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USPatent US9434711

Compile Data Set for Download or QSAR

Found 709 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Transient receptor potential M8 protein


(Canis lupus familiaris (Dog))		BDBM248583
PNG
(US9434711, 496)
Show SMILES Cc1c(sc2ccccc12)N(Cc1ccc(OC(F)(F)F)cc1)S(=O)(=O)c1ccc(cc1)C(O)=O
Show InChI InChI=1S/C24H18F3NO5S2/c1-15-20-4-2-3-5-21(20)34-22(15)28(14-16-6-10-18(11-7-16)33-24(25,26)27)35(31,32)19-12-8-17(9-13-19)23(29)30/h2-13H,14H2,1H3,(H,29,30)
PDB

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n/an/a 0.183n/an/an/an/an/an/a



Janssen Pharmaceutica, N.V.

US Patent


Assay Description
For patch clamp experiments, HEK293 cells are stably transfected with canine TRPM8 and cultured in DMEM supplemented with 10% fetal bovine serum, 100...

US Patent US9434711 (2016)


BindingDB Entry DOI: 10.7270/Q2H41QB6
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein


(Canis lupus familiaris (Dog))		BDBM50036555
PNG
(CHEMBL3353610 | US9434711, 497)
Show SMILES Cc1c(sc2ccccc12)N(Cc1ccc(c(F)c1)C(F)(F)F)S(=O)(=O)c1ccc(cc1)C(O)=O
Show InChI InChI=1S/C24H17F4NO4S2/c1-14-18-4-2-3-5-21(18)34-22(14)29(13-15-6-11-19(20(25)12-15)24(26,27)28)35(32,33)17-9-7-16(8-10-17)23(30)31/h2-12H,13H2,1H3,(H,30,31)
PDB

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n/an/a 0.400n/an/an/an/an/a37



Janssen Pharmaceutica, N.V.

US Patent


Assay Description
The functional activity of compounds of the formula (I) was determined by measuring changes in intracellular calcium concentration using a Ca2+-sensi...

US Patent US9434711 (2016)


BindingDB Entry DOI: 10.7270/Q2H41QB6
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein


(Canis lupus familiaris (Dog))		BDBM248583
PNG
(US9434711, 496)
Show SMILES Cc1c(sc2ccccc12)N(Cc1ccc(OC(F)(F)F)cc1)S(=O)(=O)c1ccc(cc1)C(O)=O
Show InChI InChI=1S/C24H18F3NO5S2/c1-15-20-4-2-3-5-21(20)34-22(15)28(14-16-6-10-18(11-7-16)33-24(25,26)27)35(31,32)19-12-8-17(9-13-19)23(29)30/h2-13H,14H2,1H3,(H,29,30)
PDB

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n/an/a 0.554n/an/an/an/an/an/a



Janssen Pharmaceutica, N.V.

US Patent


Assay Description
For patch clamp experiments, HEK293 cells are stably transfected with canine TRPM8 and cultured in DMEM supplemented with 10% fetal bovine serum, 100...

US Patent US9434711 (2016)


BindingDB Entry DOI: 10.7270/Q2H41QB6
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein


(Canis lupus familiaris (Dog))		BDBM248576
PNG
(US9434711, 489)
Show SMILES Cc1c(sc2ccccc12)N(Cc1ccc(F)c(Cl)c1)S(=O)(=O)c1ccc(cc1)C(O)=O
Show InChI InChI=1S/C23H17ClFNO4S2/c1-14-18-4-2-3-5-21(18)31-22(14)26(13-15-6-11-20(25)19(24)12-15)32(29,30)17-9-7-16(8-10-17)23(27)28/h2-12H,13H2,1H3,(H,27,28)
PDB

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n/an/a 0.600n/an/an/an/an/a37



Janssen Pharmaceutica, N.V.

US Patent


Assay Description
The functional activity of compounds of the formula (I) was determined by measuring changes in intracellular calcium concentration using a Ca2+-sensi...

US Patent US9434711 (2016)


BindingDB Entry DOI: 10.7270/Q2H41QB6
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein


(Canis lupus familiaris (Dog))		BDBM248370
PNG
(US9434711, 227)
Show SMILES CCS(=O)(=O)N(Cc1ccc(F)c(c1)C(F)(F)F)c1sc2ccccc2c1C(C)(C)O
Show InChI InChI=1S/C21H21F4NO3S2/c1-4-31(28,29)26(12-13-9-10-16(22)15(11-13)21(23,24)25)19-18(20(2,3)27)14-7-5-6-8-17(14)30-19/h5-11,27H,4,12H2,1-3H3
PDB

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n/an/a 0.600n/an/an/an/an/a37



Janssen Pharmaceutica, N.V.

US Patent


Assay Description
The functional activity of compounds of the formula (I) was determined by measuring changes in intracellular calcium concentration using a Ca2+-sensi...

US Patent US9434711 (2016)


BindingDB Entry DOI: 10.7270/Q2H41QB6
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein


(Canis lupus familiaris (Dog))		BDBM248838
PNG
(US9434711, 808)
Show SMILES Cc1c(sc2ccccc12)N(Cc1ccc(OC(F)(F)F)cc1)S(=O)(=O)c1ccc(nc1)-c1noc(=O)[nH]1
Show InChI InChI=1S/C24H17F3N4O5S2/c1-14-18-4-2-3-5-20(18)37-22(14)31(13-15-6-8-16(9-7-15)35-24(25,26)27)38(33,34)17-10-11-19(28-12-17)21-29-23(32)36-30-21/h2-12H,13H2,1H3,(H,29,30,32)
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n/an/a 0.700n/an/an/an/an/a37



Janssen Pharmaceutica, N.V.

US Patent


Assay Description
The functional activity of compounds of the formula (I) was determined by measuring changes in intracellular calcium concentration using a Ca2+-sensi...

