Reaction Details | |||
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Cell Reactant: | Heat Shock Protein 90 (Hsp90) | ||
Syringe Reactant: | BDBM15359 | ||
Meas. Tech.: | Isothermal Titration Calorimetry | ||
Entry Date: | 09/29/09 | ||
ΔG°: | -7.68± (kcal/mole) | ||
pH: | 8±n/a | ||
Log10Kb: | 5.73± 4.60 | ||
Temperature: | 293.15±n/a (K) | ||
ΔH° : | n/a | ||
ΔHobs : | -6.51±0.140 (kcal/mole) | ||
Ionic Strength: | n/a | ||
no | |||
Protons Released: | n/a | ||
ΔCp : | n/a | ||
Stoich. Param.: | n/a | ||
ΔS° : | 0± (kcal/mole-K) | ||
Comments: | n/a | ||
Citation | Nilapwar, S; Williams, E; Fu, C; Prodromou, C; Pearl, LH; Williams, MA; Ladbury, JE Structural-thermodynamic relationships of interactions in the N-terminal ATP-binding domain of Hsp90. J Mol Biol392:923-36 (2009) [PubMed] Article | ||
More Info.: | Get all data from this article , ITC RUN data , Solution Info , Data Fit Method , Instrument Info | ||
Heat Shock Protein 90 (Hsp90) | |||
Source: | His-tagged N-terminal domain of yeast HSP90 was expressed and purified. | ||
Purity: | n/a | ||
Prep. Method: | Protein was purified by using nickel affinity column, and was subsequently concentrated by an (NH4)2SO4 precipitation and purified further using gel filtration chromatography. | ||
Name: | Heat Shock Protein 90 (Hsp90) | ||
Synonyms: | 82 kDa heat shock protein | ATP-dependent molecular chaperone HSP82 | HSP82 | HSP82_YEAST | HSP90 | Heat shock protein Hsp90 heat-inducible isoform | ||
Type: | N-terminal domain | ||
Mol. Mass.: | 23389.88 | ||
Organism: | Saccharomyces cerevisiae (Baker s yeast) | ||
Description: | P02829 aa 1-207 | ||
Residue: | 207 | ||
Sequence: |
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BDBM15359 | |||
Source: | n/a | ||
Purity: | n/a | ||
Prep. Method: | n/a | ||
Name | BDBM15359 | ||
Synonyms: | (4E,6Z,8S,9S,10E,12S,13R,14S,16R)-13-hydroxy-8,14-dimethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-19-(prop-2-en-1-ylamino)-2-azabicyclo[16.3.1]docosa-1(21),4,6,10,18-pentaen-9-yl carbamate | 17-(Allylamino)geldanamycin | 17-AAG | 17AAG | CHEMBL109480 | GLD-36 | Tanespimycin | ||
Type | Small organic molecule | ||
Emp. Form. | C31H43N3O8 | ||
Mol. Mass. | 585.6884 | ||
SMILES | CO[C@H]1C[C@H](C)Cc2c(O)c(NC(=O)C(C)=CC=C[C@H](OC)[C@@H](OC(N)=O)\C(C)=C\[C@H](C)[C@H]1O)cc(O)c2N=CC=C |r,w:16.16,38.39,t:28| | ||
Structure |
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