB Entry DOI: 10.7270/Q2GT5M11
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233535
PNG
(US9351965, 142 | US9351965, 143)
Show SMILES Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)NN1CCCC(C1)Oc1ccccc1F
PDB
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


US Patent US9351965 (2016)


BindingDB Entry DOI: 10.7270/Q2GT5M11
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233483
PNG
(US9351965, 90)
Show SMILES Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)N[C@@H]1CCC[C@](O)(Cn2cc3ccccc3n2)C1 |r|
PDB
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n/an/a 27.4n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


US Patent US9351965 (2016)


BindingDB Entry DOI: 10.7270/Q2GT5M11
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233432
PNG
(US9351965, 39 | US9351965, 40)
Show SMILES COC1(Cc2ccccc2F)CCCC(C1)NC(=O)c1ccc2[nH]nc(-c3ccnc(C)c3)c2c1
PDB
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


US Patent US9351965 (2016)


BindingDB Entry DOI: 10.7270/Q2GT5M11
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233538
PNG
(US9351965, 145)
Show SMILES Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)NN1CCCC1CCc1ccccc1
PDB
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


US Patent US9351965 (2016)


BindingDB Entry DOI: 10.7270/Q2GT5M11
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233501
PNG
(US9351965, 108)
Show SMILES Cn1cc2cc(ccc2n1)-c1n[nH]c2ccc(cc12)C(=O)NC1CCCC(Cn2ccnc2)C1
PDB
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


US Patent US9351965 (2016)


BindingDB Entry DOI: 10.7270/Q2GT5M11
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233429
PNG
(US9351965, 140 | US9351965, 141 | US9351965, 36)
Show SMILES Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)NN1CCCC(C1)Oc1ccccc1Cl
PDB
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


US Patent US9351965 (2016)


BindingDB Entry DOI: 10.7270/Q2GT5M11
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233543
PNG
(US9351965, 150)
Show SMILES Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)NN1CCC(CO)(Cc2ccccc2F)C1
PDB
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


US Patent US9351965 (2016)


BindingDB Entry DOI: 10.7270/Q2GT5M11
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233508
PNG
(US9351965, 115)
Show SMILES Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)NC1CCCC(Cn2ncc3ccncc23)C1
PDB
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


US Patent US9351965 (2016)


BindingDB Entry DOI: 10.7270/Q2GT5M11
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233413
PNG
(US9351965, 20)
Show SMILES O[C@]1(Cc2c(F)cccc2F)CCC[C@H](C1)NC(=O)c1ccc2[nH]nc(-c3ccc4ncsc4c3)c2c1 |r|
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


US Patent US9351965 (2016)


BindingDB Entry DOI: 10.7270/Q2GT5M11
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233487
PNG
(US9351965, 94)
Show SMILES Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)N[C@@H]1CCC[C@@](O)(Cn2cc3ccccc3n2)C1 |r|
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


US Patent US9351965 (2016)


BindingDB Entry DOI: 10.7270/Q2GT5M11
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233473
PNG
(US9351965, 80)
Show SMILES Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)N[C@@H]1CCC[C@@](O)(Cn2ncc3ccncc23)C1 |r|
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


US Patent US9351965 (2016)


BindingDB Entry DOI: 10.7270/Q2GT5M11
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233514
PNG
(US9351965, 121)
Show SMILES Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)NC1CCCC(Cn2c3ccccc3ccc2=O)C1
PDB
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


US Patent US9351965 (2016)


BindingDB Entry DOI: 10.7270/Q2GT5M11
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233450
PNG
(US9351965, 57)
Show SMILES Cn1cc2cc(ccc2n1)-c1n[nH]c2ccc(cc12)C(=O)N[C@@H]1CCC[C@@](O)(Cn2ccnc2)C1 |r|
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


US Patent US9351965 (2016)


BindingDB Entry DOI: 10.7270/Q2GT5M11
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233422
PNG
(BDBM233428 | US9351965, 29 | US9351965, 30 | US935...)
Show SMILES Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)NC1CCCC(C1)Oc1ccccc1Cl
PDB
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


US Patent US9351965 (2016)


BindingDB Entry DOI: 10.7270/Q2GT5M11
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233429
PNG
(US9351965, 140 | US9351965, 141 | US9351965, 36)
Show SMILES Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)NN1CCCC(C1)Oc1ccccc1Cl
PDB
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


US Patent US9351965 (2016)


BindingDB Entry DOI: 10.7270/Q2GT5M11
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233410
PNG
(US9351965, 17)
Show SMILES CC(C)Oc1ccc(cn1)-c1n[nH]c2ccc(cc12)C(=O)N[C@@H]1CCC[C@](O)(Cc2ccccc2F)C1 |r|
PDB
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


