Reaction Details | |||
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Report a problem with these data | |||
Cell Reactant: | Trypsin | ||
Syringe Reactant: | BDBM773 | ||
Meas. Tech.: | Isothermal Titration Calorimetry | ||
Entry Date: | 06/15/04 | ||
ΔG°: | -6.60±0.0200 (kcal/mole) | ||
pH: | 8±n/a | ||
Log10Kb: | 4.84± 3.48 | ||
Temperature: | 298.25±n/a (K) | ||
ΔH° : | -4.43±0.0700 (kcal/mole) | ||
ΔHobs : | -4.43±0.0700 (kcal/mole) | ||
Ionic Strength: | n/a | ||
not known | |||
Protons Released: | n/a | ||
ΔCp : | n/a | ||
Stoich. Param.: | n/a | ||
ΔS° : | 0.0100±0 (kcal/mole-K) | ||
Comments: | Data taken from Talhout, R.; Engberts, J. B. F. N. Eur. J. Biochem. 2001, 268, 1554-1560. | ||
Citation | Talhout, R; Villa, A; Mark, AE; Engberts, JB Understanding binding affinity: a combined isothermal titration calorimetry/molecular dynamics study of the binding of a series of hydrophobically modified benzamidinium chloride inhibitors to trypsin. J Am Chem Soc125:10570-9 (2003) [PubMed] Article | ||
More Info.: | Get all data from this article , ITC RUN data , Solution Info , Data Fit Method , Instrument Info | ||
Trypsin | |||
Source: | no | ||
Purity: | n/a | ||
Prep. Method: | n/a | ||
Name: | Serine protease 1 | ||
Synonyms: | Beta-Trypsin | Cationic trypsin | PRSS1 | TRP1 | TRY1 | TRY1_BOVIN | TRYP1 | Trypsin | Trypsin I | ||
Type: | Enzyme | ||
Mol. Mass.: | 25790.52 | ||
Organism: | Bos taurus (bovine) | ||
Description: | P00760 | ||
Residue: | 246 | ||
Sequence: |
| ||
BDBM773 | |||
Source: | Synthesized | ||
Purity: | n/a | ||
Prep. Method: | n/a | ||
Name | BDBM773 | ||
Synonyms: | [amino(4-methylphenyl)methylidene]azanium | benzamidine deriv. | p-methylbenzamidinium chloride | ||
Type | Small organic molecule | ||
Emp. Form. | C8H11N2 | ||
Mol. Mass. | 135.1858 | ||
SMILES | Cc1ccc(cc1)C(N)=[NH2+] | ||
Structure |
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