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PubChem AID 579

Compile data set for download or QSAR
Found 47 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Dual specificity protein phosphatase 1


(Homo sapiens (Human))		BDBM33114
PNG
(2-(2-furanyl)-4-quinolinecarboxylic acid [2-[4-ami...)
Show SMILES Cn1c(=O)c(C(=O)COC(=O)c2cc(nc3ccccc23)-c2ccco2)c(N)n(Cc2ccccc2)c1=O
Show InChI InChI=1S/C28H22N4O6/c1-31-26(34)24(25(29)32(28(31)36)15-17-8-3-2-4-9-17)22(33)16-38-27(35)19-14-21(23-12-7-13-37-23)30-20-11-6-5-10-18(19)20/h2-14H,15-16,29H2,1H3
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n/an/a 1.34E+4n/an/an/an/a7.023



CC_PMLSC

Curated by PubChem BioAssay


Assay Description
The MKP-1 dose response assay SAR support Assay - has been developed to test the activity of a series Analog compounds synthesized by the PMLSC Chemi...

PubChem Bioassay (2007)


BindingDB Entry DOI: 10.7270/Q29G5K5D
More data for this
Ligand-Target Pair
Dual specificity protein phosphatase 1


(Homo sapiens (Human))		BDBM35479
PNG
(2-(2-furanyl)-4-quinolinecarboxylic acid [2-[6-ami...)
Show SMILES Cn1c(N)c(C(=O)COC(=O)c2cc(nc3ccccc23)-c2ccco2)c(=O)n(Cc2ccccc2)c1=O
Show InChI InChI=1S/C28H22N4O6/c1-31-25(29)24(26(34)32(28(31)36)15-17-8-3-2-4-9-17)22(33)16-38-27(35)19-14-21(23-12-7-13-37-23)30-20-11-6-5-10-18(19)20/h2-14H,15-16,29H2,1H3
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n/an/a 1.69E+4n/an/an/an/a7.023



CC_PMLSC

Curated by PubChem BioAssay


Assay Description
The MKP-1 dose response assay SAR support Assay - has been developed to test the activity of a series Analog compounds synthesized by the PMLSC Chemi...

PubChem Bioassay (2007)


BindingDB Entry DOI: 10.7270/Q29G5K5D
More data for this
Ligand-Target Pair
Dual specificity protein phosphatase 1


(Homo sapiens (Human))		BDBM35463
PNG
(2-(2-furanyl)-4-quinolinecarboxylic acid [2-(4-ami...)
Show SMILES Cn1c(N)c(C(=O)COC(=O)c2cc(nc3ccccc23)-c2ccco2)c(=O)n(C)c1=O
Show InChI InChI=1S/C22H18N4O6/c1-25-19(23)18(20(28)26(2)22(25)30)16(27)11-32-21(29)13-10-15(17-8-5-9-31-17)24-14-7-4-3-6-12(13)14/h3-10H,11,23H2,1-2H3
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n/an/a 2.06E+4n/an/an/an/a7.023



CC_PMLSC

Curated by PubChem BioAssay


Assay Description
The MKP-1 dose response assay SAR support Assay - has been developed to test the activity of a series Analog compounds synthesized by the PMLSC Chemi...

PubChem Bioassay (2007)


BindingDB Entry DOI: 10.7270/Q29G5K5D
More data for this
Ligand-Target Pair
Dual specificity protein phosphatase 1


(Homo sapiens (Human))		BDBM35484
PNG
(2-(2-furanyl)-4-quinolinecarboxylic acid [2-[6-ami...)
Show SMILES Cn1c(=O)c(C(=O)COC(=O)c2cc(nc3ccccc23)-c2ccco2)c(N)n(CC2CC2)c1=O
Show InChI InChI=1S/C25H22N4O6/c1-28-23(31)21(22(26)29(25(28)33)12-14-8-9-14)19(30)13-35-24(32)16-11-18(20-7-4-10-34-20)27-17-6-3-2-5-15(16)17/h2-7,10-11,14H,8-9,12-13,26H2,1H3
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n/an/a 2.46E+4n/an/an/an/a7.023



CC_PMLSC

Curated by PubChem BioAssay


Assay Description
The MKP-1 dose response assay SAR support Assay - has been developed to test the activity of a series Analog compounds synthesized by the PMLSC Chemi...

PubChem Bioassay (2007)


BindingDB Entry DOI: 10.7270/Q29G5K5D
More data for this
Ligand-Target Pair
Dual specificity protein phosphatase 1


(Homo sapiens (Human))		BDBM35480
PNG
(2-cyclopropyl-4-quinolinecarboxylic acid [2-[6-ami...)
Show SMILES Cn1c(N)c(C(=O)COC(=O)c2cc(nc3ccccc23)C2CC2)c(=O)n(Cc2ccccc2)c1=O
Show InChI InChI=1S/C27H24N4O5/c1-30-24(28)23(25(33)31(27(30)35)14-16-7-3-2-4-8-16)22(32)15-36-26(34)19-13-21(17-11-12-17)29-20-10-6-5-9-18(19)20/h2-10,13,17H,11-12,14-15,28H2,1H3
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n/an/a 2.89E+4n/an/an/an/a7.023



CC_PMLSC

Curated by PubChem BioAssay


Assay Description
The MKP-1 dose response assay SAR support Assay - has been developed to test the activity of a series Analog compounds synthesized by the PMLSC Chemi...

