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Cell Reactant:Heat Shock Protein 90 (Hsp90)
Syringe Reactant:BDBM31995
Meas. Tech.:Isothermal Titration Calorimetry
Entry Date:09/29/09
 
ΔG°:-6.46± (kcal/mole)
pH:8±n/a
Log10Kb:4.95± 3.90
Temperature:283.15±n/a (K)
ΔH° :n/a
ΔHobs :-17.4±0.690 (kcal/mole)
Ionic Strength:n/a
Corrected for ΔHioniz:no
Protons Released:n/a
ΔCp :n/a
Stoich. Param.:n/a
ΔS° :-0.0400± (kcal/mole-K)
Comments:n/a
 
Citation Nilapwar SWilliams EFu CProdromou CPearl LHWilliams MALadbury JE Structural-thermodynamic relationships of interactions in the N-terminal ATP-binding domain of Hsp90. J Mol Biol 392:923-36 (2009) [PubMed]  Article
More Info.:  Get all data from this article ,  ITC RUN data ,  Solution Info ,  Data Fit Method ,  Instrument Info
 
Heat Shock Protein 90 (Hsp90)
Source:His-tagged N-terminal domain of yeast HSP90 was expressed and purified.
Purity:n/a
Prep. Method:Protein was purified by using nickel affinity column, and was subsequently concentrated by an (NH4)2SO4 precipitation and purified further using gel filtration chromatography.
Name:Heat Shock Protein 90 (Hsp90)
Synonyms:82 kDa heat shock protein | ATP-dependent molecular chaperone HSP82 | Heat shock protein Hsp90 heat-inducible isoform
Type:N-terminal domain
Mol. Mass.:23389.88
Organism:Saccharomyces cerevisiae (Baker s yeast)
Description:n/a
Residue:207
Sequence:
MASETFEFQAEITQLMSLIINTVYSNKEIFLRELISNASDALDKIRYKSLSDPKQLETEP
DLFIRITPKPEQKVLEIRDSGIGMTKAELINNLGTIAKSGTKAFMEALSAGADVSMIGQF
GVGFYSLFLVADRVQVISKSNDDEQYIWESNAGGSFTVTLDEVNERIGRGTILRLFLKDD
QLEYLEEKRIKEVIKRHSEFVAYPIQL
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM31995
Source:n/a
Purity:n/a
Prep. Method:n/a
NameBDBM31995
Synonyms:ADP | Adenosine Diphosphate (ADP) | CHEMBL14830
TypeNucleoside or nucleotide
Emp. Form.C10H15N5O10P2
Mol. Mass.427.2011
SMILESNc1ncnc2n(cnc12)[C@@H]1O[C@H](COP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O
Structure
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Last update November 1, 2007
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