US Patent US9434711 (2016)


BindingDB Entry DOI: 10.7270/Q2H41QB6
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein


(Canis lupus familiaris (Dog))		BDBM248599
PNG
(US9434711, 518)
Show SMILES Cc1c(sc2ccccc12)N(Cc1ccc(cc1)C(F)(F)F)S(=O)(=O)c1ccc(cc1)C(O)=O
Show InChI InChI=1S/C24H18F3NO4S2/c1-15-20-4-2-3-5-21(20)33-22(15)28(14-16-6-10-18(11-7-16)24(25,26)27)34(31,32)19-12-8-17(9-13-19)23(29)30/h2-13H,14H2,1H3,(H,29,30)
PDB

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Janssen Pharmaceutica, N.V.

US Patent


Assay Description
The functional activity of compounds of the formula (I) was determined by measuring changes in intracellular calcium concentration using a Ca2+-sensi...

US Patent US9434711 (2016)


BindingDB Entry DOI: 10.7270/Q2H41QB6
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein


(Canis lupus familiaris (Dog))		BDBM248426
PNG
(US9434711, 292)
Show SMILES OC(=O)c1ccc(cc1)S(=O)(=O)N(Cc1ccc(F)c(c1)C(F)(F)F)c1sc2ccccc2c1Br
Show InChI InChI=1S/C23H14BrF4NO4S2/c24-20-16-3-1-2-4-19(16)34-21(20)29(12-13-5-10-18(25)17(11-13)23(26,27)28)35(32,33)15-8-6-14(7-9-15)22(30)31/h1-11H,12H2,(H,30,31)
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Janssen Pharmaceutica, N.V.

US Patent


Assay Description
The functional activity of compounds of the formula (I) was determined by measuring changes in intracellular calcium concentration using a Ca2+-sensi...

US Patent US9434711 (2016)


BindingDB Entry DOI: 10.7270/Q2H41QB6
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein


(Canis lupus familiaris (Dog))		BDBM50426573
PNG
(CHEMBL2324349 | US9434711, 306)
Show SMILES Cc1c(sc2ccccc12)N(Cc1ccc(F)c(c1)C(F)(F)F)S(=O)(=O)c1ccc(cc1)C(O)=O
Show InChI InChI=1S/C24H17F4NO4S2/c1-14-18-4-2-3-5-21(18)34-22(14)29(13-15-6-11-20(25)19(12-15)24(26,27)28)35(32,33)17-9-7-16(8-10-17)23(30)31/h2-12H,13H2,1H3,(H,30,31)
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n/an/a 0.800n/an/an/an/an/a37



Janssen Pharmaceutica, N.V.

US Patent


Assay Description
The functional activity of compounds of the formula (I) was determined by measuring changes in intracellular calcium concentration using a Ca2+-sensi...

US Patent US9434711 (2016)


BindingDB Entry DOI: 10.7270/Q2H41QB6
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein


(Canis lupus familiaris (Dog))		BDBM248480
PNG
(US9434711, 361)
Show SMILES CC(C)(O)c1c(sc2ccccc12)N(Cc1ccc(F)c(c1)C(F)(F)F)S(=O)(=O)c1ccc(cc1)C(O)=O
Show InChI InChI=1S/C26H21F4NO5S2/c1-25(2,34)22-18-5-3-4-6-21(18)37-23(22)31(14-15-7-12-20(27)19(13-15)26(28,29)30)38(35,36)17-10-8-16(9-11-17)24(32)33/h3-13,34H,14H2,1-2H3,(H,32,33)
PDB

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n/an/a 0.800n/an/an/an/an/a37



Janssen Pharmaceutica, N.V.

US Patent


Assay Description
The functional activity of compounds of the formula (I) was determined by measuring changes in intracellular calcium concentration using a Ca2+-sensi...

US Patent US9434711 (2016)


BindingDB Entry DOI: 10.7270/Q2H41QB6
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein


(Canis lupus familiaris (Dog))		BDBM248583
PNG
(US9434711, 496)
Show SMILES Cc1c(sc2ccccc12)N(Cc1ccc(OC(F)(F)F)cc1)S(=O)(=O)c1ccc(cc1)C(O)=O
Show InChI InChI=1S/C24H18F3NO5S2/c1-15-20-4-2-3-5-21(20)34-22(15)28(14-16-6-10-18(11-7-16)33-24(25,26)27)35(31,32)19-12-8-17(9-13-19)23(29)30/h2-13H,14H2,1H3,(H,29,30)
PDB

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Janssen Pharmaceutica, N.V.

US Patent


Assay Description
The functional activity of compounds of the formula (I) was determined by measuring changes in intracellular calcium concentration using a Ca2+-sensi...

US Patent US9434711 (2016)


BindingDB Entry DOI: 10.7270/Q2H41QB6
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein


(Canis lupus familiaris (Dog))		BDBM248580
PNG
(US9434711, 493)
Show SMILES Cc1c(sc2ccccc12)N(Cc1c(F)c(F)c(F)c(F)c1F)S(=O)(=O)c1ccc(cc1)C(O)=O
Show InChI InChI=1S/C23H14F5NO4S2/c1-11-14-4-2-3-5-16(14)34-22(11)29(10-15-17(24)19(26)21(28)20(27)18(15)25)35(32,33)13-8-6-12(7-9-13)23(30)31/h2-9H,10H2,1H3,(H,30,31)
PDB

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Janssen Pharmaceutica, N.V.

US Patent


Assay Description
The functional activity of compounds of the formula (I) was determined by measuring changes in intracellular calcium concentration using a Ca2+-sensi...