PubChem Bioassay (2007)


BindingDB Entry DOI: 10.7270/Q29G5K5D
More data for this
Ligand-Target Pair
Dual specificity protein phosphatase 1


(Homo sapiens (Human))		BDBM35456
PNG
(CC-PMLSC-DMA-P128 | N'-(2,6-diketo-3-methyl-pyrimi...)
Show SMILES CN(C)C=Nc1cc(=O)[nH]c(=O)n1C |w:4.4|
Show InChI InChI=1S/C8H12N4O2/c1-11(2)5-9-6-4-7(13)10-8(14)12(6)3/h4-5H,1-3H3,(H,10,13,14)
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n/an/a>5.00E+4n/an/an/an/a7.023



CC_PMLSC

Curated by PubChem BioAssay


Assay Description
The MKP-1 dose response assay SAR support Assay - has been developed to test the activity of a series Analog compounds synthesized by the PMLSC Chemi...

PubChem Bioassay (2007)


BindingDB Entry DOI: 10.7270/Q29G5K5D
More data for this
Ligand-Target Pair
Dual specificity protein phosphatase 1


(Homo sapiens (Human))		BDBM35467
PNG
(CC-PMLSC-DMA-P142 | N'-[3-(cyclopropylmethyl)-1-me...)
Show SMILES CN(C)\C=N\c1cc(=O)n(C)c(=O)n1CC1CC1
Show InChI InChI=1S/C12H18N4O2/c1-14(2)8-13-10-6-11(17)15(3)12(18)16(10)7-9-4-5-9/h6,8-9H,4-5,7H2,1-3H3/b13-8+
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n/an/a>5.00E+4n/an/an/an/a7.023



CC_PMLSC

Curated by PubChem BioAssay


Assay Description
The MKP-1 dose response assay SAR support Assay - has been developed to test the activity of a series Analog compounds synthesized by the PMLSC Chemi...

PubChem Bioassay (2007)


BindingDB Entry DOI: 10.7270/Q29G5K5D
More data for this
Ligand-Target Pair
Dual specificity protein phosphatase 1


(Homo sapiens (Human))		BDBM35474
PNG
(2-(trifluoromethyl)-4-quinolinecarboxylic acid [2-...)
Show SMILES Cn1c(=O)c(C(=O)COC(=O)c2cc(nc3ccccc23)C(F)(F)F)c(N)n(Cc2ccccc2)c1=O
Show InChI InChI=1S/C25H19F3N4O5/c1-31-22(34)20(21(29)32(24(31)36)12-14-7-3-2-4-8-14)18(33)13-37-23(35)16-11-19(25(26,27)28)30-17-10-6-5-9-15(16)17/h2-11H,12-13,29H2,1H3
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CC_PMLSC

Curated by PubChem BioAssay


Assay Description
The MKP-1 dose response assay SAR support Assay - has been developed to test the activity of a series Analog compounds synthesized by the PMLSC Chemi...

PubChem Bioassay (2007)


BindingDB Entry DOI: 10.7270/Q29G5K5D
More data for this
Ligand-Target Pair
Dual specificity protein phosphatase 1


(Homo sapiens (Human))		BDBM35444
PNG
(2-phenyl-4-quinolinecarboxylic acid [2-(4-amino-1,...)
Show SMILES Cn1c(N)c(C(=O)COC(=O)c2cc(nc3ccccc23)-c2ccccc2)c(=O)n(C)c1=O
Show InChI InChI=1S/C24H20N4O5/c1-27-21(25)20(22(30)28(2)24(27)32)19(29)13-33-23(31)16-12-18(14-8-4-3-5-9-14)26-17-11-7-6-10-15(16)17/h3-12H,13,25H2,1-2H3
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CC_PMLSC

Curated by PubChem BioAssay


Assay Description
The MKP-1 dose response assay SAR support Assay - has been developed to test the activity of a series Analog compounds synthesized by the PMLSC Chemi...

PubChem Bioassay (2007)


BindingDB Entry DOI: 10.7270/Q29G5K5D
More data for this
Ligand-Target Pair
Dual specificity protein phosphatase 1


(Homo sapiens (Human))		BDBM35454
PNG
(2-cyclopropyl-4-quinolinecarboxylic acid | 2-cyclo...)
Show SMILES OC(=O)c1cc(nc2ccccc12)C1CC1
Show InChI InChI=1S/C13H11NO2/c15-13(16)10-7-12(8-5-6-8)14-11-4-2-1-3-9(10)11/h1-4,7-8H,5-6H2,(H,15,16)
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n/an/a>5.00E+4n/an/an/an/a7.023



CC_PMLSC

Curated by PubChem BioAssay


Assay Description
The MKP-1 dose response assay SAR support Assay - has been developed to test the activity of a series Analog compounds synthesized by the PMLSC Chemi...

PubChem Bioassay (2007)


BindingDB Entry DOI: 10.7270/Q29G5K5D
More data for this
Ligand-Target Pair
Dual specificity protein phosphatase 1


(Homo sapiens (Human))		BDBM35472
PNG
(6-amino-3-benzyl-5-(2-chloroacetyl)-1-methyl-pyrim...)
Show SMILES Cn1c(N)c(C(=O)CCl)c(=O)n(Cc2ccccc2)c1=O
Show InChI InChI=1S/C14H14ClN3O3/c1-17-12(16)11(10(19)7-15)13(20)18(14(17)21)8-9-5-3-2-4-6-9/h2-6H,7-8,16H2,1H3
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n/an/a>5.00E+4n/an/an/an/a7.023



CC_PMLSC

Curated by PubChem BioAssay


Assay Description
The MKP-1 dose response assay SAR support Assay - has been developed to test the activity of a series Analog compounds synthesized by the PMLSC Chemi...

