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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Cell Reactant: | MAP kinase ERK1 | ||
| Syringe Reactant: | BDBM103302 | ||
| Meas. Tech.: | Enzyme Inhibition | ||
| Entry Date: | 10/22/14 | ||
| ΔG°: | -36.8± (kJ/mole) | ||
| pH: | 7.5±0 | ||
| Log10Kb: | 6.66± n/a | ||
| Temperature: | 288.15±0 (K) | ||
| ΔH° : | -86.2±0.800 (kJ/mole) | ||
| ΔHobs: | n/a | ||
| Ionic Strength: | n/a | ||
| n/a | |||
| Protons Released: | n/a | ||
| ΔCp : | n/a | ||
| Stoich. Param.: | n/a | ||
| ΔS° : | -0.1716±0 (kJ/mole-K) | ||
| Comments: | n/a | ||
| Citation |  Chaikuad, A; Tacconi, EM; Zimmer, J; Liang, Y; Gray, NS; Tarsounas, M; Knapp, S A unique inhibitor binding site in ER K1/2 is associated with slow binding kinetics Nat Chem Biol10:853-860 (2014) [PubMed] Article | ||
| More Info.: | Get all data from this article , ITC RUN data | ||
| MAP kinase ERK1 | |||
| Source: | n/a | ||
| Purity: | n/a | ||
| Prep. Method: | n/a | ||
| Name: | Mitogen-activated protein kinase 3 | ||
| Synonyms: | ERK1 | ERK1/ERK2 | Extracellular signal-regulated kinase 1 | Extracellular signal-regulated kinase 1 (ERK1) | MAP kinase ERK1 | MAPK3 | MAPK3/MAPK7 | MK03_HUMAN | Mitogen-activated protein kinase | Mitogen-activated protein kinase 3 | PRKM3 | ||
| Type: | Protein | ||
| Mol. Mass.: | 43136.58 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | curated by PDB 4QTB | ||
| Residue: | 379 | ||
| Sequence: |
| ||
| BDBM103302 | |||
| Source: | n/a | ||
| Purity: | n/a | ||
| Prep. Method: | n/a | ||
| Name | BDBM103302 | ||
| Synonyms: | SCH772984 | US8546404, 6 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C33H33N9O2 | ||
| Mol. Mass. | 587.6742 | ||
| SMILES | O=C(CN1CC[C@@H](C1)C(=O)Nc1ccc2[nH]nc(-c3ccncc3)c2c1)N1CCN(CC1)c1ccc(cc1)-c1ncccn1 |r| | ||
| Structure | 
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