US Patent US9434711 (2016)


BindingDB Entry DOI: 10.7270/Q2H41QB6
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein


(Canis lupus familiaris (Dog))		BDBM248789
PNG
(US9434711, 755)
Show SMILES OC(=O)c1ccc(cc1)S(=O)(=O)N(Cc1ccc(OC(F)(F)F)cc1)c1sc2ccccc2c1C1CC1
Show InChI InChI=1S/C26H20F3NO5S2/c27-26(28,29)35-19-11-5-16(6-12-19)15-30(37(33,34)20-13-9-18(10-14-20)25(31)32)24-23(17-7-8-17)21-3-1-2-4-22(21)36-24/h1-6,9-14,17H,7-8,15H2,(H,31,32)
PDB

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Janssen Pharmaceutica, N.V.

US Patent


Assay Description
The functional activity of compounds of the formula (I) was determined by measuring changes in intracellular calcium concentration using a Ca2+-sensi...

US Patent US9434711 (2016)


BindingDB Entry DOI: 10.7270/Q2H41QB6
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein


(Canis lupus familiaris (Dog))		BDBM248389
PNG
(US9434711, 249)
Show SMILES Brc1c(sc2ccccc12)N(CC12CC3CC(CC(C3)C1)C2)S(=O)(=O)c1ccccc1 |TLB:15:16:20:14.19.13,19:14:21:18.20.17,19:18:21:15.14.13,THB:15:14:20:21.16.17|
Show InChI InChI=1S/C25H26BrNO2S2/c26-23-21-8-4-5-9-22(21)30-24(23)27(31(28,29)20-6-2-1-3-7-20)16-25-13-17-10-18(14-25)12-19(11-17)15-25/h1-9,17-19H,10-16H2
PDB

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Janssen Pharmaceutica, N.V.

US Patent


Assay Description
The functional activity of compounds of the formula (I) was determined by measuring changes in intracellular calcium concentration using a Ca2+-sensi...

US Patent US9434711 (2016)


BindingDB Entry DOI: 10.7270/Q2H41QB6
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein


(Canis lupus familiaris (Dog))		BDBM248581
PNG
(US9434711, 494)
Show SMILES Cc1c(sc2ccccc12)N(Cc1ccc(cc1)S(=O)(=O)C(F)(F)F)S(=O)(=O)c1ccc(cc1)C(O)=O
Show InChI InChI=1S/C24H18F3NO6S3/c1-15-20-4-2-3-5-21(20)35-22(15)28(37(33,34)19-12-8-17(9-13-19)23(29)30)14-16-6-10-18(11-7-16)36(31,32)24(25,26)27/h2-13H,14H2,1H3,(H,29,30)
PDB

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Janssen Pharmaceutica, N.V.

US Patent


Assay Description
The functional activity of compounds of the formula (I) was determined by measuring changes in intracellular calcium concentration using a Ca2+-sensi...

US Patent US9434711 (2016)


BindingDB Entry DOI: 10.7270/Q2H41QB6
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein


(Canis lupus familiaris (Dog))		BDBM248578
PNG
(US9434711, 491)
Show SMILES Cc1c(sc2ccccc12)N(Cc1cccc(c1)C(F)(F)F)S(=O)(=O)c1ccc(cc1)C(O)=O
Show InChI InChI=1S/C24H18F3NO4S2/c1-15-20-7-2-3-8-21(20)33-22(15)28(14-16-5-4-6-18(13-16)24(25,26)27)34(31,32)19-11-9-17(10-12-19)23(29)30/h2-13H,14H2,1H3,(H,29,30)
PDB

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Janssen Pharmaceutica, N.V.

US Patent


Assay Description
The functional activity of compounds of the formula (I) was determined by measuring changes in intracellular calcium concentration using a Ca2+-sensi...

US Patent US9434711 (2016)


BindingDB Entry DOI: 10.7270/Q2H41QB6
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein


(Canis lupus familiaris (Dog))		BDBM248575
PNG
(US9434711, 488)
Show SMILES Cc1c(sc2ccccc12)N(Cc1ccc(F)c(F)c1)S(=O)(=O)c1ccc(cc1)C(O)=O
Show InChI InChI=1S/C23H17F2NO4S2/c1-14-18-4-2-3-5-21(18)31-22(14)26(13-15-6-11-19(24)20(25)12-15)32(29,30)17-9-7-16(8-10-17)23(27)28/h2-12H,13H2,1H3,(H,27,28)
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Janssen Pharmaceutica, N.V.

US Patent


Assay Description
The functional activity of compounds of the formula (I) was determined by measuring changes in intracellular calcium concentration using a Ca2+-sensi...

US Patent US9434711 (2016)


BindingDB Entry DOI: 10.7270/Q2H41QB6
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein


(Canis lupus familiaris (Dog))		BDBM248458
PNG
(US9434711, 335)
Show SMILES CC(O)c1c(sc2ccccc12)N(Cc1ccc(F)c(c1)C(F)(F)F)S(=O)(=O)c1ccc(cc1)C(O)=O
Show InChI InChI=1S/C25H19F4NO5S2/c1-14(31)22-18-4-2-3-5-21(18)36-23(22)30(13-15-6-11-20(26)19(12-15)25(27,28)29)37(34,35)17-9-7-16(8-10-17)24(32)33/h2-12,14,31H,13H2,1H3,(H,32,33)
PDB

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Janssen Pharmaceutica, N.V.

US Patent


Assay Description
The functional activity of compounds of the formula (I) was determined by measuring changes in intracellular calcium concentration using a Ca2+-sensi...

US Patent US9434711 (2016)


BindingDB Entry DOI: 10.7270/Q2H41QB6
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein


(Canis lupus familiaris (Dog))		BDBM248367
PNG
(US9434711, 224)
Show SMILES CC(O)c1c(sc2ccccc12)N(Cc1ccc(F)c(c1)C(F)(F)F)S(C)(=O)=O
Show InChI InChI=1S/C19H17F4NO3S2/c1-11(25)17-13-5-3-4-6-16(13)28-18(17)24(29(2,26)27)10-12-7-8-15(20)14(9-12)19(21,22)23/h3-9,11,25H,10H2,1-2H3
PDB

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Janssen Pharmaceutica, N.V.

US Patent


Assay Description
The functional activity of compounds of the formula (I) was determined by measuring changes in intracellular calcium concentration using a Ca2+-sensi...

US Patent US9434711 (2016)


BindingDB Entry DOI: 10.7270/Q2H41QB6
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein


(Canis lupus familiaris (Dog))		BDBM248613
PNG
(US9434711, 535)
Show SMILES CCS(=O)(=O)N(Cc1ccc(F)c(c1)C(F)(F)F)c1sc2ccccc2c1[C@@H](C)O
Show InChI InChI=1S/C20H19F4NO3S2/c1-3-30(27,28)25(11-13-8-9-16(21)15(10-13)20(22,23)24)19-18(12(2)26)14-6-4-5-7-17(14)29-19/h4-10,12,26H,3,11H2,1-2H3/t12-/m1/s1
PDB

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Janssen Pharmaceutica, N.V.

US Patent


Assay Description
The functional activity of compounds of the formula (I) was determined by measuring changes in intracellular calcium concentration using a Ca2+-sensi...

US Patent US9434711 (2016)


BindingDB Entry DOI: 10.7270/Q2H41QB6
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein


(Canis lupus familiaris (Dog))		BDBM248607
PNG
(US9434711, 526)
Show SMILES Cc1c(sc2ccccc12)N(Cc1ccc(SC(F)(F)F)cc1)S(=O)(=O)c1ccc(cc1)C(O)=O
Show InChI InChI=1S/C24H18F3NO4S3/c1-15-20-4-2-3-5-21(20)33-22(15)28(14-16-6-10-18(11-7-16)34-24(25,26)27)35(31,32)19-12-8-17(9-13-19)23(29)30/h2-13H,14H2,1H3,(H,29,30)
PDB

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n/an/a 1n/an/an/an/an/a37



Janssen Pharmaceutica, N.V.

US Patent


Assay Description
The functional activity of compounds of the formula (I) was determined by measuring changes in intracellular calcium concentration using a Ca2+-sensi...

US Patent US9434711 (2016)


BindingDB Entry DOI: 10.7270/Q2H41QB6
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein


(Canis lupus familiaris (Dog))		BDBM248840
PNG
(US9434711, 810)
Show SMILES Cc1c(sc2ccccc12)N(Cc1ccc(OC(F)(F)F)cc1)S(=O)(=O)c1ccc(cc1)-c1nsc(=O)[nH]1
Show InChI InChI=1S/C25H18F3N3O4S3/c1-15-20-4-2-3-5-21(20)36-23(15)31(14-16-6-10-18(11-7-16)35-25(26,27)28)38(33,34)19-12-8-17(9-13-19)22-29-24(32)37-30-22/h2-13H,14H2,1H3,(H,29,30,32)
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Janssen Pharmaceutica, N.V.

US Patent


Assay Description
The functional activity of compounds of the formula (I) was determined by measuring changes in intracellular calcium concentration using a Ca2+-sensi...

US Patent US9434711 (2016)


BindingDB Entry DOI: 10.7270/Q2H41QB6
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein


(Canis lupus familiaris (Dog))		BDBM248577
PNG
(US9434711, 490)
Show SMILES Cc1c(sc2ccccc12)N(Cc1ccc(OC(F)F)cc1)S(=O)(=O)c1ccc(cc1)C(O)=O
Show InChI InChI=1S/C24H19F2NO5S2/c1-15-20-4-2-3-5-21(20)33-22(15)27(14-16-6-10-18(11-7-16)32-24(25)26)34(30,31)19-12-8-17(9-13-19)23(28)29/h2-13,24H,14H2,1H3,(H,28,29)
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Janssen Pharmaceutica, N.V.

US Patent


Assay Description
The functional activity of compounds of the formula (I) was determined by measuring changes in intracellular calcium concentration using a Ca2+-sensi...

US Patent US9434711 (2016)


BindingDB Entry DOI: 10.7270/Q2H41QB6
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein


(Canis lupus familiaris (Dog))		BDBM248414
PNG
(US9434711, 278)
Show SMILES OC(=O)c1ccc(cc1)S(=O)(=O)N(CC12CC3CC(CC(C3)C1)C2)c1sc2ccccc2c1Br |TLB:17:18:22:16.21.15,21:16:23:20.22.19,21:20:23:17.16.15,THB:17:16:22:23.18.19|
Show InChI InChI=1S/C26H26BrNO4S2/c27-23-21-3-1-2-4-22(21)33-24(23)28(34(31,32)20-7-5-19(6-8-20)25(29)30)15-26-12-16-9-17(13-26)11-18(10-16)14-26/h1-8,16-18H,9-15H2,(H,29,30)
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Janssen Pharmaceutica, N.V.

US Patent


Assay Description
The functional activity of compounds of the formula (I) was determined by measuring changes in intracellular calcium concentration using a Ca2+-sensi...

US Patent US9434711 (2016)


BindingDB Entry DOI: 10.7270/Q2H41QB6
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein


(Canis lupus familiaris (Dog))		BDBM248361
PNG
(US9434711, 218)
Show SMILES OCc1c(sc2ccccc12)N(Cc1ccc(F)c(c1)C(F)(F)F)S(=O)(=O)c1ccc(cc1)C(O)=O
Show InChI InChI=1S/C24H17F4NO5S2/c25-20-10-5-14(11-19(20)24(26,27)28)12-29(22-18(13-30)17-3-1-2-4-21(17)35-22)36(33,34)16-8-6-15(7-9-16)23(31)32/h1-11,30H,12-13H2,(H,31,32)
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Janssen Pharmaceutica, N.V.

US Patent


Assay Description
The functional activity of compounds of the formula (I) was determined by measuring changes in intracellular calcium concentration using a Ca2+-sensi...

US Patent US9434711 (2016)


BindingDB Entry DOI: 10.7270/Q2H41QB6
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein


(Canis lupus familiaris (Dog))		BDBM50426573
PNG
(CHEMBL2324349 | US9434711, 306)
Show SMILES Cc1c(sc2ccccc12)N(Cc1ccc(F)c(c1)C(F)(F)F)S(=O)(=O)c1ccc(cc1)C(O)=O
Show InChI InChI=1S/C24H17F4NO4S2/c1-14-18-4-2-3-5-21(18)34-22(14)29(13-15-6-11-20(25)19(12-15)24(26,27)28)35(32,33)17-9-7-16(8-10-17)23(30)31/h2-12H,13H2,1H3,(H,30,31)
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Janssen Pharmaceutica, N.V.

US Patent


Assay Description
For patch clamp experiments, HEK293 cells are stably transfected with canine TRPM8 and cultured in DMEM supplemented with 10% fetal bovine serum, 100...

US Patent US9434711 (2016)


BindingDB Entry DOI: 10.7270/Q2H41QB6
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein


(Canis lupus familiaris (Dog))		BDBM248363
PNG
(US9434711, 220)
Show SMILES CCS(=O)(=O)N(Cc1ccc(F)c(c1)C(F)(F)F)c1sc2ccccc2c1C(C)O
Show InChI InChI=1S/C20H19F4NO3S2/c1-3-30(27,28)25(11-13-8-9-16(21)15(10-13)20(22,23)24)19-18(12(2)26)14-6-4-5-7-17(14)29-19/h4-10,12,26H,3,11H2,1-2H3
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Janssen Pharmaceutica, N.V.

US Patent


Assay Description
The functional activity of compounds of the formula (I) was determined by measuring changes in intracellular calcium concentration using a Ca2+-sensi...

US Patent US9434711 (2016)


BindingDB Entry DOI: 10.7270/Q2H41QB6
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein


(Canis lupus familiaris (Dog))		BDBM248415
PNG
(US9434711, 279)
Show SMILES OC(=O)c1ccc(cc1)S(=O)(=O)N(CC1CCCCC1)c1sc2ccccc2c1Br
Show InChI InChI=1S/C22H22BrNO4S2/c23-20-18-8-4-5-9-19(18)29-21(20)24(14-15-6-2-1-3-7-15)30(27,28)17-12-10-16(11-13-17)22(25)26/h4-5,8-13,15H,1-3,6-7,14H2,(H,25,26)
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Janssen Pharmaceutica, N.V.

US Patent


Assay Description
The functional activity of compounds of the formula (I) was determined by measuring changes in intracellular calcium concentration using a Ca2+-sensi...

US Patent US9434711 (2016)


BindingDB Entry DOI: 10.7270/Q2H41QB6
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein


(Canis lupus familiaris (Dog))		BDBM248808
PNG
(US9434711, 774)
Show SMILES Cc1c(sc2ccccc12)N(Cc1ccc(OC(F)(F)F)cc1)S(=O)(=O)c1ccc(C(O)=O)c(F)c1
Show InChI InChI=1S/C24H17F4NO5S2/c1-14-18-4-2-3-5-21(18)35-22(14)29(13-15-6-8-16(9-7-15)34-24(26,27)28)36(32,33)17-10-11-19(23(30)31)20(25)12-17/h2-12H,13H2,1H3,(H,30,31)
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Janssen Pharmaceutica, N.V.

US Patent


Assay Description
The functional activity of compounds of the formula (I) was determined by measuring changes in intracellular calcium concentration using a Ca2+-sensi...

US Patent US9434711 (2016)


BindingDB Entry DOI: 10.7270/Q2H41QB6
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein


(Canis lupus familiaris (Dog))		BDBM248790
PNG
(US9434711, 756)
Show SMILES OC(=O)c1ccc(cc1)S(=O)(=O)N(Cc1ccc(OC(F)(F)F)cc1)c1sc2ccccc2c1C1CCC1
Show InChI InChI=1S/C27H22F3NO5S2/c28-27(29,30)36-20-12-8-17(9-13-20)16-31(38(34,35)21-14-10-19(11-15-21)26(32)33)25-24(18-4-3-5-18)22-6-1-2-7-23(22)37-25/h1-2,6-15,18H,3-5,16H2,(H,32,33)
PDB

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Janssen Pharmaceutica, N.V.

US Patent


Assay Description
The functional activity of compounds of the formula (I) was determined by measuring changes in intracellular calcium concentration using a Ca2+-sensi...

US Patent US9434711 (2016)


BindingDB Entry DOI: 10.7270/Q2H41QB6
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8


(Homo sapiens (Human))		BDBM248583
PNG
(US9434711, 496)
Show SMILES Cc1c(sc2ccccc12)N(Cc1ccc(OC(F)(F)F)cc1)S(=O)(=O)c1ccc(cc1)C(O)=O
Show InChI InChI=1S/C24H18F3NO5S2/c1-15-20-4-2-3-5-21(20)34-22(15)28(14-16-6-10-18(11-7-16)33-24(25,26)27)35(31,32)19-12-8-17(9-13-19)23(29)30/h2-13H,14H2,1H3,(H,29,30)
PDB

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Janssen Pharmaceutica, N.V.

US Patent


Assay Description
For functional expression of TRPM8, the full-length cDNA encoding human and rat TRPM8 are subcloned into pCI-NEO mammalian expression vectors. The ex...

US Patent US9434711 (2016)


BindingDB Entry DOI: 10.7270/Q2H41QB6
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein


(Canis lupus familiaris (Dog))		BDBM248356
PNG
(US9434711, 213)
Show SMILES OCc1c(sc2ccccc12)N(Cc1ccc(F)c(F)c1)S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C22H17F2NO3S2/c23-19-11-10-15(12-20(19)24)13-25(30(27,28)16-6-2-1-3-7-16)22-18(14-26)17-8-4-5-9-21(17)29-22/h1-12,26H,13-14H2
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Janssen Pharmaceutica, N.V.

US Patent


Assay Description
The functional activity of compounds of the formula (I) was determined by measuring changes in intracellular calcium concentration using a Ca2+-sensi...

US Patent US9434711 (2016)


BindingDB Entry DOI: 10.7270/Q2H41QB6
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein


(Canis lupus familiaris (Dog))		BDBM248809
PNG
(US9434711, 775)
Show SMILES Cc1c(sc2ccccc12)N(Cc1ccc(F)c(c1)C(F)(F)F)S(=O)(=O)c1ccc(C(O)=O)c(F)c1
Show InChI InChI=1S/C24H16F5NO4S2/c1-13-16-4-2-3-5-21(16)35-22(13)30(12-14-6-9-19(25)18(10-14)24(27,28)29)36(33,34)15-7-8-17(23(31)32)20(26)11-15/h2-11H,12H2,1H3,(H,31,32)
PDB

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Janssen Pharmaceutica, N.V.

US Patent


Assay Description
The functional activity of compounds of the formula (I) was determined by measuring changes in intracellular calcium concentration using a Ca2+-sensi...

US Patent US9434711 (2016)


BindingDB Entry DOI: 10.7270/Q2H41QB6
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein


(Canis lupus familiaris (Dog))		BDBM248365
PNG
(US9434711, 222)
Show SMILES CC(O)c1c(sc2ccccc12)N(Cc1ccc(F)c(F)c1)S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C23H19F2NO3S2/c1-15(27)22-18-9-5-6-10-21(18)30-23(22)26(14-16-11-12-19(24)20(25)13-16)31(28,29)17-7-3-2-4-8-17/h2-13,15,27H,14H2,1H3
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Janssen Pharmaceutica, N.V.

US Patent


Assay Description
The functional activity of compounds of the formula (I) was determined by measuring changes in intracellular calcium concentration using a Ca2+-sensi...

US Patent US9434711 (2016)


BindingDB Entry DOI: 10.7270/Q2H41QB6
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein


(Canis lupus familiaris (Dog))		BDBM248428
PNG
(US9434711, 294)
Show SMILES OC(=O)c1ccc(cc1)S(=O)(=O)N(Cc1ccc(F)c(c1)C(F)(F)F)c1sc2ccccc2c1Cl
Show InChI InChI=1S/C23H14ClF4NO4S2/c24-20-16-3-1-2-4-19(16)34-21(20)29(12-13-5-10-18(25)17(11-13)23(26,27)28)35(32,33)15-8-6-14(7-9-15)22(30)31/h1-11H,12H2,(H,30,31)
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Janssen Pharmaceutica, N.V.

US Patent


Assay Description
The functional activity of compounds of the formula (I) was determined by measuring changes in intracellular calcium concentration using a Ca2+-sensi...

US Patent US9434711 (2016)


BindingDB Entry DOI: 10.7270/Q2H41QB6
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8


(Rattus norvegicus (Rat))		BDBM248583
PNG
(US9434711, 496)
Show SMILES Cc1c(sc2ccccc12)N(Cc1ccc(OC(F)(F)F)cc1)S(=O)(=O)c1ccc(cc1)C(O)=O
Show InChI InChI=1S/C24H18F3NO5S2/c1-15-20-4-2-3-5-21(20)34-22(15)28(14-16-6-10-18(11-7-16)33-24(25,26)27)35(31,32)19-12-8-17(9-13-19)23(29)30/h2-13H,14H2,1H3,(H,29,30)
PDB

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Janssen Pharmaceutica, N.V.

US Patent


Assay Description
For functional expression of TRPM8, the full-length cDNA encoding human and rat TRPM8 are subcloned into pCI-NEO mammalian expression vectors. The ex...

US Patent US9434711 (2016)


BindingDB Entry DOI: 10.7270/Q2H41QB6
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein


(Canis lupus familiaris (Dog))		BDBM248640
PNG
(US9434711, 566)
Show SMILES CC(C)c1c(sc2ccccc12)N(Cc1ccc(F)c(c1)C(F)(F)F)S(=O)(=O)c1ccc(cc1)C(O)=O
Show InChI InChI=1S/C26H21F4NO4S2/c1-15(2)23-19-5-3-4-6-22(19)36-24(23)31(14-16-7-12-21(27)20(13-16)26(28,29)30)37(34,35)18-10-8-17(9-11-18)25(32)33/h3-13,15H,14H2,1-2H3,(H,32,33)
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Janssen Pharmaceutica, N.V.

US Patent


Assay Description
The functional activity of compounds of the formula (I) was determined by measuring changes in intracellular calcium concentration using a Ca2+-sensi...

US Patent US9434711 (2016)


BindingDB Entry DOI: 10.7270/Q2H41QB6
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein


(Canis lupus familiaris (Dog))		BDBM248662
PNG
(US9434711, 592)
Show SMILES Cc1c(sc2ccccc12)N(Cc1ccc(F)c(c1)C(F)(F)F)S(=O)(=O)c1ccc(cc1F)C(O)=O
Show InChI InChI=1S/C24H16F5NO4S2/c1-13-16-4-2-3-5-20(16)35-22(13)30(12-14-6-8-18(25)17(10-14)24(27,28)29)36(33,34)21-9-7-15(23(31)32)11-19(21)26/h2-11H,12H2,1H3,(H,31,32)
PDB

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Janssen Pharmaceutica, N.V.

US Patent


Assay Description
The functional activity of compounds of the formula (I) was determined by measuring changes in intracellular calcium concentration using a Ca2+-sensi...

US Patent US9434711 (2016)


BindingDB Entry DOI: 10.7270/Q2H41QB6
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein


(Canis lupus familiaris (Dog))		BDBM248622
PNG
(US9434711, 544)
Show SMILES Cc1c(sc2ccccc12)N(Cc1ccc(F)c(c1)C(F)(F)F)S(=O)(=O)c1ccc(cc1)-c1noc(=O)[nH]1
Show InChI InChI=1S/C25H17F4N3O4S2/c1-14-18-4-2-3-5-21(18)37-23(14)32(13-15-6-11-20(26)19(12-15)25(27,28)29)38(34,35)17-9-7-16(8-10-17)22-30-24(33)36-31-22/h2-12H,13H2,1H3,(H,30,31,33)
PDB

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Janssen Pharmaceutica, N.V.

US Patent


Assay Description
The functional activity of compounds of the formula (I) was determined by measuring changes in intracellular calcium concentration using a Ca2+-sensi...

US Patent US9434711 (2016)


BindingDB Entry DOI: 10.7270/Q2H41QB6
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein


(Canis lupus familiaris (Dog))		BDBM248623
PNG
(US9434711, 545)
Show SMILES Cc1c(sc2ccccc12)N(CCCCC(F)(F)F)S(=O)(=O)c1ccc(cc1)C(O)=O
Show InChI InChI=1S/C21H20F3NO4S2/c1-14-17-6-2-3-7-18(17)30-19(14)25(13-5-4-12-21(22,23)24)31(28,29)16-10-8-15(9-11-16)20(26)27/h2-3,6-11H,4-5,12-13H2,1H3,(H,26,27)
PDB

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Janssen Pharmaceutica, N.V.

US Patent


Assay Description
The functional activity of compounds of the formula (I) was determined by measuring changes in intracellular calcium concentration using a Ca2+-sensi...

US Patent US9434711 (2016)


BindingDB Entry DOI: 10.7270/Q2H41QB6
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein


(Canis lupus familiaris (Dog))		BDBM248746
PNG
(US9434711, 698)
Show SMILES OC(=O)c1ccc(cc1)S(=O)(=O)N(Cc1ccc(F)c(c1)C(F)(F)F)c1sc2ccccc2c1C1CCC1
Show InChI InChI=1S/C27H21F4NO4S2/c28-22-13-8-16(14-21(22)27(29,30)31)15-32(38(35,36)19-11-9-18(10-12-19)26(33)34)25-24(17-4-3-5-17)20-6-1-2-7-23(20)37-25/h1-2,6-14,17H,3-5,15H2,(H,33,34)
PDB

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Janssen Pharmaceutica, N.V.

US Patent


Assay Description
The functional activity of compounds of the formula (I) was determined by measuring changes in intracellular calcium concentration using a Ca2+-sensi...

US Patent US9434711 (2016)


BindingDB Entry DOI: 10.7270/Q2H41QB6
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein


(Canis lupus familiaris (Dog))		BDBM248292
PNG
(US9434711, 140)
Show SMILES Fc1ccc(CN(c2sc3ccccc3c2Br)S(=O)(=O)c2ccccc2)cc1
Show InChI InChI=1S/C21H15BrFNO2S2/c22-20-18-8-4-5-9-19(18)27-21(20)24(14-15-10-12-16(23)13-11-15)28(25,26)17-6-2-1-3-7-17/h1-13H,14H2
PDB

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UniProtKB/TrEMBL

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UniChem
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n/an/a 2n/an/an/an/an/a37



Janssen Pharmaceutica, N.V.

US Patent


Assay Description
The functional activity of compounds of the formula (I) was determined by measuring changes in intracellular calcium concentration using a Ca2+-sensi...

US Patent US9434711 (2016)


BindingDB Entry DOI: 10.7270/Q2H41QB6
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein


(Canis lupus familiaris (Dog))		BDBM248549
PNG
(US9434711, 453)
Show SMILES OC(=O)c1ccc(cc1)S(=O)(=O)N(CCOC1CCCCC1)c1sc2ccccc2c1Br
Show InChI InChI=1S/C23H24BrNO5S2/c24-21-19-8-4-5-9-20(19)31-22(21)25(14-15-30-17-6-2-1-3-7-17)32(28,29)18-12-10-16(11-13-18)23(26)27/h4-5,8-13,17H,1-3,6-7,14-15H2,(H,26,27)
PDB

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n/an/a 2n/an/an/an/an/a37



Janssen Pharmaceutica, N.V.

US Patent


Assay Description
The functional activity of compounds of the formula (I) was determined by measuring changes in intracellular calcium concentration using a Ca2+-sensi...

US Patent US9434711 (2016)


BindingDB Entry DOI: 10.7270/Q2H41QB6
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein


(Canis lupus familiaris (Dog))		BDBM248236
PNG
(US9434711, 68)
Show SMILES CN1CCOc2cc(ccc12)S(=O)(=O)N(Cc1ccc(F)c(c1)C(F)(F)F)c1sc2ccccc2c1C
Show InChI InChI=1S/C26H22F4N2O3S2/c1-16-19-5-3-4-6-24(19)36-25(16)32(15-17-7-9-21(27)20(13-17)26(28,29)30)37(33,34)18-8-10-22-23(14-18)35-12-11-31(22)2/h3-10,13-14H,11-12,15H2,1-2H3
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n/an/a 2n/an/an/an/an/a37



Janssen Pharmaceutica, N.V.

US Patent


Assay Description
The functional activity of compounds of the formula (I) was determined by measuring changes in intracellular calcium concentration using a Ca2+-sensi...