PubChem Bioassay (2007)


BindingDB Entry DOI: 10.7270/Q29G5K5D
More data for this
Ligand-Target Pair
Dual specificity protein phosphatase 1


(Homo sapiens (Human))		BDBM35477
PNG
(2-(trifluoromethyl)-4-quinolinecarboxylic acid [2-...)
Show SMILES Cn1c(N)c(C(=O)COC(=O)c2cc(nc3ccccc23)C(F)(F)F)c(=O)n(Cc2ccccc2)c1=O
Show InChI InChI=1S/C25H19F3N4O5/c1-31-21(29)20(22(34)32(24(31)36)12-14-7-3-2-4-8-14)18(33)13-37-23(35)16-11-19(25(26,27)28)30-17-10-6-5-9-15(16)17/h2-11H,12-13,29H2,1H3
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n/an/a>5.00E+4n/an/an/an/a7.023



CC_PMLSC

Curated by PubChem BioAssay


Assay Description
The MKP-1 dose response assay SAR support Assay - has been developed to test the activity of a series Analog compounds synthesized by the PMLSC Chemi...

PubChem Bioassay (2007)


BindingDB Entry DOI: 10.7270/Q29G5K5D
More data for this
Ligand-Target Pair
Dual specificity protein phosphatase 1


(Homo sapiens (Human))		BDBM35485
PNG
(2,8-bis(trifluoromethyl)-4-quinolinecarboxylic aci...)
Show SMILES Cn1c(=O)c(C(=O)COC(=O)c2cc(nc3c(cccc23)C(F)(F)F)C(F)(F)F)c(N)n(CC2CC2)c1=O
Show InChI InChI=1S/C23H18F6N4O5/c1-32-19(35)16(18(30)33(21(32)37)8-10-5-6-10)14(34)9-38-20(36)12-7-15(23(27,28)29)31-17-11(12)3-2-4-13(17)22(24,25)26/h2-4,7,10H,5-6,8-9,30H2,1H3
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CC_PMLSC

Curated by PubChem BioAssay


Assay Description
The MKP-1 dose response assay SAR support Assay - has been developed to test the activity of a series Analog compounds synthesized by the PMLSC Chemi...

PubChem Bioassay (2007)


BindingDB Entry DOI: 10.7270/Q29G5K5D
More data for this
Ligand-Target Pair
Dual specificity protein phosphatase 1


(Homo sapiens (Human))		BDBM35443
PNG
(6-amino-5-(2-chloro-1-oxoethyl)-3-methyl-1-(2-meth...)
Show SMILES CC(C)Cn1c(N)c(C(=O)CCl)c(=O)n(C)c1=O
Show InChI InChI=1S/C11H16ClN3O3/c1-6(2)5-15-9(13)8(7(16)4-12)10(17)14(3)11(15)18/h6H,4-5,13H2,1-3H3
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CC_PMLSC

Curated by PubChem BioAssay


Assay Description
The MKP-1 dose response assay SAR support Assay - has been developed to test the activity of a series Analog compounds synthesized by the PMLSC Chemi...

PubChem Bioassay (2007)


BindingDB Entry DOI: 10.7270/Q29G5K5D
More data for this
Ligand-Target Pair
Dual specificity protein phosphatase 1


(Homo sapiens (Human))		BDBM35452
PNG
(2,8-bis(trifluoromethyl)-4-quinolinecarboxylic aci...)
Show SMILES OC(=O)c1cc(nc2c(cccc12)C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C12H5F6NO2/c13-11(14,15)7-3-1-2-5-6(10(20)21)4-8(12(16,17)18)19-9(5)7/h1-4H,(H,20,21)
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CC_PMLSC

Curated by PubChem BioAssay


Assay Description
The MKP-1 dose response assay SAR support Assay - has been developed to test the activity of a series Analog compounds synthesized by the PMLSC Chemi...

PubChem Bioassay (2007)


BindingDB Entry DOI: 10.7270/Q29G5K5D
More data for this
Ligand-Target Pair
Dual specificity protein phosphatase 1


(Homo sapiens (Human))		BDBM35483
PNG
(6-amino-5-(2-chloro-1-oxoethyl)-1-(cyclopropylmeth...)
Show SMILES Cn1c(=O)c(C(=O)CCl)c(N)n(CC2CC2)c1=O
Show InChI InChI=1S/C11H14ClN3O3/c1-14-10(17)8(7(16)4-12)9(13)15(11(14)18)5-6-2-3-6/h6H,2-5,13H2,1H3
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CC_PMLSC

Curated by PubChem BioAssay


Assay Description
The MKP-1 dose response assay SAR support Assay - has been developed to test the activity of a series Analog compounds synthesized by the PMLSC Chemi...

PubChem Bioassay (2007)


BindingDB Entry DOI: 10.7270/Q29G5K5D
More data for this
Ligand-Target Pair
Dual specificity protein phosphatase 1


(Homo sapiens (Human))		BDBM35441
PNG
(6-amino-5-(2-chloro-1-oxoethyl)-1,3-dimethylpyrimi...)
Show SMILES Cn1c(N)c(C(=O)CCl)c(=O)n(C)c1=O
Show InChI InChI=1S/C8H10ClN3O3/c1-11-6(10)5(4(13)3-9)7(14)12(2)8(11)15/h3,10H2,1-2H3
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CC_PMLSC

Curated by PubChem BioAssay


Assay Description
The MKP-1 dose response assay SAR support Assay - has been developed to test the activity of a series Analog compounds synthesized by the PMLSC Chemi...

