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USPatent US9682968

Compile data set for download or QSAR
Found 110 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Complement factor B


(Homo sapiens (Human))
BDBM159545
PNG
(US10093663, Example 17-30 | US9682968, Example-17-...)
Show SMILES CCC1CCN(Cc2c(OC)cc(C)c3[nH]ccc23)C(C1)c1ccc(cc1)C(O)=O
PDB

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US Patent
n/an/a 0.0100n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


US Patent US9682968 (2017)


BindingDB Entry DOI: 10.7270/Q2XG9P9J
More data for this
Ligand-Target Pair
Complement factor B


(Homo sapiens (Human))
BDBM159938
PNG
(US10093663, Example 17-29 | US9682968, Example-17-...)
Show SMILES COc1cc(C)c2[nH]ccc2c1CN1CCC2(CC2)CC1c1ccc(cc1)C(O)=O
PDB

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Novartis AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


US Patent US9682968 (2017)


BindingDB Entry DOI: 10.7270/Q2XG9P9J
More data for this
Ligand-Target Pair
Complement factor B


(Homo sapiens (Human))
BDBM160272
PNG
(US9682968, Example-22-2b (-))
Show SMILES COc1cc(C)c2[nH]ccc2c1CN1CCC(C)(C)CC1c1ccc(cc1)C(O)=O
PDB

UniProtKB/SwissProt

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Novartis AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


US Patent US9682968 (2017)


BindingDB Entry DOI: 10.7270/Q2XG9P9J
More data for this
Ligand-Target Pair
Complement factor B


(Homo sapiens (Human))
BDBM160475
PNG
(US10093663, Example 26b | US9682968, Example-26a)
Show SMILES CCO[C@H]1CCN(Cc2c(OC)cc(C)c3[nH]ccc23)[C@@H](C1)c1ccc(cc1)C(O)=O |r|
PDB

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n/an/a 0.0100n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


US Patent US9682968 (2017)


BindingDB Entry DOI: 10.7270/Q2XG9P9J
More data for this
Ligand-Target Pair
Complement factor B


(Homo sapiens (Human))
BDBM160483
PNG
(US9682968, Example-27-3a (-))
Show SMILES COC1CCN(Cc2c(cc(C)c3[nH]ccc23)C2CC2)C(C1)c1ccc(cc1)C(O)=O
PDB

UniProtKB/SwissProt

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Novartis AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


US Patent US9682968 (2017)


BindingDB Entry DOI: 10.7270/Q2XG9P9J
More data for this
Ligand-Target Pair
Complement factor B


(Homo sapiens (Human))
BDBM159970
PNG
(US10093663, Example 20a | US9682968, Example-20a)
Show SMILES COc1cc(C)c2[nH]ccc2c1CN1CC[C@@H](C)C[C@H]1c1ccc(cc1)C(O)=O |r|
PDB

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Novartis AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


US Patent US9682968 (2017)


BindingDB Entry DOI: 10.7270/Q2XG9P9J
More data for this
Ligand-Target Pair
Complement factor B


(Homo sapiens (Human))
BDBM160485
PNG
(US9682968, Example-27-4a (+))
Show SMILES CCOC1CCN(Cc2c(cc(C)c3[nH]ccc23)C2CC2)C(C1)c1ccc(cc1)C(O)=O
PDB

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Novartis AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


US Patent US9682968 (2017)


BindingDB Entry DOI: 10.7270/Q2XG9P9J
More data for this
Ligand-Target Pair
Complement factor B


(Homo sapiens (Human))
BDBM160480
PNG
(US9682968, Example-27-1b (-))
Show SMILES COC1CCN(Cc2c(C)cc(C)c3[nH]ccc23)C(C1)c1ccc(cc1)C(O)=O
PDB

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Novartis AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


US Patent US9682968 (2017)


BindingDB Entry DOI: 10.7270/Q2XG9P9J
More data for this
Ligand-Target Pair
Complement factor B


(Homo sapiens (Human))
BDBM159486
PNG
(US10093663, Example 17-11 | US9682968, Example-17-...)
Show SMILES CCCO[C@H]1CCN(Cc2c(OC)cc(C)c3[nH]ccc23)[C@@H](C1)c1ccc(cc1)C(O)=O |r|
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Novartis AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


US Patent US9682968 (2017)


BindingDB Entry DOI: 10.7270/Q2XG9P9J
More data for this
Ligand-Target Pair
Complement factor B


(Homo sapiens (Human))
BDBM160102
PNG
(US9682968, Example-22-1a (-))
Show SMILES CCOC1CCN(Cc2c(OC)cc(C)c3[nH]ccc23)C(C1)c1ccc(nc1)C(O)=O
PDB

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Novartis AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


US Patent US9682968 (2017)


BindingDB Entry DOI: 10.7270/Q2XG9P9J
More data for this
Ligand-Target Pair
Complement factor B


(Homo sapiens (Human))
BDBM160036
PNG
(US10093663, Example 21a | US9682968, Example-21a)
Show SMILES CO[C@H]1CCN(Cc2c(OC)cc(C)c3[nH]ccc23)[C@@H](C1)c1ccc(cc1)C(O)=O |r|
PDB

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Novartis AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


US Patent US9682968 (2017)


BindingDB Entry DOI: 10.7270/Q2XG9P9J
More data for this
Ligand-Target Pair
Complement factor B


(Homo sapiens (Human))
BDBM159312
PNG
(US10093663, Example 17-1 | US9682968, Example-17-1)
Show SMILES Cc1cc(C2CC2)c(CN2CCCC[C@H]2c2ccc(cc2)C(O)=O)c2cc[nH]c12 |r|
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Novartis AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


US Patent US9682968 (2017)


BindingDB Entry DOI: 10.7270/Q2XG9P9J
More data for this
Ligand-Target Pair
Complement factor B


(Homo sapiens (Human))
BDBM159545
PNG
(US10093663, Example 17-30 | US9682968, Example-17-...)
Show SMILES CCC1CCN(Cc2c(OC)cc(C)c3[nH]ccc23)C(C1)c1ccc(cc1)C(O)=O
PDB

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Novartis AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


US Patent US9682968 (2017)


BindingDB Entry DOI: 10.7270/Q2XG9P9J
More data for this
Ligand-Target Pair
Complement factor B


(Homo sapiens (Human))
BDBM160499
PNG
(US10093663, Example 36 | US9682968, Example-36)
Show SMILES CCOC1CCN(Cc2c(OC)cc(C)c3[nH]ccc23)C(C1)c1ccc(cc1)-c1nn[nH]n1
PDB

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Novartis AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


US Patent US9682968 (2017)


