Reaction Details | |||
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Cell Reactant: | Ephrin type-A receptor 4 ligand binding domain (I59A-EphA4-LBD) | ||
Syringe Reactant: | BDBM223311 | ||
Meas. Tech.: | Enzyme Inhibition | ||
Entry Date: | 04/27/17 | ||
ΔG°: | -21.4± (kJ/mole) | ||
pH: | 6.5±0 | ||
Log10Kb: | 3.73± n/a | ||
Temperature: | 300.15±0 (K) | ||
ΔH° : | -14.4±1.70 (kJ/mole) | ||
ΔHobs: | n/a | ||
Ionic Strength: | n/a | ||
n/a | |||
Protons Released: | n/a | ||
ΔCp : | n/a | ||
Stoich. Param.: | n/a | ||
ΔS° : | 0.0234±0 (kJ/mole-K) | ||
Comments: | n/a | ||
Citation | Wu, B; De, SK; Kulinich, A; Salem, AF; Koeppen, J; Wang, R; Barile, E; Wang, S; Zhang, D; Ethell, I; Pellecchia, M Potent and Selective EphA4 Agonists for the Treatment of ALS. Cell Chem Biol24:293-305 (2017) [PubMed] Article | ||
More Info.: | Get all data from this article , ITC RUN data | ||
Ephrin type-A receptor 4 ligand binding domain (I59A-EphA4-LBD) | |||
Source: | n/a | ||
Purity: | n/a | ||
Prep. Method: | n/a | ||
Name: | Ephrin type-A receptor 4 [29-209,I59A] | ||
Synonyms: | EPHA4 | EPHA4_HUMAN | Ephrin type-A receptor 4 ligand binding domain (I59A-EphA4-LBD) | HEK8 | SEK | TYRO1 | ||
Type: | Protein | ||
Mol. Mass.: | 20808.36 | ||
Organism: | Homo sapiens (Human) | ||
Description: | Human EphA4-LBD I59A mutant | ||
Residue: | 181 | ||
Sequence: |
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BDBM223311 | |||
Source: | n/a | ||
Purity: | n/a | ||
Prep. Method: | n/a | ||
Name | BDBM223311 | ||
Synonyms: | 123C4 | ||
Type | Small organic molecule | ||
Emp. Form. | C43H47ClN8O6 | ||
Mol. Mass. | 807.336 | ||
SMILES | COc1ccc2[nH]cc(CCNC(=O)[C@H](Cc3ccncc3)NC(=O)[C@H](Cc3ccc(Cl)cc3)NC(=O)[C@H](Cc3c[nH]c4ccc(O)cc34)NC(=O)CCCN)c2c1 |r| | ||
Structure |
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