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Cell Reactant:Histone deacetylase 8 (HDAC8)
Syringe Reactant:BDBM152690
Meas. Tech.:Enzyme Inhibition
Entry Date:09/14/15
 
ΔG°:-8.61±0.190 (kcal/mole)
pH:7.5±0
Log10Kb:6.53± n/a
Temperature:25±0 (K)
ΔH° :-11.7± (kcal/mole)
ΔHobs :-5.5±0.480 (kcal/mole)
Ionic Strength:n/a
Corrected for ΔHioniz:n/a
Protons Released:n/a
ΔCp :n/a
Stoich. Param.:n/a
ΔS° :-0.0100±0 (kcal/mole-K)
Comments:n/a
 
Citation Singh, RKSuzuki, TMandal, TBalsubramanian, NHaldar, MMueller, DJStrode, JACook, GMallik, SSrivastava, DK Thermodynamics of binding of structurally similar ligands to histone deacetylase 8 sheds light on challenges in the rational design of potent and isozyme-selective inhibitors of the enzyme. Biochemistry53:7445-58 (2014) [PubMed]  Article
More Info.:  Get all data from this article ,  ITC RUN data ,  Solution Info ,  Instrument Info
 
Histone deacetylase 8 (HDAC8)
Source:n/a
Purity:n/a
Prep. Method:n/a
Name:Histone deacetylase 8
Synonyms:HD8 | HDAC8 | HDAC8_HUMAN | HDACL1 | Histone deacetylase 8 (HDAC-8) | Human HDAC8
Type:Enzyme
Mol. Mass.:41749.60
Organism:Homo sapiens (Human)
Description:Q9BY41
Residue:377
Sequence:
MEEPEEPADSGQSLVPVYIYSPEYVSMCDSLAKIPKRASMVHSLIEAYALHKQMRIVKPK
VASMEEMATFHTDAYLQHLQKVSQEGDDDHPDSIEYGLGYDCPATEGIFDYAAAIGGATI
TAAQCLIDGMCKVAINWSGGWHHAKKDEASGFCYLNDAVLGILRLRRKFERILYVDLDLH
HGDGVEDAFSFTSKVMTVSLHKFSPGFFPGTGDVSDVGLGKGRYYSVNVPIQDGIQDEKY
YQICESVLKEVYQAFNPKAVVLQLGADTIAGDPMCSFNMTPVGIGKCLKYILQWQLATLI
LGGGGYNLANTARCWTYLTGVILGKTLSSEIPDHEFFTAYGPDYVLEITPSCRPDRNEPH
RIQQILNYIKGNLKHVV
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM152690
Source:n/a
Purity:n/a
Prep. Method:n/a
NameBDBM152690
Synonyms:C6-coumarinSAHA (C6-cSAHA)
TypeSmall organic molecule
Emp. Form.C18H22N2O5
Mol. Mass.346.3777
SMILESCc1cc(=O)oc2cc(NC(=O)CCCCCCC(=O)NO)ccc12
Structure
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