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Cell Reactant:HIV-1 Nef
Syringe Reactant:BDBM22593
Meas. Tech.:Isothermal Titration Calorimetry
Entry Date:06/14/08
 
ΔG°:-32.8± (kJ/mole)
pH:7±n/a
Log10Kb:5.74± 5.42
Temperature:298.15±n/a (K)
ΔH° :n/a
ΔHobs :-4±0.400 (kJ/mole)
Ionic Strength:n/a
Corrected for ΔHioniz:no
Protons Released:n/a
ΔCp :n/a
Stoich. Param.:0.83
ΔS° : 0.0966± (kJ/mole-K)
Comments:n/a
 
Citation Betzi, SRestouin, AOpi, SArold, STParrot, IGuerlesquin, FMorelli, XCollette, Y Protein protein interaction inhibition (2P2I) combining high throughput and virtual screening: Application to the HIV-1 Nef protein. Proc Natl Acad Sci USA104:19256-61 (2007) [PubMed]  Article
More Info.:  Get all data from this article ,  ITC RUN data ,  Solution Info ,  Data Fit Method ,  Instrument Info
 
HIV-1 Nef
Source:The HIV-1 Nef core domain (residues 57-205) was expressed in Escherichia coli as glutathione S-transferase fusion proteins.
Purity:n/a
Prep. Method:n/a
Name:HIV-1 Nef
Synonyms:3ORF | F-protein | Nef | Negative factor | Protein Nef
Type:C-terminal core protein
Mol. Mass.:23340.47
Organism:Human immunodeficiency virus type 1 (isolate BRU/LAI group M subtype B)
Description:P03406
Residue:206
Sequence:
MGGKWSKSSVVGWPTVRERMRRAEPAADGVGAASRDLEKHGAITSSNTAATNAACAWLEA
QEEEEVGFPVTPQVPLRPMTYKAAVDLSHFLKEKGGLEGLIHSQRRQDILDLWIYHTQGY
FPDWQNYTPGPGVRYPLTFGWCYKLVPVEPDKVEEANKGENTSLLHPVSLHGMDDPEREV
LEWRFDSRLAFHHVARELHPEYFKNC
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM22593
Source:n/a
Purity:n/a
Prep. Method:n/a
NameBDBM22593
Synonyms:5-[(4-tert-butylphenoxycarbonyl)amino]-2-hydroxybenzoic acid | Compound D14
TypeSmall organic molecule
Emp. Form.C18H19NO5
Mol. Mass.329.3472
SMILESCC(C)(C)c1ccc(OC(=O)Nc2ccc(O)c(c2)C(O)=O)cc1
Structure
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Last update November 1, 2007
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