PubChem Bioassay (2007)


BindingDB Entry DOI: 10.7270/Q29G5K5D
More data for this
Ligand-Target Pair
Dual specificity protein phosphatase 1


(Homo sapiens (Human))		BDBM35442
PNG
(4-quinolinecarboxylic acid [2-(4-amino-1,3-dimethy...)
Show SMILES Cn1c(N)c(C(=O)COC(=O)c2ccnc3ccccc23)c(=O)n(C)c1=O
Show InChI InChI=1S/C18H16N4O5/c1-21-15(19)14(16(24)22(2)18(21)26)13(23)9-27-17(25)11-7-8-20-12-6-4-3-5-10(11)12/h3-8H,9,19H2,1-2H3
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CC_PMLSC

Curated by PubChem BioAssay


Assay Description
The MKP-1 dose response assay SAR support Assay - has been developed to test the activity of a series Analog compounds synthesized by the PMLSC Chemi...

PubChem Bioassay (2007)


BindingDB Entry DOI: 10.7270/Q29G5K5D
More data for this
Ligand-Target Pair
Dual specificity protein phosphatase 1


(Homo sapiens (Human))		BDBM35445
PNG
(2-phenyl-4-quinolinecarboxylic acid [2-[4-amino-1-...)
Show SMILES CC(C)Cn1c(N)c(C(=O)COC(=O)c2cc(nc3ccccc23)-c2ccccc2)c(=O)n(C)c1=O
Show InChI InChI=1S/C27H26N4O5/c1-16(2)14-31-24(28)23(25(33)30(3)27(31)35)22(32)15-36-26(34)19-13-21(17-9-5-4-6-10-17)29-20-12-8-7-11-18(19)20/h4-13,16H,14-15,28H2,1-3H3
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CC_PMLSC

Curated by PubChem BioAssay


Assay Description
The MKP-1 dose response assay SAR support Assay - has been developed to test the activity of a series Analog compounds synthesized by the PMLSC Chemi...

PubChem Bioassay (2007)


BindingDB Entry DOI: 10.7270/Q29G5K5D
More data for this
Ligand-Target Pair
Dual specificity protein phosphatase 1


(Homo sapiens (Human))		BDBM35453
PNG
(2-(2-furanyl)-4-quinolinecarboxylic acid | 2-(2-fu...)
Show SMILES OC(=O)c1cc(nc2ccccc12)-c1ccco1
Show InChI InChI=1S/C14H9NO3/c16-14(17)10-8-12(13-6-3-7-18-13)15-11-5-2-1-4-9(10)11/h1-8H,(H,16,17)
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CC_PMLSC

Curated by PubChem BioAssay


Assay Description
The MKP-1 dose response assay SAR support Assay - has been developed to test the activity of a series Analog compounds synthesized by the PMLSC Chemi...

PubChem Bioassay (2007)


BindingDB Entry DOI: 10.7270/Q29G5K5D
More data for this
Ligand-Target Pair
Dual specificity protein phosphatase 1


(Homo sapiens (Human))		BDBM35462
PNG
(6-amino-1-methyl-3-(phenylmethyl)pyrimidine-2,4-di...)
Show SMILES Cn1c(N)cc(=O)n(Cc2ccccc2)c1=O
Show InChI InChI=1S/C12H13N3O2/c1-14-10(13)7-11(16)15(12(14)17)8-9-5-3-2-4-6-9/h2-7H,8,13H2,1H3
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CC_PMLSC

Curated by PubChem BioAssay


Assay Description
The MKP-1 dose response assay SAR support Assay - has been developed to test the activity of a series Analog compounds synthesized by the PMLSC Chemi...

PubChem Bioassay (2007)


BindingDB Entry DOI: 10.7270/Q29G5K5D
More data for this
Ligand-Target Pair
Dual specificity protein phosphatase 1


(Homo sapiens (Human))		BDBM35475
PNG
(2,8-bis(trifluoromethyl)-4-quinolinecarboxylic aci...)
Show SMILES Cn1c(=O)c(C(=O)COC(=O)c2cc(nc3c(cccc23)C(F)(F)F)C(F)(F)F)c(N)n(Cc2ccccc2)c1=O
Show InChI InChI=1S/C26H18F6N4O5/c1-35-22(38)19(21(33)36(24(35)40)11-13-6-3-2-4-7-13)17(37)12-41-23(39)15-10-18(26(30,31)32)34-20-14(15)8-5-9-16(20)25(27,28)29/h2-10H,11-12,33H2,1H3
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CC_PMLSC

Curated by PubChem BioAssay


Assay Description
The MKP-1 dose response assay SAR support Assay - has been developed to test the activity of a series Analog compounds synthesized by the PMLSC Chemi...

PubChem Bioassay (2007)


BindingDB Entry DOI: 10.7270/Q29G5K5D
More data for this
Ligand-Target Pair
Dual specificity protein phosphatase 1


(Homo sapiens (Human))		BDBM35449
PNG
(6-amino-1-(phenylmethyl)pyrimidine-2,4-dione | 6-a...)
Show SMILES Nc1cc(=O)[nH]c(=O)n1Cc1ccccc1
Show InChI InChI=1S/C11H11N3O2/c12-9-6-10(15)13-11(16)14(9)7-8-4-2-1-3-5-8/h1-6H,7,12H2,(H,13,15,16)
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CC_PMLSC

Curated by PubChem BioAssay


Assay Description
The MKP-1 dose response assay SAR support Assay - has been developed to test the activity of a series Analog compounds synthesized by the PMLSC Chemi...

