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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Cell Reactant: | Purine nucleoside phosphorylase | ||
| Syringe Reactant: | BDBM50252909 | ||
| Meas. Tech.: | Enzyme Inhibition | ||
| Entry Date: | 03/18/13 | ||
| ΔG°: | -12.0±0.0500 (kcal/mole) | ||
| pH: | 7.4±0 | ||
| Log10Kb: | 8.80± n/a | ||
| Temperature: | 298.15±0 (K) | ||
| ΔH° : | n/a | ||
| ΔHobs: | n/a | ||
| Ionic Strength: | n/a | ||
| n/a | |||
| Protons Released: | n/a | ||
| ΔCp : | n/a | ||
| Stoich. Param.: | n/a | ||
| ΔS° : | n/a | ||
| Comments: | n/a | ||
| Citation |  Edwards, AA; Mason, JM; Clinch, K; Tyler, PC; Evans, GB; Schramm, VL Altered enthalpy-entropy compensation in picomolar transition state analogues of human purine nucleoside phosphorylase. Biochemistry48:5226-38 (2009) [PubMed] Article | ||
| More Info.: | Get all data from this article , ITC RUN data | ||
| Purine nucleoside phosphorylase | |||
| Source: | n/a | ||
| Purity: | n/a | ||
| Prep. Method: | n/a | ||
| Name: | Purine nucleoside phosphorylase | ||
| Synonyms: | Inosine phosphorylase | Inosine-guanosine phosphorylase | NP | PNP | PNPH_HUMAN | Purine nucleoside phosphorylase (PNPase) | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 32119.53 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | n/a | ||
| Residue: | 289 | ||
| Sequence: |
| ||
| BDBM50252909 | |||
| Source: | n/a | ||
| Purity: | n/a | ||
| Prep. Method: | n/a | ||
| Name | BDBM50252909 | ||
| Synonyms: | (3R,4R)-1-((9-Deazahypoxanthin-9-yl)methyl)-4-fluoro-4-hydroxymethyl pyrrolidin-3-ol | CHEMBL522870 | Immucillins, 5 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C12H15FN4O3 | ||
| Mol. Mass. | 282.2709 | ||
| SMILES | OC[C@]1(F)CN(Cc2c[nH]c3c2nc[nH]c3=O)C[C@H]1O |r| | ||
| Structure | 
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