US Patent US9351965 (2016)


BindingDB Entry DOI: 10.7270/Q2GT5M11
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233442
PNG
(US9351965, 49 | US9351965, 50 | US9351965, 51 | US...)
Show SMILES Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)NC1CCCC(O)(C1)C(O)c1ccccc1
PDB
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


US Patent US9351965 (2016)


BindingDB Entry DOI: 10.7270/Q2GT5M11
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233402
PNG
(US9351965, 9)
Show SMILES OC1(Cc2ccccc2F)CCCC(C1)NC(=O)c1ccc2[nH]nc(-c3ccc4nccn4c3)c2c1
PDB
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


US Patent US9351965 (2016)


BindingDB Entry DOI: 10.7270/Q2GT5M11
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233462
PNG
(US9351965, 69)
Show SMILES Cc1nc2ccccc2n1C[C@]1(O)CCC[C@@H](C1)NC(=O)c1ccc2[nH]nc(-c3ccnc(C)c3)c2c1 |r|
PDB
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


US Patent US9351965 (2016)


BindingDB Entry DOI: 10.7270/Q2GT5M11
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233519
PNG
(US9351965, 126)
Show SMILES Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)NC1CCCC(Cn2ncc3cccc(F)c23)C1
PDB
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n/an/a 56.6n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


US Patent US9351965 (2016)


BindingDB Entry DOI: 10.7270/Q2GT5M11
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233511
PNG
(US9351965, 118)
Show SMILES Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)NC1CCCC(Cn2cnc3cccnc23)C1
PDB
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


US Patent US9351965 (2016)


BindingDB Entry DOI: 10.7270/Q2GT5M11
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233420
PNG
(US9351965, 27 | US9351965, 28 | US9351965, 33)
Show SMILES Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)NC1CCCC(C1)Oc1ccccc1F
PDB
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


US Patent US9351965 (2016)


BindingDB Entry DOI: 10.7270/Q2GT5M11
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233451
PNG
(US9351965, 58)
Show SMILES Cn1cc2cc(ccc2n1)-c1n[nH]c2ccc(cc12)C(=O)N[C@@H]1CCC[C@](O)(Cn2ccnc2)C1 |r|
PDB
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


US Patent US9351965 (2016)


BindingDB Entry DOI: 10.7270/Q2GT5M11
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233531
PNG
(US9351965, 138 | US9351965, 139)
Show SMILES Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)NC1CCC(CO)(Cc2ccccc2F)C1
PDB
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


US Patent US9351965 (2016)


BindingDB Entry DOI: 10.7270/Q2GT5M11
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233452
PNG
(US9351965, 59)
Show SMILES Cn1cc2cc(ccc2n1)-c1n[nH]c2ccc(cc12)C(=O)N[C@@H]1CCC[C@](O)(Cn2cccn2)C1 |r|
PDB
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


US Patent US9351965 (2016)


BindingDB Entry DOI: 10.7270/Q2GT5M11
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233497
PNG
(US9351965, 104)
Show SMILES Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)N[C@H]1CCC[C@@](O)(Cn2ncc3cccc(F)c23)C1 |r|
PDB
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n/an/a 74.3n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


US Patent US9351965 (2016)


BindingDB Entry DOI: 10.7270/Q2GT5M11
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233503
PNG
(US9351965, 110)
Show SMILES O=C(NC1CCCC(Cn2cccn2)C1)c1ccc2[nH]nc(-c3ccc4nccn4c3)c2c1
PDB
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


US Patent US9351965 (2016)


BindingDB Entry DOI: 10.7270/Q2GT5M11
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233504
PNG
(US9351965, 111)
Show SMILES O=C(NC1CCCC(Cn2cncn2)C1)c1ccc2[nH]nc(-c3ccc4nccn4c3)c2c1
PDB
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


US Patent US9351965 (2016)


BindingDB Entry DOI: 10.7270/Q2GT5M11
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233419
PNG
(US9351965, 26)
Show SMILES COc1cccc(F)c1C[C@@]1(O)CCC[C@H](C1)NC(=O)c1ccc2[nH]nc(-c3ccc(OC(C)C)cc3)c2c1 |r|
PDB
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


US Patent US9351965 (2016)


BindingDB Entry DOI: 10.7270/Q2GT5M11
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233429
PNG
(US9351965, 140 | US9351965, 141 | US9351965, 36)
Show SMILES Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)NN1CCCC(C1)Oc1ccccc1Cl
PDB
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


US Patent US9351965 (2016)


