| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Non-receptor tyrosine-protein kinase TYK2 [833-1187] |
|---|
| Ligand | BDBM50069316 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | TYK2 Kinase Assay |
|---|
| IC50 | 3.00±n/a nM |
|---|
| Citation |  Brasca, MG; Bindi, S; Caldarelli, M; Nesi, M; Orrenius, SC; Panzeri, A Substituted pyrroles active as kinases inhibitors US Patent US9688661 Publication Date 6/27/2017 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Non-receptor tyrosine-protein kinase TYK2 [833-1187] |
|---|
| Name: | Non-receptor tyrosine-protein kinase TYK2 [833-1187] |
|---|
| Synonyms: | Non-receptor tyrosine-protein kinase TYK2 (TYK2) | TYK2 | TYK2_HUMAN |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 40613.06 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Human TYK2 variant (833-1187 aa) |
|---|
| Residue: | 355 |
|---|
| Sequence: | LPEPSCPQLATLTSQCLTYEPTQRPSFRTILRDLTRLQPHNLADVLTVNPDSPASDPTVF
HKRYLKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKADCGPQHRSGWKQEIDILR
TLYHEHIIKYKGCCEDQGEKSLQLVMEYVPLGSLRDYLPRHSIGLAQLLLFAQQICEGMA
YLHAQHYIHRDLAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDSPVFWYAPEC
LKEYKFYYASDVWSFGVTLYELLTHCDSSQSPPTKFLELIGIAQGQMTVLRLTELLERGE
RLPRPDKCPCEVYHLMKNCWETEASFRPTFENLIPILKTVHEKYQGQAPSVFSVC
|
|
|
|---|
| BDBM50069316 |
|---|
| n/a |
|---|
| Name | BDBM50069316 |
|---|
| Synonyms: | CHEMBL3403549 | US9688661, 1-[2-Chloro-5-(trifluoromethyl)phenyl]-4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrrole-2-carboxamide (compd 244) |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C18H11ClF3N5O |
|---|
| Mol. Mass. | 405.761 |
|---|
| SMILES | NC(=O)c1cc(cn1-c1cc(ccc1Cl)C(F)(F)F)-c1ncnc2[nH]ccc12 |
|---|
| Structure | 
|
|---|
Search and Browse
