Reaction Details |
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Target | Cyclin-H/Cyclin-dependent kinase 7 |
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Ligand | BDBM8061 |
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Substrate/Competitor | Biotinylated Peptide Substrate |
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Meas. Tech. | CDK Inhibition Assay |
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pH | 7.2±n/a |
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Temperature | 303.15±n/a K |
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Ki | 70±10 nM |
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Citation | Wang, S; Wood, G; Meades, C; Griffiths, G; Midgley, C; McNae, I; McInnes, C; Anderson, S; Jackson, W; Mezna, M; Yuill, R; Walkinshaw, M; Fischer, PM Synthesis and biological activity of 2-anilino-4-(1H-pyrrol-3-yl) pyrimidine CDK inhibitors. Bioorg Med Chem Lett14:4237-40 (2004) [PubMed] Article |
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More Info.: | Get all data from this article, Inhibition_Run data, Solution Info, Assay Method |
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Cyclin-H/Cyclin-dependent kinase 7 |
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Name: | Cyclin-H/Cyclin-dependent kinase 7 |
Synonyms: | CDK-activating kinase assembly factor MAT1/Cyclin H/Cyclin-dependent kinase 7 | CDK7/Cyclin H | CDK7/H | Cyclin H/dependent kinase 7 | Cyclin-Dependent Kinase 7 (CDK7) | Cyclin-dependent kinase 7/ cyclin H | Cyclin-dependent kinase 7/cyclin H |
Type: | Protein Complex |
Mol. Mass.: | n/a |
Description: | n/a |
Components: | This complex has 2 components. |
Component 1 |
Name: | Cyclin-H |
Synonyms: | CCNH | CCNH_HUMAN | Cyclin H | MO15-associated protein | p34 | p37 |
Type: | Enzyme Subunit |
Mol. Mass.: | 37646.05 |
Organism: | Homo sapiens (Human) |
Description: | n/a |
Residue: | 323 |
Sequence: | MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYY
EKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNV
SSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPI
LENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKE
NRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDD
DYVSKKSKHEEEEWTDDDLVESL
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Component 2 |
Name: | Cyclin-dependent kinase 7 |
Synonyms: | 39 kDa protein kinase | CAK | CAK1 | CDK-activating kinase | CDK-activating kinase 1 (CAK) | CDK7 | CDK7_HUMAN | CDKN7 | Cell division protein kinase 7 | Cyclin-Dependent Kinase 7 (CDK7) | Cyclin-dependent kinase 7 (CDK7/cyclin H) | MO15 | P39 Mo15 | STK1 | TFIIH basal transcription factor complex kinase subunit |
Type: | Enzyme Subunit |
Mol. Mass.: | 39047.01 |
Organism: | Homo sapiens (Human) |
Description: | n/a |
Residue: | 346 |
Sequence: | MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTAL
REIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLM
TLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRA
PELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDM
CSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPG
PTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF
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BDBM8061 |
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Biotinylated Peptide Substrate |
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Name: | Biotinylated Peptide Substrate |
Synonyms: | n/a |
Type: | Peptide |
Mol. Mass.: | 10968.97 |
Organism: | n/a |
Description: | n/a |
Residue: | 86 |
Sequence: | ITINYLAHTYRSERPRTHRSERPRSERTYRSERPRTHRSERPRSERTYRSERPRTHRSER
PRSERTYRSERPRTHRSERPRSERNH
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