BindingDB Entry DOI: 10.7270/Q2GT5M11
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233510
PNG
(US9351965, 117)
Show SMILES Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)NC1CCCC(Cn2cnc3ncccc23)C1
PDB
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n/an/a 86.5n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


US Patent US9351965 (2016)


BindingDB Entry DOI: 10.7270/Q2GT5M11
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233475
PNG
(US9351965, 82)
Show SMILES Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)N[C@@H]1CCC[C@@](O)(Cn2cnc3cccnc23)C1 |r|
PDB
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


US Patent US9351965 (2016)


BindingDB Entry DOI: 10.7270/Q2GT5M11
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233434
PNG
(US9351965, 41)
Show SMILES Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)NC1CCCC(CO)(C1)Oc1ccccc1
PDB
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


US Patent US9351965 (2016)


BindingDB Entry DOI: 10.7270/Q2GT5M11
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233457
PNG
(US9351965, 64)
Show SMILES Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)N[C@@H]1CCC[C@@](O)(Cn2cncn2)C1 |r|
PDB
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


US Patent US9351965 (2016)


BindingDB Entry DOI: 10.7270/Q2GT5M11
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233439
PNG
(US9351965, 46 | US9351965, 48)
Show SMILES Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)NC1CCCC(O)(C1)C(F)(F)c1ccccc1
PDB
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


US Patent US9351965 (2016)


BindingDB Entry DOI: 10.7270/Q2GT5M11
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233499
PNG
(US9351965, 106)
Show SMILES Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)N[C@H]1CCC[C@](O)(Cn2ncc3ccc(cc23)C(F)(F)F)C1 |r|
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


US Patent US9351965 (2016)


BindingDB Entry DOI: 10.7270/Q2GT5M11
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233523
PNG
(US9351965, 130 | US9351965, 133)
Show SMILES Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)NC1CCCC(CO)(Cc2ccccc2F)C1
PDB
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


US Patent US9351965 (2016)


BindingDB Entry DOI: 10.7270/Q2GT5M11
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233420
PNG
(US9351965, 27 | US9351965, 28 | US9351965, 33)
Show SMILES Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)NC1CCCC(C1)Oc1ccccc1F
PDB
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


US Patent US9351965 (2016)


BindingDB Entry DOI: 10.7270/Q2GT5M11
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233420
PNG
(US9351965, 27 | US9351965, 28 | US9351965, 33)
Show SMILES Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)NC1CCCC(C1)Oc1ccccc1F
PDB
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


US Patent US9351965 (2016)


BindingDB Entry DOI: 10.7270/Q2GT5M11
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233394
PNG
(US9351965, 1 | US9351965, 2 | US9351965, 3 | US935...)
Show SMILES Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)NC1CCCC(O)(Cc2ccccc2F)C1
PDB
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


US Patent US9351965 (2016)


BindingDB Entry DOI: 10.7270/Q2GT5M11
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233430
PNG
(US9351965, 37 | US9351965, 38)
Show SMILES Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)NC1CCCC(C1)Oc1ccc(F)cc1F
PDB
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


US Patent US9351965 (2016)


BindingDB Entry DOI: 10.7270/Q2GT5M11
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233469
PNG
(US9351965, 76)
Show SMILES Cc1nc2cnccc2n1C[C@@]1(O)CCC[C@H](C1)NC(=O)c1ccc2[nH]nc(-c3ccnc(C)c3)c2c1 |r|
PDB
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


US Patent US9351965 (2016)


BindingDB Entry DOI: 10.7270/Q2GT5M11
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233411
PNG
(US9351965, 18)
Show SMILES CC(C)Oc1ccc(cn1)-c1n[nH]c2ccc(cc12)C(=O)N[C@@H]1CCC[C@](O)(Cc2c(F)cccc2F)C1 |r|
PDB
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


US Patent US9351965 (2016)


BindingDB Entry DOI: 10.7270/Q2GT5M11
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233453
PNG
(US9351965, 60)
Show SMILES Cn1cc2cc(ccc2n1)-c1n[nH]c2ccc(cc12)C(=O)N[C@@H]1CCC[C@@](O)(Cn2cccn2)C1 |r|
PDB
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


US Patent US9351965 (2016)


BindingDB Entry DOI: 10.7270/Q2GT5M11
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233535
PNG
(US9351965, 142 | US9351965, 143)
Show SMILES Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)NN1CCCC(C1)Oc1ccccc1F
PDB
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


US Patent US9351965 (2016)


BindingDB Entry DOI: 10.7270/Q2GT5M11
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233546
PNG
(US9351965, 153)
Show SMILES Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)NC1CCCC(Cc2ccccc2F)(C1)NC=O
PDB
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


US Patent US9351965 (2016)