BindingDB Entry DOI: 10.7270/Q2XG9P9J
More data for this
Ligand-Target Pair
Complement factor B


(Homo sapiens (Human))
BDBM160481
PNG
(US9682968, Example-27-2a (+))
Show SMILES CCOC1CCN(Cc2c(C)cc(C)c3[nH]ccc23)C(C1)c1ccc(cc1)C(O)=O
PDB

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Novartis AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


US Patent US9682968 (2017)


BindingDB Entry DOI: 10.7270/Q2XG9P9J
More data for this
Ligand-Target Pair
Complement factor B


(Homo sapiens (Human))
BDBM160500
PNG
(US10093663, Example 37 | US9682968, Example-37)
Show SMILES CCO[C@H]1CCN(Cc2c(OC)cc(C)c3[nH]ccc23)[C@@H](C1)c1ccc(cc1)C(=O)NS(C)(=O)=O |r|
PDB

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Novartis AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


US Patent US9682968 (2017)


BindingDB Entry DOI: 10.7270/Q2XG9P9J
More data for this
Ligand-Target Pair
Complement factor B


(Homo sapiens (Human))
BDBM159319
PNG
(US9682968, Example-17-5)
Show SMILES COc1cc(C)c2[nH]ccc2c1CN1CCCC[C@H]1c1ccc(cc1)C(O)=O |r|
PDB

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Novartis AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


US Patent US9682968 (2017)


BindingDB Entry DOI: 10.7270/Q2XG9P9J
More data for this
Ligand-Target Pair
Complement factor B


(Homo sapiens (Human))
BDBM159566
PNG
(US10093663, Example 17-18 | US9682968, Example-17-...)
Show SMILES COC1CCN(Cc2c(cc(C)c3[nH]ccc23)C2CC2)C(C1)c1ccc(nc1)C(O)=O
PDB

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Novartis AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


US Patent US9682968 (2017)


BindingDB Entry DOI: 10.7270/Q2XG9P9J
More data for this
Ligand-Target Pair
Complement factor B


(Homo sapiens (Human))
BDBM159311
PNG
(US10093663, Example 16 | US9682968, Example-16)
Show SMILES Cc1cc(C2CC2)c(CN2CCCC[C@H]2c2ccc(C(O)=O)c(F)c2)c2cc[nH]c12 |r|
PDB

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Novartis AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


US Patent US9682968 (2017)


BindingDB Entry DOI: 10.7270/Q2XG9P9J
More data for this
Ligand-Target Pair
Complement factor B


(Homo sapiens (Human))
BDBM159314
PNG
(US9682968, Example-17-3)
Show SMILES Cc1cc(C2CC2)c(CN2CCCC[C@H]2c2ccc(nc2)C(O)=O)c2cc[nH]c12 |r|
PDB

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Novartis AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


US Patent US9682968 (2017)


BindingDB Entry DOI: 10.7270/Q2XG9P9J
More data for this
Ligand-Target Pair
Complement factor B


(Homo sapiens (Human))
BDBM159873
PNG
(US10093663, Example 17-24 | US9682968, Example-17-...)
Show SMILES COc1cc(C)c2[nH]ccc2c1CN1CCCC[C@H]1c1ccc(cc1)-c1cc[nH]n1 |r|
PDB

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Novartis AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


US Patent US9682968 (2017)


BindingDB Entry DOI: 10.7270/Q2XG9P9J
More data for this
Ligand-Target Pair
Complement factor B


(Homo sapiens (Human))
BDBM159289
PNG
(US10093663, Example 5-12 | US9682968, Example-5-12)
Show SMILES Cc1cc(C)c2[nH]ccc2c1CN1CCCCC1c1ccc(cc1)-c1nn[nH]n1
PDB

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Novartis AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


US Patent US9682968 (2017)


BindingDB Entry DOI: 10.7270/Q2XG9P9J
More data for this
Ligand-Target Pair
Complement factor B


(Homo sapiens (Human))
BDBM160474
PNG
(US9682968, Example-25b (-))
Show SMILES Cc1cc(C)c2[nH]ccc2c1CN1CCCCC1c1ccc(cc1)C(O)=O
PDB

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Novartis AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


US Patent US9682968 (2017)


BindingDB Entry DOI: 10.7270/Q2XG9P9J
More data for this
Ligand-Target Pair
Complement factor B


(Homo sapiens (Human))
BDBM159920
PNG
(US10093663, Example 17-25 | US9682968, Example-17-...)
Show SMILES COc1cc(C)c2[nH]ccc2c1CN1CCCCC1c1ccc(C(O)=O)c2ccccc12
PDB

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Novartis AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


US Patent US9682968 (2017)


BindingDB Entry DOI: 10.7270/Q2XG9P9J
More data for this
Ligand-Target Pair
Complement factor B


(Homo sapiens (Human))
BDBM159509
PNG
(US10093663, Example 17-13 | US9682968, Example-17-...)
Show SMILES COc1cc(C)c2[nH]ccc2c1CN1CCCCC1c1ccc(cc1C)C(O)=O
PDB

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Novartis AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


US Patent US9682968 (2017)


BindingDB Entry DOI: 10.7270/Q2XG9P9J
More data for this
Ligand-Target Pair
Complement factor B


(Homo sapiens (Human))
BDBM160506
PNG
(US10093663, Example 40 | US9682968, Example-40)
Show SMILES CC(=O)NS(=O)(=O)c1ccc(cc1)C1CCCCN1Cc1c(cc(C)c2[nH]ccc12)C1CC1
PDB

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Novartis AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


US Patent US9682968 (2017)


BindingDB Entry DOI: 10.7270/Q2XG9P9J
More data for this
Ligand-Target Pair
Complement factor B


(Homo sapiens (Human))
BDBM159379
PNG
(US10093663, Example 17-8 | US9682968, Example-17-8)
Show SMILES COc1cc(C)c2[nH]ccc2c1CN1CCCC[C@H]1c1ccc(cc1F)C(O)=O |r|
PDB

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Novartis AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


US Patent US9682968 (2017)


BindingDB Entry DOI: 10.7270/Q2XG9P9J
More data for this
Ligand-Target Pair
Complement factor B


(Homo sapiens (Human))
BDBM159316
PNG
(US9682968, Example-17-4)
Show SMILES COc1cc(ccc1[C@@H]1CCCCN1Cc1c(cc(C)c2[nH]ccc12)C1CC1)C(O)=O |r|
PDB

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Novartis AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


US Patent US9682968 (2017)


BindingDB Entry DOI: 10.7270/Q2XG9P9J
More data for this
Ligand-Target Pair
Complement factor B