PubChem Bioassay (2007)


BindingDB Entry DOI: 10.7270/Q29G5K5D
More data for this
Ligand-Target Pair
Dual specificity protein phosphatase 1


(Homo sapiens (Human))		BDBM35459
PNG
(CC-PMLSC-DMA-P131 | N'-(1-benzyl-2,6-diketo-3-meth...)
Show SMILES CN(C)\C=N\c1cc(=O)n(Cc2ccccc2)c(=O)n1C
Show InChI InChI=1S/C15H18N4O2/c1-17(2)11-16-13-9-14(20)19(15(21)18(13)3)10-12-7-5-4-6-8-12/h4-9,11H,10H2,1-3H3/b16-11+
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CC_PMLSC

Curated by PubChem BioAssay


Assay Description
The MKP-1 dose response assay SAR support Assay - has been developed to test the activity of a series Analog compounds synthesized by the PMLSC Chemi...

PubChem Bioassay (2007)


BindingDB Entry DOI: 10.7270/Q29G5K5D
More data for this
Ligand-Target Pair
Dual specificity protein phosphatase 1


(Homo sapiens (Human))		BDBM35460
PNG
(6-amino-1-(cyclopropylmethyl)pyrimidine-2,4-dione ...)
Show SMILES Nc1cc(=O)[nH]c(=O)n1CC1CC1
Show InChI InChI=1S/C8H11N3O2/c9-6-3-7(12)10-8(13)11(6)4-5-1-2-5/h3,5H,1-2,4,9H2,(H,10,12,13)
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CC_PMLSC

Curated by PubChem BioAssay


Assay Description
The MKP-1 dose response assay SAR support Assay - has been developed to test the activity of a series Analog compounds synthesized by the PMLSC Chemi...

PubChem Bioassay (2007)


BindingDB Entry DOI: 10.7270/Q29G5K5D
More data for this
Ligand-Target Pair
Dual specificity protein phosphatase 1


(Homo sapiens (Human))		BDBM35468
PNG
(6-amino-1-benzyl-5-(2-chloroacetyl)-3-methyl-pyrim...)
Show SMILES Cn1c(=O)c(C(=O)CCl)c(N)n(Cc2ccccc2)c1=O
Show InChI InChI=1S/C14H14ClN3O3/c1-17-13(20)11(10(19)7-15)12(16)18(14(17)21)8-9-5-3-2-4-6-9/h2-6H,7-8,16H2,1H3
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CC_PMLSC

Curated by PubChem BioAssay


Assay Description
The MKP-1 dose response assay SAR support Assay - has been developed to test the activity of a series Analog compounds synthesized by the PMLSC Chemi...

PubChem Bioassay (2007)


BindingDB Entry DOI: 10.7270/Q29G5K5D
More data for this
Ligand-Target Pair
Dual specificity protein phosphatase 1


(Homo sapiens (Human))		BDBM35469
PNG
(2-(trifluoromethyl)-4-quinolinecarboxylic acid [2-...)
Show SMILES Cn1c(N)c(C(=O)COC(=O)c2cc(nc3ccccc23)C(F)(F)F)c(=O)n(C)c1=O
Show InChI InChI=1S/C19H15F3N4O5/c1-25-15(23)14(16(28)26(2)18(25)30)12(27)8-31-17(29)10-7-13(19(20,21)22)24-11-6-4-3-5-9(10)11/h3-7H,8,23H2,1-2H3
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CC_PMLSC

Curated by PubChem BioAssay


Assay Description
The MKP-1 dose response assay SAR support Assay - has been developed to test the activity of a series Analog compounds synthesized by the PMLSC Chemi...

PubChem Bioassay (2007)


BindingDB Entry DOI: 10.7270/Q29G5K5D
More data for this
Ligand-Target Pair
Dual specificity protein phosphatase 1


(Homo sapiens (Human))		BDBM35471
PNG
(2-phenyl-4-quinolinecarboxylic acid [2-[4-amino-1-...)
Show SMILES Cn1c(=O)c(C(=O)COC(=O)c2cc(nc3ccccc23)-c2ccccc2)c(N)n(Cc2ccccc2)c1=O
Show InChI InChI=1S/C30H24N4O5/c1-33-28(36)26(27(31)34(30(33)38)17-19-10-4-2-5-11-19)25(35)18-39-29(37)22-16-24(20-12-6-3-7-13-20)32-23-15-9-8-14-21(22)23/h2-16H,17-18,31H2,1H3
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CC_PMLSC

Curated by PubChem BioAssay


Assay Description
The MKP-1 dose response assay SAR support Assay - has been developed to test the activity of a series Analog compounds synthesized by the PMLSC Chemi...

PubChem Bioassay (2007)


BindingDB Entry DOI: 10.7270/Q29G5K5D
More data for this
Ligand-Target Pair
Dual specificity protein phosphatase 1


(Homo sapiens (Human))		BDBM35446
PNG
(2,8-bis(trifluoromethyl)-1H-quinolin-4-one | 2,8-b...)
Show SMILES Oc1cc(nc2c(cccc12)C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C11H5F6NO/c12-10(13,14)6-3-1-2-5-7(19)4-8(11(15,16)17)18-9(5)6/h1-4H,(H,18,19)
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CC_PMLSC

Curated by PubChem BioAssay


Assay Description
The MKP-1 dose response assay SAR support Assay - has been developed to test the activity of a series Analog compounds synthesized by the PMLSC Chemi...