BindingDB Entry DOI: 10.7270/Q2GT5M11
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233506
PNG
(US9351965, 113)
Show SMILES Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)NC1CCCC(Cn2cc3cccnc3n2)C1
PDB
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


US Patent US9351965 (2016)


BindingDB Entry DOI: 10.7270/Q2GT5M11
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233486
PNG
(US9351965, 93)
Show SMILES Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)N[C@@H]1CCC[C@@](O)(Cn2c3ccccc3ccc2=O)C1 |r|
PDB
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


US Patent US9351965 (2016)


BindingDB Entry DOI: 10.7270/Q2GT5M11
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233436
PNG
(US9351965, 43 | US9351965, 44 | US9351965, 45)
Show SMILES Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)NC1CCCC(CO)(C1)Oc1cccc(F)c1
PDB
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


US Patent US9351965 (2016)


BindingDB Entry DOI: 10.7270/Q2GT5M11
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233422
PNG
(BDBM233428 | US9351965, 29 | US9351965, 30 | US935...)
Show SMILES Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)NC1CCCC(C1)Oc1ccccc1Cl
PDB
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


US Patent US9351965 (2016)


BindingDB Entry DOI: 10.7270/Q2GT5M11
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233544
PNG
(US9351965, 151)
Show SMILES Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)NN1CCCC(CO)(Cc2ccccc2F)C1
PDB
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


US Patent US9351965 (2016)


BindingDB Entry DOI: 10.7270/Q2GT5M11
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233456
PNG
(US9351965, 63)
Show SMILES Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)N[C@@H]1CCC[C@](O)(Cn2cncn2)C1 |r|
PDB
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


US Patent US9351965 (2016)


BindingDB Entry DOI: 10.7270/Q2GT5M11
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233422
PNG
(BDBM233428 | US9351965, 29 | US9351965, 30 | US935...)
Show SMILES Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)NC1CCCC(C1)Oc1ccccc1Cl
PDB
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


US Patent US9351965 (2016)


BindingDB Entry DOI: 10.7270/Q2GT5M11
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233442
PNG
(US9351965, 49 | US9351965, 50 | US9351965, 51 | US...)
Show SMILES Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)NC1CCCC(O)(C1)C(O)c1ccccc1
PDB
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


US Patent US9351965 (2016)


BindingDB Entry DOI: 10.7270/Q2GT5M11
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233432
PNG
(US9351965, 39 | US9351965, 40)
Show SMILES COC1(Cc2ccccc2F)CCCC(C1)NC(=O)c1ccc2[nH]nc(-c3ccnc(C)c3)c2c1
PDB
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


US Patent US9351965 (2016)


BindingDB Entry DOI: 10.7270/Q2GT5M11
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233436
PNG
(US9351965, 43 | US9351965, 44 | US9351965, 45)
Show SMILES Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)NC1CCCC(CO)(C1)Oc1cccc(F)c1
PDB
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


US Patent US9351965 (2016)


BindingDB Entry DOI: 10.7270/Q2GT5M11
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233525
PNG
(US9351965, 132)
Show SMILES Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)NC1CCCC(CO)(Cc2ccccc2)C1
PDB
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


US Patent US9351965 (2016)


BindingDB Entry DOI: 10.7270/Q2GT5M11
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233440
PNG
(US9351965, 47 | US9351965, 53)
Show SMILES Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)NC1CCCC(O)(C1)C(=O)c1ccccc1
PDB
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


US Patent US9351965 (2016)


BindingDB Entry DOI: 10.7270/Q2GT5M11
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233517
PNG
(US9351965, 124)
Show SMILES Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)NC1CCCC(Cn2cc3cc(F)ccc3n2)C1
PDB
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n/an/a 264n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


US Patent US9351965 (2016)


BindingDB Entry DOI: 10.7270/Q2GT5M11
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233403
PNG
(US9351965, 10 | US9351965, 11)
Show SMILES OC1(Cc2ccccc2F)CCCC(C1)NC(=O)c1ccc2[nH]nc(-c3ccc4ncsc4c3)c2c1
PDB
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


US Patent US9351965 (2016)


BindingDB Entry DOI: 10.7270/Q2GT5M11
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233442
PNG
(US9351965, 49 | US9351965, 50 | US9351965, 51 | US...)
Show SMILES Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)NC1CCCC(O)(C1)C(O)c1ccccc1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


US Patent US9351965 (2016)


BindingDB Entry DOI: 10.7270/Q2GT5M11
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233409
PNG
(US9351965, 16)
Show SMILES CC(C)Oc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)N[C@@H]1CCC[C@](O)(Cc2ccccc2F)C1 |r|
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


US Patent US9351965 (2016)