(Homo sapiens (Human))
BDBM159382
PNG
(US10093663, Example 17-10 | US9682968, Example-17-...)
Show SMILES COc1cc(C)c2[nH]ccc2c1CN1CCCC[C@H]1c1ccc(cn1)C(O)=O |r|
PDB

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Novartis AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


US Patent US9682968 (2017)


BindingDB Entry DOI: 10.7270/Q2XG9P9J
More data for this
Ligand-Target Pair
Complement factor B


(Homo sapiens (Human))
BDBM159841
PNG
(US10093663, Example 17-22 | US9682968, Example-17-...)
Show SMILES COc1cc(C)c2[nH]ccc2c1CN1CCCCCC1c1ccc(cc1)C(O)=O
PDB

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Novartis AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


US Patent US9682968 (2017)


BindingDB Entry DOI: 10.7270/Q2XG9P9J
More data for this
Ligand-Target Pair
Complement factor B


(Homo sapiens (Human))
BDBM159313
PNG
(US9682968, Example-17-2)
Show SMILES Cc1cc(C2CC2)c(CN2CCCC2c2ccc(cc2)C(O)=O)c2cc[nH]c12
PDB

UniProtKB/SwissProt

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US Patent
n/an/a 0.120n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


US Patent US9682968 (2017)


BindingDB Entry DOI: 10.7270/Q2XG9P9J
More data for this
Ligand-Target Pair
Complement factor B


(Homo sapiens (Human))
BDBM160501
PNG
(US10093663, Example 38 | US9682968, Example-38)
Show SMILES CNC(=O)c1ccc(cc1)[C@@H]1C[C@H](CCN1Cc1c(OC)cc(C)c2[nH]ccc12)OC |r|
PDB

UniProtKB/SwissProt

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US Patent
n/an/a 0.130n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


US Patent US9682968 (2017)


BindingDB Entry DOI: 10.7270/Q2XG9P9J
More data for this
Ligand-Target Pair
Complement factor B


(Homo sapiens (Human))
BDBM159303
PNG
(US10093663, Example 13 | US9682968, Example-13)
Show SMILES Cc1cc(Cl)c(CN2CCCCC2c2ccc(cc2)C(O)=O)c2cc[nH]c12
PDB

UniProtKB/SwissProt

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n/an/a 0.140n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


US Patent US9682968 (2017)


BindingDB Entry DOI: 10.7270/Q2XG9P9J
More data for this
Ligand-Target Pair
Complement factor B


(Homo sapiens (Human))
BDBM159932
PNG
(US10093663, Example 17-28 | US9682968, Example-17-...)
Show SMILES COc1cc(C)c2[nH]ccc2c1CN1CCCCC1c1ccc(C(O)=O)c(OC)c1
PDB

UniProtKB/SwissProt

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US Patent
n/an/a 0.160n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


US Patent US9682968 (2017)


BindingDB Entry DOI: 10.7270/Q2XG9P9J
More data for this
Ligand-Target Pair
Complement factor B


(Homo sapiens (Human))
BDBM160507
PNG
(US9682968, Example-41)
Show SMILES CCNC(=O)c1ccc(cc1)[C@@H]1C[C@H](C)CCN1Cc1c(OC)cc(C)c2[nH]ccc12 |r|
PDB

UniProtKB/SwissProt

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US Patent
n/an/a 0.170n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


US Patent US9682968 (2017)


BindingDB Entry DOI: 10.7270/Q2XG9P9J
More data for this
Ligand-Target Pair
Complement factor B


(Homo sapiens (Human))
BDBM159157
PNG
(US10093663, Example 5-4 | US9682968, Example-5-4)
Show SMILES Cc1cc(C)c2[nH]ccc2c1CN1CCCCC1c1ccc(cc1)S(N)(=O)=O
PDB

UniProtKB/SwissProt

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US Patent
n/an/a 0.180n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


US Patent US9682968 (2017)


BindingDB Entry DOI: 10.7270/Q2XG9P9J
More data for this
Ligand-Target Pair
Complement factor B


(Homo sapiens (Human))
BDBM159301
PNG
(US9682968, Example-11)
Show SMILES Cc1cc(C)c2[nH]ccc2c1CN1CCC(O)CC1c1ccc(cc1)C(N)=O
PDB

UniProtKB/SwissProt

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US Patent
n/an/a 0.230n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


US Patent US9682968 (2017)


BindingDB Entry DOI: 10.7270/Q2XG9P9J
More data for this
Ligand-Target Pair
Complement factor B


(Homo sapiens (Human))
BDBM160508
PNG
(US10093663, Example 42 | US9682968, Example-42)
Show SMILES CCO[C@H]1CCN(Cc2c(OC)cc(C)c3[nH]ccc23)[C@@H](C1)c1ccc(cc1)C(=O)OCC |r|
PDB

UniProtKB/SwissProt

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US Patent
n/an/a 0.240n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


US Patent US9682968 (2017)


BindingDB Entry DOI: 10.7270/Q2XG9P9J
More data for this
Ligand-Target Pair
Complement factor B


(Homo sapiens (Human))
BDBM160504
PNG
(US10093663, Example 39-3 | US9682968, Example-39-3)
Show SMILES CO[C@H]1CCN(Cc2c(OC)cc(C)c3[nH]ccc23)[C@@H](C1)c1ccc(cc1)C(=O)NCCO |r|
PDB

UniProtKB/SwissProt

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US Patent
n/an/a 0.280n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


US Patent US9682968 (2017)


BindingDB Entry DOI: 10.7270/Q2XG9P9J
More data for this
Ligand-Target Pair
Complement factor B


(Homo sapiens (Human))
BDBM159976
PNG
(US10093663, Example 20b | US9682968, Example-20b)
Show SMILES COc1cc(C)c2[nH]ccc2c1CN1CC[C@H](C)C[C@@H]1c1ccc(cc1)C(O)=O |r|
PDB

UniProtKB/SwissProt

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US Patent
n/an/a 0.290n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


US Patent US9682968 (2017)


BindingDB Entry DOI: 10.7270/Q2XG9P9J
More data for this
Ligand-Target Pair
Complement factor B


(Homo sapiens (Human))
BDBM160505
PNG
(US10093663, Example 39-4 | US9682968, Example-39-4)
Show SMILES COCCNC(=O)c1ccc(cc1)[C@@H]1C[C@H](CCN1Cc1c(OC)cc(C)c2[nH]ccc12)OC |r|
PDB

UniProtKB/SwissProt

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US Patent
n/an/a 0.300n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


US Patent US9682968 (2017)


BindingDB Entry DOI: 10.7270/Q2XG9P9J
More data for this
Ligand-Target Pair
Complement factor B