PubChem Bioassay (2007)


BindingDB Entry DOI: 10.7270/Q29G5K5D
More data for this
Ligand-Target Pair
Dual specificity protein phosphatase 1


(Homo sapiens (Human))		BDBM35379
PNG
(2-(2-furanyl)-4-quinolinecarboxylic acid [2-[4-ami...)
Show SMILES CC(C)Cn1c(N)c(C(=O)COC(=O)c2cc(nc3ccccc23)-c2ccco2)c(=O)n(C)c1=O
Show InChI InChI=1S/C25H24N4O6/c1-14(2)12-29-22(26)21(23(31)28(3)25(29)33)19(30)13-35-24(32)16-11-18(20-9-6-10-34-20)27-17-8-5-4-7-15(16)17/h4-11,14H,12-13,26H2,1-3H3
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CC_PMLSC

Curated by PubChem BioAssay


Assay Description
The MKP-1 dose response assay SAR support Assay - has been developed to test the activity of a series Analog compounds synthesized by the PMLSC Chemi...

PubChem Bioassay (2007)


BindingDB Entry DOI: 10.7270/Q29G5K5D
More data for this
Ligand-Target Pair
Dual specificity protein phosphatase 1


(Homo sapiens (Human))		BDBM35457
PNG
(CC-PMLSC-DMA-P129 | N'-(3-benzyl-1-methyl-2,6-diox...)
Show SMILES CN(C)\C=N\c1cc(=O)n(C)c(=O)n1Cc1ccccc1
Show InChI InChI=1S/C15H18N4O2/c1-17(2)11-16-13-9-14(20)18(3)15(21)19(13)10-12-7-5-4-6-8-12/h4-9,11H,10H2,1-3H3/b16-11+
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CC_PMLSC

Curated by PubChem BioAssay


Assay Description
The MKP-1 dose response assay SAR support Assay - has been developed to test the activity of a series Analog compounds synthesized by the PMLSC Chemi...

PubChem Bioassay (2007)


BindingDB Entry DOI: 10.7270/Q29G5K5D
More data for this
Ligand-Target Pair
Dual specificity protein phosphatase 1


(Homo sapiens (Human))		BDBM35458
PNG
(2-cyano-N-(cyclopropylmethylcarbamoyl)acetamide | ...)
Show SMILES O=C(CC#N)NC(=O)NCC1CC1
Show InChI InChI=1S/C8H11N3O2/c9-4-3-7(12)11-8(13)10-5-6-1-2-6/h6H,1-3,5H2,(H2,10,11,12,13)
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CC_PMLSC

Curated by PubChem BioAssay


Assay Description
The MKP-1 dose response assay SAR support Assay - has been developed to test the activity of a series Analog compounds synthesized by the PMLSC Chemi...

PubChem Bioassay (2007)


BindingDB Entry DOI: 10.7270/Q29G5K5D
More data for this
Ligand-Target Pair
Dual specificity protein phosphatase 1


(Homo sapiens (Human))		BDBM35461
PNG
(6-amino-1-benzyl-3-methyl-pyrimidine-2,4-quinone |...)
Show SMILES Cn1c(=O)cc(N)n(Cc2ccccc2)c1=O
Show InChI InChI=1S/C12H13N3O2/c1-14-11(16)7-10(13)15(12(14)17)8-9-5-3-2-4-6-9/h2-7H,8,13H2,1H3
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CC_PMLSC

Curated by PubChem BioAssay


Assay Description
The MKP-1 dose response assay SAR support Assay - has been developed to test the activity of a series Analog compounds synthesized by the PMLSC Chemi...

PubChem Bioassay (2007)


BindingDB Entry DOI: 10.7270/Q29G5K5D
More data for this
Ligand-Target Pair
Dual specificity protein phosphatase 1


(Homo sapiens (Human))		BDBM35464
PNG
(CC-PMLSC- DMA-P139 | N'-[3-(cyclopropylmethyl)-2,6...)
Show SMILES CN(C)C=Nc1cc(=O)[nH]c(=O)n1CC1CC1 |w:4.4|
Show InChI InChI=1S/C11H16N4O2/c1-14(2)7-12-9-5-10(16)13-11(17)15(9)6-8-3-4-8/h5,7-8H,3-4,6H2,1-2H3,(H,13,16,17)
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CC_PMLSC

Curated by PubChem BioAssay


Assay Description
The MKP-1 dose response assay SAR support Assay - has been developed to test the activity of a series Analog compounds synthesized by the PMLSC Chemi...

PubChem Bioassay (2007)


BindingDB Entry DOI: 10.7270/Q29G5K5D
More data for this
Ligand-Target Pair
Dual specificity protein phosphatase 1


(Homo sapiens (Human))		BDBM35465
PNG
(2-cyclopropyl-4-quinolinecarboxylic acid [2-(4-ami...)
Show SMILES Cn1c(N)c(C(=O)COC(=O)c2cc(nc3ccccc23)C2CC2)c(=O)n(C)c1=O
Show InChI InChI=1S/C21H20N4O5/c1-24-18(22)17(19(27)25(2)21(24)29)16(26)10-30-20(28)13-9-15(11-7-8-11)23-14-6-4-3-5-12(13)14/h3-6,9,11H,7-8,10,22H2,1-2H3
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CC_PMLSC

Curated by PubChem BioAssay


Assay Description
The MKP-1 dose response assay SAR support Assay - has been developed to test the activity of a series Analog compounds synthesized by the PMLSC Chemi...

PubChem Bioassay (2007)


BindingDB Entry DOI: 10.7270/Q29G5K5D
More data for this
Ligand-Target Pair
Dual specificity protein phosphatase 1


(Homo sapiens (Human))		BDBM35478
PNG
(2,8-bis(trifluoromethyl)-4-quinolinecarboxylic aci...)
Show SMILES Cn1c(N)c(C(=O)COC(=O)c2cc(nc3c(cccc23)C(F)(F)F)C(F)(F)F)c(=O)n(Cc2ccccc2)c1=O
Show InChI InChI=1S/C26H18F6N4O5/c1-35-21(33)19(22(38)36(24(35)40)11-13-6-3-2-4-7-13)17(37)12-41-23(39)15-10-18(26(30,31)32)34-20-14(15)8-5-9-16(20)25(27,28)29/h2-10H,11-12,33H2,1H3
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CC_PMLSC

Curated by PubChem BioAssay


Assay Description
The MKP-1 dose response assay SAR support Assay - has been developed to test the activity of a series Analog compounds synthesized by the PMLSC Chemi...

