Reaction Details | |||
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Cell Reactant: | Heat Shock Protein 90 (Hsp90) | ||
Syringe Reactant: | BDBM18134 | ||
Meas. Tech.: | Isothermal Titration Calorimetry | ||
Entry Date: | 09/29/09 | ||
ΔG°: | -5.31± (kcal/mole) | ||
pH: | 8±n/a | ||
Log10Kb: | 3.89± 2.60 | ||
Temperature: | 298.15±n/a (K) | ||
ΔH° : | n/a | ||
ΔHobs : | -7.99±0.260 (kcal/mole) | ||
Ionic Strength: | n/a | ||
no | |||
Protons Released: | n/a | ||
ΔCp : | n/a | ||
Stoich. Param.: | n/a | ||
ΔS° : | -0.0100± (kcal/mole-K) | ||
Comments: | n/a | ||
Citation | Nilapwar, S; Williams, E; Fu, C; Prodromou, C; Pearl, LH; Williams, MA; Ladbury, JE Structural-thermodynamic relationships of interactions in the N-terminal ATP-binding domain of Hsp90. J Mol Biol392:923-36 (2009) [PubMed] Article | ||
More Info.: | Get all data from this article , ITC RUN data , Solution Info , Data Fit Method , Instrument Info | ||
Heat Shock Protein 90 (Hsp90) | |||
Source: | His-tagged N-terminal domain of yeast HSP90 was expressed and purified. | ||
Purity: | n/a | ||
Prep. Method: | Protein was purified by using nickel affinity column, and was subsequently concentrated by an (NH4)2SO4 precipitation and purified further using gel filtration chromatography. | ||
Name: | Heat Shock Protein 90 (Hsp90) | ||
Synonyms: | 82 kDa heat shock protein | ATP-dependent molecular chaperone HSP82 | HSP82 | HSP82_YEAST | HSP90 | Heat shock protein Hsp90 heat-inducible isoform | ||
Type: | N-terminal domain | ||
Mol. Mass.: | 23389.88 | ||
Organism: | Saccharomyces cerevisiae (Baker s yeast) | ||
Description: | P02829 aa 1-207 | ||
Residue: | 207 | ||
Sequence: |
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BDBM18134 | |||
Source: | n/a | ||
Purity: | n/a | ||
Prep. Method: | n/a | ||
Name | BDBM18134 | ||
Synonyms: | ({[({[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}(hydroxy)phosphoryl)oxy](hydroxy)phosphoryl}amino)phosphonic acid | 5-Adenylyl imidodiphosphate | AMP.P[NH]P | AMPPNP | ||
Type | Nucleoside or nucleotide | ||
Emp. Form. | C10H17N6O12P3 | ||
Mol. Mass. | 506.1963 | ||
SMILES | Nc1ncnc2n(cnc12)[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)NP(O)(O)=O)[C@@H](O)[C@H]1O |r| | ||
Structure |
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