Reaction Details | |||
---|---|---|---|
Report a problem with these data | |||
Target | Casein kinase I isoform epsilon | ||
Ligand | BDBM302453 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | Kinase Assay | ||
IC50 | <10±n/a nM | ||
Citation | Velaparthi, U; Darne, CP; Liu, P; Wittman, MD; Pearce, BC; Araujo, EM; Dasgupta, B; Nair, JS; Janakiraman, SK; Rachamreddy, CR; Mettu, MR; Karuppiah, AM; Reddy, BS; Nagalakshmi, P; Bora, RO; Maheshwarappa, SH; Kumaravel, S; Mullick, D; Sistla, R Substituted 4,5,6,7-tetrahydropyrazolo[1,5-A]pyrazine derivatives as casein kinase 1 D/E inhibitors US Patent US9598423 Publication Date 3/21/2017 | ||
More Info.: | Get all data from this article, Assay Method | ||
Casein kinase I isoform epsilon | |||
Name: | Casein kinase I isoform epsilon | ||
Synonyms: | Axin-1/Casein kinase I epsilon | CKI-epsilon | CKIe | CSNK1E | Casein kinase 1 epsilon (CK1Æ) | Casein kinase I epsilon | Casein kinase I isoform epsilon (CK1 epsilon) | Casein kinase I isoform epsilon (CK1E) | Casein kinase I isoform epsilon (CK1epsilon) | KC1E_HUMAN | ||
Type: | Protein | ||
Mol. Mass.: | 47340.25 | ||
Organism: | Homo sapiens (Human) | ||
Description: | P49674 | ||
Residue: | 416 | ||
Sequence: |
| ||
BDBM302453 | |||
n/a | |||
Name | BDBM302453 | ||
Synonyms: | N5-(Adamantan-2-yl)-2- (3-fluorophenyl)-6,7- dihydropyrazolo[1,5-a] pyrazine-3,5(4H)- dicarboxamide | US9598423, Example 19 | ||
Type | Small organic molecule | ||
Emp. Form. | C24H28FN5O2 | ||
Mol. Mass. | 437.5098 | ||
SMILES | NC(=O)c1c2CN(CCn2nc1-c1cccc(F)c1)C(=O)NC1C2CC3CC(C2)CC1C3 |TLB:28:23:31:26.27.29,28:27:22.23.24:31,THB:21:22:31:26.27.29,26:25:22:28.27.29,26:27:22:24.25.31,(-2.46,1.95,;-1.37,3.04,;-1.77,4.52,;.12,2.64,;.59,1.17,;-.18,-.16,;.59,-1.49,;2.13,-1.49,;2.9,-.16,;2.13,1.17,;2.61,2.64,;1.36,3.54,;1.36,5.08,;.03,5.85,;.03,7.39,;1.36,8.16,;2.7,7.39,;4.03,8.16,;2.7,5.85,;-.18,-2.83,;-1.72,-2.83,;.59,-4.16,;-.18,-5.5,;-1.72,-5.5,;-2.49,-6.83,;-1.72,-8.16,;-3.26,-8.16,;-4.03,-6.83,;-3.26,-5.5,;-.74,-7.6,;.59,-6.83,;-.18,-8.16,)| | ||
Structure |