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Cell Reactant:HIV-1 Nef
Syringe Reactant:BDBM22591
Meas. Tech.:Isothermal Titration Calorimetry
Entry Date:06/14/08
 
ΔG°:-29.3± (kJ/mole)
pH:7±n/a
Log10Kb:5.17± 4.70
Temperature:298.15±n/a (K)
ΔH° :n/a
ΔHobs :-6.40±0.850 (kJ/mole)
Ionic Strength:n/a
Corrected for ΔHioniz:no
Protons Released:n/a
ΔCp :n/a
Stoich. Param.:1.4
ΔS° : 0.0768± (kJ/mole-K)
Comments:n/a
 
Citation Betzi, SRestouin, AOpi, SArold, STParrot, IGuerlesquin, FMorelli, XCollette, Y Protein protein interaction inhibition (2P2I) combining high throughput and virtual screening: Application to the HIV-1 Nef protein. Proc Natl Acad Sci USA104:19256-61 (2007) [PubMed]  Article
More Info.:  Get all data from this article ,  ITC RUN data ,  Solution Info ,  Data Fit Method ,  Instrument Info
 
HIV-1 Nef
Source:The HIV-1 Nef core domain (residues 57-205) was expressed in Escherichia coli as glutathione S-transferase fusion proteins.
Purity:n/a
Prep. Method:n/a
Name:HIV-1 Nef
Synonyms:3ORF | F-protein | Nef | Negative factor | Protein Nef
Type:C-terminal core protein
Mol. Mass.:23340.47
Organism:Human immunodeficiency virus type 1 (isolate BRU/LAI group M subtype B)
Description:P03406
Residue:206
Sequence:
MGGKWSKSSVVGWPTVRERMRRAEPAADGVGAASRDLEKHGAITSSNTAATNAACAWLEA
QEEEEVGFPVTPQVPLRPMTYKAAVDLSHFLKEKGGLEGLIHSQRRQDILDLWIYHTQGY
FPDWQNYTPGPGVRYPLTFGWCYKLVPVEPDKVEEANKGENTSLLHPVSLHGMDDPEREV
LEWRFDSRLAFHHVARELHPEYFKNC
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM22591
Source:n/a
Purity:n/a
Prep. Method:n/a
NameBDBM22591
Synonyms:4-(phenanthren-3-yl)butanoic acid | 4-phenanthren-3-ylbutanoic acid | Compound D11
TypeSmall organic molecule
Emp. Form.C18H16O2
Mol. Mass.264.3184
SMILESOC(=O)CCCc1ccc2ccc3ccccc3c2c1
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least:

   
    

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Last update November 1, 2007
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