Ki Summary

Reaction Details

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Target

cAMP-specific 3',5'-cyclic phosphodiesterase 4C

Ligand

BDBM285539

Substrate/Competitor

n/a

IC50

89.6±n/a nM

Citation

Chappie, TA; Verhoest, PR; Patel, NC; Hayward, MM; Helal, CJ; Sciabola, S; LaChapelle, EA; Young, JM Imidazopyridazine compounds US Patent US9598421 Publication Date 3/21/2017

More Info.:

Get all data from this article, Assay Method

cAMP-specific 3',5'-cyclic phosphodiesterase 4C

Name:

cAMP-specific 3',5'-cyclic phosphodiesterase 4C

Synonyms:

Type:

Enzyme Catalytic Domain

Mol. Mass.:

79875.54

Organism:

Homo sapiens (Human)

Description:

Q08493

Residue:

712

Sequence:

MENLGVGEGAEACSRLSRSRGRHSMTRAPKHLWRQPRRPIRIQQRFYSDPDKSAGCRERD
LSPRPELRKSRLSWPVSSCRRFDLENGLSCGRRALDPQSSPGLGRIMQAPVPHSQRRESF
LYRSDSDYELSPKAMSRNSSVASDLHGEDMIVTPFAQVLASLRTVRSNVAALARQQCLGA
AKQGPVGNPSSSNQLPPAEDTGQKLALETLDELDWCLDQLETLQTRHSVGEMASNKFKRI
LNRELTHLSETSRSGNQVSEYISRTFLDQQTEVELPKVTAEEAPQPMSRISGLHGLCHSA
SLSSATVPRFGVQTDQEEQLAKELEDTNKWGLDVFKVAELSGNRPLTAIIFSIFQERDLL
KTFQIPADTLATYLLMLEGHYHANVAYHNSLHAADVAQSTHVLLATPALEAVFTDLEILA
ALFASAIHDVDHPGVSNQFLINTNSELALMYNDASVLENHHLAVGFKLLQAENCDIFQNL
SAKQRLSLRRMVIDMVLATDMSKHMNLLADLKTMVETKKVTSLGVLLLDNYSDRIQVLQN
LVHCADLSNPTKPLPLYRQWTDRIMAEFFQQGDRERESGLDISPMCDKHTASVEKSQVGF
IDYIAHPLWETWADLVHPDAQDLLDTLEDNREWYQSKIPRSPSDLTNPERDGPDRFQFEL
TLEEAEEEDEEEEEEGEETALAKEALELPDTELLSPEAGPDPGDLPLDNQRT

BDBM285539

n/a

Name

BDBM285539

Synonyms:

3-(4-chloro-2-methyl-phenyl)-N-cyclopropyl-imidazo[1,2-b]pyridazine-2-carboxamide | US10077269, Example 12 | US10669279, Example 12 | US9598421, Example 12

Type

Small organic molecule

Emp. Form.

C17H15ClN4O

Mol. Mass.

326.78

SMILES

Cc1cc(Cl)ccc1-c1c(nc2cccnn12)C(=O)NC1CC1 |(2.81,-8.2,;4.3,-7.8,;4.7,-6.31,;6.19,-5.91,;6.58,-4.43,;7.27,-7,;6.88,-8.49,;5.39,-8.89,;4.99,-10.38,;5.89,-11.62,;4.99,-12.87,;3.52,-12.39,;2.19,-13.16,;.86,-12.39,;.86,-10.85,;2.19,-10.08,;3.52,-10.85,;7.44,-11.62,;8.21,-10.29,;8.21,-12.96,;9.75,-12.96,;11.08,-13.73,;11.08,-12.19,)|

Structure