(Homo sapiens (Human))
BDBM160495
PNG
(US10093663, Example 32-3 | US9682968, Example-32-3)
Show SMILES COC1CCN(Cc2c(OC)cc(C)c3[nH]ccc23)C(C1)c1ccc(CO)cc1
PDB

UniProtKB/SwissProt

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US Patent
n/an/a 0.340n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


US Patent US9682968 (2017)


BindingDB Entry DOI: 10.7270/Q2XG9P9J
More data for this
Ligand-Target Pair
Complement factor B


(Homo sapiens (Human))
BDBM159506
PNG
(US10093663, Example 17-12 | US9682968, Example-17-...)
Show SMILES COc1cc(C)c2[nH]ccc2c1CN1CC[C@H](O)C[C@H]1c1ccc(cc1)C(O)=O |r|
PDB

UniProtKB/SwissProt

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n/an/a 0.450n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


US Patent US9682968 (2017)


BindingDB Entry DOI: 10.7270/Q2XG9P9J
More data for this
Ligand-Target Pair
Complement factor B


(Homo sapiens (Human))
BDBM159296
PNG
(US10093663, Example 9-2 | US9682968, Example-9-2)
Show SMILES COC1CCN(Cc2c(C)cc(C)c3[nH]ccc23)C(C1)c1ccc(cc1)C(N)=O
PDB

UniProtKB/SwissProt

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n/an/a 0.640n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


US Patent US9682968 (2017)


BindingDB Entry DOI: 10.7270/Q2XG9P9J
More data for this
Ligand-Target Pair
Complement factor B


(Homo sapiens (Human))
BDBM160051
PNG
(US10093663, Example 21b | US9682968, Example-21b)
Show SMILES CO[C@@H]1CCN(Cc2c(OC)cc(C)c3[nH]ccc23)[C@H](C1)c1ccc(cc1)C(O)=O |r|
PDB

UniProtKB/SwissProt

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US Patent
n/an/a 0.650n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


US Patent US9682968 (2017)


BindingDB Entry DOI: 10.7270/Q2XG9P9J
More data for this
Ligand-Target Pair
Complement factor B


(Homo sapiens (Human))
BDBM159184
PNG
(US10093663, Example 5-6 | US9682968, Example-5-6)
Show SMILES CNS(=O)(=O)c1ccc(cc1)C1CCCCN1Cc1c(C)cc(C)c2[nH]ccc12
PDB

UniProtKB/SwissProt

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US Patent
n/an/a 0.660n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


US Patent US9682968 (2017)


BindingDB Entry DOI: 10.7270/Q2XG9P9J
More data for this
Ligand-Target Pair
Complement factor B


(Homo sapiens (Human))
BDBM159294
PNG
(US10093663, Example 8 | US9682968, Example-8)
Show SMILES Cc1cc(C)c2[nH]ccc2c1CN1CCCCC1c1ccc(cc1)C(N)=O
PDB

UniProtKB/SwissProt

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US Patent
n/an/a 0.710n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


US Patent US9682968 (2017)


BindingDB Entry DOI: 10.7270/Q2XG9P9J
More data for this
Ligand-Target Pair
Complement factor B


(Homo sapiens (Human))
BDBM159114
PNG
(US9682968, Example-4b (-))
Show SMILES COC1CCN(Cc2c(C)cc(C)c3[nH]ccc23)C(C1)c1ccccc1
PDB

UniProtKB/SwissProt

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US Patent
n/an/a 0.720n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


US Patent US9682968 (2017)


BindingDB Entry DOI: 10.7270/Q2XG9P9J
More data for this
Ligand-Target Pair
Complement factor B


(Homo sapiens (Human))
BDBM160484
PNG
(US9682968, Example-27-3b (+))
Show SMILES COC1CCN(Cc2c(cc(C)c3[nH]ccc23)C2CC2)C(C1)c1ccc(cc1)C(O)=O
PDB

UniProtKB/SwissProt

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US Patent
n/an/a 0.740n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


US Patent US9682968 (2017)


BindingDB Entry DOI: 10.7270/Q2XG9P9J
More data for this
Ligand-Target Pair
Complement factor B


(Homo sapiens (Human))
BDBM159840
PNG
(US10093663, Example 17-21 | US9682968, Example-17-...)
Show SMILES Cc1cc(C)c2[nH]ccc2c1CN1CCCCC1c1cccc(c1)C(O)=O
PDB

UniProtKB/SwissProt

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n/an/a 0.840n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


US Patent US9682968 (2017)


BindingDB Entry DOI: 10.7270/Q2XG9P9J
More data for this
Ligand-Target Pair
Complement factor B


(Homo sapiens (Human))
BDBM160476
PNG
(US9682968, Example-26b)
Show SMILES CCO[C@@H]1CCN(Cc2c(OC)cc(C)c3[nH]ccc23)[C@H](C1)c1ccc(cc1)C(O)=O |r|
PDB

UniProtKB/SwissProt

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US Patent
n/an/a 1.10n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


US Patent US9682968 (2017)


BindingDB Entry DOI: 10.7270/Q2XG9P9J
More data for this
Ligand-Target Pair
Complement factor B


(Homo sapiens (Human))
BDBM160496
PNG
(US10093663, Example 33 | US9682968, Example-33)
Show SMILES Cc1cc(C)c2[nH]ccc2c1CN1CCCCC1c1cccc(c1)-c1nn[nH]n1
PDB

UniProtKB/SwissProt

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US Patent
n/an/a 1.20n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


US Patent US9682968 (2017)


BindingDB Entry DOI: 10.7270/Q2XG9P9J
More data for this
Ligand-Target Pair
Complement factor B


(Homo sapiens (Human))
BDBM160490
PNG
(US10093663, Example 30-3 | US9682968, Example-30-2...)
Show SMILES COc1cc(C)c2[nH]ccc2c1CN1CC(O)CCC1c1ccc(cc1)C(O)=O
PDB

UniProtKB/SwissProt

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US Patent
n/an/a 1.30n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


US Patent US9682968 (2017)


BindingDB Entry DOI: 10.7270/Q2XG9P9J
More data for this
Ligand-Target Pair
Complement factor B


(Homo sapiens (Human))
BDBM160490
PNG
(US10093663, Example 30-3 | US9682968, Example-30-2...)
Show SMILES COc1cc(C)c2[nH]ccc2c1CN1CC(O)CCC1c1ccc(cc1)C(O)=O
PDB

UniProtKB/SwissProt

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US Patent
n/an/a 1.30n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


US Patent US9682968 (2017)


BindingDB Entry DOI: 10.7270/Q2XG9P9J
More data for this
Ligand-Target Pair
Complement factor B