BindingDB Entry DOI: 10.7270/Q2GT5M11
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233529
PNG
(US9351965, 136)
Show SMILES Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)NC1CCCC(Cc2ccc(F)cc2)(C1)C(O)=O
PDB
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


US Patent US9351965 (2016)


BindingDB Entry DOI: 10.7270/Q2GT5M11
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233463
PNG
(US9351965, 70)
Show SMILES Cc1nc2ccccc2n1C[C@@]1(O)CCC[C@@H](C1)NC(=O)c1ccc2[nH]nc(-c3ccnc(C)c3)c2c1 |r|
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


US Patent US9351965 (2016)


BindingDB Entry DOI: 10.7270/Q2GT5M11
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233418
PNG
(US9351965, 25)
Show SMILES COc1cccc(F)c1C[C@@]1(O)CCC[C@H](C1)NC(=O)c1ccc2[nH]nc(-c3ccnc(OC(C)C)c3)c2c1 |r|
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


US Patent US9351965 (2016)


BindingDB Entry DOI: 10.7270/Q2GT5M11
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233528
PNG
(US9351965, 135)
Show SMILES Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)NC1CCCC(CO)(Cc2ccc(F)cc2)C1
PDB
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


US Patent US9351965 (2016)


BindingDB Entry DOI: 10.7270/Q2GT5M11
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233500
PNG
(US9351965, 107)
Show SMILES Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)N[C@H]1CCC[C@](O)(Cn2ncc3ccc(F)cc23)C1 |r|
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


US Patent US9351965 (2016)


BindingDB Entry DOI: 10.7270/Q2GT5M11
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233540
PNG
(US9351965, 147)
Show SMILES Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)NN1CCCC(CO)(C1)Oc1cc(F)ccc1F
PDB
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


US Patent US9351965 (2016)


BindingDB Entry DOI: 10.7270/Q2GT5M11
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233466
PNG
(US9351965, 73 | US9351965, 75)
Show SMILES Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)N[C@@H]1CCC[C@](O)(Cn2cc3cccnc3n2)C1 |r|
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


US Patent US9351965 (2016)


BindingDB Entry DOI: 10.7270/Q2GT5M11
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233480
PNG
(US9351965, 87)
Show SMILES Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)N[C@@H]1CCC[C@](O)(Cn2ncc3cnccc23)C1 |r|
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


US Patent US9351965 (2016)


BindingDB Entry DOI: 10.7270/Q2GT5M11
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233460
PNG
(US9351965, 67)
Show SMILES Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)N[C@@H]1CCC[C@](O)(Cn2c(nc3ccccc23)C(F)(F)F)C1 |r|
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


US Patent US9351965 (2016)


BindingDB Entry DOI: 10.7270/Q2GT5M11
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233527
PNG
(US9351965, 134)
Show SMILES Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)NC1CCCC(CO)(Cc2ccc(F)cc2F)C1
PDB
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


US Patent US9351965 (2016)


BindingDB Entry DOI: 10.7270/Q2GT5M11
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233522
PNG
(US9351965, 129 | US9351965, 137)
Show SMILES Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)NC1CCCC(CO)(Cc2c(F)cccc2F)C1
PDB
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


US Patent US9351965 (2016)


BindingDB Entry DOI: 10.7270/Q2GT5M11
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233541
PNG
(US9351965, 148)
Show SMILES Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)NN1CCCC(CO)(C1)Oc1ccc(F)cc1
PDB
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


US Patent US9351965 (2016)


BindingDB Entry DOI: 10.7270/Q2GT5M11
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233464
PNG
(US9351965, 71)
Show SMILES Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)N[C@@H]1CCC[C@](O)(Cn2cnc3ncccc23)C1 |r|
PDB
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


US Patent US9351965 (2016)


BindingDB Entry DOI: 10.7270/Q2GT5M11
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233424
PNG
(US9351965, 31)
Show SMILES Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)NC1CCCC(C1)Oc1c(C)cccc1C
PDB
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


US Patent US9351965 (2016)


BindingDB Entry DOI: 10.7270/Q2GT5M11
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233430
PNG
(US9351965, 37 | US9351965, 38)
Show SMILES Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)NC1CCCC(C1)Oc1ccc(F)cc1F
PDB
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


US Patent US9351965 (2016)


BindingDB Entry DOI: 10.7270/Q2GT5M11
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233537
PNG
(US9351965, 144)
Show SMILES CC(C)Oc1ccc(cn1)-c1n[nH]c2ccc(cc12)C(=O)NN1CCCC1CCc1ccccc1
PDB
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


US Patent US9351965 (2016)


