Reaction Details | |||
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Cell Reactant: | Reverse transcriptase (HIV-1 RT)(1-350) | ||
Syringe Reactant: | BDBM2483 | ||
Meas. Tech.: | Enzyme Inhibition | ||
Entry Date: | 06/16/17 | ||
ΔG°: | -158±47.7 (kJ/mole) | ||
pH: | n/a | ||
Log10Kb: | n/a | ||
Temperature: | 298.15±0 (K) | ||
ΔH° : | -240± (kJ/mole) | ||
ΔHobs: | n/a | ||
Ionic Strength: | n/a | ||
n/a | |||
Protons Released: | n/a | ||
ΔCp : | n/a | ||
Stoich. Param.: | n/a | ||
ΔS° : | -0.277±0.156 (kJ/mole-K) | ||
Comments: | n/a | ||
Citation | Decha, P; Intharathep, P; Udommaneethanakit, T; Sompornpisut, P; Hannongbua, S; Wolschann, P; Parasuk, V Theoretical studies on the molecular basis of HIV-1RT/NNRTIs interactions. J Enzyme Inhib Med Chem26:29-36 (2011) [PubMed] Article | ||
More Info.: | Get all data from this article , ITC RUN data | ||
Reverse transcriptase (HIV-1 RT)(1-350) | |||
Source: | n/a | ||
Purity: | n/a | ||
Prep. Method: | n/a | ||
Name: | Reverse transcriptase (HIV-1 RT)(aa 1-350) | ||
Synonyms: | POL_HV1H2 | gag-pol | ||
Type: | Enzyme | ||
Mol. Mass.: | 39217.95 | ||
Organism: | Human immunodeficiency virus type 1 | ||
Description: | HIV-1 RT variant (1-350 aa) | ||
Residue: | 350 | ||
Sequence: |
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BDBM2483 | |||
Source: | n/a | ||
Purity: | n/a | ||
Prep. Method: | n/a | ||
Name | BDBM2483 | ||
Synonyms: | (4S)-6-chloro-4-(2-cyclopropylethynyl)-4-(trifluoromethyl)-2,4-dihydro-1H-3,1-benzoxazin-2-one | CHEMBL223228 | DMP-266 | EFV | Efavirenz | Efavirenz (EFV) | L-743,726 | Sustiva | ||
Type | Small organic molecule | ||
Emp. Form. | C14H9ClF3NO2 | ||
Mol. Mass. | 315.675 | ||
SMILES | FC(F)(F)[C@]1(OC(=O)Nc2ccc(Cl)cc12)C#CC1CC1 |r| | ||
Structure |
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