(Homo sapiens (Human))
BDBM159288
PNG
(US10093663, Example 5-11 | US9682968, Example-5-11)
Show SMILES Cc1cc(C)c2[nH]ccc2c1CN1CCCCC1c1ccc(cc1)S(C)(=O)=O
PDB

UniProtKB/SwissProt

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n/an/a 1.30n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


US Patent US9682968 (2017)


BindingDB Entry DOI: 10.7270/Q2XG9P9J
More data for this
Ligand-Target Pair
Complement factor B


(Homo sapiens (Human))
BDBM160487
PNG
(US10093663, Example 30-1 | US9682968, Example-28 |...)
Show SMILES COC1CCC(N(Cc2c(OC)cc(C)c3[nH]ccc23)C1)c1ccc(cc1)C(O)=O
PDB

UniProtKB/SwissProt

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n/an/a 1.5n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


US Patent US9682968 (2017)


BindingDB Entry DOI: 10.7270/Q2XG9P9J
More data for this
Ligand-Target Pair
Complement factor B


(Homo sapiens (Human))
BDBM159287
PNG
(US10093663, Example 5-10 | US9682968, Example-5-10)
Show SMILES Cc1cc(C)c2[nH]ccc2c1CN1CCCCC1c1ccc(CO)cc1
PDB

UniProtKB/SwissProt

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n/an/a 1.5n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


US Patent US9682968 (2017)


BindingDB Entry DOI: 10.7270/Q2XG9P9J
More data for this
Ligand-Target Pair
Complement factor B


(Homo sapiens (Human))
BDBM160502
PNG
(US10093663, Example 39-1 | US9682968, Example-39-1)
Show SMILES CO[C@H]1CCN(Cc2c(OC)cc(C)c3[nH]ccc23)[C@@H](C1)c1ccc(cc1)C(=O)N(C)C |r|
PDB

UniProtKB/SwissProt

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n/an/a 1.70n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


US Patent US9682968 (2017)


BindingDB Entry DOI: 10.7270/Q2XG9P9J
More data for this
Ligand-Target Pair
Complement factor B


(Homo sapiens (Human))
BDBM159309
PNG
(US10093663, Example 15 | US9682968, Example-14 | U...)
Show SMILES COC1CCN(Cc2c(C)cc(C)c3[nH]ccc23)C(C1)c1ccc(cc1)C(=O)OC
PDB

UniProtKB/SwissProt

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n/an/a 1.70n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


US Patent US9682968 (2017)


BindingDB Entry DOI: 10.7270/Q2XG9P9J
More data for this
Ligand-Target Pair
Complement factor B


(Homo sapiens (Human))
BDBM160486
PNG
(US9682968, Example-27-4b (-))
Show SMILES CCOC1CCN(Cc2c(cc(C)c3[nH]ccc23)C2CC2)C(C1)c1ccc(cc1)C(O)=O
PDB

UniProtKB/SwissProt

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n/an/a 1.70n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


US Patent US9682968 (2017)


BindingDB Entry DOI: 10.7270/Q2XG9P9J
More data for this
Ligand-Target Pair
Complement factor B


(Homo sapiens (Human))
BDBM159844
PNG
(US10093663, Example 17-23 | US9682968, Example-17-...)
Show SMILES COc1cc(C)c2[nH]ccc2c1CN1CCCC[C@H]1c1ccc(cc1)-c1cn[nH]c1 |r|
PDB

UniProtKB/SwissProt

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n/an/a 1.70n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


US Patent US9682968 (2017)


BindingDB Entry DOI: 10.7270/Q2XG9P9J
More data for this
Ligand-Target Pair
Complement factor B


(Homo sapiens (Human))
BDBM160317
PNG
(US9682968, Example-23b (-))
Show SMILES CCOC1CCN(Cc2c(OC)cc(C)c3[nH]ccc23)C(C1)c1ccc(cc1)C#N
PDB

UniProtKB/SwissProt

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n/an/a 1.80n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


US Patent US9682968 (2017)


BindingDB Entry DOI: 10.7270/Q2XG9P9J
More data for this
Ligand-Target Pair
Complement factor B


(Homo sapiens (Human))
BDBM159510
PNG
(US9682968, Example-17-14)
Show SMILES COc1cc(C)c2[nH]ccc2c1CN1CC(C)CCC1c1ccc(cc1)C(O)=O
PDB

UniProtKB/SwissProt

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n/an/a 1.80n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


US Patent US9682968 (2017)


BindingDB Entry DOI: 10.7270/Q2XG9P9J
More data for this
Ligand-Target Pair
Complement factor B


(Homo sapiens (Human))
BDBM160503
PNG
(US10093663, Example 39-2 | US9682968, Example-39-2)
Show SMILES CO[C@H]1CCN(Cc2c(OC)cc(C)c3[nH]ccc23)[C@@H](C1)c1ccc(cc1)C(=O)N1CCOCC1 |r|
PDB

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n/an/a 1.80n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


US Patent US9682968 (2017)


BindingDB Entry DOI: 10.7270/Q2XG9P9J
More data for this
Ligand-Target Pair
Complement factor B


(Homo sapiens (Human))
BDBM160136
PNG
(US9682968, Example-22-1a (+))
Show SMILES CCOC1CCN(Cc2c(OC)cc(C)c3[nH]ccc23)C(C1)c1ccc(nc1)C(O)=O
PDB

UniProtKB/SwissProt

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n/an/a 1.80n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


US Patent US9682968 (2017)


BindingDB Entry DOI: 10.7270/Q2XG9P9J
More data for this
Ligand-Target Pair
Complement factor B


(Homo sapiens (Human))
BDBM159546
PNG
(US10093663, Example 17-16 | US9682968, Example-17-...)
Show SMILES COc1cc(C)c2[nH]ccc2c1CN1CCCCC1c1ccc(CC(O)=O)cc1
PDB

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n/an/a 1.90n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


US Patent US9682968 (2017)


BindingDB Entry DOI: 10.7270/Q2XG9P9J
More data for this
Ligand-Target Pair
Complement factor B


(Homo sapiens (Human))
BDBM159295
PNG
(US10093663, Example 9-1 | US9682968, Example-9-1)
Show SMILES Cc1cc(Cl)c(CN2CCCCC2c2ccc(cc2)C(N)=O)c2cc[nH]c12
PDB

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Novartis AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


US Patent US9682968 (2017)


BindingDB Entry DOI: 10.7270/Q2XG9P9J
More data for this
Ligand-Target Pair
Complement factor B


(Homo sapiens (Human))
BDBM159565
PNG
(US10093663, Example 17-17 | US9682968, Example-17-...)
Show SMILES COc1cc(C)c2[nH]ccc2c1CN1CCCCC1c1cccc(CC(O)=O)c1
PDB