BindingDB Entry DOI: 10.7270/Q2GT5M11
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233481
PNG
(US9351965, 88)
Show SMILES Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)N[C@@H]1CCC[C@](O)(CN2C(=O)Cc3ccccc23)C1 |r|
PDB
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


US Patent US9351965 (2016)


BindingDB Entry DOI: 10.7270/Q2GT5M11
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233545
PNG
(US9351965, 152)
Show SMILES Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)NC1CCCC(N)(Cc2ccccc2F)C1
PDB
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


US Patent US9351965 (2016)


BindingDB Entry DOI: 10.7270/Q2GT5M11
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233512
PNG
(US9351965, 119)
Show SMILES Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)NC1CCCC(Cn2ncc3cnccc23)C1
PDB
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


US Patent US9351965 (2016)


BindingDB Entry DOI: 10.7270/Q2GT5M11
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233465
PNG
(US9351965, 72)
Show SMILES Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)N[C@@H]1CCC[C@](O)(Cn2cnc3cccnc23)C1 |r|
PDB
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


US Patent US9351965 (2016)


BindingDB Entry DOI: 10.7270/Q2GT5M11
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233484
PNG
(US9351965, 91)
Show SMILES Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)N[C@@H]1CCC[C@@](O)(Cn2ncc3cnccc23)C1 |r|
PDB
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


US Patent US9351965 (2016)


BindingDB Entry DOI: 10.7270/Q2GT5M11
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233425
PNG
(US9351965, 32)
Show SMILES Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)NC1CCCC(C1)Oc1c(F)cccc1F
PDB
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


US Patent US9351965 (2016)


BindingDB Entry DOI: 10.7270/Q2GT5M11
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233489
PNG
(US9351965, 96)
Show SMILES Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)N[C@H]1CCC[C@@](O)(Cn2ncc3c(F)cccc23)C1 |r|
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


US Patent US9351965 (2016)


BindingDB Entry DOI: 10.7270/Q2GT5M11
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233440
PNG
(US9351965, 47 | US9351965, 53)
Show SMILES Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)NC1CCCC(O)(C1)C(=O)c1ccccc1
PDB
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


US Patent US9351965 (2016)


BindingDB Entry DOI: 10.7270/Q2GT5M11
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233394
PNG
(US9351965, 1 | US9351965, 2 | US9351965, 3 | US935...)
Show SMILES Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)NC1CCCC(O)(Cc2ccccc2F)C1
PDB
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


US Patent US9351965 (2016)


BindingDB Entry DOI: 10.7270/Q2GT5M11
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233471
PNG
(US9351965, 78)
Show SMILES Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)N[C@@H]1CCC[C@@](O)(Cn2cc3cccnc3n2)C1 |r|
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n/an/a 591n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


US Patent US9351965 (2016)


BindingDB Entry DOI: 10.7270/Q2GT5M11
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233466
PNG
(US9351965, 73 | US9351965, 75)
Show SMILES Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)N[C@@H]1CCC[C@](O)(Cn2cc3cccnc3n2)C1 |r|
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n/an/a 616n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


US Patent US9351965 (2016)


BindingDB Entry DOI: 10.7270/Q2GT5M11
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233439
PNG
(US9351965, 46 | US9351965, 48)
Show SMILES Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)NC1CCCC(O)(C1)C(F)(F)c1ccccc1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


US Patent US9351965 (2016)


BindingDB Entry DOI: 10.7270/Q2GT5M11
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233522
PNG
(US9351965, 129 | US9351965, 137)
Show SMILES Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)NC1CCCC(CO)(Cc2c(F)cccc2F)C1
PDB
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


US Patent US9351965 (2016)


BindingDB Entry DOI: 10.7270/Q2GT5M11
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233495
PNG
(US9351965, 102)
Show SMILES Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)N[C@H]1CCC[C@@](O)(Cn2cc3cccc(F)c3n2)C1 |r|
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


US Patent US9351965 (2016)


BindingDB Entry DOI: 10.7270/Q2GT5M11
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233482
PNG
(US9351965, 89)
Show SMILES Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)N[C@@H]1CCC[C@](O)(Cn2c3ccccc3ccc2=O)C1 |r|
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


US Patent US9351965 (2016)


BindingDB Entry DOI: 10.7270/Q2GT5M11
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233492
PNG
(US9351965, 101 | US9351965, 99)
Show SMILES Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)N[C@H]1CCC[C@@](O)(Cn2cc3cc(F)ccc3n2)C1 |r|
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


US Patent US9351965 (2016)


BindingDB Entry DOI: 10.7270/Q2GT5M11
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233467
PNG
(US9351965, 74)
Show SMILES Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)N[C@@H]1CCC[C@](O)(Cn2ncc3ccncc23)C1 |r|
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


