| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Casein kinase I isoform epsilon |
|---|
| Ligand | BDBM302457 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Kinase Assay |
|---|
| IC50 | <10±n/a nM |
|---|
| Citation |  Velaparthi, U; Darne, CP; Liu, P; Wittman, MD; Pearce, BC; Araujo, EM; Dasgupta, B; Nair, JS; Janakiraman, SK; Rachamreddy, CR; Mettu, MR; Karuppiah, AM; Reddy, BS; Nagalakshmi, P; Bora, RO; Maheshwarappa, SH; Kumaravel, S; Mullick, D; Sistla, R Substituted 4,5,6,7-tetrahydropyrazolo[1,5-A]pyrazine derivatives as casein kinase 1 D/E inhibitors US Patent US9598423 Publication Date 3/21/2017 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Casein kinase I isoform epsilon |
|---|
| Name: | Casein kinase I isoform epsilon |
|---|
| Synonyms: | Axin-1/Casein kinase I epsilon | CKI-epsilon | CKIe | CSNK1E | Casein kinase 1 epsilon (CK1Æ) | Casein kinase I epsilon | Casein kinase I isoform epsilon (CK1 epsilon) | Casein kinase I isoform epsilon (CK1E) | Casein kinase I isoform epsilon (CK1epsilon) | KC1E_HUMAN |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 47340.25 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P49674 |
|---|
| Residue: | 416 |
|---|
| Sequence: | MELRVGNKYRLGRKIGSGSFGDIYLGANIASGEEVAIKLECVKTKHPQLHIESKFYKMMQ
GGVGIPSIKWCGAEGDYNVMVMELLGPSLEDLFNFCSRKFSLKTVLLLADQMISRIEYIH
SKNFIHRDVKPDNFLMGLGKKGNLVYIIDFGLAKKYRDARTHQHIPYRENKNLTGTARYA
SINTHLGIEQSRRDDLESLGYVLMYFNLGSLPWQGLKAATKRQKYERISEKKMSTPIEVL
CKGYPSEFSTYLNFCRSLRFDDKPDYSYLRQLFRNLFHRQGFSYDYVFDWNMLKFGAARN
PEDVDRERREHEREERMGQLRGSATRALPPGPPTGATANRLRSAAEPVASTPASRIQPAG
NTSPRAISRVDRERKVSMRLHRGAPANVSSSDLTGRQEVSRIPASQTSVPFDHLGK
|
|
|
|---|
| BDBM302457 |
|---|
| n/a |
|---|
| Name | BDBM302457 |
|---|
| Synonyms: | 2-(3-Fluorophenyl)-N5- ((2R,5S)-octahydro-2,5- methanopentalen-6a-yl)- 6,7-dihydropyrazolo[1,5- a]pyrazine-3,5(4H)- dicarboxamide | US9598423, Example 23 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C23H26FN5O2 |
|---|
| Mol. Mass. | 423.4832 |
|---|
| SMILES | NC(=O)c1c2CN(CCn2nc1-c1cccc(F)c1)C(=O)NC12CC3CC1CC(C2)C3 |TLB:25:24:26.27:29,THB:25:26:30.24.23:29,27:28:23:26.25,27:26:23:30.28.29| |
|---|
| Structure | 
|
|---|
Search and Browse
