| Reaction Details |
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 | Report a problem with these data |
| Target | Nuclear receptor ROR-beta |
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| Ligand | BDBM302858 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Biological Assay |
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| Ki | >12500±n/a nM |
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| Citation |  Morphy, JR Compounds useful for inhibiting ROR-gamma-t US Patent US9598431 Publication Date 3/21/2017 |
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| More Info.: | Get all data from this article, Assay Method |
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| Nuclear receptor ROR-beta |
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| Name: | Nuclear receptor ROR-beta |
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| Synonyms: | NR1F2 | Nuclear receptor RZR-beta | Nuclear receptor subfamily 1 group F member 2 | RORB | RORB_HUMAN | RZRB | Retinoid-related orphan receptor-beta |
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| Type: | PROTEIN |
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| Mol. Mass.: | 53227.30 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_107979 |
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| Residue: | 470 |
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| Sequence: | MCENQLKTKADATAQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQNNASYSCPRQ
RNCLIDRTNRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLYAEVQKHQQRLQEQRQ
QQSGEAEALARVYSSSISNGLSNLNNETSGTYANGHVIDLPKSEGYYNVDSGQPSPDQSG
LDMTGIKQIKQEPIYDLTSVPNLFTYSSFNNGQLAPGITMTEIDRIAQNIIKSHLETCQY
TMEELHQLAWQTHTYEEIKAYQSKSREALWQQCAIQITHAIQYVVEFAKRITGFMELCQN
DQILLLKSGCLEVVLVRMCRAFNPLNNTVLFEGKYGGMQMFKALGSDDLVNEAFDFAKNL
CSLQLTEEEIALFSSAVLISPDRAWLIEPRKVQKLQEKIYFALQHVIQKNHLDDETLAKL
IAKIPTITAVCNLHGEKLQVFKQSHPEIVNTLFPPLYKELFNPDCATGCK
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| BDBM302858 |
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| n/a |
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| Name | BDBM302858 |
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| Synonyms: | N-{[5-(Ethylsulfonyl)pyridine-2-yl]methyl}-5′-methyl-1-{1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}-4′,5′-dihydrospiro[piperidine-4,7′thieno[2,3-C]pyran]-2′-carboxamide | US9598431, 1 |
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| Type | Small organic molecule |
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| Emp. Form. | C28H32F3N5O4S2 |
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| Mol. Mass. | 623.71 |
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| SMILES | CCS(=O)(=O)c1ccc(CNC(=O)c2cc3CC(C)OC4(CCN(CC4)C(C)c4cnc(nc4)C(F)(F)F)c3s2)nc1 |$;;;;;;;;;;HN;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;$| |
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| Structure | 
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