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TargetComplement factor D
LigandBDBM303024
Substrate/Competitorn/a
Meas. Tech.Factor D Assay
IC50<1000±n/a nM
Citation Gadhachanda, VRHashimoto, APais, GWang, QChen, DWang, XAgarwal, ADeshpande, MWiles, JAPhadke, AS Amino compounds for treatment of complement mediated disorders US Patent US9598446 Publication Date 3/21/2017
More Info.:Get all data from this article,  Assay Method
 
Complement factor D
Name:Complement factor D
Synonyms:Adipsin | C3 convertase activator | CFAD_HUMAN | CFD | DF | PFD | Properdin factor D
Type:Protein
Mol. Mass.:27039.19
Organism:Homo sapiens (Human)
Description:P00746
Residue:253
Sequence:
MHSWERLAVLVLLGAAACAAPPRGRILGGREAEAHARPYMASVQLNGAHLCGGVLVAEQW
VLSAAHCLEDAADGKVQVLLGAHSLSQPEPSKRLYDVLRAVPHPDSQPDTIDHDLLLLQL
SEKATLGPAVRPLPWQRVDRDVAPGTLCDVAGWGIVNHAGRRPDSLQHVLLPVLDRATCN
RRTHHDGAITERLMCAESNRRDSCKGDSGGPLVCGGVLEGVVTSGSRVCGNRKKPGIYTR
VASYAAWIDSVLA
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  Blast E-value cutoff:
BDBM303024
n/a
NameBDBM303024
Synonyms:(2S,4R)-1-(2-(3- acetyl-5-(pyrimidin-5- ylamino)-1H-indol-1- yl)acetyl)-N-(3-(2- chlorophenyl)-1,2,4- thiadiazol-5-yl)-4- fluoropyrrolidine-2- carboxamide | US10660876, Cmpd No. 29 | US9598446, Compound 29
TypeSmall organic molecule
Emp. Form.C29H24ClFN8O3S
Mol. Mass.619.069
SMILESCC(=O)c1cn(CC(=O)N2C[C@H](F)C[C@H]2C(=O)Nc2nc(ns2)-c2ccccc2Cl)c2ccc(Nc3cncnc3)cc12 |r,$;;;;;;;;;;;;;;;;;HN;;;;;;;;;;;;;;;;;;;;;;;;;$|
Structure
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