Reaction Details |
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Target | Protein cereblon |
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Ligand | BDBM65362 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Thalidomide analog bead assay |
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IC50 | >300000±0 nM |
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Citation | Lopez-Girona, A; Mendy, D; Ito, T; Miller, K; Gandhi, AK; Kang, J; Karasawa, S; Carmel, G; Jackson, P; Abbasian, M; Mahmoudi, A; Cathers, B; Rychak, E; Gaidarova, S; Chen, R; Schafer, PH; Handa, H; Daniel, TO; Evans, JF; Chopra, R Cereblon is a direct protein target for immunomodulatory and antiproliferative activities of lenalidomide and pomalidomide. Leukemia26:2326-35 (2012) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Protein cereblon |
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Name: | Protein cereblon |
Synonyms: | CRBN | CRBN_HUMAN |
Type: | PROTEIN |
Mol. Mass.: | 50537.73 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_116917 |
Residue: | 442 |
Sequence: | MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYL
GADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTF
AVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQA
KVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSW
PRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLK
IGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETL
TVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRS
ALLPTIPDTEDEISPDKVILCL
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BDBM65362 |
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n/a |
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Name | BDBM65362 |
Synonyms: | (+)-Thalidomide | (R)-(+)-thalidomide | (R)-Thalidomide | D-Thalidomide |
Type | Small organic molecule |
Emp. Form. | C13H10N2O4 |
Mol. Mass. | 258.2295 |
SMILES | O=C1N([C@@H]2CCC(=O)NC2=O)C(=O)c2ccccc12 |
Structure |
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