Reaction Details | |||
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Cell Reactant: | Thymidine Kinase (TK.dT) | ||
Syringe Reactant: | BDBM2 | ||
Meas. Tech.: | ITC | ||
Entry Date: | 12/13/00 | ||
ΔG°: | -37.8±1.47 (kJ/mole) | ||
pH: | 7.5±n/a | ||
Log10Kb: | 6.59± n/a | ||
Temperature: | 298.15±n/a (K) | ||
ΔH° : | -58.0±2.90 (kJ/mole) | ||
ΔHobs: | n/a | ||
Ionic Strength: | n/a | ||
yes | |||
Protons Released: | -0.31 | ||
ΔCp : | -0.588±0.084 (kJ/mole) | ||
Stoich. Param.: | n/a | ||
ΔS° : | -0.067±0.0210 (kJ/mole-K) | ||
Comments: | n/a | ||
Citation | Perozzo, R; Jelesarov, I; Bosshard, HR; Folkers, G; Scapozza, L Compulsory order of substrate binding to herpes simplex virus type 1 thymidine kinase. A calorimetric study. J Biol Chem275:16139-45 (2000) [PubMed] Article | ||
More Info.: | Get all data from this article , ITC RUN data , Solution Info , Instrument Info | ||
Thymidine Kinase (TK.dT) | |||
Source: | n/a | ||
Purity: | More than 99% of the enzyme was present as TK.dT complex | ||
Prep. Method: | 0.0373 mM enzyme exists in the presence of 1 mM dT. | ||
Name: | Thymidine Kinase (TK.dT) | ||
Synonyms: | thymidine kinase and thymidine complex (TK.dT) | ||
Type: | Protein Complex | ||
Mol. Mass.: | n/a | ||
Description: | n/a | ||
Components: | This complex has 2 components. | ||
Component 1 | |||
Name: | Thymidine kinase | ||
Synonyms: | KITH_HHV11 | TK | ||
Type: | Enzyme | ||
Mol. Mass.: | 40978.57 | ||
Organism: | Human herpesvirus 1 | ||
Description: | P03176 | ||
Residue: | 376 | ||
Sequence: |
| ||
Component 2 | |||
Name | BDBM1 | ||
Synonyms: | dT | thymidine | ||
Type | Nucleoside or nucleotide | ||
Emp. Form. | C10H14N2O5 | ||
Mol. Mass. | 242.2286 | ||
SMILES | Cc1cn([C@H]2C[C@H](O)[C@@H](CO)O2)c(=O)[nH]c1=O | ||
Structure | |||
BDBM2 | |||
Source: | Sigma | ||
Purity: | n/a | ||
Prep. Method: | n/a | ||
Name | BDBM2 | ||
Synonyms: | ({[({[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}(hydroxy)phosphoryl)oxy](hydroxy)phosphoryl}oxy)phosphonic acid | ATP | Brimonidine ATP | CHEMBL14249 | ||
Type | Nucleoside or nucleotide | ||
Emp. Form. | C10H16N5O13P3 | ||
Mol. Mass. | 507.181 | ||
SMILES | Nc1ncnc2n(cnc12)[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O |r| | ||
Structure |
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