PubChem Bioassay (2007)


BindingDB Entry DOI: 10.7270/Q29G5K5D
More data for this
Ligand-Target Pair
Dual specificity protein phosphatase 1


(Homo sapiens (Human))		BDBM35451
PNG
(2-(trifluoromethyl)-4-quinolinecarboxylic acid | 2...)
Show SMILES OC(=O)c1cc(nc2ccccc12)C(F)(F)F
Show InChI InChI=1S/C11H6F3NO2/c12-11(13,14)9-5-7(10(16)17)6-3-1-2-4-8(6)15-9/h1-5H,(H,16,17)
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CC_PMLSC

Curated by PubChem BioAssay


Assay Description
The MKP-1 dose response assay SAR support Assay - has been developed to test the activity of a series Analog compounds synthesized by the PMLSC Chemi...

PubChem Bioassay (2007)


BindingDB Entry DOI: 10.7270/Q29G5K5D
More data for this
Ligand-Target Pair
Dual specificity protein phosphatase 1


(Homo sapiens (Human))		BDBM35455
PNG
(1-(cyclopropylmethyl)urea | CC-PMLSC-DMA-P126 | ci...)
Show SMILES NC(=O)NCC1CC1
Show InChI InChI=1S/C5H10N2O/c6-5(8)7-3-4-1-2-4/h4H,1-3H2,(H3,6,7,8)
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CC_PMLSC

Curated by PubChem BioAssay


Assay Description
The MKP-1 dose response assay SAR support Assay - has been developed to test the activity of a series Analog compounds synthesized by the PMLSC Chemi...

PubChem Bioassay (2007)


BindingDB Entry DOI: 10.7270/Q29G5K5D
More data for this
Ligand-Target Pair
Dual specificity protein phosphatase 1


(Homo sapiens (Human))		BDBM35470
PNG
(2,8-bis(trifluoromethyl)-4-quinolinecarboxylic aci...)
Show SMILES Cn1c(N)c(C(=O)COC(=O)c2cc(nc3c(cccc23)C(F)(F)F)C(F)(F)F)c(=O)n(C)c1=O
Show InChI InChI=1S/C20H14F6N4O5/c1-29-15(27)13(16(32)30(2)18(29)34)11(31)7-35-17(33)9-6-12(20(24,25)26)28-14-8(9)4-3-5-10(14)19(21,22)23/h3-6H,7,27H2,1-2H3
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CC_PMLSC

Curated by PubChem BioAssay


Assay Description
The MKP-1 dose response assay SAR support Assay - has been developed to test the activity of a series Analog compounds synthesized by the PMLSC Chemi...

PubChem Bioassay (2007)


BindingDB Entry DOI: 10.7270/Q29G5K5D
More data for this
Ligand-Target Pair
Dual specificity protein phosphatase 1


(Homo sapiens (Human))		BDBM35473
PNG
(2,8-bis(trifluoromethyl)-4-quinolinecarboxylic aci...)
Show SMILES CC(C)Cn1c(N)c(C(=O)COC(=O)c2cc(nc3c(cccc23)C(F)(F)F)C(F)(F)F)c(=O)n(C)c1=O
Show InChI InChI=1S/C23H20F6N4O5/c1-10(2)8-33-18(30)16(19(35)32(3)21(33)37)14(34)9-38-20(36)12-7-15(23(27,28)29)31-17-11(12)5-4-6-13(17)22(24,25)26/h4-7,10H,8-9,30H2,1-3H3
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CC_PMLSC

Curated by PubChem BioAssay


Assay Description
The MKP-1 dose response assay SAR support Assay - has been developed to test the activity of a series Analog compounds synthesized by the PMLSC Chemi...

PubChem Bioassay (2007)


BindingDB Entry DOI: 10.7270/Q29G5K5D
More data for this
Ligand-Target Pair
Dual specificity protein phosphatase 1


(Homo sapiens (Human))		BDBM35476
PNG
(2-cyclopropyl-4-quinolinecarboxylic acid [2-[4-ami...)
Show SMILES Cn1c(=O)c(C(=O)COC(=O)c2cc(nc3ccccc23)C2CC2)c(N)n(Cc2ccccc2)c1=O
Show InChI InChI=1S/C27H24N4O5/c1-30-25(33)23(24(28)31(27(30)35)14-16-7-3-2-4-8-16)22(32)15-36-26(34)19-13-21(17-11-12-17)29-20-10-6-5-9-18(19)20/h2-10,13,17H,11-12,14-15,28H2,1H3
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n/an/a>5.00E+4n/an/an/an/a7.023



CC_PMLSC

Curated by PubChem BioAssay


Assay Description
The MKP-1 dose response assay SAR support Assay - has been developed to test the activity of a series Analog compounds synthesized by the PMLSC Chemi...

