Ki Summary BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
TargetTyrosine-protein kinase JAK1 [861-1152]
LigandBDBM174020
Substrate/Competitorn/a
Meas. Tech.JAK1 Kinase Assay
IC50 8.00±n/a nM
Citation Brasca, MGBindi, SCaldarelli, MNesi, MOrrenius, SCPanzeri, A Substituted pyrroles active as kinases inhibitors US Patent US9688661 Publication Date 6/27/2017
More Info.:Get all data from this article,  Assay Method
 
Tyrosine-protein kinase JAK1 [861-1152]
Name:Tyrosine-protein kinase JAK1 [861-1152]
Synonyms:JAK1 | JAK1A | JAK1B | JAK1_HUMAN | Tyrosine-protein kinase JAK1 (JAK1)
Type:Protein
Mol. Mass.:33439.94
Organism:Homo sapiens (Human)
Description:Human JAK1 variant (861-1152 aa)
Residue:292
Sequence:
PATEVDPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSLKPESGGNHIA
DLKKEIEILRNLYHENIVKYKGICTEDGGNGIKLIMEFLPSGSLKEYLPKNKNKINLKQQ
LKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVKDD
RDSPVFWYAPECLMQSKFYIASDVWSFGVTLHELLTYCDSDSSPMALFLKMIGPTHGQMT
VTRLVNTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRTSFQNLIEGFEAL
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM174020
n/a
NameBDBM174020
Synonyms:US9688661, 1-(5-Chloro-2-ethylphenyl)-4-(6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrrole-2-carboxamide (compd 241)
TypeSmall organic molecule
Emp. Form.C18H18ClN6O
Mol. Mass.369.828
SMILESCCc1ccc(Cl)cc1-n1cn(cc1C(N)=O)-c1ncnc2CCNc12
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: