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USPatent US9475806

Compile data set for download or QSAR
Found 21 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Complement factor B


(Homo sapiens (Human))
BDBM251874
PNG
(US9475806, 8-B b) (-))
Show SMILES COc1cc(C)c2[nH]ccc2c1C(C)(OC)c1nc2cc(cnc2[nH]1)C#N
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 30n/an/an/an/a7.425



Novartis AG

US Patent


Assay Description
Recombinant human factor B (expressed in drosophila cells and purified using standard methods) labeled with biotin (10 nM), europium-labeled streptav...


US Patent US9475806 (2016)


BindingDB Entry DOI: 10.7270/Q2KS6QG2
More data for this
Ligand-Target Pair
Complement factor B


(Homo sapiens (Human))
BDBM251876
PNG
(US9475806, 9-D b) (-))
Show SMILES CNC(c1nc2cc(cnc2[nH]1)C#N)(c1c(OC)cc(C)c2[nH]ccc12)C(F)(F)F
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 30n/an/an/an/a7.425



Novartis AG

US Patent


Assay Description
Recombinant human factor B (expressed in drosophila cells and purified using standard methods) labeled with biotin (10 nM), europium-labeled streptav...


US Patent US9475806 (2016)


BindingDB Entry DOI: 10.7270/Q2KS6QG2
More data for this
Ligand-Target Pair
Complement factor B


(Homo sapiens (Human))
BDBM251882
PNG
(US9475806, 12-D)
Show SMILES COc1cc(C)c2[nH]ccc2c1C(C)(C)c1nc2cc(cnc2[nH]1)C#N
Show InChI InChI=1S/C20H19N5O/c1-11-7-15(26-4)16(13-5-6-22-17(11)13)20(2,3)19-24-14-8-12(9-21)10-23-18(14)25-19/h5-8,10,22H,1-4H3,(H,23,24,25)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 40n/an/an/an/a7.425



Novartis AG

US Patent


Assay Description
Recombinant human factor B (expressed in drosophila cells and purified using standard methods) labeled with biotin (10 nM), europium-labeled streptav...


US Patent US9475806 (2016)


BindingDB Entry DOI: 10.7270/Q2KS6QG2
More data for this
Ligand-Target Pair
Complement factor B


(Homo sapiens (Human))
BDBM251878
PNG
(US9475806, 10-B b) (-))
Show SMILES COc1cc(C)c2[nH]ccc2c1C(C)(N)c1nc2cc(cnc2[nH]1)C#N
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 40n/an/an/an/a7.425



Novartis AG

US Patent


Assay Description
Recombinant human factor B (expressed in drosophila cells and purified using standard methods) labeled with biotin (10 nM), europium-labeled streptav...


US Patent US9475806 (2016)


BindingDB Entry DOI: 10.7270/Q2KS6QG2
More data for this
Ligand-Target Pair
Complement factor B


(Homo sapiens (Human))
BDBM251873
PNG
(US9475806, 7-D b) (+))
Show SMILES COc1cc(C)c2[nH]ccc2c1C(C)(O)c1nc2cc(cnc2[nH]1)C#N
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 50n/an/an/an/a7.425



Novartis AG

US Patent


Assay Description
Recombinant human factor B (expressed in drosophila cells and purified using standard methods) labeled with biotin (10 nM), europium-labeled streptav...


US Patent US9475806 (2016)


BindingDB Entry DOI: 10.7270/Q2KS6QG2
More data for this
Ligand-Target Pair
Complement factor B


(Homo sapiens (Human))
BDBM251887
PNG
(US9475806, 17-C)
Show SMILES Cc1cc(C2CC2)c(c2cc[nH]c12)C(C)(O)c1nc2cc(cnc2[nH]1)C#N
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 60n/an/an/an/a7.425



Novartis AG

US Patent


Assay Description
Recombinant human factor B (expressed in drosophila cells and purified using standard methods) labeled with biotin (10 nM), europium-labeled streptav...


US Patent US9475806 (2016)


BindingDB Entry DOI: 10.7270/Q2KS6QG2
More data for this
Ligand-Target Pair
Complement factor B


(Homo sapiens (Human))
BDBM251870
PNG
(US9475806, 6-C b) (-))
Show SMILES COc1cc(C)c2[nH]ccc2c1C(O)c1nc2ncc(cc2[nH]1)C#N
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 90n/an/an/an/a7.425



Novartis AG

US Patent


Assay Description
Recombinant human factor B (expressed in drosophila cells and purified using standard methods) labeled with biotin (10 nM), europium-labeled streptav...


