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TargetTyrosine-protein kinase JAK1 [861-1152]
LigandBDBM50069316
Substrate/Competitorn/a
Meas. Tech.JAK1 Kinase Assay
IC50 4.00±n/a nM
Citation Brasca, MGBindi, SCaldarelli, MNesi, MOrrenius, SCPanzeri, A Substituted pyrroles active as kinases inhibitors US Patent US9688661 Publication Date 6/27/2017
More Info.:Get all data from this article,  Assay Method
 
Tyrosine-protein kinase JAK1 [861-1152]
Name:Tyrosine-protein kinase JAK1 [861-1152]
Synonyms:JAK1 | JAK1A | JAK1B | JAK1_HUMAN | Tyrosine-protein kinase JAK1 (JAK1)
Type:Protein
Mol. Mass.:33439.94
Organism:Homo sapiens (Human)
Description:Human JAK1 variant (861-1152 aa)
Residue:292
Sequence:
PATEVDPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSLKPESGGNHIA
DLKKEIEILRNLYHENIVKYKGICTEDGGNGIKLIMEFLPSGSLKEYLPKNKNKINLKQQ
LKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVKDD
RDSPVFWYAPECLMQSKFYIASDVWSFGVTLHELLTYCDSDSSPMALFLKMIGPTHGQMT
VTRLVNTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRTSFQNLIEGFEAL
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  Blast E-value cutoff:
BDBM50069316
n/a
NameBDBM50069316
Synonyms:CHEMBL3403549 | US9688661, 1-[2-Chloro-5-(trifluoromethyl)phenyl]-4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrrole-2-carboxamide (compd 244)
TypeSmall organic molecule
Emp. Form.C18H11ClF3N5O
Mol. Mass.405.761
SMILESNC(=O)c1cc(cn1-c1cc(ccc1Cl)C(F)(F)F)-c1ncnc2[nH]ccc12
Structure
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