UniProtKB/SwissProt

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n/an/a 2.10n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


US Patent US9682968 (2017)


BindingDB Entry DOI: 10.7270/Q2XG9P9J
More data for this
Ligand-Target Pair
Complement factor B


(Homo sapiens (Human))
BDBM160140
PNG
(US9682968, Example-22-2a (+))
Show SMILES COc1cc(C)c2[nH]ccc2c1CN1CCC(C)(C)CC1c1ccc(cc1)C(O)=O
PDB

UniProtKB/SwissProt

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n/an/a 2.20n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


US Patent US9682968 (2017)


BindingDB Entry DOI: 10.7270/Q2XG9P9J
More data for this
Ligand-Target Pair
Complement factor B


(Homo sapiens (Human))
BDBM159302
PNG
(US10093663, Example 12 | US9682968, Example-12)
Show SMILES Cc1cc(C)c2[nH]ccc2c1CN1CCC(O)CC1c1ccc(cc1)C(O)=O
PDB

UniProtKB/SwissProt

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n/an/a 2.30n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


US Patent US9682968 (2017)


BindingDB Entry DOI: 10.7270/Q2XG9P9J
More data for this
Ligand-Target Pair
Complement factor B


(Homo sapiens (Human))
BDBM159149
PNG
(US10093663, Example 5-3 | US9682968, Example-5-2 |...)
Show SMILES Cc1cc(C)c2[nH]ccc2c1CN1CCC(CO)CC1c1ccccc1
PDB

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n/an/a 2.60n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


US Patent US9682968 (2017)


BindingDB Entry DOI: 10.7270/Q2XG9P9J
More data for this
Ligand-Target Pair
Complement factor B


(Homo sapiens (Human))
BDBM160498
PNG
(US10093663, Example 35 | US9682968, Example-35)
Show SMILES Cc1cc(C)c2[nH]ccc2c1CN1CCCCC1c1cccc(CO)c1
PDB

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n/an/a 2.70n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


US Patent US9682968 (2017)


BindingDB Entry DOI: 10.7270/Q2XG9P9J
More data for this
Ligand-Target Pair
Complement factor B


(Homo sapiens (Human))
BDBM159950
PNG
(US10093663, Example 19 | US9682968, Example-18 | U...)
Show SMILES Cc1cc(C)c2[nH]ccc2c1CN1CCC(CC#N)CC1c1ccccc1
PDB

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n/an/a 2.80n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


US Patent US9682968 (2017)


BindingDB Entry DOI: 10.7270/Q2XG9P9J
More data for this
Ligand-Target Pair
Complement factor B


(Homo sapiens (Human))
BDBM159593
PNG
(US10093663, Example 17-20 | US9682968, Example-17-...)
Show SMILES COc1cc(C)c2[nH]ccc2c1CN1CCCCC1c1nc(C)c(s1)C(O)=O
PDB

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n/an/a 2.80n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


US Patent US9682968 (2017)


BindingDB Entry DOI: 10.7270/Q2XG9P9J
More data for this
Ligand-Target Pair
Complement factor B


(Homo sapiens (Human))
BDBM160497
PNG
(US10093663, Example 34 | US9682968, Example-34)
Show SMILES Cc1cc(C)c2[nH]ccc2c1CN1CCCCC1c1cccc(c1)C(N)=O
PDB

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n/an/a 2.90n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


US Patent US9682968 (2017)


BindingDB Entry DOI: 10.7270/Q2XG9P9J
More data for this
Ligand-Target Pair
Complement factor B


(Homo sapiens (Human))
BDBM160487
PNG
(US10093663, Example 30-1 | US9682968, Example-28 |...)
Show SMILES COC1CCC(N(Cc2c(OC)cc(C)c3[nH]ccc23)C1)c1ccc(cc1)C(O)=O
PDB

UniProtKB/SwissProt

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n/an/a 3.40n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


US Patent US9682968 (2017)


BindingDB Entry DOI: 10.7270/Q2XG9P9J
More data for this
Ligand-Target Pair
Complement factor B


(Homo sapiens (Human))
BDBM160487
PNG
(US10093663, Example 30-1 | US9682968, Example-28 |...)
Show SMILES COC1CCC(N(Cc2c(OC)cc(C)c3[nH]ccc23)C1)c1ccc(cc1)C(O)=O
PDB

UniProtKB/SwissProt

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n/an/a 3.40n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


US Patent US9682968 (2017)


BindingDB Entry DOI: 10.7270/Q2XG9P9J
More data for this
Ligand-Target Pair
Complement factor B


(Homo sapiens (Human))
BDBM159161
PNG
(US10093663, Example 5-5 | US9682968, Example-5-5)
Show SMILES Cc1cc(C)c2[nH]ccc2c1CN1CCCCC1c1cccc(c1)S(N)(=O)=O
PDB

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n/an/a 3.5n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


US Patent US9682968 (2017)


BindingDB Entry DOI: 10.7270/Q2XG9P9J
More data for this
Ligand-Target Pair
Complement factor B


(Homo sapiens (Human))
BDBM160479
PNG
(US9682968, Example-27-1a (+))
Show SMILES COC1CCN(Cc2c(C)cc(C)c3[nH]ccc23)C(C1)c1ccc(cc1)C(O)=O
PDB

UniProtKB/SwissProt

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n/an/a 3.70n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


US Patent US9682968 (2017)


BindingDB Entry DOI: 10.7270/Q2XG9P9J
More data for this
Ligand-Target Pair
Complement factor B


(Homo sapiens (Human))
BDBM159322
PNG
(US10093663, Example 17-7 | US9682968, Example-17-7)
Show SMILES COc1cc(C)c2[nH]ccc2c1CN1CCCCC1c1cccnc1
PDB

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n/an/a 4.5n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


US Patent US9682968 (2017)


BindingDB Entry DOI: 10.7270/Q2XG9P9J
More data for this
Ligand-Target Pair
Complement factor B


(Homo sapiens (Human))
BDBM159924
PNG
(US10093663, Example 17-27 | US9682968, Example-17-...)
Show SMILES COc1cc(C)c2[nH]ccc2c1C(N1CCCC[C@H]1c1ccc(cc1)C(O)=O)C(F)(F)F |r|
PDB

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n/an/a 4.60n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


US Patent US9682968 (2017)


BindingDB Entry DOI: 10.7270/Q2XG9P9J
More data for this
Ligand-Target Pair
Complement factor B


(Homo sapiens (Human))
BDBM159381
PNG
(US10093663, Example 17-9 | US9682968, Example-17-9)
Show SMILES COc1cc(C)c2[nH]ccc2c1CN1CCOC[C@H]1c1ccc(cc1)C(O)=O |r|
PDB