PubChem Bioassay (2007)


BindingDB Entry DOI: 10.7270/Q29G5K5D
More data for this
Ligand-Target Pair
Dual specificity protein phosphatase 1


(Homo sapiens (Human))		BDBM35448
PNG
(4-bromanyl-2,8-bis(trifluoromethyl)quinoline | 4-b...)
Show SMILES FC(F)(F)c1cc(Br)c2cccc(c2n1)C(F)(F)F
Show InChI InChI=1S/C11H4BrF6N/c12-7-4-8(11(16,17)18)19-9-5(7)2-1-3-6(9)10(13,14)15/h1-4H
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n/an/a>5.00E+4n/an/an/an/a7.023



CC_PMLSC

Curated by PubChem BioAssay


Assay Description
The MKP-1 dose response assay SAR support Assay - has been developed to test the activity of a series Analog compounds synthesized by the PMLSC Chemi...

PubChem Bioassay (2007)


BindingDB Entry DOI: 10.7270/Q29G5K5D
More data for this
Ligand-Target Pair
Dual specificity protein phosphatase 1


(Homo sapiens (Human))		BDBM35447
PNG
((phenylmethyl)urea | 1-(phenylmethyl)urea | CC-PML...)
Show SMILES NC(=O)NCc1ccccc1
Show InChI InChI=1S/C8H10N2O/c9-8(11)10-6-7-4-2-1-3-5-7/h1-5H,6H2,(H3,9,10,11)
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n/an/a>5.00E+4n/an/an/an/a7.023



CC_PMLSC

Curated by PubChem BioAssay


Assay Description
The MKP-1 dose response assay SAR support Assay - has been developed to test the activity of a series Analog compounds synthesized by the PMLSC Chemi...

PubChem Bioassay (2007)


BindingDB Entry DOI: 10.7270/Q29G5K5D
More data for this
Ligand-Target Pair
Dual specificity protein phosphatase 1


(Homo sapiens (Human))		BDBM35481
PNG
(2-phenyl-4-quinolinecarboxylic acid [2-[6-amino-1-...)
Show SMILES Cn1c(N)c(C(=O)COC(=O)c2cc(nc3ccccc23)-c2ccccc2)c(=O)n(Cc2ccccc2)c1=O
Show InChI InChI=1S/C30H24N4O5/c1-33-27(31)26(28(36)34(30(33)38)17-19-10-4-2-5-11-19)25(35)18-39-29(37)22-16-24(20-12-6-3-7-13-20)32-23-15-9-8-14-21(22)23/h2-16H,17-18,31H2,1H3
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CC_PMLSC

Curated by PubChem BioAssay


Assay Description
The MKP-1 dose response assay SAR support Assay - has been developed to test the activity of a series Analog compounds synthesized by the PMLSC Chemi...

PubChem Bioassay (2007)


BindingDB Entry DOI: 10.7270/Q29G5K5D
More data for this
Ligand-Target Pair
Dual specificity protein phosphatase 1


(Homo sapiens (Human))		BDBM35482
PNG
(2-(trifluoromethyl)-4-quinolinecarboxylic acid [2-...)
Show SMILES CC(C)Cn1c(N)c(C(=O)COC(=O)c2cc(nc3ccccc23)C(F)(F)F)c(=O)n(C)c1=O
Show InChI InChI=1S/C22H21F3N4O5/c1-11(2)9-29-18(26)17(19(31)28(3)21(29)33)15(30)10-34-20(32)13-8-16(22(23,24)25)27-14-7-5-4-6-12(13)14/h4-8,11H,9-10,26H2,1-3H3
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n/an/a>5.00E+4n/an/an/an/a7.023



CC_PMLSC

Curated by PubChem BioAssay


Assay Description
The MKP-1 dose response assay SAR support Assay - has been developed to test the activity of a series Analog compounds synthesized by the PMLSC Chemi...

PubChem Bioassay (2007)


BindingDB Entry DOI: 10.7270/Q29G5K5D
More data for this
Ligand-Target Pair
Dual specificity protein phosphatase 1


(Homo sapiens (Human))		BDBM35450
PNG
(CC-PMLSC-DMA-P113 | N'-(3-benzyl-2,6-diketo-pyrimi...)
Show SMILES CN(C)C=Nc1cc(=O)[nH]c(=O)n1Cc1ccccc1 |w:4.4|
Show InChI InChI=1S/C14H16N4O2/c1-17(2)10-15-12-8-13(19)16-14(20)18(12)9-11-6-4-3-5-7-11/h3-8,10H,9H2,1-2H3,(H,16,19,20)
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n/an/a>5.00E+4n/an/an/an/a7.023



CC_PMLSC

Curated by PubChem BioAssay


Assay Description
The MKP-1 dose response assay SAR support Assay - has been developed to test the activity of a series Analog compounds synthesized by the PMLSC Chemi...

PubChem Bioassay (2007)


BindingDB Entry DOI: 10.7270/Q29G5K5D
More data for this
Ligand-Target Pair
Dual specificity protein phosphatase 1


(Homo sapiens (Human))		BDBM35466
PNG
(2-cyclopropyl-4-quinolinecarboxylic acid [2-[4-ami...)
Show SMILES CC(C)Cn1c(N)c(C(=O)COC(=O)c2cc(nc3ccccc23)C2CC2)c(=O)n(C)c1=O
Show InChI InChI=1S/C24H26N4O5/c1-13(2)11-28-21(25)20(22(30)27(3)24(28)32)19(29)12-33-23(31)16-10-18(14-8-9-14)26-17-7-5-4-6-15(16)17/h4-7,10,13-14H,8-9,11-12,25H2,1-3H3
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n/an/a>5.00E+4n/an/an/an/a7.023



CC_PMLSC

Curated by PubChem BioAssay


Assay Description
The MKP-1 dose response assay SAR support Assay - has been developed to test the activity of a series Analog compounds synthesized by the PMLSC Chemi...

PubChem Bioassay (2007)


BindingDB Entry DOI: 10.7270/Q29G5K5D
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%