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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Cell Reactant: | HIV-1 Nef | ||
| Syringe Reactant: | BDBM22595 | ||
| Meas. Tech.: | Isothermal Titration Calorimetry | ||
| Entry Date: | 06/14/08 | ||
| ΔG°: | -8.18± (kcal/mole) | ||
| pH: | 7±n/a | ||
| Log10Kb: | 6.01± 5.49 | ||
| Temperature: | 298.15±n/a (K) | ||
| ΔH° : | n/a | ||
| ΔHobs : | -0.770±0.0500 (kcal/mole) | ||
| Ionic Strength: | n/a | ||
| no | |||
| Protons Released: | n/a | ||
| ΔCp : | n/a | ||
| Stoich. Param.: | 1.14 | ||
| ΔS° : | 0.0200± (kcal/mole-K) | ||
| Comments: | n/a | ||
| Citation |  Betzi, S; Restouin, A; Opi, S; Arold, ST; Parrot, I; Guerlesquin, F; Morelli, X; Collette, Y Protein protein interaction inhibition (2P2I) combining high throughput and virtual screening: Application to the HIV-1 Nef protein. Proc Natl Acad Sci U S A104:19256-61 (2007) [PubMed] Article | ||
| More Info.: | Get all data from this article , ITC RUN data , Solution Info , Data Fit Method , Instrument Info | ||
| HIV-1 Nef | |||
| Source: | The HIV-1 Nef core domain (residues 57-205) was expressed in Escherichia coli as glutathione S-transferase fusion proteins. | ||
| Purity: | n/a | ||
| Prep. Method: | n/a | ||
| Name: | Protein Nef | ||
| Synonyms: | 3ORF | F-protein | HIV-1 Nef | NEF_HV1BR | Negative factor | Protein Nef | nef | ||
| Type: | C-terminal core protein | ||
| Mol. Mass.: | 23340.47 | ||
| Organism: | Human immunodeficiency virus type 1 (isolate BRU/LAI group M subtype B) | ||
| Description: | P03406 | ||
| Residue: | 206 | ||
| Sequence: |
| ||
| BDBM22595 | |||
| Source: | n/a | ||
| Purity: | n/a | ||
| Prep. Method: | n/a | ||
| Name | BDBM22595 | ||
| Synonyms: | 3-[2-(4-tert-butylphenoxy)acetamido]benzoic acid | Compound DLC27 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C19H21NO4 | ||
| Mol. Mass. | 327.3743 | ||
| SMILES | CC(C)(C)c1ccc(OCC(=O)Nc2cccc(c2)C(O)=O)cc1 | ||
| Structure | 
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