Reaction Details | |||
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Cell Reactant: | DNA Gyrase | ||
Syringe Reactant: | BDBM285 | ||
Meas. Tech.: | Isothermal Titration Calorimetry | ||
Entry Date: | 03/31/03 | ||
ΔG°: | -35.1±0.200 (kJ/mole) | ||
pH: | 7.5±n/a | ||
Log10Kb: | 6.15± 5 | ||
Temperature: | 298.15±n/a (K) | ||
ΔH° : | -18±0.5 (kJ/mole) | ||
ΔHobs : | -18±0.5 (kJ/mole) | ||
Ionic Strength: | n/a | ||
not known | |||
Protons Released: | n/a | ||
ΔCp : | -0.62±0.06 (kJ/mole) | ||
Stoich. Param.: | n/a | ||
ΔS° : | 0.0574±0.00100 (kJ/mole-K) | ||
Comments: | n/a | ||
Citation | Lafitte, D; Lamour, V; Tsvetkov, PO; Makarov, AA; Klich, M; Deprez, P; Moras, D; Briand, C; Gilli, R DNA gyrase interaction with coumarin-based inhibitors: the role of the hydroxybenzoate isopentenyl moiety and the 5'-methyl group of the noviose. Biochemistry41:7217-23 (2002) [PubMed] Article | ||
More Info.: | Get all data from this article , ITC RUN data , Solution Info , Data Fit Method , Instrument Info | ||
DNA Gyrase | |||
Source: | Bacterial clone | ||
Purity: | 97% | ||
Prep. Method: | Gilbert, E. J., and Maxwell, A. (1994) Mol. Microbiol. 12, 365-373. | ||
Name: | DNA gyrase subunit B | ||
Synonyms: | gyrB | ||
Type: | Enzyme | ||
Mol. Mass.: | 89941.28 | ||
Organism: | Escherichia coli | ||
Description: | C3SLN3 | ||
Residue: | 804 | ||
Sequence: |
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BDBM285 | |||
Source: | Synthesis | ||
Purity: | n/a | ||
Prep. Method: | Ferroud, D., Collard, J., Klich, M., Dupuis-Hamelin, C., Mauvais, P., Lassaigne, P., Bonnefoy, A., and Musicki, B.(1999) Bioorg. Med. Chem. Lett. 9, 2881-2886. | ||
Name | BDBM285 | ||
Synonyms: | Coumarin-Based, DNA Gyrase Inhibitor | RU 64136 | {[7-({3-hydroxy-5-methoxy-6-methyl-4-[(5-methyl-1H-pyrrol-2-yl)carbonyloxy]oxan-2-yl}oxy)-8-methyl-2-oxo-2H-chromen-4-yl]methyl}phosphonate | ||
Type | Antibiotic | ||
Emp. Form. | C24H26NO11P | ||
Mol. Mass. | 535.4382 | ||
SMILES | COC1C(C)OC(Oc2ccc3c(CP([O-])([O-])=O)cc(=O)oc3c2C)C(O)C1OC(=O)c1ccc(C)[nH]1 | ||
Structure |
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