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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Cell Reactant: | BDBM14835 | ||
| Syringe Reactant: | 5-hydroxytryptamine receptor 2A | ||
| Meas. Tech.: | Isothermal Titration Calorimetry | ||
| Entry Date: | 04/16/07 | ||
| Δ G ° : | n/a | ||
| pH: | 7±n/a | ||
| Log10Kb: | 8± n/a | ||
| Temperature: | 298.15±n/a (K) | ||
| ΔH° : | n/a | ||
| ΔHobs : | -42.2±2.09 (kJ/mole) | ||
| Ionic Strength: | n/a | ||
| no | |||
| Protons Released: | n/a | ||
| ΔCp : | n/a | ||
| Stoich. Param.: | n/a | ||
| ΔS° : | n/a | ||
| Comments: | n/a | ||
| Citation |  Kroe, RR; Regan, J; Proto, A; Peet, GW; Roy, T; Landro, LD; Fuschetto, NG; Pargellis, CA; Ingraham, RH Thermal denaturation: a method to rank slow binding, high-affinity P38alpha MAP kinase inhibitors. J Med Chem46:4669-75 (2003) [PubMed] Article | ||
| More Info.: | Get all data from this article , ITC RUN data , Solution Info , Data Fit Method , Instrument Info | ||
| BDBM14835 | |||
| Source: | n/a | ||
| Purity: | n/a | ||
| Prep. Method: | n/a | ||
| Name | BDBM14835 | ||
| Synonyms: | 1-(5-tert-Butyl-2-methyl-2H-pyrazol-3-yl)-3-[4-(2-morpholin-4-yl-ethoxy)-naphthalen-1-yl]-urea | 3-(3-tert-butyl-1-methyl-1H-pyrazol-5-yl)-1-{4-[2-(morpholin-4-yl)ethoxy]naphthalen-1-yl}urea | BIRB-796 Analog 35 | CHEMBL104749 | Dopamine D2 receptor and serotonin 2a receptor | diaryl urea compound 4 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C25H33N5O3 | ||
| Mol. Mass. | 451.5612 | ||
| SMILES | Cn1nc(cc1NC(=O)Nc1ccc(OCCN2CCOCC2)c2ccccc12)C(C)(C)C | ||
| Structure | 
| ||
| 5-hydroxytryptamine receptor 2A | |||
| Source: | The full-length open reading frame of murine p38 alpha was cloned and expressed in E. coli. | ||
| Purity: | n/a | ||
| Prep. Method: | Soluble murine p38R was extracted from cell pellets and purified by using ion-exchange chromatography. Column fractions were concentrated, analyzed by SDS-PAGE, and pooled based on purity. | ||
| Name: | 5-hydroxytryptamine receptor 2A | ||
| Synonyms: | 5-HT-2 | 5-HT-2A | 5-HT2A | 5-hydroxytryptamine receptor 2A (5-HT-2A) | 5-hydroxytryptamine receptor 2A (5HT-2A) | 5-hydroxytryptamine receptor 2A (5HT2A) | 5HT2A_HUMAN | HTR2 | HTR2A | Serotonin receptor 2A | ||
| Type: | undefined | ||
| Mol. Mass.: | 52607.65 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P28223 | ||
| Residue: | 471 | ||
| Sequence: |
| ||
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