Reaction Details | |||
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Cell Reactant: | Histone deacetylase 8 (HDAC8) | ||
Syringe Reactant: | BDBM152690 | ||
Meas. Tech.: | Enzyme Inhibition | ||
Entry Date: | 09/14/15 | ||
ΔG°: | -8.61±0.190 (kcal/mole) | ||
pH: | 7.5±0 | ||
Log10Kb: | 6.53± n/a | ||
Temperature: | 25±0 (K) | ||
ΔH° : | -11.7± (kcal/mole) | ||
ΔHobs : | -5.5±0.480 (kcal/mole) | ||
Ionic Strength: | n/a | ||
n/a | |||
Protons Released: | n/a | ||
ΔCp : | n/a | ||
Stoich. Param.: | n/a | ||
ΔS° : | -0.0100±0 (kcal/mole-K) | ||
Comments: | n/a | ||
Citation | Singh, RK; Suzuki, T; Mandal, T; Balsubramanian, N; Haldar, M; Mueller, DJ; Strode, JA; Cook, G; Mallik, S; Srivastava, DK Thermodynamics of binding of structurally similar ligands to histone deacetylase 8 sheds light on challenges in the rational design of potent and isozyme-selective inhibitors of the enzyme. Biochemistry53:7445-58 (2014) [PubMed] Article | ||
More Info.: | Get all data from this article , ITC RUN data , Solution Info , Instrument Info | ||
Histone deacetylase 8 (HDAC8) | |||
Source: | n/a | ||
Purity: | n/a | ||
Prep. Method: | n/a | ||
Name: | Histone deacetylase 8 | ||
Synonyms: | HD8 | HDAC8 | HDAC8_HUMAN | HDACL1 | Histone deacetylase 8 (HDAC-8) | Human HDAC8 | ||
Type: | Enzyme | ||
Mol. Mass.: | 41749.60 | ||
Organism: | Homo sapiens (Human) | ||
Description: | Q9BY41 | ||
Residue: | 377 | ||
Sequence: |
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BDBM152690 | |||
Source: | n/a | ||
Purity: | n/a | ||
Prep. Method: | n/a | ||
Name | BDBM152690 | ||
Synonyms: | C6-coumarinSAHA (C6-cSAHA) | ||
Type | Small organic molecule | ||
Emp. Form. | C18H22N2O5 | ||
Mol. Mass. | 346.3777 | ||
SMILES | Cc1cc(=O)oc2cc(NC(=O)CCCCCCC(=O)NO)ccc12 | ||
Structure |
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