| Reaction Details |
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 | Report a problem with these data |
| Target | cAMP-specific 3',5'-cyclic phosphodiesterase 4D |
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| Ligand | BDBM285634 |
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| Substrate/Competitor | n/a |
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| IC50 | 145±n/a nM |
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| Citation |  Chappie, TA; Verhoest, PR; Patel, NC; Hayward, MM; Helal, CJ; Sciabola, S; LaChapelle, EA; Young, JM Imidazopyridazine compounds US Patent US9598421 Publication Date 3/21/2017 |
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| More Info.: | Get all data from this article, Assay Method |
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| cAMP-specific 3',5'-cyclic phosphodiesterase 4D |
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| Name: | cAMP-specific 3',5'-cyclic phosphodiesterase 4D |
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| Synonyms: | 3',5'-cyclic phosphodiesterase | DPDE3 | PDE43 | PDE4D | PDE4D_HUMAN | Phosphodiesterase 4D |
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| Type: | Protein |
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| Mol. Mass.: | 91092.69 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q08499 |
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| Residue: | 809 |
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| Sequence: | MEAEGSSAPARAGSGEGSDSAGGATLKAPKHLWRHEQHHQYPLRQPQFRLLHPHHHLPPP
PPPSPQPQPQCPLQPPPPPPLPPPPPPPGAARGRYASSGATGRVRHRGYSDTERYLYCRA
MDRTSYAVETGHRPGLKKSRMSWPSSFQGLRRFDVDNGTSAGRSPLDPMTSPGSGLILQA
NFVHSQRRESFLYRSDSDYDLSPKSMSRNSSIASDIHGDDLIVTPFAQVLASLRTVRNNF
AALTNLQDRAPSKRSPMCNQPSINKATITEEAYQKLASETLEELDWCLDQLETLQTRHSV
SEMASNKFKRMLNRELTHLSEMSRSGNQVSEFISNTFLDKQHEVEIPSPTQKEKEKKKRP
MSQISGVKKLMHSSSLTNSSIPRFGVKTEQEDVLAKELEDVNKWGLHVFRIAELSGNRPL
TVIMHTIFQERDLLKTFKIPVDTLITYLMTLEDHYHADVAYHNNIHAADVVQSTHVLLST
PALEAVFTDLEILAAIFASAIHDVDHPGVSNQFLINTNSELALMYNDSSVLENHHLAVGF
KLLQEENCDIFQNLTKKQRQSLRKMVIDIVLATDMSKHMNLLADLKTMVETKKVTSSGVL
LLDNYSDRIQVLQNMVHCADLSNPTKPLQLYRQWTDRIMEEFFRQGDRERERGMEISPMC
DKHNASVEKSQVGFIDYIVHPLWETWADLVHPDAQDILDTLEDNREWYQSTIPQSPSPAP
DDPEEGRQGQTEKFQFELTLEEDGESDTEKDSGSQVEEDTSCSDSKTLCTQDSESTEIPL
DEQVEEEAVGEEEESQPEACVIDDRSPDT
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| BDBM285634 |
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| n/a |
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| Name | BDBM285634 |
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| Synonyms: | 3-(4-chloro-3,5-difluoro-phenyl)-N-cyclopropyl-imidazo[1,2-b]pyridazine-2-carboxamide | US10077269, Example 104 | US10669279, Example 104 | US9598421, Example 104 |
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| Type | Small organic molecule |
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| Emp. Form. | C16H11ClF2N4O |
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| Mol. Mass. | 348.735 |
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| SMILES | Fc1cc(cc(F)c1Cl)-c1c(nc2cccnn12)C(=O)NC1CC1 |
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| Structure | 
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