| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Phosphodiesterase 4A (PDE4) |
|---|
| Ligand | BDBM285598 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Scintillation Proximity Assay (SPA) |
|---|
| IC50 | <0.669±n/a nM |
|---|
| Citation |  Chappie TA; Verhoest PR; Patel NC; Hayward MM; Helal CJ; Sciabola S; LaChapelle EA; Young JM Imidazopyridazine compounds US Patent US9598421 Publication Date 3/21/2017 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Phosphodiesterase 4A (PDE4) |
|---|
| Name: | Phosphodiesterase 4 and 5 (PDE4 and PDE5) |
|---|
| Synonyms: | DPDE2 | PDE46 | PDE4A | Phosphodiesterase 4A (PDE4) |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 98113.27 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P27815 |
|---|
| Residue: | 886 |
|---|
| Sequence: | MEPPTVPSERSLSLSLPGPREGQATLKPPPQHLWRQPRTPIRIQQRGYSDSAERAERERQ
PHRPIERADAMDTSDRPGLRTTRMSWPSSFHGTGTGSGGAGGGSSRRFEAENGPTPSPGR
SPLDSQASPGLVLHAGAATSQRRESFLYRSDSDYDMSPKTMSRNSSVTSEAHAEDLIVTP
FAQVLASLRSVRSNFSLLTNVPVPSNKRSPLGGPTPVCKATLSEETCQQLARETLEELDW
CLEQLETMQTYRSVSEMASHKFKRMLNRELTHLSEMSRSGNQVSEYISTTFLDKQNEVEI
PSPTMKEREKQQAPRPRPSQPPPPPVPHLQPMSQITGLKKLMHSNSLNNSNIPRFGVKTD
QEELLAQELENLNKWGLNIFCVSDYAGGRSLTCIMYMIFQERDLLKKFRIPVDTMVTYML
TLEDHYHADVAYHNSLHAADVLQSTHVLLATPALDAVFTDLEILAALFAAAIHDVDHPGV
SNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEDNCDIFQNLSKRQRQSLRKMVIDM
VLATDMSKHMTLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLRNMVHCADLSNPTKPLE
LYRQWTDRIMAEFFQQGDRERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWADL
VHPDAQEILDTLEDNRDWYYSAIRQSPSPPPEEESRGPGHPPLPDKFQFELTLEEEEEEE
ISMAQIPCTAQEALTAQGLSGVEEALDATIAWEASPAQESLEVMAQEASLEAELEAVYLT
QQAQSTGSAPVAPDEFSSREEFVVAVSHSSPSALALQSPLLPAWRTLSVSEHAPGLPGLP
STAAEVEAQREHQAAKRACSACAGTFGEDTSALPAPGGGGSGGDPT
|
|
|
|---|
| BDBM285598 |
|---|
| n/a |
|---|
| Name | BDBM285598 |
|---|
| Synonyms: | 3-(3-chloro-4-methylphenyl)-N-[(1R,2S)-2-fluorocyclopro-pyl]imidazo[1,2-b]pyridazine-2-carboxamide | US10077269, Example 71 | US9598421, Example 71 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C17H14ClFN4O |
|---|
| Mol. Mass. | 344.771 |
|---|
| SMILES | Cc1ccc(cc1Cl)-c1c(nc2cccnn12)C(=O)N[C@@H]1C[C@@H]1F |r| |
|---|
| Structure | 
|
|---|
Search and Browse
