Reaction Details | |||
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Cell Reactant: | BDBM14834 | ||
Syringe Reactant: | 5-hydroxytryptamine receptor 2A | ||
Meas. Tech.: | Isothermal Titration Calorimetry | ||
Entry Date: | 04/16/07 | ||
Δ G ° : | n/a | ||
pH: | 7±n/a | ||
Log10Kb: | 7.70± n/a | ||
Temperature: | 298.15±n/a (K) | ||
ΔH° : | n/a | ||
ΔHobs : | -47.7±0.836 (kJ/mole) | ||
Ionic Strength: | n/a | ||
no | |||
Protons Released: | n/a | ||
ΔCp : | n/a | ||
Stoich. Param.: | n/a | ||
ΔS° : | n/a | ||
Comments: | n/a | ||
Citation | Kroe, RR; Regan, J; Proto, A; Peet, GW; Roy, T; Landro, LD; Fuschetto, NG; Pargellis, CA; Ingraham, RH Thermal denaturation: a method to rank slow binding, high-affinity P38alpha MAP kinase inhibitors. J Med Chem46:4669-75 (2003) [PubMed] Article | ||
More Info.: | Get all data from this article , ITC RUN data , Solution Info , Data Fit Method , Instrument Info | ||
BDBM14834 | |||
Source: | n/a | ||
Purity: | n/a | ||
Prep. Method: | n/a | ||
Name | BDBM14834 | ||
Synonyms: | 1-[5-(2-Hydroxy-1,1-dimethylethyl)-2-p-tolyl-2H-pyrazol-3-yl]-3-[4-(2-morpholin-4-yl-ethoxy)-naphthalen-1-yl]-urea | 3-[3-(1-hydroxy-2-methylpropan-2-yl)-1-(4-methylphenyl)-1H-pyrazol-5-yl]-1-{4-[2-(morpholin-4-yl)ethoxy]naphthalen-1-yl}urea | BIRB-796 Analog 11 | CHEMBL107850 | Dopamine D2 receptor and serotonin 2a receptor | diaryl urea compound 3 | ||
Type | Small organic molecule | ||
Emp. Form. | C31H37N5O4 | ||
Mol. Mass. | 543.6566 | ||
SMILES | Cc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(OCCN2CCOCC2)c2ccccc12)C(C)(C)CO | ||
Structure | |||
5-hydroxytryptamine receptor 2A | |||
Source: | The full-length open reading frame of murine p38 alpha was cloned and expressed in E. coli. | ||
Purity: | n/a | ||
Prep. Method: | Soluble murine p38R was extracted from cell pellets and purified by using ion-exchange chromatography. Column fractions were concentrated, analyzed by SDS-PAGE, and pooled based on purity. | ||
Name: | 5-hydroxytryptamine receptor 2A | ||
Synonyms: | 5-HT-2 | 5-HT-2A | 5-HT2A | 5-hydroxytryptamine receptor 2A (5-HT-2A) | 5-hydroxytryptamine receptor 2A (5HT-2A) | 5-hydroxytryptamine receptor 2A (5HT2A) | 5HT2A_HUMAN | HTR2 | HTR2A | Serotonin receptor 2A | ||
Type: | undefined | ||
Mol. Mass.: | 52607.65 | ||
Organism: | Homo sapiens (Human) | ||
Description: | P28223 | ||
Residue: | 471 | ||
Sequence: |
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