US Patent US9351965 (2016)


BindingDB Entry DOI: 10.7270/Q2GT5M11
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233461
PNG
(US9351965, 68)
Show SMILES Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)N[C@@H]1CCC[C@@](O)(Cn2c(nc3ccccc23)C(F)(F)F)C1 |r|
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


US Patent US9351965 (2016)


BindingDB Entry DOI: 10.7270/Q2GT5M11
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233474
PNG
(US9351965, 81)
Show SMILES Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)N[C@@H]1CCC[C@@](O)(Cn2cnc3ncccc23)C1 |r|
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


US Patent US9351965 (2016)


BindingDB Entry DOI: 10.7270/Q2GT5M11
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233542
PNG
(US9351965, 149)
Show SMILES COCC1(Cc2ccccc2F)CCCN(C1)NC(=O)c1ccc2[nH]nc(-c3ccnc(C)c3)c2c1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


US Patent US9351965 (2016)


BindingDB Entry DOI: 10.7270/Q2GT5M11
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233458
PNG
(US9351965, 65)
Show SMILES Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)N[C@@H]1CCC[C@](O)(Cn2ncc3ccccc23)C1 |r|
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


US Patent US9351965 (2016)


BindingDB Entry DOI: 10.7270/Q2GT5M11
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233470
PNG
(US9351965, 77)
Show SMILES Cc1nc2cnccc2n1C[C@]1(O)CCC[C@H](C1)NC(=O)c1ccc2[nH]nc(-c3ccnc(C)c3)c2c1 |r|
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


US Patent US9351965 (2016)


BindingDB Entry DOI: 10.7270/Q2GT5M11
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233479
PNG
(US9351965, 86)
Show SMILES O[C@@]1(Cn2ncc3ncccc23)CCC[C@H](C1)NC(=O)c1ccc2[nH]nc(-c3ccc4nccn4c3)c2c1 |r|
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


US Patent US9351965 (2016)


BindingDB Entry DOI: 10.7270/Q2GT5M11
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233488
PNG
(US9351965, 95)
Show SMILES Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)N[C@H]1CCC[C@@](O)(Cn2cc(C#N)c3ccccc23)C1 |r|
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


US Patent US9351965 (2016)


BindingDB Entry DOI: 10.7270/Q2GT5M11
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233403
PNG
(US9351965, 10 | US9351965, 11)
Show SMILES OC1(Cc2ccccc2F)CCCC(C1)NC(=O)c1ccc2[nH]nc(-c3ccc4ncsc4c3)c2c1
PDB
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


US Patent US9351965 (2016)


BindingDB Entry DOI: 10.7270/Q2GT5M11
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233422
PNG
(BDBM233428 | US9351965, 29 | US9351965, 30 | US935...)
Show SMILES Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)NC1CCCC(C1)Oc1ccccc1Cl
PDB
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


US Patent US9351965 (2016)


BindingDB Entry DOI: 10.7270/Q2GT5M11
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233520
PNG
(US9351965, 127)
Show SMILES Cc1nc2ccc(cc2s1)-c1n[nH]c2ccc(cc12)C(=O)NC1CCCC(Cn2c(C)nc3ccccc23)C1
PDB
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


US Patent US9351965 (2016)


BindingDB Entry DOI: 10.7270/Q2GT5M11
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233524
PNG
(US9351965, 131)
Show SMILES Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)NC1CCCC(Cc2ccccc2F)(C1)C(O)=O
PDB
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


US Patent US9351965 (2016)


BindingDB Entry DOI: 10.7270/Q2GT5M11
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233398
PNG
(US9351965, 5 | US9351965, 6 | US9351965, 7 | US935...)
Show SMILES Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)NC1CCCC(O)(Cc2c(F)cccc2F)C1
PDB
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


US Patent US9351965 (2016)


BindingDB Entry DOI: 10.7270/Q2GT5M11
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233490
PNG
(US9351965, 97)
Show SMILES Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)N[C@H]1CCC[C@@](O)(Cn2cc3c(F)cccc3n2)C1 |r|
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


US Patent US9351965 (2016)


BindingDB Entry DOI: 10.7270/Q2GT5M11
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233539
PNG
(US9351965, 146)
Show SMILES CC(C)Oc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)NN1CCCC1CCc1ccccc1
PDB
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


US Patent US9351965 (2016)


BindingDB Entry DOI: 10.7270/Q2GT5M11
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233398
PNG
(US9351965, 5 | US9351965, 6 | US9351965, 7 | US935...)
Show SMILES Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)NC1CCCC(O)(Cc2c(F)cccc2F)C1
PDB
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


US Patent US9351965 (2016)