US Patent US9434711 (2016)


BindingDB Entry DOI: 10.7270/Q2H41QB6
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein


(Canis lupus familiaris (Dog))		BDBM248612
PNG
(US9434711, 534)
Show SMILES CCS(=O)(=O)N(Cc1ccc(F)c(c1)C(F)(F)F)c1sc2ccccc2c1[C@H](C)O
Show InChI InChI=1S/C20H19F4NO3S2/c1-3-30(27,28)25(11-13-8-9-16(21)15(10-13)20(22,23)24)19-18(12(2)26)14-6-4-5-7-17(14)29-19/h4-10,12,26H,3,11H2,1-2H3/t12-/m0/s1
PDB

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n/an/a 2n/an/an/an/an/a37



Janssen Pharmaceutica, N.V.

US Patent


Assay Description
The functional activity of compounds of the formula (I) was determined by measuring changes in intracellular calcium concentration using a Ca2+-sensi...

US Patent US9434711 (2016)


BindingDB Entry DOI: 10.7270/Q2H41QB6
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein


(Canis lupus familiaris (Dog))		BDBM248574
PNG
(US9434711, 487)
Show SMILES Cc1c(sc2ccccc12)N(Cc1ccc(F)cc1)S(=O)(=O)c1ccc(cc1)C(O)=O
Show InChI InChI=1S/C23H18FNO4S2/c1-15-20-4-2-3-5-21(20)30-22(15)25(14-16-6-10-18(24)11-7-16)31(28,29)19-12-8-17(9-13-19)23(26)27/h2-13H,14H2,1H3,(H,26,27)
PDB

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n/an/a 2n/an/an/an/an/a37



Janssen Pharmaceutica, N.V.

US Patent


Assay Description
The functional activity of compounds of the formula (I) was determined by measuring changes in intracellular calcium concentration using a Ca2+-sensi...

US Patent US9434711 (2016)


BindingDB Entry DOI: 10.7270/Q2H41QB6
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein


(Canis lupus familiaris (Dog))		BDBM248602
PNG
(US9434711, 521)
Show SMILES Cc1c(sc2ccccc12)N(Cc1ccc(Cl)c(F)c1)S(=O)(=O)c1ccc(cc1)C(O)=O
Show InChI InChI=1S/C23H17ClFNO4S2/c1-14-18-4-2-3-5-21(18)31-22(14)26(13-15-6-11-19(24)20(25)12-15)32(29,30)17-9-7-16(8-10-17)23(27)28/h2-12H,13H2,1H3,(H,27,28)
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n/an/a 2n/an/an/an/an/a37



Janssen Pharmaceutica, N.V.

US Patent


Assay Description
The functional activity of compounds of the formula (I) was determined by measuring changes in intracellular calcium concentration using a Ca2+-sensi...

US Patent US9434711 (2016)


BindingDB Entry DOI: 10.7270/Q2H41QB6
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein


(Canis lupus familiaris (Dog))		BDBM248537
PNG
(US9434711, 438)
Show SMILES OC(=O)c1ccc(cc1)S(=O)(=O)N(CC1CCCC1)c1sc2ccccc2c1Br
Show InChI InChI=1S/C21H20BrNO4S2/c22-19-17-7-3-4-8-18(17)28-20(19)23(13-14-5-1-2-6-14)29(26,27)16-11-9-15(10-12-16)21(24)25/h3-4,7-12,14H,1-2,5-6,13H2,(H,24,25)
PDB

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n/an/a 2n/an/an/an/an/a37



Janssen Pharmaceutica, N.V.

US Patent


Assay Description
The functional activity of compounds of the formula (I) was determined by measuring changes in intracellular calcium concentration using a Ca2+-sensi...

US Patent US9434711 (2016)


BindingDB Entry DOI: 10.7270/Q2H41QB6
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein


(Canis lupus familiaris (Dog))		BDBM248430
PNG
(US9434711, 296)
Show SMILES OC(=O)c1ccc(cc1)S(=O)(=O)N(Cc1ccc(F)c(c1)C(F)(F)F)c1cc2ccccc2s1
Show InChI InChI=1S/C23H15F4NO4S2/c24-19-10-5-14(11-18(19)23(25,26)27)13-28(21-12-16-3-1-2-4-20(16)33-21)34(31,32)17-8-6-15(7-9-17)22(29)30/h1-12H,13H2,(H,29,30)
PDB

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n/an/a 2n/an/an/an/an/a37



Janssen Pharmaceutica, N.V.

US Patent


Assay Description
The functional activity of compounds of the formula (I) was determined by measuring changes in intracellular calcium concentration using a Ca2+-sensi...

US Patent US9434711 (2016)


BindingDB Entry DOI: 10.7270/Q2H41QB6
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein


(Canis lupus familiaris (Dog))		BDBM248564
PNG
(US9434711, 475)
Show SMILES Fc1ccc(CN(c2sc3ccccc3c2Br)S(=O)(=O)c2ccc(cc2)-c2nnn[nH]2)cc1C(F)(F)F
Show InChI InChI=1S/C23H14BrF4N5O2S2/c24-20-16-3-1-2-4-19(16)36-22(20)33(12-13-5-10-18(25)17(11-13)23(26,27)28)37(34,35)15-8-6-14(7-9-15)21-29-31-32-30-21/h1-11H,12H2,(H,29,30,31,32)
PDB

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Janssen Pharmaceutica, N.V.

US Patent


Assay Description
The functional activity of compounds of the formula (I) was determined by measuring changes in intracellular calcium concentration using a Ca2+-sensi...

US Patent US9434711 (2016)


BindingDB Entry DOI: 10.7270/Q2H41QB6
More data for this
Ligand-Target Pair
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* indicates data uncertainty>20%