Reaction Details | |||
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Cell Reactant: | H1/H5-depleted chromatin | ||
Syringe Reactant: | BDBM17 | ||
Meas. Tech.: | ITC | ||
Entry Date: | 12/11/00 | ||
ΔG°: | -6.63±0.0300 (kcal/mole) | ||
pH: | 7.5±n/a | ||
Log10Kb: | 4.92± 3.53 | ||
Temperature: | 293.15±n/a (K) | ||
ΔH° : | -10.3± (kcal/mole) | ||
ΔHobs : | -10.3± (kcal/mole) | ||
Ionic Strength: | n/a | ||
n/a | |||
Protons Released: | n/a | ||
ΔCp : | n/a | ||
Stoich. Param.: | n/a | ||
ΔS° : | -0.0100±0 (kcal/mole-K) | ||
Comments: | n/a | ||
Citation | Taquet, A; Labarbe, R; Houssier, C Calorimetric investigation of ethidium and netropsin binding to chicken erythrocyte chromatin. Biochemistry37:9119-26 (1998) [PubMed] Article | ||
More Info.: | Get all data from this article , ITC RUN data , Solution Info , Instrument Info | ||
H1/H5-depleted chromatin | |||
Source: | Obtained from freshly killed chicken | ||
Purity: | n/a | ||
Prep. Method: | nuclei were lysed and dialyzed against buffer, soluble chromatin were collected by centrifugation.H1 and H5 histones were depleted by adding NaCl 4M to chromatin solution up to 650 mM | ||
Name: | H1/H5-depleted chromatin | ||
Synonyms: | n/a | ||
Type: | Other | ||
Mol. Mass.: | n/a | ||
Description: | H1/H5 were depleted from chicken erythrocyte chromatin | ||
Components: | This complex has 0 components. | ||
Component 1 | |||
Name: | Histone deacetylase 1 | ||
Synonyms: | Cereblon/Histone deacetylase 1 | HD1 | HDAC1 | HDAC1_HUMAN | Histone deacetylase 1 (HDAC1) | Human HDAC1 | RPD3L1 | ||
Type: | Enzyme | ||
Mol. Mass.: | 55090.27 | ||
Organism: | Homo sapiens (Human) | ||
Description: | Q13547 | ||
Residue: | 482 | ||
Sequence: |
| ||
Component 2 | |||
Name: | Histone deacetylase 4 | ||
Synonyms: | Cereblon/Histone deacetylase 4 | HD4 | HDAC4 | HDAC4_HUMAN | Histone acetylase 4(HDAC4) | Human HDAC4 | KIAA0288 | ||
Type: | Enzyme | ||
Mol. Mass.: | 119049.39 | ||
Organism: | Homo sapiens (Human) | ||
Description: | P56524 | ||
Residue: | 1084 | ||
Sequence: |
| ||
BDBM17 | |||
Source: | Serva(heidelberg, Germany) | ||
Purity: | n/a | ||
Prep. Method: | n/a | ||
Name | BDBM17 | ||
Synonyms: | 4-(2-carbamimidamidoacetamido)-N-{5-[(2-carbamimidoylethyl)carbamoyl]-1-methyl-1H-pyrrol-3-yl}-1-methyl-1H-pyrrole-2-carboxamide | netropsin | ||
Type | Small organic molecule | ||
Emp. Form. | C18H26N10O3 | ||
Mol. Mass. | 430.4642 | ||
SMILES | Cn1cc(NC(=O)c2cc(NC(=O)CNC(N)=N)cn2C)cc1C(=O)NCCC(N)=N | ||
Structure |
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