BindingDB Entry DOI: 10.7270/Q2GT5M11
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233476
PNG
(US9351965, 83)
Show SMILES Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)N[C@@H]1CCC[C@](O)(Cn2ncccc2=O)C1 |r|
PDB
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


US Patent US9351965 (2016)


BindingDB Entry DOI: 10.7270/Q2GT5M11
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233521
PNG
(US9351965, 128)
Show SMILES CCOC(=O)C1(Cc2ccccc2F)CCCC(C1)NC(=O)c1ccc2[nH]nc(-c3ccnc(C)c3)c2c1
PDB
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


US Patent US9351965 (2016)


BindingDB Entry DOI: 10.7270/Q2GT5M11
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233491
PNG
(US9351965, 98)
Show SMILES Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)N[C@H]1CCC[C@@](O)(Cn2ncc3cc(F)ccc23)C1 |r|
PDB
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


US Patent US9351965 (2016)


BindingDB Entry DOI: 10.7270/Q2GT5M11
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233448
PNG
(US9351965, 55)
Show SMILES Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)N[C@@H]1CCCC(F)(Cc2ccccc2F)C1 |r|
PDB
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


US Patent US9351965 (2016)


BindingDB Entry DOI: 10.7270/Q2GT5M11
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233493
PNG
(US9351965, 100)
Show SMILES Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)N[C@H]1CCC[C@@](O)(Cn2ncc3ccc(F)cc23)C1 |r|
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


US Patent US9351965 (2016)


BindingDB Entry DOI: 10.7270/Q2GT5M11
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233478
PNG
(US9351965, 85)
Show SMILES O[C@]1(Cn2ccccc2=O)CCC[C@H](C1)NC(=O)c1ccc2[nH]nc(-c3ccc4nccn4c3)c2c1 |r|
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


US Patent US9351965 (2016)


BindingDB Entry DOI: 10.7270/Q2GT5M11
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233447
PNG
(US9351965, 54)
Show SMILES Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)NC1CCCC(F)(Cc2ccccc2F)C1
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US Patent
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


US Patent US9351965 (2016)


BindingDB Entry DOI: 10.7270/Q2GT5M11
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233398
PNG
(US9351965, 5 | US9351965, 6 | US9351965, 7 | US935...)
Show SMILES Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)NC1CCCC(O)(Cc2c(F)cccc2F)C1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


US Patent US9351965 (2016)


BindingDB Entry DOI: 10.7270/Q2GT5M11
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233498
PNG
(US9351965, 105)
Show SMILES Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)N[C@H]1CCC[C@@](O)(Cn2cc3ccc(cc3n2)C(F)(F)F)C1 |r|
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


US Patent US9351965 (2016)


BindingDB Entry DOI: 10.7270/Q2GT5M11
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233492
PNG
(US9351965, 101 | US9351965, 99)
Show SMILES Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)N[C@H]1CCC[C@@](O)(Cn2cc3cc(F)ccc3n2)C1 |r|
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


US Patent US9351965 (2016)


BindingDB Entry DOI: 10.7270/Q2GT5M11
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233523
PNG
(US9351965, 130 | US9351965, 133)
Show SMILES Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)NC1CCCC(CO)(Cc2ccccc2F)C1
PDB
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


US Patent US9351965 (2016)


BindingDB Entry DOI: 10.7270/Q2GT5M11
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233518
PNG
(US9351965, 125)
Show SMILES Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)NC1CCCC(Cn2ncc3ccc(cc23)C(F)(F)F)C1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


US Patent US9351965 (2016)


BindingDB Entry DOI: 10.7270/Q2GT5M11
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233477
PNG
(US9351965, 84)
Show SMILES Cc1cc(ccn1)-c1n[nH]c2ccc(cc12)C(=O)N[C@@H]1CCC[C@@](O)(Cn2ncccc2=O)C1 |r|
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


US Patent US9351965 (2016)


BindingDB Entry DOI: 10.7270/Q2GT5M11
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233505
PNG
(US9351965, 112)
Show SMILES Cc1nc2ccc(cc2s1)-c1n[nH]c2ccc(cc12)C(=O)NC1CCCC(Cn2cc(C#N)c3ccccc23)C1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


US Patent US9351965 (2016)


BindingDB Entry DOI: 10.7270/Q2GT5M11
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM233509
PNG
(US9351965, 116)
Show SMILES Cc1nc2cnccc2n1CC1CCCC(C1)NC(=O)c1ccc2[nH]nc(-c3ccnc(C)c3)c2c1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was added to 1...


US Patent US9351965 (2016)


BindingDB Entry DOI: 10.7270/Q2GT5M11
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%