UniProtKB/SwissProt

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n/an/a 5n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


US Patent US9682968 (2017)


BindingDB Entry DOI: 10.7270/Q2XG9P9J
More data for this
Ligand-Target Pair
Complement factor B


(Homo sapiens (Human))
BDBM159102
PNG
(US10093663, Example 4b | US9682968, Example-3)
Show SMILES COC1CCN(Cc2c(C)cc(C)c3[nH]ccc23)C(C1)c1ccccc1
PDB

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n/an/a 6n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


US Patent US9682968 (2017)


BindingDB Entry DOI: 10.7270/Q2XG9P9J
More data for this
Ligand-Target Pair
Complement factor B


(Homo sapiens (Human))
BDBM159320
PNG
(US10093663, Example 17-6 | US9682968, Example-17-6)
Show SMILES COc1cc(C)c2[nH]ccc2c1CN1CCCCC1c1ccncc1
PDB

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n/an/a 6.60n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


US Patent US9682968 (2017)


BindingDB Entry DOI: 10.7270/Q2XG9P9J
More data for this
Ligand-Target Pair
Complement factor B


(Homo sapiens (Human))
BDBM160492
PNG
(BDBM160493 | US10093663, Example 32-1 | US9682968,...)
Show SMILES CNC1CCN(Cc2c(C)cc(C)c3[nH]ccc23)C(C1)c1ccccc1
PDB

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n/an/a 6.80n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


US Patent US9682968 (2017)


BindingDB Entry DOI: 10.7270/Q2XG9P9J
More data for this
Ligand-Target Pair
Complement factor B


(Homo sapiens (Human))
BDBM159270
PNG
(US10093663, Example 5-9 | US9682968, Example-5-9)
Show SMILES Cc1cc(C)c2[nH]ccc2c1CN1CCCCC1(CO)c1ccccc1
PDB

UniProtKB/SwissProt

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n/an/a 7.10n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


US Patent US9682968 (2017)


BindingDB Entry DOI: 10.7270/Q2XG9P9J
More data for this
Ligand-Target Pair
Complement factor B


(Homo sapiens (Human))
BDBM159137
PNG
(US10093663, Example 5-1 | US9682968, Example-5-1)
Show SMILES Cc1cc(C)c2[nH]ccc2c1CN1CCCCC1c1ccccc1
PDB

UniProtKB/SwissProt

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n/an/a 7.20n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


US Patent US9682968 (2017)


BindingDB Entry DOI: 10.7270/Q2XG9P9J
More data for this
Ligand-Target Pair
Complement factor B


(Homo sapiens (Human))
BDBM159149
PNG
(US10093663, Example 5-3 | US9682968, Example-5-2 |...)
Show SMILES Cc1cc(C)c2[nH]ccc2c1CN1CCC(CO)CC1c1ccccc1
PDB

UniProtKB/SwissProt

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n/an/a 7.90n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


US Patent US9682968 (2017)


BindingDB Entry DOI: 10.7270/Q2XG9P9J
More data for this
Ligand-Target Pair
Complement factor B


(Homo sapiens (Human))
BDBM159101
PNG
(US9682968, Example-2b (-))
Show SMILES Cc1cc(C)c2[nH]ccc2c1CN1CCC(O)CC1c1ccccc1
PDB

UniProtKB/SwissProt

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n/an/a 7.90n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


US Patent US9682968 (2017)


BindingDB Entry DOI: 10.7270/Q2XG9P9J
More data for this
Ligand-Target Pair
Complement factor B


(Homo sapiens (Human))
BDBM160490
PNG
(US10093663, Example 30-3 | US9682968, Example-30-2...)
Show SMILES COc1cc(C)c2[nH]ccc2c1CN1CC(O)CCC1c1ccc(cc1)C(O)=O
PDB

UniProtKB/SwissProt

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n/an/a 8.20n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


US Patent US9682968 (2017)


BindingDB Entry DOI: 10.7270/Q2XG9P9J
More data for this
Ligand-Target Pair
Complement factor B


(Homo sapiens (Human))
BDBM160490
PNG
(US10093663, Example 30-3 | US9682968, Example-30-2...)
Show SMILES COc1cc(C)c2[nH]ccc2c1CN1CC(O)CCC1c1ccc(cc1)C(O)=O
PDB

UniProtKB/SwissProt

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n/an/a 8.20n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


US Patent US9682968 (2017)


BindingDB Entry DOI: 10.7270/Q2XG9P9J
More data for this
Ligand-Target Pair
Complement factor B


(Homo sapiens (Human))
BDBM159192
PNG
(US10093663, Example 5-7 | US9682968, Example-5-7)
Show SMILES CNS(=O)(=O)c1cccc(c1)C1CCCCN1Cc1c(C)cc(C)c2[nH]ccc12
PDB

UniProtKB/SwissProt

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n/an/a 8.30n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


US Patent US9682968 (2017)


BindingDB Entry DOI: 10.7270/Q2XG9P9J
More data for this
Ligand-Target Pair
Complement factor B


(Homo sapiens (Human))
BDBM160472
PNG
(US10093663, Example 24 | US9682968, Example-24)
Show SMILES CCOC1CCN(Cc2c(OC)cc(C)c3[nH]ccc23)C(C1)c1ccc(cc1)C(N)=O
PDB

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n/an/a 8.70n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


US Patent US9682968 (2017)


BindingDB Entry DOI: 10.7270/Q2XG9P9J
More data for this
Ligand-Target Pair
Complement factor B


(Homo sapiens (Human))
BDBM159309
PNG
(US10093663, Example 15 | US9682968, Example-14 | U...)
Show SMILES COC1CCN(Cc2c(C)cc(C)c3[nH]ccc23)C(C1)c1ccc(cc1)C(=O)OC
PDB

UniProtKB/SwissProt

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n/an/a 8.70n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


US Patent US9682968 (2017)


BindingDB Entry DOI: 10.7270/Q2XG9P9J
More data for this
Ligand-Target Pair
Complement factor B


(Homo sapiens (Human))
BDBM159292
PNG
(US10093663, Example 7 | US9682968, Example-6 | US9...)
Show SMILES Cc1cc(C)c2[nH]ccc2c1CN1CCC(N)CC1c1ccccc1
PDB

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US Patent
n/an/a 9.40n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


US Patent US9682968 (2017)


BindingDB Entry DOI: 10.7270/Q2XG9P9J
More data for this
Ligand-Target Pair
Complement factor B


(Homo sapiens (Human))
BDBM159300
PNG
(US10093663, Example 10 | US9682968, Example-10)
Show SMILES COc1cc(C)c2[nH]ccc2c1CN1CCC(C)(CC1c1ccc(cc1)C(N)=O)OC
PDB