US Patent US9475806 (2016)


BindingDB Entry DOI: 10.7270/Q2KS6QG2
More data for this
Ligand-Target Pair
Complement factor B


(Homo sapiens (Human))
BDBM251888
PNG
(US9475806, 17-G)
Show SMILES Cc1cc(C2CC2)c(c2cc[nH]c12)C(N)(c1nc2cc(cnc2[nH]1)C#N)C(F)(F)F
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 90n/an/an/an/a7.425



Novartis AG

US Patent


Assay Description
Recombinant human factor B (expressed in drosophila cells and purified using standard methods) labeled with biotin (10 nM), europium-labeled streptav...


US Patent US9475806 (2016)


BindingDB Entry DOI: 10.7270/Q2KS6QG2
More data for this
Ligand-Target Pair
Complement factor B


(Homo sapiens (Human))
BDBM251883
PNG
(US9475806, 14-I b) (-))
Show SMILES CCc1cc(C)c2[nH]ccc2c1C(O)(c1nc2cc(cnc2[nH]1)C#N)C(F)(F)F
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 100n/an/an/an/a7.425



Novartis AG

US Patent


Assay Description
Recombinant human factor B (expressed in drosophila cells and purified using standard methods) labeled with biotin (10 nM), europium-labeled streptav...


US Patent US9475806 (2016)


BindingDB Entry DOI: 10.7270/Q2KS6QG2
More data for this
Ligand-Target Pair
Complement factor B


(Homo sapiens (Human))
BDBM251872
PNG
(US9475806, 7-D b) (-))
Show SMILES COc1cc(C)c2[nH]ccc2c1C(C)(O)c1nc2cc(cnc2[nH]1)C#N
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 130n/an/an/an/a7.425



Novartis AG

US Patent


Assay Description
Recombinant human factor B (expressed in drosophila cells and purified using standard methods) labeled with biotin (10 nM), europium-labeled streptav...


US Patent US9475806 (2016)


BindingDB Entry DOI: 10.7270/Q2KS6QG2
More data for this
Ligand-Target Pair
Complement factor B


(Homo sapiens (Human))
BDBM251869
PNG
(US9475806, 5-B b) (-))
Show SMILES COc1cc(C)c2[nH]ccc2c1C(N)(c1nc2cc(cnc2[nH]1)C#N)C(F)(F)F
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 140n/an/an/an/a7.425



Novartis AG

US Patent


Assay Description
Recombinant human factor B (expressed in drosophila cells and purified using standard methods) labeled with biotin (10 nM), europium-labeled streptav...


US Patent US9475806 (2016)


BindingDB Entry DOI: 10.7270/Q2KS6QG2
More data for this
Ligand-Target Pair
Complement factor B


(Homo sapiens (Human))
BDBM251868
PNG
(US9475806, 5-B b) (+))
Show SMILES COc1cc(C)c2[nH]ccc2c1C(N)(c1nc2cc(cnc2[nH]1)C#N)C(F)(F)F
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 290n/an/an/an/a7.425



Novartis AG

US Patent


Assay Description
Recombinant human factor B (expressed in drosophila cells and purified using standard methods) labeled with biotin (10 nM), europium-labeled streptav...


US Patent US9475806 (2016)


BindingDB Entry DOI: 10.7270/Q2KS6QG2
More data for this
Ligand-Target Pair
Complement factor B


(Homo sapiens (Human))
BDBM251880
PNG
(US9475806, 11-B b) (-))
Show SMILES CNC(C)(c1nc2cc(cnc2[nH]1)C#N)c1c(OC)cc(C)c2[nH]ccc12
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 295n/an/an/an/a7.425



Novartis AG

US Patent


Assay Description
Recombinant human factor B (expressed in drosophila cells and purified using standard methods) labeled with biotin (10 nM), europium-labeled streptav...


US Patent US9475806 (2016)


BindingDB Entry DOI: 10.7270/Q2KS6QG2
More data for this
Ligand-Target Pair
Complement factor B


(Homo sapiens (Human))
BDBM251886
PNG
(US9475806, 16-G)
Show SMILES Cc1cc(C2CC2)c(C(O)c2nc3cc(cnc3[nH]2)C#N)c2cc[nH]c12
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 460n/an/an/an/a7.425



Novartis AG

US Patent


Assay Description
Recombinant human factor B (expressed in drosophila cells and purified using standard methods) labeled with biotin (10 nM), europium-labeled streptav...


US Patent US9475806 (2016)


BindingDB Entry DOI: 10.7270/Q2KS6QG2
More data for this
Ligand-Target Pair
Complement factor B


(Homo sapiens (Human))
BDBM251885
PNG
(US9475806, 15-D)
Show SMILES CCc1cc(C)c2[nH]ccc2c1C(C)(NC)c1nc2cc(cnc2[nH]1)C#N
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 540n/an/an/an/a7.425



Novartis AG

US Patent


Assay Description
Recombinant human factor B (expressed in drosophila cells and purified using standard methods) labeled with biotin (10 nM), europium-labeled streptav...


US Patent US9475806 (2016)


BindingDB Entry DOI: 10.7270/Q2KS6QG2
More data for this
Ligand-Target Pair
Complement factor B


(Homo sapiens (Human))
BDBM251871
PNG
(US9475806, 6-C b) (+))
Show SMILES COc1cc(C)c2[nH]ccc2c1C(O)c1nc2ncc(cc2[nH]1)C#N
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 700n/an/an/an/a7.425



Novartis AG

US Patent


Assay Description
Recombinant human factor B (expressed in drosophila cells and purified using standard methods) labeled with biotin (10 nM), europium-labeled streptav...


US Patent US9475806 (2016)


BindingDB Entry DOI: 10.7270/Q2KS6QG2
More data for this
Ligand-Target Pair
Complement factor B


(Homo sapiens (Human))
BDBM251875
PNG
(US9475806, 8-B b) (+))
Show SMILES COc1cc(C)c2[nH]ccc2c1C(C)(OC)c1nc2cc(cnc2[nH]1)C#N
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 720n/an/an/an/a7.425



Novartis AG

US Patent


Assay Description
Recombinant human factor B (expressed in drosophila cells and purified using standard methods) labeled with biotin (10 nM), europium-labeled streptav...


US Patent US9475806 (2016)


BindingDB Entry DOI: 10.7270/Q2KS6QG2
More data for this
Ligand-Target Pair
Complement factor B


(Homo sapiens (Human))
BDBM251879
PNG
(US9475806, 10-B b) (+))
Show SMILES COc1cc(C)c2[nH]ccc2c1C(C)(N)c1nc2cc(cnc2[nH]1)C#N
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 1.38E+3n/an/an/an/a7.425



Novartis AG

US Patent


Assay Description
Recombinant human factor B (expressed in drosophila cells and purified using standard methods) labeled with biotin (10 nM), europium-labeled streptav...


US Patent US9475806 (2016)


BindingDB Entry DOI: 10.7270/Q2KS6QG2
More data for this
Ligand-Target Pair
Complement factor B


(Homo sapiens (Human))
BDBM251877
PNG
(US9475806, 9-D b) (+))
Show SMILES CNC(c1nc2cc(cnc2[nH]1)C#N)(c1c(OC)cc(C)c2[nH]ccc12)C(F)(F)F
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 1.53E+3n/an/an/an/a7.425



Novartis AG

US Patent


Assay Description
Recombinant human factor B (expressed in drosophila cells and purified using standard methods) labeled with biotin (10 nM), europium-labeled streptav...


US Patent US9475806 (2016)


BindingDB Entry DOI: 10.7270/Q2KS6QG2
More data for this
Ligand-Target Pair
Complement factor B


(Homo sapiens (Human))
BDBM251884
PNG
(US9475806, 14-I b) (+))
Show SMILES CCc1cc(C)c2[nH]ccc2c1C(O)(c1nc2cc(cnc2[nH]1)C#N)C(F)(F)F
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 2.35E+3n/an/an/an/a7.425



Novartis AG

US Patent


Assay Description
Recombinant human factor B (expressed in drosophila cells and purified using standard methods) labeled with biotin (10 nM), europium-labeled streptav...


US Patent US9475806 (2016)


BindingDB Entry DOI: 10.7270/Q2KS6QG2
More data for this
Ligand-Target Pair
Complement factor B


(Homo sapiens (Human))
BDBM251881
PNG
(US9475806, 11-B b) (+))
Show SMILES CNC(C)(c1nc2cc(cnc2[nH]1)C#N)c1c(OC)cc(C)c2[nH]ccc12
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 3.14E+3n/an/an/an/a7.425



Novartis AG

US Patent


Assay Description
Recombinant human factor B (expressed in drosophila cells and purified using standard methods) labeled with biotin (10 nM), europium-labeled streptav...


US Patent US9475806 (2016)


BindingDB Entry DOI: 10.7270/Q2KS6QG2
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%