| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Nuclear receptor ROR-alpha |
|---|
| Ligand | BDBM302860 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Biological Assay |
|---|
| Ki | >20400±0 nM |
|---|
| Citation |  Morphy, JR Compounds useful for inhibiting ROR-gamma-t US Patent US9598431 Publication Date 3/21/2017 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Nuclear receptor ROR-alpha |
|---|
| Name: | Nuclear receptor ROR-alpha |
|---|
| Synonyms: | NR1F1 | Nuclear receptor RZR-alpha | Nuclear receptor subfamily 1 group F member 1 | RAR-related orphan receptor A | RORA | RORA_HUMAN | RZRA | Retinoid-related orphan receptor-alpha |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 58976.26 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | ChEMBL_101591 |
|---|
| Residue: | 523 |
|---|
| Sequence: | MESAPAAPDPAASEPGSSGADAAAGSRETPLNQESARKSEPPAPVRRQSYSSTSRGISVT
KKTHTSQIEIIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQSNATYSCPRQKNCLIDRT
SRNRCQHCRLQKCLAVGMSRDAVKFGRMSKKQRDSLYAEVQKHRMQQQQRDHQQQPGEAE
PLTPTYNISANGLTELHDDLSNYIDGHTPEGSKADSAVSSFYLDIQPSPDQSGLDINGIK
PEPICDYTPASGFFPYCSFTNGETSPTVSMAELEHLAQNISKSHLETCQYLREELQQITW
QTFLQEEIENYQNKQREVMWQLCAIKITEAIQYVVEFAKRIDGFMELCQNDQIVLLKAGS
LEVVFIRMCRAFDSQNNTVYFDGKYASPDVFKSLGCEDFISFVFEFGKSLCSMHLTEDEI
ALFSAFVLMSADRSWLQEKVKIEKLQQKIQLALQHVLQKNHREDGILTKLICKVSTLRAL
CGRHTEKLMAFKAIYPDIVRLHFPPLYKELFTSEFEPAMQIDG
|
|
|
|---|
| BDBM302860 |
|---|
| n/a |
|---|
| Name | BDBM302860 |
|---|
| Synonyms: | (2S)-1-(3-Thienyl)propan-2-ol | US9598431, 3 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C28H32F3N5O4S2 |
|---|
| Mol. Mass. | 623.71 |
|---|
| SMILES | CCS(=O)(=O)c1ccc(CNC(=O)c2cc3C[C@H](C)OC4(CCN(CC4)[C@H](C)c4cnc(nc4)C(F)(F)F)c3s2)nc1 |r| |
|---|
| Structure | 
|
|---|
Search and Browse