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n/an/a 11n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


US Patent US9682968 (2017)


BindingDB Entry DOI: 10.7270/Q2XG9P9J
More data for this
Ligand-Target Pair
Complement factor B


(Homo sapiens (Human))
BDBM159292
PNG
(US10093663, Example 7 | US9682968, Example-6 | US9...)
Show SMILES Cc1cc(C)c2[nH]ccc2c1CN1CCC(N)CC1c1ccccc1
PDB

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n/an/a 14n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


US Patent US9682968 (2017)


BindingDB Entry DOI: 10.7270/Q2XG9P9J
More data for this
Ligand-Target Pair
Complement factor B


(Homo sapiens (Human))
BDBM160473
PNG
(US10093663, Example 25b | US9682968, Example-25a (...)
Show SMILES Cc1cc(C)c2[nH]ccc2c1CN1CCCCC1c1ccc(cc1)C(O)=O
PDB

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n/an/a 15n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


US Patent US9682968 (2017)


BindingDB Entry DOI: 10.7270/Q2XG9P9J
More data for this
Ligand-Target Pair
Complement factor B


(Homo sapiens (Human))
BDBM160482
PNG
(US9682968, Example-27-2b (-))
Show SMILES CCOC1CCN(Cc2c(C)cc(C)c3[nH]ccc23)C(C1)c1ccc(cc1)C(O)=O
PDB

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US Patent
n/an/a 16n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


US Patent US9682968 (2017)


BindingDB Entry DOI: 10.7270/Q2XG9P9J
More data for this
Ligand-Target Pair
Complement factor B


(Homo sapiens (Human))
BDBM159216
PNG
(US10093663, Example 5-8 | US9682968, Example-5-8)
Show SMILES COC1CCN(Cc2c(C)cc(C)c3[nH]ccc23)C(C1)c1ccc(F)cc1
PDB

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n/an/a 24n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


US Patent US9682968 (2017)


BindingDB Entry DOI: 10.7270/Q2XG9P9J
More data for this
Ligand-Target Pair
Complement factor B


(Homo sapiens (Human))
BDBM159592
PNG
(US10093663, Example 17-19 | US9682968, Example-17-...)
Show SMILES COc1cc(C)c2[nH]ccc2c1CN1CCCCC1c1nc(cs1)C(O)=O
PDB

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n/an/a 29n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


US Patent US9682968 (2017)


BindingDB Entry DOI: 10.7270/Q2XG9P9J
More data for this
Ligand-Target Pair
Complement factor B


(Homo sapiens (Human))
BDBM160488
PNG
(US10093663, Example 29 | US9682968, Example-29)
Show SMILES COC1CCC(N(Cc2c(OC)cc(C)c3[nH]ccc23)C1)c1ccc(cc1)C(N)=O
PDB

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n/an/a 33n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


US Patent US9682968 (2017)


BindingDB Entry DOI: 10.7270/Q2XG9P9J
More data for this
Ligand-Target Pair
Complement factor B


(Homo sapiens (Human))
BDBM160494
PNG
(US10093663, Example 32-2 | US9682968, Example-32-2)
Show SMILES Cc1cc(C)c2[nH]ccc2c1CN1CCCCC1c1ccc(CN)cc1
PDB

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n/an/a 36n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


US Patent US9682968 (2017)


BindingDB Entry DOI: 10.7270/Q2XG9P9J
More data for this
Ligand-Target Pair
Complement factor B


(Homo sapiens (Human))
BDBM160492
PNG
(BDBM160493 | US10093663, Example 32-1 | US9682968,...)
Show SMILES CNC1CCN(Cc2c(C)cc(C)c3[nH]ccc23)C(C1)c1ccccc1
PDB

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n/an/a 36n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


US Patent US9682968 (2017)


BindingDB Entry DOI: 10.7270/Q2XG9P9J
More data for this
Ligand-Target Pair
Complement factor B


(Homo sapiens (Human))
BDBM159107
PNG
(US9682968, Example-4b (+))
Show SMILES COC1CCN(Cc2c(C)cc(C)c3[nH]ccc23)C(C1)c1ccccc1
PDB

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n/an/a 67n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


US Patent US9682968 (2017)


BindingDB Entry DOI: 10.7270/Q2XG9P9J
More data for this
Ligand-Target Pair
Complement factor B


(Homo sapiens (Human))
BDBM160293
PNG
(US10093663, Example 23b | US9682968, Example-23a (...)
Show SMILES CCOC1CCN(Cc2c(OC)cc(C)c3[nH]ccc23)C(C1)c1ccc(cc1)C#N
PDB

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n/an/a>100n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


US Patent US9682968 (2017)


BindingDB Entry DOI: 10.7270/Q2XG9P9J
More data for this
Ligand-Target Pair
Complement factor B


(Homo sapiens (Human))
BDBM159924
PNG
(US10093663, Example 17-27 | US9682968, Example-17-...)
Show SMILES COc1cc(C)c2[nH]ccc2c1C(N1CCCC[C@H]1c1ccc(cc1)C(O)=O)C(F)(F)F |r|
PDB

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n/an/a>100n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


US Patent US9682968 (2017)


BindingDB Entry DOI: 10.7270/Q2XG9P9J
More data for this
Ligand-Target Pair
Complement factor B


(Homo sapiens (Human))
BDBM159950
PNG
(US10093663, Example 19 | US9682968, Example-18 | U...)
Show SMILES Cc1cc(C)c2[nH]ccc2c1CN1CCC(CC#N)CC1c1ccccc1
PDB

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n/an/a>100n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


US Patent US9682968 (2017)


BindingDB Entry DOI: 10.7270/Q2XG9P9J
More data for this
Ligand-Target Pair
Complement factor B


(Homo sapiens (Human))
BDBM155872
PNG
(US10093663, Example 2b | US9682968, Example-1)
Show SMILES Cc1cc(C)c2[nH]ccc2c1CN1CCC(O)CC1c1ccccc1
PDB

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n/an/a>100n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


US Patent US9682968 (2017)


BindingDB Entry DOI: 10.7270/Q2XG9P9J
More data for this
Ligand-Target Pair
Complement factor B


(Homo sapiens (Human))
BDBM159100
PNG
(US9682968, Example-2b(+))
Show SMILES Cc1cc(C)c2[nH]ccc2c1CN1CCC(O)CC1c1ccccc1
PDB

UniProtKB/SwissProt

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US Patent
n/an/a>100n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


US Patent US9682968 (2017)


BindingDB Entry DOI: 10.7270/Q2XG9P9J
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%